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Biodegradable stimulating electrodes for resident neural stem cell activation in vivo 用于激活体内驻留神经干细胞的可生物降解刺激电极。
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-09 DOI: 10.1016/j.biomaterials.2024.122957
Tianhao Chen , Kylie Sin Ki Lau , Aryan Singh , Yi Xin Zhang , Sara Mohseni Taromsari , Meysam Salari , Hani E. Naguib , Cindi M. Morshead
{"title":"Biodegradable stimulating electrodes for resident neural stem cell activation in vivo","authors":"Tianhao Chen ,&nbsp;Kylie Sin Ki Lau ,&nbsp;Aryan Singh ,&nbsp;Yi Xin Zhang ,&nbsp;Sara Mohseni Taromsari ,&nbsp;Meysam Salari ,&nbsp;Hani E. Naguib ,&nbsp;Cindi M. Morshead","doi":"10.1016/j.biomaterials.2024.122957","DOIUrl":"10.1016/j.biomaterials.2024.122957","url":null,"abstract":"<div><div>Brain stimulation has been recognized as a clinically effective strategy for treating neurological disorders. Endogenous brain neural precursor cells (NPCs) have been shown to be electrosensitive cells that respond to electrical stimulation by expanding in number, undergoing directed cathodal migration, and differentiating into neural phenotypes <em>in vivo</em>, supporting the application of electrical stimulation to promote neural repair. In this study, we present the design of a flexible and biodegradable brain stimulation electrode for temporally regulated neuromodulation of NPCs. Leveraging the cathodally skewed electrochemical window of molybdenum and the volumetric charge transfer properties of conductive polymer, we engineered the electrodes with high charge injection capacity for the delivery of biphasic monopolar stimulation. We demonstrate that the electrodes are biocompatible and can deliver an electric field sufficient for NPC activation for 7 days post implantation before undergoing resorption in physiological conditions, thereby eliminating the need for surgical extraction. The biodegradable electrode demonstrated its potential to be used for NPC-based neural repair strategies.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122957"},"PeriodicalIF":12.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory T cells engineered with polyphenol-functionalized immunosuppressant nanocomplexes for rebuilding periodontal hard tissue under inflammation-challenged microenvironment 利用多酚功能化免疫抑制剂纳米复合物设计的调节性 T 细胞,在炎症挑战的微环境下重建牙周硬组织。
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-09 DOI: 10.1016/j.biomaterials.2024.122961
Bo Zhang , Guidong Gong , Yunxiang He , Jialing Liu , Bo Wang , Yifei Li , Jie Fang , Zhihe Zhao , Junling Guo
{"title":"Regulatory T cells engineered with polyphenol-functionalized immunosuppressant nanocomplexes for rebuilding periodontal hard tissue under inflammation-challenged microenvironment","authors":"Bo Zhang ,&nbsp;Guidong Gong ,&nbsp;Yunxiang He ,&nbsp;Jialing Liu ,&nbsp;Bo Wang ,&nbsp;Yifei Li ,&nbsp;Jie Fang ,&nbsp;Zhihe Zhao ,&nbsp;Junling Guo","doi":"10.1016/j.biomaterials.2024.122961","DOIUrl":"10.1016/j.biomaterials.2024.122961","url":null,"abstract":"<div><div>Global aging heightens the risk of oral disorders, among which periodontitis is the major cause of tooth loss in the aging population. The regeneration of damaged periodontal hard tissue is highly challenging due to the existence of the refractory local inflammation. Owing to the potent anti-inflammatory capabilities, regulatory T cells hold great promise in immunotherapies for tissue regeneration. However, the transferred regulatory T cells can alter their phenotypes and functions in local inflammatory milieu, significantly impairing their therapeutic efficacy. Herein, we introduce a novel regulatory T cell-based nanobiohybrid system bearing polyphenol-functionalized rapamycin nanocomplexes. The sustained <em>in situ</em> release of immunosuppressant rapamycin from the cell-attached nanocomplexes maintains the anti-inflammatory phenotype of regulatory T cells in the inflammatory milieu. The synergistic actions of the anti-inflammatory cytokines secreted and the immunosuppressant released guide a pro-resolving polarization of macrophages and enhance osteogenic differentiation of bone marrow-derived stromal cells. The stabilized phenotype of the regulatory T cells dramatically promoted the resolution of periodontal inflammation and the repair of the hard tissue (alveolar bone) <em>in vivo</em>. Overall, these studies highlight a potent regulatory T cell-based nanobiohybrid therapy to treat periodontitis by modulating periodontal immune microenvironment.