Biomaterials最新文献_第3页

Mitochondria-targeting materials and therapies for regenerative engineering.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123023

Hongying Fu, Jingrong Cheng, Le Hu, Boon Chin Heng, Xuehui Zhang, Xuliang Deng, Yang Liu

{"title":"Mitochondria-targeting materials and therapies for regenerative engineering.","authors":"Hongying Fu, Jingrong Cheng, Le Hu, Boon Chin Heng, Xuehui Zhang, Xuliang Deng, Yang Liu","doi":"10.1016/j.biomaterials.2024.123023","DOIUrl":"10.1016/j.biomaterials.2024.123023","url":null,"abstract":"The hemostatic, inflammatory, proliferative, and remodeling phases of healing require precise spatiotemporal coordination and orchestration of numerous biological processes. As the primary energy generators in the cell, mitochondria play multifunctional roles in regulating metabolism, stress reactions, immunity, and cell density during the process of tissue regeneration. Mitochondrial dynamics involves numerous crucial processes, fusion, fission, autophagy, and translocation, which are all necessary for preserving mitochondrial function, distributing energy throughout cells, and facilitating cellular signaling. Tissue regeneration is specifically associated with mitochondrial dynamics due to perturbations of Ca2+, H2O2 and ROS levels, which can result in mitochondrial malfunction. Increasing evidence from multiple models suggests that clinical interventions or medicinal drugs targeting mitochondrial dynamics could be a promising approach. This review highlights significant advances in the understanding of mitochondrial dynamics in tissue regeneration, with specific attention on mitochondria-targeting biomaterials that accelerate multiple tissues' regeneration by regulating mitochondrial metabolism. The innovations in nanomaterials and nanosystems enhance mitochondrial-targeting therapies are critically examined with the prospects of modulating mitochondrial dynamics for new therapies in regenerative engineering.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123023"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PPS-TLR7/8 agonist nanoparticles equip robust anticancer immunity by selectively prolonged activation of dendritic cells.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-16 DOI: 10.1016/j.biomaterials.2024.123032

Yingxi Zhang, Yicheng Li, Zhaochu Xu, Linyi Xu, Yue Wang, Ning Li, Nicholas C Solek, Yongjun Wang, Bowen Li, Hongzhuo Liu

{"title":"PPS-TLR7/8 agonist nanoparticles equip robust anticancer immunity by selectively prolonged activation of dendritic cells.","authors":"Yingxi Zhang, Yicheng Li, Zhaochu Xu, Linyi Xu, Yue Wang, Ning Li, Nicholas C Solek, Yongjun Wang, Bowen Li, Hongzhuo Liu","doi":"10.1016/j.biomaterials.2024.123032","DOIUrl":"10.1016/j.biomaterials.2024.123032","url":null,"abstract":"Checkpoint inhibitor therapies do not benefit all patients, and adjuvants play a critical role in boosting immune responses for effective cancer immunotherapy. However, their systemic toxicity and suboptimal activation kinetics pose significant challenges. Here, this study presented a linker-based strategy to modulate the activation kinetics of Toll-like receptor 7/8 (TLR7/8) agonists delivered via poly (propylene sulfide) nanoparticles (PPS NPs). By covalently binding small molecule TLR7/8 agonists to PPS NPs with different linkers, enhanced therapeutic efficacy is achieved while abrogating systemic toxicity. These results showed that an alkyl linker selectively prolong the activation of DCs. It avoided the extensive activation of other APCs, favoring the limitation of immune-related toxicities. This strategy exhibited significant anti-tumor activity in alkyl linked nano-TLR7/8 agonists treatment alone, and cytokine and immune cell profiling provided evidence of prolonged immune cell activation in the tumor microenvironment, with evidence of an increase in the frequency of tumor antigen-specific CD8+ T cells. This linker-based approach offers a promising strategy to optimize the delivery of nano-TLR7/8 agonists for cancer immunotherapy, potentially advancing the field toward improved clinical outcomes.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123032"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential activation of osteogenic microenvironment via composite peptide-modified microfluidic microspheres for promoting bone regeneration.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-11-26 DOI: 10.1016/j.biomaterials.2024.122974

