Suyang Dai , Lingchen Mao , Xiongwei Chen , Jie Zhang , Xin Li , Maosheng Zhang , Ni Jiang , Keda Yang , Shun Duan , Zhihua Gan , Zhenbo Ning
{"title":"一种具有机械活性和生物活性的非均质水凝胶贴片用于慢性糖尿病伤口愈合","authors":"Suyang Dai , Lingchen Mao , Xiongwei Chen , Jie Zhang , Xin Li , Maosheng Zhang , Ni Jiang , Keda Yang , Shun Duan , Zhihua Gan , Zhenbo Ning","doi":"10.1016/j.biomaterials.2025.123531","DOIUrl":null,"url":null,"abstract":"<div><div>Chronic wounds are common complications for diabetic patients, characterized by difficult healing because of the persistent and excessive inflammatory response, susceptibility to infection, and a lack of effective contraction stress at the diabetic wound site. In this study, we develop a heterogeneous hydrogel patch through the in situ free radical polymerization of acrylamide (AM) in the presence of modified alginate (Alg-Cat) within a porous polyurethane foam (DDLPU-foam). The polyurethane foam containing demethylated dealkaline lignin-Fe<sup>3+</sup> complex structures (DDL-Fe<sup>3+</sup>) with photothermal properties endows the patches with excellent near-infrared (NIR) light-responsive shape memory performance, allowing the pre-stretched patches to provide biaxial contraction for diabetic wounds under NIR light, while also providing broad-spectrum photothermal antibacterial properties. The Alg-Cat in the hydrogel phase contains disulfide-linked catechol, offering antioxidant activity and flexible tissue adhesion. In vivo tests demonstrate that the DDLPU/Alg-Cat patch effectively reduces the inflammation level of chronic wound and promote tissue reconstruction, accelerating wound healing through combined mechanical modulation function and antioxidant activity. This heterogeneous hydrogel patch possesses both mechanical modulation function and bioactivity, providing a novel and effective strategy for treating chronic diabetic wounds.</div></div>","PeriodicalId":254,"journal":{"name":"Biomaterials","volume":"324 ","pages":"Article 123531"},"PeriodicalIF":12.9000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A heterogeneous hydrogel patch with mechanical activity and bioactivity for chronic diabetic wound healing\",\"authors\":\"Suyang Dai , Lingchen Mao , Xiongwei Chen , Jie Zhang , Xin Li , Maosheng Zhang , Ni Jiang , Keda Yang , Shun Duan , Zhihua Gan , Zhenbo Ning\",\"doi\":\"10.1016/j.biomaterials.2025.123531\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Chronic wounds are common complications for diabetic patients, characterized by difficult healing because of the persistent and excessive inflammatory response, susceptibility to infection, and a lack of effective contraction stress at the diabetic wound site. In this study, we develop a heterogeneous hydrogel patch through the in situ free radical polymerization of acrylamide (AM) in the presence of modified alginate (Alg-Cat) within a porous polyurethane foam (DDLPU-foam). The polyurethane foam containing demethylated dealkaline lignin-Fe<sup>3+</sup> complex structures (DDL-Fe<sup>3+</sup>) with photothermal properties endows the patches with excellent near-infrared (NIR) light-responsive shape memory performance, allowing the pre-stretched patches to provide biaxial contraction for diabetic wounds under NIR light, while also providing broad-spectrum photothermal antibacterial properties. The Alg-Cat in the hydrogel phase contains disulfide-linked catechol, offering antioxidant activity and flexible tissue adhesion. In vivo tests demonstrate that the DDLPU/Alg-Cat patch effectively reduces the inflammation level of chronic wound and promote tissue reconstruction, accelerating wound healing through combined mechanical modulation function and antioxidant activity. This heterogeneous hydrogel patch possesses both mechanical modulation function and bioactivity, providing a novel and effective strategy for treating chronic diabetic wounds.</div></div>\",\"PeriodicalId\":254,\"journal\":{\"name\":\"Biomaterials\",\"volume\":\"324 \",\"pages\":\"Article 123531\"},\"PeriodicalIF\":12.9000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomaterials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0142961225004508\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomaterials","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0142961225004508","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
A heterogeneous hydrogel patch with mechanical activity and bioactivity for chronic diabetic wound healing
Chronic wounds are common complications for diabetic patients, characterized by difficult healing because of the persistent and excessive inflammatory response, susceptibility to infection, and a lack of effective contraction stress at the diabetic wound site. In this study, we develop a heterogeneous hydrogel patch through the in situ free radical polymerization of acrylamide (AM) in the presence of modified alginate (Alg-Cat) within a porous polyurethane foam (DDLPU-foam). The polyurethane foam containing demethylated dealkaline lignin-Fe3+ complex structures (DDL-Fe3+) with photothermal properties endows the patches with excellent near-infrared (NIR) light-responsive shape memory performance, allowing the pre-stretched patches to provide biaxial contraction for diabetic wounds under NIR light, while also providing broad-spectrum photothermal antibacterial properties. The Alg-Cat in the hydrogel phase contains disulfide-linked catechol, offering antioxidant activity and flexible tissue adhesion. In vivo tests demonstrate that the DDLPU/Alg-Cat patch effectively reduces the inflammation level of chronic wound and promote tissue reconstruction, accelerating wound healing through combined mechanical modulation function and antioxidant activity. This heterogeneous hydrogel patch possesses both mechanical modulation function and bioactivity, providing a novel and effective strategy for treating chronic diabetic wounds.
期刊介绍:
Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.