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122961"},"PeriodicalIF":12.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensorable zwitterionic antibacterial hydrogel for wound electrostimulation therapy 用于伤口电刺激疗法的可感应齐聚物抗菌水凝胶
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-09 DOI: 10.1016/j.biomaterials.2024.122958
Jinghua Li , Meijun Chen , Shaowen Cheng , Shegan Gao , Jingming Zhai , Dongmei Yu , Jianping Wang , Jianbo Zhang , Kaiyong Cai
{"title":"Sensorable zwitterionic antibacterial hydrogel for wound electrostimulation therapy","authors":"Jinghua Li ,&nbsp;Meijun Chen ,&nbsp;Shaowen Cheng ,&nbsp;Shegan Gao ,&nbsp;Jingming Zhai ,&nbsp;Dongmei Yu ,&nbsp;Jianping Wang ,&nbsp;Jianbo Zhang ,&nbsp;Kaiyong Cai","doi":"10.1016/j.biomaterials.2024.122958","DOIUrl":"10.1016/j.biomaterials.2024.122958","url":null,"abstract":"<div><div>Wound healing process has always been a focal point of concern, with a plethora of hydrogel dressings available; however, their therapeutic efficacy remains a hindrance to wound closure. This article reports on a dual-network conductive system, PEDOT:PSS-co-PSBMA/XLG (PPSX) hydrogel dressing, Constructed using poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT: PSS) in combination with zwitterionic N, N-dimethyl-N-(2-methacryloyloxyethyl)-N- (3-sulfopropyl) ammonium betaine (SBMA) and nanoclay-synthesized lithium magnesium silicate (XLG). The hydrogel powder produced from it can absorb interfacial water within 30 s via physical interactions to spontaneously form hydrogels of arbitrary shapes. With a conductivity of 1.8 s/m, it can be utilized for developing flexible sensing bioelectronic devices to monitor human activities (facial expressions, blinking, swallowing, speaking, joint movements), as well as constructing electrodes for monitoring muscle movements and motorial intensity. More importantly, PPSX hydrogel effectively inhibits bacterial growth and promotes cell proliferation, thus facilitating wound healing and presenting extensive application prospects in the medical field.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122958"},"PeriodicalIF":12.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On-demand reprogramming of immunosuppressive microenvironment in tumor tissue via multi-regulation of carcinogenic microRNAs and RNAs dependent photothermal-immunotherapy using engineered gold nanoparticles for malignant tumor treatment 利用工程金纳米粒子对致癌微RNA和RNA依赖性光热免疫疗法进行多调控,按需重编肿瘤组织中的免疫抑制微环境,用于恶性肿瘤治疗。
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-08 DOI: 10.1016/j.biomaterials.2024.122956
Li Chen , Wenjun Tang , Jie Liu , Man Zhu , Wenyun Mu , Xiaoyu Tang , Tao Liu , Zeren Zhu , Lin Weng , Yumeng Cheng , Yanmin Zhang , Xin Chen
{"title":"On-demand reprogramming of immunosuppressive microenvironment in tumor tissue via multi-regulation of carcinogenic microRNAs and RNAs dependent photothermal-immunotherapy using engineered gold nanoparticles for malignant tumor treatment","authors":"Li Chen ,&nbsp;Wenjun Tang ,&nbsp;Jie Liu ,&nbsp;Man Zhu ,&nbsp;Wenyun Mu ,&nbsp;Xiaoyu Tang ,&nbsp;Tao Liu ,&nbsp;Zeren Zhu ,&nbsp;Lin Weng ,&nbsp;Yumeng Cheng ,&nbsp;Yanmin Zhang ,&nbsp;Xin Chen","doi":"10.1016/j.biomaterials.2024.122956","DOIUrl":"10.1016/j.biomaterials.2024.122956","url":null,"abstract":"<div><div>The frequent immune escape of tumor cells and fluctuating therapeutic efficiency vary with each individual are two critical issues for immunotherapy