Biomaterials最新文献_第5页

Cationic conjugated polymers with tunable hydrophobicity for efficient treatment of multidrug-resistant wound biofilm infections.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123015

Ahmed Nabawy, Aritra Nath Chattopadhyay, Jessa Marie V Makabenta, Muhammad Aamir Hassan, Junwhee Yang, Jungmi Park, Mingdi Jiang, Taewon Jeon, Jungkyun Im, Vincent M Rotello

{"title":"Cationic conjugated polymers with tunable hydrophobicity for efficient treatment of multidrug-resistant wound biofilm infections.","authors":"Ahmed Nabawy, Aritra Nath Chattopadhyay, Jessa Marie V Makabenta, Muhammad Aamir Hassan, Junwhee Yang, Jungmi Park, Mingdi Jiang, Taewon Jeon, Jungkyun Im, Vincent M Rotello","doi":"10.1016/j.biomaterials.2024.123015","DOIUrl":"10.1016/j.biomaterials.2024.123015","url":null,"abstract":"Biofilm-associated infections arising from antibiotic-resistant bacteria pose a critical challenge to global health. We report the generation of a library of cationic conjugated poly(phenylene ethynylene) (PPE) polymers featuring trimethylammonium terminated sidechains with tunable hydrophobicity. Screening of the library identified an amphiphilic polymer with a C11 hydrophobic spacer as the polymer with the highest antimicrobial efficacy against biofilms in the dark with excellent selectivity. These polymers are highly fluorescent, allowing label-free monitoring of polymer-bacteria/biofilm interactions. The amphiphilic conjugated polymer penetrated the biofilm matrix in vitro and eradicated resident bacteria through membrane disruption. This C11 polymer was likewise effective in an in vivo murine model of antibiotic-resistant wound biofilm infections, clearing >99.9 % of biofilm colonies and efficient alleviation of biofilm-associated inflammation. The results demonstrate the therapeutic potential of the fluorescent conjugated polymer platform as a multi-modal antimicrobial and imaging tool, surpassing conventional antimicrobial strategies against resilient biofilm infection.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123015"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-niche human bone marrow on-a-chip for studying the interactions of adoptive CAR-T cell therapies with multiple myeloma.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123016

Delta Ghoshal, Ingrid Petersen, Rachel Ringquist, Liana Kramer, Eshant Bhatia, Thomas Hu, Ariane Richard, Reda Park, Jenna Corbin, Savi Agarwal, Abel Thomas, Sebastian Ramirez, Jacob Tharayil, Emma Downey, Frank Ketchum, Abigail Ochal, Neha Sonthi, Sagar Lonial, James N Kochenderfer, Reginald Tran, Mandy Zhu, Wilbur A Lam, Ahmet F Coskun, Krishnendu Roy

{"title":"Multi-niche human bone marrow on-a-chip for studying the interactions of adoptive CAR-T cell therapies with multiple myeloma.","authors":"Delta Ghoshal, Ingrid Petersen, Rachel Ringquist, Liana Kramer, Eshant Bhatia, Thomas Hu, Ariane Richard, Reda Park, Jenna Corbin, Savi Agarwal, Abel Thomas, Sebastian Ramirez, Jacob Tharayil, Emma Downey, Frank Ketchum, Abigail Ochal, Neha Sonthi, Sagar Lonial, James N Kochenderfer, Reginald Tran, Mandy Zhu, Wilbur A Lam, Ahmet F Coskun, Krishnendu Roy","doi":"10.1016/j.biomaterials.2024.123016","DOIUrl":"10.1016/j.biomaterials.2024.123016","url":null,"abstract":"Multiple myeloma (MM), a cancer of bone marrow plasma cells, is the second-most common hematological malignancy. However, despite immunotherapies like chimeric antigen receptor (CAR)-T cells, relapse is nearly universal. The bone marrow (BM) microenvironment influences how MM cells survive, proliferate, and resist treatment. Yet, it is unclear which BM niches give rise to MM pathophysiology. Here, we present a 3D microvascularized culture system, which models the endosteal and perivascular bone marrow niches, allowing us to study MM-stroma interactions in the BM niche and model responses to therapeutic CAR-T cells. We demonstrated the prolonged survival of cell line-based and patient-derived multiple myeloma cells within our in vitro system and successfully perfused in donor-matched CAR-T cells. We then measured T cell survival, differentiation, and cytotoxicity against MM cells using a variety of analysis techniques. Our MM-on-a-chip system could elucidate the role of the BM microenvironment in MM survival and therapeutic evasion and inform the rational design of next-generation therapeutics.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123016"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiotherapy-immunomodulated nanoplatform triggers both hypoxic and normoxic tumor associated antigens generation for robust abscopal effect and sustained immune memory.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-10 DOI: 10.1016/j.biomaterials.2024.123005

