Biomechanics and Modeling in Mechanobiology最新文献

{"title":"Development, characterization, and curve fitting of rate-dependent models of calcified cerebral embolus analogs for acute ischemic stroke","authors":"Jose L. Monclova,&nbsp;Daniel J. Walsh,&nbsp;Madelyn E. Hummel,&nbsp;Sophia Weatherwax,&nbsp;Francesco Costanzo,&nbsp;Scott D. Simon,&nbsp;Keefe B. Manning","doi":"10.1007/s10237-025-01997-w","DOIUrl":"10.1007/s10237-025-01997-w","url":null,"abstract":"<div><p>Acute ischemic stroke (AIS) is a leading cause of death worldwide. In recent years, several studies have characterized the material properties of clot types that were removed from stroke patients, showing a highly nonlinear, asymmetric behavior in compression and tension. However, little is still known about the clot phenotype underlying complications in endovascular thrombectomy (EVT). In this study, we propose a spectrum of clot surrogates for highly stiff, red blood cell-rich, aged, calcified clots that may underpin the outcomes of AIS procedures, often called ‘hyperdense middle cerebral artery signs’ by clinicians. This study aims to characterize the high-strain, rate-dependent mechanical properties of a broad range of aged and calcified clot analogs. Blood from healthy donors was used to form aged and calcified clots, which were subjected to rate-dependent uniaxial testing and structural analyses. A method for curve fitting standard linear solids with multiple hyperelastic elements is considered, and a subsequent procedure is outlined for fitting rate-dependent data. High-strain clot analog peak stresses and moduli are on the same order of magnitude as previous studies, with the hypercalcified clots nearly an order of magnitude stiffer than previously recorded. The calcification was shown to be time dependent, as the longer the clots incubated in the calcium solutions, the stiffer they became. SEM images show drastic changes in clot morphology, with mineral nucleation evident around all components of the clot. The curve fitting produced parameters for a host of models that can be used in numerical implementation. The authors note that when curve fitting, energy state of the system should be taken into consideration, in addition to the minimization of the relative error. We demonstrate a wide spectrum of clot properties that are captured well by rate-dependent models for the full dataset, the compressive data, and the tensile data. In this study, we provide a method for creating and characterizing hypercalcified clot analogs as surrogates for the clot phenotype underlying EVT complications. The library of clot properties reported here can be used in numerical simulations, with careful considerations of the curve fitting methods that are employed. These data highlight the need for further investigation into this clot phenotype, which may be related to the subset of AIS patients where clots are unable to be removed.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1855 - 1874"},"PeriodicalIF":2.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanobiology of gastric needle insertions: a combined experimental and numerical study","authors":"Sif Julie Friis,&nbsp;Torben Strøm Hansen,&nbsp;Mette Poulsen,&nbsp;Peter Helding Kvist,&nbsp;Ansgar Petersen,&nbsp;Hans Gregersen,&nbsp;Jens Vinge Nygaard","doi":"10.1007/s10237-025-01986-z","DOIUrl":"10.1007/s10237-025-01986-z","url":null,"abstract":"<div><p>The rising use of biologic drugs has increased the demand for alternative gastric administration methods. Inception of devices engineered to insert medication into the mucosal lining overcomes limitations of traditional administration methods. Mechanical forces from such microneedle insertions can affect tissue and cellular behavior, particularly mechanotransduction markers. This study investigates the effects of needle insertion in gastric tissue to inform the design of alternative drug delivery devices. Experimental and computational approaches were utilized, using tension and radial compression tests on porcine gastric tissue to inform a finite element analysis (FEA) model. This model was validated with atomic force microscopy (AFM)-based micro-indentation to examine stiffness variations near the insertion site, and yes-associated-protein-1 (YAP-1) expression was analyzed to assess cellular mechanotransduction. AFM results revealed a distance-dependent decrease in tissue stiffness from the insertion site (<i>p</i> &lt; 0.05), with significant differences in needle geometry (<i>p</i> &lt; 0.05). The FEA model correlated well with AFM findings, confirming its validity for further cellular simulations. Mechanical stresses from needle insertion were shown to propagate through the tissue, affecting both cytoplasmic and nuclear stress distributions and altering nuclear morphology near the insertion site. The blunt needle produced a higher localized stress field compared to the sharp needle. Additionally, YAP-1 expression was lower in the injected samples than in control samples showing distance-dependent responses observed. This study demonstrates a validated model linking tissue mechanics and cellular responses, highlighting how needle geometry impacts gastric tissue mechanics and mechanotransduction, providing insights essential for designing gastric drug delivery devices.