Biomaterials最新文献_第10页

Advanced nano delivery system for stem cell therapy for Alzheimer's disease 干细胞治疗阿尔茨海默病的先进纳米输送系统。

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-30 DOI: 10.1016/j.biomaterials.2024.122852

Yilong Pan , Long Li , Ning Cao , Jun Liao , Huiyue Chen , Meng Zhang

{"title":"Advanced nano delivery system for stem cell therapy for Alzheimer's disease","authors":"Yilong Pan , Long Li , Ning Cao , Jun Liao , Huiyue Chen , Meng Zhang","doi":"10.1016/j.biomaterials.2024.122852","DOIUrl":"10.1016/j.biomaterials.2024.122852","url":null,"abstract":"<div><div>Alzheimer's Disease (AD) represents one of the most significant neurodegenerative challenges of our time, with its increasing prevalence and the lack of curative treatments underscoring an urgent need for innovative therapeutic strategies. Stem cells (SCs) therapy emerges as a promising frontier, offering potential mechanisms for neuroregeneration, neuroprotection, and disease modification in AD. This article provides a comprehensive overview of the current landscape and future directions of stem cell therapy in AD treatment, addressing key aspects such as stem cell migration, differentiation, paracrine effects, and mitochondrial translocation. Despite the promising therapeutic mechanisms of SCs, translating these findings into clinical applications faces substantial hurdles, including production scalability, quality control, ethical concerns, immunogenicity, and regulatory challenges. Furthermore, we delve into emerging trends in stem cell modification and application, highlighting the roles of genetic engineering, biomaterials, and advanced delivery systems. Potential solutions to overcome translational barriers are discussed, emphasizing the importance of interdisciplinary collaboration, regulatory harmonization, and adaptive clinical trial designs. The article concludes with reflections on the future of stem cell therapy in AD, balancing optimism with a pragmatic recognition of the challenges ahead. As we navigate these complexities, the ultimate goal remains to translate stem cell research into safe, effective, and accessible treatments for AD, heralding a new era in the fight against this devastating disease.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"314 ","pages":"Article 122852"},"PeriodicalIF":12.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-organic framework-edaravone nanoparticles for radiotherapy-induced brain injury treatment 用于治疗放疗引起的脑损伤的金属有机框架-卡拉酮纳米粒子

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-30 DOI: 10.1016/j.biomaterials.2024.122868

Xuejiao Li , Shiyuan Hua , Danni Zhong , Min Zhou , Zhongxiang Ding

{"title":"Metal-organic framework-edaravone nanoparticles for radiotherapy-induced brain injury treatment","authors":"Xuejiao Li , Shiyuan Hua , Danni Zhong , Min Zhou , Zhongxiang Ding","doi":"10.1016/j.biomaterials.2024.122868","DOIUrl":"10.1016/j.biomaterials.2024.122868","url":null,"abstract":"<div><div>Cranial radiotherapy may cause damage to normal brain tissues and induce cognitive dysfunction, so developing an effective strategy to prevent radiotherapy-induced brain injury is essential. Metal-organic frameworks (MOFs) can be used as vectors for the delivery of neuroprotective drugs due to their high drug loading capacity and low toxicity. In this study, we synthesized MIL-53(Cr) nanoparticles, which were used to deliver edaravone, and modified the surface of the nanoparticles with polyethylene glycol and Angiopep-2 (EDA@MIL-53(Cr)–P/A) to improve their oral bioavailability and ability to cross the blood–brain barrier (BBB). We confirmed that MIL-53(Cr)–P/A nanoparticles could achieve the sustained release of edaravone and enhance its ability to cross the BBB. The results of <em>in vitro</em> experiments showed that EDA@MIL-53(Cr)–P/A could exert radioprotective effects on HT22 and BV2 cells. We also demonstrated that EDA@MIL-53(Cr)–P/A could alleviate brain injury and cognitive dysfunction in mice receiving whole-brain irradiation. Mechanistically, EDA@MIL-53(Cr)–P/A alleviated irradiation-induced brain damage by inhibiting oxidative stress, DNA damage, apoptosis and inflammatory reactions. This study provides a new strategy for the protection against radiotherapy-induced brain injury.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"314 ","pages":"Article 122868"},"PeriodicalIF":12.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomaterials for reliable wearable health monitoring: Applications in skin and eye integration 用于可靠的可穿戴健康监测的生物材料：皮肤和眼部一体化应用。