against malignant tumor. Herein, we fabricated an intelligent core-shell nanoparticle (SNAs@CCM<sub>R</sub>) to significantly inhibit the PD-1/PD-L1 mediated immune escape by on-demand regulation of various oncogenic microRNAs and perform RNAs dependent photothermal-immunotherapy to achieve precise and efficient treatment meeting the individual requirements of specific patients by in situ generation of customized tumor-associated antigens. The SNAs@CCM<sub>R</sub> consisted of antisense oligonucleotides grafted gold nanoparticles (SNAs) as core and TLR7 agonist imiquimod (R837) functionalized cancer cell membrane (CCM) as shell, in which the acid-labile Schiff base bond was used to connect the R837 and CCM. During therapy, the acid environment of tumor tissue cleaved the Schiff base to generate free R837 and SNAs@CCM. The SNAs@CCM further entered tumor cells via CCM mediated internalization, and then specifically hybridized with over-expressed miR-130a and miR-21, resulting in effective inhibition of the migration and PD-L1 expression of tumor cells to avoid their immune escape. Meanwhile, the RNAs capture also caused significant aggregation of SNAs, which immediately generated photothermal agents within tumor cells to perform highly selective photothermal therapy under NIR irradiation. These chain processes not only damaged the primary tumor, but also produced plenty of tumor-associated antigens, which matured the surrounding dendritic cells (DCs) and activated anti-tumor T cells along with the released R837, resulting in the enhanced immunotherapy with suppressive immune escape. Both in vivo and in vitro experiments demonstrated that our nanoparticles were able to inhibit primary tumor and its metastasis via multi-regulation of carcinogenic microRNAs and RNAs dependent photothermal-immune activations, which provided a promising strategy to reprogram the immunosuppressive microenvironment in tumor tissue for better malignant tumor therapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122956"},"PeriodicalIF":12.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary delivery of dual-targeted nanoparticles improves tumor accumulation and cancer cell targeting by restricting macrophage interception in orthotopic lung tumors 双靶向纳米粒子的肺部给药通过限制巨噬细胞对正位肺肿瘤的拦截,改善了肿瘤积累和癌细胞靶向性。
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-08 DOI: 10.1016/j.biomaterials.2024.122955
Di Ge , Siqi Ma , Tingting Sun , Yunfei Li , Jiaxing Wei , Chenao Wang , Xiaoyuan Chen , Yonghong Liao
{"title":"Pulmonary delivery of dual-targeted nanoparticles improves tumor accumulation and cancer cell targeting by restricting macrophage interception in orthotopic lung tumors","authors":"Di Ge ,&nbsp;Siqi Ma ,&nbsp;Tingting Sun ,&nbsp;Yunfei Li ,&nbsp;Jiaxing Wei ,&nbsp;Chenao Wang ,&nbsp;Xiaoyuan Chen ,&nbsp;Yonghong Liao","doi":"10.1016/j.biomaterials.2024.122955","DOIUrl":"10.1016/j.biomaterials.2024.122955","url":null,"abstract":"<div><div>Despite the recognized potential of inhaled nanomedicines to enhance and sustain local drug concentrations for lung cancer treatment, the influence of macrophage uptake on targeted nanoparticle delivery to and within tumors remains unclear. Here, we developed three ligand-coated nanoparticles for pulmonary delivery in lung cancer therapy: phenylboronic acid-modified nanoparticles (PBA-NPs), PBA combined with folic acid (FA-PBA-NPs), and PBA with mannose (MAN-PBA-NPs). <em>In vitro,</em> MAN-PBA-NPs were preferentially internalized by macrophages, whereas FA-PBA-NPs exhibited superior uptake by cancer cells compared to macrophages. Following intratracheal instillation into mice with orthotopic Lewis lung carcinoma tumors, all three nanoparticles showed similar lung retention. However, MAN-PBA-NPs were more prone to interception by lung macrophages, which limited their accumulation in tumor tissues. In contrast, both PBA-NPs and FA-PBA-NPs achieved comparable high tumor accumulation (∼11.3% of the dose). Furthermore, FA-PBA-NPs were internalized by ∼30% of cancer cells, significantly more than the 10–18% seen with PBA-NPs or MAN-PBA-NPs. Additionally, FA-PBA-NPs loaded with icaritin effectively inhibited the Wnt/β-catenin pathway, resulting in superior anti-tumor efficacy through targeted cancer cell delivery. Overall, FA-PBA-NPs demonstrated advantageous competitive uptake kinetics by cancer cells compared to macrophages, enhancing tumor targeting and therapeutic outcomes.