Biomaterials最新文献

{"title":"Stretchable semiconducting polymer aerogel transistors for high-performance biosensors and artificial synapses","authors":"Xiao Yang,&nbsp;Xu Chen,&nbsp;Puzhong Gu,&nbsp;Zhenyu Hu,&nbsp;Xiaoyu Zhang,&nbsp;Zejun Sun,&nbsp;Linlin Lu,&nbsp;Guoqing Zu,&nbsp;Jia Huang","doi":"10.1016/j.biomaterials.2025.123416","DOIUrl":"10.1016/j.biomaterials.2025.123416","url":null,"abstract":"<div><div>Stretchable organic electrochemical transistors (OECTs) are attractive for high-performance flexible electronics. Poly(3-hexylthiophene) (P3HT) and poly[2,5-(2-octyldodecyl)-3,6-diketopyrrolopyrrole-alt-5,5-(2,5-di(thien-2-yl)thieno [3,2-b]thiophene)] (DPPDTT) are commonly used for OECTs because of their excellent semiconducting properties. However, it is challenging to achieve stretchable and high-performance OECTs based on hydrophobic P3HT and DPPDTT because of their limited ion penetration. Here, unprecedented stretchable high-performance OECTs based on P3HT and DPPDTT aerogels with crimpled porous structures are developed. They are achieved by a pre-stretching strategy combined with sol-gel and template methods. The porous structures of the aerogels with high porosities facilitate ion penetration and transport, leading to the enhanced transconductance of the aerogel-based OECTs compared with those of the dense counterparts. The crimpled porous structures endow the aerogels and OECTs with good stretchability and stretching stability. The stretchable OECT-based biosensors can detect trace amounts of ascorbic acid in complex samples such as sweat, saliva, serum, and fruit juice in real time. Besides, the OECTs can be applied as stretchable artificial synapses for neuromorphic simulation. This work provides a powerful strategy toward stretchable high-performance transistors and flexible electronics.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123416"},"PeriodicalIF":12.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROS-catalytic self-amplifying benzothiophenazine-based photosensitive conjugates for photodynamic-immuno therapy","authors":"Zongwen Tan ,&nbsp;LeiLei Zhang ,&nbsp;Wei Dai ,&nbsp;Weirui Zhu ,&nbsp;Xiaoying Wang ,&nbsp;Tao Zhang","doi":"10.1016/j.biomaterials.2025.123413","DOIUrl":"10.1016/j.biomaterials.2025.123413","url":null,"abstract":"<div><div>Activatable photosensitizer (aPS)-mediated photodynamic therapy (PDT) holds great potential towards precision cancer treatment, but which generally suffers from low therapeutic outcomes due to the low activation efficiency of aPS and the low phototherapeutic effect of single PDT. In this study, we present a newly aPS designing strategy based on benzothiophenazine (BP) for fabrication of the robust small-molecule photosensitizer conjugates (SMPCs). Specifically, after systematically studying the photosensitizing mechanism of BP, a fully caged pro-photosensitizing platform (BP–Cl) was established, based on which we can introduced various amine molecules to create a series of reactive oxygen species (ROS)-catalytic self-amplifying SMPCs. As a proof of concept, we synthesized a SMPC (BP-Mel) by employing the chemotherapeutic melphalan to BP-Cl. Upon triggered by endogenous ROS, BP-Mel can achieve self-amplified activation under infrared illumination to efficiently produce the active BP for type I PDT, and along with the release of melphalan to induce immunogenic cell death in breast cancer cells. BP-Mel was encapsulated with resiquimod (R848) to form the nanoagonist (BMR), where BP-Mel induces localized tumor damage and immunogenic cell death and the TLR7/8 agonist R848 potently stimulates dendritic cell maturation and enhances tumor-specific T cell responses. BMR-mediated combination therapy induces powerful tumor suppression and immunotherapeutic cascade in EMT6-tumor-bearing mice. This study presents a scalable strategy for the customization of activatable photosensitive conjugates, exemplifying precise and efficient PDT.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123413"},"PeriodicalIF":12.