Biomaterials最新文献

{"title":"Lactate metabolism regulating nanosystem synergizes cuproptosis and ferroptosis to enhance cancer immunotherapy","authors":"Hui Zhi ,&nbsp;Weimin Yin ,&nbsp;Shiyu Chen ,&nbsp;Xiaoyou Zhang ,&nbsp;Zichen Yang ,&nbsp;Fulong Man ,&nbsp;Rongjie Li ,&nbsp;Yanni Cai ,&nbsp;Yang Li ,&nbsp;Caoyi You ,&nbsp;Yan Li ,&nbsp;Yongyong Li ,&nbsp;Haiqing Dong","doi":"10.1016/j.biomaterials.2025.123538","DOIUrl":"10.1016/j.biomaterials.2025.123538","url":null,"abstract":"<div><div>Cuproptosis and ferroptosis exhibit superior synergistic advantages in antitumor therapy. While glutathione (GSH) has been identified as a key molecule in enhancing the synergistic effects of these two processes, inherent cellular redox homeostasis mechanisms limit its therapeutic efficacy. This inspired us to explore other new regulators to potentiate the synergistic effect. Through bioinformatics analysis and preliminary experimental validation, we discovered that lactate metabolism is closely associated with both ferroptosis and cuproptosis. Therefore, this work strategically targets lactate metabolism to synergistically activate cuproptosis and ferroptosis, and elucidate its immunotherapeutic mechanisms. For this purpose, we constructed a Syr-loaded nanodelivery system (Syr@mPDA@CP) using biocompatible mesoporous polydopamine (mPDA) as the carrier. Upon targeting tumor tissues, the released Syr significantly inhibits lactate efflux, leading to intracellular lactate accumulation. This lactate buildup further induces intracellular acidification, exerting dual effects: (1) promoting ferritin (FTH1) dissociation to release endogenous iron stores, thereby elevating intracellular iron levels; and (2) suppressing glycolysis and reducing ATP levels, which inactivates the copper export protein ATP7B. Combined with copper peroxide (CP)-derived Cu²⁺, these effects synergistically amplify intracellular copper accumulation. The elevated intracellular Cu and Fe concentrations subsequently induce dual cell death pathways of cuproptosis and ferroptosis, effectively enhancing cancer immunotherapy. This study pioneers a lactate metabolism-regulating strategy to synergistically amplify both ferroptosis and cuproptosis, offering novel perspectives for antitumor therapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123538"},"PeriodicalIF":12.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gold-embedded yolk-shell mesoporous organosilica nanocomposite for microwave-enhanced targeted chemotherapy and immune modulation in hepatocellular carcinoma","authors":"Wei Tian ,&nbsp;Hanyao Sun ,&nbsp;Ziqing Xu ,&nbsp;Na Li ,&nbsp;Xi Luo ,&nbsp;Yang Li ,&nbsp;Jiaqi Xu ,&nbsp;Jiajia Tang ,&nbsp;Yafei Luo ,&nbsp;Jie Zhang ,&nbsp;Chen Yuan ,&nbsp;Shangyu Lu ,&nbsp;Haibin Shi ,&nbsp;Shouju Wang ,&nbsp;Sheng Liu","doi":"10.1016/j.biomaterials.2025.123533","DOIUrl":"10.1016/j.biomaterials.2025.123533","url":null,"abstract":"<div><div>Microwave ablation (MWA), an innovative therapy for hepatocellular carcinoma (HCC), faces challenges of limited thermal effects and a tumor immunosuppressive microenvironment. Addressing these, we developed an advanced Au@PMO@DOX-Lac nanocomposite, aimed at enhancing the microwave thermal effect, while simultaneously facilitating targeted chemotherapy and immunomodulation. This nanocomposite, incorporating gold-embedded yolk-shell mesoporous organosilica nanoparticles, amplifies microwave thermal effects from two aspects: molecular hotspots created at the gold-silica interface and the confinement effect within its hollow nanostructure. These enhancements facilitate more effective tumor ablation with reduced microwave power requirements and shorter treatment durations. Additionally, surface modification with lactobionic acid and loading with doxorubicin allow the nanocomposite to perform precise, targeted synergistic chemotherapy. After ablation, the nanocomposite increased cytotoxic T cells and reduced regulatory T cells, while shifting macrophages from the immunosuppressive M2 to the anti-tumor M1 phenotype, significantly enhancing localized and systemic anti-tumor immune responses. Overall, this multifunctional nanocomposite not only overcomes the thermal limitations of MWA but also addresses the tumor's immunosuppressive environment, providing a promising approach for treating HCC and potentially other cancers with similar therapeutic challenges.