Biomaterials最新文献

{"title":"Surface-functionalized bacteria: Frontier explorations in next-generation live biotherapeutics.","authors":"Jia-Ni Jiang, Fan-Hui Kong, Qi Lei, Xian-Zheng Zhang","doi":"10.1016/j.biomaterials.2024.123029","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123029","url":null,"abstract":"<p><p>Screening robust living bacteria to produce living biotherapeutic products (LBPs) represents a burgeoning research field in biomedical applications. Despite their natural abilities to colonize bio-interfaces and proliferate, harnessing bacteria for such applications is hindered by considerable challenges in unsatisfied functionalities and safety concerns. Leveraging the high degree of customization and adaptability on the surface of bacteria demonstrates significant potential to improve therapeutic outcomes and achieve tailored functionalities of LBPs. This review focuses on the recent laboratory strategies of bacterial surface functionalization, which aims to address these challenges and potentiate the therapeutic effects in biomedicine. Firstly, we introduce various functional materials that are used for bacterial surface functionalization involving organic, inorganic, and biological materials. Secondly, the methodologies for achieving bacterial surface functionalization are categorized into three primary approaches including covalent bonding, non-covalent interactions, and hybrid techniques, while various advantages and limitations of different modification strategies are compared from multiple perspectives. Subsequently, the current status of the applications of surface-functionalized bacteria in bioimaging and disease treatments, especially in the treatment of inflammatory bowel disease (IBD) and cancer is summarized. Finally, challenges and pressing issues in the development of surface-functionalized bacteria as LBPs are presented.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"317 ","pages":"123029"},"PeriodicalIF":12.8,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LIFU-unlocked endogenous H2S generation for enhancing atherosclerosis-specific gas-enzymatic therapy","authors":"Hongjin An ,&nbsp;Xiaoling Qiu ,&nbsp;Xiaoting Wang ,&nbsp;Chier Du ,&nbsp;Xun Guo ,&nbsp;Shengzhe Hou ,&nbsp;Min Xu ,&nbsp;Jingxue Wang ,&nbsp;Chen Cheng ,&nbsp;Haitao Ran ,&nbsp;Pan Li ,&nbsp;Zhigang Wang ,&nbsp;Zhiyi Zhou ,&nbsp;Jianli Ren ,&nbsp;Weixi Jiang","doi":"10.1016/j.biomaterials.2024.122972","DOIUrl":"10.1016/j.biomaterials.2024.122972","url":null,"abstract":"<div><div>Atherosclerotic plaques, which are characterized by endothelial oxidative stress, lipid metabolism disorders and persistent inflammation, can induce serious cardiovascular diseases. However, the pharmacotherapies currently used to treat atherosclerosis (AS), such as lipid-lowering and antithrombotic drugs, can regulate only a single pathological feature of AS, and there is still a dearth of integrated platforms for the multifaceted regulation of AS progression. Herein, we developed a synergistic combination of endogenous H₂S gas therapy with a multienzyme-like nanozyme (named ^LyP−1Lip@HS) for the treatment of AS. The high affinity of the LyP-1 peptide for macrophages and foam cells within plaques allows ^LyP−1Lip@HS to actively target atherosclerotic lesions. After cavitation was induced by low-intensity focused ultrasound (LIFU), the lipid membrane of ^LyP−1Lip@HS was disrupted, thereby \"unlocking\" the enzyme-like activity of hollow mesoporous Prussian blue (HMPB) and facilitating the release of the endogenous H₂S donor S-allyl-L-cysteine (SAC). Notably, H₂S endogenously generated by enzymatic catalysis plays multiple roles, upregulating the ATP-binding cassette transporter A1 in foam cells to increase lipid efflux and promote the conversion of M1 macrophages to M2 macrophages. Moreover, the high level of reactive oxygen species in the inflammatory microenvironment of the plaque was mitigated. Overall, ^LyP−1Lip@HS provides a specific and controlled treatment to prevent oxidative stress, inflammation and lipid metabolism disorders, making it a candidate for AS treatment.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122972"},"PeriodicalIF":12.