Liang Wu, Tao Xu, Sen Li, Kai Sun, Ziyang Tang, Hui Xu, Yong Qiu, Zhenhua Feng, Zhen Liu, Zezhang Zhu, Xiaodong Qin

{"title":"Sequential activation of osteogenic microenvironment via composite peptide-modified microfluidic microspheres for promoting bone regeneration.","authors":"Liang Wu, Tao Xu, Sen Li, Kai Sun, Ziyang Tang, Hui Xu, Yong Qiu, Zhenhua Feng, Zhen Liu, Zezhang Zhu, Xiaodong Qin","doi":"10.1016/j.biomaterials.2024.122974","DOIUrl":"10.1016/j.biomaterials.2024.122974","url":null,"abstract":"The osteogenic microenvironment (OME) significantly influences bone repair; however, reproducing its dynamic activation and repair processes remains challenging. In this study, we designed injectable porous microspheres modified with composite peptides to investigate cascade alterations in OME and their underlying mechanisms. Poly l-lactic acid microfluidic microspheres underwent surface modifications through alkaline hydrolysis treatment, involving heterogeneous grafting of bovine serum albumin nanoparticles with stem cell-homing peptides (BNP@SKP) and BMP-2 mimicking peptides (P24), respectively. These modifications well-organized the actions of initial release and subsequent in situ grafting of peptides. Cellular experiments demonstrated varied degrees of chemotactic recruitment and osteogenic differentiation in mesenchymal stem cells. Further biological analysis revealed that BNP@SKP targeted the Ras/Erk axis and upregulated matrix metalloproteinase (MMP)2 and MMP9 expression, thereby enhancing initial chemotaxis and recruitment. In vivo studies validated the establishment of a dynamically regulated OME centered on the microspheres, resulting in increased stem cell recruitment, sequential activation of the differentiation microenvironment, and facilitation of in situ osteogenesis without ectopic ossification. In conclusion, this study successfully fabricated composite peptide-modified microspheres and systematically explored the mechanisms of bone formation through sequential activation of OME via heterogeneous grafting of signaling molecules. This provides theoretical evidence for biomaterials based on microenvironment regulation.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"122974"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulating tumor cells to awaken T cell antitumor function and enhance melanoma immunotherapy.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-18 DOI: 10.1016/j.biomaterials.2024.123034

Weihan Zhang, Shijun Yuan, Zipeng Zhang, Shunli Fu, Shujun Liu, Jinhu Liu, Qingping Ma, Zhenxing Xia, Panpan Gu, Shuying Gao, Zhiyue Zhang, Xinke Zhang, Yongjun Liu, Na Zhang

{"title":"Regulating tumor cells to awaken T cell antitumor function and enhance melanoma immunotherapy.","authors":"Weihan Zhang, Shijun Yuan, Zipeng Zhang, Shunli Fu, Shujun Liu, Jinhu Liu, Qingping Ma, Zhenxing Xia, Panpan Gu, Shuying Gao, Zhiyue Zhang, Xinke Zhang, Yongjun Liu, Na Zhang","doi":"10.1016/j.biomaterials.2024.123034","DOIUrl":"10.1016/j.biomaterials.2024.123034","url":null,"abstract":"Tumor cells transmit various immunosuppressive signals and induce a dysfunctional state in T cells, which essentially leads to immune escape and tumor progression. However, developing effective strategies to counteract the domestication of T cells by tumor cells remains a challenge. Here, we prepared pH-responsive lipid nanoparticles (NL/PLDs) co-loaded with PCSK9 shRNA, lonidamine (LND), and low-dose doxorubicin (DOX). NL/PLDs can awaken domesticated T cells function by sending pro-activation, pro-recognition, and pro-killing signals by increasing tumor immunogenicity, increasing the expression of major histocompatibility complex I (MHC-I) on tumor cells, and alleviating the suppression effect of tumor-secreted lactic acid (LA) on the T cell effector function, respectively. In melanoma-bearing mice, NL/PLDs effectively relieved tumor immunosuppressive microenvironment (TIME) and enhanced the antitumor immunity mediated by CD8+ T cells. Furthermore, when combined with aPD-1, NL/PLDs demonstrated strong antitumor effects and increased immunotherapeutic efficacy. This regulatory strategy provides new insights for enhancing immunotherapy by regulating tumor immunosuppressive signals and shows significant potential for clinical tumor treatment.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123034"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A sequential stimuli-responsive hydrogel promotes structural and functional recovery of severe spinal cord injury.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-05 DOI: 10.1016/j.biomaterials.2024.122995

