Biomaterials最新文献_第8页

Synergistic microglial modulation by laminarin-based platinum nanozymes for potential intracerebral hemorrhage therapy 基于层粘连素的铂纳米酶对小胶质细胞的协同调节可用于潜在的脑出血治疗

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-24 DOI: 10.1016/j.biomaterials.2025.123212

Xiumei Guo , Qionghua Zheng , Wen Gao , Yinfeng Xiao , Liyong Shi , Fenglin Lin , Yu Xiong , Yin Zhang , Qiuxia Xu , Lingxing Wang , Shaobin He , Feng Zheng

{"title":"Synergistic microglial modulation by laminarin-based platinum nanozymes for potential intracerebral hemorrhage therapy","authors":"Xiumei Guo , Qionghua Zheng , Wen Gao , Yinfeng Xiao , Liyong Shi , Fenglin Lin , Yu Xiong , Yin Zhang , Qiuxia Xu , Lingxing Wang , Shaobin He , Feng Zheng","doi":"10.1016/j.biomaterials.2025.123212","DOIUrl":"10.1016/j.biomaterials.2025.123212","url":null,"abstract":"<div><div>Abnormal microglial activation increases inflammation, causing significant brain damage after intracerebral hemorrhage (ICH). To aid recovery, treatments should regulate oxidative stress and inhibit the M1-like phenotype (pro-inflammation) of microglia. Recently, antioxidant nanozymes have emerged as tools for modulating microglial states, but detailed studies on their role in ICH treatment are limited. To address this, we developed an ultra-small (3–4 nm) laminarin-modified platinum nanozyme (Pt@LA) for the synergistic regulation of microglial polarization, offering a novel therapeutic strategy for ICH. Pt@LA effectively scavenges reactive oxygen species (ROS) through superoxide dismutase (SOD) and catalase (CAT)-like activities. Laminarin may inhibit the Dectin-1 receptor on microglia and its inflammatory pathway, Syk/NF-κB, reducing neuroinflammation. In vitro, Pt@LA decreased pro-inflammatory microglia and cytokine expression by inhibiting the Dectin-1/Syk/NF-κB and ROS-mediated NF-κB pathways. Furthermore, Pt@LA protected neurons, inhibited glial scar formation, and improved neurological function in ICH rats. Overall, this study presents Pt nanozymes based on naturally extracted laminarin and explores their application in alleviating oxidative stress and neuroinflammation after ICH, bridging nanozyme research and neuroscience.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"319 ","pages":"Article 123212"},"PeriodicalIF":12.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-orthogonal-labeled exosomes reveals specific distribution in vivo and provides potential application in ARDS therapy 生物正交标记外泌体揭示了其在体内的特异性分布，并为 ARDS 治疗提供了潜在的应用前景

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-24 DOI: 10.1016/j.biomaterials.2025.123208

Song Yang , Haomiao Zhu , Hongzhen Jin , Kun Wang , Junna Song , Na Sun , Yonghui Liu , Xiaona Yin , Rui Wang , Xiao Wu , Huadong Liu , Chunling Zhang , Wei Zhao , Fan Yu