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1633 - 1651"},"PeriodicalIF":2.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01986-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of calcifications on paravalvular leakage by transcatheter aortic valve prostheses: findings from a new in silico clinical trial framework","authors":"Laura Supp,&nbsp;Jan Oldenburg,&nbsp;Matthias Leuchter,&nbsp;Jan Brüning,&nbsp;Claudio Capelli,&nbsp;Alper Öner,&nbsp;Klaus-Peter Schmitz,&nbsp;Michael Stiehm,&nbsp;Finja Borowski","doi":"10.1007/s10237-025-01984-1","DOIUrl":"10.1007/s10237-025-01984-1","url":null,"abstract":"<div><p>Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of severe aortic stenosis, yet paravalvular leakage (PVL) remains a significant complication, associated with increased mortality. Clinical studies have identified correlations between PVL and both anatomical features and calcification patterns. Numerical simulations, particularly patient-specific models, offer valuable insights into PVL, but the limited scale of these studies hinders robust statistical analysis. This study introduces a novel <i>in silico</i> clinical trial (ISCT) framework to investigate the correlation between calcification severity, localization and PVL. For this purpose, a synthetic cohort of calcified aortic roots was generated. A conditional convolutional variational autoencoder was used to create calcification patterns for an existing virtual cohort of the aortic root. The workflow includes finite element analyses for pre-dilation and deployment simulations as well as computational fluid dynamic simulations for PVL calculations of 243 virtual TAVR patients. The results show that the absolute amount of calcification in the device landing zone has no significant influence, but its regional distribution does, especially in the combined leaflet regions. In addition, sinotubular junction diameter, annular eccentricity index, oversizing as well as the combination of aortic angle and calcification in the combined non and left coronary leaflet region influence the occurrence of PVL. This framework not only advances our understanding of PVL mechanisms but also demonstrates the potential of ISCT to complement traditional clinical studies, enabling systematic exploration of complex factors influencing TAVR outcomes.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1605 - 1618"},"PeriodicalIF":2.7,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01984-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling dynamic impact, shock waves, and injury in liver tissue with a constrained mixture theory","authors":"J. D. Clayton","doi":"10.1007/s10237-025-01990-3","DOIUrl":"10.1007/s10237-025-01990-3","url":null,"abstract":"<div><p>A nonlinear continuum theory is advanced for high-rate mechanics and thermodynamics of liver parenchyma. The homogenized continuum is idealized as a solid–fluid mixture of dense viscoelastic tissue and liquid blood. The solid consists of a matrix material comprising the liver lobules and a collagenous fiber network. Under high loading rates pertinent to impact and blast, the velocity difference between solid and fluid is assumed negligible, leading to a constrained mixture theory. The model captures nonlinear isotropic elasticity, viscoelasticity, temperature changes from thermoelasticity and dissipation, and tissue damage, the latter via a scale-free phase-field representation. Effects of blood volume and initial constituent pressures are included. The model is implemented in 3-D finite element software. Analytical and numerical solutions for planar shock loading are compared with observations of liver trauma from shock-tube experiments. Finite-element simulations of dynamic impact are compared with cylinder drop-weight experiments. Model results, including matrix damage exceeding fiber damage at high rates and reduced mechanical stiffness with higher perfused blood volume, agree with experimental trends. Viscoelasticity is important at modest impact speeds.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1735 - 1766"},"PeriodicalIF":2.