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122955"},"PeriodicalIF":12.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visible light-induced simultaneous bioactive amorphous calcium phosphate mineralization and in situ crosslinking of coacervate-based injectable underwater adhesive hydrogels for enhanced bone regeneration 可见光同时诱导具有生物活性的无定形磷酸钙矿化和基于共凝胶的可注射水下粘合水凝胶的原位交联,以促进骨再生。
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-07 DOI: 10.1016/j.biomaterials.2024.122948
Jinyoung Yun , Hyun Tack Woo , Sangmin Lee , Hyung Joon Cha
{"title":"Visible light-induced simultaneous bioactive amorphous calcium phosphate mineralization and in situ crosslinking of coacervate-based injectable underwater adhesive hydrogels for enhanced bone regeneration","authors":"Jinyoung Yun ,&nbsp;Hyun Tack Woo ,&nbsp;Sangmin Lee ,&nbsp;Hyung Joon Cha","doi":"10.1016/j.biomaterials.2024.122948","DOIUrl":"10.1016/j.biomaterials.2024.122948","url":null,"abstract":"<div><div>The field of bone tissue engineering is vital due to increasing bone disorders and limitations of traditional grafts. Injectable hydrogels offer minimally invasive solutions but often lack mechanical integrity and biological functionality, including osteoinductive capacity and structural stability under physiological conditions. To address these issues, we propose a coacervate-based injectable adhesive hydrogel that utilizes the dual functionality of <em>in situ</em> photocrosslinking and osteoinductive amorphous calcium phosphate formation, both of which are activated simultaneously by visible light irradiation. The developed hydrogel formulation integrated a photoreactive agent with calcium ions and phosphonodiol in a matrix of tyramine-conjugated alginate and RGD peptide-fused bioengineered mussel adhesive protein, promoting rapid setting, robust underwater adhesion, and bioactive mineral deposition. The hydrogel also exhibited superior mechanical properties, including enhanced underwater tissue adhesive strength and compressive resistance. <em>In vivo</em> evaluation using a rat femoral tunnel defect model confirmed the efficacy of the developed adhesive hydrogel in facilitating easy application to irregularly shaped defects through injection, rapid bone regeneration without the addition of bone grafts, and integration within the defect sites. This injectable adhesive hydrogel system holds significant potential for advancing bone tissue engineering, providing a versatile, efficient, and biologically favorable alternative to conventional bone repair methodologies.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122948"},"PeriodicalIF":12.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and treatment 用于癌症诊断和治疗的基于 COX-2 抑制剂的新兴纳米疗法。
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-07 DOI: 10.1016/j.biomaterials.2024.122954
Ruiping Huang , Jiang Yu , Baoyue Zhang , Xin Li , Hongzhuo Liu , Yongjun Wang
{"title":"Emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and treatment","authors":"Ruiping Huang ,&nbsp;Jiang Yu ,&nbsp;Baoyue Zhang ,&nbsp;Xin Li ,&nbsp;Hongzhuo Liu ,&nbsp;Yongjun Wang","doi":"10.1016/j.biomaterials.2024.122954","DOIUrl":"10.1016/j.biomaterials.2024.122954","url":null,"abstract":"<div><div>Increasing evidence has showed that tumorigenesis is closely linked to inflammation, regulated by multiple signaling pathways. Among these, the cyclooxygenase-2/prostaglandin E<sub>2</sub> (COX-2/PGE<sub>2</sub>) axis plays a crucial role in the progression of both inflammation and