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable and adhesive MgO2-potentiated hydrogel with sequential tumor synergistic therapy and osteogenesis for challenging postsurgical osteosarcoma treatment","authors":"Wenjing Zhang ,&nbsp;Long Li ,&nbsp;Zishuo Wang ,&nbsp;Yangyi Nie ,&nbsp;Yipei Yang ,&nbsp;Cairong Li ,&nbsp;Yuyang Zhang ,&nbsp;Yuxi Jiang ,&nbsp;Yuhui Kou ,&nbsp;Wei Zhang ,&nbsp;Yuxiao Lai","doi":"10.1016/j.biomaterials.2024.122959","DOIUrl":"10.1016/j.biomaterials.2024.122959","url":null,"abstract":"<div><div>The clinical treatment of osteosarcoma faces great challenges of residual tumor cells leading to tumor recurrence and irregular bone defects difficult to repair after surgery removal of the primary tumor tissue. We developed an injectable and <em>in-situ</em> cross-linkable hydrogel (named MOG hydrogel) using MgO₂ nanoparticles and dopamine-conjugated gelatin as main components. MgO₂ was rationally designed as a multifunctional active ingredient to mediate <em>in situ</em> gelation, tumor therapy, and bone repair sequentially. The 10MOG (with 10 mg/mL MgO₂ content) showed excellent gel stability, injectability, shape adaptability, tissue adhesion, and rapid hemostatic ability. Importantly, 10MOG exhibited ideal sequential H₂O₂ and Mg²⁺ release property. The released H₂O₂ synergized with photothermal therapy for enhanced tumor recurrence suppression, and the sustainable Mg²⁺ release efficiently promoted bone regeneration. The MOG hydrogel, possessing excellent on-demand antitumor and osteogenic capabilities <em>in vitro</em> and <em>in vivo</em>, exhibited tremendous potential in the clinical application for challenging postsurgical osteosarcoma treatment.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122959"},"PeriodicalIF":12.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsive plasmonic hybrid nanorods enables metabolism reprogramming via cuproptosis-photothermal combined cancer therapy","authors":"Qian Xie ,&nbsp;Tao Sun ,&nbsp;Liang Zhang ,&nbsp;Mingfu Gong ,&nbsp;Wansu Zhang ,&nbsp;Xu Liu ,&nbsp;Yue Zhao ,&nbsp;Miaomiao Wang ,&nbsp;Xiaofeng Yang ,&nbsp;Zhipeng Zhang ,&nbsp;Gang Liu ,&nbsp;Chunyu Zhou ,&nbsp;Dong Zhang","doi":"10.1016/j.biomaterials.2024.122971","DOIUrl":"10.1016/j.biomaterials.2024.122971","url":null,"abstract":"<div><div>Abnormal tumor metabolism leads to tumor growth, metastasis, and recurrence, reprogramming tumor metabolism and activating potent anti-tumor immune response have been demonstrated to have good therapeutic effects on tumor elimination. Copper-based nanomaterials involved in cuproptosis show great prospects in these two aspects, but their efficiency is restricted by Cu homeostasis and the toxicity of the chelator. Here, the pH-responsive AuNRs@Cu₂O core-shell plasmonic hybrid nanorods (ACNRs) have been successfully fabricated to realize microenvironment-controlled release at the tumor site for the combined therapy of cuproptosis and photothermal treatment. The AuNRs core exhibited excellent NIR-II photothermal property, which boost the intracellular concentration of copper to trigger severe cuproptosis and induce immunogenic cell death of tumor cells. <em>In vivo</em> studies demonstrated the ACNR exhibited efficient tumor therapy for primary, metastatic, and recurrent tumors. ACNRs-induced cuproptosis and PTT were capable of reprogramming energy metabolism, leading to a decreased production of lactic acid. This potential of metabolic reprogramming assisted in reshaping the immunosuppressive tumor microenvironment to facilitate the infiltration of immune cells and boost the immune responses triggered by PTT. The therapeutic mechanism was further verified by metabolomics analysis, which indicated that ACNRs + PTT treatment led to the inhibition of the Pentose Phosphate Pathway and Glycolysis pathways in tumor cells. The suppression of glycolytic reduced ATP synthesis, thereby hindering energy-dependent copper efflux, which in turn promoted cuproptosis. Taken together, this study offers promising insights for cuproptosis-based cancer treatment and sheds new light on nanomedicine-mediated metabolic modulation for future tumor therapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122971"},"PeriodicalIF":12.