Biomechanics and Modeling in Mechanobiology最新文献

{"title":"Orthogonal alignment of multilayered MC3T3-E1 cells induced by cyclic stretch","authors":"Shuichiro Suzuki,&nbsp;Ken Imajo,&nbsp;Junfeng Wang,&nbsp;Jeonghyun Kim,&nbsp;Eijiro Maeda,&nbsp;Kazuaki Nagayama,&nbsp;Takeo Matsumoto","doi":"10.1007/s10237-025-01978-z","DOIUrl":"10.1007/s10237-025-01978-z","url":null,"abstract":"<div><p>When cyclic stretch is applied to a monolayer of cells cultured on an elastic substrate, many types of cells align in the direction perpendicular to the stretch or along the direction of minimal substrate strain. However, the behavior of multilayer cells under cyclic stretch remains unclear. In this study, we cultured MC3T3-E1 osteoblast-like cells at high density to form multilayer cells and subjected them to cyclic stretch with an amplitude of 10% at 1 Hz. We found that the lower layer cells aligned in the direction of the stretch after 12 h, whereas the upper layer cells aligned perpendicular to the direction of stretch after 24 h. The 10% cyclic stretch was transmitted to the upper layer cells as approximately 5% at the onset of the stretch and increased over time, reaching 7% at 12 h when the lower layer cells completed alignment in the direction of stretch. This suggests that sufficient cyclic stretch transmitted to the upper layer led to the alignment of the upper layer cells in the perpendicular direction after 12 h. On the other hand, reducing intracellular tension with Y-27632 caused cells in both upper and lower layers to align in the direction of stretch. In contrast, increasing intracellular tension with calyculin A eliminated significant alignment in both layers. These findings indicate that cell alignment is closely related to intracellular tension and that the alignment of the lower layer cells in the direction of stretch may be due to a decrease in intracellular tension.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 5","pages":"1501 - 1511"},"PeriodicalIF":2.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01978-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing airflow ventilation in a nasal maxillary ostium using optimised shape and pulsating flows","authors":"Patrick Warfield-McAlpine,&nbsp;David F. Fletcher,&nbsp;Fiona Zhang,&nbsp;Kiao Inthavong","doi":"10.1007/s10237-025-01971-6","DOIUrl":"10.1007/s10237-025-01971-6","url":null,"abstract":"<div><p>Ventilation of the maxillary sinus is essential for regulating pressure, preventing infection and providing mucous to the nasal anatomy. During infection, the pathway between the sinus and the nasal airway (ostia) can become inflamed and restrict ventilation. Surgery is often required to restore airflow. The current surgical standard involves the widening of the ostium. Although this restores fluid flow, it has been linked to post-surgical sequelae. This study examined the effects of pulsating flow and geometric modifications on airflow distribution in a T-junction model analogous to a nasal maxillary ostium. A circular T-junction with variable anterior and posterior radius of curvature (<span>(R_c)</span>) was used to simulate airflow through the nasal maxillary ostium, investigating flow behaviour under oscillatory inlet velocities at frequencies of 30, 45, 60, and 75 Hz. Computational fluid dynamics (CFD) simulations assessed how flow distribution through the nasal cavity and maxillary ostium (represented by the <i>x</i>- and <i>y</i>-branches) is affected by curvature and oscillatory frequency, focusing on implications for respiratory airflow, particle delivery and inhalation toxicology. Results indicated that increasing the anterior <span>(R_c)</span> enhanced airflow into the <i>y</i>-branch (analogous to the maxillary ostium), while posterior curvature had minimal impact. Higher oscillatory frequencies increased reverse flow, which may improve ventilation but could interfere with consistent drug delivery. These insights are valuable for optimising respiratory therapies and inhalation toxicology.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1343 - 1362"},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational modeling of vacuum-assisted delivery: biomechanics of maternal soft tissues","authors":"Rita Moura,&nbsp;Dulce A. Oliveira,&nbsp;Nina Kimmich,&nbsp;Renato M. Natal Jorge,&nbsp;Marco P. L. Parente","doi":"10.1007/s10237-025-01977-0","DOIUrl":"10.1007/s10237-025-01977-0","url":null,"abstract":"<div><p>Childbirth is a complex process influenced by physiological, mechanical, and hormonal factors. While natural vaginal delivery is the safest, it is not always feasible due to diverse circumstances. In such cases, assisted delivery techniques, such as vacuum-assisted delivery (VAD), may facilitate vaginal birth. However, this technique can be associated with a higher risk of maternal injuries, potentially resulting in