Biomechanics and Modeling in Mechanobiology最新文献_第3页

From structure to mechanics: exploring the role of axons and interconnections in anisotropic behavior of brain white matter. 从结构到力学：探索轴突和相互连接在脑白质各向异性行为中的作用。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-04-28 DOI: 10.1007/s10237-025-01957-4

Fatemeh Atashgar, Mehdi Shafieian, Nabiollah Abolfathi

{"title":"From structure to mechanics: exploring the role of axons and interconnections in anisotropic behavior of brain white matter.","authors":"Fatemeh Atashgar, Mehdi Shafieian, Nabiollah Abolfathi","doi":"10.1007/s10237-025-01957-4","DOIUrl":"10.1007/s10237-025-01957-4","url":null,"abstract":"According to various experimental studies, the role of axons in the brain's white matter (WM) is still a subject of debate: Is the role of axons in brain white matter (WM) limited to their functional significance, or do they also play a pivotal mechanical role in defining its anisotropic behavior? Micromechanics and computational models provide valuable tools for scientists to comprehend the underlying mechanisms of tissue behavior, taking into account the contribution of microstructures. In this review, we delve into the consideration of strain level, strain rates, and injury threshold to determine when WM should be regarded as anisotropic, as well as when the assumption of isotropy can be deemed acceptable. Additionally, we emphasize the potential mechanical significance of interconnections between glial cells-axons and glial cells-vessels. Moreover, we elucidate the directionality of WM stiffness under various loading conditions and define the possible roles of microstructural components in each scenario. Ultimately, this review aims to shed light on the significant mechanical contributions of axons in conjunction with glial cells, paving the way for the development of future multiscale models capable of predicting injuries and facilitating the discovery of applicable treatments.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":"779-810"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational construction and design optimization of a novel tri-tube heart valve. 新型三管心脏瓣膜的计算构造与设计优化。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1007/s10237-025-01956-5

Jirong Li, Yijiang Yu, Robert T Tranquillo

{"title":"Computational construction and design optimization of a novel tri-tube heart valve.","authors":"Jirong Li, Yijiang Yu, Robert T Tranquillo","doi":"10.1007/s10237-025-01956-5","DOIUrl":"10.1007/s10237-025-01956-5","url":null,"abstract":"A finite-element-based algorithm for the in silico construction of a novel tri-tube heart valve was developed to facilitate optimization of the leaflet geometry. An anisotropic hyperelastic model fitted to high-strain rate planar equibiaxial tension and compression data was used to approximate the nonlinear and anisotropic material behavior of biologically-engineered tubes and simulate valve closure under steady back pressure and steady forward flow. Four metrics were considered to evaluate valve performance in simulated closure: coaptation area, regurgitation area, pinwheel index, and prolapse area. Response surfaces revealed competing objectives between metrics for a valve of target 24 mm diameter in terms of two design parameters, tube diameter and leaflet height. A multi-objective genetic algorithm determined an intermediate tube diameter and leaflet height (16 mm and 11 mm, respectively) of the design space as optimal. Additionally, steady flow simulations were performed using two-way fluid-structure interaction with selected designs to examine washout behind leaflets with particle tracking. One design close to the optimal point for valve closure indicated washout for particles initially distributed behind leaflets. Though comprehensive valve design optimization requires flow analysis over multiple valve cycles to capture all effects associated with flow, this methodology based on diastolic state geometry optimization followed by steady washout analysis reduces the space of design variables for further optimization.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":"1103-1121"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smooth leaflets with curved belly and attachment edge profiles promote adaptive remodeling in tissue-engineered heart valves: an in silico study. 具有弯曲腹部和附着边缘轮廓的光滑小叶促进组织工程心脏瓣膜的适应性重塑：一项计算机研究。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-04-04 DOI: 10.1007/s10237-025-01937-8

Valery L Visser, Sarah E Motta, Simon P Hoerstrup, Frank P T Baaijens, Sandra Loerakker, Maximilian Y Emmert

