Biomaterials最新文献

{"title":"Mimicking gingival endotoxin tolerance to modulate immune balance for tumor postoperative wound management","authors":"Daping Xie ,&nbsp;Zhencheng Liao ,&nbsp;Chonghao Chen ,&nbsp;Yuwei Li ,&nbsp;Zijun Zheng ,&nbsp;Yiming Niu ,&nbsp;Dandan Xia ,&nbsp;Yufeng Zheng ,&nbsp;Chunming Wang","doi":"10.1016/j.biomaterials.2025.123558","DOIUrl":"10.1016/j.biomaterials.2025.123558","url":null,"abstract":"<div><div>Postoperative management after tumor resection poses a significant clinical challenge as it must satisfy two demands – tumor eradication and tissue repair, which require contradictory immunological characteristics. Current treatment strategies have limitations as they usually fulfil one of the two requirements. Here, inspired by the unique mechanism of bacteria-triggered endotoxin tolerance (ET) in maintaining tissue homeostasis in the periodontal tissue, we devise a bioactive scaffold to establish an ET-mimicking immune niche in the local tissue of tumor resection. This glucomannan derivative-based electrospun scaffold (GMES) efficiently stimulates macrophages towards an ET state <em>via</em> a toll-like receptor-2 (TLR2)-dependent manner that, on the one hand, overexpresses pro-inflammatory factors and macrophage receptor with collagenous structure (MARCO) to suppress tumor recurrence and, on the other hand, release anti-inflammatory and pro-regenerative factors to promote wound healing. Our <em>in vivo</em> tests in three models of tumor recurrence, post-resection wounds and tumor metastasis show that GMES promotes healing at the tumor resection site while preventing tumor recurrence or metastasis. Our strategy represents a novel, microbial signal-inspired approach to postoperative tumor management.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123558"},"PeriodicalIF":12.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically engineering cells to produce therapeutically boosted extracellular vesicles for cardiovascular calcification","authors":"Neil Patel ,&nbsp;Veronica LaMastro ,&nbsp;Joshua Giblin ,&nbsp;Elijah Avery ,&nbsp;Bari Noor ,&nbsp;Gregory Magee ,&nbsp;Eun Ji Chung","doi":"10.1016/j.biomaterials.2025.123552","DOIUrl":"10.1016/j.biomaterials.2025.123552","url":null,"abstract":"<div><div>Calcification associated with atherosclerosis is a major driver of morbidity globally. Despite the correlation of calcification with plaque rupture and sudden death, there are no clinically approved therapies that treat vascular calcification. Notably, vascular smooth muscle cells (VSMCs) represent a promising target to inhibit vascular calcification, as VSMCs are the primary source of calcification deposition in the vasculature. To that end, we report a novel approach using extracellular vesicles (EVs) to deliver anti-osteogenic miR-133 to osteochondrogenic VSMCs in atherosclerosis. Traditionally, loading miRs into EVs is marred by low loading efficiency, inefficient EV modification, miR degradation, or loss of EV structural integrity. To address these challenges, VSMCs were transduced to create cell lines expressing miR-133 modified with ExoMotifs, or 4–8 nucleotide motifs which enable binding to proteins involved in miR sorting, resulting in VSMCs that secrete EVs highly loaded with miR-133. Additionally, EVs were surface functionalized with a hydroxyapatite binding peptide (HABP) to enable targeting to areas of vascular calcification. Our results show that HABP-miR-133-EVs can inhibit osteochondrogenic VSMCs, promote contractile VSMCs genes, and inhibit vascular calcification both <em>in vitro</em> and <em>in vivo</em> in murine atherosclerosis models. More broadly, we demonstrate a platform strategy to develop cellular factories for miR-loaded, therapeutic EVs that can be tailored for a variety of diseases.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123552"},"PeriodicalIF":12.