Jie Li, Chenfeng Tan, Jin Yang, Zhongzheng Xiang, Yan Wang, Meiling Shen, Shunyao Zhu, Tao He, Xiuqi Liang, Bianfei Shao, Haijun Li, Zhike Li, Lei Liu, Changyang Gong

{"title":"Radiotherapy-immunomodulated nanoplatform triggers both hypoxic and normoxic tumor associated antigens generation for robust abscopal effect and sustained immune memory.","authors":"Jie Li, Chenfeng Tan, Jin Yang, Zhongzheng Xiang, Yan Wang, Meiling Shen, Shunyao Zhu, Tao He, Xiuqi Liang, Bianfei Shao, Haijun Li, Zhike Li, Lei Liu, Changyang Gong","doi":"10.1016/j.biomaterials.2024.123005","DOIUrl":"10.1016/j.biomaterials.2024.123005","url":null,"abstract":"Radiotherapy (RT) induced abscopal effect has garnered substantial attention, nevertheless, it is rarely observed in clinics, due to the tumor hypoxia-related radioresistance, inadequate immune stimulation, and immunosuppressive tumor microenvironment. Herein, we construct a radiotherapy-immunomodulated nanoplatform (THUNDER), which synergizes with RT and greatly triggers the generation of both hypoxic and normoxic tumor cells-derived tumor-associated antigens (TAAs), resulting in robust abscopal effect and sustained immune memory. THUNDER exhibits prolonged blood circulation and high tumor retention capacity. When combined with RT, THUNDER effectively destructs both hypoxic and normoxic tumor cells, facilitating the substantial release of TAAs from both cell types, which further promotes the maturation of dendritic cells (DCs), thus forming powerful immune stimulation and initiating systemic anti-tumor immunity. In murine models, the combination of THUNDER and RT efficiently suppresses the growth of triple-negative breast cancer. In addition, the further combination with PD-L1 blockade yields noteworthy suppression of distant metastasis and tumor recurrence, resulting in a 5.2-fold augmentation in CD8+ T lymphocytes within distant tumors and a 2.8-fold increase in effector memory T cells in the spleen. In conclusion, the radiotherapy-immunomodulated nanoplatform presents an effective strategy for combating tumor metastases and recurrence by eliciting both hypoxic and normoxic TAAs, offering a significant avenue for radioimmunotherapy.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123005"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antigen self-presenting dendrosomes swallowing nanovaccines boost antigens and STING agonists codelivery for cancer immunotherapy.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-09 DOI: 10.1016/j.biomaterials.2024.122998

Jiaxuan Xia, Xing Chen, Meichen Dong, Shengyao Liu, Longlong Zhang, Junjie Pan, Jianxin Wang

