Biomechanics and Modeling in Mechanobiology最新文献

Noninvasive estimation of central blood pressure through fluid-structure interaction modeling. 通过流体-结构相互作用模型对中心血压进行无创估算。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-12-20 DOI: 10.1007/s10237-024-01916-5

Peishuo Wu, Chi Zhu

{"title":"Noninvasive estimation of central blood pressure through fluid-structure interaction modeling.","authors":"Peishuo Wu, Chi Zhu","doi":"10.1007/s10237-024-01916-5","DOIUrl":"https://doi.org/10.1007/s10237-024-01916-5","url":null,"abstract":"Central blood pressure (cBP) is considered a superior indicator of cardiovascular fitness than brachial blood pressure (bBP). Even though bBP is easy to measure noninvasively, it is usually higher than cBP due to pulse wave amplification, characterized by the gradual increase in peak systolic pressure during pulse wave propagation. In this study, we aim to develop an individualized transfer function that can accurately estimate cBP from bBP. We first construct a three-dimensional, patient-specific model of the upper limb arterial system using fluid-structure interaction simulations, incorporating variable material properties and complex boundary conditions. Then, we develop an analytical brachial-aortic transfer function based on novel solutions for compliant vessels. The accuracy of this transfer function is successfully validated against numerical simulation results, which effectively reproduce pulse wave propagation and amplification, with key hemodynamic parameters falling within the range of clinical measurements. Further analysis of the transfer function reveals that cBP is a linear combination of bBP and aortic flow rate in the frequency domain, with the coefficients determined by vessel geometry, material properties, and boundary conditions. Additionally, bBP primarily contributes to the steady component of cBP, while the aortic flow rate is responsible for the pulsatile component. Furthermore, local sensitivity analysis indicates that the lumen radius is the most influential parameter in accurately estimating cBP. Although not directly applicable clinically, the proposed transfer function enhances understanding of the underlying physics-highlighting the importance of aortic flow and lumen radius-and can guide the development of more practical transfer functions.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full-field, frequency-domain comparison of simulated and measured human brain deformation. 模拟和测量人脑变形的全场频域对比。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-12-20 DOI: 10.1007/s10237-024-01913-8

Amir H G Arani, Ruth J Okamoto, Jordan D Escarcega, Antoine Jerusalem, Ahmed A Alshareef, Philip V Bayly

{"title":"Full-field, frequency-domain comparison of simulated and measured human brain deformation.","authors":"Amir H G Arani, Ruth J Okamoto, Jordan D Escarcega, Antoine Jerusalem, Ahmed A Alshareef, Philip V Bayly","doi":"10.1007/s10237-024-01913-8","DOIUrl":"https://doi.org/10.1007/s10237-024-01913-8","url":null,"abstract":"We propose a robust framework for quantitatively comparing model-predicted and experimentally measured strain fields in the human brain during harmonic skull motion. Traumatic brain injuries (TBIs) are typically caused by skull impact or acceleration, but how skull motion leads to brain deformation and consequent neural injury remains unclear and comparison of model predictions to experimental data remains limited. Magnetic resonance elastography (MRE) provides high-resolution, full-field measurements of dynamic brain deformation induced by harmonic skull motion. In the proposed framework, full-field strain measurements from human brain MRE in vivo are compared to simulated strain fields from models with similar harmonic loading. To enable comparison, the model geometry and subject anatomy, and subsequently, the predicted and measured strain fields are nonlinearly registered to the same standard brain atlas. Strain field correlations ( <math><msub><mi>C</mi> <mi>v</mi></msub> </math> ), both global (over the brain volume) and local (over smaller sub-volumes), are then computed from the inner product of the complex-valued strain tensors from model and experiment at each voxel. To demonstrate our approach, we compare strain fields from MRE in six human subjects to predictions from two previously developed models. Notably, global <math><msub><mi>C</mi> <mi>v</mi></msub> </math> values are higher when comparing strain fields from different subjects ( <math><msub><mi>C</mi> <mi>v</mi></msub> </math> ~0.6-0.7) than when comparing strain fields from either of the two models to strain fields in any subject. The proposed framework provides a quantitative method to assess similarity (and to identify discrepancies) between model predictions and experimental measurements of brain deformation and thus can aid in the development and evaluation of improved models of brain biomechanics.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding complex transport patterns in flow-induced autologous chemotaxis of multicellular systems.

