Biomechanics and Modeling in Mechanobiology最新文献

{"title":"A comprehensive framework for computational modeling of growth and remodeling in tissue-engineered soft collagenous materials","authors":"M. Sesa,&nbsp;H. Holthusen,&nbsp;C. Böhm,&nbsp;S. Jockenhövel,&nbsp;S. Reese,&nbsp;K. Linka","doi":"10.1007/s10237-025-01988-x","DOIUrl":"10.1007/s10237-025-01988-x","url":null,"abstract":"<div><p>Developing clinically viable tissue-engineered structural cardiovascular implants—such as vascular grafts and heart valves—remains a formidable challenge. Achieving reliable and durable outcomes requires a deeper understanding of the fundamental mechanisms driving tissue evolution during in vitro maturation. Although considerable progress has been made in modeling soft tissue growth and remodeling, studies focused on the early stages of tissue engineering remain limited. Here, we present a general, thermodynamically consistent model to predict tissue evolution and mechanical response throughout the in vitro maturation of passive, load-bearing soft collagenous constructs. The formulation utilizes a stress-driven homeostatic surface to capture volumetric growth, coupled with an energy-based approach to describe collagen densification via the strain energy of the fibers. We further employ a co-rotated intermediate configuration to ensure the model’s consistency and generality. The framework is demonstrated with two numerical examples: a uniaxially constrained tissue strip validated against experimental data and a cruciform-shaped biaxially constrained specimen subjected to load perturbation. These results highlight the potential of the proposed model to advance the design and optimization of tissue-engineered structural cardiovascular implants with clinically relevant performance.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1687 - 1711"},"PeriodicalIF":2.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01988-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data-informed reconstruction of a bipennate muscle’s aponeurosis and its fibre distribution for performing continuum-mechanical simulations","authors":"A. Ranjan,&nbsp;O. Avci,&nbsp;O. Röhrle","doi":"10.1007/s10237-025-01989-w","DOIUrl":"10.1007/s10237-025-01989-w","url":null,"abstract":"<div><p>Alternatives to Diffusion-Tensor-Imaging tractography methods for determining fibre orientation fields in skeletal muscle include Laplacian flow simulations. Such methods require flux boundary conditions (BCs) at the tendons and/or along the inner aponeuroses, which can significantly influence the gradients of the resulting Laplacian flow. Herein, we propose a novel method based on solving the 3D steady-state thermal heat equations to determine the fibre architecture in a bi-pennate muscle, specifically the <i>m. rectus femoris</i>. Additionally, we propose a semi-automated algorithm that provides the geometrical representation of the anterior aponeurosis, which, along with the thermal-based fibre field, is particularly well suited for Finite Element (FE) simulations. The semi-automated reconstruction of the aponeurosis shows a good correlation with manual segmentation, yielding a dice coefficient (DSC) of 0.83. The metamodel-based approach resulted in fluxes with a mean angular deviation of <span>(14.25^circ ,pm ,10.36^circ)</span> and a fibre inclination from the muscle’s longitudinal axis of <span>(0.44^circ ,pm ,4.48^circ)</span>. Comparing the mechanical output of the same <i>m. rectus femoris</i> muscle geometry informed by the two respective fibre architectures showed that the most significant contributing factor was the relative fibre inclination. Compared to the standard deviation in the undeformed configuration (<span>(0.44^circ ,pm ,4.48^circ)</span>), the standard deviation of relative fibre inclination during passive stretching at low applied loads, for instance, at <span>(30%)</span> of the maximum applied load, showed a significant decrease (<span>(0.49^circ ,pm ,2.24^circ)</span>). Similarly, at maximum isometric contraction, the relative fibre inclinations at <span>(10%)</span> initial fibre pre-stretch are <span>(0.19^circ ,pm ,1.23^circ)</span>, indicating a drop in standard deviation from the undeformed configuration (<span>(0.44^circ ,pm ,4.48^circ)</span>). The current study demonstrates that despite the initial deviations in fibre orientations and relative fibre inclinations, thermal flux-based fibre orientations not only exhibit comparable results to DTI-based fibre tractography for the macroscopic analysis of the <i>m. rectus femoris</i> but also result in homogeneous stretch fields and improved numerical convergence. The proposed methods may be applied to determine inner aponeuroses of other bi- or multi-pennate muscles, enabling efficient in-silico computations of the musculoskeletal system.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1713 - 1734"},"PeriodicalIF":2.