Biomaterials最新文献

{"title":"Iron oxide nanoparticles-driven mitochondrial renewal rejuvenates the aged bone marrow niche","authors":"Xiaoqing Sun ,&nbsp;Xingyou Wang ,&nbsp;Meihua Zhang ,&nbsp;Shuyao Liu ,&nbsp;Yue Zhu ,&nbsp;Jing He ,&nbsp;Yao Wu","doi":"10.1016/j.biomaterials.2026.123989","DOIUrl":"10.1016/j.biomaterials.2026.123989","url":null,"abstract":"<div><div>With the aging population, treating age-related osteoporosis remains challenging due to the dysfunctional bone marrow microenvironment characterized by chronic inflammation, metabolic dysregulation, and impaired mitochondrial function in senescent cells. While mitochondrial transfer from macrophages to bone marrow mesenchymal stem cells (BMSCs) offers a promising therapeutic avenue, its efficacy is limited in aged niches where donor mitochondria exhibit functional deficits and poor recipient compatibility. We engineered KGM-PEG-SPIONs, functionalized Fe₃O₄ nanoparticles that enhance donor mitochondrial quality via autophagy activation and Fe–S cluster biogenesis, promote M2 macrophage polarization, and improve compatibility with the oxidative and inflammatory environment of senescent BMSCs. These M2-like mitochondria are transferred through connexin 43 gap junctions, restoring membrane potential, ATP production, calcium homeostasis, and osteogenic differentiation in recipient cells. In aged osteoporotic models, KGM-PEG-SPION-functionalized scaffolds remodel immune niches and promote bone formation. By integrating organelle quality control with environment-adapted mitochondrial transfer, this strategy surpasses approaches focusing solely on transfer quantity or polarization, establishing a programmable nanoplatform for organelle-based regeneration.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 123989"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145957408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recapitulating tumor extracellular matrix alignment to decipher its role in eliciting malignant cell phenotypes using a peptide liquid crystal hydrogel","authors":"Si-Yong Qin ,&nbsp;Wei-Wei Cheng ,&nbsp;Meng-Yun Peng ,&nbsp;Chuang Cai ,&nbsp;Qi Lei ,&nbsp;Rong Huang ,&nbsp;Yin-Jia Cheng ,&nbsp;Wen-Long Liu ,&nbsp;Yi-Han Ma ,&nbsp;Ai-Qing Zhang ,&nbsp;Lei Wang","doi":"10.1016/j.biomaterials.2026.124017","DOIUrl":"10.1016/j.biomaterials.2026.124017","url":null,"abstract":"<div><div>The aligned microarchitecture of extracellular matrix (ECM) has been recognized as a significant and novel hallmark of certain tumors, which is gradually uncovered to relate to their malignant progression. However, most artificial scaffolds are isotropic and fail to mimic such aligned organization of tumor-associated ECMs. To address this limitation, we developed a self-assembling peptide-based liquid crystal (LC) hydrogel model to recapitulate the aligned topology of tumor ECM, thereby establishing a platform to investigate the relationship between ECM alignment and malignant cell phenotype. The screened peptide self-assembled into aligned nanofibers via a thermal pathway, forming an LC hydrogel with engineered biological properties. When cultured within the peptide LC hydrogel, tumor cells displayed enhanced proliferation, migration, invasion, and drug-resistance, underscoring the critical role of ECM alignment in promoting aggressive phenotypes. Leveraging the LC hydrogel model, we provided initial insights into the mechanisms underlying malignant progression via Western blot, reverse transcription-quantitative PCR and RNA sequencing analyses. Moreover, by implanting LC hydrogel precultured cancer cells into C57BL/6 mice, we established a tumor model exhibiting accelerated growth. Our findings demonstrate that the self-assembled peptide LC hydrogel can recapitulate tumor ECM alignment and enable the development of rapidly progressing tumor models for cancer research and drug screening.