Biomaterials最新文献

{"title":"High-performance cartilage tissue bioink for 3D bioprinting with minimal post-processing for articular cartilage regeneration","authors":"Sujin Noh ,&nbsp;Yong Jun Jin ,&nbsp;Dong Il Shin ,&nbsp;Hyeon Jae Kwon ,&nbsp;Hee-Woong Yun ,&nbsp;Soon Hee Kim ,&nbsp;Jae-Young Park ,&nbsp;Jun Young Chung ,&nbsp;Sumin Lim ,&nbsp;Do Young Park","doi":"10.1016/j.biomaterials.2025.123873","DOIUrl":"10.1016/j.biomaterials.2025.123873","url":null,"abstract":"<div><div>Despite recent advances, clinical translation of articular cartilage remains limited. This is primarily due to engineering challenges and safety issues associated with extensive post-printing steps, including the reliance on exogenous growth factors and cross-linking agents. To overcome these limitations, we developed a high-performance cartilage Tissue bioink incorporating porcine synovium-derived mesenchymal stem cell (pSMSCs) mesenchymal condensation process augmented by decellularized cartilage extracellular matrix (DCECM) to facilitate intrinsic chondrogenesis without additional biochemical cues. The Tissue bioink exhibited a homogeneous distribution of pSMSCs and DCECM, with increase in cartilage-specific ECM components. Proteomic analysis further demonstrated increased cartilage ECM components and pathways associated with matrix remodeling and chondrogenesis via TGF-β1/SMAD signaling axis. Rheological analysis confirmed that the bioink exhibited shear-thinning behavior and rapid recovery of structural integrity, ensuring stable printability. Optimized printing parameters supported high cell viability. After 14 days of culture without growth factors or cross-linking agents, the printed constructs exhibited a twofold increase in sulfated glycosaminoglycan and collagen deposition, further validating their ongoing chondrogenic potential. In a porcine full-thickness cartilage defect model, Tissue bioink-printed constructs promoted robust cartilage regeneration, demonstrating enhanced ECM deposition, histological cartilage characteristics, and significantly improved biomechanical properties (p &lt; 0.001) at six months. Furthermore, PKH-26-labeled pSMSCs persisted within the defect site, indicating sustained cellular viability and potential contribution to tissue remodeling. These findings suggest that DCECM-augmented mesenchymal condensation provides a biomimetic biofabrication strategy that enhances chondrogenesis without the need for post-printing growth factors and cross-linking steps, presenting a promising approach for a clinically translatable cartilage repair.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123873"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmon-boosted titanium nitride-based nanoplatform for synergistic photothermal-chemodynamic cancer therapy with smart degradability","authors":"Ruiqi Yang ,&nbsp;Zhu You ,&nbsp;Bojun Xie ,&nbsp;Mingyang Liu ,&nbsp;Eva Yazmin Santiago ,&nbsp;Lucas V. Besteiro ,&nbsp;Yong Wang ,&nbsp;Baojin Ma ,&nbsp;Hong Liu ,&nbsp;Dongling Ma","doi":"10.1016/j.biomaterials.2025.123950","DOIUrl":"10.1016/j.biomaterials.2025.123950","url":null,"abstract":"<div><div>The development of multifunctional nanoplatforms offers promising strategies for advancing cancer treatment, given the generally limited efficacy of single function nanomaterial-based therapeutics. Herein, a plasmon-enhanced “sandwich-like” nanoplatform, titanium nitride@mesoporous silica-iron oxide/polyethylenimine (TiN@mSiO₂-Fe₃O₄/PEI), is designed for synergistic photothermal and chemodynamic therapy (PTT/CDT). The core comprises multiple TiN nanoparticles exhibiting strong plasmon coupling, while the mSiO₂ shell is decorated with ultrasmall, surface-exposed Fe₃O₄ nanozymes (∼3.2 nm) to facilitate catalytic reactions with tumor-associated substrates. Under near-infrared irradiation, the nanoplatform demonstrates a favorable photothermal conversion efficiency (∼39.3 %), making it well-suited for mild-temperature PTT. Meanwhile, the localized heat generated by TiN effectively enhances the catalytic activity of adjacent Fe₃O₄ nanozymes, thereby promoting hydroxyl radical production and intracellular glutathione depletion. The synergistic photothermal-catalytic interactions within TiN@mSiO₂-Fe₃O₄/PEI result in augmented therapeutic effect by combining efficient PTT with intensified CDT by <em>in situ</em> thermally accelerated Fenton reactions. This is evidenced by &gt;90 % cancer cell killing efficiency <em>in vitro</em> and ∼96 % tumor inhibition rate in MOC1 xenograft models. Moreover, the mSiO₂ shell, with its