Separation and Purification Technology最新文献

{"title":"In situ construction of ZnFe-layered double oxides on biochar for improving interfacial adsorption-catalysis of ozone achieves efficient water purification","authors":"Qiang Tan ,&nbsp;Zhonglin Chen ,&nbsp;Jimin Shen ,&nbsp;Pengwei Yan ,&nbsp;Jing Kang ,&nbsp;Binyuan Wang ,&nbsp;Shengxin Zhao ,&nbsp;Yang Shen ,&nbsp;Yabin Li","doi":"10.1016/j.seppur.2025.135358","DOIUrl":"10.1016/j.seppur.2025.135358","url":null,"abstract":"<div><div>ZnFe-layered double oxides@biochar (ZnFe-LDO@BC) was constructed by in situ derivation of the ZnFe-LDH on biochar (BC) through a simple co-pyrolysis method for heterogeneous catalytic ozonation (HCO) progress. The dual-engine driven interface adsorption-catalysis of ozone (O₃) on ZnFe-LDO@BC achieved durable organic water decontamination. The O₃/ZnFe-LDO@BC system enhanced the utilization of O₃ and the yield of hydroxyl radicals (·OH), thus greatly benefiting organic pollutants removal. Moreover, the enrichment of O₃ and pollutants at the ZnFe-LDO@BC interface overcame the interpretation of the coexistence component, and showed unique advantages compared to traditional catalytic systems. In situ ATR-FTIR experiment and computational studies unveiled that the in situ formed Fe sites on LDO readily adsorbed H₂O to form surface -OH and thus reacted with adsorbed O₃, and mediated the ·OH dominant HCO process. The O₃/ZnFe-LDO@BC system induced non-toxic degradation of pollutants. The constructed interfacial adsorption-catalysis system proposed a new ideal for the development of HCO technology, and provided a solution approach for technical bottlenecks.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"380 ","pages":"Article 135358"},"PeriodicalIF":9.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous electrodialytic recovery of HCl and LiOH from LiCl: Modeling, optimization and experimental validation","authors":"Maria del Mar Cerrillo-Gonzalez, Raffaele Casaburo, Giuseppina Luciani, Juan Manuel Paz-Garcia, Jose Miguel Rodriguez-Maroto, Maria Villen-Guzman","doi":"10.1016/j.seppur.2025.135426","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.135426","url":null,"abstract":"The growing demand for lithium-ion batteries (LIBs) highlights the need for sustainable recycling technologies. Electro-electrodialysis (EED) has emerged as a promising alternative for regenerating chemical reagents and recovering lithium-based salts from hydrometallurgical leachates. This study investigates the electrodialytic production of HCl and LiOH from LiCl solutions using a four compartment EED cell. A mathematical model was developed to describe ions transports, acid and base regeneration and energy consumption, incorporating electrochemical and mass transport parameters. The model was validated through five batch-mode EED experiments under different operating conditions. Experimental results validated the model's accuracy in predicting the concentrations of Li⁺, Cl⁻, H⁺ and OH⁻ over time, as well as the voltage and specific energy consumption, with R² values above 0.99. The optimal performance was achieved under conditions of high initial LiOH concentration (0.5 M) and low electrode distance (8 cm), which minimized the energy consumption while maintaining high product yields. Conversely, higher initial acid concentrations reduced ion recovery, likely due to increased ionic competition and membrane transport resistance. Under the optimal conditions, specific energy consumption reached value8.3 kWh·kg⁻¹ HCl and 13.7 kWh·kg⁻¹ LiOH. The validated model provides a reliable tool for optimizing EED performance and reducing experimental effort. This work demonstrates the feasibility of using EED to selectively generate acid and base from LiCl-rich solutions and supports the development of more efficient approaches for LIB recycling.