{"title":"Bio-orthogonal-labeled exosomes reveals specific distribution in vivo and provides potential application in ARDS therapy","authors":"Song Yang , Haomiao Zhu , Hongzhen Jin , Kun Wang , Junna Song , Na Sun , Yonghui Liu , Xiaona Yin , Rui Wang , Xiao Wu , Huadong Liu , Chunling Zhang , Wei Zhao , Fan Yu","doi":"10.1016/j.biomaterials.2025.123208","DOIUrl":"10.1016/j.biomaterials.2025.123208","url":null,"abstract":"<div><div>Exosomes derived from specific cells may be useful for targeted drug delivery, but tracking them <em>in vivo</em> is essential for their clinical application. However, their small size and complex structure challenge the development of exosome-tracking techniques, and traditional labeling methods are limited by weak affinity and potential toxicity. To address these issues, here we developed a novel bio-orthogonal labeling strategy based on phosphatidylinositol derivatives to fluorescently label exosomes from various human and mouse cell types. The different cell-derived exosomes revealed organ-specific distribution patterns and a favorable safety profile. Notably, 4T1 cell-derived exosomes specifically targeted the lungs. When used as drug carriers loaded with anti-inflammatory resveratrol, these exosomes showed significant therapeutic efficacy in mice with acute respiratory distress syndrome (ARDS), effectively reducing inflammatory responses, mitigating pulmonary fibrosis, and restoring lung tissue morphology and function. Our findings provide a novel exosome labeling strategy and an invaluable tool for their <em>in vivo</em> tracking and targeting screening, while exosomes that specifically target the lungs offer a potential therapeutic strategy for organ-specific diseases such as ARDS.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"319 ","pages":"Article 123208"},"PeriodicalIF":12.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision delivery of pretreated macrophage-membrane-coated Pt nanoclusters for improving Alzheimer's disease-like cognitive dysfunction induced by Porphyromonas gingivalis

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-24 DOI: 10.1016/j.biomaterials.2025.123211

Kang Liu , Xuejing Ma , Yifei Zhang , Liang Zhao , Yijie Shi

{"title":"Precision delivery of pretreated macrophage-membrane-coated Pt nanoclusters for improving Alzheimer's disease-like cognitive dysfunction induced by Porphyromonas gingivalis","authors":"Kang Liu , Xuejing Ma , Yifei Zhang , Liang Zhao , Yijie Shi","doi":"10.1016/j.biomaterials.2025.123211","DOIUrl":"10.1016/j.biomaterials.2025.123211","url":null,"abstract":"<div><div>Oral infection with Porphyromonas gingivalis (P. gingivalis), a kind of pathogenic bacteria causing periodontitis, can increase the risk of Alzheimer's disease (AD) and cause cognitive decline. Therefore, precise intracerebral antimicrobial therapy to reduce the load of P. gingivalis in brain may serve as a potential therapeutic approach to improve AD-like cognitive impairment. A kind of nano-delivery system precisely targets bacteria in the brain through coating P. gingivalis stimulated macrophage membrane onto the surface of platinum nanoclusters (Pg-M-PtNCs). Approximate 50 nm spherical Pg-M-PtNCs demonstrate good biocompatibility and the pretreated macrophage membranes can inhibit macrophages phagocytosis and increase the adherence to bacteria. Pg-M-PtNCs can significantly inhibit the growth of P.gingivalis in vitro, and are effectively delivered and remain at the infection site in the mice brain to reduce the bacterial load and neuronal damage, and then improve the AD-like cognitive dysfunction in the chronic periodontitis mice. Platinum nanoclusters coated with P. gingivalis pretreated macrophage membrane play an important role in targeting bacteria in the brain, and effectively improve AD-like cognitive function disorder caused by P. gingivalis infection in the brain.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"319 ","pages":"Article 123211"},"PeriodicalIF":12.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic vascular graft that heals and regenerates

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-24 DOI: 10.1016/j.biomaterials.2025.123206

Le Zhen , Elina Quiroga , Sharon A. Creason , Ningjing Chen , Tanmay R. Sapre , Jessica M. Snyder , Sarah L. Lindhartsen , Brendy S. Fountaine , Michael C. Barbour , Syed Faisal , Alberto Aliseda , Brian W. Johnson , Jonathan Himmelfarb , Buddy D. Ratner