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01989-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ascending aortic aneurysm growth in the Fbln4SMKO mouse is consistent with uniform growth laws","authors":"Marisa S. Bazzi,&nbsp;Hadi Wiputra,&nbsp;Weihua Guan,&nbsp;Victor H. Barocas","doi":"10.1007/s10237-025-01972-5","DOIUrl":"10.1007/s10237-025-01972-5","url":null,"abstract":"<div><p>Arterial growth and remodeling (G&amp;R), in response to biomechanical stimuli, plays a pivotal role in vascular health. Disruptions in G&amp;R, often seen in conditions such as aneurysms and atherosclerosis, can lead to pathological changes and pose significant health risks. Assessing risk should not only consider the current state of the aneurysm but also how it develops over the subsequent months. Herein, we make a controlled, subject-specific assessment of maladaptive aortic tissue growth using data previously obtained for the <i>Fbln4</i>^<i>SMKO</i> mouse model. The computational model uses a locally applied continuum G&amp;R approach coupled with fluid–structure interaction (FSI) simulations. Ten mice were studied, exhibiting varying degrees of aneurysm formation over time. This investigation focused on the ascending aorta, where aneurysms develop in the <i>Fbln4</i>^<i>SMKO</i> mouse. A continuous G&amp;R model was tuned and evaluated using information from 2, 4, and 6 months obtained from CT scans. A G&amp;R model with uniform growth laws showed variable accuracy in predicting circumferential growth across different mice, exhibiting both under- and over-estimations compared to in vivo measurements. Modeling prediction showed to be improved by multiple-domain modeling. There is correlation between (1) the fitted circumferential growth time constants and the observed ascending aorta Young’s modulus and (2) the fitted axial growth time constant and the tortuosity index. Furthermore, the ratio of the circumferential growth time constant to the circumferential stress correlated with mouse lifespan more strongly than diameter change, suggesting that analysis of a G&amp;R model may be valuable in predicting risk of aneurysm rupture.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1485 - 1499"},"PeriodicalIF":2.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01972-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tension-area relationship in compartmentalized crumpled plasma membrane: a mechanistic model and its implications","authors":"Andrey K. Tsaturyan","doi":"10.1007/s10237-025-01992-1","DOIUrl":"10.1007/s10237-025-01992-1","url":null,"abstract":"<div><p>The plasma membrane is a liquid lipid bilayer containing both dissolved proteins and proteins anchoring the membrane to the underlying actin cortex. Membrane tension, a 2D analog of pressure in a 3D liquid, is believed to play a crucial role in organizing essential processes within cells and tissues. This, along with recent, conflicting data on the speed of membrane tension propagation, highlights the need for a comprehensive mechanical model to describe tension in the cortex-anchored plasma membrane as a function of transmembrane hydrostatic pressure difference and excess membrane area due to cortex contraction. In this study, we present a mechanical model of plasma membrane compartments, separated by \"picket fences\" of cortex-anchoring proteins permeable to lipids. Beyond hydrostatic pressure, the model incorporates the 2D osmotic pressure exerted by membrane-dissolved proteins. Our findings reveal that the tension-area relationship within a membrane compartment exhibits a seemingly paradoxical feature: in a specific range of membrane surface area, an increase in area leads to a rise in tension. We further model the tension-area relationship for an ensemble of membrane compartments, which exchange membrane area through shared borders, and discuss potential biological implications of this model.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1781 - 1795"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1781 - 1795"},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a subject-specific integrated finite element musculoskeletal model of human trunk with ergonomic and clinical applications","authors":"Farshid Ghezelbash,&nbsp;Amir Hossein Eskandari,&nbsp;Amir Jafari Bidhendi,&nbsp;Aboulfazl Shirazi-Adl,&nbsp;Christian Larivière","doi":"10.1007/s10237-025-01983-2","DOIUrl":"10.1007/s10237-025-01983-2","url":null,"abstract":"<div><p>Biomechanical modeling of the human trunk is crucial for understanding spinal mechanics and its role in ergonomics and clinical interventions. Traditional models have been limited by only considering the passive structures of the spine in finite element (FE) models or incorporating active muscular components in multi-body musculoskeletal (MS) models with an oversimplified spine. To address those limitations, we developed a subject-specific coupled FE-MS model of the trunk and explored its applications in ergonomics