Electrochemistry Communications最新文献

{"title":"Diffusion-affected charge transfer: demonstration experiment for the linear relationship between current and its semiintegral","authors":"Tamás Pajkossy","doi":"10.1016/j.elecom.2025.107969","DOIUrl":"10.1016/j.elecom.2025.107969","url":null,"abstract":"<div><div>Diffusion-affected charge transfer is a basic situation of electrochemical kinetics; the rate coefficients are often estimated by analyzing cyclic voltammograms. Provided that a couple of conditions hold, decoupling of diffusion and charge transfer is possible by using a recent theory leading to a linear relation of the current and its so-called semiintegral. Accordingly, a set of voltammograms of such reactions, measured with varied scan rates, can be transformed into two functions characteristic of charge transfer and diffusion separately, yielding charge transfer rate coefficients. We present here voltammograms measured on a well-known electrochemical system (gold electrode in a ferrocyanide/ferricyanide containing aqueous solution) and demonstrate the applicability of the above-mentioned linear relation; finally, we calculate the charge transfer rate coefficients as a function of the electrode potential. The main advantages and disadvantages of the analysis method are discussed, along with the limitations of the practical applicability.</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"178 ","pages":"Article 107969"},"PeriodicalIF":4.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in biomarkers for cardiovascular diseases and biosensing precisely via modification method of electrochemical biosensor: A Review","authors":"Xinjie Song ,&nbsp;Jing Zhang ,&nbsp;Shuang Li","doi":"10.1016/j.elecom.2025.107968","DOIUrl":"10.1016/j.elecom.2025.107968","url":null,"abstract":"<div><div>Cardiovascular diseases (CVDs) continue to represent the leading cause of global mortality and disability, highlighting the urgent need for early detection, intervention, and prevention strategies to improve patient outcomes. While significant advancements have been achieved in diagnostic approaches - including clinical risk stratification and biomarker panels - the increasing prevalence of CVDs presents substantial challenges, particularly in the context of accelerating global aging populations. This situation demands the identification and clinical validation of highly sensitive circulating biomarkers that can detect early pathological changes, coupled with the development of precise analytical platforms. Electrochemical biosensors have emerged as critical diagnostic tools for CVDs, offering exceptional advantages such as sub-picomolar sensitivity, multiplexed detection capability, rapid response kinetics, and miniaturization potential. Herein, the biomarkers for cardiovascular disease and the biosensing for them were comprehensively reviewed. Firstly, the highly specific and novel biomarkers closely related to three cardiovascular diseases which can reflect the presence or severity of the disease to a certain extent. Secondly, several common types of electrochemical biosensors and their modification method were emphasized. Finally, we summarized the advantages and disadvantages of each electrochemical biosensor modification method, as well as the development trends in the future, and provided some insights for better application in clinical practice to benefit human health.</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"178 ","pages":"Article 107968"},"PeriodicalIF":4.