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local delivery of siRNA using lipid-based nanocarriers with ROS-scavenging ability for accelerated chronic wound healing in diabetes","authors":"Yuanfeng Li ,&nbsp;Kaiyi Du ,&nbsp;Danfeng Peng ,&nbsp;Xuanlong Zhang ,&nbsp;Yinzi Piao ,&nbsp;Mengna Peng ,&nbsp;Wei He ,&nbsp;Yumeng Wang ,&nbsp;Haoyue Wu ,&nbsp;Yong Liu ,&nbsp;Jian Xiao ,&nbsp;Linqi Shi ,&nbsp;Dongdong Li","doi":"10.1016/j.biomaterials.2025.123411","DOIUrl":"10.1016/j.biomaterials.2025.123411","url":null,"abstract":"<div><div>Diabetic wound healing poses a significant clinical challenge with limited therapeutic efficacy due to uncontrolled reactive oxygen species (ROS), inflammatory responses, and extracellular matrix (ECM) degradation caused by abnormal macrophage activity in the wound microenvironment. To address these concerns, we propose a novel formulation that combines Tempo-conjugated lipid with the commercially cationic lipid DOTAP to expedite diabetic wound healing through targeted siRNA delivery (cL<em>p</em>T@siRNA) and restoration of the wound microenvironment. The developed cL<em>p</em>T@siRNA nanocomplexes effectively scavenge excessive ROS levels, facilitate polarization of proinflammatory M1 macrophages towards an anti-inflammatory M2 phenotype, and suppress MMP9 gene expression in macrophages. In the ICR mouse model of diabetic wounds, cL<em>p</em>T@siRNA nanocomplexes significantly accelerate wound healing, promoting neovascularization and collagen deposition. Overall, the cL<em>p</em>T@siRNA nanocomplexes based on antioxidant and cationic lipids provide a promising strategy for delivering siRNA in diabetic wound treatment and hold great potential for clinical translation.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123411"},"PeriodicalIF":12.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DLL4/VEGF bispecific molecularly imprinted nanomissile for robust tumor therapy","authors":"Fang Jin ,&nbsp;Peixin Guan ,&nbsp;Lingrui Huang ,&nbsp;Anqi Zhang ,&nbsp;Song Gao ,&nbsp;Lisheng Wang ,&nbsp;Zhen Liu","doi":"10.1016/j.biomaterials.2025.123412","DOIUrl":"10.1016/j.biomaterials.2025.123412","url":null,"abstract":"<div><div>Tumor-induced angiogenesis plays a pivotal role in the progression and expansion of solid tumors, making anti-angiogenic therapies a promising strategy in cancer treatment. However, compensatory angiogenesis, which can drive drug resistance and tumor recurrence, poses significant challenges in anti-angiogenic therapy. Therefore, improved anti-tumor angiogenesis therapy has become a critical necessity. Herein, we present a bispecific molecularly imprinted nanomissile (bsMINM) engineered to simultaneously target and inhibit both vascular endothelial growth factor (VEGF) and Delta-like 4 (DLL4). By blocking these two pivotal signals in tumor angiogenesis, bsMINM offers a potent “one-stone-for-two-birds” strategy that markedly enhances anti-tumor angiogenesis. The bsMINM features tailor-made binding sites for the N-epitopes of both VEGF and DLL4. This design allows bsMINM to persist at tumor sites effectively and diminish the negative feedback loop between VEGF and DLL4. The bsMINM inhibits VEGF-VEGFR signaling pathway in vascular endothelial cells and DLL4-Notch signaling pathway in both vascular endothelial cells and tumor cells, resulting in significant anti-tumor angiogenesis and growth inhibition. In the MCF-7 xenograft model, bsMINM exhibited a notable efficacy in restraining tumor progression while concurrently diminishing the self-renewal potential of cancer cells. This study pioneers the construction of the first bsMINM with inherent, enhanced anti-angiogenic effects achieved through dual blockades. The platform's bispecific recognition capability opens a new avenue for tumor treatment and shows significant promise in addressing issues caused by signaling pathway compensation.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123412"},"PeriodicalIF":12.