Biomaterials最新文献

{"title":"A cationic main-chain poly(carbonate-imidazolium) potent against Mycobacterium abscessus and other resistant bacteria in mice.","authors":"Zhangyong Si, Yan Sun, Chongyun Tan, Ying Jie Ooi, Ming Li, Cheerlavancha Raju, Jamal Shubi, Yunn-Hwen Gan, Yabin Zhu, Peng Li, Mary B Chan-Park, Kevin Pethe","doi":"10.1016/j.biomaterials.2024.123003","DOIUrl":"10.1016/j.biomaterials.2024.123003","url":null,"abstract":"<p><p>The incidence of serious lung infections due to Mycobacterium abscessus, a worrying non-tuberculosis mycobacteria (NTM) species, is rising and has in some countries surpassed tuberculosis. NTM are ubiquitous in the environment and can cause serious lung infections in people who are immunocompromised or have pre-existing lung conditions. M. abscessus is intrinsically resistant to most antibiotics. Current treatments involve combination of three or more repurposed antibiotics with the treatment regimen lasting at least 12 months but producing unsatisfactory success rates of less than 50 %. Herein, we report an alternative strategy using a degradable polymer, specifically main-chain cationic carbonate-imidazolium-derived polymer (MCOP-1). MCOP-1 is a non-toxic agent active in a murine lung infection model. MCOP-1 also exhibits excellent efficacy against multi-drug resistant (MDR) ESKAPE bacteria. MCOP-1 damages bacterial membrane and DNA, and serial passaging does not rapidly elicit resistance. Its carbonate linkage is stable enough to allow MCOP-1 to remain intact for long enough to exert its bactericidal effect but is labile over longer time periods to degrade into non-toxic small molecules. These findings underscore the potential of degradable MCOP-1 as a promising therapeutic antimicrobial agent to address the growing incidence of recalcitrant infections due to M. abscessus and MDR ESKAPE bacteria.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123003"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface modification of decellularized kidney scaffold with chemokine and AKI-CKD cytokine juice to increase the recellularization efficiency of bio-engineered kidney.","authors":"Minji Choi, Md Abdullah Al Fahad, Prayas Chakma Shanto, Seong-Su Park, Byong-Taek Lee","doi":"10.1016/j.biomaterials.2024.123007","DOIUrl":"10.1016/j.biomaterials.2024.123007","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is a prevalent global health issue, primarily caused by glomerular dysfunction, diabetes, endovascular disorders, hypertensive nephrosclerosis, and other vascular diseases. Despite the increase in available organ sources, significant challenges remain in securing organ compatibility, prompting extensive research into creating a bio-artificial kidney free from immune rejection. In this study, a bio-engineered kidney was established using a stem cell chemoattractant within a bioreactor system; rBMSCs were used to recellularize the decellularized kidney scaffold coated with SDF-1α/AKI-CKD cytokine juice under mimic-hypoxic conditions as these chemokines and cytokines are crucial for the cell migration. LC-MS/MS proteomic analysis of the scaffold suggested that it contains various important proteins related to angiogenesis, cell migration, differentiation, etc. The in-silico binding simulation and Immunohistochemical (IHC) staining were utilized to detect the coated chemokines and cytokines. Cells were administered through both ureter and arterial routes of the kidney scaffold to differentiate into epithelial and endothelial cells. After 14 days of the recellularization process utilizing a mimic-hypoxia-induced bioreactor, the SDF-1α/AKI-CKD CJ-coated kidney scaffold exhibited high levels of cell attachment, migration, and proliferation in both the cortex and medulla. Additionally, the coating of the cytokines remarkably enhanced the expression of specific renal cell markers within the complex microfilter-like tubular structures. This study underscores a recellularization strategy that addresses the challenges associated with constructing bio-artificial kidneys and contributes to the growing field of bio-artificial organ research.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123007"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bioprinted and scalable model of human tubulo-interstitial kidney fibrosis.","authors":"Daphne Bouwens, Nazanin Kabgani, Cédric Bergerbit, Hyojin Kim, Susanne Ziegler, Sadaf Ijaz, Ali Abdallah, Tamás Haraszti, Sidrah Maryam, Abdolrahman Omidinia-Anarkoli, Laura De Laporte, Sikander Hayat, Jitske Jansen, Rafael Kramann","doi":"10.1016/j.biomaterials.2024.123009","DOIUrl":"10.1016/j.biomaterials.2024.123009","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) affects more than 10% of the global population. As kidney function negatively correlates with the presence of interstitial fibrosis, the development of new anti-fibrotic therapies holds promise to stabilize functional decline in CKD patients. The goal of the study was to generate a scalable bioprinted 3-dimensional kidney tubulo-interstitial disease model of