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-29 DOI: 10.1016/j.biomaterials.2024.122862

Seokkyoon Hong , Tianhao Yu , Ziheng Wang , Chi Hwan Lee

{"title":"Biomaterials for reliable wearable health monitoring: Applications in skin and eye integration","authors":"Seokkyoon Hong , Tianhao Yu , Ziheng Wang , Chi Hwan Lee","doi":"10.1016/j.biomaterials.2024.122862","DOIUrl":"10.1016/j.biomaterials.2024.122862","url":null,"abstract":"<div><div>Recent advancements in biomaterials have significantly impacted wearable health monitoring, creating opportunities for personalized and non-invasive health assessments. These developments address the growing demand for customized healthcare solutions. Durability is a critical factor for biomaterials in wearable applications, as they must withstand diverse wearing conditions effectively. Therefore, there is a heightened focus on developing biomaterials that maintain robust and stable functionalities, essential for advancing wearable sensing technologies. This review examines the biomaterials used in wearable sensors, specifically those interfaced with human skin and eyes, highlighting essential strategies for achieving long-lasting and stable performance. We specifically discuss three main categories of biomaterials—hydrogels, fibers, and hybrid materials—each offering distinct properties ideal for use in durable wearable health monitoring systems. Moreover, we delve into the latest advancements in biomaterial-based sensors, which hold the potential to facilitate early disease detection, preventative interventions, and tailored healthcare approaches. We also address ongoing challenges and suggest future directions for research on material-based wearable sensors to encourage continuous innovation in this dynamic field.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"314 ","pages":"Article 122862"},"PeriodicalIF":12.8,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ‘Engineered cell-laden human protein-based elastomer’ [34(2013), 5496–5505] 基于人体蛋白质的工程细胞弹性体"[34(2013), 5496-5505]的更正。

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-29 DOI: 10.1016/j.biomaterials.2024.122850

Nasim Annabi , Suzanne M. Mithieux , Pinar Zorlutuna , Gulden Camci-Unal , Anthony S. Weiss , Ali Khademhosseini

引用次数: 0

Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants 巨噬细胞微RNA-146a是生物材料植入物异物反应的核心调节因子。

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-29 DOI: 10.1016/j.biomaterials.2024.122855

Manisha Mahanty , Bidisha Dutta , Wenquan Ou , Xiaoping Zhu , Jonathan S. Bromberg , Xiaoming He , Shaik O. Rahaman

{"title":"Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants","authors":"Manisha Mahanty , Bidisha Dutta , Wenquan Ou , Xiaoping Zhu , Jonathan S. Bromberg , Xiaoming He , Shaik O. Rahaman","doi":"10.1016/j.biomaterials.2024.122855","DOIUrl":"10.1016/j.biomaterials.2024.122855","url":null,"abstract":"<div><div>Host recognition and immune-mediated foreign body response (FBR) to biomaterials can adversely affect the functionality of implanted materials. FBR presents a complex bioengineering and medical challenge due to the lack of current treatments, making the detailed exploration of its molecular mechanisms crucial for developing new and effective therapies. To identify key molecular targets underlying the generation of FBR, here we perform analysis of microRNAs (miR) and mRNAs responses to implanted biomaterials. We found that (a) miR-146a levels inversely affect macrophage accumulation, foreign body giant cell (FBGC) formation, and fibrosis in a murine implant model; (b) macrophage-derived miR-146a is a crucial regulator of the FBR and FBGC formation, as confirmed by global and cell-specific knockout of miR-146a; (c) miR-146a modulates genes related to inflammation, fibrosis, and mechanosensing; (d) miR-146a modulates tissue stiffness near the implant during FBR as assessed by atomic force microscopy; and (e) miR-146a is linked to F-actin production and cellular traction force induction as determined by traction force microscopy, which are vital for FBGC formation. These novel findings suggest that targeting macrophage miR-146a could be a selective strategy to inhibit FBR, potentially improving the biocompatibility of biomaterials.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"314 ","pages":"Article 122855"},"PeriodicalIF":12.8,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering hirudin encapsulation in pH-responsive antioxidant nanoparticles for therapeutic efficacy in ischemic stroke model mice 将水蛭素封装在 pH 值响应型抗氧化剂纳米颗粒中，对缺血性中风模型小鼠产生疗效。

