Biomaterials最新文献

{"title":"Corrigendum to \"Dual-step irradiation strategy to sequentially destroy singlet oxygen-responsive polymeric micelles and boost photodynamic cancer therapy\" [Biomater. 275 (2021) 120959].","authors":"Kai Deng, Hui Yu, Jia-Mi Li, Kun-Heng Li, Hong-Yang Zhao, Min Ke, Shi-Wen Huang","doi":"10.1016/j.biomaterials.2024.122952","DOIUrl":"10.1016/j.biomaterials.2024.122952","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"122952"},"PeriodicalIF":12.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"A bioprinted and scalable model of human tubulo-interstitial kidney fibrosis\" [Biomaterials, 316 (2025) 123009].","authors":"Daphne Bouwens, Nazanin Kabgani, Cédric Bergerbit, Hyojin Kim, Susanne Ziegler, Sadaf Ijaz, Ali Abdallah, Tamás Haraszti, Sidrah Maryam, Abdolrahman Omidinia-Anarkoli, Laura De Laporte, Sikander Hayat, Jitske Jansen, Rafael Kramann","doi":"10.1016/j.biomaterials.2024.123070","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123070","url":null,"abstract":"","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":" ","pages":"123070"},"PeriodicalIF":12.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogel-integrated exosome mimetics derived from osteogenically induced mesenchymal stem cells in spheroid culture enhance bone regeneration.","authors":"Changlu Xu, Zhi Li, Minjee Kang, Yiqing Chen, Ruoyu Sheng, Tara Aghaloo, Min Lee","doi":"10.1016/j.biomaterials.2025.123088","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123088","url":null,"abstract":"<p><p>Exosomes derived from mesenchymal stem cells (MSCs) offer a promising alternative to traditional cell-based therapies for tissue repair by mitigating risks associated with the transplantation of living cells. However, insufficient osteogenic capacity of exosomes diminishes their potential in bone tissue regeneration. Here, we report novel osteogenically induced exosome mimetics (EMs) integrated into injectable hydrogel carriers for improved bone regeneration. EMs were produced by a serial extrusion of MSCs cultured as spheroids during osteogenic induction. The prepared EMs were chemically anchored on a self-healing hydrogel assembled by guanidinylated hyaluronic acid and silica-rich nanoclays for sustained release of EMs. The administration of hydrogel-integrated EMs into mouse calvarial defects resulted in robust bone tissue regeneration. miRNA sequencing revealed altered expression of specific miRNAs in the EMs related to Wnt/β-catenin and Notch signaling pathways. Our study provides new insights into the development of advanced exosome-based cell-free therapies for bone tissue engineering.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"317 ","pages":"123088"},"PeriodicalIF":12.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LIPUS activated piezoelectric pPLLA/SrSiO₃ composite scaffold promotes osteochondral regeneration through P2RX1 mediated Ca²⁺ signaling pathway.","authors":"Chengxiao Liu, Bin Yu, Zhaowenbin Zhang, Lefeng Su, Ruiqing Wang, Yu Jin, Weiming Guo, Ruomei Li, Zhen Zeng, Peng Mei, Jiang Chang, Lunguo Xia, Chen Yang, Bing Fang","doi":"10.1016/j.biomaterials.2025.123084","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2025.123084","url":null,"abstract":"<p><p>Addressing the concurrent repair of cartilage and subchondral bone presents a significant challenge yet is crucial for the effective treatment of severe joint injuries. This study introduces a novel biodegradable composite scaffold, integrating piezoelectric poly-l-lactic acid (pPLLA) with strontium-enriched silicate bioceramic (SrSiO₃). This innovative scaffold continually releases bioactive Sr²⁺ and SiO₃^2- ions while generating an electrical charge under low-intensity pulsed ultrasound (LIPUS) stimulation, a clinically recognized method. The scaffold's unique dual action, emanating both chemical and electrical signals, activates the purinergic receptor P2X 1 (P2RX1) calcium ion channel, promoting an influx of intracellular calcium ions. This process results in a synergistic enhancement of both chondrogenic activities of rat chondrocytes (rCCs) and osteogenic activities of rat bone marrow mesenchymal stem cells (rBMSCs). Furthermore, the scaffold's effectiveness in integrating articular cartilage and subchondral bone repair is confirmed in a rat model of joint osteochondral injury. This study thereby offers a groundbreaking approach for treating severe osteoarticular cartilage defects.