Separation and Purification Technology最新文献

{"title":"Extraction of germanium and fixation of arsenic from lignite using pyrolysis","authors":"Shiqi Dai, Mingjun Liu, Fengshuai Sun, Ao Li, Yaowen Xing, Xiahui Gui","doi":"10.1016/j.seppur.2025.134054","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.134054","url":null,"abstract":"The one-step reduction combustion volatilization method of Ge-bearing lignite is the primary technique for extracting germanium (Ge). However, this method generates large amounts of industrial waste, such as fly ash, and releases significant quantities of arsenic (As). This study proposed a pyrolysis method that extracts Ge from lignite while simultaneously immobilizing As. Firstly, by investigating the migration and transformation processes of Ge and As during pyrolysis, it was found that the transformation of aluminosilicates into oxides was the key controlling step for Ge and As volatilization. The addition of carbon sources effectively enhanced Ge volatilization, among which metallurgical coke and coking coal also played roles in As immobilization. The results showed that 1100 °C was a key temperature for Ge volatilization. Under the conditions of a heating temperature of 1100 °C, heating time of 30 min, and 50 % metallurgical coke addition, the Ge volatilization rate reached 84.71 %, while the As volatilization rate was only 9.36 %, increasing the Ge/As ratio from 1.50 to 9.05. Meanwhile, the performance of metallurgical coke remained stable after five cycles of reuse, with a recovery rate of 97.48 %. Finally, the potential mechanisms for Ge volatilization and As fixation during pyrolysis were proposed. This method avoided the generation of large amounts of fly ash and the emission of As associated with traditional processes. It showed potential for improving the separation of Ge and As during subsequent chlorination distillation, providing a novel and environmentally friendly approach for the extraction of germanium from lignite.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"38 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen-vacancy-rich N-doped NiFe2O4 activates peroxymonosulfate for efficient water purification","authors":"Donglei Fu, Zhengxiong Zhao, Pengwei Yan, Zhonglin Chen, Jinxiang Zuo","doi":"10.1016/j.seppur.2025.134061","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.134061","url":null,"abstract":"An efficient catalyst with abundant oxygen vacancies (OVs) was obtained via nitrogen (N) doping NiFe₂O₄ for peroxymonosulfate (PMS) activation to achieve durable water purification. The N-NiFe₂O₄ activated process enhanced the formation of SO₄^{<img alt=\"radical dot\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/rad.gif\" style=\"vertical-align:middle\"/>−} and ·OH, thus endowing the system with high decontamination performance compared to pristine NiFe₂O₄. The influence of complex aquatic matrices on the N-NiFe₂O₄/PMS system towards 2,4-dichlorophenoxyacetic acid (2,4-D) removal was investigated in detail. The systematic evaluation revealed that the 5.0 % N-doped NiFe₂O₄/PMS system demonstrated optimal catalytic activity, achieving an 86.9 % removal efficiency of 2,4-D within 15 min. Radical quenching experiments identified SO₄^{<img alt=\"radical dot\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/rad.gif\" style=\"vertical-align:middle\"/>−} and ·OH were predominantly responsible for 2,4-D degradation. According to the in situ tests and Density functional theory (DFT) calculation, the constructed OVs on N-NiFe₂O₄ greatly promoted the adsorption of PMS, and next served as reactive sites for electron transfer via the Fe³⁺ or Ni²⁺ sites, which further activated PMS for the formation of SO₄^{<img alt=\"radical dot\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/rad.gif\" style=\"vertical-align:middle\"/>−}. In short, this work gives an effective strategy to prepare high-performance catalysts for durable water purification system construction.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"12 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of waste ferrous sulfate for recovering valuable metal elements from minerals and industrial solid waste: A waste to wealth strategy","authors":"Minyu He, Jinping Shuai, Haoyan Li, Lanjie Li, Qingcai Liu, Weizao Liu","doi":"10.1016/j.seppur.2025.134058","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.134058","url":null,"abstract":"The global transition to clean energy, driven by electric vehicles and battery storage, will lead to a rapid increase in the demand for metal resources. Promoting the efficient recovery and recycling of low-grade ores, tailings, and industrial solid waste is not only an inevitable choice to address the shortage of metal resources but also a key strategy to reduce environmental risks and promote sustainable development. Traditional pyrometallurgical and hydrometallurgical methods have several drawbacks, including high energy consumption, the generation of secondary pollutant gases, long process flows, equipment vulnerability to corrosion, and the production of acidic wastewater. The waste ferrous sulfate roasting method, as an emerging process for the treatment of minerals and solid waste, offers unique advantages in the circular economy model of “waste-treat-waste.” With its high metal recovery efficiency, significant environmental friendliness, and low energy consumption and cost, it stands out as an efficient and sustainable solution. However, its widespread adoption has been severely hindered due to the lack of comprehensive and systematic understanding. This paper first summarizes waste ferrous sulfate roasting on recovering valuable metals from various minerals and industrial solid waste. The sulfation roasting mechanisms are discussed accordingly. The future development of this emerging technology lies in enhancing sulfur utilization, controlling sulfur-containing gas emissions, and further expanding its industrial applications. The research and review of this technology offer new approaches for the effective treatment of low-grade mineral resources, tailings, and industrial solid waste, making it of significant importance for resource recycling in society.