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123533"},"PeriodicalIF":12.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable polymers with tertiary amines enhance mRNA delivery of lipid nanoparticles via improved endosomal escape","authors":"Feng Zhao ,&nbsp;Bruno Luppi ,&nbsp;Po-Han Chao ,&nbsp;Jinfan Yang ,&nbsp;Ying Zhang ,&nbsp;Ran Feng ,&nbsp;Vanessa Chan ,&nbsp;Ramya Kannan ,&nbsp;Songtao Dong ,&nbsp;Athan Gogoulis ,&nbsp;Leo Wang ,&nbsp;Angel Lee ,&nbsp;Zachary Hudson ,&nbsp;Shyh-Dar Li","doi":"10.1016/j.biomaterials.2025.123541","DOIUrl":"10.1016/j.biomaterials.2025.123541","url":null,"abstract":"<div><div>Messenger RNA (mRNA)-based therapy has become a promising and scalable approach for treating various diseases, and lipid nanoparticles (LNPs) have recently gained prominence as a safe and effective delivery vehicle. LNPs not only protect mRNA from degradation during systemic circulation but also facilitate its intracellular uptake and endosomal release. However, the endosomal release efficiency of standard LNPs has been shown to be poor, limiting the transfection efficiency. Here, we explored incorporating a biodegradable polymer which only contains tertiary amines as a pH-sensitive functional group into LNPs, aiming to introduce the proton sponge effect to facilitate the endosomal release. We developed a series of novel LNP formulations by spiking the polymers with different molecular weights into LNPs at a range of ratios. Our results demonstrated that the polymer-modified LNPs (<em>p</em>-LNPs) maintained a particle size of approximately 80 nm, a neutral surface charge, and an mRNA encapsulation efficiency &gt;90 %, along with increased pH buffering capacity. The optimal <em>p</em>-LNP formulation tripled the cellular uptake and enhanced the endosomal escape efficiency from 20 % to 80 % compared to the standard LNPs. Furthermore, cells treated with the <em>p</em>-LNP formulation at 1 mg/mL showed no cytotoxicity. Upon intravenous administration, the optimal <em>p</em>-LNP formulation loaded with luciferase mRNA significantly increased the transgene expression evidenced by a 100-fold increase in luciferin bioluminescence from the liver compared to the standard LNPs. Moreover, <em>p</em>-LNPs did not elevate inflammatory cytokines in the treated mice, including IFN-gamma, IL1β, TNFα, and IL6.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123541"},"PeriodicalIF":12.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A leucine derivate-adjuvanted LNP vaccine enhances antitumor immunity through mTOR activation and metabolic reprograming in dendritic cells","authors":"You Zhou ,&nbsp;Yongyi Xie ,&nbsp;Jialong Qi ,&nbsp;Jialin Hu ,&nbsp;Yi Yang ,&nbsp;Fei Deng ,&nbsp;Yongcheng Zhu ,&nbsp;Wei Deng ,&nbsp;Lin Mei ,&nbsp;Ewa M. Goldys ,&nbsp;Jianye Zhang ,&nbsp;Chuanshan Xu ,&nbsp;Wenjie Chen","doi":"10.1016/j.biomaterials.2025.123539","DOIUrl":"10.1016/j.biomaterials.2025.123539","url":null,"abstract":"<div><div>Neoantigen-derived peptide vaccines have been emergingly employed to treat tumors, however, their inefficient delivery and antigenicity remain challenging. In this study, for the first time a leucine derivate LLOMe (L-leucyl-<span>l</span>-leucine methyl ester) was repurposed to the adjuvant to reinforce the immune responses of lipid nanoparticle (LNP)-based peptide vaccine. Mechanistically, LLOMe disrupted the lysosomal entrapment of vaccine thus effectively enhanced bioavailability of antigens. Moreover, LLOMe in vaccine was found to stimulate the functional level of APCs via mTOR programed metabolism, while mTOR inhibitor rapamycin could abolish the adjuvating effect of LLOMe. In various animal tumor models receiving prophylactic or therapeutic vaccinations adjuvanted by LLOMe, the effective suppression of tumor growth was achieved through enhanced delivery of antigens and modulation of cellular immune responses. This study demonstrated that LLOMe-induced adjuvanticity significantly enhance the anti-tumor immunity of LNP vaccines, providing a clinically translational and potent adjuvant strategy for developing cancer vaccines.