{"title":"Synthetic vascular graft that heals and regenerates","authors":"Le Zhen , Elina Quiroga , Sharon A. Creason , Ningjing Chen , Tanmay R. Sapre , Jessica M. Snyder , Sarah L. Lindhartsen , Brendy S. Fountaine , Michael C. Barbour , Syed Faisal , Alberto Aliseda , Brian W. Johnson , Jonathan Himmelfarb , Buddy D. Ratner","doi":"10.1016/j.biomaterials.2025.123206","DOIUrl":"10.1016/j.biomaterials.2025.123206","url":null,"abstract":"<div><div>Millions of synthetic vascular grafts (sVG) are needed annually to address vascular diseases (a leading cause of death in humans) and kidney failure (as vascular access). However, in 70+ years since the first sVG in humans, we still do not have sVGs that fully endothelialize (the “holy grail” for truly successful grafts). The lack of healthy endothelium is believed to be a main cause for thrombosis, stenosis, and infection (the major reasons for graft failure). The immune-mediated foreign body response to traditional sVG materials encapsulates the materials in fibrotic scar suppressing vascularized healing. Here, we describe the first sVG optimized for vessel wall vascularization via uniform, spherical 40 μm pores. This sVG induced unprecedented rapid healing of luminal endothelium in a demanding and clinically relevant sheep model, probably by attracting and modulating macrophages and foreign body giant cells towards diverse, pro-healing phenotypes. Both this sVG and the control (PTFE grafts) remained 100 % patent during the implantation period. This advancement has broad implications beyond sVGs in tissue engineering and biocompatibility.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"320 ","pages":"Article 123206"},"PeriodicalIF":12.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiral nanoassembly remodels tumor microenvironment through non-oxygen-dependent depletion lactate for eﬀective photodynamic immunotherapy

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-21 DOI: 10.1016/j.biomaterials.2025.123203

Xuan Zhang , Jinwei Bai , Shihao Sun , Yu Li , Xinxin Li , Genping Meng , Wenyuan Cheng , Yuhui Yin , Zhiyi Wang , Baodui Wang

{"title":"Chiral nanoassembly remodels tumor microenvironment through non-oxygen-dependent depletion lactate for eﬀective photodynamic immunotherapy","authors":"Xuan Zhang , Jinwei Bai , Shihao Sun , Yu Li , Xinxin Li , Genping Meng , Wenyuan Cheng , Yuhui Yin , Zhiyi Wang , Baodui Wang","doi":"10.1016/j.biomaterials.2025.123203","DOIUrl":"10.1016/j.biomaterials.2025.123203","url":null,"abstract":"<div><div>Targeting lactate metabolism in tumor microenvironment (TME) has emerged as a promising strategy for enhancing immunotherapy. However, the commonly used strategy of lactate oxidation by lactate oxidase consumes oxygen, exacerbating tumor hypoxia and hindering immunotherapy. Here, we present a novel tumor-targeting, near infrared light-activated and TME-responsive chiral nanoassembly (Zn-UCMB) for enhancing photodynamic triggered immunogenic cell death (ICD) through a nonoxygen-dependent depletion of lactate. In the moderately acidic TME, the chiral Zn complex liberated from the Zn-UCMB selectively coordinates with <span>l</span>-lactate, leading to the depletion of lactate. Additionally, the Zn-UCMB facilitates the decomposition of H<sub>2</sub>O<sub>2</sub> into O<sub>2</sub>, which significantly enhances the efficacy of photodynamic therapy (PDT) and triggers a robust ICD effect. Moreover, the nonoxygen-dependent depletion of lactate can reprogram the TME by reducing the expression of HIF-1α, decreasing VEGF expression, and mitigating immunosuppressive conditions. This prompts the phenotypic transformation of tumor-associated macrophages from M2 to M1. Consequently, Zn-UCMB not only enhances the efficacy of PDT but also elicits a potent ICD during 980 nm laser irradiation, thereby effectively suppressing tumor growth and metastasis. The findings offer a novel approach to overcome the limitations of existing lactate metabolism-targeting strategies and provide a promising therapeutic option for enhancing the efficacy of immunotherapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"319 ","pages":"Article 123203"},"PeriodicalIF":12.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ‘Optimal electrical stimulation boosts stem cell therapy in nerve regeneration’ [Biomaterials 181 (2018) 18758]