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-12-05 DOI: 10.1007/s10237-024-01905-8

Aditya Shankar Paspunurwar, Hector Gomez

{"title":"Decoding complex transport patterns in flow-induced autologous chemotaxis of multicellular systems.","authors":"Aditya Shankar Paspunurwar, Hector Gomez","doi":"10.1007/s10237-024-01905-8","DOIUrl":"https://doi.org/10.1007/s10237-024-01905-8","url":null,"abstract":"Cell migration via autologous chemotaxis in the presence of interstitial fluid flow is important in cancer metastasis and embryonic development. Despite significant recent progress, our understanding of flow-induced autologous chemotaxis of multicellular systems remains poor. The literature presents inconsistent findings regarding the effectiveness of collective autologous chemotaxis of densely packed cells under interstitial fluid flow. Here, we present a high-fidelity computational model to analyze the migration of multicellular systems performing autologous chemotaxis in the presence of interstitial fluid flow. Our simulations show that the details of the complex transport dynamics of the chemoattractant and fluid flow patterns that occur in the extracellular space, previously overlooked, are essential to understand this cell migration mechanism. We find that, although flow-induced autologous chemotaxis is a robust migration mechanism for individual cells, the cell-cell interactions that occur in multicellular systems render autologous chemotaxis an inefficient mechanism of collective cell migration. Our results offer new perspectives on the potential role of autologous chemotaxis in the tumor microenvironment, where fluid flow is an important modulator of transport.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semi-automated pipeline for generating personalised cerebrovascular models. 生成个性化脑血管模型的半自动化管道。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-11-27 DOI: 10.1007/s10237-024-01908-5

Alireza Sharifzadeh-Kermani, Jiantao Shen, Finbar Argus, Sergio Dempsey, Jethro Wright, Eryn Kwon, Samantha Holdsworth, Gonzalo Maso Talou, Soroush Safaei

{"title":"Semi-automated pipeline for generating personalised cerebrovascular models.","authors":"Alireza Sharifzadeh-Kermani, Jiantao Shen, Finbar Argus, Sergio Dempsey, Jethro Wright, Eryn Kwon, Samantha Holdsworth, Gonzalo Maso Talou, Soroush Safaei","doi":"10.1007/s10237-024-01908-5","DOIUrl":"https://doi.org/10.1007/s10237-024-01908-5","url":null,"abstract":"Subject-specific cerebrovascular models predict individual unmeasurable vessel haemodynamics using principles of physics, assumed constitutive laws, and measurement-deduced boundary conditions. However, the process of generating these models can be time-consuming, which is a barrier for use in time-sensitive clinical applications. In this work, we developed a semi-automated pipeline to generate anatomically and functionally personalised 0D cerebrovascular models from vasculature geometry and blood flow data. The pipeline extracts the vessel connectivity and geometric parameters from vessel segmentation to automatically generate a bond graph-based (linear and time-dependent) model of subject vasculature. Then, using a neurofuzzy control scheme, the peripheral resistances of the model are calibrated to minimise the discrepancy between measured and predicted blood flow distributions. We validated the pipeline by generating subject-specific models of the Circle of Willis (CoW) for 10 cases and compared haemodynamic predictions against acquired 4D flow MRI data. The results showed a relative error of <math><mrow><mn>0.25</mn> <mo>±</mo> <mn>0.66</mn> <mo>%</mo></mrow> </math> for flow and <math><mrow><mn>13.87</mn> <mo>±</mo> <mn>18.24</mn> <mo>%</mo></mrow> </math> for pulsatility, with a higher error for smaller vessels. We then demonstrated a use case of the model by simulating the blood flow redistribution during vascular occlusion for different CoW geometries. The results highlighted the benefit of a completely connected CoW to redistribute flow. The modular nature and rapid model generation time of this pipeline make it a promising tool for research and clinical use, where the type and structure of data are variable, and computing resources may be limited.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating nonlinear anisotropic properties of healthy and aneurysm ascending aortas using magnetic resonance imaging. 利用磁共振成像估算健康和动脉瘤升主动脉的非线性各向异性特性。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-11-26 DOI: 10.1007/s10237-024-01907-6