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"325 ","pages":"Article 123539"},"PeriodicalIF":12.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Sandwich” structured nanorods for timely antibiosis, immunoregulation and neuroangiogenesis to accelerate osteogenesis of Zn-based implants in diabetics","authors":"Yang Xue ,&nbsp;Lan Zhang ,&nbsp;Mengting Mao ,&nbsp;Shengda Wu ,&nbsp;Yingang Zhang ,&nbsp;Yong Han","doi":"10.1016/j.biomaterials.2025.123540","DOIUrl":"10.1016/j.biomaterials.2025.123540","url":null,"abstract":"<div><div>Pathological microenvironment of diabetes predisposes to induce bacterial infection, sustained inflammatory response, and impaired neuroangiogenesis, impeding fracture repair. Zn-based implants have great potential to replace conventional Ti implants as temporary fixations, but their osseointegration ability needs improvement. In this work, “sandwich” structured nanorods were constructed on Zn substrate with ZnO nanorods as core, riboflavin-encapsulated ZIF-8 as intermediate layer and HA as outer shell. Under normal physiological condition, ZIF-8 and HA reduce degradation of Zn substrate, decreasing Zn²⁺ release. ZIF-8 and riboflavin scavenge extracellular and intracellular ROS, respectively, achieving antioxidant therapy and establishing anti-inflammatory microenvironment via promoting M1 macrophages to polarize toward M2 phenotype. The synergistic effect of Zn²⁺, riboflavin as well as cytokines secreted by macrophages up-regulates the vitality and biological functions of BMSCs, HUVECs and PC-12 cells <em>in vitro</em>. When bacteria invade, they secrete hyaluronidase and organic acids to decompose HA and ZIF-8 sequentially, releasing a mass of Zn²⁺, which increases bacterial membrane permeability and induces intracellular ROS production and protein leakage, leading to bacterial death. The comprehensive effects of the “sandwich” structured nanorods on antibiosis, anti-inflammatory and neuroangiogenesis to accelerate osseointegration are further confirmed in an infected diabetic model, exhibiting great promise for Zn-based implants in clinical application.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123540"},"PeriodicalIF":12.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'Pathology-targeted cell delivery via injectable micro-scaffold capsule mediated by endogenous TGase' [Biomaterials, 126 (2017), 17950].","authors":"Chunxiao Qi, Yaqian Li, Patrick Badger, Hongsheng Yu, Zhifeng You, Xiaojun Yan, Wei Liu, Yan Shi, Tie Xia, Jiahong Dong, Chenyu Huang, Yanan Du","doi":"10.1016/j.biomaterials.2025.123536","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123536","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"123536"},"PeriodicalIF":12.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cell membrane camouflaged mesoporous polydopamine for Parkinson's disease treatment via alleviating oxidative stress mediated neuroinflammation","authors":"Yuqin Chen ,&nbsp;Wei Lv ,&nbsp;Jiangna Xu ,&nbsp;Shengnan Li ,&nbsp;Kefan Song ,&nbsp;Yue Gong ,&nbsp;Wei Zhao ,&nbsp;Hongli Liu ,&nbsp;Zhenwei Ding ,&nbsp;Linfeng Liu ,&nbsp;Jiaqing Yin ,&nbsp;Dan Su ,&nbsp;Ming Lu ,&nbsp;Xiangming Fang ,&nbsp;Hongliang Xin","doi":"10.1016/j.biomaterials.2025.123537","DOIUrl":"10.1016/j.biomaterials.2025.123537","url":null,"abstract":"<div><div>Excessive accumulation of reactive oxygen species (ROS) in Parkinson's disease (PD) leads to oxidative stress, which induces neuroinflammation and accelerates disease progression. To address this, we developed mPDA@MSC, a nanosystem consisting of