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remolding probiotics for effective treatment of type 2 diabetes via oral administration","authors":"Haihua Ji ,&nbsp;Yiqun Wan ,&nbsp;Shengjie Li ,&nbsp;Dexi Zhou ,&nbsp;Fengying Gu ,&nbsp;Jiajiu Sun ,&nbsp;Xiaochen Yan ,&nbsp;Yu Le ,&nbsp;Tingtao Chen ,&nbsp;Shaoping Nie ,&nbsp;Hao Wan","doi":"10.1016/j.biomaterials.2024.122970","DOIUrl":"10.1016/j.biomaterials.2024.122970","url":null,"abstract":"<div><div>Effective, user-friendly, lifestyle-compatible, and economic treatment for type 2 diabetes (T2D) is urgently needed due to its high incidence and health threats. Here, we remolded <em>Lactococcus lactis</em> through genetic engineering to persistently secrete glucagon-like peptide-1 <strong>(</strong><em>L. lactis</em>-GLP-1<strong>)</strong> and subsequent bioorthogonal arming with dopamine (DA)-based “gripper” and β-glucan (GN)-based “shield” (<em>L. lactis</em>-GLP-1-DA@GN) for treatment of T2D mice via oral administration. With protection by GN-based “shield”, <em>L. lactis</em>-GLP-1-DA@GN achieved an impressive enhancement of survival by 20666 times compared with bare <em>L. lactis</em>-GLP-1 after experiencing gastrointestinal conditions and DA-based “gripper” was shielded from interaction with the upper digestive tract. Once prebiotic GN was metabolized by gut microbiota into short-chain fatty acids (SCFAs), underlying DA-based “gripper” was exposed to assist intestinal colonization of <em>L. lactis</em>-GLP-1, achieving synergistic treatment effects through secreted GLP-1 and SCFAs. With all advances, oral administration of <em>L. lactis</em>-GLP-1-DA@GN realized effective T2D treatment through improving glucose/lipid homeostasis, repairing major organs' damages, and positively modulating gut microbiota. Moreover, multi-omics analysis revealed that <em>L. lactis</em>-GLP-1-DA@GN also mainly intervened in liver's signaling pathways regarding lipid metabolism and oxidative regulation to advance anti-T2D process. Our strategy marks reconstruction of probiotics by combining chemical and biological tools, broadening the avenue of manipulating probiotics for disease treatments.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122970"},"PeriodicalIF":12.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A NIR-II emissive sonosensitized biotuner for pyroptosis-enhanced sonodynamic therapy of hypoxic tumors","authors":"Xiaoyu Wang ,&nbsp;Weijie Chi ,&nbsp;Jiao Wu ,&nbsp;Jingwen Zou ,&nbsp;Jiyoung Yoo ,&nbsp;Seokjin Hong ,&nbsp;Fan Zhang ,&nbsp;Zhiqiang Mao ,&nbsp;Jong Seung Kim","doi":"10.1016/j.biomaterials.2024.122969","DOIUrl":"10.1016/j.biomaterials.2024.122969","url":null,"abstract":"<div><div>Pyroptosis is considered as a new way to effectively boost the immune response of tumors and inhibit tumor growth. Effective strategies to induce pyroptosis mainly rely on chemotherapeutic drugs and phototherapy, but their potential biotoxicity and phototoxicity limit their application in biomedicine. Herein, we designed a NIR-II emitting pyroptosis biotuner, <strong>Rd-TTPA</strong>, which induced pyroptosis under ultrasound irradiation to achieve pyroptosis-enhanced sonodynamic therapy (SDT) and immunogenic cell death (ICD) for tumors. Benefiting from its A-π-D₁-D₂ structure enhanced donor-acceptor interaction, <strong>Rd-TTPA</strong> can induce cell pyroptosis under both normoxia (21 % O₂) and hypoxia (2 % O₂) conditions by rapidly generating superoxide radicals (O₂^−•) upon ultrasound irradiation. The sonodynamic biotuner of pyroptosis overcomes the longstanding weakness of chemical drug and photosensitizer-based pyroptosis, such as drug resistance and limited penetration depth. In-depth studies demonstrated that <strong>Rd-TTPA</strong> can selectively target tumor cell mitochondria and possess excellent <em>in vivo</em> NIR-II fluorescence imaging capabilities. Administrating a tumor-bearing mouse model with <strong>Rd-TPPA</strong>, satisfying antitumor efficacy <em>via</em> pyroptosis-augmented SDT was achieved upon the guidance of NIR-II fluorescence imaging.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122969"},"PeriodicalIF":12.