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"317 ","pages":"123084"},"PeriodicalIF":12.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ellagic acid-protein nano-complex inhibits tumor growth by reducing the intratumor bacteria and inhibiting histamine production.","authors":"Bingbing Wu, Chenlu Yao, Heng Wang, Huaxing Dai, Bo Tian, Dongxiao Li, Jialu Xu, Haibo Cheng, Fang Xu, Dongdong Sun, Chao Wang","doi":"10.1016/j.biomaterials.2024.123078","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123078","url":null,"abstract":"<p><p>In recent years, there has been growing interest in understanding the role of bacteria within tumors and their potential as targets for cancer therapy. In this work, we developed an ellagic acid (EA) - endogenous protein (eP) nanocomposite (eP-EA) to target tumors by EPR (enhanced permeability and retention), kill bacteria within tumors to regulate anti-tumor immune responses. The potential mechanism of eP-EA treatment is associated with the reduced abundance and diversity of microorganisms within the tumor, culminating with an altered metabolism within the Tumor microenvironment (TME). Among them, the metabolite histamine that contributes to tumor progression, is significantly reduced in the TME after eP-EA treatment. We show that one possible mechanism by which these microbes promote tumor growth is through the production of histamine. This work suggests that the ellagic acid (EA)-protein nano complex can enhance cancer immunotherapy by targeting the intratumoral bacteria and reduce their production of histamine, delineating the potential relationship between intratumor bacteria and their impact on tumors. Our work suggests that the EA-protein nano complex can enhance cancer immunotherapy by targeting the intratumoral bacteria, suggesting the role of bacterial metabolites in contributing to tumor progression.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"317 ","pages":"123078"},"PeriodicalIF":12.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of PVA/OHA-Gs@PTMC/PHA double-layer nanofiber flexible scaffold with antibacterial function for tension free rectal in-situ reconstruction.","authors":"Bingxu Zhang, Xujian Li, Chuan Jiang, Chuanguang Wang, Haifeng Que, Cheng Zheng, Zhixiao Ji, Xudong Tao, Hongtao Xu, Changcan Shi","doi":"10.1016/j.biomaterials.2024.123064","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123064","url":null,"abstract":"<p><p>The effective prevention and treatment of anastomotic leakage after intestinal anastomosis for colorectal diseases is still a major clinical challenge. In order to assist intestinal anastomosis healing and avoid anastomotic leakage caused by high tension, low blood supply or infection, we designed a double-layer nanofiber intestinal anastomosis scaffold, which was composed of electrospun PTMC/PHA nanofibers as the main layer, and electrospun PVA/OHA-Gs nanofibers with antibacterial properties as the antibacterial surface layer. This double-layer scaffold has good toughness, its maximum tensile force value could reach 8 N, elongation could reach 400 %, and it has hydrophilic properties, and its contact angle was about 60°. On the basis of reducing anastomotic tension and isolating intestinal contents, this double-layer nanofiber anastomotic scaffold not only played an antibacterial effect in the short term after surgery to reduce inflammatory response, but also had the characteristics of multiple three-dimensional network structure like extracellular matrix which could promote tissue healing. The PVA/OHA-Gs@PTMC/PHA scaffold was implanted into a rabbit model simulating mechanical intestinal obstruction, and the results showed that the nanofibers of the scaffold could be degraded in vivo while maintaining a certain stability, that is, the overall structure of the PVA/OHA-Gs@PTMC/PHA scaffold would not shrink and deform due to degradation in a certain period of time. Therefore, the treatment with this scaffold showed better healing at the anastomotic site. Compared to the direct anastomosis group and pure PTMC scaffold group, the double-layer scaffold group promoted a faster return to normal anastomotic strength within 7 days. This PVA/OHA-Gs@PTMC/PHA double-layer nanofiber flexible scaffold appears to be a promising therapeutic strategy to prevent anastomotic leakage after intestinal anastomosis.