large mesopores, exhibits pH-responsive degradability that enables controlled Fe₃O₄ release in the acidic tumor microenvironment, which in turn improves therapeutic specificity and reduces systemic toxicity. Collectively, these results demonstrate the potential of TiN@mSiO₂-Fe₃O₄/PEI as a highly effective and versatile nanoplatform for advanced cancer nanotherapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123950"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycolysis inhibition-based breakdown of ferroptosis defenses to achieve ferroptosis and immune cascades for antitumor therapy","authors":"Nan Liu ,&nbsp;Xiangling Ren ,&nbsp;Hening Zhuang ,&nbsp;Shimei Li ,&nbsp;Zengzhen Chen ,&nbsp;Longfei Tan ,&nbsp;Changhui Fu ,&nbsp;Qiong Wu ,&nbsp;Yongxiang Zhao ,&nbsp;Xianwei Meng","doi":"10.1016/j.biomaterials.2025.123939","DOIUrl":"10.1016/j.biomaterials.2025.123939","url":null,"abstract":"<div><div>As a newly identified type of regulated cell death, ferroptosis has attracted considerable attention within cancer treatment research. Nevertheless, tumor cells often evade ferroptosis through defensive mechanisms such as aberrant energy metabolism and elevated glutathione (GSH) levels, which help maintain intracellular redox homeostasis. The potential of targeting energy metabolism to disrupt ferroptosis resistance in cancer treatment has been largely overlooked. In this study, we constructed a purposefully engineered nanoplatform utilizing a hollow metal–organic framework as its foundation (ZIF-90), denoted as ZIF-90-ruthenium (Ru)-Apigenin@Tetradecanol-PEG (ZRATP), to disrupt redox balance and establish a tumor microenvironment (TME) conducive to ferroptosis via glycolysis inhibition. Under simultaneous microwave irradiation and acidic TME conditions, ZRATP gradually releases apigenin and Ru. Apigenin acts as a glycolysis inhibitor by targeting pyruvate kinase M2, thereby reprogramming tumor metabolism to favor ferroptosis. Concurrently, Ru depletes GSH and generates reactive oxygen species, directly disturbing redox homeostasis and initiating ferroptosis. This ferroptotic process not only induces immunogenic cell death but also recruits damage-associated molecular patterns. Glycolysis inhibition further alleviates the immunosuppressive TME and enhances immune cell infiltration. These activated immune cells secrete interferon-γ, which downregulates the cystine/glutamate antiporter (system Xc-), thereby further promoting ferroptosis. Together, these effects establish a self-amplifying cycle where metabolic intervention and immune activation synergistically enhance ferroptosis in tumor cells. ZRATP represents a novel strategic platform for the treatment of malignant tumors.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123939"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145838274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duo-nano exosome encapsulating hydrogel boosts wound healing across xenogenic and allogenic models","authors":"Bibi S. Subhan ,&nbsp;Sydney Hanson ,&nbsp;Dianny Almanzar ,&nbsp;Juan F. Cortes Troncoso ,&nbsp;Priya Katyal ,&nbsp;Jonathan W. Sun ,&nbsp;Hao-Wei Shih ,&nbsp;Tamara Mestvirishvili ,&nbsp;Michael Meleties ,&nbsp;Fernando Arias ,&nbsp;Andrew Wang ,&nbsp;Kelly Ruggles ,&nbsp;Igor Dolgalev ,&nbsp;Paolo Mita ,&nbsp;Jin Kim Montclare ,&nbsp;Piul S. Rabbani","doi":"10.1016/j.biomaterials.2025.123975","DOIUrl":"10.1016/j.biomaterials.2025.123975","url":null,"abstract":"<div><div>Chronic wounds, especially in diabetic patients, pose a significant clinical challenge due to impaired microvasculature and delayed healing. This study presents Exo-Q, a novel thermoresponsive hydrogel formed by co-gelation of engineered Q protein nanofibers with exosomes, a class of vesicular intercellular communication mediators. Exo-Q transitions from a gel to a viscoelastic solution at physiological temperature, enabling localized, topical delivery of exosomes with an initial burst release followed by sustained release. In a diabetic mouse wound model, Exo-Q effectively delivered human bone marrow multipotent stromal cell-derived exosomes directly to the wound bed, where they accumulated in endothelial cells of granulation tissue without detectable systemic distribution. Exosomes produced under stringent and replicable cell culture conditions consistently carried biomacromolecular cargo enriched for miRNAs with validated targets in angiogenesis-associated genes, indicative of their therapeutic potential. Topical application of Exo-Q resulted in extensive neovascularized granulation