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GSH-activable and cytolytic iPep-coupled immune nanoagonist for cancer synergetic therapy","authors":"Shuangshuang Ji ,&nbsp;Xiangxiang Xu ,&nbsp;Ang Li ,&nbsp;Hanjie Liu ,&nbsp;Jiang Zhu ,&nbsp;Hao Fei","doi":"10.1016/j.biomaterials.2025.123402","DOIUrl":"10.1016/j.biomaterials.2025.123402","url":null,"abstract":"<div><div>Integrating an oncotic immunogenic cell death (ICD) inducer with TLR agonists to facilitate chemo-immunotherapy presents a promising avenue for addressing cancer treatment. While each agent shown remarkable potential in eliciting immune responses individually, the synergistic capabilities of oncotic chemotherapeutics in combination with TLR agonists remain an uncharted area of research. Herein, to prevent the occurrence of off-target systemic inflammatory side effects associated with the TLR7/8 agonist, the reactive amino group of Resiquimod (R848) was covalently linked to human serum albumin (HSA) via a glutathione (GSH)-activatable linker, thereby establishing a series of R848-HSA conjugates. Specifically, RS-HSA (with an R848: HSA ratio of 1.6:1, n/n) was assembled with an oncotic membrane-active peptide (iPep) to form iP-RS NPs, which exhibited reduced toxicity and synergistic effects in modulating the tumor immunosuppressive microenvironment, disrupting the surrounding desmoplastic stroma, and enhancing anti-tumor immunity. The iP-RS NPs demonstrated satisfactory chemo-immune effects, achieving complete tumor regression in orthotopic 4T1 breast tumor mice and subcutaneous Panc02 pancreatic tumor mice. Furthermore, iP-RS NPs achieved successful treatment in three out of five mice harboring a clinically relevant and challenging orthotopic model of fLuc-KPC pancreatic ductal adenocarcinoma (PDAC), leading to a significant prolongation of their survival. In stark contrast, the first-line treatment regimen of Gemcitabine + Nab-paclitaxel offered only a marginal survival extension of less than a week when compared to the PBS control group. Our findings underscore the promising prospects of combining oncotic therapeutics with TLR7/8 agonists, with a rational design aimed at minimizing the toxicity of the TLR agonist while achieving superior synergistic therapeutic efficacy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123402"},"PeriodicalIF":12.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative DNA tetrahedron inspired by ancient mortise-and-tenon technique offers new immunotherapy strategy for metastatic breast cancer","authors":"Nan Zhang ,&nbsp;Lu Qian ,&nbsp;Chang Xu ,&nbsp;Fangfang Duan ,&nbsp;Yuxuan Ma ,&nbsp;Li Zhou ,&nbsp;Yuting Zhang ,&nbsp;Yi Ma ,&nbsp;Qiao Lin ,&nbsp;Kai Lu","doi":"10.1016/j.biomaterials.2025.123390","DOIUrl":"10.1016/j.biomaterials.2025.123390","url":null,"abstract":"<div><div>Framework nucleic acids effectively meet the demands for precise size control and accurate targeting in the design of drug delivery systems, while developing a controllable drug delivery system with low immunogenicity and high efficiency for delivering nucleic acid drugs to the tumor immune microenvironment (TIME) remains significant challenge. Inspired by ancient Chinese <em>mortise and tenon</em> joint structures, this study develops an intelligent self-assembling DNA tetrahedron (TDN@siCSF-1R), which consists of a gapped DNA tetrahedron (TDN) and a therapeutic siRNA against Colony-Stimulating Factor-1 Receptor (siCSF-1R) that non-covalently bind with TDN via its gap, aiming to target tumor-associated macrophages (TAMs) and inhibit the CSF-1R pathway. Additionally, a CD206 mRNA-responsive sequence is introduced into the gapped TDN, triggering the site-specific release of siCSF-1R in M2-like TAMs, thereby achieving the precise targeting of CSF-1R in M2-like TAMs and reducing off-target effect. The <em>mortise-and-tenon</em>-like TDN@siCSF-1R synchronously combines the self-assembly flexibility and structural stability, significantly inhibiting 4T1 tumor growth, lung metastasis, and tumor recurrence after resection in vivo. Furthermore, it repolarizes M2-like TAMs and activates infiltrating T cells in TIME, thereby reshaping the immunosuppressive microenvironment, and offering a promising strategy for the clinical application of cancer immunotherapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123390"},"PeriodicalIF":12.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'A simple soft lithographic route to fabrication of poly(ethylene glycol) microstructures for protein and cell patterning' [Biomaterials Volume 25 Issue 3, (2004) Pages 557-563].","authors":"Kahp Y Suh, Jiehyun Seong, Ali Khademhosseini, Paul E Laibinis, Robert Langer","doi":"10.1016/j.biomaterials.2025.123362","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123362","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"123362"},"PeriodicalIF":12.