kidney fibrosis. We have generated novel human PDGFRβ⁺ pericytes, CD10⁺ epithelial and CD31⁺ endothelial cell lines and compared their transcriptomic signature to their in vivo counterpart using bulk RNA sequencing in comparison to human kidney single cell RNA-sequencing datasets. This comparison indicated that the novel cell lines still expressed kidney cell specific genes and shared many features with their native cell-state. PDGFRβ⁺ pericytes showed three-lineage differentiation capacity and differentiated towards myofibroblasts following TGFβ treatment. We utilized a fibrinogen/gelatin-based hydrogel as bioink and confirmed a good survival rate of all cell types within the bioink after printing. We then combined all three cells in a bioprinted model using separately printed compartments for tubule epithelium, and interstitial endothelium and pericytes. We confirmed that this 3D printed model allows to recapitulate key disease driving epithelial-mesenchymal crosstalk mechanisms of kidney fibrosis since injury of epithelial cells prior to bioprinting resulted in myofibroblast differentiation and fibrosis driven by pericytes after bioprinting. The bioprinted model was also scalable up to a 96-well format.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123009"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring osteoimmunity and hemostasis using 3D-Printed nano-photocatalytic bactericidal scaffold for augmented bone regeneration.","authors":"Sayan Deb Dutta, Jin Hexiu, Md Moniruzzaman, Tejal V Patil, Rumi Acharya, Jong Sung Kim, Ki-Taek Lim","doi":"10.1016/j.biomaterials.2024.122991","DOIUrl":"10.1016/j.biomaterials.2024.122991","url":null,"abstract":"<p><p>Bone hemorrhage, infection, and large bone defects following surgical treatment of traumatic bone injury have raised potential concerns, underscoring the urgent need to develop multifunctional therapeutic platforms that can effectively address traumatic bone regeneration. Advancements in three-dimensional (3D) printing technology have propelled the development of several engineering disciplines, such as tissue engineering. Nevertheless, 3D-printed frameworks with conventional materials often lack multifunctional capabilities to promote specific activities for diverse regeneration purposes. In this study, we developed a highly oxidized two-dimensional (2D) graphitic carbon nitride (Ox-gCN) as a nano-photocatalyst to reinforce alginate/gelatin (ALG)-based hydrogel scaffolds (ALG/CN) to achieve an anti-inflammatory and osteo-immunomodulatory niche with superior hemostatic ability for traumatic bone injury repair. Sulfuric acid oxidation enhances the oxygen-containing functional groups of the g-CN surface and promotes cell adhesion and differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro. Moreover, the excellent visible light-activated photocatalytic characteristics of the ALG/CN scaffold were used in antibacterial studies. In addition, the ALG/CN bio/nanocomposite scaffold facilitates M2 polarization of macrophages than did pristine ALG scaffolds. Furthermore, ALG/CN scaffold induced hBMSCs differentiation by upregulating ERK and MAPKs phosphorylation during osteo-immunomodulation. In a rat calvaria defect model, the fabricated ALG/CN scaffolds induced new bone formation through collagen deposition and activation of osteocalcin proteins without inflammation in vivo. These results highlight the potential of 3D-printed functionalized 2D carbon nitrides in regulating the bone immune microenvironment, which may be beneficial for developing advanced tissue constructs, especially for traumatic bone regeneration in clinical settings.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"122991"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pickering emulsion with tumor vascular destruction and microenvironment modulation for transarterial embolization therapy.","authors":"Lei Zhang, Duo Wang, Lin-Zhu Zhang, Wei-Hao Yang, Chao Yu, Juan Qin, Liang-Zhu Feng, Zhuang Liu, Gao-Jun Teng","doi":"10.1016/j.biomaterials.2024.123018","DOIUrl":"10.1016/j.biomaterials.2024.123018","url":null,"abstract":"<p><p>In the clinic, Lipiodol chemotherapeutic emulsions remain a main choice for patients diagnosed with hepatocellular carcinoma (HCC) via the mini-invasive transarterial chemoembolization (TACE) therapy. However, the poor stability of conventional Lipiodol chemotherapeutic emulsions would result in the fast drug diffusion and incomplete embolization, inducing systemic toxicity and impairing the efficacy of TACE therapy. Therefore, it is of great importance to construct alternative formulations based on commercial Lipiodol to achieve the improved efficacy and safety of HCC treatment. Herein, calcium phosphate (CaP) nanoparticles-stabilized Lipiodol Pickering emulsion (CaP-LPE) with improved stability and pH-responsiveness is prepared and utilized for the encapsulation of combretastatin A4-phosphate (CA4P), a clinically approved vascular disrupting agent. The obtained CA4P-loaded CaP-LPE (CCaP-LPE) was shown to be enhanced stability