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational contrast agents for use in fluorescence image-guided tumor surgery","authors":"Da-Yong Hou ,&nbsp;Xiang-Peng Li ,&nbsp;Yue-Ze Wang ,&nbsp;Peng Zhang ,&nbsp;Jiong-Cheng Wu ,&nbsp;Hui-Hui You ,&nbsp;Mei-Yu Lv ,&nbsp;Shi-An Zhou ,&nbsp;Xiao Liu ,&nbsp;Gao Zhang ,&nbsp;Hong-Wei An ,&nbsp;Hao Wang ,&nbsp;Wanhai Xu","doi":"10.1016/j.biomaterials.2025.123549","DOIUrl":"10.1016/j.biomaterials.2025.123549","url":null,"abstract":"<div><div>Currently, surgical intervention remains the foundation in curing most solid tumors. Over the past few decades, even with rapid intraoperative tissue pathology assessment, the overall rate of positive surgical margins for tumors stagnated between 15 % and 60 %. The increased local recurrence rates and poor prognoses associated with various cancers, such as head and neck, brain, breast, lung, prostate, and gastrointestinal cancers, are linked to positive margins. Recently, driven by the concept of precise surgery, significant advancements have been reported in the intraoperative use of fluorescent contrast agents in the field of surgery. Molecular imaging via intraoperative fluorescence plays a guiding role in surgery, providing surgeons with visible fluorescent images. In clinical applications, fluorescent contrast agents can clearly delineate tumor boundaries, offering high recognition capacities and real-time guidance during surgery. Additionally, they can localize lymph node metastases, detect small metastatic lesions, and identify critical anatomical structures during surgery, thus reducing the risk of collateral damage. An ideal surgical guidance technology should lack radiation and display a high sensitivity and good resolution and an adjustable field of view, with rapid imaging. Enhancing the tissue penetration of fluorescence and targeting capacities of molecular probes are critical in providing more comprehensive tumor-related data. Additionally, screening and identifying other tumor biomarkers and more of their corresponding targeted molecular data are essential in enhancing the specificity of molecular imaging. Finally, the investigation and use of a wider range of near-infrared fluorescent dyes with improved biocompatibilities and imaging are critical in designing synthetic probes for application in intraoperative navigation. The development of novel, efficient, safe fluorescent contrast agents is a critical direction in current pharmaceutical research and development.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123549"},"PeriodicalIF":12.8,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contactless 3D acoustic assembly of liquid capsules for bottom-up tissue engineering","authors":"Maria Eduarda Rocha Luiz ,&nbsp;Mariana Carreira ,&nbsp;Sara Nadine ,&nbsp;Riccardo Tognato ,&nbsp;Romedi Parolini ,&nbsp;Syeda M. Bakht ,&nbsp;Tiziano Serra ,&nbsp;João F. Mano","doi":"10.1016/j.biomaterials.2025.123555","DOIUrl":"10.1016/j.biomaterials.2025.123555","url":null,"abstract":"<div><div>In recent years, considerable efforts have been directed towards developing systems that replicate native tissue microarchitecture, enhancing cell viability and achieving close-to-native cellular organization. Despite advancements in various assembly methods, scalability and cell viability remain challenging due to the time consuming nature of certain approaches. Acoustic assembly has emerged as a powerful technology for modular units' assembly, leveraging sound waves to achieve rapid, contactless spatial arrangement by fine-tuning parameters such as frequency, amplitude, and chamber geometry. Here we present a system that employs acoustic waves to generate spatial patterns of liquid-core microcapsules, encapsulating poly-caprolactone surface-functionalized microparticles and umbilical cord-derived mesenchymal stem cells. The microcapsules were produced using electrohydrodynamic atomization in conjugation with an aqueous two-phase system and subsequently embedded in gelatin methacrylate. Acoustic waves were then applied to assemble the liquid-core microcapsules in well-defined patterns within the hydrogel precursor followed by crosslinking for structural stability. This approach allows us to define spatial patterns with