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"196 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The stability mechanism of CO catalytic oxidation over Ru/TiO2 in the presence of SO2 and H2O","authors":"Xinglong Gu, Zijun Gong, Quanlong Li, Zheng Huang, Shihao Li, Dong Zhang, Changming Li, Jianling Li, Zhaohui Chen, Jian Yu","doi":"10.1016/j.seppur.2025.134051","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.134051","url":null,"abstract":"Developing catalysts suitable for applications in industrial flue gas and capable of stably removing CO remains a major challenge, primarily due to catalyst deactivation in the presence of SO₂ and H₂O. This study found that the Ru/TiO₂ catalyst can remain stable for CO oxidation in the presence of SO₂ and H₂O under certain conditions (e.g., high CO concentrations, high temperatures) even though its CO oxidation activity decays at the initial stage. The multiple structural characterizations identified the increased ratio of Ru³⁺/Ru^δ+ and Ti⁴⁺/Ti³⁺ as well as notable surface sulfur species in the used Ru/TiO₂, which confirms the partial sulfation of Ru/TiO₂ after use. Particularly, TPR and <em>in situ</em> DRIFTS results indicate that sulfate is uniformly and easily reduced at central reduction temperatures above 250 °C. In addition, a series of DRIFTS tests further confirmed that the presence of high concentrations of CO significantly inhibited sulfate formation. CO oxidation proceeded through the generation of key intermediates such as carbonates and formates. Moreover, the presence of H₂O promoted the *OH-mediated pathway, facilitating the formation of HCOO* species and thereby suppressing further sulfate accumulation. All these structure and reaction data demonstrate that a dynamic depositional-decomposition equilibrium of surface sulfur species exists for the CO oxidation over the Ru/TiO₂ catalyst on certain conditions such as high CO concentration, elevated temperature, or low SO₂ concentration, accounting for the observed activity decay at the initial stage but subsequent durability and stability for the long-term performance test in the presence of SO₂ and H₂O. The revealed unique stability mechanism of CO catalytic oxidation over noble metal catalysts will shed light on the development of efficient and stable noble metal catalysts and accelerate their engineering application for the purification of CO from flue gas in industry.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"45 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing freeze desalination via stirring-induced modulation of thermal and solute transport at the ice-liquid interface","authors":"Hongtao Zhang, Khadije El Kadi, Isam Janajreh","doi":"10.1016/j.seppur.2025.134059","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.134059","url":null,"abstract":"Optimizing crystallization dynamics and solute separation in freeze desalination (FD) remains challenging due to non-uniform thermal gradients and complex fluid behavior. This study investigates the effect of mechanical stirring on FD performance using a custom-designed, jacketed cylindrical crystallizer. A synthetic NaCl solution (35 g/L) was subjected to radial directional freezing under varied stirring conditions to evaluate changes in desalination efficiency. Experimental measurements of brine temperature and ice salinity were complemented by a validated computational fluid dynamics (CFD) model simulating thermal and solute transport during freezing. The model captured key trends observed experimentally, including ice growth patterns and salinity evolution, with minor deviations attributed to heat losses. Initially, ice nucleated along the cooled wall, driven by the imposed radial temperature gradient. Over time, salt rejection increased brine density, inducing buoyancy-driven stratification and shifting ice accumulation toward the top of the crystallizer, where salinity was lower. Stirring disrupted these gradients, homogenizing temperature and concentration fields. Sensitivity analysis revealed that stirring at 60 rpm improved salt removal efficiency to 67 %, compared to 59 % under static conditions, without reducing ice yield. Stirring moderated thermal and solutal boundary layers, delayed salinity buildup at the ice–liquid interface, and promoted more uniform crystal growth. These findings demonstrate that mechanical stirring can be used strategically to enhance desalination performance of FD technology. The insights gained offer guidance for optimizing FD systems through informed control of hydrodynamics and crystallization behavior, contributing to the development of energy-efficient separation technologies for sustainable water resource management.