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 124017"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor disaggregation sensitizes radio-therapy for low rectal tumor","authors":"Hanyong Dong ,&nbsp;Yuedong Guo ,&nbsp;Jianlin Shi ,&nbsp;Ping Hu","doi":"10.1016/j.biomaterials.2026.124029","DOIUrl":"10.1016/j.biomaterials.2026.124029","url":null,"abstract":"<div><div>Hypoxia within solid tumors has been identified as one of the main obstacles in radiotherapy due to the severely reduced radiosensitivity. Current strategies to alleviate tumor hypoxia mainly rely on oxygen supplementation using oxygen carriers (e.g., hemoglobin- or perfluorocarbon-based systems), hypoxia-activated prodrugs, or tumor oxygen consumption modulators, leading to limited efficacies due to poor tumor-specific targeting, insufficient oxygen delivery in the complex tumor microenvironment, and potential systemic toxicity. Here we propose an alternative but novel strategy for radiosensitization in colorectal cancer radiotherapy by uncompacting the tumor tissue via tumor disaggregation, thus alleviating tumor hypoxia and enhancing radiosensitivity. This strategy has been realized by developing a nanomedicine composed of ethylene diamine tetraacetic acid-loaded layered double hydroxide (LDH/EDTA) featuring intratumoral acidity-responsive EDTA release. The released EDTA deprives Ca²⁺ ions from the intercellular cadherins that connect tumor cells through EDTA- Ca²⁺ chelation, thus disrupting the inter-cellular junctions in tumor tissue by cadherin damages. As a result, compactness and rigidity of tumor tissues are greatly reduced, and the ambient oxygen is allowed to diffuse deep into the tumor interior, thereby alleviating the hypoxia of solid tumors and effectively enhancing their sensitivity to radiotherapy. This work proposes a novel yet facile strategy to enhance radiosensitivity simply by overcoming the physical barriers of tumors and alleviating hypoxia.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 124029"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D culture reveals dual role of ICAM-1 in mediating tissue-specific human MSC spheroid formation & enhanced immunomodulation","authors":"Li-Tzu Wang ,&nbsp;Hsiu-Huan Wang ,&nbsp;Duong Thi Thuy Doan ,&nbsp;Yun-Fei Lin ,&nbsp;Chien-Yu Liao ,&nbsp;Pei-Ju Hsu ,&nbsp;Chia-Chih Chang ,&nbsp;Men-Luh Yen ,&nbsp;Ko-Jiunn Liu ,&nbsp;Huey-Kang Sytwu ,&nbsp;B. Linju Yen","doi":"10.1016/j.biomaterials.2026.123998","DOIUrl":"10.1016/j.biomaterials.2026.123998","url":null,"abstract":"<div><div>Three-dimensional (3D) <em>in vitro</em> culture systems may better mimic <em>in vivo</em> physiological conditions, and are easily accessible methods to improve therapeutic effectiveness of human mesenchymal stem cells (MSCs), which with its many sources appear to harbor clinically relevant functional differences. We therefore investigated the impact and elucidated the mechanism(s) of 3D culture on the immunomodulatory capacity of two commonly used MSC sources, bone marrow (BM) and placental (P). In 3D conditions, PMSCs (PMSC 3D) form larger spheroids than BMMSCs (BMMSC 3D), with whole transcriptome profiling revealing significant enrichment of cell adhesion and immunomodulatory pathways. qPCR and functional validation demonstrated the highest expression of numerous key immunomodulatory factors and strongest capacity to inhibit T cell proliferation with PMSC 3D. Bioinformatics analyses predicted Intercellular Adhesion Molecule 1 (ICAM-1) as crucial for both PMSC 3D spheroid formation and enhanced immunomodulatory capacity, which was validated with flow cytometric analyses and further delineated with single-cell RNA sequencing data. To assess mechanistic involvement, we performed knockdown of ICAM-1 which significantly reduced PMSC 3D spheroid size as well as both <em>in vitro</em> and <em>in vivo</em> immunomodulatory capacity. These findings demonstrate that 3D culture significantly enhances the immunomodulatory potential of PMSCs, and reveal ICAM-1 as having a dual role in spheroid formation as well as modulation of immune responses. Our study also highlights the importance of understanding source-specific differences as well as the profound influence of 3D <em>in vitro</em> systems on MSC functions.