Biomaterials最新文献

A heterojunction-engineering nanodrug with tumor microenvironment responsiveness for tumor-specific cuproptosis and chemotherapy amplified sono-immunotherapy

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-02 DOI: 10.1016/j.biomaterials.2025.123319

Yang Wang , Tingting Yan , Jinming Cai , Hongjing Dou , Yu Zhu , Bijiang Geng , Dengyu Pan , Longxiang Shen

{"title":"A heterojunction-engineering nanodrug with tumor microenvironment responsiveness for tumor-specific cuproptosis and chemotherapy amplified sono-immunotherapy","authors":"Yang Wang , Tingting Yan , Jinming Cai , Hongjing Dou , Yu Zhu , Bijiang Geng , Dengyu Pan , Longxiang Shen","doi":"10.1016/j.biomaterials.2025.123319","DOIUrl":"10.1016/j.biomaterials.2025.123319","url":null,"abstract":"<div><div>Cuproptosis has recently identified as a unique copper-dependent cell death mechanism that may provide new opportunities for improving the therapeutic effect of tumor therapy through triggering efficient adaptive immune responses. However, the poor delivery efficiency and non-tumor-specific release of Cu ions would restrict the potential clinical applications of cuproptosis inducers. Herein, we report for the first time the development of hollow Cu<sub>2-x</sub>Se nanocubes as the tumor microenvironment (TME)-responsive drug delivery systems and cuproptosis inducers for tumor-specific chemotherapy and cuproptosis. The presence of Cu vacancy endows Cu<sub>2-x</sub>Se with excellent sonodynamic and chemodynamic activity. The hollow Cu<sub>2-x</sub>Se nanocubes with TME-responsive degradation behaviors are further utilized to load graphene quantum dot (GQD) nanodrugs to form GQD/Cu<sub>2-x</sub>Se heterojunctions for achieving tumor-specific chemotherapy. The heterojunction-fabrication GQD/Cu<sub>2-x</sub>Se exhibits amplified ROS generation capabilities and improved TME regulation ability owing to the optimized electron-hole separation kinetics. More importantly, the significant increase in ROS levels and efficient cuproptosis could reverse the immunosuppressive TME and induce immunogenic cell death that stimulates strong systemic immune responses to eliminate tumors. Collectively, this work presents an innovative strategy for the utilization of TME-responsive cuproptosis inducers for tumor-specific chemotherapy and cuproptosis augmented sono-immunotherapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123319"},"PeriodicalIF":12.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies to enhance the penetration of nanomedicine in solid tumors

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 DOI: 10.1016/j.biomaterials.2025.123315

Sen Liu , Zhendong Ren , Manqi Yan , Wei Ye , Yong Hu

{"title":"Strategies to enhance the penetration of nanomedicine in solid tumors","authors":"Sen Liu , Zhendong Ren , Manqi Yan , Wei Ye , Yong Hu","doi":"10.1016/j.biomaterials.2025.123315","DOIUrl":"10.1016/j.biomaterials.2025.123315","url":null,"abstract":"<div><div>Nanomedicine was previously regarded as a promising solution in the battle against cancer. Over the past few decades, extensive research has been conducted to exploit nanomedicine for overcoming tumors. Unfortunately, despite these efforts, nanomedicine has not yet demonstrated its ability to cure tumors, and the research on nanomedicine has reached a bottleneck. For a significant period of time, drug delivery strategies have primarily focused on targeting nanomedicine delivery to tumors while neglecting its redistribution within solid tumors. The uneven distribution of nanomedicine within solid tumors results in limited therapeutic effects on most tumor cells and significantly hampers the efficiency of drug delivery and treatment outcomes. Therefore, this review discusses the challenges faced by nanomedicine in penetrating solid tumors and provides an overview of current nanotechnology strategies (alleviating penetration resistance, size regulation, tumor cell transport, and nanomotors) that facilitate enhanced penetration of nanomedicine into solid tumors. Additionally, we discussed the potential role of nanobionics in promoting effective penetration of nanomedicine.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123315"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A transcatheter mitral valve clip with a central filler for mitral valve regurgitation