{"title":"Smooth leaflets with curved belly and attachment edge profiles promote adaptive remodeling in tissue-engineered heart valves: an in silico study.","authors":"Valery L Visser, Sarah E Motta, Simon P Hoerstrup, Frank P T Baaijens, Sandra Loerakker, Maximilian Y Emmert","doi":"10.1007/s10237-025-01937-8","DOIUrl":"10.1007/s10237-025-01937-8","url":null,"abstract":"Tissue-engineered heart valves (TEHVs) are promising valve replacements due to their potential to regenerate into living heart valves, capable of growth and adaptation. Previous TEHVs showed promising results, but often developed progressive leaflet retraction in the long term. In a prior proof-of-concept study, we demonstrated that a novel geometry with more native-like mechanical behavior could give rise to more adaptive remodeling, thereby minimizing leaflet retraction in vivo. In the current study, we aimed to systematically analyze the impact of TEHV geometry on in vivo remodeling under both pulmonary and aortic conditions. Using a bio-inspired in silico framework, we predicted cell-driven, mechano-mediated remodeling in TEHVs post-implantation. Two parameterized valve designs were evaluated under both pulmonary and aortic pressure conditions. The results indicate that a valve design with smooth leaflets, a curved belly profile, and medium to wide attachment edge effectively minimizes stress concentrations and reduces the risk of valve insufficiency in both conditions. Additionally, this design should be tailored to specific hemodynamic conditions to prevent retraction in pulmonary applications and excessive stress concentrations in aortic applications. These insights provide essential guidelines for optimizing TEHV designs, aiming to promote functional remodeling and maintain valve functionality over time, thereby advancing the development of next-generation TEHVs with enhanced long-term outcomes.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":"811-828"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on finite element modelling of finger and hand mechanical behaviour in haptic interactions. 触觉交互中手指和手力学行为的有限元建模研究进展。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1007/s10237-025-01943-w

Gianmarco Cei, Alessio Artoni, Matteo Bianchi

{"title":"A review on finite element modelling of finger and hand mechanical behaviour in haptic interactions.","authors":"Gianmarco Cei, Alessio Artoni, Matteo Bianchi","doi":"10.1007/s10237-025-01943-w","DOIUrl":"10.1007/s10237-025-01943-w","url":null,"abstract":"Touch perception largely depends on the mechanical properties of the soft tissues of the glabrous skin of fingers and hands. The correct modelling of the stress-strain state of these tissues during the interaction with external objects can provide insights on the exteroceptual mechanisms of human touch, offering design guidelines for artificial haptic systems. However, devising correct models of the finger and hand at contact is a challenging task, due to the biomechanical complexity of human skin. This work presents an overview of the use of Finite Element analysis for studying the stress-strain state in the glabrous skin of the hand, under different loading conditions. We summarize existing approaches for the design and validation of Finite Element models of the soft tissues of the human finger and hand, evaluating their capability to provide results that are valuable in understanding tactile perception. The goal of our work is to serve as a reference and provide guidelines for those approaching this modelling method for the study of human haptic perception.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":"895-917"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical characterization and constitutive law of porcine urethral tissues: a hyperelastic fiber model based on a physical approach. 猪尿道组织的力学特性和本构规律：基于物理方法的超弹性纤维模型。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI: 10.1007/s10237-025-01951-w

Quentin De Menech, Andres Osorio Salazar, Quentin Bourgogne, Yoan Civet, Adrien Baldit, Yves Perriard

{"title":"Mechanical characterization and constitutive law of porcine urethral tissues: a hyperelastic fiber model based on a physical approach.","authors":"Quentin De Menech, Andres Osorio Salazar, Quentin Bourgogne, Yoan Civet, Adrien Baldit, Yves Perriard","doi":"10.1007/s10237-025-01951-w","DOIUrl":"10.1007/s10237-025-01951-w","url":null,"abstract":"Lower urinary tract symptoms (LUTS), particularly urinary incontinence (UI), represent a significant global health challenge, affecting millions of patients worldwide. The artificial urinary sphincter (AUS) remains one of the most effective intervention for severe UI, with its design relying on a detailed understanding of the urethral biomechanics. Given the ethical and logistical constraints of using human tissue, porcine urethras, which share anatomical and mechanical similarities with human urethras, are widely employed in preclinical studies. This study investigates the uniaxial mechanical characterization of porcine urethral tissue under controlled conditions. Fresh porcine urethral samples were subjected to uniaxial tensile testing along both the longitudinal and circumferential directions to characterize their anisotropic mechanical properties. Experimental results were compared with existing datasets to validate findings. Additionally, conventional hyperelastic models were assessed to fit experimental results, and a novel anisotropic constitutive model with physical parameters was developed. This fiber model, which incorporates fiber modulus, volume, and orientation, uses a single set of parameters to predict behavior in both directions. It demonstrated improved accuracy, reaching the performance of the Gasser-Ogden-Holzapfel (GOH) model, with root mean square errors (RMSEs) of 9.24% and 12.98% in the circumferential and longitudinal directions, respectively. In contrast, the Yeoh and Ogden models were unable to fit both directions using a single set of parameters, yielding RMSEs values exceeding 30%. With its enhanced physical relevance, the fiber model having a more physical meaning holds promise for applications in the biomechanical analysis of fiber-composed soft tissues.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":"1031-1042"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A reduced 3D-0D fluid-structure interaction model of the aortic valve that includes leaflet curvature. 包含小叶曲率的主动脉瓣三维流固耦合模型。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 DOI: 10.1007/s10237-025-01960-9