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 123998"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145957407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic cascade “four-in-one” Nanozyme for remodeling the redox tumor microenvironment and disrupting energy homeostasis to enhance ferroptosis against triple-negative breast cancer","authors":"Lei Li ,&nbsp;Annan Liu ,&nbsp;Ze Wang ,&nbsp;Hao Liang ,&nbsp;Andrew K. Whittake ,&nbsp;Hui Guo ,&nbsp;Quan Lin","doi":"10.1016/j.biomaterials.2026.124001","DOIUrl":"10.1016/j.biomaterials.2026.124001","url":null,"abstract":"<div><div>Ferroptosis, a promising therapeutic strategy for triple-negative breast cancer (TNBC), faces significant challenges due to intrinsic tumor defense mechanisms. To enhance ferroptosis against TNBC, a biomimetic “four-in-one' cascade nanozyme AuPd/Cu₂O@Cancer cell membrane (APCM) was engineered to remodel tumoral redox microenvironment and disrupt cancer cell energy metabolism. APCM nanozyme integrates four enzyme-mimicking activities into a single nanoplatform, including peroxidase-like, glucose oxidase-like, catalase-like, and glutathione peroxidase-like. This synergistic cascade converts endogenous H₂O₂ to cytotoxic ·OH, depletes glucose to block energy supply while self-supplying H₂O₂, alleviates hypoxia, and depletes glutathione to suppress antioxidant defense, collectively triggering lethal reactive oxygen species (ROS) accumulation for ferroptosis. APCM further enables photothermal therapy (PTT), inducing direct thermal ablation and providing localized heat to augment nanocatalytic efficacy. Coating with tumor-derived membrane facilitates homologous targeting and immune evasion. Transcriptomic analysis confirmed profound APCM-mediated modulation of ferroptosis, metabolic, and redox-associated gene signatures. Notably, the APCM nanozyme enables dual-mode imaging, offering visualization of the location of TNBC and precise guidance for treatment. Collectively, this “four-in-one' biomimetic nanozyme, which integrates multiple enzyme-mimicking activities and tumor-cell-membrane camouflage, effectively disrupts redox and metabolic homeostasis to potentiate ferroptosis, establishing a promising therapeutic paradigm for TNBC.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 124001"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonging the anti-tumor effects of cold atmospheric plasma via exosome-mediated signaling","authors":"Wen Li ,&nbsp;Li Cao ,&nbsp;Jiaqi Zhu ,&nbsp;Hui Wang ,&nbsp;Yijie Liu ,&nbsp;Lingyu Zhang ,&nbsp;Chen Guo ,&nbsp;Jing Yan ,&nbsp;Wenjing Wang ,&nbsp;Bo Zhou ,&nbsp;Jiangfang Lian ,&nbsp;Bo Guo ,&nbsp;Chen Huang","doi":"10.1016/j.biomaterials.2026.124011","DOIUrl":"10.1016/j.biomaterials.2026.124011","url":null,"abstract":"<div><div>Cold atmospheric plasma (CAP) has emerged as a promising non-thermal modality in cancer research due to its ability to induce selective cytotoxicity through reactive oxygen and nitrogen species. However, the limited penetration depth and instability of plasma-derived reactive species in complex biological environments remain major obstacles to its therapeutic application. In this study, we investigated whether exosomes derived from CAP-treated cancer cells (CAP-Exo) could serve as functional mediators to extend and amplify the anti-tumor effects of CAP. Using chronic myeloid leukemia K562 cells as a primary model, we demonstrate that CAP treatment induces pronounced oxidative stress, apoptosis, and sustained proliferative suppression. Importantly, exosomes isolated from CAP-treated cells exhibited enhanced anti-proliferative and pro-apoptotic activity in recipient cells compared to exosomes from untreated controls. To assess the broader applicability of this strategy, we further evaluated the effects of CAP and CAP-Exo in multiple solid tumor models, including breast, renal, and hepatocellular carcinoma cells, both <em>in vitro</em> and <em>in vivo</em>. CAP exposure consistently reduced cell viability across solid tumor cell lines, while CAP-Exo retained potent cytotoxic activity against breast cancer cells and significantly suppressed tumor growth in corresponding xenograft models without inducing systemic toxicity. Mechanistically, CAP-induced stress reprogrammed exosomal cargo, enabling the transfer of death-associated molecular signals to recipient tumor cells and thereby promoting apoptosis. Collectively, our findings indicate that CAP-modified exosomes represent a biologically active, cell-free approach that extends the anti-tumor effects of CAP treatment across both hematological malignancies and solid tumors. Rather than replacing existing therapeutic modalities, CAP-Exo may serve as a complementary strategy to enhance CAP-based cancer interventions and overcome current limitations associated with direct CAP application.