Biomechanics and Modeling in Mechanobiology最新文献

{"title":"A computational model-based study on the mechano-energetic characteristics of the left ventricle with obstructive hypertrophic cardiomyopathy before and after septal myectomy.","authors":"Taiwei Liu, Mi Zhou, Le Qin, Yuqing Tian, Fuyou Liang","doi":"10.1007/s10237-025-02003-z","DOIUrl":"https://doi.org/10.1007/s10237-025-02003-z","url":null,"abstract":"<p><p>Left ventricular outflow tract obstruction (LVOTO) is a representative phenotype of obstructive hypertrophic cardiomyopathy (OHCM). Septal myectomy has been extensively demonstrated as an effective surgery for treating OHCM. However, it remains incompletely understood how the surgery would alter the mechanical and energetic states of the left ventricle (LV). In this study, microstructure-based finite element (FE) models were built for the LVs of two patients with OHCM to compute myocardial mechanics before and after septal myectomy. In addition, energy metrices spanning multiple scales were defined and calculated based on the results of FE analysis. The results showed that septal myectomy facilitated a significant improvement in the mechanical state of the LV, characterized mainly by the overall decreased while more homogeneously distributed myocardial tissue and cardiomyocyte stresses. Energetically, the total mechanical energies at the scales of the entire LV, myocardial tissue, and cardiomyocyte all decreased remarkably after septal myectomy. Moreover, the surgery induced a moderate increase in the efficiencies of mechanical energy conversion at the myocardial tissue and cardiomyocyte levels in the septal region. Although the mechanical and energetic parameters of the LV differed quantitatively between the two patients, they exhibited similar trends of change following septal myectomy. These results suggest that septal myectomy can improve the mechano-energetic state of the LV, and thereby may exert favorable influence on postoperative cardiac remodeling and adaptation. The proposed modeling method may offer a promising means for optimizing surgical planning or evaluating the therapeutic effects of septal myectomy for patients with OHCM.</p>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying the local strain energy density distribution in the mouse tibia: the critical role of the loading direction.","authors":"Saira Mary Farage-O'Reilly, Vee San Cheong, Peter Pivonka, Visakan Kadirkamanathan, Enrico Dall'Ara","doi":"10.1007/s10237-025-02011-z","DOIUrl":"https://doi.org/10.1007/s10237-025-02011-z","url":null,"abstract":"<p><p>Understanding how bone adapts to external forces is fundamental for exploring potential biomechanical interventions against skeletal diseases. This can be studied preclinically, combining in vivo experiments in rodents and in silico mechanoregulation models. While the in vivo tibial loading model is widely used to study bone adaptation, the common assumption of purely axial loading may be a simplification. This study quantifies the effect of the loading direction on the strain energy density (SED) distribution in the mouse tibia, a commonly used input for mechanoregulated bone remodelling models. To achieve this, validated micro-finite element (micro-FE) models were used to test the differences in local SED when the bone was loaded along different loading directions. In vivo micro-computed tomography (micro-CT) images were acquired from the tibiae of eleven ovariectomised mice at 18 weeks old before intervention and at 20 weeks old, after six mice underwent external mechanical loading. Micro-CT-based micro-FE models were generated for each tibia at both time points and loaded with a unit load in each Cartesian direction independently. The results from these unit load models were linearly combined to simulate various loading directions, defined by angles θ (inferior-superior) and ϕ (anterior-posterior). The results revealed a high sensitivity of the mouse tibia to the loading direction across both groups and time points. Several loading directions (e.g., θ = 10°, ϕ = 205-210°) resulted in lower medians of the top 5% SED values compared to those obtained for the nominal axial case (θ = 0°, ϕ = 0°). Conversely, higher values were observed for other directions (e.g., θ = 30°, ϕ = 35-50°). These findings emphasise the importance of considering the loading direction in experimental and computational bone adaptation studies.</p>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart in a knot: unraveling the impact of the nested tori myofiber architecture on ventricular mechanics","authors":"Kasra Osouli,&nbsp;Francesco De Gaetano,&nbsp;Maria Laura Costantino,&nbsp;Mathias Peirlinck","doi":"10.1007/s10237-025-01995-y","DOIUrl":"10.1007/s10237-025-01995-y","url":null,"abstract":"<div><p>The intricate three-dimensional organization of cardiac myofibers and sheetlets plays a critical role in the mechanical behavior of the human heart. Despite extensive research and the development of various rule-based myofiber architecture surrogate models, the precise arrangement of these structures and their impact on cardiac function remain subjects of debate. In this study, we present a novel myofiber architecture surrogate inspired by Streeter’s nested tori conjecture, modeling the left ventricle as a series of