long-term conditions such as pelvic organ prolapse or incontinence. This study investigates the biomechanical impact of VAD on maternal tissues, aiming to reduce these risks. A finite element model was developed to simulate VAD, incorporating maternal musculature, a deformable fetal head, and a vacuum cup. Twelve simulations were conducted, varying contraction durations, resting intervals, and the number of pulls required for fetal extraction. Results revealed that prolonged contraction durations, coupled with extended resting intervals, lead to a reduction in pelvic floor stress. Elevated stress levels were observed when fetal extraction involved two pulls, with an 8.43% decrease in maximum stress from two pulls to four. The peak stress recorded was 0.81 MPa during a 60-second contraction, followed by a 60-second rest period. These findings indicate that longer maneuvers may reduce trauma, as extended pulls allow muscles more time to relax and recover during both contraction and rest phases. Furthermore, an increased number of pulls extends the duration of the maneuver, facilitating fetal rotation and improved adjustment to the birth canal. This study offers crucial insights into the biomechanics of childbirth, providing clinicians with valuable information to enhance maternal outcomes and refine assisted delivery techniques.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1435 - 1446"},"PeriodicalIF":2.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propagating instabilities in long collapsible tubes of nonlinear biological material","authors":"Aris G. Stamou,&nbsp;Ilias Gavriilidis,&nbsp;Ioanna D. Karetsa,&nbsp;Spyros A. Karamanos","doi":"10.1007/s10237-025-01973-4","DOIUrl":"10.1007/s10237-025-01973-4","url":null,"abstract":"<div><p>Proper functionality of human body relies on several continuous physical processes, many of which are carried out through biological ducts/tubes. For instance, veins, arteries and airways into the human body are natural conduit systems where blood and air are conveyed. Those elastic tubular components are prone to structural instability (buckling) and eventually collapse under critical conditions of net external pressure, resulting in malfunctioning of main physical processes. In the present work, collapsible elastic tubes are studied from a structural mechanics perspective, examining their resistance to collapse under uniform external pressure, emphasizing on the influence of nonlinear material behavior. The problem is approached numerically using nonlinear finite element models, to analyze tubes with diameter-to-thickness ratio ranging from 9 to 30, considering different nonlinear elastic material properties and focusing on the post-buckling phenomenon of “buckling propagation”. It is demonstrated that small softening deviations from linear elastic behavior may cause a localized collapse pattern followed by its propagation along the tube with a pressure lower than the collapse pressure. Results from two-dimensional (ring) and more rigorous three-dimensional (3<i>D</i>) finite element models are obtained in terms of the collapse pressure value and the propagation pressure value, i.e., the minimum pressure required for a localized buckling pattern to propagate, and the two models provide very similar predictions. A simple analytical model is also employed to explain the phenomenon of collapse localization and its subsequent propagation. In addition, special emphasis is given on the correlation between the 3<i>D</i> results and those from ring analysis in terms of the propagation profile and the energy required for the collapse pattern to advance. Finally, comparison with numerical results from tubes made of elastic–plastic material is performed to elucidate some special features of the propagation phenomenon.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1363 - 1384"},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covariation between rotator cuff muscle quality and shoulder morphometric bony features in B-glenoids: a statistical modeling approach","authors":"Nazanin Daneshvarhashjin,&nbsp;Philippe Debeer,&nbsp;Harold Matthews,&nbsp;Peter Claes,&nbsp;Filip Verhaegen,&nbsp;Lennart Scheys","doi":"10.1007/s10237-025-01947-6","DOIUrl":"10.1007/s10237-025-01947-6","url":null,"abstract":"<div><p>Rotator cuff muscle (RCM) degeneration, bone morphology, and humeral head subluxation (HHS) are known risk factors for failure of anatomic total shoulder arthroplasty in patients with B-glenoid shoulder osteoarthritis. Yet, the understanding of RCM asymmetry in these patients remains an area of active investigation, including its relation with other risk factors. We therefore aimed to characterize the variability of RCM degeneration in B-glenoids and analyze its covariation with scapular morphology and HHS. First, computed tomography images were used to quantify 3D RCM