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"317 ","pages":"123064"},"PeriodicalIF":12.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroactive membranes enhance in-situ alveolar ridge preservation via spatiotemporal electrical modulation of cell motility.","authors":"Yanlan Wang, Shiqi Zhou, Xiaoshuang Wang, Dongheng Lu, Jinghong Yang, Yu Lu, Xiaolei Fan, Changhao Li, Yan Wang","doi":"10.1016/j.biomaterials.2024.123077","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123077","url":null,"abstract":"<p><p>Post-extraction alveolar bone resorption invariably compromises implant placement and aesthetic restoration outcomes. Current non-resorbable membranes exhibit limited efficacy in alveolar ridge preservation (ARP) due to insufficient cell recruitment and osteoinductive capabilities. Herein, we introduce a multifunctional electroactive membrane (PPy-BTO/P(VDF-TrFE), PB/PT) designed to spatiotemporally regulate cell migration and osteogenesis, harmonizing with the socket healing process. Initially, the membrane's endogenous-level surface potential recruits stem cells from the socket. Subsequently, adherent cell-migration-triggered forces generate on-demand piezopotential, stimulating intracellular calcium ion fluctuations and activating the Ca²⁺/calcineurin/NFAT1 signaling pathway via Cav3.2 channels. This enhances cell motility and osteogenic differentiation predominantly in the coronal socket region, counteracting the natural healing trajectory. The membrane's self-powered energy supply, proportional to cell migration velocity and manifested as nanoparticle deformation, mitigates ridge shrinkage, both independently and in conjunction with bone grafts. This energy-autonomous membrane, based on the spatiotemporal modulation of cell motility, presents a novel approach for in-situ ARP treatment and the development of 4D bionic scaffolds.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"317 ","pages":"123077"},"PeriodicalIF":12.8,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting m⁶A demethylase FTO to heal diabetic wounds with ROS-scavenging nanocolloidal hydrogels.","authors":"Xinyao Zheng, Shaohui Deng, Yuan Li, Zhipeng Luo, Ziqi Gan, Zhaoping Zheng, Rui Xu, Shan Xiao, Yuxiong Cai, Jianfu Meng, Li Li, Changxing Li, Xiaowen Xue, Wei Dai, Si Qin, Mengying Wang, Kang Zeng, Zecong Xiao, Laixin Xia","doi":"10.1016/j.biomaterials.2024.123065","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123065","url":null,"abstract":"<p><p>Chronic diabetic wounds are a prevalent and severe complication of diabetes, contributing to higher rates of limb amputations and mortality. N6-methyladenosine (m⁶A) is a common RNA modification that has been shown to regulate tissue repair and regeneration. However, whether targeting m⁶A could effectively improve chronic diabetic wound healing remains largely unknown. Here, we found a significant reduction in mRNA m⁶A methylation levels within human diabetic foot ulcers, and the expression level of fat mass and obesity-associated protein (FTO) was significantly increased. We identified that m⁶A modifies the RNA of matrix Metalloproteinase 9 (MMP9), a key factor in diabetic wound healing, to regulate its expression. Importantly, we developed a ROS-scavenging nanocolloidal hydrogel loaded with an FTO inhibitor to increase the m⁶A level of MMP9 RNA in wounds. The hydrogel can effectively accelerate wound healing and skin appendage regeneration in streptozotocin-induced type I diabetic rats at day 14 (approximately 98 % compared to 76.98 % in the control group) and type II diabetic db/db mice at day 20 (approximately 93 % compared to 60 % in the control group). Overall, our findings indicate that targeting m⁶A with ROS-scavenging hydrogel loaded with FTO inhibitor may be an effective therapeutic strategy for diabetic wound healing.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"317 ","pages":"123065"},"PeriodicalIF":12.