Álvaro T Latorre Molins, Andrea Guala, Lydia Dux-Santoy, Gisela Teixidó-Turà, José Fernando Rodríguez-Palomares, Miguel Ángel Martínez Barca, Estefanía Peña Baquedano

{"title":"Estimating nonlinear anisotropic properties of healthy and aneurysm ascending aortas using magnetic resonance imaging.","authors":"Álvaro T Latorre Molins, Andrea Guala, Lydia Dux-Santoy, Gisela Teixidó-Turà, José Fernando Rodríguez-Palomares, Miguel Ángel Martínez Barca, Estefanía Peña Baquedano","doi":"10.1007/s10237-024-01907-6","DOIUrl":"https://doi.org/10.1007/s10237-024-01907-6","url":null,"abstract":"An ascending aortic aneurysm is an often asymptomatic localized dilatation of the aorta. Aortic rupture is a life-threatening event that occurs when the stress on the aortic wall exceeds its mechanical strength. Therefore, patient-specific finite element models could play an important role in estimating the risk of rupture. This requires not only the geometry of the aorta but also the nonlinear anisotropic properties of the tissue. In this study, we presented a methodology to estimate the mechanical properties of the aorta from magnetic resonance imaging (MRI). As a theoretical framework, we used finite element models to which we added noise to simulate clinical data from real patient geometry and different properties of healthy and aneurysmal aortic tissues collected from the literature. The proposed methodology considered the nonlinear properties, the zero pressure geometry, the heart motion, and the external tissue support. In addition, we analyzed the aorta as a homogeneous material and as a heterogeneous model with different properties for the ascending and descending parts. The methodology was also applied to pre-surgical,in vivo MRI data of a patient who underwent surgery during which an aortic wall sample was obtained. The results were compared with those obtained from ex vivo biaxial test of the patient's tissue sample. The methodology showed promising results after successfully recovering the nonlinear anisotropic material properties of all analyzed cases. This study demonstrates that the variable used during the optimization process can affect the result. In particular, variables such as principal strains were found to obtain more realistic materials than the displacement field.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infant skull fractures align with the direction of bone mineralization. 婴儿颅骨骨折与骨矿化方向一致。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-11-25 DOI: 10.1007/s10237-024-01902-x

Siyuan Chen, Svein Kleiven, Xiaogai Li

{"title":"Infant skull fractures align with the direction of bone mineralization.","authors":"Siyuan Chen, Svein Kleiven, Xiaogai Li","doi":"10.1007/s10237-024-01902-x","DOIUrl":"https://doi.org/10.1007/s10237-024-01902-x","url":null,"abstract":"The geometry and mechanical properties of infant skull bones differ significantly from those of adults. Over the past decades, debates surrounding whether fractures in infants come from deliberate abuse or accidents have generated significant impacts in both legal and societal contexts. However, the etiology of infant skull fractures remains unclear, which motivates this study with two main components of work. Firstly, we present and implement a progressive unidirectional fabric composite damage model for infant cranial vaults to represent ductile and anisotropic properties-two typical mechanical characteristics of infant skulls. Secondly, we hypothesize that these intrinsic material properties cause injuries perpendicular to the fiber direction to dominate infant skull fractures, resulting in fracture lines that align with the direction of mineralization in the infant skull. The material model and the finite element (FE) model were verified hierarchically, and this hypothesis was verified by reconstructing two legal cases with known fall heights and implementing the above damage model into CT-based subject-specific infant FE head models. We discovered that the infant skull is more susceptible to injuries within planes perpendicular to the mineralization direction because of the anisotropic mechanical property caused by the direction of mineralization, leading to infant skull fractures aligning with the mineralization direction. Our findings corroborated the several previously reported observations of fractures on cranial vaults, demonstrating that these fractures were closely associated with sutures and oriented along the mineralization direction, and revealed the underlying mechanisms of infant skull fracture pattern. The modeling methods and results of this study will serve as an anchor point for more rigorous investigations of infant skull fractures, ultimately aiming to provide convincing biomechanical evidence to aid forensic diagnoses of abusive head trauma.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms. 用于治疗颅内动脉瘤的基于形状记忆聚合物泡沫的血管内栓塞装置的 CFD 研究。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-11-25 DOI: 10.1007/s10237-024-01910-x