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-propelling intelligent nanomotor: A dual-action photothermal and starvation strategy for targeted deep tumor destruction","authors":"Ling Mei ,&nbsp;Qihang Ding ,&nbsp;Yuxin Xie ,&nbsp;Haowei Liu ,&nbsp;Hongping Li ,&nbsp;Eunji Kim ,&nbsp;Xue Shen ,&nbsp;Yibin Zhang ,&nbsp;Shuai Zhang ,&nbsp;Jong Seung Kim","doi":"10.1016/j.biomaterials.2024.122968","DOIUrl":"10.1016/j.biomaterials.2024.122968","url":null,"abstract":"<div><div>Delivering nanoparticles to deep tumor tissues while maintaining high therapeutic efficacy and minimizing damage to surrounding tissues has long posed a significant challenge. To address this, we have developed innovative self-propelling bowl-shaped nanomotors MSLA@GOx-PDA composed of mesoporous silica loaded with <span><em>l</em></span>-arginine and polydopamine, along with glucose oxidase (GOx). These nanomotors facilitate the generation of hydrogen peroxide through GOx-catalyzed glucose oxidation, thereby initiating nitric oxide production from <span><em>l</em></span>-arginine. This dual mechanism equips MSLA@GOx-PDA with the robust motility required for deep tumor tissue penetration while depleting essential nutrients necessary for tumor growth, consequently impeding tumor progression. In addition, near-infrared lasers have the significant advantage of being depth-penetrating and non-invasive, allowing real-time fluorescence imaging and guiding dopamine-mediated mild photothermal therapy. Notably, starvation therapy depletes intracellular adenosine triphosphate and inhibits the synthesis of heat shock proteins, thus overcoming the Achilles' heel of mild photothermal therapy and significantly enhancing the efficacy of this therapy with encouraging synergistic anti-tumour effects. Overall, the integration of biochemical and optics strategies in this nanomotor platform represents a significant advancement in deep-tissue tumor therapy. It has substantial clinical translational value and is expected to have a transformative impact on future cancer treatments.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122968"},"PeriodicalIF":12.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histamine receptor agonism differentially induces immune and reparative healing responses in biomaterial-facilitated tissue repair","authors":"Jordan R. Yaron ,&nbsp;Shubham Pallod ,&nbsp;Nicole Grigaitis-Esman ,&nbsp;Vanshika Singh ,&nbsp;Samantha Rhodes ,&nbsp;Dirghau Manishbhai Patel ,&nbsp;Deepanjan Ghosh ,&nbsp;Kaushal Rege","doi":"10.1016/j.biomaterials.2024.122967","DOIUrl":"10.1016/j.biomaterials.2024.122967","url":null,"abstract":"<div><div>Tissue repair is a highly regulated process involving immune, stromal, vascular, and parenchymal cell responses. Mediators of cellular responses at different phases of the healing process stimulate transitions through the continuum of repair. Histamine is an early mediator of healing, which, in skin, is released by resident cells (e.g., mast cells) after cutaneous injury, and acts to stimulate diverse responses in multiple cell populations. Histamine signaling is regulated by four distinct cell surface G-protein coupled receptors (HRH1-4 in humans, Hrh1-4 in mice) which initiate different downstream signaling cascades upon activation, but the specific effect of each receptor on tissue repair is poorly understood. Here, we systematically investigated the effect of selective histamine receptor agonism in laser-activated sealing and tissue repair of incisional skin wounds in immunocompetent mice. Although all four histamine receptors exhibited wound responsiveness in the epidermis, we find that activation of Hrh1, Hrh2, and Hrh4 stimulate a pro-healing immune response characterized by increased pro-resolution macrophages, reduced pro-inflammatory macrophages, and suppressed neutrophil responses. Further, activation of Hrh1 and Hrh4 stimulate angiogenesis after injury. Lastly, although Hrh1 activation resulted in enhanced epidermal epithelial-to-mesenchymal transition (EMT) <em>in vivo</em> and epithelialization <em>in vitro</em>, activation of Hrh2 suppressed both epidermal EMT and epithelialization. Activation of Hrh3, primarily found on neuronal cells, had no effect on any measure in our study. Selective histamine receptor agonism, specifically of histamine receptors Hrh-1 and 4, is a potential reparative approach to promote the efficacy of biomaterial-mediated repair of tissues, including skin.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122967"},"PeriodicalIF":12.