compared to conventional Lipiodol emulsion and pH-responsive release of the encapsulated drugs. On one hand, the released CA4P could disrupt tumor vascular and cut off the blood supplying of tumor cells, thus starving cancer cells. Moreover, it was revealed that CCaP-LPE could reverse immunosuppressive tumor microenvironment (TME) by neutralizing tumor acidity, leading to the increased infiltration of CD8⁺ T cells and the decreased percentages of immunosuppressive cells. As the result, such CCaP-LPE could effectively shrink orthotopic N1S1 HCC tumors in rats by eliciting a potent antitumor immune response. Therefore, this study highlights a simple strategy to construct a novel LPE with the potencies of tumor vascular disruption and TME modulation, holding a great promise for TAE therapy of HCC.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123018"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A super soft thermoplastic biodegradable elastomer with high elasticity for arterial regeneration.","authors":"Yating Jia, Xin Xu, Hao Lu, Kanwal Fatima, Yali Zhang, Haibo Du, Jin Yang, Xiaojun Zhou, Xiaofeng Sui, Lei Hou, Yanan Pang, Chuanglong He","doi":"10.1016/j.biomaterials.2024.122985","DOIUrl":"10.1016/j.biomaterials.2024.122985","url":null,"abstract":"<p><p>Elastomers with innovative performance will provide new opportunities for solving problems in soft tissue repair, such as arterial regeneration. Herein, we present a thermoplastic biodegradable elastomer (PPS) that differs from the rigid, low-elastic traditional ones. It shows super softness (0.41 ± 0.052 MPa), high stretchability (3239 ± 357 %), and viscoelasticity similar to natural soft tissues. In addition, it also has good processability and appropriate degradability, estimated at 4-8 months for complete degradation in vivo. This excellent overall performance makes it a great support material for soft tissue repair and a powerful modifying agent for improving existing materials. For example, introducing it into poly(l-lactide) scaffolds through thermally induced phase separation can create a unique microporous structure with interconnected large pores (diameter >10 μm), demonstrating high efficiency in inducing cell infiltration. Blending it with poly(ε-caprolactone) through electrospinning can produce a composite fibrous film with significantly improved comprehensive performance, displaying artery-matched mechanical properties. Building on the above, we constructed a tri-layer tissue-engineered vascular graft for arterial regeneration, exhibiting promising remodeling outcomes in rabbits.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"122985"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure.","authors":"Lingjun Tong, Qiyue Wang, Yameng Zhang, Fengling Lai, Jiarun Xu, Wenchao Yin, Sitong Zhang, Guoyue Wei, Jie Yin, Huaxi Yi, Gert Storm, Zhaoyang Wang, Rong Huang, Tao Xu, Jiong-Wei Wang","doi":"10.1016/j.biomaterials.2024.122976","DOIUrl":"10.1016/j.biomaterials.2024.122976","url":null,"abstract":"<p><p>miR30d has been shown to reverse cardiac hypertrophy. However, effective delivery of miR30d to the heart is challenging. Here, we engineered milk-derived extracellular vesicles (mEVs) by surface functionalization with an ischemic myocardium-targeting peptide (IMTP) and encapsulated miR30d to develop a formulation, the miR30d-mEVs^IMTP, enabling targeted delivery of miR30d to the injured heart. In vitro, the miR30d-mEVs^IMTP can be effectively internalized by hypoxia-induced H9C2 cells via the endo-lysosomal pathway. In the isoproterenol (ISO)-induced cardiac hypertrophy mice, more miR30d-mEVs^IMTP accumulated in cardiac tissue than miR30d-mEVs following intravenous administration. As a result, miR30d-mEVs^IMTP alleviated cardiac hypertrophy and rescued cardiac function in three murine models of hypertrophic heart failure. Mechanistically, we identified GRK5 as an unprecedented target of miR30d in cardiac hypertrophy. Taken together, our findings demonstrate that mEVs conjugated with IMTP effectively deliver miR30d to the pathological heart and thereby ameliorating cardiac hypertrophy and dysfunction via targeting GRK5-mediated signaling pathways.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"122976"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amplifying Ca²⁺ overload by engineered biomaterials for synergistic cancer therapy.","authors":"Jun-Long Liang, Yangyang Cao, Kaiwei Lv, Bing Xiao, Jihong Sun","doi":"10.1016/j.biomaterials.2024.123027","DOIUrl":"10.1016/j.biomaterials.2024.123027","url":null,"abstract":"<p><p>Ca²⁺ overload is one of the most widely causes of inducing apoptosis, pyroptosis, immunogenic cell death, autophagy, paraptosis, necroptosis, and calcification of tumor cells, and has become the most valuable therapeutic strategy in the field of cancer treatment. Nevertheless, several challenges remain in translating Ca²⁺ overload-mediated therapeutic strategies into clinical applications, such as the precise control of Ca²⁺ dynamics, specificity of Ca²⁺ homeostasis dysregulation, as