Tanner L Cabaniss, Ryan Bodlak, Yingtao Liu, Geoffrey P Colby, Hyowon Lee, Bradley N Bohnstedt, Rinaldo Garziera, Gerhard A Holzapfel, Chung-Hao Lee

{"title":"CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.","authors":"Tanner L Cabaniss, Ryan Bodlak, Yingtao Liu, Geoffrey P Colby, Hyowon Lee, Bradley N Bohnstedt, Rinaldo Garziera, Gerhard A Holzapfel, Chung-Hao Lee","doi":"10.1007/s10237-024-01910-x","DOIUrl":"10.1007/s10237-024-01910-x","url":null,"abstract":"The hemodynamic and convective heat transfer effects of a patient-specific endovascular therapeutic agent based on shape-memory polymer foam (SMPf) are evaluated using computational fluid dynamics studies for six patient-specific aneurysm geometries. The SMPf device is modeled as a continuous porous medium with full expansion for the flow studies and with various degrees of expansion for the heat transfer studies. The flow simulation parameters were qualitatively validated based on the existing literature. Further, a mesh independence study was conducted to verify an optimal cell size and reduce the computational costs. For convective heat transfer, a worst-case scenario is evaluated where the minimum volumetric flow rate is applied alongside the zero-flux boundary conditions. In the flow simulations, we found a reduction of the average intra-aneurysmal flow of > 85% and a reduction of the maximum intra-aneurysmal flow of > 45% for all presented geometries. These findings were compared with the literature on numerical simulations of hemodynamic and heat transfer of SMPf devices. The results obtained from this study provide a novel and practical framework for optimizing the design of patient-specific SMPf devices, integrating advanced computational models of hemodynamics and heat transfer. This framework could guide the future development of personalized endovascular embolization solutions for intracranial aneurysms with improved therapeutic outcome.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical modelling infers that collagen content within peripheral nerves is a greater indicator of axial Young's modulus than structure. 生物力学模型推断，外周神经中的胶原蛋白含量比结构更能说明轴向杨氏模量。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-11-25 DOI: 10.1007/s10237-024-01911-w

Eleanor A Doman, Nicholas C Ovenden, James B Phillips, Rebecca J Shipley

{"title":"Biomechanical modelling infers that collagen content within peripheral nerves is a greater indicator of axial Young's modulus than structure.","authors":"Eleanor A Doman, Nicholas C Ovenden, James B Phillips, Rebecca J Shipley","doi":"10.1007/s10237-024-01911-w","DOIUrl":"https://doi.org/10.1007/s10237-024-01911-w","url":null,"abstract":"The mechanical behaviour of peripheral nerves is known to vary between different nerves and nerve regions. As the field of nerve tissue engineering advances, it is vital that we understand the range of mechanical regimes future nerve implants must match to prevent failure. Data on the mechanical behaviour of human peripheral nerves are difficult to obtain due to the need to conduct mechanical testing shortly after removal from the body. In this work, we adapt a 3D multiscale biomechanical model, developed using asymptotic homogenisation, to mimic the micro- and macroscale structure of a peripheral nerve. This model is then parameterised using experimental data from rat peripheral nerves and used to investigate the effect of varying the collagen content, the fibril radius and number density, and the macroscale cross-sectional geometry of the peripheral nerve on the effective axial Young's moduli of the whole nerve. Our results indicate that the total amount of collagen within a cross section has a greater effect on the axial Young's moduli compared to other measures of structure. This suggests that the amount of collagen in a cross section of a peripheral nerve, which can be measured through histological and imaging techniques, is one of the key metrics that should be recorded in the future experimental studies on the biomechanical properties of peripheral nerves.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mechanical response of polymeric gyroid structures in an optimised orthotic insole. 优化矫形鞋垫中聚合物陀螺结构的机械响应。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-11-19 DOI: 10.1007/s10237-024-01912-9