degeneration, including muscle atrophy and fatty infiltration, in sixty B-glenoids referenced against twenty-five healthy controls. Next, the 3D scapular shape of B-glenoids was quantified using a previously published statistical shape model. Thirdly, 3D HHS was quantified. Using dedicated correlation analyses covariation patterns were modeled between each of these risk factors. Results indicated that RCM degeneration in B-glenoids is primarily characterized by fatty infiltration, without any sign of asymmetric impact on the anterior versus posterior RCM. However, B-glenoids with asymmetric bone loss were found to have more RCM atrophy and fatty infiltration of the infraspinatus. We identified four significant patterns of RCM degeneration and scapular shape, explaining 90.3% of their correlation. The primary mode indicates an association between combined posterior glenoid erosion and coracoid rotation with an increased infraspinatus’ fatty infiltration. Interestingly, this mode was also positively correlated with posterior HHS (<i>r</i> = 0.46, <i>P</i> &lt; 0.01). Identification of such patterns can improve the accuracy of musculoskeletal models in predicting postoperative implant failure risks.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1141 - 1153"},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical study of the structural design influence on cartilage cell differentiation in mechanically stimulated hydrogel scaffolds using an FSI-based model","authors":"Pedram Azizi,&nbsp;Christoph Drobek,&nbsp;Hermann Seitz","doi":"10.1007/s10237-025-01976-1","DOIUrl":"10.1007/s10237-025-01976-1","url":null,"abstract":"<div><p>Three-dimensional (3D) hydrogel scaffolds show considerable promise for the regenerative treatment of cartilage and bone defects. Within tissue engineering, these scaffolds can be mechanically stimulated to specifically promote cartilage formation. While in vitro experiments are traditionally used to study the influence of scaffold structure on cell differentiation, in silico studies offer a complementary, cost-effective, and powerful approach. This numerical study employs a transient fluid–structure interaction (FSI) model to modify the structural design of a mechanically stimulated hydrogel scaffold for enhanced cartilage cell differentiation. The study involved two key modification steps applied to scaffolds under 5% compression. In the first step, scaffold porosity was adjusted by altering the number of strands per layer. The scaffold designed with 38% porosity, consisting of 9 strands per layer across 9 layers, improved cartilage differentiation by approximately 15%. The second step focused on scaling the selected scaffold from step 1 by adjusting the number of layers while keeping the porosity constant, aiming to optimize pore dimensions. This led to a slight improvement in cartilage differentiation of about 2.3%. The results indicate that porosity exerts a more significant influence on cell differentiation than pore size in the structured scaffolds investigated. The FSI-based model demonstrates strong potential for analyzing the impact of pore architecture on cell differentiation, although manufacturing challenges of hydrogel scaffolds may limit the practical application of these modification strategies.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1417 - 1433"},"PeriodicalIF":2.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of coronary outflow and non-Newtonian fluid property on aortic valve haemodynamics","authors":"Zhongjie Yin,&nbsp;Chlöe Armour,&nbsp;Harkamaljot Kandail,&nbsp;Declan P. O’Regan,&nbsp;Toufan Bahrami,&nbsp;Saeed Mirsadraee,&nbsp;Selene Pirola,&nbsp;Xiao Yun Xu","doi":"10.1007/s10237-025-01975-2","DOIUrl":"10.1007/s10237-025-01975-2","url":null,"abstract":"<div><p>The normal healthy aortic valve (AoV) has three leaflets, two of which have outflows to the coronary arteries. Blood flow through the coronary ostia will have an impact on AoV dynamics and the surrounding haemodynamics, leading to differential shear stress distributions at the aortic side of the three leaflets. In addition, aortic root haemodynamics may also be influenced by the non-Newtonian behaviour of blood which is known as a shear-thinning fluid due to the aggregation of red blood cells at low shear rate. However, the combined effect of coronary and non-Newtonian flow on AoV haemodynamics has not been studied in an anatomically realistic setting. In this study, strongly coupled fluid–structure interaction (FSI) analyses were performed on a natural, healthy AoV, with and without accounting for coronary outflows and non-Newtonian properties of blood. Our results showed that the influence of coronary outflow is more pronounced than employing a non-Newtonian model, and their combined effect is non-negligible, particularly on wall shear stress. Incorporating coronary outflow and non-Newtonian properties increased time-averaged wall shear stress (TAWSS) in the aortic sinus by up to 108.45%; it also increased TAWSS on the aortic side of valve leaflets by 41.04%, 44.76%, and 54.91% on the left, right and non-coronary leaflet, respectively. These results highlight the importance of incorporating coronary outflow and non-Newtonian properties when accurate predictions of wall shear stress and its related parameters are critical.