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 DOI: 10.1016/j.biomaterials.2025.123317

Tingchao Zhang , Weiwei Zhang , Xianzhang Zhen , Rifang Luo , Li Yang , Xingdong Zhang , Yunbing Wang

{"title":"A transcatheter mitral valve clip with a central filler for mitral valve regurgitation","authors":"Tingchao Zhang , Weiwei Zhang , Xianzhang Zhen , Rifang Luo , Li Yang , Xingdong Zhang , Yunbing Wang","doi":"10.1016/j.biomaterials.2025.123317","DOIUrl":"10.1016/j.biomaterials.2025.123317","url":null,"abstract":"<div><div>Despite the advantages of transcatheter edge-to-edge repair (TEER) devices for treating mitral regurgitation, challenges such as difficulties in leaflet grasping and clip dislodgement remain in clinical practice. In this study, we present the first detailed disclosure of a novel transcatheter mitral valve clip, the DragonFly, highlighting its material composition, design features, and associated benefits. The valve clip is constructed of nickel-titanium alloy, stainless steel, cobalt-chromium alloy, and polyethylene terephthalate, incorporating adjustable arms, grippers, and a unique central filler. The central filler, made of nitinol, offers remarkable compressibility and shape recovery. The whole valve clip can endure over 400 million fatigue cycles and ensure a robust grasp on valve leaflets at varying angles. The clip presents sufficient grasping force to prevent valve dislodgement, and the adjustable design accommodates various patient anatomies. Comprehensive biocompatibility assessments confirmed adherence to ISO 10993 standards through in vitro and in vivo experiments, including large-animal studies. The results demonstrated that the valve clip successfully creates a stable double-orifice structure without negatively impacting cardiac hemodynamics and has good biocompatibility. Overall, the DragonFly valve clip constitutes a technological advancement in the field of minimally invasive interventions for mitral valve disease, offering more treatment options for high-risk patients.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123317"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-resolved T1 and T2 contrast for enhanced accuracy in MRI tumor detection

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 DOI: 10.1016/j.biomaterials.2025.123313

Zhongzhong Lu , Jincong Yan , Jianxian Zeng , Ruihao Zhang , Mingsheng Xu , Jihuan Liu , Lina Sun , Guangyue Zu , Xiaomin Chen , Ye Zhang , Renjun Pei , Yi Cao

{"title":"Time-resolved T1 and T2 contrast for enhanced accuracy in MRI tumor detection","authors":"Zhongzhong Lu , Jincong Yan , Jianxian Zeng , Ruihao Zhang , Mingsheng Xu , Jihuan Liu , Lina Sun , Guangyue Zu , Xiaomin Chen , Ye Zhang , Renjun Pei , Yi Cao","doi":"10.1016/j.biomaterials.2025.123313","DOIUrl":"10.1016/j.biomaterials.2025.123313","url":null,"abstract":"<div><div>Stimuli-responsive contrast agents (CAs) have shown great promise in enhancing magnetic resonance imaging (MRI) for more accurate tumor diagnosis. However, current CAs still face challenges in achieving high accuracy due to their low specificity and contrast signals being confounded by potential endogenous MRI artifacts. Herein, an extremely small iron oxide nanoparticle (ESIONP)-based smart responsive MRI contrast agent (LESPH) is proposed, which is meticulously designed with sequential dual biochemical stimuli-initiated, time-resolved T<sub>1</sub> and T<sub>2</sub> contrast presentation, ensuring high tumor specificity while minimizing interference from endogenous artifacts. LESPH is constructed using emulsion solvent evaporation by assembling poly(2-(hexamethyleneimino) ethyl methacrylate) terminally conjugated with a disulfide bond-linked catechol group (DSPH)-modified ESIONPs, with lauryl betaine serving as a surfactant. When LESPH undergoes sequential responses to the weak acidity and high-concentration glutathione (GSH) in the tumor microenvironment, it experiences an extremely rapid transition from sparse ESIONP assemblies to dispersed ESIONPs, followed by a slower transition to closely aggregated ones, concomitantly providing distinguishable brightening and darkening contrast enhancement at the tumor location on different time scales. By virtue of its sequential dual responsiveness and time-resolved distinguishable contrast enhancements, LESPH successfully detects tumors with extremely high accuracy, providing a novel paradigm for the precise medical diagnosis of cancer.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123313"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clearance of senescent vascular smooth muscle cells retards aging-related restenosis following bioresorbable scaffolds implantation