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significantly enhanced capture efficiency of cell-imprinted material for circulating tumor cells via a flexible and ultra-strong double-armed phenylboronic acid design","authors":"Wenjing Sun ,&nbsp;Xinmiao Zhao ,&nbsp;Xinjia Zhao ,&nbsp;Lingkai Meng ,&nbsp;Mingliang Tang ,&nbsp;Jiaqi Li ,&nbsp;Yongxin Chang ,&nbsp;Yuting Xiong ,&nbsp;Hao Wang ,&nbsp;Jinghua Chen ,&nbsp;Guangyan Qing","doi":"10.1016/j.biomaterials.2025.123397","DOIUrl":"10.1016/j.biomaterials.2025.123397","url":null,"abstract":"<div><div>Circulating tumor cells (CTC) have been incontrovertibly regarded as a critically essential detection tool within the realm of cancer combat, being decidedly preferred by oncology clinicians and serving as the preponderant primary targets for single-cell analysis. However, several challenges hinder the effective capture of CTC from blood, including their rarity, heterogeneity across cancer types, the complexity of the blood environment, and potential damage to cell viability. Here we design a flexible double-armed phenylboric acid (DPBA) that targets double-branched sialylated glycans (SGs) on the surface of liver CTC. The binding affinity of DPBA (200 nM) is 33 times greater than that of typical phenylboric acid, as confirmed by glycoproteomics analysis demonstrating a strong prevalence for SGs. By copolymerization of DPBA with polyethylene glycol dimethacrylate (PEGDMA), using SMMC-7721 cells as templates, we developed a cell-imprinted hydrogel featuring compact polymeric networks interconnected by both chemical crosslinking and hydrogen bonding. This hydrogel exhibits an ultra-low swelling capacity of 5 %, effectively preserving the nano- and micro-morphologies of cell imprinting. It also demonstrates low protein adhesion, appropriate elasticity and reversibility, as well as satisfactory blood and cell compatibility. The high affinity for double-branched SGs and clear cell imprinting endow the material with precise capture efficiency for CTC, enabling accurate discrimination between liver cancer patients and healthy individuals, with an excellent area under the curve (AUC) of 0.99 and a high classification accuracy of 96 %. Importantly, the captured CTC could be released alive for genomics analysis. The material costs just 1.98 dollars per sample, which is only 1/200th of the typical medical price. This study highlights the significant potential of flexible double-armed molecular design in the development of CTC capture materials, which will promote downstream single-cell multi-proteomics analysis and facilitate early cancer diagnostics.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123397"},"PeriodicalIF":12.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Bioprinting 3D microfibrous scaffolds for engineering cardiac tissues and heart-on-a-chip' [Biomaterials Volume 110, (2016) Pages 45-59].","authors":"Yu Shrike Zhang, Andrea Arneri, Simone Bersini, Su Ryon Shin, Kai Zhu, Zahra Goli-Malekabadi, Julio Aleman, Cristina Colosi, Fabio Busignani, Valeria Dell'Erba, Colin Bishop, Thomas Shupe, Danilo Demarchi, Matteo Moretti, Marco Rasponi, Mehmet Remzi Dokmeci, Anthony Atala, Ali Khademhosseini","doi":"10.1016/j.biomaterials.2025.123363","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123363","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"123363"},"PeriodicalIF":12.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Direct 3D bioprinting of perfusable vascular constructs using a blend bioink' [Biomaterials Volume 106, (2016) Pages 58-68].","authors":"Weitao Jia, P Selcan Gungor-Ozkerim, Yu Shrike Zhang, Kan Yue, Kai Zhu, Wanjun Liu, Qingment Pi, Batzaya Byambaa, Mehmet Remzi Dokmeci, Su Ryon Shin, Ali Khademhosseini","doi":"10.1016/j.biomaterials.2025.123364","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123364","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"123364"},"PeriodicalIF":12.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}