cancer. Inhibiting the activity of COX-2 can reduce PGE<sub>2</sub> secretion, thereby suppressing tumor growth. Therefore, COX-2 inhibitors are considered potential therapeutic agents for cancers. However, their clinical applications are greatly hindered by poor physicochemical properties and serious adverse effects. Fortunately, the advent of nanotechnology offers solutions to these limitations, enhancing drug delivery efficiency and mitigating adverse effects. Given the considerable progress in this area, it is timely to review emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and therapy. In this review, we first outline the various antineoplastic mechanisms of COX-2 inhibitors, then comprehensively summarize COX-2 inhibitors-based nanotherapeutics for cancer monotherapy, combination therapy, and diagnosis. Finally, we highlight and discuss future perspectives and challenges in the development of COX-2 inhibitors-based nanomedicine.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122954"},"PeriodicalIF":12.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A precision intelligent nanomissile for inhibiting tumor metastasis, boosting energy deprivation and immunotherapy 用于抑制肿瘤转移、增强能量剥夺和免疫疗法的精密智能纳米导弹。
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-07 DOI: 10.1016/j.biomaterials.2024.122953
Shan Gao , Meng Liu , Yu Zhang , Zhijing He , Yingying Li , Jianbo Ji , Lei Ye , Xiaoye Yang , Guangxi Zhai
{"title":"A precision intelligent nanomissile for inhibiting tumor metastasis, boosting energy deprivation and immunotherapy","authors":"Shan Gao ,&nbsp;Meng Liu ,&nbsp;Yu Zhang ,&nbsp;Zhijing He ,&nbsp;Yingying Li ,&nbsp;Jianbo Ji ,&nbsp;Lei Ye ,&nbsp;Xiaoye Yang ,&nbsp;Guangxi Zhai","doi":"10.1016/j.biomaterials.2024.122953","DOIUrl":"10.1016/j.biomaterials.2024.122953","url":null,"abstract":"<div><div>The epithelial-mesenchymal transition (EMT), tumor stroma and local metabolic alterations cooperate to establish a unique tumor microenvironment (TME) that fosters tumor progression and metastasis. To tackle this challenge, a precision intelligent nanomissile named HA@AT-Pd has been designed for dual-pronged cancer-associated fibroblast (CAF) transformation and tumor cell elimination. It is observed that HA@AT-Pd inhibits the production of cancer stem cells (CSCs) by blocking the TGF-β/Smad signaling pathway-mediated EMT and reversing activated CAFs to quiescence. Notably, HA@AT-Pd induces energy depletion in breast cancer cells through simultaneously suppressing cellular oxidative phosphorylation and glycolysis. The inhibition of glycolysis results in reduced lactic acid production, thereby converting an immunosuppressive TME into an immune-activating environment. Furthermore, the photothermal effect generated by HA@AT-Pd evokes immunogenic cell death, which can further enhance the anti-tumor immune response. Overall, this multifunctional combination strategy unveils potential therapeutic avenues to inhibit tumor progression and metastasis.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122953"},"PeriodicalIF":12.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aggregation-induced emission-based phototheranostics to combat bacterial infection at wound sites: A review 基于聚集诱导发射的光otheranostics,用于抗击伤口处的细菌感染:综述。
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-06 DOI: 10.1016/j.biomaterials.2024.122950
Zhurun Fang , Shixuan Zhang , Wentao Wang , Yan Xu , Mengmeng Lu , Yuxin Qian , Xiyan Xiao , Yuanyuan Li , Ben Zhong Tang , Ming Zhang