IF 12.8 1区医学

Biomaterials Pub Date : 2025-03-31 DOI: 10.1016/j.biomaterials.2025.123312

Yang Wang , Hang Zou , Zhufeng Dong , Wen Shi , Junyang Huang , Miaolong Yang , Xiaoqing Xiang , Li Xiaotong , Liu Zhifeng , Guixue Wang , Yazhou Wang , Tieying Yin

{"title":"Clearance of senescent vascular smooth muscle cells retards aging-related restenosis following bioresorbable scaffolds implantation","authors":"Yang Wang , Hang Zou , Zhufeng Dong , Wen Shi , Junyang Huang , Miaolong Yang , Xiaoqing Xiang , Li Xiaotong , Liu Zhifeng , Guixue Wang , Yazhou Wang , Tieying Yin","doi":"10.1016/j.biomaterials.2025.123312","DOIUrl":"10.1016/j.biomaterials.2025.123312","url":null,"abstract":"<div><div>In contrast to bioinert metal stents, the degradation of bioresorbable scaffolds (BRS) induces complex mechanical changes and accumulation of degradation products, potentially leading to adverse events following implantation into stenotic arteries. Atherosclerosis (AS) is a typical age-related disease, plaque formation and changes in vascular mechanical properties can significantly affect the process of restenosis and vascular repair after BRS implantation. The aging of vascular smooth muscle cells (VSMCs) is earlier than that of endothelial cells (ECs) and plays a decisive role in the mechanical properties of blood vessels. This study investigated the impact of senescent VSMCs (s-VSMCs) on the effectiveness of 3-D printed poly-<span><em>l</em></span>-lactide BRS implanted in the aged abdominal aortas of Sprague-Dawley rats over a 6-month period. Synthetic phenotype switch of s-VSMCs contribute to aging-related in-stent restenosis (ISR) and hinder neointima recovery, by reducing positive remodeling and impeding the neointima recovery of ECs. Further analysis indicated that the regulation of ECs was influenced by mechanoresponsive miRNAs and increased stiffness induced by s-VSMCs. To effectively eliminate s-VSMCs and accelerate vascular repair, two types of senolytic-coated BRS were developed and tested with ABT-263 and young plasma-derived exosomes. These results highlight the critical role of s-VSMCs in increasing aging-related ISR and delaying intima recovery following BRS implantation. The senolytic coatings, with their ability to clear senescent cells, promoted vascular repair. This study offers valuable insights for potential mechanisms responsible for the elevated ISR risks associated with BRS in aged aortas and the development of advanced BRS coatings.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123312"},"PeriodicalIF":12.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A remotely controlled nanotherapeutic with immunomodulatory property for MRSA-induced bone infection

IF 12.8 1区医学

Biomaterials Pub Date : 2025-03-29 DOI: 10.1016/j.biomaterials.2025.123298

Zhe Zhao , Yufei Zhang , Jie Li , Siyuan Huang , Guosheng Xing , Kai Zhang , Xinlong Ma , Xinge Zhang , Yingze Zhang