Ivan Fumagalli, Luca Dede', Alfio Quarteroni

{"title":"A reduced 3D-0D fluid-structure interaction model of the aortic valve that includes leaflet curvature.","authors":"Ivan Fumagalli, Luca Dede', Alfio Quarteroni","doi":"10.1007/s10237-025-01960-9","DOIUrl":"https://doi.org/10.1007/s10237-025-01960-9","url":null,"abstract":"We introduce an innovative lumped-parameter model of the aortic valve, designed to efficiently simulate the impact of valve dynamics on blood flow. Our reduced model includes the elastic effects associated with the leaflets' curvature and the stress exchanged with the blood flow. The introduction of a lumped-parameter model based on momentum balance entails an easier calibration of the model parameters: Phenomenological-based models, on the other hand, typically have numerous parameters. This model is coupled to 3D Navier-Stokes equations describing the blood flow, where the moving valve leaflets are immersed in the fluid domain by a resistive method. A stabilized finite element method with a BDF time scheme is adopted for the discretization of the coupled problem, and the computational results show the suitability of the system in representing the leaflet motion, the blood flow in the ascending aorta, and the pressure jump across the leaflets. Both physiological and stenotic configurations are investigated, and we analyze the effects of different treatments for the leaflet velocity on the blood flow.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cellular-meso-macro three-scale approach captures remodelling of cancellous bone in health and disease. 细胞-中观-宏观三尺度方法捕获健康和疾病中松质骨的重塑。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-05-03 DOI: 10.1007/s10237-025-01948-5

Areti Papastavrou, Peter Pivonka, Ina Schmidt, Paul Steinmann

{"title":"A cellular-meso-macro three-scale approach captures remodelling of cancellous bone in health and disease.","authors":"Areti Papastavrou, Peter Pivonka, Ina Schmidt, Paul Steinmann","doi":"10.1007/s10237-025-01948-5","DOIUrl":"10.1007/s10237-025-01948-5","url":null,"abstract":"Remodelling of cancellous bone due to the combined activity of osteoclasts and osteoblasts at the cellular scale has notable repercussions both at the meso (tissue) as well as the macro (organ) scale. At the meso scale, trabeculae adapt their geometry, typically in terms of their cross section, whereas the nominal bone density evolves at the macro scale, all in response to habitual mechanical loading and its perturbations. To capture this intricate scale coupling, we here propose a novel conceptual three-scale approach to the remodelling of cancellous bone. Therein, we combine a detailed bone cell population model at the cellular scale with an idealised trabecular truss network model with adaptive cross sections, that are driven by the cell population model, at the meso scale, which is eventually upscaled to a continuum bone density adaption model at the macro scale. Algorithmically, we solve the meso and macro problems concurrently within a finite element setting and update the cell activity in a staggered fashion. Our benchmark simulations demonstrate the applicability and effectivity of the three-scale approach to analyse bone remodelling in health and disease (here exemplified for the example of osteoporosis) with rich details, e.g. evolving anisotropy, resolved at each scale.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":"975-998"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress analysis method for ascending aortic aneurysm based on unloaded geometry with non-uniform thickness distribution. 基于非均匀厚度分布的卸载几何的升主动脉瘤应力分析方法。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-04-07 DOI: 10.1007/s10237-025-01949-4

Xiaoyu Liu, Zhihong Lin, Shihua Zhao, Fei Li, Qi Gao

{"title":"Stress analysis method for ascending aortic aneurysm based on unloaded geometry with non-uniform thickness distribution.","authors":"Xiaoyu Liu, Zhihong Lin, Shihua Zhao, Fei Li, Qi Gao","doi":"10.1007/s10237-025-01949-4","DOIUrl":"10.1007/s10237-025-01949-4","url":null,"abstract":"Using finite element method (FEM) to compute wall stress is now a common way to assess ascending thoracic aortic aneurysms (ATAA) severity. Medical images can provide aortic geometry for FEM, but thickness information is lacked and the geometry is at loaded state. Therefore, in this study, an unloaded geometry with a non-uniform thickness distribution is reconstructed. Measurements of wall thickness are taken from resected tissue to accurately replicate the thickness distribution. Subsequently, a novel method, derived from the existing fixed-point iterative (FPI) approach, is developed and applied to estimate the unloaded aortic geometry. This new method involves updating the relaxation factor at each iteration to improve robustness by constraining it within a threshold and normalizing it. Compared to the traditional FPI method, this novel approach is better tailored to the aortic geometries examined in this study. The study compares stress results obtained from models with uniform and non-uniform aortic wall thickness, both with and without assuming unloaded conditions. Findings indicate that stress distribution of non-uniform geometry matches better to the measured damage extent. Stress distribution of unloaded geometry is similar to that of loaded geometry, while the use of unloaded geometry enhances the stress gradient. The stress analysis reveals variations across different directions and regions, with the second principal stress (SPS) magnitude that is more sensitive to the circumferential region than the first principal stress (FPS) and von Mises stress (VMS). There is an overlap area between the high SPS region and the most expanded region. The most dilated area usually matched with high SPS region for loaded and unloaded geometry or uniform and non-uniform geometry. Thus, although magnitude of SPS is smaller than that of FPS and of VMS, it is suggested to pay more attention to SPS in severity assessment of ATAA aneurysm.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":"999-1015"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in computational modeling of cytokine and growth factor dynamics in bone healing: a scoping review. 骨愈合过程中细胞因子和生长因子动态计算建模的进展：范围综述。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-03-14 DOI: 10.1007/s10237-025-01938-7

