Biomaterials最新文献

{"title":"LNPs-mediated VEGF-C mRNA delivery promotes heart repair and attenuates inflammation by stimulating lymphangiogenesis post-myocardial infarction","authors":"Haonan Zhang,&nbsp;Huaiyu Jiang,&nbsp;Weichang Xie,&nbsp;Bei Qian,&nbsp;Qiang Long,&nbsp;Zhaoxi Qi,&nbsp;Shixing Huang,&nbsp;Yiming Zhong,&nbsp;Yecen Zhang,&nbsp;Lan Chang,&nbsp;Junjie Zhang,&nbsp;Qiang Zhao,&nbsp;Xinming Wang,&nbsp;Xiaofeng Ye","doi":"10.1016/j.biomaterials.2025.123410","DOIUrl":"10.1016/j.biomaterials.2025.123410","url":null,"abstract":"<div><div>Myocardial infarction (MI) initiates a strong inflammatory response, leading to adverse ventricular remodeling. The reconstruction of functional lymphatic networks is indispensable for relieving myocardial edema and regulating post-infarction inflammation. However, conventional protein-based therapies and viral delivery systems aimed at promoting lymphangiogenesis in the heart have shown limited therapeutic efficacy due to their inherent limitations. In this study, a lipid nanoparticle (LNP) platform encapsulating VEGF-C mRNA was developed as a novel approach to regulate gene expression and stimulate sustained lymphatic neogenesis after MI. Intramyocardial delivery of VEGF-C mRNA-loaded LNPs significantly promoted lymphangiogenesis, reduced the infiltration of inflammatory cells, and inhibited pro-inflammatory and fibrosis-associated signaling pathways. This ultimately resulted in a substantial reduction in the fibrotic area and improved functional recovery. Our findings demonstrated that VEGF-C mRNA@LNPs repair myocardial ischemic injury by facilitating immune modulation through lymphatic neogenesis, offering a promising new therapeutic strategy with strong translational potential for treating myocardial infarction.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123410"},"PeriodicalIF":12.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein-inspired in situ activatable photo-theranostic nitrobenzoselenadiazole-cholesterol for overcoming glioblastoma","authors":"Jong Min An ,&nbsp;Yeon Jin Lim ,&nbsp;Jiho Rhim ,&nbsp;Kyung Oh Jung ,&nbsp;Dokyoung Kim","doi":"10.1016/j.biomaterials.2025.123408","DOIUrl":"10.1016/j.biomaterials.2025.123408","url":null,"abstract":"<div><div>Photo-theranostic materials are designed for both diagnostic imaging and therapeutic applications under specific light sources, particularly in translational medicine. While various photo-theranostic materials have been developed for disease treatment, their cooperative effects on biologically abundant species, such as proteins, have rarely been studied in terms of biological activity. In this work, we disclose a photo-theranostic agent (named NBSD-Chol) based on nitrobenzoselenadiazole (NBSD) and cholesterol (Chol), which is activatable in situ through lipoprotein hybridization. NBSD-Chol demonstrates outstanding potential for cancer imaging and photodynamic therapy (PDT) due to its unique properties, including (i) tumor targeting after oral uptake, (ii) tumor visualization under light irradiation for image-guided surgery, (iii) superior PDT effects, and (iv) downgrading hazard ratios (HR) related to clinically critical proteins. Overall, this work contributes to advancing translational medicine by developing innovative treatments for cancer using visible light, ushering in a new era of intraoperative technology and photodynamic fluorescence-guided surgical agents.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123408"},"PeriodicalIF":12.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stiff bioink for hybrid bioprinting of vascularized bone tissue with enhanced mechanical properties","authors":"Majd Machour ,&nbsp;Roy Meretzki ,&nbsp;Yuval Moshe Haizler ,&nbsp;Margarita Shuhmaher ,&nbsp;Dina Safina ,&nbsp;Mark M. Levy ,&nbsp;Shulamit Levenberg","doi":"10.1016/j.biomaterials.2025.123406","DOIUrl":"10.1016/j.biomaterials.2025.123406","url":null,"abstract":"<div><div>3D bioprinting is an emerging technique in tissue engineering that is advantageous for fabricating intricate tissues. However, challenges arise in bioprinting functional, implantable tissues. Commonly utilized hydrogel bioinks, while offering desirable printability and a cell-friendly environment, often lack the mechanical robustness necessary for post-printing maturation, handling, and implantation. These limitations are particularly relevant for bone tissue. Treatment of bone loss resulting from trauma or infection poses a significant clinical challenge. While surgical interventions exist, they frequently lead to complications and limited outcomes. Thus, a strategy to enhance the mechanical integrity of bioprinted constructs compatible with cells is needed. This study presents a novel hybrid bioprinting approach to create mechanically robust, vascularized bone tissue. A reinforcing bioink composed of a poly(lactic-co-glycolic) acid (PLGA), hydroxyapatite (HA), and polyethylene-glycol microparticles blend, which is thermosensitive due to a reduced glass transition temperature (∼36 °C), enabling sintering at physiological conditions is co-printed with a cell-laden, ECM-based hydrogel. The microparticles sinter at 37 °C, forming a porous, stiff scaffold. The hybrid bioprinted constructs demonstrate high cell viability, vascular network formation, and osteogenic differentiation. In vivo implantation in a rat femoral defect reveals superior bone regeneration compared to acellular controls. This study highlights the potential of hybrid bioprinting for creating tissues exhibiting high cell viability and enhanced mechanical properties, allowing for their handling and implantation.