{"title":"Antigen self-presenting dendrosomes swallowing nanovaccines boost antigens and STING agonists codelivery for cancer immunotherapy.","authors":"Jiaxuan Xia, Xing Chen, Meichen Dong, Shengyao Liu, Longlong Zhang, Junjie Pan, Jianxin Wang","doi":"10.1016/j.biomaterials.2024.122998","DOIUrl":"10.1016/j.biomaterials.2024.122998","url":null,"abstract":"Cancer vaccines show promise by eliciting tumor-specific cytotoxic T lymphocytes (CTL) responses. Efficient cytosolic co-delivery of antigens and adjuvants to dendritic cells (DCs) is crucial for vaccines to induce anti-tumor immunity. However, peptide- or nucleic acid-based biomolecules like tumor antigens and STING agonist cyclic-di-GMP (cdGMP) are prone to endosomal degradation, resulting in low cytosolic delivery and CTL response rates. Cationic nanocarriers can improve cytosolic delivery, but their positive charges induce off-target effects. Here, we develop cationic poly(ester amide) based nanoparticles co-loaded with antigens and adjuvant cdGMP (NP(cG, OVA)) for efficient cytosolic delivery and swallow them within antigen self-presenting DCs-derived dendrosomes (ODs) for lymph nodes (LNs) homing. The constructed dendrosomes swallowing nanovaccines ODs/NP(cG, OVA) demonstrated significantly reduced liver accumulation and enhanced LNs and DCs targeting compared to NP(cG, OVA). ODs/NP(cG, OVA) effectively cross-dressed the antigen epitopes on the shell to DCs and facilitated internalization of NP(cG, OVA), realizing DCs cytosolic co-delivery of antigens and adjuvants, thereby promoting antigen presentation, maturation and inflammatory cytokines secretion of DCs. Consequently, DCs stimulated by ODs/NP(cG, OVA) effectively induced activation, proliferation, and differentiation of antigen-specific CTLs that provided robust immune protection against tumor invasion. This work presents a powerful vaccine strategy for cancer immunotherapy.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"122998"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox-activatable inhalable mucoadhesive proteinic nanotherapeutics for targeted treatment of lung cancer.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-09 DOI: 10.1016/j.biomaterials.2024.123004

Yeonsu Jeong, Yun Seop Shim, Yun Kee Jo, Hyung Joon Cha

{"title":"Redox-activatable inhalable mucoadhesive proteinic nanotherapeutics for targeted treatment of lung cancer.","authors":"Yeonsu Jeong, Yun Seop Shim, Yun Kee Jo, Hyung Joon Cha","doi":"10.1016/j.biomaterials.2024.123004","DOIUrl":"10.1016/j.biomaterials.2024.123004","url":null,"abstract":"Inhalation delivery has been considered a promising choice for treating lung cancer because it can shuttle therapeutic payloads directly to cancer tissues via simple and noninvasive procedures while reducing systemic toxicity. However, its clinical application still faces challenges, especially for delivering hydrophobic chemotherapeutic drugs, due to poor absorption on mucosal tissues and limited therapeutic performance. Herein, we propose inhalable mucoadhesive proteinic nanoparticles (NPs) capable of facilitating reliable pulmonary drug delivery and redox-responsive anticancer therapeutic effects to realize noninvasive, localized treatment of lung cancer in a highly biocompatible, site-specific manner. Thiolated mussel adhesive protein (MAP)-based NPs (thMAP NPs) can be administered to target tissues via an easy and facile nebulization process due to their superior MAP-driven adhesion ability and sufficient structural integrity. Curcumin (Cur)-loaded thMAP NPs (thMAP@Cur NPs) demonstrated efficient cellular uptake through the thiol-mediated pathway and controlled the intracellular release of Cur in response to the reductive environment in cancer cells. The nebulized thMAP@Cur NPs elicited prolonged retention in lung tissue without causing any detectable adverse effects, leading to significant inhibition of metastatic lung cancer in vivo. Thus, these protein-based redox-responsive mucoadhesive NPs hold great promise as robust inhalable drug delivery platforms to achieve effective, localized treatment of pulmonary cancer and other respiratory diseases.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123004"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lighthouses illuminating tumor metastasis: The application of fluorescent probes in the localization and imaging metastatic lymph nodes across various tumors.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123020