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental dynamics mimicking inversely engineered pericellular matrix for articular cartilage regeneration.","authors":"Yongkang Yang, Ziheng Xu, Songlin He, Chao Wang, Runmeng Li, Ruiyang Zhang, Jianwei Li, Zhen Yang, Hao Li, Shuyun Liu, Quanyi Guo","doi":"10.1016/j.biomaterials.2024.123066","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123066","url":null,"abstract":"<p><p>The mechanical mismatch of scaffold matrix-mesenchymal stem cells (MSCs) has been a longstanding issue in the clinical application of MSC-based therapy for articular cartilage (AC) regeneration. Existing tissue-engineered scaffolds underestimate the importance of the natural chondrocyte pericellular matrix (PCM). Here, we reveal the temporal and spatial characteristics of collagen distribution around the chondrocytes. Next, we demonstrate a rationally designed layer-by-layer single-cell encapsulation system which can mimic PCM mechanical responses and enhance MSC chondrogenesis via reestablished the mechanical coupling of PCM-like primitive matrix and chondrocytes. This successfully simulates the temporal and spatial characteristics of collagen secretion. Through investigation of the micromechanical environment of the cells and full-atom simulation analysis of TRPV4, we determine the specific mechanisms by which cellular mechanical forces near the cell are converted into biological signals. The TRPV4-YAP/TAZ-PI3K-Akt signaling pathway is involved in MSC cartilage formation through a joint analysis of the mRNA sequencing and spatial transcriptome results. In a rat model of articular cartilage defects, our inversely engineered pericellular matrix-encapsulated MSC-loaded scaffolds show regenerative performance that are superior to those of scaffolds loaded with only MSCs. These results demonstrate the feasibility of using a PCM-mimicking system to improve MSC chondrogenesis and the efficacy of AC repair.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"317 ","pages":"123066"},"PeriodicalIF":12.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multifunctional mitochondria-protective gene delivery platform promote intervertebral disc regeneration.","authors":"Yu Wang, Mingyan Deng, Ye Wu, Cheng Zheng, Fanjun Zhang, Chuan Guo, Bo Zhang, Cheng Hu, Qingquan Kong, Yunbing Wang","doi":"10.1016/j.biomaterials.2024.123067","DOIUrl":"https://doi.org/10.1016/j.biomaterials.2024.123067","url":null,"abstract":"<p><p>Intervertebral disc degeneration (IDD) is a deleterious condition driven by localized inflammation and the associated disruption of the normal homeostatic balance between anabolism and catabolism, contributing to progressive functional abnormalities within the nucleus pulposus (NP). Despite our prior evidence demonstrating that a miR-21 inhibitor can have regenerative effects that counteract the progression of IDD, its application for IDD treatment remains limited by the inadequacy of current local delivery systems. Here, an injectable tannic acid (TA)-loaded hydrogel gene delivery system was developed and used for the encapsulation of a multifunctional mitochondria-protecting gene nanocarrier (PHs). This engineered platform was designed for the sustained on-demand delivery of both miR-21 inhibitor and ss-31 (mitochondrial-targeted peptide) constructs to the NP. This prepared hydrogel could be implanted into the intervertebral disc using a minimally invasive approach whereupon it was able to rapidly release TA. Sustained PHs release was then achieved as appropriate through a mechanism mediated by the activity of MMP-2. Following the targeted uptake of PHs by degenerated NP cells, the subsequent release of encapsulated miR-21 inhibitor suppressed apoptotic cell death and modulated the metabolism of the extracellular matrix (ECM) by targeting the Spry1 gene. At the same time, ss-31 was able to target damaged mitochondria and alleviate inflammatory activity via the suppression of mitochondrial ROS-NLRP3-IL-1β/Caspase1 pathway activity. Synergistic ECM regeneration and anti-inflammatory effects were sufficient to provide therapeutic benefits in an in vivo model of IDD. Together, these results thus highlight this hydrogel-based gene delivery platform as a promising novel approach to the treatment of IDD.</p>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"317 ","pages":"123067"},"PeriodicalIF":12.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}