and surgical interventions. A parametric detailed FE model was constructed, integrated with a muscle architecture, and individualized based on existing datasets. Our comprehensive validation encompassed tissue-level responses, segment-level mechanics, and whole-spine behavior across multiple subjects and loading conditions, demonstrating satisfactory performance in ergonomics (i.e., wearing exoskeleton) and clinical interventions (nucleotomy and spinal fusion). The model accurately predicted tissue-level stresses (in uni- and biaxial loading), whole-spine motion (i.e., moment rotation response was in agreement with in vitro measurements), intradiscal pressures (RMSE = 0.12 MPa; <i>R</i>² = 0.72), and muscle activities (matching EMG trends across 19 subjects during forward flexion). Wearing an exoskeleton reduced intradiscal pressures (1.9 vs. 2.2 MPa at L4–L5) and peak von Mises stresses in the annulus fibrosus (2.2 vs. 2.9 MPa) during forward flexion. Spinal fusion (at L4–L5) increased the intradiscal pressure in the upper adjacent disc (1.72 MPa vs. 1.58 MPa), but nucleotomy had a minimal effect on the intact intradiscal pressures. Nucleotomy substantially affected the load transfer at the same level by increasing facet contact loads and annulus radial strains. Unlike conventional MS models with simplified spine, and in contrast to passive models (without active components), this model provides crucial outputs such as strain/stress fields in discs/facets (essential for a comprehensive risk analysis). This integrated approach enables more accurate surgical planning, workplace safety design, and personalized rehabilitation strategies, helping reduce spine-related injuries by identifying risk factors and optimizing interventions for individual patients.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1591 - 1603"},"PeriodicalIF":2.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing cardiac biomechanical models beyond the clinic: modeling stressors of daily life","authors":"Alexandre Lewalle,&nbsp;Tiffany M. G. Baptiste,&nbsp;Rosie K. Barrows,&nbsp;Ludovica Cicci,&nbsp;Cesare Corrado,&nbsp;Angela W. C. Lee,&nbsp;Cristobal Rodero,&nbsp;José Alonso Solís-Lemus,&nbsp;Marina Strocchi,&nbsp;Steven A. Niederer","doi":"10.1007/s10237-025-01982-3","DOIUrl":"10.1007/s10237-025-01982-3","url":null,"abstract":"<div><p>There is growing motivation to exploit computational biomechanical modeling of the heart as a predictive tool to support clinical diagnoses and therapies. Existing patient-specific cardiac models often rely on data collected under highly standardized conditions in hospitals. However, disease progression and therapy responses often depend on stressors, encountered in daily life, that cannot be captured in a traditional clinical setting. To achieve clinical translation, existing modeling frameworks must be refined and extended to include such influences. The “digital twin” concept, in which models of specific systems are continually updated with new data, is a promising avenue for integrating and interpreting these data streams. However, this endeavor calls for novel approaches to model development and data acquisition and integration. We review modeling approaches addressing specific stressor types (caffeine, exercise, sex-dependent factors, sleep, the environment) to identify knowledge gaps, assess emerging technical challenges, and suggest potential model developments to extend the scope and reach of biomedical cardiac simulations.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1447 - 1464"},"PeriodicalIF":2.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01982-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of lattice structures for trabecular-bone scaffolds: comparative analysis of morphology and compressive mechanical behaviour","authors":"Yulia Pirogova,&nbsp;Mikhail Tashkinov,&nbsp;Ilia Vindokurov,&nbsp;Nataliya Elenskaya,&nbsp;Anastasia Tarasova,&nbsp;Aleksandr Shalimov,&nbsp;Vadim V. Silberschmidt","doi":"10.1007/s10237-025-01980-5","DOIUrl":"10.1007/s10237-025-01980-5","url":null,"abstract":"<div><p>The study is focused on comparative analysis of different concepts for design of scaffolds for bone tissue engineering based on investigation of their local physical–mechanical properties and response to compression load. Three-dimensional additively manufactured lattice scaffolds with various morphological characteristics and mechanical responses are investigated numerically and experimentally and compared to representative volume elements of real random microstructure of trabecular bone. Prototypes of the studied structures are fabricated with polylactide using a fused filament fabrication technique. Numerical analysis of stress–strain state of scaffolds under compressive loading is performed. The effect of changes in structural morphology parameters on the initiation of stress concentrators as well as nucleation and propagation of fracture is studied. Strain fields on samples’ surfaces, captured in the experiments with a micro-digital image correlation technique, are in good agreement with the obtained numerical results. Comparison of the mechanical behaviour and properties of the lattice-scaffold prototypes with those of trabecular bone allows conclusions about selection of their rational morphological structure. Based on the results obtained with the comprehensive analysis, two promising approaches to create scaffolds similar to trabecular bone were identified: models based on a variation of the gyroid surface and ones using Voronoi tessellation with Lloyd's relaxation algorithm.