tissue, significantly accelerating wound closure to levels comparable to non-diabetic wounds. Importantly, the hydrogel's modular design maintained the functional integrity of Q protein nanofibers and exosomes, demonstrating compatibility with full-thickness human wounds. This platform allows for tailored customization to address critical stages of diabetic wound healing while ensuring efficacy at low dosages, potentially enabling patient-administered treatment. By leveraging advanced biomaterials, Exo-Q advances the therapeutic efficacy of exosome-based interventions for diabetic wounds, offering a localized, non-invasive solution to chronic, non-healing wounds. This innovative hydrogel platform represents a modular therapeutic strategy with significant potential for clinical applications in regenerative medicine.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123975"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine for venous thrombosis: Insights from an inflammatory perspective","authors":"Qiu Zeng ,&nbsp;Yuan Guo ,&nbsp;Anyu Yang ,&nbsp;Jun Li","doi":"10.1016/j.biomaterials.2025.123910","DOIUrl":"10.1016/j.biomaterials.2025.123910","url":null,"abstract":"<div><div>Venous thrombosis (VT), a serious cardiovascular disease, is commonly encountered across various clinical departments. Over the past decade, the negative role of inflammation in the formation and resolution of VT has become increasingly recognized, with numerous inflammation-related mechanisms in VT being revealed. Despite this understanding, traditional antithrombotic treatments for VT primarily focus on targeting coagulation and fibrinolysis, while inadequately addressing inflammation issues. As a result, these treatments face challenges such as limited efficacy and a high risk of bleeding. Against this backdrop, the versatile characteristics of nanomedicine offer promising solutions for treating VT and its accompanying inflammation issues, particularly in preventing premature drug degradation within circulation and facilitating on-demand drug delivery to disease sites. In addition, recent advances in biomimetic nanotechnology and stimuli-responsive systems have further propelled potential applications of nanomedicine in this area. In this context, this review discusses the rational design of nanomaterials, the optimization of targeted delivery approaches, the advancement of stimuli-responsive release strategies, and the integration of biomimetic nanotechnology, all from an inflammation-focused perspective. With these ongoing advancements, nanomedicine holds great promise for precise and comprehensive VT treatment.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123910"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145831712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fucoidan-based hydrogel with ultrafast self-healing properties for enhanced probiotic delivery to alleviate colitis and microbiota dysbiosis in mice","authors":"Qingquan Liu ,&nbsp;Xinyue Yang ,&nbsp;Xu Zhong ,&nbsp;Wendong Liu ,&nbsp;Jingjing Zhang ,&nbsp;Siyuan Xiang ,&nbsp;Mingqian Tan","doi":"10.1016/j.biomaterials.2026.123984","DOIUrl":"10.1016/j.biomaterials.2026.123984","url":null,"abstract":"<div><div>Fucoidan, a marine-derived polysaccharide with versatile biological functions, holds strong potential for biomedical applications but is limited by low viscosity and poor gelling capacity. To address these challenges, we developed a bioengineered fucoidan-based hydrogel (Fuco-PGA_B) by modulating intermolecular interactions with functionalized polyglutamic acid. This molecular design increased hydrogen-bonding density, yielding a hydrogel with robust rheological properties, including pronounced shear-thinning behavior and instantaneous self-healing. These features enable the material to dissipate peristaltic stress while protecting encapsulated bacteria during gastrointestinal transit. The Fuco-PGA_B hydrogel enabled efficient oral delivery of both Gram-positive (<em>Lactiplantibacillus plantarum</em> 90) and Gram-negative (<em>Escherichia coli</em> Nissle 1917) probiotics. In simulated digestive fluids, probiotic survival increased by more than two orders of magnitude compared to free cells, and <em>in vivo</em> viability was sustained for up to 96 h. Beyond protection, the hydrogel alleviated oxidative stress in intestinal epithelial cells by maintaining glutathione redox balance, inhibiting lipid peroxidation, enhancing superoxide dismutase activity, and scavenging reactive oxygen species. In a mouse colitis model, probiotic-loaded Fuco-PGA_B restored microbial composition by reducing pathogenic species, enriching beneficial taxa, and suppressing inflammation. By integrating the intrinsic properties of fucoidan with a tunable cross-linking strategy, this hydrogel prolongs intestinal retention, enhances probiotic colonization, and improves intervention impact. These findings establish Fuco-PGA_B as a promising oral delivery platform for collaborative intervention in inflammatory bowel disease.