Hu Chen, Wanshun Wang, Yiming Yang, Beichen Zhang, Zefeng Li, Lingling Chen, Qiang Tu, Tao Zhang, Dingkun Lin, Honglei Yi, Hong Xia, Yao Lu

{"title":"A sequential stimuli-responsive hydrogel promotes structural and functional recovery of severe spinal cord injury.","authors":"Hu Chen, Wanshun Wang, Yiming Yang, Beichen Zhang, Zefeng Li, Lingling Chen, Qiang Tu, Tao Zhang, Dingkun Lin, Honglei Yi, Hong Xia, Yao Lu","doi":"10.1016/j.biomaterials.2024.122995","DOIUrl":"10.1016/j.biomaterials.2024.122995","url":null,"abstract":"Utilizing drug-loaded hydrogels to restore nerve conductivity emerges as a promising strategy in the treatment of spinal cord injury (SCI). However, many of these hydrogels fail to deliver drugs on demand according to the dynamic SCI pathological features, resulting in poor functional recovery. Inspired by the post-SCI microenvironments, here we report a time-sequential and controllable drug delivery strategy using an injectable hydrogel responsive to reactive oxygen species (ROS) and matrix metalloproteinases (MMPs). This strategy includes two steps: first, the hydrogel responds to ROS and releases nanodrugs to scavenge ROS, thereby mitigating inflammation and protecting neurons from oxidative stress in the initial SCI stages; second, the accumulation of MMPs triggers the release of vascular endothelial growth factor from nanodrugs to promote angiogenesis and neural stem cell differentiation in the late stage of SCI. In two clinically relevant SCI models, a single injection of the hydrogel led to an efficient structural and functional recovery of SCI 6 weeks after the intervention. We observed less inflammation, fibrosis, and cavities but more angiogenesis and neurons in the hydrogel-treated injured spinal cord region compared with the untreated animals. The hydrogel exhibits mechanical strength and conductivity comparable to natural spinal cord, facilitating its further clinical translation.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"122995"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A supramolecular assembly strategy for the treatment of rheumatoid arthritis with ultrasound-augmented inflammatory microenvironment reprograming. 通过超声增强炎症微环境重编程治疗类风湿性关节炎的超分子组装策略。

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-10 DOI: 10.1016/j.biomaterials.2024.123006

Fuhong Yang, Jingqi Lv, Yanli Huang, Wen Ma, Zhen Yang

{"title":"A supramolecular assembly strategy for the treatment of rheumatoid arthritis with ultrasound-augmented inflammatory microenvironment reprograming.","authors":"Fuhong Yang, Jingqi Lv, Yanli Huang, Wen Ma, Zhen Yang","doi":"10.1016/j.biomaterials.2024.123006","DOIUrl":"10.1016/j.biomaterials.2024.123006","url":null,"abstract":"As regulators and promotors of joint erosion, pro-inflammatory M1-like macrophages play pivotal roles in the pathogenesis of rheumatoid arthritis (RA). Here, we develop a supramolecular self-assembly (PCSN@MTX) of molybdenum (Mo) based polyoxometalate (POM), β-cyclodextrin (β-CD), and methotrexate (MTX), in which the MTX is loaded by host-guest interaction. PCSN@MTX shows inhibition of synovial M1-like macrophages polarization to alleviate RA. PCSN@MTX has demonstrated ultrasound (US) augmented catalytic behavior in consuming ROS and generating oxygen (O2) with accelerated conversion of Mo5+ to Mo6+ in the POM. In the collagen-induced arthritis mouse model, after systemical administration, the pH-responsive PCSN@MTX shows enhanced accumulation in the acidic joints by in-situ self-assembly. The host-guest complexation between MTX and β-CD is broken via US, achieving an on-demand burst release of MTX. The released MTX and ROS-scavenging synergistically facilitate the M1-to-M2 macrophage phenotype switching, which effectively alleviates RA disease progress under US irradiation. This study provides a paradigm for RA therapy with a promising US-augmented strategy.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123006"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of a transforming growth factor β1 functionalized silk sericin hydrogel through genetical engineering to repair alveolar bone defects in rabbit.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-04 DOI: 10.1016/j.biomaterials.2024.122986