{"title":"A remotely controlled nanotherapeutic with immunomodulatory property for MRSA-induced bone infection","authors":"Zhe Zhao , Yufei Zhang , Jie Li , Siyuan Huang , Guosheng Xing , Kai Zhang , Xinlong Ma , Xinge Zhang , Yingze Zhang","doi":"10.1016/j.biomaterials.2025.123298","DOIUrl":"10.1016/j.biomaterials.2025.123298","url":null,"abstract":"<div><div>Osteomyelitis is a deep bone tissue infection caused by pathogenic microorganisms, with the primary pathogen being methicillin-resistant <em>Staphylococcus aureus</em> (MRSA). Due to the tendency of the infection site to form biofilms that shield drugs and immune cells to kill bacteria, combined with the severe local inflammatory response causing bone tissue destruction, the treatment of osteomyelitis poses a significant challenge. Herein, we developed a remotely controlled nanotherapeutic (TLBA) with immunomodulatory to treat MRSA-induced osteomyelitis. TLBA, combined with baicalin and gold nanorods, is positively charged to actively target and penetrate biofilms. Near-infrared light (808 nm) triggers spatiotemporal, controllable drug release, while bacteria are eliminated through synergistic interaction of non-antibiotic drugs and photothermal therapy, enhancing bactericidal efficiency and minimizing drug resistance. TLBA eliminated nearly 100 % of planktonic bacteria and dispersed 90 % of biofilms under NIR light stimulation. In MRSA-induced osteomyelitis rat models, laser irradiation raised the infection site temperature to 50 °C, effectively eradicating bacteria, promoting M2 macrophage transformation, inhibiting bone inflammation, curbing bone destruction, and fostering bone tissue repair. In summary, TLBA proposes a more comprehensive treatment strategy for the two characteristic pathological changes of bacterial infection and bone tissue damage in osteomyelitis.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123298"},"PeriodicalIF":12.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A functional cardiac patch with “gas and ion” dual-effect intervention for reconstructing blood microcirculation in myocardial infarction repair

IF 12.8 1区医学

Biomaterials Pub Date : 2025-03-29 DOI: 10.1016/j.biomaterials.2025.123300

Chaoran Zhao , Junjie Liu , Ye Tian , Zhentao Li , Jiang Zhao , Xianglong Xing , Xiaozhong Qiu , Leyu Wang

{"title":"A functional cardiac patch with “gas and ion” dual-effect intervention for reconstructing blood microcirculation in myocardial infarction repair","authors":"Chaoran Zhao , Junjie Liu , Ye Tian , Zhentao Li , Jiang Zhao , Xianglong Xing , Xiaozhong Qiu , Leyu Wang","doi":"10.1016/j.biomaterials.2025.123300","DOIUrl":"10.1016/j.biomaterials.2025.123300","url":null,"abstract":"<div><div>Postinfarction revascularization is critical for repairing the infarcted myocardium and for stopping disease progression. Considering the limitations of surgical intervention, engineered cardiac patches (ECPs) are more effective in establishing rich blood supply networks. For efficacy, ECPs should promote the formation of more mature blood vessels to improve microcirculatory dysfunction and mitigate hypoxia-induced apoptosis. Developing collateral circulation between infarcted myocardium and ECPs for restoring blood perfusion remains a challenge. Here, an ion-conductive composite ECPs (GMA@OSM) with powerful angiogenesis-promoting ability was constructed. Based on dual-effect intervention of oxygen and strontium, the developed ECPs can promote the formation of high-density circulating microvascular network at the infarcted myocardium. In addition, the GMA@OSM possesses effective reactive oxygen species-scavenging capacity and can facilitate electrophysiological repair of myocardium with ionic conductivity. <em>In vitro</em> and <em>in vivo</em> studies indicate that the multifunctional GMA@OSM ECPs form well-developed collateral circulation with infarcted myocardium to protect cardiomyocytes and improve cardiac function. Overall, this study highlights the potential of a multifunctional platform for developing collateral circulation, which can lead to an effective therapeutic strategy for repairing myocardial infarction.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123300"},"PeriodicalIF":12.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modification of MSCs with aHSCs-targeting peptide pPB for enhanced therapeutic efficacy in liver fibrosis