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123984"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145922312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-faceted nanodrug reinforcing metalloimmunotherapy for hepatocellular carcinoma","authors":"Yongwei Hu ,&nbsp;Kaiming He ,&nbsp;Mingshen Zhang ,&nbsp;Li Wang ,&nbsp;Lei Lyu ,&nbsp;Desheng Chen ,&nbsp;Kun Li ,&nbsp;Haoyuan Yu ,&nbsp;Zhixing Liang ,&nbsp;Siqi Li ,&nbsp;Peng Jiang ,&nbsp;Guihua Chen ,&nbsp;Wei Liu ,&nbsp;Yanteng Xu ,&nbsp;Linsen Ye ,&nbsp;Yang Yang","doi":"10.1016/j.biomaterials.2025.123899","DOIUrl":"10.1016/j.biomaterials.2025.123899","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) poses a major therapeutic challenge due to its immunosuppressive microenvironment and limited efficacy of current immunotherapies. While immune checkpoint inhibitors (ICIs) improve survival in some patients, their effectiveness is hindered by poor T-cell infiltration and tumor vascular abnormalities. To address this, we investigated the therapeutic potential of combining Lenvatinib with Co²⁺, a strategy aimed at simultaneously targeting PD-L1 expression and activating antitumor immunity. Mechanistic studies revealed that Lenvatinib inhibits MNK1/eIF4E-mediated PD-L1 translation, while Co²⁺ induce ROS-dependent DNA damage and activate the cGAS-STING pathway, triggering immunogenic cell death (ICD) in HCC cells. Building on these findings, we developed pH-modulated self-assembled nanoclusters (Co + Len@OVA) by co-assembling ovalbumin, Lenvatinib, and Co²⁺. These nanoclusters exhibited tumor-selective accumulation and enhanced vascular normalization, which promoted anti-PD1 antibody penetration into tumors. In mouse HCC models, Co + Len@OVA combined with anti-PD1 therapy achieved a significant reduction in tumor volume, significantly outperforming monotherapies. This combination also reshaped the immunosuppressive microenvironment by enhancing DCs’ maturation, increasing cytotoxic CD8⁺ T cells, and suppressing Tregs infiltration. Our study establishes a combinatorial approach that integrates metalloimmunotherapy with vascular modulation, offering a clinically translatable strategy for unresectable HCC.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123899"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombogenic characterization of alloyed and surface-modified magnesium bioresorbable metals for cardiovascular device applications","authors":"Cole A. Baker,&nbsp;Jennifer J. Johnson,&nbsp;Monica T. Hinds,&nbsp;Deirdre E.J. Anderson","doi":"10.1016/j.biomaterials.2025.123935","DOIUrl":"10.1016/j.biomaterials.2025.123935","url":null,"abstract":"<div><div>Magnesium alloys show great promise for use in bioresorbable metal vascular stents due to their mechanical properties. However, considerable material engineering efforts are required to reduce the corrosion rate of magnesium and translate these stents into clinical use. Alloying elements and surface modifications are frequently used to reduce corrosion rate and retain mechanical strength for a longer time. This work sought to characterize the effects that these alloying approaches and surface modifications have on the acute thrombogenicity of magnesium scaffolds. Common magnesium alloys were assessed in conjunction with a biostable clinical control in both <em>ex vivo</em> whole blood and <em>in vitro</em> assays. Our results indicated that magnesium alloying did not affect the thrombogenicity of the material with equivalent platelet deposition and fibrin accumulation on all of the alloyed magnesium metals, as well as in the alloys’ proclivity to produce fibrin or activate factor XII (FXII). In contrast, surface modifications of magnesium, specifically fluorination and anodization, increased platelet deposition and fibrin accumulation onto the magnesium surface compared to the unmodified metal. No differences were found in fibrin or FXIIa generation between surface-modified and the unmodified magnesium material. In conclusion, this research demonstrated that alloying is a viable strategy to increase magnesium corrosion resistance without affecting its thrombogenicity, whereas surface modifications to magnesium may increase the material thrombogenicity.