Ahmad Hedayatzadeh Razavi, Nazanin Nafisi, Maria Velasquez-Hammerle, Mohammad Javad Shariyate, Mohammad Khak, Alireza Mirahmadi, Megan McNichol, Edward K Rodrogiuez, Ara Nazarian

{"title":"Advances in computational modeling of cytokine and growth factor dynamics in bone healing: a scoping review.","authors":"Ahmad Hedayatzadeh Razavi, Nazanin Nafisi, Maria Velasquez-Hammerle, Mohammad Javad Shariyate, Mohammad Khak, Alireza Mirahmadi, Megan McNichol, Edward K Rodrogiuez, Ara Nazarian","doi":"10.1007/s10237-025-01938-7","DOIUrl":"10.1007/s10237-025-01938-7","url":null,"abstract":"Bone healing is a complex process regulated by intricate biological and mechanical factors and spatially varied regions over time. This scoping review synthesizes current computational models that incorporate cytokines and growth factors, examining their role in bone healing. Through a systematic analysis of 71 studies, this review identifies and categorizes the modeling methodologies used, including mathematical, finite element, agent-based, mechanobiological, pharmacobiological, and hybrid approaches. The findings highlight the predominant use of mathematical models while noting a recent shift toward more sophisticated techniques like finite element and agent-based models. Key cytokines and growth factors, such as TGF-β, RANK-RANKL-OPG, and PTH, are repeatedly used, underscoring their essential roles in regulating cellular processes. This review also analyzes parameter selection and validation strategies, identifying gaps in current practices and emphasizing the need for high-quality experimental validation to improve model reliability. Some bibliometric analyses provide insights into citation networks and keyword co-occurrence, illustrating influential studies in the field and central themes. The findings offer a foundation for future research to enhance model accuracy, aiming toward more predictive and clinically relevant models accounting for biology and mechanics in bone healing.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":"761-778"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of anisotropic mechanical response of human skin: insights from a clinical trial. 评估人体皮肤的各向异性机械反应：来自临床试验的见解。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-06-02 DOI: 10.1007/s10237-025-01955-6

Aflah Elouneg, Arnaud Lejeune, Gwenaël Rolin, Thomas Lihoreau, Brice Chatelain, Stéphane Bordas, Emmanuelle Jacquet, Jérôme Chambert

{"title":"Assessment of anisotropic mechanical response of human skin: insights from a clinical trial.","authors":"Aflah Elouneg, Arnaud Lejeune, Gwenaël Rolin, Thomas Lihoreau, Brice Chatelain, Stéphane Bordas, Emmanuelle Jacquet, Jérôme Chambert","doi":"10.1007/s10237-025-01955-6","DOIUrl":"10.1007/s10237-025-01955-6","url":null,"abstract":"This paper presents findings from the SKin Uncertainties Modeling (SKUM) clinical trial aimed at assessing the anisotropic mechanical response of human skin using the annular suction test, employing a numerical method and a commercial device, CutiScan® CS 100. A cohort of 30 healthy volunteers participated in the trial, undergoing in vivo testing on the left forearm through a multi-axial stretch induced by ring suction. Determination of the anisotropy axis was performed using a numerical method based on model fitting of experimental data obtained from oriented elliptic curves, which resulted from the radial deformation of circles. The study evaluates the reproducibility and variability of measurements through an intra-subject study involving five participants, providing insights into the consistency of results within individuals. Additionally, an inter-subject analysis across all subjects offers a comprehensive understanding of anisotropy variability, elucidating broader population tendencies. Furthermore, the study explores correlations between anisotropy and demographic factors such as sex, age, and skin thickness, shedding light on potential influences on skin biomechanics. The analysis showed significant correlations between skin anisotropy and sex, with males displaying a distinct anisotropy axis orientation compared to females. In contrast, no significant associations were found between anisotropy and age among individuals aged 20-50, or between anisotropy and epidermal thickness.","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":"1085-1102"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0