Dayna Cracknell, Mark Battley, Justin Fernandez, Maedeh Amirpour

{"title":"The mechanical response of polymeric gyroid structures in an optimised orthotic insole.","authors":"Dayna Cracknell, Mark Battley, Justin Fernandez, Maedeh Amirpour","doi":"10.1007/s10237-024-01912-9","DOIUrl":"10.1007/s10237-024-01912-9","url":null,"abstract":"This study aims to explore the mechanical behaviour of polymeric gyroid structures under compression within the context of orthotic insoles, focussing on custom optimisation for lower peak plantar pressures. This research evaluates the compressive response of gyroid structures using a combination of experimental testing and numerical modelling. Stereolithography was used to manufacture gyroid samples for experimental tests, and explicit finite element analysis was used to model the gyroid's response numerically. Hyperfoam, first-order polynomial, and second-order polynomial hyperelastic constitutive models were considered to homogenise the mechanical response of the structure. The homogenised properties of the structure were then implemented in an optimisation algorithm to obtain the optimal gyroid structure for a given subject by minimising the standard distribution of plantar pressures. Findings indicate that the compressive response polymeric gyroid structures can be represented with a homogeneous material. The hyperfoam model was chosen due to its accuracy and interpolation quality. The optimisation process successfully identified configurations that maximise the mechanical advantages of gyroid lattices, demonstrating significant improvements in plantar pressure distributions. The optimised insole showed a 30% reduction in the standard deviation of the plantar pressure and a 10% reduction in the peak stress. The optimisation method reduced peak pressures by 12.2 kPa compared to a traditional medium-density Poron orthotic insole, and 94.3 kPa compared barefoot conditions. The mechanical response of gyroid structures has successfully been modelled, analysed and homogenised. The study concludes that custom gyroid-based orthotic insoles offer a promising solution for personalised foot care.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on the mucus dynamics in the human respiratory airway. 人体呼吸道粘液动力学综述。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-11-19 DOI: 10.1007/s10237-024-01898-4

Asma Tufail, Yankun Jiang, Xinguang Cui

{"title":"A review on the mucus dynamics in the human respiratory airway.","authors":"Asma Tufail, Yankun Jiang, Xinguang Cui","doi":"10.1007/s10237-024-01898-4","DOIUrl":"10.1007/s10237-024-01898-4","url":null,"abstract":"Research interest in the dynamics of respiratory flow and mucus has significantly increased in recent years with important contributions from various disciplines such as pulmonary and critical care medicine, surgery, physiology, environmental health sciences, biophysics, and engineering. Different areas of engineering, including mechanical, chemical, civil/environmental, aerospace, and biomedical engineering, have longstanding connections with respiratory research. This review draws on a wide range of scientific literature that reflects the diverse audience and interests in respiratory science. Its focus is on mucus dynamics in the respiratory airways, covering aspects such as mucins in fluidity and network formation, mucus production and function, response to external conditions, clearance methods, relationship with age, rheological properties, mucus surfactant, and mucoviscidosis. Each of these areas contains multiple subtopics that offer extensive depth and breadth for readers. We underscore the crucial importance of regulating and treating mucus for maintaining the health and functionality of the respiratory system, highlighting the ongoing need for further research to address respiratory disorders associated with mucus dynamics.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0