well as comprehensive mechanisms of Ca²⁺ regulation. Given this, we comprehensively reviewed the Ca²⁺-driven intracellular signaling pathways and the application of Ca²⁺-based biomaterials (such as CaCO₃-, CaP-, CaO₂-, CaSi-, CaF₂-, and CaH₂-) in mediating cancer diagnosis, treatment, and immunotherapy. Meanwhile, the latest researches on Ca²⁺ overload-mediated therapeutic strategies, as well as those combined with multiple-model therapies in mediating cancer immunotherapy are further highlighted. More importantly, the critical challenges and the future prospects of the Ca²⁺ overload-mediated therapeutic strategies are also discussed. By consolidating recent findings and identifying future research directions, this review aimed to advance the field of oncology therapy and contribute to the development of more effective and targeted treatment modalities.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123027"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hijacking endogenous iron to amplify lysosomal-mitochondrial cascade damage for boosting anti-tumor immunotherapy.","authors":"Hanghang Liu, Menglong Hua, Yaobao Han, Li Yang, Zhongshi Huang, Jiabing Ran, Huimin Wang, Feng Ren, Changying Yang, Zhen Li","doi":"10.1016/j.biomaterials.2024.122983","DOIUrl":"10.1016/j.biomaterials.2024.122983","url":null,"abstract":"<p><p>The cross-talk between lysosomes and mitochondria is crucial for keeping intracellular homeostasis and metabolic function, providing a promising approach for tumor therapy. Herein, we employed polyvinylpyrrolidone (PVP)-modified Cu-gallic acid (CuGA) complex nano-boosters for amplifying lysosomes-mitochondria cascaded damage, and thereby effectively inducing cuproptosis and pyroptosis of breast tumor cells to boost anti-tumor immunotherapy. The CuGA nano-boosters could hijack lysosomal iron to form a bimetallic catalyst Cu(Fe)GA in situ through ion-exchange reaction, and cause the release of Cu^+/2+ and metal ion dysregulation (i.e., Fe^2+/3+, Cu^+/2+, Ca²⁺) in tumor cells. The released Cu⁺ further led to metabolic disturbances of mitochondrial tricarboxylic acid (TCA) cycle (i.e., cuproptosis), and ultimately led to caspase-3/GSDME-dependent pyroptosis. In vivo results revealed that this lysosomal-mitochondrial cascade damage strategy not only induced tumor cell death, but also activated the immune response, thereby effectively suppressed tumor metastasis. This research provides a novel approach of triggering cascade damage to subcellular organelles for boosting tumor immunotherapy by disrupting metal ion intracellular homeostasis.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"122983"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced oral breviscapine sustained-release tablets for improved ischemic stroke treatment.","authors":"Tingting Hao, Guangwei Jiang, Chenteng Lin, Cyrille Boyer, Rongqin Huang","doi":"10.1016/j.biomaterials.2024.123030","DOIUrl":"10.1016/j.biomaterials.2024.123030","url":null,"abstract":"<p><p>This study aimed to address the challenges associated with the low oral bioavailability and the necessity for frequent dosing of breviscapine (BRE), a mainstream drug in the treatment of cardiovascular and cerebrovascular diseases. The poor solubility and permeability of BRE in the gastrointestinal tract were identified as significant barriers to effective drug absorption, thereby impacting therapeutic efficacy and patient compliance. To enhance the gastrointestinal absorption of BRE, particles loaded with BRE were engineered utilizing Cremophor EL (CrEL), an absorption enhancer, in conjunction with mesoporous silica, a biocompatible drug delivery vector, formulating mesoporous silica particles loaded with BRE and CrEL (BRE-CrEL@SiO₂). The solubility and mucosal permeability of BRE were ameliorated, facilitating transepithelial transport and improving absorption kinetics. BRE-CrEL@SiO₂ were subsequently integrated to prepare sustained-release tablets. The finite element simulation method was utilized in the study of non-planar circular BRE tablet process to ensure tablet quality. The superior bioavailability and therapeutic index of the absorption-promoting sustained-release tablets, compared to commercial tablets, were validated through in vivo pharmacokinetic and pharmacodynamic assessments, while safety was maintained. The oral relative bioavailability of the absorption-enhancing sustained-release tablets was 160.7 % relative to the commercial tablets, demonstrated in Beagle dogs, indicating higher absorption. This innovative formulation represents a significant advancement in improving therapeutic efficacy of ischemic stroke and reducing the treatment burden on patients. The study provides new insights into the development of novel dosage forms for BRE and other drugs with poor solubility and permeability, suggesting a promising approach to enhance their therapeutic effectiveness and improve patient compliance in treatment.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123030"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}