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-28 DOI: 10.1016/j.biomaterials.2024.122860

Ting Mei , Peiwen Zhang , Yifan Hu , Liman Xiao , Junling Hou , Yukio Nagasaki

{"title":"Engineering hirudin encapsulation in pH-responsive antioxidant nanoparticles for therapeutic efficacy in ischemic stroke model mice","authors":"Ting Mei , Peiwen Zhang , Yifan Hu , Liman Xiao , Junling Hou , Yukio Nagasaki","doi":"10.1016/j.biomaterials.2024.122860","DOIUrl":"10.1016/j.biomaterials.2024.122860","url":null,"abstract":"<div><div>This study introduces a novel pH-sensitive, hirudin-loaded antioxidant nanoparticle (HD@iNano<sup>AOX</sup>) aimed at addressing the challenges of hirudin's short half-life and hemorrhagic transformation. HD@iNano<sup>AOX</sup> was engineered to safeguard and prolong hirudin's bioactivity by encapsulating it within antioxidative nanoparticles, facilitating its gradual release in acidic environments. The efficacy of this approach was validated through both <em>ex vivo</em> and <em>in vivo</em> experiments. <em>Ex vivo</em> thrombolytic assays demonstrated that HD@iNano<sup>AOX</sup> maintained effective clot lysis activity under acidic conditions. <em>In vivo</em> assessments revealed that HD@iNano<sup>AOX</sup> significantly prolonged hirudin's half-life and reduced cerebral infarct volume in a mouse model of middle cerebral artery occlusion (MCAO). Furthermore, HD@iNano<sup>AOX</sup> treatment mitigated cerebral oxidative stress, suppressed hemorrhagic transformation, and prevented blood-brain barrier (BBB) disruption. These findings suggest that the combined thrombolytic and antioxidative properties of HD@iNano<sup>AOX</sup> offer a promising therapeutic approach for ischemic stroke. Nonetheless, further research is warranted to optimize the formulation and assess its safety and efficacy in clinical settings.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"314 ","pages":"Article 122860"},"PeriodicalIF":12.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precise modulation of cell activity using sono-responsive nano-transducers 利用声波响应式纳米换能器精确调节细胞活性

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-28 DOI: 10.1016/j.biomaterials.2024.122857

Xuandi Hou, Langzhou Liu, Lei Sun

引用次数: 0

Synthetic nanomaterials for spleen-specific mRNA delivery 用于脾脏特异性 mRNA 递送的合成纳米材料。

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-28 DOI: 10.1016/j.biomaterials.2024.122859

Shihong Nie , Beiqi Yang , Ruiying Ma , Lili Zha , Yuyang Qin , Liyuan Ou , Xiaoyuan Chen , Ling Li

引用次数: 0

Engineered 3D human neurovascular model of Alzheimer's disease to study vascular dysfunction 设计阿尔茨海默病三维人体神经血管模型，研究血管功能障碍。

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-28 DOI: 10.1016/j.biomaterials.2024.122864

Georgios Pavlou , Sarah Spitz , Francesca Michela Pramotton , Alice Tsai , Brent M. Li , Xun Wang , Olivia M. Barr , Eunkyung Clare Ko , Shun Zhang , Savannah J. Ashley , Anna Maaser-Hecker , Se Hoon Choi , Mehdi Jorfi , Rudolph E. Tanzi , Roger D. Kamm