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1535 - 1564"},"PeriodicalIF":2.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 2D computational model of chemically- and mechanically-induced platelet plug formation","authors":"Giulia Cardillo,&nbsp;Abdul I. Barakat","doi":"10.1007/s10237-025-01966-3","DOIUrl":"10.1007/s10237-025-01966-3","url":null,"abstract":"<div><p>Thrombotic deposition plays a critical role in the evolution of various vascular pathologies and is a major consideration in the development of cardiovascular devices. Although experimental evidence has shown that shear gradients in blood flow play a critical role in thrombogenesis, the impact of these gradients has not been included in previous computational models of thrombosis. The goal of the present work is to develop a predictive computational model of platelet plug formation that accounts for the role of shear gradients. A 2D computational model of platelet-mediated thrombogenesis was developed using the commercial finite element solver COMSOL Multiphysics 5.6. The model includes platelet transport, activation, adhesion and aggregation induced by both biochemical and mechanical factors. Platelet and agonist transport are described by a coupled set of convection-diffusion–reaction equations. Platelet adhesion and aggregation at the vascular surface are modeled via flux boundary conditions. Thrombus growth and its impact on blood flow are modeled using a moving surface mesh. The model provides the spatiotemporal evolution of a platelet plug in the flow field. After validation against experimental data in the literature, the model was used to predict the location and growth dynamics of platelet plugs in various vascular geometries. The results confirm the importance of considering both mechanical and chemical platelet aggregation and underscore the essential role that shear gradients play in platelet plug formation. The developed model represents a potentially useful tool for thrombogenesis prediction in pathological scenarios and for the optimization of endovascular device design.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1465 - 1484"},"PeriodicalIF":2.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01966-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical study of nasal hair effects on breathing comfort and particle deposition in a simplified vestibule region","authors":"Hasan Fatahi,&nbsp;Alireza Dastan,&nbsp;Sasan Sadrizadeh,&nbsp;Omid Abouali","doi":"10.1007/s10237-025-01979-y","DOIUrl":"10.1007/s10237-025-01979-y","url":null,"abstract":"<div><p>Nasal hairs, often overlooked in human respiratory system studies, can be a decisive factor in maintaining respiratory health. Vibrissae can capture a certain range of particle sizes due to their filtering function, while they may also contribute to more breathing resistance. In this study, the role of nasal hairs in particle filtration and pressure drop within the nasal vestibule was investigated using computational fluid dynamics (CFD) simulations. Seven nasal hair specifications were examined in simplified human nasal vestibule models under steady laminar flow conditions at two airflow rates of 10 and 15 L/min. The deposition of microparticles in the simulated geometries was also numerically studied. The simulation results showed that the investigated nasal hairs lead to about a 2–20 Pa increase in the pressure drop, depending on the hair specifications and airflow rates. The associated growth in nasal resistance could potentially influence breathing comfort. Additionally, nasal hair was shown to enhance particle filtration, with the deposition fraction of particles correlating with the projected area of the hairs on a normal plane to the flow direction, which goes up by an increase in the number of hairs or their length. These findings clarify the significance of nasal hairs in the respiratory system and aim to balance the trade-off between improved particle filtration and increased breathing resistance due to nasal hairs. The acquired knowledge can be used in recommendations to different individuals regarding nasal hair trimming based on their health conditions.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1513 - 1533"},"PeriodicalIF":2.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}