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"100 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance evaluation and optimization of pharmaceutical removal with sulfate radical-based photooxidation processes by machine learning algorithms","authors":"Narmin Garazade, Emine Can-Güven, Fatih Güven, Senem Yazici Guvenc, Gamze Varank","doi":"10.1016/j.seppur.2025.134047","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.134047","url":null,"abstract":"The aim of this study was to evaluate the efficiency of sulfate radical-based photooxidation using machine learning algorithms in the removal of metformin (METF), one of the most widely used pharmaceuticals in the world. UVC lamps were used in photochemical oxidation processes, and peroxydisulfate (PS) and peroxymonosulfate (PMS) were added as oxidants. The effects of UV-based process variables (initial pH, PS/PMS dose, initial METF concentration) on METF removal and the optimum conditions were determined. Under optimum conditions, the effect of inorganic anions, dominant radical species, and unit energy consumption (EE/O) was determined. The removal efficiencies of METF were 53.9 % and 58.3 % for the UV/PS and UV/PMS processes, respectively, under optimum conditions (4 mM PS dose and pH 7 for the UV/PS process; 8 mM PMS dose and pH 9 for the UV/PMS process). For both processes, nitrate decreased the METF removal rate while sulfate and phosphate were ineffective. The effect of bicarbonate and chloride was positive in the UV/PMS process and negative in the UV/PS process. Based on contribution rates, the dominant radical types were sulfate and hydroxyl radicals in the UV/PS and UV/PMS processes, respectively. EE/O values were determined as 1.19 and 1.05 kWh/L for the UV/PS and UV/PMS processes, respectively. METF removal was effectively modeled using machine learning algorithms, yielding high R² values and low MAE and RMSE levels. XGBoost models performed well, with no overfitting and successful generalization.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"528 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A durable pipette tip-solid-phase extraction based on dually enhanced CNTs-PAN@UiO-66-NH2 nanofiber membrane for rapid extraction of polychlorinated biphenyls","authors":"Xuemei Wang ,&nbsp;Fu Mu ,&nbsp;Jiyun Chen ,&nbsp;Jingwei Liu ,&nbsp;Rao Peng ,&nbsp;Xinzhen Du ,&nbsp;Xiaoquan Lu","doi":"10.1016/j.seppur.2025.134046","DOIUrl":"10.1016/j.seppur.2025.134046","url":null,"abstract":"<div><div>Monitoring concentration and evaluate of the exposure risk of polychlorinated biphenyls (PCBs) has been a significant Population health concern for many years. However, this task remains challenging due to the high lipophilicity and extremely low concentrations of PCBs. In this study, a durable pipette tip-solid phase extraction (PT-SPE) was proposed based on carboxylated carbon nanotubes (COOH-CNTs)-and poly acrylonitrile (PAN)@UiO-66-NH₂ dually enhanced nanofiber membrane (CNTs-PAN@UiO-66-NH₂) for reaching rapid extraction and precise detection of PCBs prior to high-performance liquid chromatography-ultraviolet (HPLC-UV). The constructed nanofiber membrane (NFM) had outstanding mechanical strength and plentiful adsorption sites due to the incorporation of COOH-CNTs and UiO-66-NH₂. A systematic optimization of critical PT-SPE parameters resulted in the successful extraction of five PCBs within 17 min in real water and food samples. Under optimized conditions, the limits of detection (LODs, S/N = 3) and quantification (LOQs, S/N = 10) were determined to be in the ranges of 0.008–0.241 μg⋅L⁻¹ and 0.027–0.803 μg⋅L⁻¹ for the five PCBs, respectively. Additionally, density functional theory (DFT) calculations of adsorption energy confirmed that the introduction of halogen bonding played a pivotal role in realizing the high extraction capacity of CNTs-PAN@UiO-66-NH₂ NFM for PCBs. The developed method offered the superiorities of rapid analysis and high sensitivity, making it be well-suited for the ultra-trace determination of PCBs.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"376 ","pages":"Article 134046"},"PeriodicalIF":8.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on heavy metal wastewater treatment in the integrated circuit industry: From pollution control to resource utilization","authors":"Rong Wang, Zhipeng Tang, Chenyang Zhang, Wei Sun, Zhuo Chen, Xin Wei, Mengqi Liu","doi":"10.1016/j.seppur.2025.134033","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.134033","url":null,"abstract":"The integrated circuit (IC) industry is a strategic emerging sector that plays a significant role in global technological advancement. However, its development has also led to the generation of substantial amounts of heavy metal wastewater. Currently, the hazardous wastewater from the IC industry primarily employs a centralized treatment model characterized by “unidirectional direct current and end-of-pipe treatment,” which emphasizes meeting discharge standards while neglecting resource recovery. This approach presents several challenges, including lengthy processes, high costs, large volumes of sludge, and elevated risks of secondary pollution. This paper systematically reviews recent progress in IC heavy metal wastewater treatment technologies, analyzing their fundamental principles, key advantages, and persistent limitations. It proposes a novel resource utilization strategy: “wastewater classification treatment and differentiated utilization.” This paradigm shift enables flexible, scenario-specific adaptation based on water quality characteristics, moving beyond mere pollution control. The discussion further explores future pathways for implementing deep resource recovery within the IC sector. The analysis herein aims to provide theoretical insights and methodological frameworks for sustainable heavy metal wastewater management in the IC industry. This paper underscores that advanced resource recovery is indispensable for the sector’s environmentally sustainable development, offering new perspectives to overcome critical environmental bottlenecks constraining IC industry progress.