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"103 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covalent organic frameworks-based microspheres with precisely designed recognition sites for selective adsorption of luteolin","authors":"Na Su ,&nbsp;Hongxiang Ou ,&nbsp;Shucheng Liu ,&nbsp;Fang Zhu ,&nbsp;Honglai Xue ,&nbsp;Xuan Zhang","doi":"10.1016/j.seppur.2025.135370","DOIUrl":"10.1016/j.seppur.2025.135370","url":null,"abstract":"<div><div>Global agricultural activities generate substantial flavonoid-rich waste streams, which presents both resource recovery opportunities and environmental challenges. The selective separation of high-value luteolin (LTL) from such complex matrices remains difficult due to structural similarities among flavonoids. Covalent organic frameworks (COFs) are promising separation materials due to their tunable structures and functionalities. However, COFs face limitations in accurately recognizing LTL within complex environmental matrices. Key issues include insufficient specific binding sites and low functionalization density. To overcome these challenges, we developed molecularly imprinted COFs microspheres (COFs-DVA-SH MIPMCs) through a novel emulsion-based synthesis and post-modification strategy. This approach involved constructing hollow vinyl-functionalized COFs microspheres via emulsion polymerization, followed by dithiol linker grafting through thiol-ene click reaction, and culminating in boronic acid affinity site imprinting. This yielded COFs microspheres with precise recognition capabilities. The COFs-DVA-SH MIPMCs combine boronate affinity with molecular imprinting advantages to enable selective LTL extraction. They demonstrate significant recognition capacity (67.97 mg g⁻¹), rapid mass transfer (180 min), and high selectivity (<em>IF</em> = 2.89) under alkaline conditions. The adsorbent also exhibits excellent stability, maintaining 93.7 % capacity after 5 cycles and robust thermal stability. This work provides a new strategy for specific separation of natural flavonoids using COFs, supporting sustainable valorization of agricultural waste through advanced separation technologies.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"380 ","pages":"Article 135370"},"PeriodicalIF":9.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NaClO changes metabolic pathway by regulating oxidative stress and virulence of microplastics to activated sludge in MBR","authors":"Jin Xu, Xiuhong Liu, Jiaxin Li, Shiyong Zhang, Qing Yang","doi":"10.1016/j.seppur.2025.135310","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.135310","url":null,"abstract":"Microplastics (MPs) and NaClO were both prevalent in MBRs, and their coexistence poses a potential threat to nitrogen biotransformation in wastewater treatment systems. However, investigations on how MPs combined with NaClO affect the microbial nitrogen conversion and metabolism of the activated sludge are still scanty. In this study, the MPs or NaClO exposure alone had marginal impacts on the nitrogen removal in MBRs, while the two pollutants' coexistence in MBR, the total nitrogen removal efficiency decreased from 83.59 % to 74.46 % by the suppression of nitrogen transformation processes. Metagenomic analysis revealed that the abundance of functional genes encoded by key enzymes related to nitrogen transformation, including nirK, norB, nosZ and nirS, were also decreased with MPs and NaClO co-exposure. The reason for the above phenomenon may be the biotoxicity of MPs to activated sludge caused by NaClO, the ROS production increased to 128.57 % with MPs and NaClO co-exposure. The increase of intracellular oxidative stress level and virulence factors synthesis confirmed that NaClO can aggravate the toxicity of MPs to activated sludge. The increased toxicity of MPs to activated sludge caused by NaClO may be attributed to the oxidation of MPs, that is, the change of functional groups. This study provides vital insights into the responses of microbial community structure and nitrogen conversion processes to interference MPs combined with NaClO backwash agent residual in MBRs.