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 124011"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146045957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant-free biopolymer particles mimicking the Chikungunya virus surface induce protective immunity","authors":"Nivethika Sivakumaran ,&nbsp;Joseph Freitas ,&nbsp;Shuxiong Chen ,&nbsp;Alfred K. Lam ,&nbsp;Lucas J. Adams ,&nbsp;Michael S. Diamond ,&nbsp;Suresh Mahalingam ,&nbsp;Bernd H.A. Rehm","doi":"10.1016/j.biomaterials.2026.124000","DOIUrl":"10.1016/j.biomaterials.2026.124000","url":null,"abstract":"<div><div>Chikungunya virus, a mosquito-borne alphavirus, causes outbreaks of both acute and chronic musculoskeletal diseases. Despite the recent approval of a live-attenuated and virus-like particle-based vaccine, a stable, safe and efficacious vaccine that can be manufactured at low cost is lacking. To address this need, we engineered <em>Escherichia coli</em> to produce robust biopolymer particles (BPs) densely coated with CHIKV envelope glycoproteins E2 and E1, forming a natively folded heterodimer mimicking the virus surface (E2-BP-E1). Native E2-E1 heterodimer formation was confirmed by monoclonal antibodies binding to five neutralizing epitopes and by binding of the receptor Mxra8. The structural model of BP-tethered E2-E1 aligned with the crystal structure of mature E2-E1 complex. <em>In vitro</em>, E2-BP-E1 activated dendritic cells (DCs) to produce Th1 cytokines, present MHC class I/II T cell epitopes, and stimulate CD4⁺ and CD8⁺ T cell proliferation. <em>In vivo</em>, vaccination without adjuvant induced potent neutralizing antibodies and protective immunity, with a ∼5 log₁₀ reduction in viremia. Histological analysis of muscle and joints confirmed reduced inflammation and pathology in vaccinated mice. E2-BP-E1 was produced using standard <em>E. coli</em> fermentation suggesting safe, cost-effective and scalable manufacturability offering advantages over current vaccines. Overall, we developed a stable particulate CHIKV vaccine that is safe and efficiently protects against infection without the need of an adjuvant.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 124000"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart multifunctional ROS-responsive supramolecular hydrogel for simultaneously regulating oxidative stress, immune dysregulation, and bacterial infection in diabetic wound healing","authors":"Xuehao Tian ,&nbsp;Yuting Wen ,&nbsp;Zhongxing Zhang ,&nbsp;Ke Zhou ,&nbsp;Lu Shang ,&nbsp;Jingling Zhu ,&nbsp;Xia Song ,&nbsp;Jun Li","doi":"10.1016/j.biomaterials.2026.124006","DOIUrl":"10.1016/j.biomaterials.2026.124006","url":null,"abstract":"<div><div>Diabetic wounds present a significant clinical challenge due to prolonged inflammation and impaired healing associated with excessive reactive oxygen species (ROS) and macrophage dysfunction. In this study, we developed a smart multifunctional ROS-responsive supramolecular hydrogel composed of carboxymethyl chitosan (CMCS) that is dynamically crosslinked by inclusion complexes of β-cyclodextrin (βCD) and ferrocene (Fc). This hydrogel facilitates the on-demand release of interleukin-4 (IL-4) while exhibiting intrinsic antibacterial properties. The IL-4-loaded hydrogel (IL-4@Gel-CD/Fc) responds to elevated H₂O₂ levels, destabilizing βCD/Fc crosslinking through the Fenton reaction, which simultaneously promotes ROS scavenging and accelerates IL-4 release. The system subsequently reprograms macrophages from the proinflammatory M1 phenotype to the anti‒inflammatory M2 phenotype, thereby addressing immune dysregulation in diabetic wounds. In vitro evaluations demonstrated significant reductions in ROS levels, effective M2 macrophage polarization, and antibacterial activity. In vivo studies using a diabetic rat model revealed that, compared to controls, IL-4@Gel-CD/Fc significantly enhanced wound closure, collagen density, and angiogenesis while reducing proinflammatory cytokines (IL-6 and TNF-α) and increasing anti‒inflammatory cytokine IL-10 levels. Overall, this smart hydrogel system offers a novel strategy to simultaneously regulate oxidative stress, immune dysregulation, and bacterial infection, thereby promoting effective wound healing in diabetic conditions.