IF 12.8 1区医学

Biomaterials Pub Date : 2025-03-28 DOI: 10.1016/j.biomaterials.2025.123295

Mengqin Yuan , Zhengrong Yin , Zheng Wang , Zhiyu Xiong , Ping Chen , Lichao Yao , Pingji Liu , Muhua Sun , Kan Shu , Lanjuan Li , Yingan Jiang

{"title":"Modification of MSCs with aHSCs-targeting peptide pPB for enhanced therapeutic efficacy in liver fibrosis","authors":"Mengqin Yuan , Zhengrong Yin , Zheng Wang , Zhiyu Xiong , Ping Chen , Lichao Yao , Pingji Liu , Muhua Sun , Kan Shu , Lanjuan Li , Yingan Jiang","doi":"10.1016/j.biomaterials.2025.123295","DOIUrl":"10.1016/j.biomaterials.2025.123295","url":null,"abstract":"<div><div>Mesenchymal stem cells (MSCs) hold significant therapeutic potential for liver fibrosis but face translational challenges due to suboptimal homing efficiency and poor retention at injury sites. Activated hepatic stellate cells (aHSCs), the primary drivers of fibrogenesis, overexpress platelet-derived growth factor receptor-beta (PDGFRB), a validated therapeutic target in liver fibrosis. Here, we engineered pPB peptide-functionalized MSCs (pPB-MSCs) via hydrophobic insertion of DMPE-PEG-pPB (DPP) into the MSC membrane, creating a targeted “MSC-pPB-aHSC” delivery system. Our findings demonstrated that pPB modification preserved MSC viability, differentiation potential, and paracrine functions. pPB-MSCs exhibited higher binding affinity to TGF-β1-activated HSCs <em>in vitro</em> and greater hepatic accumulation in TAA-induced fibrotic mice, as quantified by <em>in vivo</em> imaging. Moreover, pPB-MSCs attenuated collagen deposition, suppressed α-SMA<sup>+</sup> HSCs, and restored serum ALT/AST levels to near-normal ranges. Mechanistically, pPB-MSCs promoted hepatocyte regeneration via HGF upregulation, inhibited epithelial-mesenchymal transition through TGF-β/Smad pathway suppression, and polarized macrophages toward an M2 phenotype, reducing pro-inflammatory IL-6/TNF-α while elevating anti-inflammatory IL-10. Overall, our study raised a non-genetic MSC surface engineering strategy that synergizes PDGFRB-targeted homing with multifactorial tissue repair, addressing critical barriers in cell therapy for liver fibrosis. By achieving enhanced spatial delivery without compromising MSC functionality, our approach provides a clinically translatable platform for enhancing regenerative medicine outcomes.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123295"},"PeriodicalIF":12.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel laser-textured grooves extended to the sidewall edges of CoCr surfaces for rapid and selective endothelialization following coronary artery stenting

IF 12.8 1区医学

Biomaterials Pub Date : 2025-03-27 DOI: 10.1016/j.biomaterials.2025.123299

Mohamed S. Ibrahim , Hassan Beheshti Seresht , Chang Hun Kum , Jae Hwa Cho , Gyuhyun Jin , Sang Hyun An , Sangho Ye , Seungil Kim , William R. Wagner , Youngjae Chun