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"19 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergy of sulfate radical-driven oxidation with dynamic in situ Fe(III) coagulation for enhanced NOM precursor removal","authors":"Lap-Cuong Hua, Yosheng Lin, Thi Ngoc Anh Nguyen, Jr Lin Lin, Chihpin Huang","doi":"10.1016/j.seppur.2025.135378","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.135378","url":null,"abstract":"Removal of natural organic matter (NOM) by conventional coagulation is often limited. This study investigated Fe(II)-activated sulfate-based oxidations (Fe(II)@SBOs), including peroxymonosulfate and peroxydisulfate (Fe(II)@PMS and Fe(II)@PS), for enhanced removal of NOM-derived disinfection by-products (DBPs). We provided fresh evidence exploring the synergistic roles of in situ radical oxidation and swift coagulation in Fe(II)@SBOs. At pH 7 and a low molar dose of DOC:Oxidant: Fe of 1:0.5:0.5, Fe(II)@PMS and Fe(II)@PS achieved better removals in DOC (55–59 %), fluorophoric substances (64–71 %), and DBP precursors (59–71 %), outperforming traditional Fe(III) by approximately 20–30 % for all tested parameters. At a high dose of 1:2:2, both Fe(II)@SBO systems reduced 80–90 % DBP precursors, which mitigated the calculated cytotoxicity potency of treated water by 0.5 to 1 order of magnitude lower than untreated water. Radical identification confirmed that Fe(II)@PMS generated &lt;sup&gt;•&lt;/sup&gt;OH and SO&lt;sub&gt;4&lt;/sub&gt;&lt;sup&gt;•–&lt;/sup&gt; radicals more effectively than Fe(II)@PS. These radicals oxidized NOM, transforming its carbon‑carbon structure from a low (i.e. C&lt;img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/&gt;C/C&lt;img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/&gt;H, C&lt;img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/&gt;O) to a high degree of oxygenated carbonaceous groups (i.e. C&lt;img alt=\"double bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/dbnd.gif\" style=\"vertical-align:middle\"/&gt;O, O&lt;img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/&gt;C&lt;img alt=\"double bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/dbnd.gif\" style=\"vertical-align:middle\"/&gt;O). They reduced DBP formation via structural alternation of the precursor rather than complete organic mitigation, as evidenced by their minor impact in scavenging experiments. Instead, the newly formed Fe(III) characterized by monomeric and polymeric iron, governed the NOM removal process as demonstrated by chelating experiments. In situ Fe(III) facilitated swift coagulation for better charge neutralization with oxidized NOM and ultimately produced more compact flocs with a O&lt;img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/&gt;O structure. These characteristics were opposed to conventional Fe(III), which formed loose and elongated flocs. This study elaborates the synergistic roles of in situ oxidation and coagulation in Fe(II)","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"94 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acid-base dual-functional cooperation and molecular sieving in hypercrosslinked porous polymers for CO2 capture","authors":"Pengcheng Ma, Wanshuang Zhou, Cong Yu, Zhuang Liu, Qiang Chen, Shi-Peng Sun, Xinbo Wang","doi":"10.1016/j.seppur.2025.135242","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.135242","url":null,"abstract":"Efficient CO₂ capture and separation are essential to enhance natural gas utilization and reduce coal-fired flue gas emissions, mitigating the climate change. Here, we introduce a novel acid-base dual-functional synergistic adsorption strategy by synthesizing a hypercrosslinked porous polymer (HCP-A-S) containing both amino and sulfonic acid functionalities. The material exhibits 0.34-nm ultramicropores and cooperative –NH₂/–SO₃H groups that preferentially adsorb CO₂, with CO₂ uptake and CO₂/N₂ selectivity doubling that of the corresponding single-site HCP. DFT calculations reveal that the negatively charged amino groups and sulfonic acid moieties synergistically enhance CO₂ affinity through strong electrostatic and dipole–quadrupole interactions, facilitating highly selective capture. Dynamic breakthrough experiments confirm HCP-A-S's superior CO₂/N₂ separation performance, high working capacity, and excellent recyclability. This dual-polar-site approach overcomes limitations of traditional single-site adsorbents and offers a cost-effective, scalable pathway to high-performance carbon capture materials.