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"24 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrahigh-capacity adsorption of Rhodamine B by N, S co-doped carbon nanotube composites derived from coal","authors":"Chuanfang Zhang, Ying Wang, Yuqiong Zhao, Guojie Zhang","doi":"10.1016/j.seppur.2025.134045","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.134045","url":null,"abstract":"The release of organic dyes into the environment poses a significant threat to ecosystems and human health, making it necessary to develop efficient and economical dye removal technologies. Among the various treatment methods, adsorption is highly promising due to its simple operation and low operating cost. However, traditional adsorbents often face limitations such as low adsorption capacity and poor selectivity. In this study, N,S co-doped carbon nanotube composites (SCTNs/AC) were successfully synthesized using coal as the precursor, potassium carbonate as the activator, and thiourea as the nitrogen and sulfur source. The SCTNs/AC demonstrated outstanding adsorption performance for rhodamine B (Rh B). Experimental results revealed that SCTNs/AC removed 99.34 % of a 300 mg/L Rh B solution within 20 min at 323 K. After four consecutive adsorption–desorption cycles using ethanol as the desorption solvent, the removal efficiency remained as high as 98.89 %. The theoretical maximum adsorption capacity of SCTNs/AC was 3242.04 mg/g, significantly surpassing that of other adsorbents. The adsorption process adhered to the Langmuir isotherm and pseudo-second-order kinetic models, indicating that monolayer chemisorption was the predominant adsorption mechanism. Mechanistic analysis highlighted that the high adsorption efficiency of SCTNs/AC towards Rh B was attributed to the synergistic effects of pore diffusion, electrostatic interactions, π-π stacking, and hydrogen bonding. Specifically, micropores with diameters between 1 and 2 nm played a pivotal role in pore diffusion, while the incorporation of pyridine nitrogen substantially enhanced electrostatic interactions. This study not only offers an innovative approach for the high-value utilization of bituminous coal, but also provides both theoretical insights and technical support for the efficient removal of organic dyes from industrial wastewater, highlighting its environmental and economic significance.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"44 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-situ microextractive adsorption of α-pinene from fermentation broths by a recombinant yeast","authors":"Xu Zhou, Yapeng Zhang, Huipeng Gao, Quan Zhang, Lei Qin, Yuesheng Dong, Chun Li, Yaqin Sun, Zhilong Xiu","doi":"10.1016/j.seppur.2025.134043","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.134043","url":null,"abstract":"α-Pinene, a promising advanced biofuel, has garnered significant attention in the field of synthetic biology. However, its high cytotoxicity and volatility pose substantial challenges for efficient recovery from fermentation broths. This study explores a novel solid–liquid phase microextractive adsorption (SLPMA) technique to achieve in-situ separation of α-pinene from fermentation broths using a recombinant yeast. The extractant was immobilized into a polystyrene (PS) skeleton through copolymerization to prepare six resins for in-situ microextractive adsorption of α-pinene in the fermentation broth. The optimal extractant, isopropyl myristate (IPM), incorporated into the PS resin (PS-IPM) exhibited acceptable biocompatibility. Comprehensive characterization of the PS-IPM resin using FTIR, SEM, nitrogen physisorption, and TGA confirmed the successful immobilization of IPM (41.39 wt%) and material suitability. Compared to traditional extractive fermentation methods, the SLPMA process significantly enhanced cell growth promotion efficiency by 4.5 times. This improvement is attributed to the immobilization of the extractant within the porous material, which increased the extraction interface area and induced a microextraction effect. This effect enriched the α-pinene concentration in the regular fermentation broth toward the IPM phase of the PS-IPM microextractor by 57.9-fold. It increased the α-pinene concentration by 2.3-fold compared to the IPM from the extractive fermentation system. Consequently, the PS-IPM resin exhibited outstanding performance and effectively mitigated product inhibition. The resin successfully facilitated multiple cycles of in-situ α-pinene separation during fermentation, achieving a recovery of up to 95.82%. Furthermore, the removal efficiencies for inorganic salts, pigments, and proteins in the fermentation broth exceeded 98%. A delayed resin addition strategy was also implemented, further enhancing operational efficiency. FTIR analysis, combined with quantum chemical calculations, revealed that the strong van der Waals interaction is the primary driving force behind the separation process. This interaction enables the PS-IPM resin to function as an effective microextractor during adsorption. The study highlights the considerable potential of the SLPMA process for in-situ α-pinene separation during fermentation, providing a valuable reference for addressing challenges in other product-inhibited fermentation systems.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"14 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}