Biomaterials最新文献

Corrigendum to "Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity" [Biomaterials 314 (2025) 122908].

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 Epub Date: 2024-11-28 DOI: 10.1016/j.biomaterials.2024.122973

Sumanta Ghosh, Mengjia Zheng, Jiahui He, Yefeng Wu, Yaming Zhang, Weiping Wang, Jie Shen, Kelvin W K Yeung, Prasanna Neelakantan, Chenjie Xu, Wei Qiao

引用次数: 0

Corrigendum to "Poly(β-amino ester) polymer library with monomer variation for mRNA delivery" [Biomaterials 314 (2025) 122896]. 用于递送 mRNA 的具有单体变化的聚（β-氨基酯）聚合物库"[《生物材料》314 (2025) 122896]的更正。

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 Epub Date: 2024-11-22 DOI: 10.1016/j.biomaterials.2024.122966

Hong Lyun Kim, Gurusamy Saravanakumar, Seowon Lee, Subin Jang, Seonwoo Kang, Mihyeon Park, Sivasangu Sobha, So-Hee Park, Soo-Min Kim, Jung-Ah Lee, Eunkyung Shin, You-Jin Kim, Hye-Sook Jeong, Dokeun Kim, Won Jong Kim

引用次数: 0

Corrigendum to 'Enhancing CAR-T cell therapy against solid tumor by drug-free triboelectric immunotherapy' [Biomaterials 314 (2025) 122871]. 通过无药三电免疫疗法增强针对实体瘤的 CAR-T 细胞疗法"[《生物材料》314 (2025) 122871] 勘误。

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 Epub Date: 2024-10-31 DOI: 10.1016/j.biomaterials.2024.122927

Haimei Li, Zichen Wang, Yulin Hu, Guangqin He, Liang Huang, Yi Liu, Zhong Lin Wang, Peng Jiang

引用次数: 0

Corrigendum to "Dual-step irradiation strategy to sequentially destroy singlet oxygen-responsive polymeric micelles and boost photodynamic cancer therapy" [Biomater. 275 (2021) 120959]. 双步辐照策略连续破坏单线态氧响应性聚合物胶束并促进光动力癌症疗法》[Biomater. 275 (2021) 120959]的更正。

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 Epub Date: 2024-11-12 DOI: 10.1016/j.biomaterials.2024.122952

Kai Deng, Hui Yu, Jia-Mi Li, Kun-Heng Li, Hong-Yang Zhao, Min Ke, Shi-Wen Huang

引用次数: 0

Phototheranostics: An advanced approach for precise diagnosis and treatment of gynecological inflammation and tumors.

IF 12.8 1区医学

Biomaterials Pub Date : 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123012

Qihang Ding, Aoxue Guo, Shuai Zhang, Chuanqi Gu, Xinyu Wang, Xin Li, Meijia Gu, Jong Seung Kim

{"title":"Phototheranostics: An advanced approach for precise diagnosis and treatment of gynecological inflammation and tumors.","authors":"Qihang Ding, Aoxue Guo, Shuai Zhang, Chuanqi Gu, Xinyu Wang, Xin Li, Meijia Gu, Jong Seung Kim","doi":"10.1016/j.biomaterials.2024.123012","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123012","url":null,"abstract":"Gynecological inflammations have a significant impact on the daily lives of women. Meanwhile, cancers such as ovarian, cervical, and endometrial cancers pose severe threats to their physical and mental well-being. While current options such as conventional pharmacotherapy, surgical interventions, and recent advancements in immunotherapy and targeted therapy provide viable solutions, they possess limitations in effectively addressing the intricacies associated with gynecological diseases. These complexities include post-surgical complications, early cancer detection, and drug resistance. The management of these challenges, however, requires the implementation of innovative treatment modalities. Phototheranostics has emerged as a promising approach to effectively address these challenges. It not only treats inflammation and tumors efficiently but also aids in disease imaging and diagnosis. The distinguishing features of phototheranostics lie in their non-invasive nature, minimal risk of drug resistance, and precise targeting capabilities through the use of photosensitizers or photothermal agents. These distinctive features underscore its potential to revolutionize early diagnosis and treatment of gynecological conditions. This review aims to summarize the application of phototheranostics in managing gynecological inflammation and tumors while highlighting its significant potential for early disease detection and treatment.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123012"},"PeriodicalIF":12.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging nanomedicines for macrophage-mediated cancer therapy.