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123406"},"PeriodicalIF":12.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative DNA tetrahedron inspired by ancient mortise-and-tenon technique offers new immunotherapy strategy for metastatic breast cancer","authors":"Nan Zhang ,&nbsp;Lu Qian ,&nbsp;Chang Xu ,&nbsp;Fangfang Duan ,&nbsp;Yuxuan Ma ,&nbsp;Li Zhou ,&nbsp;Yuting Zhang ,&nbsp;Yi Ma ,&nbsp;Qiao Lin ,&nbsp;Kai Lu","doi":"10.1016/j.biomaterials.2025.123390","DOIUrl":"10.1016/j.biomaterials.2025.123390","url":null,"abstract":"<div><div>Framework nucleic acids effectively meet the demands for precise size control and accurate targeting in the design of drug delivery systems, while developing a controllable drug delivery system with low immunogenicity and high efficiency for delivering nucleic acid drugs to the tumor immune microenvironment (TIME) remains significant challenge. Inspired by ancient Chinese <em>mortise and tenon</em> joint structures, this study develops an intelligent self-assembling DNA tetrahedron (TDN@siCSF-1R), which consists of a gapped DNA tetrahedron (TDN) and a therapeutic siRNA against Colony-Stimulating Factor-1 Receptor (siCSF-1R) that non-covalently bind with TDN via its gap, aiming to target tumor-associated macrophages (TAMs) and inhibit the CSF-1R pathway. Additionally, a CD206 mRNA-responsive sequence is introduced into the gapped TDN, triggering the site-specific release of siCSF-1R in M2-like TAMs, thereby achieving the precise targeting of CSF-1R in M2-like TAMs and reducing off-target effect. The <em>mortise-and-tenon</em>-like TDN@siCSF-1R synchronously combines the self-assembly flexibility and structural stability, significantly inhibiting 4T1 tumor growth, lung metastasis, and tumor recurrence after resection in vivo. Furthermore, it repolarizes M2-like TAMs and activates infiltrating T cells in TIME, thereby reshaping the immunosuppressive microenvironment, and offering a promising strategy for the clinical application of cancer immunotherapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123390"},"PeriodicalIF":12.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'A simple soft lithographic route to fabrication of poly(ethylene glycol) microstructures for protein and cell patterning' [Biomaterials Volume 25 Issue 3, (2004) Pages 557-563].","authors":"Kahp Y Suh, Jiehyun Seong, Ali Khademhosseini, Paul E Laibinis, Robert Langer","doi":"10.1016/j.biomaterials.2025.123362","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123362","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"123362"},"PeriodicalIF":12.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significantly enhanced capture efficiency of cell-imprinted material for circulating tumor cells via a flexible and ultra-strong double-armed phenylboronic acid design","authors":"Wenjing Sun ,&nbsp;Xinmiao Zhao ,&nbsp;Xinjia Zhao ,&nbsp;Lingkai Meng ,&nbsp;Mingliang Tang ,&nbsp;Jiaqi Li ,&nbsp;Yongxin Chang ,&nbsp;Yuting Xiong ,&nbsp;Hao Wang ,&nbsp;Jinghua Chen ,&nbsp;Guangyan Qing","doi":"10.1016/j.biomaterials.2025.123397","DOIUrl":"10.1016/j.biomaterials.2025.123397","url":null,"abstract":"<div><div>Circulating tumor cells (CTC) have been incontrovertibly regarded as a critically essential detection tool within the realm of cancer combat, being decidedly preferred by oncology clinicians and serving as the preponderant primary targets for single-cell analysis. However, several challenges hinder the effective capture of CTC from blood, including their rarity, heterogeneity across cancer types, the complexity of the blood environment, and potential damage to cell viability. Here we design a flexible double-armed phenylboric acid (DPBA) that targets double-branched sialylated glycans (SGs) on the surface of liver CTC. The binding affinity of DPBA (200 nM) is 33 times greater than that of typical phenylboric acid, as confirmed by glycoproteomics analysis demonstrating a strong prevalence for SGs. By copolymerization of DPBA with polyethylene glycol dimethacrylate (PEGDMA), using SMMC-7721 cells as templates, we developed a cell-imprinted hydrogel featuring compact polymeric networks interconnected by both chemical