mesoporous polydopamine (mPDA) nanoparticles coated with a mesenchymal stem cell membrane (MSCm), which exhibits ROS-scavenging properties. The mPDA structure significantly enhanced ROS-scavenging and anti-inflammatory activities, while the surface-encapsulated MSCm enabled effective blood-brain barrier traversal and targeted the lesion site in the PD brain. Both <em>in vitro</em> and <em>in vivo</em> studies demonstrated that mPDA@MSC exerted anti-Parkinsonian effects through multiple mechanisms, including ROS scavenging, modulation of mitochondrial dysfunction, and promotion of the transition from pro-inflammatory to anti-inflammatory microglial phenotypes. This resulted in the reversal of dopaminergic neuron damage, inhibition of α-synuclein (α-syn) production, and improvement in behavioral deficits and other phenotypes. These findings highlight the potential of mPDA@MSC as a therapeutic agent for PD and introduce a novel approach to anti-PD therapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123537"},"PeriodicalIF":12.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An omics-based drug-HIFU combination therapy discovery for ferroptosis treatment of TNBC","authors":"Ruizhe Xu ,&nbsp;Xiaomin Su ,&nbsp;Xifeng Qin ,&nbsp;Yue Liu ,&nbsp;Jiayi Wu ,&nbsp;Xuejing Li ,&nbsp;Ting Wang ,&nbsp;Xingyue Gong ,&nbsp;Boshu Ouyang ,&nbsp;Huiwen Liu ,&nbsp;Wuli Yang ,&nbsp;Jun Zhang ,&nbsp;Bo Zhang ,&nbsp;Zhiqing Pang","doi":"10.1016/j.biomaterials.2025.123535","DOIUrl":"10.1016/j.biomaterials.2025.123535","url":null,"abstract":"<div><div>Combination therapy, as a vital strategy in cancer treatment, aims to overcome the limitations of monotherapies by combining two or more drugs or treatments to enhance antitumor efficacy. However, the unclear interactions between different therapies and the difficulty of precisely identifying effective combination treatments remain major challenges. In this study, we developed an omics-based drug-HIFU combination therapy discovery framework taking ferroptosis treatment of triple-negative breast cancer (TNBC) as a paradigm. Using the transcriptomics of a large TNBC cohort, drug sensitivity databases, and transcriptomics of high-intensity focused ultrasound (HIFU)-treated cells, the interaction network between HIFU, key ferroptosis genes, and potential drugs was constructed to predict and identify novel drugs that target ferroptosis and synergize with HIFU. It was found that 11 candidate ferroptosis drugs demonstrated synergistic cytotoxicity with HIFU in 4T1 cells, which lacked previous reports. Especially, HIFU, by upregulating IL-6 expression by 2.69-fold, reduced the IC50 of panobinostat in 4T1 cells by 5.27-fold. Panobinostat was subsequently loaded into platelet-mimicking liposomes (Pan-PML) for tumor targeted drug delivery to amplify the synergistic effect of panobinostat and HIFU. Importantly, the combination of HIFU and Pan-PML resulted in significant inhibition of tumor growth in the 4T1 tumor model, with 50 % of mice remaining free of tumor and lung metastasis compared to those treated with HIFU or Pan-PML alone. Mechanistically, it was discovered that Pan-PML, in combination with HIFU, significantly inhibited histone deacetylase (HDAC) activity to 1/50 of the original level and further reduced the expression of the ferroptosis-related gene SIRT3 to 19.17 % of baseline, thereby synergistically promoting ferroptosis in tumor cells and activating anti-tumor immunity. Thus, this omics-based drug-HIFU combination therapy discovery framework provides an innovative method to screen the combination therapy, which leverages the synergistic effects of existing drugs and HIFU and enables combination treatments to maximize antitumor efficacy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123535"},"PeriodicalIF":12.