{"title":"Novel laser-textured grooves extended to the sidewall edges of CoCr surfaces for rapid and selective endothelialization following coronary artery stenting","authors":"Mohamed S. Ibrahim , Hassan Beheshti Seresht , Chang Hun Kum , Jae Hwa Cho , Gyuhyun Jin , Sang Hyun An , Sangho Ye , Seungil Kim , William R. Wagner , Youngjae Chun","doi":"10.1016/j.biomaterials.2025.123299","DOIUrl":"10.1016/j.biomaterials.2025.123299","url":null,"abstract":"<div><div>The long-term performance of coronary stents is often compromised by delayed endothelialization and late thrombosis, particularly in drug-eluting stents (DES) that impair vascular healing. To address these challenges, we report a novel micro-hierarchical surface modification that integrates sidewall edge structuring into grid patterns on cobalt-chromium (CoCr) stents, enhancing endothelial cell (EC) interactions without compromising mechanical integrity. Laser fabrication was used to create microgrooves (5–30 μm) with extended sidewall edges, designed to promote rapid EC adhesion and proliferation. Comprehensive in vitro evaluations, including EC viability, adhesion, and platelet aggregation assays, demonstrated that stents with grid pattern and sidewall edge structuring on an already fabricated stent enhanced EC viability approximately six-fold compared to the non-patterned controls, reaching 2276 ± 220 cells/ml by day three of culture. The sidewall edges provided possible promising stable anchoring sites and gateway channels, improving EC attachment and selective alignment, while also substantially reducing platelet deposition in grooved regions. To ensure these surface modifications did not affect mechanical performance, comprehensive three-point bending and radial compression tests were conducted. No significant differences were observed compared to coronary stents, confirming that the micro-hierarchical texture with sidewall edges maintains essential mechanical properties. Together, these findings highlight the potential of sidewall edge-integrated grid patterns to accelerate endothelialization and reduce thrombogenic risks, offering a promising strategy for improving the design and long-term performance of next-generation coronary stents.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123299"},"PeriodicalIF":12.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An “all-in-one” therapeutic platform for programmed antibiosis, immunoregulation and neuroangiogenesis to accelerate diabetic wound healing

IF 12.8 1区医学

Biomaterials Pub Date : 2025-03-26 DOI: 10.1016/j.biomaterials.2025.123293

Yang Xue , Lan Zhang , Jun Chen , Dayan Ma , Yingang Zhang , Yong Han

{"title":"An “all-in-one” therapeutic platform for programmed antibiosis, immunoregulation and neuroangiogenesis to accelerate diabetic wound healing","authors":"Yang Xue , Lan Zhang , Jun Chen , Dayan Ma , Yingang Zhang , Yong Han","doi":"10.1016/j.biomaterials.2025.123293","DOIUrl":"10.1016/j.biomaterials.2025.123293","url":null,"abstract":"<div><div>Pathological microenvironment of diabetes induces a high risk of bacterial invasion, aggressive inflammatory response, and hindered neuroangiogenesis, leading to retarded ulcer healing. To address this, an “all-in-one” therapeutic platform, named MZZ, was constructed by loading maltodextrin onto a MOF-on-MOF structure (with ZIF-67 as the core and ZIF-8 as the shell) through a hybrid process of solvent treatment and electrostatic adsorption. Maltodextrin acts as a target to bind surrounding bacteria, and ZIF-8 as well as ZIF-67 responsively release Zn and Co ions, which not only kill most bacteria, but also improve the phagocytosis and xenophagy of M1 macrophages by up-regulating the expression levels of ATG5, Bcl1 and FLT4, helping the residual bacterial clearance. In inflammatory stage, MZZ scavenges extracellular and intracellular ROS by valence transition between Co<sup>2+</sup> and Co<sup>3+</sup>, and promote M1 macrophages to transform into M2 phenotype. In tissue reconstruction stage, the synergistic effect of Zn and Co ions as well as cytokines secreted by macrophages up-regulates cell vitality and biofunctions of endotheliocytes, neurocytes and fibroblasts. The programmed effects of MZZ on antibiosis, anti-inflammatory and neuroangiogenesis to accelerate wound repair are further confirmed in an infected diabetic model, and this “all-in-one” platform shows great clinical application potential.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"321 ","pages":"Article 123293"},"PeriodicalIF":12.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0