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-specific numerical simulation of compression therapy effects on interstitial fluid motion in lower limb lymphedema","authors":"Maha Reda,&nbsp;Stéphane Avril","doi":"10.1007/s10237-025-01996-x","DOIUrl":"10.1007/s10237-025-01996-x","url":null,"abstract":"<div><p>Lymphedema is a chronic condition characterized by impaired lymphatic drainage, leading to fluid accumulation, swelling, and progressive tissue remodeling. Compression therapy is the primary treatment used to alleviate swelling and enhance fluid drainage, yet its precise impact on interstitial fluid dynamics remains to be understood. In this study, we developed a poroelastic computational model that simulates fluid flow and tissue deformation in the lower limb under different compression strategies and compression levels. A key feature of our work is the integration of patient-specific geometries, allowing for a more physiologically accurate representation of tissue mechanics and fluid redistribution. We simulated edema formation induced by venous insufficiency by increasing blood capillary pressure from a baseline of 10–80 mmHg, and we observed that interstitial fluid pressure (IFP) increased from a baseline value of 0 mmHg to 8 mmHg, highlighting the impact of vascular dysfunction on fluid accumulation. Simulating complete blockage of lymphatic capillaries resulted in even higher IFP values (40 mmHg) compared to models with functional lymphatics, where IFP remained around 8 mmHg for high capillary pressures, underscoring the critical role of lymphatic drainage. We further showed that an increase in tissue permeability increases gravity-driven fluid pooling, potentially exacerbating swelling in lymphedematous limbs. Additionally, we incorporated an interface pressure derived from Laplace’s law to offer a more realistic estimation of IFP and volume changes, emphasizing its importance for refining compression models and optimizing treatment strategies. These findings contribute to a deeper understanding of compression therapy’s role in interstitial fluid drainage and provide a foundation for improving patient-specific lymphedema management.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1837 - 1854"},"PeriodicalIF":2.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01996-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A three-dimensional computational study of critical pressures of dissection propagation in the aorta","authors":"Sathish Kumar Marimuthu,&nbsp;Giulia Luraghi,&nbsp;Craig Maclean,&nbsp;Robbie Brodie,&nbsp;Francesco Migliavacca,&nbsp;Sean McGinty,&nbsp;Nicholas A. Hill","doi":"10.1007/s10237-025-01991-2","DOIUrl":"10.1007/s10237-025-01991-2","url":null,"abstract":"<div><p>Aortic dissection is a life-threatening disease with high mortality rates. The degradation of the layers of the aorta wall causes tears, which then propagate further due to high-pressure blood penetrating the vessel wall, creating a false lumen. The intimal flap separating the true and false lumen can either bulge inwards constricting the true lumen’s blood flow or bulge outwards leading to catastrophic rupture and internal bleeding. Therefore, to understand the role of critical pressure on tear propagation, a computational study of the initiation and propagation of tears of various sizes and at multiple depths and locations in three-dimensional aortas was conducted. Tears were modelled using the extended finite element method, and the wall of the aortas is an anisotropic hyperelastic material. Blood-pressure-loaded aorta geometries were obtained from the corresponding unloaded geometries using an iterative procedure to match the in vivo geometries. Pressure-driven tear initiation and propagation were studied. Our results show that when the tear surface’s normal is perpendicular to the blood flow, the critical pressure required to cause further propagation is higher for the shorter and deeper tears and reduces when the initial tear size increases. When the normal is parallel to the blood flow, the difference in critical pressure with an increase in tear depth is small and is more likely to propagate transversely. Also, the critical pressure decreases with an increase in the diameter of the aorta for all the tear orientations. This study concludes that tear size, depth inside the medial layer and the diameter of the aorta near the tear location are critical parameters in assessing the risk of further propagation.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1767 - 1780"},"PeriodicalIF":2.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01991-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary mechanical interactions. Insights from an anatomically detailed arterial-venous network model","authors":"Caterina Dalmaso,&nbsp;Pablo Javier Blanco,&nbsp;Lucas Omar Müller","doi":"10.1007/s10237-025-01987-y","DOIUrl":"10.1007/s10237-025-01987-y","url":null,"abstract":"<div><p>We present a 1D-0D model that couples a 0D description of lung mechanics to the closed-loop Anatomically-Detailed Arterial-Venous Network (ADAVN) model. We show that our model can satisfactorily reproduce a set of cardiovascular indices of interest observed in healthy young males at rest. Next, we assess the impact of respiration on cardiac performance and on the periodicity and average values of pressure and flow waveforms in different vascular districts. In particular, our results confirm that respiration has a fundamental pumping function, which aids venous return, and that its action affects mainly the average of haemodynamic variables on the arterial side, while on the venous side it has a significant effect on wave periodicity and triggers a complex interplay in terms of waveform conformation. Additionally, we assess the sensitivity of model predictions to variations in model parameters through a local sensitivity analysis, both in the presence and absence of respiration, highlighting a strong relationship between the arterial and venous side of the model.