Qi Dang, Linhao Zhang, Huipeng Ma, Xiaoshan Sun, Anguo Ren, Jiuyang Chen, Xiaohua Huang, Boyu Zhang, Wen Sun

{"title":"Lighthouses illuminating tumor metastasis: The application of fluorescent probes in the localization and imaging metastatic lymph nodes across various tumors.","authors":"Qi Dang, Linhao Zhang, Huipeng Ma, Xiaoshan Sun, Anguo Ren, Jiuyang Chen, Xiaohua Huang, Boyu Zhang, Wen Sun","doi":"10.1016/j.biomaterials.2024.123020","DOIUrl":"10.1016/j.biomaterials.2024.123020","url":null,"abstract":"The significance of metastatic lymph nodes in tumor diagnosis and prognosis is self-evident. With the deepening of research on the lymphatic system and the advancement of imaging technology, an increasing number of near-infrared fluorescent probes targeting tumor metastatic lymph nodes have been developed. These probes can identify tumors while further detecting lymph nodes (LNs), showcasing great potential in image-guided surgery. In this review, we comprehensively outline the design strategies and applications of near-infrared fluorescent probes for cancers with a high propensity for lymph node metastasis during disease progression. Particular emphasis is placed on two targeting mechanisms: tumor-directed probes capable of identifying metastatic lymph nodes and lymph node-specific probes utilizing passive targeting of metastatic lymph nodes or active targeting of lymph nodes directly. Additionally, we discuss current issues and future prospects in this field, which will facilitate the development of new fluorescent probes and their further clinical translation.","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"316 ","pages":"123020"},"PeriodicalIF":12.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial clustering biomaterials as anti-infective therapies.

IF 12.8 1区医学

Biomaterials Pub Date : 2025-05-01 Epub Date: 2024-12-15 DOI: 10.1016/j.biomaterials.2024.123017

Nhan Dai Thien Tram, Jian Xu, Kiat Hwa Chan, Lakshminarayanan Rajamani, Pui Lai Rachel Ee

引用次数: 0

Corrigendum to "Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity" [Biomaterials 314 (2025) 122908].

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 Epub Date: 2024-11-28 DOI: 10.1016/j.biomaterials.2024.122973

Sumanta Ghosh, Mengjia Zheng, Jiahui He, Yefeng Wu, Yaming Zhang, Weiping Wang, Jie Shen, Kelvin W K Yeung, Prasanna Neelakantan, Chenjie Xu, Wei Qiao

引用次数: 0

Corrigendum to "Poly(β-amino ester) polymer library with monomer variation for mRNA delivery" [Biomaterials 314 (2025) 122896]. 用于递送 mRNA 的具有单体变化的聚（β-氨基酯）聚合物库"[《生物材料》314 (2025) 122896]的更正。

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 Epub Date: 2024-11-22 DOI: 10.1016/j.biomaterials.2024.122966

Hong Lyun Kim, Gurusamy Saravanakumar, Seowon Lee, Subin Jang, Seonwoo Kang, Mihyeon Park, Sivasangu Sobha, So-Hee Park, Soo-Min Kim, Jung-Ah Lee, Eunkyung Shin, You-Jin Kim, Hye-Sook Jeong, Dokeun Kim, Won Jong Kim

引用次数: 0

Corrigendum to 'Enhancing CAR-T cell therapy against solid tumor by drug-free triboelectric immunotherapy' [Biomaterials 314 (2025) 122871]. 通过无药三电免疫疗法增强针对实体瘤的 CAR-T 细胞疗法"[《生物材料》314 (2025) 122871] 勘误。

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 Epub Date: 2024-10-31 DOI: 10.1016/j.biomaterials.2024.122927

Haimei Li, Zichen Wang, Yulin Hu, Guangqin He, Liang Huang, Yi Liu, Zhong Lin Wang, Peng Jiang

引用次数: 0