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-21 DOI: 10.1016/j.biomaterials.2025.123172

Jian Du , Gehua Zhen , Huanwen Chen , Shuming Zhang , Liming Qing , Xiuli Yang , Gabsang Lee , Hai-Quan Mao , Xiaofeng Jia

引用次数: 0

Manganese-coordinated nanoparticles loaded with CHK1 inhibitor dually activate cGAS-STING pathway and enhance efficacy of immune checkpoint therapy

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-20 DOI: 10.1016/j.biomaterials.2025.123199

Rui Huang , Yijia Wu , Feiyang Shen , Shuai Chen , Xiaoyu Yang , Yao Lin , Yan Fang , Jianfeng Shen

{"title":"Manganese-coordinated nanoparticles loaded with CHK1 inhibitor dually activate cGAS-STING pathway and enhance efficacy of immune checkpoint therapy","authors":"Rui Huang , Yijia Wu , Feiyang Shen , Shuai Chen , Xiaoyu Yang , Yao Lin , Yan Fang , Jianfeng Shen","doi":"10.1016/j.biomaterials.2025.123199","DOIUrl":"10.1016/j.biomaterials.2025.123199","url":null,"abstract":"<div><div>Notable advancements have been made in utilizing immune checkpoint blockade (ICB) for the treatment of various cancers. However, the overall response rates and therapeutic effectiveness remain unsatisfactory. One cause is the inadequate immune environment characterized by poor T cell infiltration in tumors. To address these limitations, enhancing immune infiltration is crucial for optimizing the therapeutic efficacy of ICB. Activating the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is essential for initiating immune response and has become a potential target for developing combination therapies with ICB. In this study, we designed and fabricated manganese-containing nanoparticles loaded with the CHK1 inhibitor PF477736, which were subsequently encapsulated with macrophage membrane (PF/MMSN@MPM). This innovative design achieved excellent tumor targeting and demonstrated potent antitumor effects. The combination therapy dually amplified the cGAS-STING pathway, causing a cascade of enhanced therapeutic effects against tumors. Furthermore, single-cell mass cytometry (CyTOF) analysis revealed that PF/MMSN@MPM enhanced the activation and infiltration of immune cells. Moreover, the combination of PF/MMSN@MPM with anti-PD-1 (αPD-1) exhibited a stronger therapeutic effect compared to αPD-1 alone. PF/MMSN@MPM precisely and synergistically activated the cGAS-STING pathway, significantly improving therapeutic efficacy of ICB, and offering promising potential for tumor therapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"319 ","pages":"Article 123199"},"PeriodicalIF":12.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “An NIR-responsive hydrogel loaded with polydeoxyribonucleotide nano-vectors for enhanced chronic wound healing” [Biomaterials 314 (2025) 122789]

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-19 DOI: 10.1016/j.biomaterials.2025.123189

Yanzhen Sun , Yao Li , Xiaokang Ding , Pan Xu , Xiaodong Jing , Hailin Cong , Hao Hu , Bing Yu , Fu-Jian Xu

引用次数: 0

Structurally defined cartilaginous MEW-assembloids for critical-size long bone healing

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-19 DOI: 10.1016/j.biomaterials.2025.123202

Liuqi Peng , Amit Chandrakar , Gabriella Nilsson Hall , Konstantinos Ioannidis , Lorenzo Moroni , Paul Wieringa , Ioannis Papantoniou