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123935"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-targeting nanotherapy disrupts fungal-bacterial synergy to reprogram inflammatory microenvironments in periodontitis","authors":"Linjia Jian ,&nbsp;Fang Nan ,&nbsp;Yingyue Zhang ,&nbsp;Yuping Jiang ,&nbsp;Min Sun ,&nbsp;Wenke Yang ,&nbsp;Yuxiang Zhu ,&nbsp;Qiang Zhang ,&nbsp;Yuying Li ,&nbsp;Xiao Yan ,&nbsp;Xiao Yuan ,&nbsp;Lu Han ,&nbsp;Yan Wang","doi":"10.1016/j.biomaterials.2025.123923","DOIUrl":"10.1016/j.biomaterials.2025.123923","url":null,"abstract":"<div><div>Conventional anti-biofilm strategies for periodontitis predominantly focus on bacterial populations, often inadvertently facilitating the resurgence of fungi and aggravating the persistence of biofilms. Here, we report a pH-responsive copper-gallic acid core-shell nanoplatform (CGC@HSAF NP) that eradicates drug-resistant fungal-bacterial biofilms through cross-kingdom synergy, marking a significant advancement over traditional species-specific methodologies. The calcium carbonate shell facilitates an acid-triggered release of the antifungal agent HSAF, which selectively disrupts fungal membranes by inhibiting ceramide synthase. This mechanism not only fractures the biofilm scaffolds but also preserves the viability of dental follicle stem cells (113 % viability compared to only 2 % for free HSAF). Such disruption creates penetration channels for bactericidal Cu²⁺ ions, leading to significantly enhanced biofilm removal efficacy compared to monotherapy approaches. Importantly, this dual microbial annihilation effectively halts the metabolic cross-feeding that drives biofilm reformation, thereby addressing the persistent kill-recolonize cycle that plagues existing treatments. Concurrently, gallic acid serves as a potent scavenger of reactive oxygen and nitrogen species and mitigates pro-inflammatory cytokine production, thereby remodeling the pathogenic microenvironment favorably. In a rat model of periodontitis, when delivered via a thermosensitive hydrogel, the CGC@HSAF NPs not only eliminated biofilms but also stimulated alveolar bone regeneration. This work redefines the design of antimicrobial agents by emphasizing the disruption of ecological networks rather than merely targeting isolated species, heralding a novel paradigm in the battle against biofilm-associated infections.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123923"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectionally H2O2-suppliable and antioxidant-consumable copper peroxide nanoparticles for photochemodynamic immunotherapy","authors":"Yanan Zhao ,&nbsp;Ting Li ,&nbsp;Yao Yao ,&nbsp;Shujuan Xue ,&nbsp;Tao Xu ,&nbsp;Shuqi Mi ,&nbsp;Dazhao Li ,&nbsp;Xiaolei Tang ,&nbsp;Feng Zhi ,&nbsp;Dawei Ding ,&nbsp;Huabing Chen","doi":"10.1016/j.biomaterials.2026.123988","DOIUrl":"10.1016/j.biomaterials.2026.123988","url":null,"abstract":"<div><div>Reactive oxygen species (ROS)-based antitumor compounds show great promise in cancer treatments such as chemodynamic therapy (CDT) and photodynamic therapy (PDT), but are severely restricted by both endogenous antioxidants and hydrogen peroxide (H₂O₂). Here, we synthesize bidirectionally H₂O₂-suppliable and antioxidant-consumable copper peroxide (CuO₂) nanoparticles for CDT/PDT-synergized immunotherapy against aggressive triple-negative breast cancers (TNBCs). The CuO₂ nanoparticles are established to afford pH-responsive decomposition into H₂O₂ and Cu²⁺, followed by the reduction into Cu⁺ by glutathione and subsequent catalysis reaction of H₂O₂ into highly reactive ·OH, thus yielding CDT-mediated cell injury. Meanwhile, the glutathione consumption from the nanoparticles attenuates their ROS scavenging to promote singlet oxygen generation of co-assembled indocyanine green upon light exposure, thereby amplifying PDT-based cell damage. Moreover, the dully enhanced CDT/PDT damages of the nanoparticles provoke potent immunogenic cell death that further synergizes with immune checkpoint inhibitor via relieving indoleamine 2,3-dioxygenase 1-mediated immunosuppression, thus amplifying immunotherapeutic efficacy against primary, distant and metastatic TNBCs. This work provides valuable insights into nanomedicines for synergistic cancer therapy.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"329 ","pages":"Article 123988"},"PeriodicalIF":12.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}