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1653 - 1686"},"PeriodicalIF":2.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1653 - 1686"},"PeriodicalIF":2.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of demographics and risk factors on the nonlinear orthotropic mechanical properties of human femoropopliteal arteries","authors":"Majid Jadidi,&nbsp;Sayed Ahmadreza Razian,&nbsp;Alireza Zarreh,&nbsp;Ramin Shahbad,&nbsp;Alexey Kamenskiy","doi":"10.1007/s10237-025-01981-4","DOIUrl":"10.1007/s10237-025-01981-4","url":null,"abstract":"<div><p>Understanding how demographics and risk factors differentially affect the nonlinear orthotropic mechanical properties of human femoropopliteal arteries (FPAs) is critical for improving computational models of device–artery interactions. However, directly assessing these effects is challenging due to their intricate interrelationships and multifaceted impact on arterial mechanics. This study aimed to quantify the independent and combined effects of aging, diabetes, obesity, hypertension, and coronary artery disease on the mechanical behavior of human FPAs using machine learning (ML). FPAs from 450 tissue donors 12–99 years old (average age 51 ± 18 years, 66% male) were evaluated using multi-ratio planar biaxial extension. ML models, optimized through hyperparameter tuning and cross-validation, were used to describe subject-specific nonlinear orthotropic arterial properties based on demographics and risk factors. Age accounted for 60% of the variability in arterial mechanics and had a stronger influence longitudinally than circumferentially. The presence of diabetes and coronary artery disease each added 13 and 11 years to vascular age circumferentially but &lt; 3 years longitudinally. Obesity and hypertension each added 4 years to vascular age circumferentially and less than 3 years longitudinally. Compound effects of diabetes, hypertension, and obesity aged the artery more than 21 years circumferentially and 7 years longitudinally. These findings highlight the differential impact of risk factors on orthotropic arterial mechanics and demonstrate the potential of our approach for predicting subject-specific vascular properties. Incorporating these findings into computational models can enhance the accuracy of device–artery interaction simulations by accounting for individual-specific vascular characteristics.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1565 - 1589"},"PeriodicalIF":2.7,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-objective optimization of tracheal stent with J-shaped load–deformation behavior","authors":"Shiliang Chen,&nbsp;Tianming Du,&nbsp;Yuxuan Tao,&nbsp;Hanbing Zhang,&nbsp;Wei Wu,&nbsp;Yanping Zhang,&nbsp;Yunzhi Zhou,&nbsp;Yuan Cheng,&nbsp;Makoto Ohta,&nbsp;Aike Qiao","doi":"10.1007/s10237-025-01994-z","DOIUrl":"10.1007/s10237-025-01994-z","url":null,"abstract":"<div><p>The tracheal stent is one of the treatment modalities for tracheal stenosis. However, the mismatch of mechanical properties between the tracheal stent and the trachea may lead to stent migration. The aim of this study is to design a tracheal stent with J-shaped load–deformation behavior based on a multi-objective optimization method. Four design parameters were selected as optimization variables. The optimization objectives were the loads at 5%, 10%, 15%, and 20% deformation during uniaxial tensile test. The optimal Latin hypercube sampling was used to generate training samples, and Kriging surrogate model was constructed between tracheal stent design parameters and mechanical properties. An optimized stent model was established after obtaining the optimal stent design parameters by NSGA-II algorithm. Additionally, a commercial silicone stent model was established as the control. The results indicate that ligament angles and the width of circular arc connected ligaments play a prominent role in the load–deformation curve of the stent. The radial supporting performance (39.79 MPa vs. 4.63 MPa) and anti-migration properties (16.1 N vs. 13.7 N) of the optimized stent are superior to those of the silicone stent. This work demonstrates that a tracheal stent exhibiting a J-shaped load–deformation behavior was designed, which could reduce stent migration.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1797 - 1814"},"PeriodicalIF":2.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}