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wireless electrochemical fabrication of tungsten oxide nanoporous layers in closed bipolar cells","authors":"Marcela Sepúlveda ,&nbsp;Kaushik Baishya ,&nbsp;Jhonatan Rodriguez-Pereira ,&nbsp;Veronika Cicmancova ,&nbsp;Ludek Hromadko ,&nbsp;Jan M. Macak","doi":"10.1016/j.elecom.2025.107963","DOIUrl":"10.1016/j.elecom.2025.107963","url":null,"abstract":"<div><div>In this work, the anodization of tungsten (W) foils using closed bipolar electrochemical cells is demonstrated for the first time. The anodization was done using three different electrolytes: (1) 1 M NH₄NO₃, 1 wt%. H₂O in ethylene glycol (EG); (2) 1 M (NH₄)₂SO₄, 75 mM NH₄F in H₂O; and (3) 170 mM NH₄ 1.5 wt%. H₂O in EG. Different square-wave potentials and frequencies were applied during the anodization. Among the tested electrolytes, electrolyte 1 produced the most well-defined and homogeneous WO₃ nanoporous (NP) layers. X-ray photoelectron spectroscopy confirmed the presence of multiple W oxidation states on the WO₃ NP layers using electrolytes 1 and 2, with W⁶⁺ and W⁵⁺ being the dominant species. The results demonstrate well-defined WO₃ NP layers with a high W⁶⁺ species concentration and less than 10 at.% W⁵⁺ is achieved using electrolyte 1. These findings provide valuable insights into the relationship between the electrolyte composition, W oxidation states, and the morphology of WO₃ NP layers.</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"176 ","pages":"Article 107963"},"PeriodicalIF":4.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boosting energy density of MXenes: Atomically-resolved ion polar rotation within electrolyte-specific-width interlayers","authors":"Rui Wang ,&nbsp;Zheng Bo ,&nbsp;Zifeng Lin ,&nbsp;Yujie Chen ,&nbsp;Yajing Song ,&nbsp;Zhu Liu ,&nbsp;Guang Yang ,&nbsp;Suya Liu ,&nbsp;Jun Liu ,&nbsp;Guojie Zhang ,&nbsp;Jianhua Yan ,&nbsp;Kefa Cen ,&nbsp;Qian Yu ,&nbsp;Kostya Ken Ostrikov","doi":"10.1016/j.elecom.2025.107959","DOIUrl":"10.1016/j.elecom.2025.107959","url":null,"abstract":"<div><div>Layer-structured pseudocapacitive electrode materials show excellent potential for overcoming the kinetic constraints of batteries while achieving charge storage capacities greater than those of electrical double-layer capacitors. However, real-world applications are limited by the lack of effective mechanisms to strip electrolyte ions from solvent atoms and control their interactions and charge exchange with the layered electrode materials. Here, we discover the ion polar rotation within sub-nanometer interlayer space of two-dimensional MXene sheets by directly imaging interlayer ionic structure and measuring the local charge transfer. Unlike common ion desolvation, ion polar rotation rearranges solvent molecules and creates more exposure of intercalated ions, eliminating the need for long-range ion diffusion and desolvation. This effect enhances ion-electrode charge transfer at a unique interlayer spacing for each solvent. We demonstrated the efficacy of the polar rotation mechanism by designing a hierarchically structured MXene electrode with the optimal interlayer spacing, which shows Li⁺ storage capacitance of up to 310 F<!--> <!-->g⁻¹ (744 F cm⁻³) in LiTFSI/PC system and good rate performance.</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"176 ","pages":"Article 107959"},"PeriodicalIF":4.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies of structural, optical, magnetic and dielectric properties of Sr0.7Bi0.2(Ti1-xZrx)O3 0.0 ≤ x ≤ 0.6 ceramics for wireless application","authors":"Inamullah ,&nbsp;Asad Ali ,&nbsp;Kashif Safeen ,&nbsp;Salhah Hamed Alrefaee ,&nbsp;Aiyeshah Alhodaib ,&nbsp;Akif Safeen ,&nbsp;Shaxnoza Saydaxmetova ,&nbsp;Salah Knani ,&nbsp;Ali Algahtani ,&nbsp;Vineet Tirth ,&nbsp;Abid Zaman","doi":"10.1016/j.elecom.2025.107962","DOIUrl":"10.1016/j.elecom.2025.107962","url":null,"abstract":"<div><div>The solid solution of Sr_0.7Bi_0.2(Ti_1-xZr_x)O₃ 0.0 ≤ x ≤ 0.6 ceramics has been prepared by mixed oxide route. In this work, the impact produced by doping Zr⁴⁺ on the structural, optical, morphological, magnetic and dielectric properties of Sr_0.7Bi_0.2(Ti_1-x Zr_x)O₃ ceramics has been investigated with respect to the frequency range of 1KHz to 1 MHz. According to the X-ray diffraction patterns, the base sample is a member of the space group pm-3 m and has a cubic structure. Using a scanning electron microscope (SEM), the samples' surface appearance and average grain size (0.493–0.381 μm) were examined. The difference of ionic radius between Ti⁴⁺ and Zr⁴⁺ ions have been observed to cause a decrease in grain size with Zr⁴⁺ doping. The FTIR study confirms the presence of metal‑oxygen bond and functional groups. The observed peak emission at 710 nm corresponds to the excitation energy of 1.76 eV in photoluminescence spectra. The UV visible absorption spectra results, the band gape energy (E_g) drops from 4.83 eV to 4.43 eV with an increasing the Zr⁴⁺ contents. The magnetic properties of Sr_0.7Bi_0.2(Ti_1-xZr_x)O₃ 0.00 ≤ x ≤ 0.60 ceramics at room temperature is increases with Zr⁴⁺ content, due to lattice distortions, improved exchange interactions, and oxygen vacancies that facilitate magnetic ordering, In addition to increasing domain wall pinning, Zr⁴⁺ doping decreases the grain size, which qualifies these ceramics for use in electromagnetic devices and magnetic storage. The dielectric properties of the prepared samples were strongly dependent on the frequencies, temperature, and as well as on concentration. The dielectric constant's temperature and content variations are most likely caused by the charge carrier hopping process and thermally induced dipolar relaxation. The overall best results are appropriate for applications using wireless devices.</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"176 ","pages":"Article 107962"},"PeriodicalIF":4.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical aptamer sensor for detection of SARS-CoV-2 S1 protein in real pharyngeal swab samples","authors":"Yi Wang ,&nbsp;Rui Bao ,&nbsp;Xin Zhang ,&nbsp;Chao Wang ,&nbsp;Chunxia Song ,&nbsp;Min Song ,&nbsp;Hongjuan Jiang ,&nbsp;Tan Wang ,&nbsp;Xiangwei Wu ,&nbsp;Zhaofeng Luo ,&nbsp;Ying Lu","doi":"10.1016/j.elecom.2025.107961","DOIUrl":"10.1016/j.elecom.2025.107961","url":null,"abstract":"<div><div>The global impact of the COVID-19 (Corona virus disease 2019) pandemic has been significant and the reliability of widely used diagnostic methods was often hindered by high false-negative rates as well as instrumentation limitations. In this context, electrochemical aptamer sensors can offer various advantages, including high sensitivity, low cost and the ability to perform detection directly on body fluids without the need for expensive equipments. In this study, a sensor was developed by hybridizing a SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)-specific spike glycoprotein (S protein) aptamer with sulfhydryl- and ferrocene-labeled single-stranded DNA complementary to the aptamer. This design exhibited enhanced sensitivity compared with the labeled aptamer alone. Furthermore, the sensor's sensitivity, specificity and reproducibility were validated, and the results showed a linear relationship with the logarithm of the S1 protein concentration, which ranged from 10 fM to 100 nM (Δ<em>I</em>_p = 0.11 log C_{S1 protein} / fM - 0.021, R² = 0.99), with a LOD (limit of detection) of 1 fM (S/N = 3). Furthermore, the sensor successfully detected the S1 protein in pharyngeal swab samples from SAR S-CoV-2 patients. This study provides a promising approach for addressing public health crises and proposes a novel solution for managing infectious diseases during pandemics</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"176 ","pages":"Article 107961"},"PeriodicalIF":4.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MoS2/NiO hybridized with reduced graphene oxide for glycerol and sorbitol electrooxidation","authors":"Mohammad Bagher Askari ,&nbsp;Sadegh Azizi ,&nbsp;Mohammad Taghi Tourchi Moghadam ,&nbsp;Parisa Salarizadeh","doi":"10.1016/j.elecom.2025.107952","DOIUrl":"10.1016/j.elecom.2025.107952","url":null,"abstract":"<div><div>Using glycerol and sorbitol as fuels in fuel cells has received limited attention in the literature. This study presents the synthesis of a composite material comprising molybdenum disulfide (MoS₂) and nickel oxide (NiO) via a hydrothermal method, which was subsequently hybridized with reduced graphene oxide (RGO) to enhance its catalytic performance. The catalytic activity of the MoS₂/NiO/RGO composite for the oxidation