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"6 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surfactant-stabilized cyclopentane hydrate emulsions for removing tetramethylammonium hydroxide from semiconductor wastewater","authors":"Jae-Cheol Lee ,&nbsp;Wonhyeong Lee ,&nbsp;Juhwan Kang ,&nbsp;Min-Kyung Kim ,&nbsp;Ahhyun Roh ,&nbsp;Jae Hyun Jeong ,&nbsp;Jae W. Lee ,&nbsp;Yun-Ho Ahn","doi":"10.1016/j.seppur.2025.135435","DOIUrl":"10.1016/j.seppur.2025.135435","url":null,"abstract":"<div><div>This study presents an innovative hydrate-based wastewater treatment approach specifically designed for semiconductor wastewater containing tetramethylammonium hydroxide (TMAH), utilizing cyclopentane (CP)-in-water emulsions stabilized by nonionic surfactants Span 80 and Vitamin E-TS. The stabilized emulsions significantly accelerated hydrate formation kinetics, reducing the induction time from 313.33 min to approximately 12.67 min (a 96 % decrease), thus greatly enhancing the process's energy efficiency. Structural analyses using powder X-ray diffraction (PXRD) and Raman spectroscopy confirmed that TMAH molecules at concentrations of 515 mg/L were effectively excluded from the hydrate structure, demonstrating no interference with hydrate crystalline structures or cage occupancy. Furthermore, incorporating Vitamin E-TS as an anti-agglomerant promoted the formation of porous hydrate structures, increasing TMAH removal efficiency substantially from 45.51 % to 62.96 %, though reducing water recovery from 69.74 % to 61.64 %. Subsequent post-washing procedures further increased TMAH removal efficiency to 74.88 % but decreased water recovery to 49.24 % due to partial hydrate melting. These findings underscore the importance of balancing water recovery and contaminant removal efficiency, providing essential insights for optimizing hydrate-based wastewater treatment processes, and highlighting its potential as an energy-efficient and sustainable solution for semiconductor wastewater and other industrial wastewater containing persistent organic contaminants.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"380 ","pages":"Article 135435"},"PeriodicalIF":9.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reclaiming value from phosphate mine waste rock: An integrated flowsheet for sustainable recovery","authors":"Hicham Amar, Yassine Taha, Abdellatif Elghali, Yassine Ait-Khouia, Manar Derhy, Rachid Hakkou, Mostafa Benzaazoua","doi":"10.1016/j.seppur.2025.135421","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.135421","url":null,"abstract":"Phosphate mining operations generate substantial quantities of waste rock as a byproduct of ore extraction, referred to as phosphate mine waste rock (PMWR) and stored in large stockpiles. PMWR retains significant residual phosphate yet is challenging to process due to lithological heterogeneity and a wide particle size distribution, necessitating the development of an optimized processing strategy. This study investigates a beneficiation route integrating size classification, sensor-based sorting (SBS) coupled with comminution, and reverse flotation for PMWR upgrading. Classification and sorting partitioned the material into a fine fraction (FF, &lt;10 mm), dominated by sandy phosphate, and a coarse fraction (CF, &gt;10 mm), composed of indured phosphate (IndP). Chemical and mineralogical analyses revealed enrichment in carbonate-fluorapatite (CFA) within the FF (63.5 %) compared to the IndP fraction (50.8 %), with more than 80 % of CFA grains free in both fractions. Reverse flotation with phosphoric acid ester and alkyl ether amine collectors, as well as phosphoric acid as depressant and pH modifier, exhibited effective gangue elimination and satisfactory selectivity, yielding an 11 % increase in CFA grade with 88.7 % recovery for the FF, and an 18 % increase with 89.4 % recovery for the IndP. Based on these outcomes, a novel process flowsheet is proposed to support resource efficiency and reduce the environmental footprint of PMWR. Valorization of residual phosphate through this approach constitutes a critical step toward advancing circular economy principles in sustainable phosphate mining.