pH-Responsive Multicomponent Nanocomposite for Enhanced Reactive Oxygen Species Generation and Targeted Apoptosis-Induced Synergistic Cancer Treatment (Adv. Healthcare Mater. 27/2025)

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-10-21 DOI:10.1002/adhm.70263

Chang Hyeon Ha, Do Hyeon Kim, Gi Hun Seong

引用次数: 0

Abstract

Cancer-Targeted Drug Delivery System

The HA-CS@Pt-GOx can be easily introduced into cells via specific endocytosis through the CD44 receptor. Subsequently, it can effectively induce cell death by forming toxic reactive oxygen species and lipid peroxides using excess intracellular glucose and hydrogen peroxide. More details can be found in the Research Article by Gi Hun Seong and co-workers (DOI: 10.1002/adhm.202502370).

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ph响应多组分纳米复合材料增强活性氧生成和靶向细胞凋亡诱导的协同癌症治疗（Adv. Healthcare Mater. 27/2025）

HA-CS@Pt-GOx可以很容易地通过CD44受体通过特异性内吞作用引入细胞。随后，它利用过量的细胞内葡萄糖和过氧化氢形成有毒的活性氧和脂质过氧化物，从而有效地诱导细胞死亡。更多细节可以在Gi Hun Seong及其同事的研究文章中找到（DOI: 10.1002/adhm.202502370）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.