{"title":"Structurally defined cartilaginous MEW-assembloids for critical-size long bone healing","authors":"Liuqi Peng , Amit Chandrakar , Gabriella Nilsson Hall , Konstantinos Ioannidis , Lorenzo Moroni , Paul Wieringa , Ioannis Papantoniou","doi":"10.1016/j.biomaterials.2025.123202","DOIUrl":"10.1016/j.biomaterials.2025.123202","url":null,"abstract":"<div><div>Bone defects exceeding a critical size pose significant clinical challenges due to their inability to heal spontaneously. Traditional treatments including autografts and synthetic implants, are often suffer from limitations such as donor site morbidity, infection risk, and poor integration. This study explores a novel approach using MEW-assembloid which combine Melt electrowriting (MEW) scaffolds with cartilaginous microtissues to enhance bone healing. Here, we fabricated bucket-shaped MEW scaffolds (OMesh and CMesh) to optimize microtissue retention and integration, with the OMesh design showing effective shape retention after microtissue seeding. To adapt the scaffold dimensions for <em>in vivo</em> implantation, we introduced elongated MEW (EMesh) based on the OMesh design, forming EMesh-assembloid. These constructs were evaluated for their ability to undergo endochondral ossification and mineralization in subcutaneous implants. Additionally, tubular MEW scaffolds were also created as stabilizers around EMesh-assembloid for orthotopic implantation and showed substantial new bone formation and nearly full defect bridging in a critical-sized mouse tibia defect model after 8 weeks. Our results indicates that MEW-assembloid offer a robust strategy for tissue engineering, enhancing the structural and functional integration of implants, and providing an innovation solution for the repair and regeneration of critical bone defects, potentially advancing clinical treatments for bone regeneration.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"319 ","pages":"Article 123202"},"PeriodicalIF":12.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tumor heterogeneity-independent antigen-responsive nanocarrier enabled by bioorthogonal pre-targeting and click-activated self-immolative polymer

IF 12.8 1区医学

Biomaterials Pub Date : 2025-02-19 DOI: 10.1016/j.biomaterials.2025.123200

Ye Liu , Qingyu Zong , Yalan Tu , Xingzu Zhang , Qiaoling Tan , Ihsan Ullah , Youyong Yuan

{"title":"A tumor heterogeneity-independent antigen-responsive nanocarrier enabled by bioorthogonal pre-targeting and click-activated self-immolative polymer","authors":"Ye Liu , Qingyu Zong , Yalan Tu , Xingzu Zhang , Qiaoling Tan , Ihsan Ullah , Youyong Yuan","doi":"10.1016/j.biomaterials.2025.123200","DOIUrl":"10.1016/j.biomaterials.2025.123200","url":null,"abstract":"<div><div>Bioorthogonal pre-targeting alleviate the limitations of traditional nanomedicines in passive and active targeting delivery. However, the high selectivity of bioorthogonal pre-targeting depends on the high expression level of antigens in lesion sites, and there are very limited targets with sufficient overexpression. Herein, we propose a tumor heterogeneity-independent antigen-responsive nanocarrier utilizing bioorthogonal pre-targeting and click-activated self-immolative polymers for stimulus signal conversion and amplification. This approach comprises a tetrazine (Tz) conjugated with trastuzumab (T-Tz), and a bioorthogonally activatable nanocarrier CONP which self-assembled by isocyanide and polyethylene glycol-modified poly (thiocarbamate) (NC-PTC-PEG) and hydrogen sulfide (H<sub>2</sub>S)-responsive self-immolative polymers. In practice, T-Tz is first injected to actively pretarget HER2-positive tumor cells and followed by the second injection of nanocarrier CONP. The NC-PTC-PEG in CONP undergoes a click reaction with Tz to generate H<sub>2</sub>S, thereby achieving the transformation from antigen signal to H<sub>2</sub>S signal. Finally, NO<sub>2</sub>-PTC-PEG responds to H<sub>2</sub>S stimulation and undergoes a head-to-tail depolymerization process similar to dominoes to produce a large amount of H<sub>2</sub>S, further amplifying the stimulus signal. This bioorthogonal pre-targeting combine with click-activated self-immolative polymers is anticipated to enhance the effectiveness of existing pre-targeting strategies for tumor imaging and therapy, with the potential to overcome challenges posed by tumor heterogeneity.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"319 ","pages":"Article 123200"},"PeriodicalIF":12.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0