precision, aligning with simulation predictions. The liquid nature of the microcapsules’ core permits the organization of cells within the space towards the formation of microtissues decoupled from the external environment. The patterned constructs maintained cell viability for 14 days, facilitating the formation of microaggregates within liquid-core microcapsules and maintained organized microstructures. To explore the versatility of this system, we successfully patterned and stacked multiple layers of microcapsules, increasing structural complexity. Furthermore, we demonstrated its ability to support co-culture by seeding human umbilical vein endothelial cells onto the constructs as a proof of concept for promoting enhanced cellular interactions. This platform offers a scalable, versatile solution for developing tissue-mimetic multiscale constructs with tunable complexity, enabling rapid and non-contact assembly, making it a valuable tool for advancing in vitro models and studying complex cellular interactions.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123555"},"PeriodicalIF":12.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetically controlled microgelbots with stem cells for the treatment of interstitial cystitis","authors":"Hyunsik Choi ,&nbsp;Bolam Kim ,&nbsp;Yewon Seo ,&nbsp;Tae Yeon Kim ,&nbsp;Ki Wan Bong ,&nbsp;Sei Kwang Hahn","doi":"10.1016/j.biomaterials.2025.123551","DOIUrl":"10.1016/j.biomaterials.2025.123551","url":null,"abstract":"<div><div>Stem cell therapy has been widely investigated for the treatment of chronic bladder diseases such as interstitial cystitis/bladder pain syndrome (IC/BPS). However, the delivery of stem cells into the bladder wall is limited due to the mucus layer lining the bladder wall and the frequent urination, leading to the fast clearance of stem cells from the bladder. Here, we report a soft microgelbot (μgelbot) composed of a magnetic nanochain embedded microgel in a tunable size and shape for the enhanced delivery of mesenchymal stem cells (MSCs) into the bladder wall through the mucus layer. <em>In vitro</em> penetration tests to optimize the shape of μgelbots show that the quadrangle shaped μgelbots effectively apply a shear force to the surrounding shear-thinning mucus layer for the enhanced penetration under a rotating magnetic field. After loading MSCs onto the μgelbot, we confirm the enhanced penetration and retention in the reconstructed mucus layer. Finally, we successfully demonstrate the paracrine effects of MSCs loaded μgelbots on chronic IC murine models, inhibiting the mast cell infiltration, collagen deposition, and bladder cell apoptosis. Taken together, we could confirm the feasibility of magnetically controlled μgelbots as a promising platform for the stem cell therapy of IC/BPS.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123551"},"PeriodicalIF":12.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenascin-c functionalised self-assembling peptide hydrogels for critical-sized bone defect reconstruction","authors":"Alexandre Trubert-Paneli ,&nbsp;Jonathan A. Williams ,&nbsp;James F.C. Windmill ,&nbsp;Leire Iturriaga ,&nbsp;Eonan W. Pringle ,&nbsp;Theodora Rogkoti ,&nbsp;Siyuan Dong ,&nbsp;Amaia Cipitria ,&nbsp;Aline F. Miller ,&nbsp;Cristina Gonzalez-Garcia ,&nbsp;Alberto Saiani ,&nbsp;Manuel Salmeron-Sanchez","doi":"10.1016/j.biomaterials.2025.123553","DOIUrl":"10.1016/j.biomaterials.2025.123553","url":null,"abstract":"<div><div>Critical-sized bone defects cannot heal spontaneously and receive poor clinical prognosis due to limitations in modern treatment strategies. Next-generation therapies are applying biomaterials incorporating BMP-2 to effectively promote and support bone regeneration, but adverse effects are linked to uncontrolled BMP-2 egress from the biomaterial. Implementing extracellular matrix proteins to biomaterials is a favourable approach to alleviate these drawbacks, and self-assembling peptide hydrogels are rapidly emerging as modulable and versatile biomaterials. Here, we describe the creation of a tenascin-<em>c</em>-functionalised