{"title":"Aggregation-induced emission-based phototheranostics to combat bacterial infection at wound sites: A review","authors":"Zhurun Fang ,&nbsp;Shixuan Zhang ,&nbsp;Wentao Wang ,&nbsp;Yan Xu ,&nbsp;Mengmeng Lu ,&nbsp;Yuxin Qian ,&nbsp;Xiyan Xiao ,&nbsp;Yuanyuan Li ,&nbsp;Ben Zhong Tang ,&nbsp;Ming Zhang","doi":"10.1016/j.biomaterials.2024.122950","DOIUrl":"10.1016/j.biomaterials.2024.122950","url":null,"abstract":"<div><div>The healing of chronic wounds infected by bacteria has attracted increasing global concerns. In the past decades, antibiotics have certainly brought hope to cure bacteria-infected chronic wounds. However, the misuse of antibiotics leads to the emergence of numerous multidrug-resistant bacteria, which aggravate the health threat to clinical patients. To address these increasing challenges, scientists are committed to creating novel non-antibiotic strategies to kill bacteria and promote bacteria-infected chronic wound healing. Fortunately, with the quick development of nanotechnology, the representatives of phototherapy, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit promising possibilities in promoting bacteria-infected wound healing. Well-known, photothermal agents and photosensitizers largely determine the effects of PTT and PDT. A common problem for these molecules is the aggregation-induced quenching effect, which highly limits their further applicability in biomedical and clinical fields. Fortunately, the occurrence of aggregation-induced emission luminogens (AIEgens) efficiently overcomes the photobleaching and exhibit advantages, such as strongly aggregated emission, superior photostability, aggregation-enhanced reactive oxygen species (ROS), and heat generation, which makes great sense to the development of PTT and PDT. This article reviews various studies conducted on novel AIEgen-based materials that can mediate potent PDT, PTT, and a combination of PDT and PTT to promote bacteria-infected chronic wound healing.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122950"},"PeriodicalIF":12.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered VNP20009 expressing IL-15&15Rα augments anti-tumor immunity for bladder cancer treatment 表达 IL-15&15Rα 的工程 VNP20009 增强了治疗膀胱癌的抗肿瘤免疫力。
IF 12.8 1区 医学
Biomaterials Pub Date : 2024-11-06 DOI: 10.1016/j.biomaterials.2024.122951
Bo Liu , Kaiwei Wang , Qiaofeng Li , Zhisheng Xiao , Zihao Chen , Yuting Zhang , Yuzhe Wu , Yuchun Xu , Yumin Wu , Zhuang Liu
{"title":"Engineered VNP20009 expressing IL-15&15Rα augments anti-tumor immunity for bladder cancer treatment","authors":"Bo Liu ,&nbsp;Kaiwei Wang ,&nbsp;Qiaofeng Li ,&nbsp;Zhisheng Xiao ,&nbsp;Zihao Chen ,&nbsp;Yuting Zhang ,&nbsp;Yuzhe Wu ,&nbsp;Yuchun Xu ,&nbsp;Yumin Wu ,&nbsp;Zhuang Liu","doi":"10.1016/j.biomaterials.2024.122951","DOIUrl":"10.1016/j.biomaterials.2024.122951","url":null,"abstract":"<div><div>Surgical resection combined with intravesical instillation of chemotherapeutics or Bacillus Calmette-Guerin (BCG) to remove residual cancer cells is the gold standard for the clinical treatment of patients with bladder cancer. In a recent clinical trial, a new super-agonist complex of IL-15 - N803, has shown promising results when used in combination with BCG to treat patients with bladder cancer who do not respond to BCG. Herein, we used temperature-controlled pBV220 plasmid encoding Interleukin-15 and its receptor alpha subunit (IL-15&amp;15Rα) to transform VNP20009, an attenuated salmonella typhimurium strain, obtaining engineered bacteria named 15&amp;15Rα@VNP. After induction at 42 °C, 15&amp;15Rα@VNP can secrete functional IL-15&amp;15Rα stably. It was found that intravesical instillation of thermally activated 15&amp;15Rα@VNP could inhibit the growth of bladder tumors if used alone. Moreover, the sequential intravesical instillation of epirubicin (EPI), a first-line bladder cancer drug, followed by thermally activated 15&amp;15Rα@VNP, could achieve further improved therapeutic responses, without causing significant side effects. Therefore, this study shows that 15&amp;15Rα@VNP can be effectively used in the treatment of bladder cancer and can be used as a complementary therapy to chemotherapy agents, promising for potential clinical translation in bladder cancer treatment.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122951"},"PeriodicalIF":12.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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