Role of player-specific white matter parcellation and scaling in impact-induced strain responses.

Abstract

Head finite element models (hFEMs) are valuable in understanding injury mechanisms in head impacts. Personalizing hFEMs is important for capturing individualized brain responses, with brain volume scaling proving effective. However, the role of refined white matter (WM) parcellation in hFEMs for evaluating brain strain responses, particularly important in the context of subconcussive head impacts (SHIs) often assessed through changes in WM integrity, remains relatively underexplored. This study evaluated the effect of refined subject-specific WM parcellation in 34 WM segments on responses variability due to brain volume variations, using peak maximum principal strain (95MPS) and strain rate (95MPSr) as injury predictive metrics. Data from diffusion-weighted imaging of 21 Canadian varsity football players were utilized to personalize 21 hFEMs. Simulating four different head impacts, representing 50th and 99th percentile resultant accelerations in frontal and angled-top-right directions, refined player-specific WM parcellation better captured variability of strain responses compared to baseline parcellation. Up to 75.71% of 95MPS and 77.14% of 95MPSr responses were deemed different across refined WM segments for players, compared to a maximum of 16.19% of responses with baseline parcellation. These results suggest that player-specific refined WM parcellation improves the ability to capture player-specific responses. Both impact direction and intensity influenced variations in strain response, with angled-top head impacts combined with high intensity showing greater player-specificity compared to lower intensity and frontal head impacts. These findings highlight the potential benefit of model scaling along with player-specific refined WM parcellation in hFEMs for comprehensively evaluating strain responses. Detailed WM parcellation in hFEMs is important for comprehensive injury assessment, enhancing the alignment of hFEMs with imaging studies evaluating changes in WM integrity across segments. The simple and straightforward method presented herein to achieve player-specific strain response is promising for future SHI studies.