of glycerol and sorbitol was systematically evaluated. The results demonstrated exceptional catalytic activity, with the current density of 311 mA/cm² at 0.5 V for MoS₂/NiO/RGO catalyst during glycerol oxidation reaction (GOR). Furthermore, the catalyst exhibited remarkable stability, maintaining 86.6 % of its activity after 5 h of chronoamperometric analysis in the glycerol oxidation reaction. In the case of the sorbitol oxidation reaction (SOR), the MoS₂/NiO/RGO composite delivered impressive results, achieving 205 mA/cm² at 0.51 V and a stability of 90.2 %. This research is promising for introducing cost-effective, durable, and efficient catalysts to oxidize alternative fuels, with potential applications in fuel cell anodes.</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"176 ","pages":"Article 107952"},"PeriodicalIF":4.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-principles investigation of structural, electronic, mechanical, and optical properties of Tl-based halide perovskites (TlXF3; X = Ti, Zr) for reflective coating applications","authors":"Amina ,&nbsp;Maryam Liaqat ,&nbsp;Salhah Hamed Alrefaee ,&nbsp;Muhammad Inam Ul Haq ,&nbsp;Dilsora Abduvalieva ,&nbsp;Naseem Akhter ,&nbsp;Vineet Tirth ,&nbsp;Ali Algahtani ,&nbsp;Amnah Mohammed Alsuhaibani ,&nbsp;Moamen S. Refat ,&nbsp;N.M.A. Hadia","doi":"10.1016/j.elecom.2025.107951","DOIUrl":"10.1016/j.elecom.2025.107951","url":null,"abstract":"<div><div>The pursuit of advanced materials to address global energy challenges has directed attention to halide perovskites, known for their promising technological applications. In this study, we investigate the structural, electronic, elastic, and optical properties of Tl-based fluoro-perovskites TlXF₃ (X = Ti, Zr) using density functional theory (DFT) with the Wien2k package. Structural stability is confirmed via tolerance factor analysis, while thermodynamic stability is validated through negative formation energies. Phonon dispersion calculations affirm the dynamic stability of these compounds. The optimized lattice constants are found to be 4.25 and 4.47 Å. Employing the modified Becke-Johnson potential, the electronic band structure and density of states are computed revealing a half-metallic nature of both compounds, with excellent consistency between band structure and density of states findings. In both material the valence and conductions bands are overlapped at Fermi level for spin up configuration while in spin down configuration they have band gap of 4.8 eV and 5.6 eV for TlTiF₃ and TlZrF₃ respectively. Elastic properties show that both TlTiF₃ and TlZrF₃ meet mechanical stability criteria, with TlTiF₃ demonstrating superior resistance to compressive and shear stresses, indicating enhanced mechanical robustness. The elastic analysis further indicates anisotropic, ductile behavior in both compounds. Optical analysis across a broad energy range highlights the potential of these materials for optoelectronic applications, suggesting their suitability for advanced device architectures. This study provides a foundation for further experimental exploration and device innovation in the field of halide perovskites.</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"177 ","pages":"Article 107951"},"PeriodicalIF":4.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of dry-coated fumed metal oxides for enhanced cycling performance of SiOx/C anodes in lithium-ion batteries","authors":"Ana L. Azevedo Costa ,&nbsp;Mareike Liebertseder ,&nbsp;Tatiana Gambaryan-Roisman ,&nbsp;Daniel Esken ,&nbsp;Frank Menzel","doi":"10.1016/j.elecom.2025.107941","DOIUrl":"10.1016/j.elecom.2025.107941","url":null,"abstract":"<div><div>Silicon (Si) is a promising anode material for next-generation lithium-ion batteries (LIBs) due to its high theoretical capacity. However, its practical application is hindered by significant volume changes during cycling, leading to particle pulverization, loss of electrical contact, and rapid capacity fading. To address these challenges, we study the effect of dry