smoothly twisting toroidal surfaces populated by continuous myofiber and sheetlet fields. Leveraging high-fidelity cardiac computational modeling approaches, we systematically evaluated the biomechanical performance of this nested tori architecture against conventional rule-based nested ellipsoidal models. Our results demonstrate that the nested tori architecture aligns more closely with experimental data on physiological myofiber and sheetlet angles. Notably, it enhances sheetlet mobility—a key mechanism for effective cardiac pumping—resulting in higher ejection fraction, greater global deformation, and a more physiological wall rotation pattern. Additionally, it produces a more homogeneous myofiber stress distribution and increased myofiber shortening during ejection. These findings suggest that the nested tori architecture provides a compelling alternative to conventional nested ellipsoidal models, offering a more physiologically consistent representation of myocardial structure and its functional implications. By enabling improved biomechanical performance in silico, this approach supports further investigation into how detailed myoarchitectural continuity shapes cardiac function. Ultimately, it may open promising avenues for advancing cardiac diagnosis, guiding the design of bioinspired implants and devices, and deepening our understanding of both healthy and diseased cardiac mechanics.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1815 - 1835"},"PeriodicalIF":2.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01995-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal invagination caused by circumferential contraction with longitudinal relaxation of the wall.","authors":"Hitomi Okino, Hironori Takeda, Shunichi Ishida, Yohsuke Imai","doi":"10.1007/s10237-025-02010-0","DOIUrl":"https://doi.org/10.1007/s10237-025-02010-0","url":null,"abstract":"<p><p>Pediatric intussusception is frequently observed in the ileocecal region, where the terminal ileum invaginates into the colon. Previous studies have indicated an association between pediatric intussusception and inflammation as well as intestinal motility. However, the underlying mechanisms remain unclear, particularly with regard to the mechanics. We hypothesized that invagination occurs when longitudinal and circular smooth muscles are not coordinated during peristalsis. To test the hypothesis from a mechanical perspective, we developed a computational model of the terminal ileum, where the terminal ileum is modeled as a hyperelastic tube. We showed that circumferential contraction with longitudinal relaxation of the hyperelastic tube wall caused invagination in the contracting region of the tube. We also found that invagination occurred when a square-shaped contracting region emerged in the hyperelastic tube. These results indicate that uncoordinated motion of the circular and longitudinal muscles can lead to invagination of the intestinal wall. In addition, the configuration of peristalsis may serve as an indicator of the risk of pediatric intussusception.</p>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherosclerosis increases adventitial pressure and limits solute transport via fluid-balance mechanisms","authors":"Willy V. Bonneuil,&nbsp;Daniel J. Watson,&nbsp;Sarajo K. Mohanta,&nbsp;Andreas J. R. Habenicht,&nbsp;James E. Moore Jr,&nbsp;Jennifer Frattolin","doi":"10.1007/s10237-025-02000-2","DOIUrl":"10.1007/s10237-025-02000-2","url":null,"abstract":"<div><p>The adventitia of blood vessels is their structural interface with surrounding tissues and may also contribute importantly to atherogenesis. Adventitial vasa vasorum and lymphatic vessels provide sources and sinks of interstitial fluid and solutes and remodel in disease. We constructed a mathematical model to investigate how soluble disease mediators, including lipoproteins and cytokines, are transported through the artery wall in healthy and atherosclerotic conditions. We derived model parameters from <i>in vivo</i> measurements where possible and extensively investigated the sensitivity of fluid flow and solute transport to them. Adventitial interstitial fluid pressure is predicted to increase in atherosclerosis because of a shift in transmural fluxes across vasa vasorum and lymphatics. In healthy conditions, 40–80% of the fluid gathered by lymphatics originates from vasa vasorum, and this increases to 60–90% in atherosclerosis. The increased dilution of fluid flowing from the inner layers in atherosclerosis implies that solute transport from the media to the adventitia is impaired. This implies increased concentration gradients near the external elastic lamina that may increase immune-cell retention there, and decreased gradients in the outer adventitia that may reduce immune-cell attraction from there.