crosslinking and hydrogen bonding. This hydrogel exhibits an ultra-low swelling capacity of 5 %, effectively preserving the nano- and micro-morphologies of cell imprinting. It also demonstrates low protein adhesion, appropriate elasticity and reversibility, as well as satisfactory blood and cell compatibility. The high affinity for double-branched SGs and clear cell imprinting endow the material with precise capture efficiency for CTC, enabling accurate discrimination between liver cancer patients and healthy individuals, with an excellent area under the curve (AUC) of 0.99 and a high classification accuracy of 96 %. Importantly, the captured CTC could be released alive for genomics analysis. The material costs just 1.98 dollars per sample, which is only 1/200th of the typical medical price. This study highlights the significant potential of flexible double-armed molecular design in the development of CTC capture materials, which will promote downstream single-cell multi-proteomics analysis and facilitate early cancer diagnostics.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"322 ","pages":"Article 123397"},"PeriodicalIF":12.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Bioprinting 3D microfibrous scaffolds for engineering cardiac tissues and heart-on-a-chip' [Biomaterials Volume 110, (2016) Pages 45-59].","authors":"Yu Shrike Zhang, Andrea Arneri, Simone Bersini, Su Ryon Shin, Kai Zhu, Zahra Goli-Malekabadi, Julio Aleman, Cristina Colosi, Fabio Busignani, Valeria Dell'Erba, Colin Bishop, Thomas Shupe, Danilo Demarchi, Matteo Moretti, Marco Rasponi, Mehmet Remzi Dokmeci, Anthony Atala, Ali Khademhosseini","doi":"10.1016/j.biomaterials.2025.123363","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123363","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"123363"},"PeriodicalIF":12.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Direct 3D bioprinting of perfusable vascular constructs using a blend bioink' [Biomaterials Volume 106, (2016) Pages 58-68].","authors":"Weitao Jia, P Selcan Gungor-Ozkerim, Yu Shrike Zhang, Kan Yue, Kai Zhu, Wanjun Liu, Qingment Pi, Batzaya Byambaa, Mehmet Remzi Dokmeci, Su Ryon Shin, Ali Khademhosseini","doi":"10.1016/j.biomaterials.2025.123364","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123364","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"123364"},"PeriodicalIF":12.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Atmosphere-inspired multilayered nanoarmor with modulable protection and delivery of Interleukin-4 for inflammatory microenvironment modulation\" [Biomaterials 301 (2023) 122254].","authors":"Xin Ge, Junfeng Hu, Yuan Peng, Zhuo Zeng, Danfeng He, Xilan Li, Yajie Chen, Gaoxing Luo, Jun Deng, Zhigang Xu, Song He","doi":"10.1016/j.biomaterials.2025.123291","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123291","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"123291"},"PeriodicalIF":12.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneum-inspired adaptive hydrogel sheath orchestrating long-term lubrication and antibacterial properties for drainage tube intubation","authors":"Zhi-Guo Wang ,&nbsp;Ming Cai ,&nbsp;Xue Xiao ,&nbsp;Run-Lin Sun ,&nbsp;Xi Liao ,&nbsp;Rui Hong ,&nbsp;Ju-Xiang Gou ,&nbsp;Ka Li ,&nbsp;Jia-Zhuang Xu ,&nbsp;Zhong-Ming Li","doi":"10.1016/j.biomaterials.2025.123405","DOIUrl":"10.1016/j.biomaterials.2025.123405","url":null,"abstract":"<div><div>Drainage tube (DT) intubation is frequently accompanied by distressing and even life-threatening complications. Herein, we engineer a peritoneum-inspired adaptive hydrogel sheath orchestrating long-term lubrication and broad-spectrum antibacterial properties onto the commercially-available DT surface for safe medical intervention. A thin conformal hydrogel sheath is formed by constructing the semi-interpenetrating hydrogel network to serve as the hydration layer, mimicking the lubricative peritoneal fluid layer of the peritoneum. The exposed protonated amino group of the semi-interpenetrating hydrogel network imparts the hydrogel sheath with an intrinsic antibacterial capacity, imitating the peritoneal inherent immunoregulatory function that resists bacterial invasion. The resultant hydrogel sheath exhibits the long-term lubricity, prominent broad-spectrum antibacterial property, remarkable robustness in various harsh environments, and excellent antifouling property without comprising biocompatibility. As demonstrated by an <em>in vivo</em> rabbit model of peritoneal drainage, the application of the hydrogel sheath on DT not only alleviates skin tissue trauma and inflammation effectively, but also inhibits bacterial invasion to avoid potential infection. The current work opens a valuable avenue to develop the functional DT to meet clinical needs.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"323 ","pages":"Article 123405"},"PeriodicalIF":12.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}