Feng Wang, Anfeng Ning, Xuecheng Sun, Yujuan Zhou, Hanxin Deng, Hongji Zhou, Siyu Chen, Mengyao He, Zihan Meng, Yushu Wang, Hongfei Xia, Xu Ma, Qingyou Xia

{"title":"Fabrication of a transforming growth factor β1 functionalized silk sericin hydrogel through genetical engineering to repair alveolar bone defects in rabbit.","authors":"Feng Wang, Anfeng Ning, Xuecheng Sun, Yujuan Zhou, Hanxin Deng, Hongji Zhou, Siyu Chen, Mengyao He, Zihan Meng, Yushu Wang, Hongfei Xia, Xu Ma, Qingyou Xia","doi":"10.1016/j.biomaterials.2024.122986","DOIUrl":"10.1016/j.biomaterials.2024.122986","url":null,"abstract":"Cleft palate is one of the most prevalent congenital craniofacial birth defects in human congenital facial anomaly. Severe cleft palate is usually accompanied by alveolar bone defects (ABDs). Growth factors (GFs) are considered as desirable opportunity to promote the craniofacial healing post the surgery. However, limited resource, susceptibility to degradation, and lack of appropriate delivery systems greatly hinder the clinic application of GFs in the ABDs repair. In this study, a transforming growth factor β1 variant (eTGF-β1) with enhanced extracellular matrix (ECM) binding efficiency was engineered to generate transgenic silkworm using the silk gland biosynthesizing system for cost effective and massive bio-synthesis of the eTGF-β1 functionalized silk fibers. The eTGF-β1 achieved a highly-efficient expression in the middle silk gland (MSG) cells of transgenic silkworm, and secretion and distribution in the sericin layer of silk fiber which accounted for approximately 5.57 ± 0.72 % of the cocoon shell weight. The eTGF-β1 functionalized silk sericin hydrogel (eTGF-β1 SH) was then fabricated with excellent mechanical and processing properties, injectability, biocompatibility, biodegradability, sustained release of eTGF-β1, and capability to promote cell proliferation, which significantly accelerated the bone defect repair particularly the osteoblast maturation and new bone formation through regulating the expressions of the bone formation-related genes in a rabbit alveolar process cleft model. This study provides a valuable strategy for future the treatments of ABDs in rabbit with cleft palate using the genetically engineered eTGF-β1 silk sericin hydrogel.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"122986"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging nanomedicines for macrophage-mediated cancer therapy.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123028