IF 12.8 1区医学

Biomaterials Pub Date : 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123028

Xueying Shi, Syed Faheem Askari Rizvi, Yinxian Yang, Gang Liu

{"title":"Emerging nanomedicines for macrophage-mediated cancer therapy.","authors":"Xueying Shi, Syed Faheem Askari Rizvi, Yinxian Yang, Gang Liu","doi":"10.1016/j.biomaterials.2024.123028","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123028","url":null,"abstract":"Tumor-associated macrophages (TAMs) contribute to tumor progression by promoting angiogenesis, remodeling the tumor extracellular matrix, inducing tumor invasion and metastasis, as well as immune evasion. Due to the high plasticity of TAMs, they can polarize into different phenotypes with distinct functions, which are primarily categorized as the pro-inflammatory, anti-tumor M1 type, and the anti-inflammatory, pro-tumor M2 type. Notably, anti-tumor macrophages not only directly phagocytize tumor cells, but also present tumor-specific antigens and activate adaptive immunity. Therefore, targeted regulation of TAMs to unleash their potential anti-tumor capabilities is crucial for improving the efficacy of cancer immunotherapy. Nanomedicine serves as a promising vehicle and can inherently interact with TAMs, hence, emerging as a new paradigm in cancer immunotherapy. Due to their controllable structures and properties, nanomedicines offer a plethora of advantages over conventional drugs, thus enhancing the balance between efficacy and toxicity. In this review, we provide an overview of the hallmarks of TAMs and discuss nanomedicines for targeting TAMs with a focus on inhibiting recruitment, depleting and reprogramming TAMs, enhancing phagocytosis, engineering macrophages, as well as targeting TAMs for tumor imaging. We also discuss the challenges and clinical potentials of nanomedicines for targeting TAMs, aiming to advance the exploitation of nanomedicine for cancer immunotherapy.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123028"},"PeriodicalIF":12.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage-hitchhiked, effervescence-induced nanoemulsions for enhanced oral chemotherapy and immunotherapy: Impact on absorption route.

IF 12.8 1区医学

Biomaterials Pub Date : 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123019

Nhien Nguyen, Tuyet-Mai Hoang, Tun-Yu Huang, Lam-Duc-Huy Nguyen, Hsiao-Huan Chang, Yen Chang, Mai Thanh Thi Nguyen, Kun-Ju Lin, Chun-Chieh Chen, Hsing-Wen Sung

{"title":"Macrophage-hitchhiked, effervescence-induced nanoemulsions for enhanced oral chemotherapy and immunotherapy: Impact on absorption route.","authors":"Nhien Nguyen, Tuyet-Mai Hoang, Tun-Yu Huang, Lam-Duc-Huy Nguyen, Hsiao-Huan Chang, Yen Chang, Mai Thanh Thi Nguyen, Kun-Ju Lin, Chun-Chieh Chen, Hsing-Wen Sung","doi":"10.1016/j.biomaterials.2024.123019","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123019","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer. Paclitaxel (PTX), typically administered intravenously (IV) as chemotherapy, shows promise for triggering immunogenic cell death (ICD) and may serve as a potential immunotherapy. This study introduces an oral PTX delivery method using an enteric-coated gelatin capsule containing capric acid oil and an effervescent agent, optionally with decylamine-conjugated β-glucans (DA-βGlus). Upon dissolving in the small intestine, the capsule undergoes an effervescence reaction that produces emulsified oil droplets (ODs) by bile salts, forming either Bared/ODs/PTX or DA-βGlus/ODs/PTX, with the latter featuring surface-attached DA-βGlus. The study evaluates the oral absorption, pharmacokinetics, and therapeutic efficacy of these formulations, comparing them to IV administration. IV PTX causes rapid spikes in plasma concentration, quick metabolism, and elimination, which can be unsafe. In contrast, the oral delivery system maintains consistent drug levels in the bloodstream for longer periods, improving overall effectiveness. Bared/ODs/PTX follows conventional fat absorption pathways, limiting tumor targeting. On the other hand, DA-βGlus/ODs/PTX uses DA-βGlus to enhance specificity for tumors through endogenous macrophage-mediated transport, effectively acting as \"cellular tumor-seeking vehicles\". This method reduces tumor stroma fibrosis, delivers PTX precisely, induces apoptosis, triggers PTX-induced ICD, and enhances cytotoxic T cell responses, augmenting targeted anti-PDAC strategies.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123019"},"PeriodicalIF":12.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amplifying Ca²⁺ overload by engineered biomaterials for synergistic cancer therapy.

