一种具有机械活性和生物活性的非均质水凝胶贴片用于慢性糖尿病伤口愈合

IF 12.9 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Suyang Dai , Lingchen Mao , Xiongwei Chen , Jie Zhang , Xin Li , Maosheng Zhang , Ni Jiang , Keda Yang , Shun Duan , Zhihua Gan , Zhenbo Ning
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引用次数: 0

摘要

慢性伤口是糖尿病患者常见的并发症,其特点是由于炎症反应持续过度、易感染、糖尿病创面缺乏有效的收缩应激而难以愈合。在本研究中,我们在多孔聚氨酯泡沫(DDLPU-foam)中,在改性海藻酸盐(Alg-Cat)存在的情况下,通过丙烯酰胺(AM)的原位自由基聚合,开发了一种非均相水凝胶贴片。具有光热性能的去甲基化脱碱木素- fe3 +复合物结构(DDL-Fe3+)的聚氨酯泡沫使贴片具有优异的近红外(NIR)光响应形状记忆性能,使预拉伸贴片在近红外光下为糖尿病伤口提供双轴收缩,同时还具有广谱光热抗菌性能。水凝胶相的Alg-Cat含有二硫化物连接的儿茶酚,具有抗氧化活性和灵活的组织粘附性。体内实验表明,DDLPU/Alg-Cat贴片通过机械调节功能和抗氧化活性的结合,有效降低慢性创面炎症水平,促进组织重建,加速创面愈合。该异质水凝胶贴片具有机械调节功能和生物活性,为治疗慢性糖尿病创面提供了一种新颖有效的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A heterogeneous hydrogel patch with mechanical activity and bioactivity for chronic diabetic wound healing

A heterogeneous hydrogel patch with mechanical activity and bioactivity for chronic diabetic wound healing
Chronic wounds are common complications for diabetic patients, characterized by difficult healing because of the persistent and excessive inflammatory response, susceptibility to infection, and a lack of effective contraction stress at the diabetic wound site. In this study, we develop a heterogeneous hydrogel patch through the in situ free radical polymerization of acrylamide (AM) in the presence of modified alginate (Alg-Cat) within a porous polyurethane foam (DDLPU-foam). The polyurethane foam containing demethylated dealkaline lignin-Fe3+ complex structures (DDL-Fe3+) with photothermal properties endows the patches with excellent near-infrared (NIR) light-responsive shape memory performance, allowing the pre-stretched patches to provide biaxial contraction for diabetic wounds under NIR light, while also providing broad-spectrum photothermal antibacterial properties. The Alg-Cat in the hydrogel phase contains disulfide-linked catechol, offering antioxidant activity and flexible tissue adhesion. In vivo tests demonstrate that the DDLPU/Alg-Cat patch effectively reduces the inflammation level of chronic wound and promote tissue reconstruction, accelerating wound healing through combined mechanical modulation function and antioxidant activity. This heterogeneous hydrogel patch possesses both mechanical modulation function and bioactivity, providing a novel and effective strategy for treating chronic diabetic wounds.
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来源期刊
Biomaterials
Biomaterials 工程技术-材料科学:生物材料
CiteScore
26.00
自引率
2.90%
发文量
565
审稿时长
46 days
期刊介绍: Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.
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