particle coating with nanostructured fumed metal oxides (TiO<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>, MgO, ZrO<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>, and Al<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>O<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span>) on enhancing the electrochemical performance of SiO<span><math><msub><mrow></mrow><mrow><mi>x</mi></mrow></msub></math></span>/C anodes. The dry coating process, a facile and scalable technique, effectively attaches the metal oxide nanoparticles onto the SiO<span><math><msub><mrow></mrow><mrow><mi>x</mi></mrow></msub></math></span>/C surface, forming a protective layer. The coated anode active materials (AAMs) exhibit improved cycling stability and rate capability compared to the uncoated SiO<span><math><msub><mrow></mrow><mrow><mi>x</mi></mrow></msub></math></span>/C, with the Al<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>O<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span>-coated anode demonstrating the most promising overall performance. The effective and uniform distribution of the porous coating acts as a protective layer, reducing side reactions while simultaneously enhancing ion diffusion kinetics and improving electrolyte accessibility. Detailed characterization reveals that the Al<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span>O<span><math><msub><mrow></mrow><mrow><mn>3</mn></mrow></msub></math></span> coating promotes the controlled formation of a LiF-rich solid electrolyte interphase (SEI) layer, contributing to enhanced ionic conductivity and stability. This study highlights the potential of dry particle coating with different metal oxides as a promising strategy for developing high-performance Si-based anodes for next-generation LIBs.</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"177 ","pages":"Article 107941"},"PeriodicalIF":4.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of the All-in-One electrode in an electrochemical flow cell for in situ hydrogen peroxide supply in hydroxylation mediated by immobilized unspecific peroxygenase","authors":"Giovanni V. Sayoga ,&nbsp;Victoria S. Bueschler ,&nbsp;Hubert Beisch ,&nbsp;Bodo Fiedler ,&nbsp;Daniel Ohde ,&nbsp;Andreas Liese","doi":"10.1016/j.elecom.2025.107949","DOIUrl":"10.1016/j.elecom.2025.107949","url":null,"abstract":"<div><div>Hydrogen peroxide (H₂O₂) is a strong oxidizing agent that is commonly employed in chemical synthesis. Nevertheless, its utilization as a cosubstrate in biocatalytic reactions remains limited due to the deactivating effect on biocatalysts at an elevated concentration. An electrochemical synthesis of H₂O₂ represents an attractive approach, offering a controllable <em>in situ</em> generation of H₂O₂ without producing complex by-products. The objective of this study is to demonstrate the feasibility of the <em>in situ</em> electrogeneration of H₂O₂ using the All-in-One (AiO) electrode within a flow reactor technology. Integrating a bioelectrochemical system (BES) into a flow reactor technology, such as a flow cell, presents an alternative strategy for scale-up. In this study, the <em>in situ</em> generation of H₂O₂ is coupled with the hydroxylation of 4-ethylbenzoic acid catalyzed by the immobilized recombinant unspecific peroxygenase from <em>Agrocybe aegerita</em> (r<em>Aae</em>UPO) within a complete BES under batch and fed-batch operation modes. The electrochemical flow cell facilitates a controllable H₂O₂ generation by adjusting experimental parameters such as current density, aeration rate and residence time. The flow cell BES equipped with the AiO electrode yielded a catalytic productivity as high as 1.24 ± 0.02 mM h⁻¹ (4.95 ± 0.1 g L⁻1 d⁻¹), a total turnover number of r<em>Aae</em>UPO up to 3.38 · 10⁵ ± 702 mol mol⁻¹ and a turnover frequency up to 8.34 ± 0.14 s⁻¹.</div></div>","PeriodicalId":304,"journal":{"name":"Electrochemistry Communications","volume":"177 ","pages":"Article 107949"},"PeriodicalIF":4.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}