{"title":"Engineered 3D human neurovascular model of Alzheimer's disease to study vascular dysfunction","authors":"Georgios Pavlou , Sarah Spitz , Francesca Michela Pramotton , Alice Tsai , Brent M. Li , Xun Wang , Olivia M. Barr , Eunkyung Clare Ko , Shun Zhang , Savannah J. Ashley , Anna Maaser-Hecker , Se Hoon Choi , Mehdi Jorfi , Rudolph E. Tanzi , Roger D. Kamm","doi":"10.1016/j.biomaterials.2024.122864","DOIUrl":"10.1016/j.biomaterials.2024.122864","url":null,"abstract":"<div><div>The blood–brain barrier (BBB) serves as a selective filter that prevents harmful substances from entering the healthy brain. Dysfunction of this barrier is implicated in several neurological diseases. In the context of Alzheimer's disease (AD), BBB breakdown plays a significant role in both the initiation and progression of the disease. This study introduces a three-dimensional (3D) self-assembled <em>in vitro</em> model of the human neurovascular unit to recapitulate some of the complex interactions between the BBB and AD pathologies. It incorporates primary human brain endothelial cells, pericytes and astrocytes, and stem cell-derived neurons and astrocytes harboring Familial AD (FAD) mutations. Over an extended co-culture period, the model demonstrates increased BBB permeability, dysregulation of key endothelial and pericyte markers, and morphological alterations mirroring AD pathologies. The model enables visualization of amyloid-beta (Aβ) accumulation in both neuronal and vascular compartments. This model may serve as a versatile tool for neuroscience research and drug development to provide insights into the dynamic relationship between vascular dysfunction and AD pathogenesis.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"314 ","pages":"Article 122864"},"PeriodicalIF":12.8,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment 通过口服充电纳米微粒补充剂维持肌蛋白和氧化还原平衡，可有效治疗肌肉疏松症。

IF 12.8 1区医学

Biomaterials Pub Date : 2024-09-27 DOI: 10.1016/j.biomaterials.2024.122863

Yang Yu , Xuehan Jiang , Tianhao Yu , Fangman Chen , Runnian Huang , Zhe Xun , Xiaoxun Wang , Xu Liu , Xiaochun Xie , Chen Sun , Yingxi Xu , Xiyan Liu , Huayi Sun , Xiaoyue Yuan , Chunhua Ma , Yibai Li , Xiaoyu Song , Difei Wang , Dan Shao , Xuetao Shi , Liu Cao

{"title":"Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment","authors":"Yang Yu , Xuehan Jiang , Tianhao Yu , Fangman Chen , Runnian Huang , Zhe Xun , Xiaoxun Wang , Xu Liu , Xiaochun Xie , Chen Sun , Yingxi Xu , Xiyan Liu , Huayi Sun , Xiaoyue Yuan , Chunhua Ma , Yibai Li , Xiaoyu Song , Difei Wang , Dan Shao , Xuetao Shi , Liu Cao","doi":"10.1016/j.biomaterials.2024.122863","DOIUrl":"10.1016/j.biomaterials.2024.122863","url":null,"abstract":"<div><div>Sarcopenia is a progressive skeletal muscle disorder characterized by the accelerated loss of muscle mass and function, with no promising pharmacotherapies. Understanding the imbalance of myoprotein homeostasis within myotubes, which causes sarcopenia, may facilitate the development of novel treatments for clinical use. In this study, we found a strong correlation between low serum selenium levels and muscle function in elderly patients with sarcopenia. We hypothesized that supplementation with selenium might be beneficial for the management of sarcopenia. To verify this hypothesis, we developed diselenide-bridged mesoporous silica nanoparticles (Se–Se-MSNs) with ROS-responsive degradation and release to supplement selenium. Se–Se-MSNs outperformed free selenocysteine in alleviating sarcopenia in both dexamethasone (Dex)- and denervation-induced mouse models. Subsequently, Se–Se-MSNs were loaded with leucine (Leu@Se–Se-MSNs), another nutritional supplement used in sarcopenia management. Oral administration of Leu@Se–Se-MSNs restored myoprotein homeostasis by enhancing mTOR/S6K signaling and inactivating Akt/FoxO3a/MuRF1 signaling, thus exerting optimal therapeutic effects against sarcopenia and exhibiting a more favorable <em>in vivo</em> safety profile. This study provides a proof of concept for treating sarcopenia by maintaining myoprotein and redox homeostasis simultaneously and offers valuable insights into the development of multifunctional nanoparticle-based supplements for sarcopenia management.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"314 ","pages":"Article 122863"},"PeriodicalIF":12.8,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0