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse","authors":"Darnell L. Cuylear ,&nbsp;Moyu L. Fu ,&nbsp;Justin C. Chau ,&nbsp;David Bulkley ,&nbsp;Bhushan Kharbikar ,&nbsp;Galateia J. Kazakia ,&nbsp;Andrew H. Jheon ,&nbsp;Stefan Habelitz ,&nbsp;Sunil D. Kapila ,&nbsp;Tejal A. Desai","doi":"10.1016/j.biomaterials.2024.122965","DOIUrl":"10.1016/j.biomaterials.2024.122965","url":null,"abstract":"<div><div>Orthodontic relapse is one of the most prevalent concerns of orthodontic therapy. Relapse results in patients' teeth reverting towards their pretreatment positions, which increases the susceptibility to functional problems, dental disease, and substantially increases the financial burden for retreatment. This phenomenon is thought to be induced by rapid remodeling of the periodontal ligament (PDL) in the early stages and poor bone quality in the later stages. Current therapies including fixed or removable retainers and fiberotomies have limitations with patient compliance and invasiveness. Approaches using biocompatible biomaterials, such as calcium phosphate polymer-induced liquid precursors (PILP), are an ideal translational approach for minimizing orthodontic relapse. Here, post-orthodontic relapse is reduced after a single injection of high concentration PILP (HC-PILP) nanoclusters by altering PDL remodeling in the early stage of relapse and improving trabecular bone quality in the later stage. HC-PILP nanoclusters are achieved by using high molecular weight poly aspartic acid (PASP, 14 kDa) and poly acrylic acid (PAA, 450 kDa), which resulted in a stable solution of high calcium and phosphate concentrations without premature precipitation. <em>In vitro</em> results show that HC-PILP nanoclusters prevented collagen type-I mineralization, which is essential for the tooth-PDL-bone interphase. <em>In vivo</em> experiments show that the HC-PILP nanoclusters minimize relapse and improve the trabecular bone quality in the late stages of relapse. Interestingly, HC-PILP nanoclusters also altered the remodeling of the PDL collagen during the early stages of relapse. Further <em>in vitro</em> experiments showed that HC-PILP nanoclusters alter the fibrillogenesis of collagen type-I by impacting the protein secondary structure and forming aggregates. These findings propose a new approach for treating orthodontic relapse and provide additional insight into the PILP nanocluster's structure and properties on collagenous structure repair.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122965"},"PeriodicalIF":12.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming tumor hypoxic bismuth-based ternary heterojunctions enable defect modulation-augmented tumor sonocatalytic immunotherapy","authors":"Zongyan He ,&nbsp;Qian Wang ,&nbsp;Jun Du ,&nbsp;Sijia Wu ,&nbsp;Qing Miao ,&nbsp;Yuhao Li ,&nbsp;Yuqing Miao ,&nbsp;Jingxiang Wu","doi":"10.1016/j.biomaterials.2024.122962","DOIUrl":"10.1016/j.biomaterials.2024.122962","url":null,"abstract":"<div><div>Inducing reactive oxygen species (ROS) via sonocatalysis to initiate inflammatory programmed cell death (PANoptosis) and immunogenic cell death (ICD) presents a promising strategy for activatable cancer immunotherapy. However, the limited ROS generation by sonosensitizers under ultrasound and the immunosuppressive tumor microenvironment hinder the efficiency of sono-immunotherapy. To overcome these challenges, a bismuth-based ternary heterojunction, Bi@Bi₂O₃–Pt-PEG (BBOP), was developed for sonocatalytic therapy aimed at activating immune responses. This system enhances ROS production during sonocatalysis and leverages dual therapeutic mechanisms by inducing PANoptosis and ICD to achieve improved anti-tumor efficacy. BBOP forms a Z-scheme heterojunction and Schottky contact through the formation of an intermediate Bi₂O₃ layer and the introduction of Pt. These structures significantly enhance sonocatalytic activity, while the Pt nanozyme exhibits catalase-like behavior, supplying oxygen for sonocatalysis, boosting ROS generation, and effectively relieving tumor hypoxia to reduce immune suppression. Further <em>in vitro</em> and <em>in vivo</em> experiments confirmed BBOP's ability to activate immune responses under ultrasound, inhibiting tumor growth and metastasis. RNA sequencing revealed the therapeutic biological mechanisms. The construction of this catalytic system not only provides insights for optimizing sonosensitizers but also offers a safer and more effective sono-immunotherapy activation strategy and theoretical basis for clinical cancer treatment.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"315 ","pages":"Article 122962"},"PeriodicalIF":12.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}