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1875 - 1893"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-02000-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering dispersion: How robust is automated model discovery for human myocardial tissue?","authors":"Denisa Martonová, Sigrid Leyendecker, Gerhard A Holzapfel, Ellen Kuhl","doi":"10.1007/s10237-025-02005-x","DOIUrl":"https://doi.org/10.1007/s10237-025-02005-x","url":null,"abstract":"<p><p>Computational modeling has become an integral tool for understanding the interaction between structural organization and functional behavior in a wide range of biological tissues, including the human myocardium. Traditional constitutive models, and recent models generated by automated model discovery, are often based on the simplifying assumption of perfectly aligned fiber families. However, experimental evidence suggests that many fiber-reinforced tissues exhibit local dispersion, which can significantly influence their mechanical behavior. Here, we integrate the generalized structure tensor approach into automated material model discovery to represent fibers that are distributed with rotational symmetry around three mean orthogonal directions-fiber, sheet, and normal-by using probabilistic descriptions of the orientation. Using biaxial extension and triaxial shear data from human myocardium, we systematically vary the degree of directional dispersion and stress measurement noise to explore the robustness of the discovered models. Our findings reveal that up to a moderate dispersion in the fiber direction and arbitrary dispersion in the sheet and normal directions improve the goodness of fit and enable recovery of a previously proposed four-term model in terms of the isotropic second invariant, two dispersed anisotropic invariants, and one coupling invariant. Our approach demonstrates strong robustness and consistently identifies similar model terms, even in the presence of up to 7% random noise in the stress data. In summary, our study suggests that automated model discovery based on the powerful generalized structure tensors is robust to noise and captures microstructural uncertainty and heterogeneity in a physiologically meaningful way.</p>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical study on low-density lipoprotein transport in intracranial aneurysms and its association with wall enhancement.","authors":"Yuqing Tian, Jianjian Zhang, Huilin Zhao, Xiao Li, Fuyou Liang","doi":"10.1007/s10237-025-02004-y","DOIUrl":"https://doi.org/10.1007/s10237-025-02004-y","url":null,"abstract":"<p><p>The frequent detection of wall enhancement by vessel wall imaging in unstable or ruptured intracranial aneurysms (IAs) implies the potential involvement of blood substance transport in the pathogenesis of IAs. In this study, we developed a new method for simulating the transport of low-density lipoprotein (LDL) in IAs. The method was characterized by the coupled solution of LDL transport behaviors in lumen, across endothelium, and within vessel wall, and the incorporation of a sub-model that accounts for the combined effect of wall shear stress (WSS) magnitude and oscillatory shear index (OSI) on endothelial permeability to LDL. Numerical simulations were conducted on the IAs of four patients with clinically confirmed wall enhancement status. Obtained results demonstrated the propensity of IAs for enhanced LDL deposition on the lumen surface and LDL accumulation within the wall compared to normal cerebral arteries. Notably, the spatial distributions of high LDL concentration on the lumen surface and within the vessel wall were not always consistent, indicating regional variations in biomechanical factors facilitating intraluminal retention and transmural transport of LDL. Furthermore, the IAs with wall enhancement exhibited remarkably larger area ratios of wall regions exposed to high LDL concentration than those without wall enhancement. Relatively, the area ratios of low WSS and high OSI were less predictive of aneurysm wall enhancement. These findings underscore the potential value of investigating mass transport over general hemodynamic behaviors in classifying the pathological state or assessing the risk of IAs.</p>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Achilles tendon adaptation to mechanical load: a computational model integrating collagen fibre orientation heterogeneity.","authors":"Renate Janssen, Anna Gustafsson, Viktor Jönsson, Lorenzo Grassi, Maria Pierantoni, Hanna Isaksson","doi":"10.1007/s10237-025-02002-0","DOIUrl":"https://doi.org/10.1007/s10237-025-02002-0","url":null,"abstract":"<p><p>Tendons are known to adapt their structural and mechanical properties in response to mechanical loading, but the precise mechanisms underlying this adaptation remain poorly understood. A previous study on rat Achilles tendons compared the effect of unloading (Botox injections and orthosis) with free cage activity (full loading) and revealed that unloading impaired the mechanical response and resulted in more dispersed collagen fibre orientations. The current study investigates tendon mechanobiology by integrating this experimental fibre data into a finite element model. The aim is to evaluate whether the altered mechanical response after unloading results from changes in collagen fibre orientation, tendon geometry, or material properties. Collagen fibre orientation analysis was performed based on phase-contrast enhanced synchrotron X-ray tomography images. Two levels of collagen fibre orientation detail were implemented into the finite element model: 1) global fibre orientation analysis that averaged fibre directions across the entire tendon and 2) local orientation analysis that introduced spatial heterogeneity by incorporating element-specific fibre distributions. Our results indicate that the impaired mechanical response in unloaded tendons is mainly due to changes in fibre orientation distribution and geometry. The local collagen orientation analysis showed a lower overall force response, but did not alter the relative differences between fully loaded and unloaded tendons. Incorporating the increased heterogeneity may still be important for future studies of tendon mechanobiology. The established framework provides a robust tool for exploring tendon biomechanics, capturing detailed fibre information, and offering valuable insights into tendon adaptation under various conditions.