peptide hydrogel designed to regenerate critical-sized bone defects. A recombinant fragment of tenascin-c spanning from the 3^rd to 5^th fibronectin-like domains is integrated into the fibre network. We demonstrate that this nascent construct effectively retains BMP-2 to differentiate mesenchymal stem cells into mature osteoblasts and achieves complete unionisation of murine critical-sized bone defects under low BMP-2 dose. All in all, we demonstrate tenascin-c as a suitable candidate to functionalise biomaterials intended for bone engineering applications and the promising potential of self-assembling peptide hydrogels in treating critical-sized bone defects.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123553"},"PeriodicalIF":12.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-facilitated peroxidase-like hydrogel with simultaneous wound infection monitoring and eliminating","authors":"Zhibin Li ,&nbsp;Guangtao Huang ,&nbsp;Xiangqiang Dai ,&nbsp;Mulan Qahar ,&nbsp;Zi Ye ,&nbsp;Minghui Wang ,&nbsp;Jiawen Deng ,&nbsp;Xiaoqi Zhang ,&nbsp;Yan Zhou ,&nbsp;Yu He ,&nbsp;Shi Chen ,&nbsp;Jun Wu","doi":"10.1016/j.biomaterials.2025.123542","DOIUrl":"10.1016/j.biomaterials.2025.123542","url":null,"abstract":"<div><div>Clinically, despite tremendous efforts having been devoted to preventing the invasive bacterial infection in acute and chronic wounds, the abuse or excessive use of antibacterial agents still poses great hurdles for wound management, which significantly raises the risk of detrimental side-effects and complications in the wound disinfection. Herein, we develop a hydrogel dressing of MPAH to attain real-time infection monitoring and on-demand antibacterial therapy. In this scenario, we propose a creative strategy of applying laser-facilitated MPAH photodecomposition of H₂O₂ to trigger the burst release of reactive oxygen species (ROS) and thus eliminate bacteria. Taking advantage of the visible indication of pH variability and laser-mediated ROS burst release, MPAH permits real-time monitoring of wound infection status and simultaneously endows it with superior on-demand antibacterial activity at a low H₂O₂ dosage. Beyond that, MPAH also provides a favorable healing environment synergistically promotes wound closure and re-epithelialization. With these merits, MPAH presents a vast potential for wound disinfection and simultaneously addresses the histotoxicity issues of routinely used medical H₂O₂ (3 %, V/V). Therefore, our study not only pioneers the exploration of a promising alternative antibacterial strategy, but more excitingly, also opens a profound vista for potential biomedical applications of laser-facilitated H₂O₂ photodecomposition.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123542"},"PeriodicalIF":12.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable natural Tremella-derived hydrogel for reversing ferroptosis-mediated osteoporotic microenvironment imbalance and promoting osteoregeneration","authors":"Cong Ye ,&nbsp;Jiabao Xu ,&nbsp;Lei Shi ,&nbsp;Chaoyang Zong,&nbsp;Wei Ji,&nbsp;Yue Lu,&nbsp;Ran Tao,&nbsp;Fei Han,&nbsp;Hongdong Ma","doi":"10.1016/j.biomaterials.2025.123532","DOIUrl":"10.1016/j.biomaterials.2025.123532","url":null,"abstract":"<div><div>Osteoporotic bone defects constitute a global health predicament due to their restricted self-repairing capacity. Ferroptosis arising from iron overload represents a crucial pathological characteristic of osteoporosis, depleting osteoblasts and disturbing bone metabolism. Inspired by natural tremella polysaccharide (TP), we developed an injectable composite hydrogel (OGP@DTrep) capable of inhibiting cell ferroptosis via dual mechanisms. Following the incorporation of methacrylated TP, oxidized TP, thioketal (TK), and osteogenic growth peptide (OGP), OGP@DTrep exhibits a range of biological activities including intelligent reactive oxygen species (ROS) response and drug release, immunomodulation, promotion of angiogenesis, and inhibition of osteoclast activity. More importantly, since the carboxyl group in TP and the