Design and optimization of extractive distillation for separating methyl ethyl ketone/isopropanol/n-heptane ternary azeotropes

IF 9 1区工程技术 Q1 ENGINEERING, CHEMICAL

Separation and Purification Technology Pub Date : 2025-10-08 DOI:10.1016/j.seppur.2025.135559

Shuangxin Fan, Yan Cheng, Xinyuan Cheng, Tong Xia, Jing Li, Jun Li, Lanyi Sun

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Abstract

In pharmaceutical manufacturing, there is a widespread presence of industrial waste liquids containing methyl ethyl ketone, isopropanol, and n-heptane. This work employs extractive distillation to separate this multi-azeotropic system. Firstly, the conventional extractive distillation process (CED) is designed, and the optimal parameters of the three-objective trade-off are obtained by multi-objective optimization. Then, the side-stream distillation, intermediate reboiler and heat integration enhancement methods are introduced to reduce energy consumption and costs. The results demonstrate that the double side-stream extractive distillation with intermediate reboiler and heat integration process (DSSEDIR-HI) shows the best economic and environmental performance. Compared to the CED process, the total annual cost is reduced by 23.9 %, CO₂ emissions are decreased by 42.5 %, and thermodynamic efficiency is improved by 68.4 %. This study provides a sustainable pathway for the separation of methyl ethyl ketone/isopropanol/n-heptane mixture.

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萃取精馏分离甲乙基酮/异丙醇/正庚烷三元共沸物的设计与优化

在制药业中，广泛存在含有甲基乙基酮、异丙醇和正庚烷的工业废液。本工作采用萃取精馏分离多共沸体系。首先对传统萃取精馏工艺进行设计，通过多目标优化得到三目标权衡的最优参数；然后介绍了侧流精馏、中间再沸器和热集成强化方法，以降低能耗和成本。结果表明，中间再沸-热集成双侧流萃取精馏工艺（DSSEDIR-HI）具有最佳的经济效益和环境效益。与CED工艺相比，年总成本降低23.9 %，二氧化碳排放量降低42.5 %，热效率提高68.4% %。本研究为甲基乙基酮/异丙醇/正庚烷混合物的分离提供了一条可持续的途径。

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来源期刊

Separation and Purification Technology 工程技术-工程：化工

CiteScore

14.00

自引率

12.80%

发文量

2347

审稿时长

43 days

期刊介绍： Separation and Purification Technology is a premier journal committed to sharing innovative methods for separation and purification in chemical and environmental engineering, encompassing both homogeneous solutions and heterogeneous mixtures. Our scope includes the separation and/or purification of liquids, vapors, and gases, as well as carbon capture and separation techniques. However, it's important to note that methods solely intended for analytical purposes are not within the scope of the journal. Additionally, disciplines such as soil science, polymer science, and metallurgy fall outside the purview of Separation and Purification Technology. Join us in advancing the field of separation and purification methods for sustainable solutions in chemical and environmental engineering.