</p>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of stem migration after total hip replacement","authors":"Marlis Reiber,&nbsp;Fynn Bensel,&nbsp;Nils Becker,&nbsp;Stefan Budde,&nbsp;Udo Nackenhorst","doi":"10.1007/s10237-025-01985-0","DOIUrl":"10.1007/s10237-025-01985-0","url":null,"abstract":"<div><p>After total hip replacement, the primary and secondary implant stability is critical to ensure long-term success. Excessive migration of the femoral stem can cause implant loosening. In this work, a novel approach for the simulation of the femoral stem migration using the finite element method is presented. Currently, only a few mostly contact-based models exist for this purpose. Instead, a bio-active interface model is used for the bone-stem interface which transforms from the Drucker–Prager to the von Mises plasticity criterion during the osseointegration process. As the position of the implant generally stabilises within one week after the implantation, the migration and osseointegration simulations are decoupled. To understand the effects on the migration, various parameter combinations are examined and a sensitivity analysis is performed. The results indicate that the joint force and the adhesion parameter have the most substantial influence on the migration. Furthermore, the influence of the migration on the subsequent osseointegration process is explored for a numerical example. The proposed model is able to depict the femoral stem migration with values up to 0.27 mm, which are in the order of magnitude of clinically observed values. Further, the model is provided as an open-source Abaqus user material subroutine. Numerical simulation of the stem migration could assist in clinical decision-making by identifying optimal parameter combinations to improve implant stability.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1619 - 1631"},"PeriodicalIF":2.7,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01985-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of bone remodeling induced by swelling anchors considering heterogeneous properties.","authors":"Amirreza Sadighi, Mehrangiz Taheri, Nolan Black, Jordan Stolle, Moein Taghvaei, Madeline Boyes, Sorin Siegler, Thomas P Schaer, Ahmad R Najafi","doi":"10.1007/s10237-025-02001-1","DOIUrl":"https://doi.org/10.1007/s10237-025-02001-1","url":null,"abstract":"<p><p>This study explored the biomechanical behavior of co-polymeric swelling bone anchors and their bone remodeling induction using finite element analysis of a model with heterogeneous properties. First, a hygro-elastic finite element framework was developed to capture the swelling of the bone anchors over time by moisture gain, validated against the data from free swelling experiments. Afterward, finite element models were developed using micro-CT data to capture heterogeneous material properties, and finally, bone remodeling induced by the swelling, acting as a mechanical stimulus, was investigated. The study examined three co-polymeric ratios of methyl methacrylate and acrylic acid (MMA/AA)-80/20, 85/15, and 90/10-and assessed the impact of their associated swelling ratios on bone remodeling and fixation strength. Moreover, in parallel with the numerical investigations, an in vivo study using a sheep model was conducted to evaluate the biocompatibility of these anchors and bone remodeling response to the swelling. The numerical findings highlighted the importance of optimizing swelling ratios to enhance mechanical engagement without causing adverse resorption. More specifically, the results demonstrated that bone regeneration in the region of interest is highly sensitive to the swelling ratio. When the swelling is maintained within an optimal range-such as in the 85/15 composition-favorable densification occurs at the bone-implant interface, enhancing osteointegration. In contrast, excessive swelling (e.g., the 80/20 composition) induces localized overload resorption due to elevated stress concentrations at the interface, which may compromise implant success. Additionally, correlations found between the numerical and in vivo study outcomes supported the notion of an optimal swelling threshold and confirmed the predictive capabilities of the developed hygro-elastic finite element framework. To underscore the importance of favorable bone remodeling in the interface, a push-out study was performed to analyze the fixation strength prior and subsequent to bone remodeling. The significant difference in push-out forces before and after remodeling demonstrates that bone densification at the interface can substantially enhance fixation strength.</p>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}