Xueying Shi, Syed Faheem Askari Rizvi, Yinxian Yang, Gang Liu

{"title":"Emerging nanomedicines for macrophage-mediated cancer therapy.","authors":"Xueying Shi, Syed Faheem Askari Rizvi, Yinxian Yang, Gang Liu","doi":"10.1016/j.biomaterials.2024.123028","DOIUrl":"10.1016/j.biomaterials.2024.123028","url":null,"abstract":"Tumor-associated macrophages (TAMs) contribute to tumor progression by promoting angiogenesis, remodeling the tumor extracellular matrix, inducing tumor invasion and metastasis, as well as immune evasion. Due to the high plasticity of TAMs, they can polarize into different phenotypes with distinct functions, which are primarily categorized as the pro-inflammatory, anti-tumor M1 type, and the anti-inflammatory, pro-tumor M2 type. Notably, anti-tumor macrophages not only directly phagocytize tumor cells, but also present tumor-specific antigens and activate adaptive immunity. Therefore, targeted regulation of TAMs to unleash their potential anti-tumor capabilities is crucial for improving the efficacy of cancer immunotherapy. Nanomedicine serves as a promising vehicle and can inherently interact with TAMs, hence, emerging as a new paradigm in cancer immunotherapy. Due to their controllable structures and properties, nanomedicines offer a plethora of advantages over conventional drugs, thus enhancing the balance between efficacy and toxicity. In this review, we provide an overview of the hallmarks of TAMs and discuss nanomedicines for targeting TAMs with a focus on inhibiting recruitment, depleting and reprogramming TAMs, enhancing phagocytosis, engineering macrophages, as well as targeting TAMs for tumor imaging. We also discuss the challenges and clinical potentials of nanomedicines for targeting TAMs, aiming to advance the exploitation of nanomedicine for cancer immunotherapy.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123028"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage-hitchhiked, effervescence-induced nanoemulsions for enhanced oral chemotherapy and immunotherapy: Impact on absorption route.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123019

Nhien Nguyen, Tuyet-Mai Hoang, Tun-Yu Huang, Lam-Duc-Huy Nguyen, Hsiao-Huan Chang, Yen Chang, Mai Thanh Thi Nguyen, Kun-Ju Lin, Chun-Chieh Chen, Hsing-Wen Sung

{"title":"Macrophage-hitchhiked, effervescence-induced nanoemulsions for enhanced oral chemotherapy and immunotherapy: Impact on absorption route.","authors":"Nhien Nguyen, Tuyet-Mai Hoang, Tun-Yu Huang, Lam-Duc-Huy Nguyen, Hsiao-Huan Chang, Yen Chang, Mai Thanh Thi Nguyen, Kun-Ju Lin, Chun-Chieh Chen, Hsing-Wen Sung","doi":"10.1016/j.biomaterials.2024.123019","DOIUrl":"10.1016/j.biomaterials.2024.123019","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer. Paclitaxel (PTX), typically administered intravenously (IV) as chemotherapy, shows promise for triggering immunogenic cell death (ICD) and may serve as a potential immunotherapy. This study introduces an oral PTX delivery method using an enteric-coated gelatin capsule containing capric acid oil and an effervescent agent, optionally with decylamine-conjugated β-glucans (DA-βGlus). Upon dissolving in the small intestine, the capsule undergoes an effervescence reaction that produces emulsified oil droplets (ODs) by bile salts, forming either Bared/ODs/PTX or DA-βGlus/ODs/PTX, with the latter featuring surface-attached DA-βGlus. The study evaluates the oral absorption, pharmacokinetics, and therapeutic efficacy of these formulations, comparing them to IV administration. IV PTX causes rapid spikes in plasma concentration, quick metabolism, and elimination, which can be unsafe. In contrast, the oral delivery system maintains consistent drug levels in the bloodstream for longer periods, improving overall effectiveness. Bared/ODs/PTX follows conventional fat absorption pathways, limiting tumor targeting. On the other hand, DA-βGlus/ODs/PTX uses DA-βGlus to enhance specificity for tumors through endogenous macrophage-mediated transport, effectively acting as \"cellular tumor-seeking vehicles\". This method reduces tumor stroma fibrosis, delivers PTX precisely, induces apoptosis, triggers PTX-induced ICD, and enhances cytotoxic T cell responses, augmenting targeted anti-PDAC strategies.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123019"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomaterials and therapeutic strategies designed for tooth extraction socket healing.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-11-29 DOI: 10.1016/j.biomaterials.2024.122975

Yijia Yin, Fangyuan Shuai, Xian Liu, Yuxi Zhao, Xianglong Han, Hang Zhao

引用次数: 0