IF 12.8 1区医学

Biomaterials Pub Date : 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123027

Jun-Long Liang, Yangyang Cao, Kaiwei Lv, Bing Xiao, Jihong Sun

{"title":"Amplifying Ca2+ overload by engineered biomaterials for synergistic cancer therapy.","authors":"Jun-Long Liang, Yangyang Cao, Kaiwei Lv, Bing Xiao, Jihong Sun","doi":"10.1016/j.biomaterials.2024.123027","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123027","url":null,"abstract":"Ca2+ overload is one of the most widely causes of inducing apoptosis, pyroptosis, immunogenic cell death, autophagy, paraptosis, necroptosis, and calcification of tumor cells, and has become the most valuable therapeutic strategy in the field of cancer treatment. Nevertheless, several challenges remain in translating Ca2+ overload-mediated therapeutic strategies into clinical applications, such as the precise control of Ca2+ dynamics, specificity of Ca2+ homeostasis dysregulation, as well as comprehensive mechanisms of Ca2+ regulation. Given this, we comprehensively reviewed the Ca2+-driven intracellular signaling pathways and the application of Ca2+-based biomaterials (such as CaCO3-, CaP-, CaO2-, CaSi-, CaF2-, and CaH2-) in mediating cancer diagnosis, treatment, and immunotherapy. Meanwhile, the latest researches on Ca2+ overload-mediated therapeutic strategies, as well as those combined with multiple-model therapies in mediating cancer immunotherapy are further highlighted. More importantly, the critical challenges and the future prospects of the Ca2+ overload-mediated therapeutic strategies are also discussed. By consolidating recent findings and identifying future research directions, this review aimed to advance the field of oncology therapy and contribute to the development of more effective and targeted treatment modalities.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123027"},"PeriodicalIF":12.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lighthouses illuminating tumor metastasis: The application of fluorescent probes in the localization and imaging metastatic lymph nodes across various tumors.

IF 12.8 1区医学

Biomaterials Pub Date : 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123020

Qi Dang, Linhao Zhang, Huipeng Ma, Xiaoshan Sun, Anguo Ren, Jiuyang Chen, Xiaohua Huang, Boyu Zhang, Wen Sun

{"title":"Lighthouses illuminating tumor metastasis: The application of fluorescent probes in the localization and imaging metastatic lymph nodes across various tumors.","authors":"Qi Dang, Linhao Zhang, Huipeng Ma, Xiaoshan Sun, Anguo Ren, Jiuyang Chen, Xiaohua Huang, Boyu Zhang, Wen Sun","doi":"10.1016/j.biomaterials.2024.123020","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123020","url":null,"abstract":"The significance of metastatic lymph nodes in tumor diagnosis and prognosis is self-evident. With the deepening of research on the lymphatic system and the advancement of imaging technology, an increasing number of near-infrared fluorescent probes targeting tumor metastatic lymph nodes have been developed. These probes can identify tumors while further detecting lymph nodes (LNs), showcasing great potential in image-guided surgery. In this review, we comprehensively outline the design strategies and applications of near-infrared fluorescent probes for cancers with a high propensity for lymph node metastasis during disease progression. Particular emphasis is placed on two targeting mechanisms: tumor-directed probes capable of identifying metastatic lymph nodes and lymph node-specific probes utilizing passive targeting of metastatic lymph nodes or active targeting of lymph nodes directly. Additionally, we discuss current issues and future prospects in this field, which will facilitate the development of new fluorescent probes and their further clinical translation.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123020"},"PeriodicalIF":12.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "PB@PDA@Ag nanosystem for synergistically eradicating MRSA and accelerating diabetic wound healing assisted with laser irradiation" [Biomaterials 243 (2020) 119936].

IF 12.8 1区医学

Biomaterials Pub Date : 2024-12-11 DOI: 10.1016/j.biomaterials.2024.122993

Chunyi Tong, Xianghua Zhong, Yuejun Yang, Xu Liu, Guowei Zhong, Chang Xiao, Bin Liu, Wei Wang, Xiaoping Yang

引用次数: 0