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient organic nanoparticles for photothermal antibacterial activity and immune regulation to promote maxillofacial wound healing and scarless repair","authors":"Shu Lou ,&nbsp;Changyue Xing ,&nbsp;Jiarong Zhang ,&nbsp;Qifei Yang ,&nbsp;Wentao Wang ,&nbsp;Yuxing Qian ,&nbsp;Ben Zhong Tang ,&nbsp;Ming Zhang ,&nbsp;Yongchu Pan","doi":"10.1016/j.biomaterials.2025.123534","DOIUrl":"10.1016/j.biomaterials.2025.123534","url":null,"abstract":"<div><div>Treating maxillofacial infections is hindered by severe inflammation and bacterial biofilms, which delay healing and often result in significant scarring. Photothermal therapy (PTT), which utilizes a photothermal agent (PTA) to generate localized heat, presents a promising approach that effectively eliminates pathogens while minimizing tissue damage, thereby enhancing treatment safety and efficacy. However, challenges such as low photothermal conversion efficiency and biocompatibility issues persist. In this study, we developed hemin chloride-modified organic small molecule-based nanoparticles (PTA@Hemin NPs). This material demonstrates exceptional photothermal effects with 81 % photothermal conversion efficiency and excellent biocompatibility. Under near-infrared (NIR) laser irradiation, the PTA@Hemin NPs generate strong photothermal effects, which synergize with the inherent antibacterial properties of hemin to significantly enhance the eradication of free bacteria and biofilms. Furthermore, PTA@Hemin NPs effectively scavenge reactive oxygen species (ROS) and alleviate inflammation by downregulating the expression of pro-inflammatory factors such as Cd86 and Il-1α, reducing M1 macrophage polarization. Both <em>in vitro</em> and <em>in vivo</em> experiments confirmed that PTA@Hemin NPs significantly enhance antibacterial and anti-inflammatory effects, while facilitating scarless healing of maxillofacial wounds in mice. These results highlight the potential of PTA@Hemin NPs as a highly effective strategy for treating bacterial infections, particularly those involving biofilms, in future clinical applications.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123534"},"PeriodicalIF":12.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A heterogeneous hydrogel patch with mechanical activity and bioactivity for chronic diabetic wound healing","authors":"Suyang Dai ,&nbsp;Lingchen Mao ,&nbsp;Xiongwei Chen ,&nbsp;Jie Zhang ,&nbsp;Xin Li ,&nbsp;Maosheng Zhang ,&nbsp;Ni Jiang ,&nbsp;Keda Yang ,&nbsp;Shun Duan ,&nbsp;Zhihua Gan ,&nbsp;Zhenbo Ning","doi":"10.1016/j.biomaterials.2025.123531","DOIUrl":"10.1016/j.biomaterials.2025.123531","url":null,"abstract":"<div><div>Chronic wounds are common complications for diabetic patients, characterized by difficult healing because of the persistent and excessive inflammatory response, susceptibility to infection, and a lack of effective contraction stress at the diabetic wound site. In this study, we develop a heterogeneous hydrogel patch through the in situ free radical polymerization of acrylamide (AM) in the presence of modified alginate (Alg-Cat) within a porous polyurethane foam (DDLPU-foam). The polyurethane foam containing demethylated dealkaline lignin-Fe³⁺ complex structures (DDL-Fe³⁺) with photothermal properties endows the patches with excellent near-infrared (NIR) light-responsive shape memory performance, allowing the pre-stretched patches to provide biaxial contraction for diabetic wounds under NIR light, while also providing broad-spectrum photothermal antibacterial properties. The Alg-Cat in the hydrogel phase contains disulfide-linked catechol, offering antioxidant activity and flexible tissue adhesion. In vivo tests demonstrate that the DDLPU/Alg-Cat patch effectively reduces the inflammation level of chronic wound and promote tissue reconstruction, accelerating wound healing through combined mechanical modulation function and antioxidant activity. This heterogeneous hydrogel patch possesses both mechanical modulation function and bioactivity, providing a novel and effective strategy for treating chronic diabetic wounds.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123531"},"PeriodicalIF":12.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}