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"62 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into the influence mechanisms of particle size on the aging behavior and TCE removal of biogenic sulfidated mZVI in groundwater","authors":"Haoran Tian, Jia Xin, Jiahui Lu, Weiran Meng, Yihan Wang, Qianyi Zhou","doi":"10.1016/j.seppur.2025.135436","DOIUrl":"https://doi.org/10.1016/j.seppur.2025.135436","url":null,"abstract":"In-situ biogenic sulfidation of microscale zero-valent iron (mZVI) is an efficient and green method to enhance its dechlorination in groundwater. However, for practical field applications, the technology must maintain long-term effectiveness. At present, the performance evolution of aged biogenic sulfidated mZVI (BS-mZVI), especially regarding the influence of particle size, remains unclear and needs further investigation. In this study, BS-mZVI with two particle sizes (7 μm and 30 μm) was aged for 15, 30, and 45 days and systematically compared. The results showed that smaller particles (7 μm) achieved rapid initial trichloroethylene (TCE) removal (95 % in 6 days), but their reactivity declined with prolonged aging (<em>k</em>_SA = 1.12 × 10⁻² L·m⁻²·d⁻¹ with 45-day aging). Conversely, larger particles (30 μm) exhibited improved reactivity over time, reaching a <em>k</em>_SA of 1.57 × 10⁻² L·m⁻²·d⁻¹ after 45-day aging while maintaining over 92 % TCE removal. Surface characterization revealed that aged BS-mZVI (7 μm) developed increased hydro(oxide) passivation layers (Fe₂O₃/FeOOH) from 15 to 45 days of aging, which decreased its reactivity. In contrast, aged BS-mZVI (30 μm) gradually formed conductive FeS_x shells during aging, retaining hydrophobicity and enhancing reactivity. Metagenomic analysis further revealed that with prolonged aging (15 to 45 days), the 30 μm BS-mZVI enriched sulfate-reducing bacteria (SRB) and iron-reducing bacteria (IRB), accompanied by higher abundances of key functional genes involved in sulfate and iron reduction, thereby promoting sustained TCE degradation. These particle size-dependent results demonstrate that smaller BS-mZVI enables rapid TCE decontamination, whereas larger particles offer prolonged reactivity, helping to choose materials based on the needed remediation timeframe required in applications.","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"68 1","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective separation of quercetin and p-Coumaric acid based on new Hansen solubility parameters","authors":"Iván Montenegro,&nbsp;Celeste Fernández,&nbsp;Ángeles Domínguez,&nbsp;Begoña González,&nbsp;Elena Gómez","doi":"10.1016/j.seppur.2025.135428","DOIUrl":"10.1016/j.seppur.2025.135428","url":null,"abstract":"<div><div>Polyphenols such as quercetin and <em>p</em>-coumaric acid are valuable bioactive compounds, but their selective separation remains a challenge due to their structural similarity and coexistence in natural matrices. In this work, the selective separation of quercetin and <em>p</em>-coumaric acid is addressed based on experimental solubility studies and calculated new Hansen solubility parameters (HSPs). Solubility of both polyphenols was first determined in 21 mono-solvents at 298.15 K and 0.1 MPa and subsequently employed for HSP calculation. Theoretical HSP-based predictions were validated with solubility measurements in binary solvent mixtures combining methanol, ethanol, methyl ethyl ketone (MEK), and methyl isobutyl ketone (MiBK). Based on preliminary solubility results and calculated HSPs, selectivity of methanol and MiBK with quercetin and <em>p</em>-coumaric acid was evaluated. Three-dimensional Hansen spheres showed strong agreement with preliminary solubility data in mono-solvents. HSP-based predictions revealed solubility maxima in those mixtures composed of solvents with different functional groups, in accordance with experimental results. As for selectivity tests, MiBK showed high extraction efficiencies for both compounds, whereas methanol exhibited great potential in selectively separating <em>p</em>-coumaric acid. Eventually, a two-step separation procedure is proposed, using methanol first to selectively extract <em>p</em>-coumaric acid, and subsequently employing MiBK to purify residual quercetin. Overall, this work underscores the importance of experimental HSP-based approaches and Hansen theory in solubility prediction and solvent selection strategies for the separation of bioactive compounds from natural sources.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":"380 ","pages":"Article 135428"},"PeriodicalIF":9.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}