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 124006"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Comprehensive multi-omics of age-respective plasma and matrix-bound extracellular vesicles identifies anti-fibrotic miRNAs validated on a heart-on-a-chip”","authors":"George Ronan ,&nbsp;Lauren Hawthorne ,&nbsp;Jun Yang ,&nbsp;Ruyu Zhou ,&nbsp;Frank Ketchum ,&nbsp;Nicole Kowalczyk ,&nbsp;Fang Liu ,&nbsp;Pinar Zorlutuna","doi":"10.1016/j.biomaterials.2026.124031","DOIUrl":"10.1016/j.biomaterials.2026.124031","url":null,"abstract":"<div><div>Aging is a major risk factor for cardiovascular disease, the leading cause of death worldwide, and numerous other diseases, but the mechanisms of these aging-related effects remain elusive. Recent evidence suggests that chronic changes in the microenvironment and local paracrine signaling are major drivers of these effects, but the precise effect of aging on these factors remains understudied. Here, for the first time, we directly compare extracellular vesicles obtained from young and aged patients to identify therapeutic or disease-associated agents, and directly compare vesicles isolated from heart tissue matrix (TEVs) or plasma (PEVs). While young TEVs and PEVs showed notable overlap of miRNA cargo, aged EVs differed substantially, indicating differential aging-related changes between TEVs and PEVs. TEVs overall were uniquely enriched in miRNAs which directly or indirectly demonstrate cardioprotective effects, with 45 potential therapeutic agents identified in our analysis. Both populations also showed increased predisposition to disease with aging, though through different mechanisms. Changes in PEV cargo were largely correlated with chronic systemic inflammation, while those in TEVs were more related to cardiac homeostasis and local inflammation. From this, 17 protein targets were identified which were unique to TEVs and highly correlated with aging and the onset of cardiovascular disease. Further analysis via machine learning techniques implicated several new miRNA and protein targets, independently suggesting several of the targets identified by non-machine learning analysis, which correlated with aging-related changes in TEVs. With further study, this biomarker set may serve as a powerful, potential indicator of cardiac health and age which can be measured from PEVs. Additionally, several proposed “young-enriched” therapeutic agents were validated and, when tested, could successfully prevent cell death and cardiac fibrosis in disease-like conditions using a microfluidic heart-on-a-chip to model of acute and chronic fibrosis, making this study the first in literature to test the efficacy of a miRNA-based therapeutic encapsulated in lipid nanoparticles in an organ-on-a-chip device.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 124031"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biomietic filamentous hydrogel with enhanced bacteria contact and bactericidal efficiency for the treatment of various skin infections","authors":"Yongchang Tian ,&nbsp;Rong Zhang ,&nbsp;Xingjun Zhao ,&nbsp;Ian W. Hamley ,&nbsp;Chunsheng Xiao ,&nbsp;Li Chen","doi":"10.1016/j.biomaterials.2025.123968","DOIUrl":"10.1016/j.biomaterials.2025.123968","url":null,"abstract":"<div><div>Antimicrobial hydrogels that can effectively eliminate microorganisms to accelerate wound healing have demostrated great potential in managing wound infections. However, conventional hydrogel dressings have limited contact with bacteria due to their permemnent cross-linked structure, thereby reducing their bactericidal efficiency. To address this issue, we designed and prepared a neutrophil extracellular traps (NETs) biomimetic antibacterial hydrogel (PETP gel) with enhanced bacteria contact and bactericidal efficiency through Schiff base crosslinking of antibacterial polymer PETP-NH₂ and phenylboronic acid functionalized oxidized hyaluronic acid (OHA-PBA). The obtained PETP gel exhibited a NETs-mimicking dynamic filamentous network structure, which, in combination with the interaction between phenylboronic acid in OHA-PBA and lipopolysaccharides in bacterial surface, ultimately led to enhanced bacteria contact and bactericidal efficiency. <em>In vivo</em> experiments showed that PETP gel could accelerate healing in treatment of purulent subcutaneous infection, full-thickness wound infection, and deep second-degree burn infection, showing promising use as an antibacterial care dressing.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"330 ","pages":"Article 123968"},"PeriodicalIF":12.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}