hydroxyl group of the sugar unit can form salt bridge interactions and hydrogen bond linkages with free iron ions, respectively, OGP@DTrep can efficiently chelate excessive iron ions in the microenvironment. Moreover, OGP@DTrep increases the intracellular antioxidant capacity, inhibits osteoblast ferroptosis, and enhances bone matrix secretion. In a rat model of osteoporotic bone defects, it reversed iron metabolism imbalance, restoring bone mass and microstructure. This study presents a naturally derived biomaterial with multiple activities, such as a ROS response and iron metabolism regulation, offering a new perspective for treating osteoporotic bone defects and other bone diseases.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123532"},"PeriodicalIF":12.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in exosome-based nanodelivery systems for Parkinson's disease","authors":"Yongqiang Zhu ,&nbsp;Qi Xi ,&nbsp;Yan Liu ,&nbsp;Yang Zhou ,&nbsp;Jun Liao ,&nbsp;Qiong Wu","doi":"10.1016/j.biomaterials.2025.123548","DOIUrl":"10.1016/j.biomaterials.2025.123548","url":null,"abstract":"<div><div>Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects dopaminergic neurons in the substantia nigra. Its multifactorial pathogenic mechanisms include oxidative stress, mitochondrial dysfunction, α-synuclein aggregation, neuroinflammation, and alterations in the gut microbiome, ultimately leading to neuronal deficits and debilitating motor and nonmotor symptoms. Although conventional therapies provide temporary relief, their efficacy tends to wane over time or produce adverse effects. Exosome-based therapeutic strategies are a promising alternative, and we highlight the unique advantages of exosomes, including their biocompatibility, low immunogenicity, and ability to cross the blood-brain barrier, thereby facilitating the targeted delivery of neuroprotective and anti-inflammatory medications to affected regions. We also discuss recent advances in exosome engineering to improve cargo loading, enhance cell specificity and improve efficacy. However, large-scale exosome production, targeted delivery and long-term safety remain major challenges. Early-phase clinical trials of exosome-based therapies in other neurodegenerative conditions have demonstrated acceptable tolerability, and ongoing preclinical studies in PD models suggest potential efficacy, laying the groundwork for future clinical translation.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123548"},"PeriodicalIF":12.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generation of patient-derived sarcoma organoids for personalized drug screening and precision cancer immunotherapy","authors":"Haixia Ma ,&nbsp;Xiaoyang Li ,&nbsp;Jinxi Li ,&nbsp;Jie Bu ,&nbsp;Xianan Li ,&nbsp;Jie Zhang ,&nbsp;Shengji Yu ,&nbsp;Guangjun Nie ,&nbsp;Hai Wang ,&nbsp;Helin Feng","doi":"10.1016/j.biomaterials.2025.123546","DOIUrl":"10.1016/j.biomaterials.2025.123546","url":null,"abstract":"<div><div>Sarcomas are malignant tumors that display inter- and intra-tumoral heterogeneity. Patient-derived organoids enable the creation of systems that stably recapitulate many aspects of parental tumors <em>in vitro</em>. Thus, the idea of using patient-derived organoids for therapeutic screening and precision medicine is tantalizing. Here, we describe a biobank of soft tissue and bone sarcoma (STBS) organoid lines derived from patient tumor tissues. In total, we established 44 STBS organoid lines, representing eight subtypes of STBS. These STBS organoids faithfully recapitulate the histological features, mutational profiles, gene expression profiles, and cellular diversity of the corresponding tumors. STBS organoids can be used not only for screening chemotherapeutic and target therapeutic drugs, but also for predicting immune responses. Our data demonstrate the potential of STBS organoids for both basic research and for designing personalized sarcoma treatments.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123546"},"PeriodicalIF":12.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}