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1401 - 1416"},"PeriodicalIF":2.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left coronary artery biomechanics: a characterization study using fluid structure interaction simulations","authors":"Marina Fandaros,&nbsp;Chloe Kwok,&nbsp;Zachary Wolf,&nbsp;Michael Shearer,&nbsp;Johnathan Scheiner,&nbsp;Yulee Li,&nbsp;J. Jane Cao,&nbsp;Wei Yin","doi":"10.1007/s10237-025-01974-3","DOIUrl":"10.1007/s10237-025-01974-3","url":null,"abstract":"<div><p>Patient-specific coronary artery biomechanics studies often have limited sample size. The goals of this study were: (1) To develop more patient-specific FSI models to expand current research effort in characterizing hemodynamic and biomechanical conditions within the coronary arteries; (2) to compare some of our model outputs, especially FSI model-generated vFFR values, to those provided by HeartFlow, to evaluate the clinical relevance of our model results. Ten healthy LCA geometries were used to develop patient-specific FSI models using COMSOL Multiphysics. The hemodynamic and biomechanical environment in the arterial wall were assessed, along the proximal, mid, and distal portions of the left anterior descending coronary artery (LAD). The FSI model-calculated vFFR was compared to the matched HeartFlow reports. All FSI models indicated healthy perfusion. There was a good agreement with the HeartFlow calculation in the proximal LAD. The FSI model results indicated that the wall stresses were below the rupture thresholds. However, variations were observed along the arterial length in the von-Mises stress and strains. The FSI models offered improved physiological relevance for LCA simulation by including a large field of view. The biomechanical parameters were minimally related to geometric features, necessitating this procedure. This FSI modeling approach presented a few limitations. More work is needed to address these limitations and improve the physiological relevance of FSI modeling, so it can serve as a non-invasive method to assess the biomechanics of the coronary arteries, to support clinician’s decision making.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1385 - 1400"},"PeriodicalIF":2.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image-based computational hemodynamics in the right heart","authors":"Francesca Renzi,&nbsp;Giovanni Puppini,&nbsp;Giovanni B. Luciani,&nbsp;Christian Vergara","doi":"10.1007/s10237-025-01963-6","DOIUrl":"10.1007/s10237-025-01963-6","url":null,"abstract":"<div><p>Characterizing flow within the right heart (RH) is particularly challenging due to its complex geometries. However, gaining insight into RH fluid dynamics is of extreme diagnostic importance, given the high prevalence of acquired and congenital heart diseases with impaired RH function. In this proof-of-concept study, we propose a pipeline for patient-specific simulations of RH hemodynamics. We reconstruct the geometry and motion of the patient’s right atrium, ventricle, and pulmonary and tricuspid valves, from multi-series cine MRI. For this purpose, we develop a novel and flexible reconstruction procedure that, for the first time, integrates patient-specific tricuspid valve dynamics into a computational model, enhancing the accuracy of our RH blood flow simulations. We apply this approach to study the hemodynamics in both healthy and repaired-ToF RH with severe pulmonary regurgitation, as well as to assess the hemodynamic changes induced by the pulmonary valve replacement intervention. Modeling the entire RH enables us to understand the contribution of the superior and inferior vena cava inflows to the ventricular filling, as well as the impact of the impaired right atrial function on the ventricular diastole. To analyze the turbulent and transitional behavior, we include the large eddy simulation sigma model in our computational framework, which reveals how the contribution of the smallest scales in the dissipation of the turbulent energy changes among health and disease.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1223 - 1250"},"PeriodicalIF":2.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic differences and endoleak risk assessment of different angles of chimney stent graft deployment in chimney technique using integrated structural and fluid dynamics simulation","authors":"Xiao Han,&nbsp;Jing Zhu,&nbsp;Yue Che,&nbsp;Xiran Cao,&nbsp;Mingyu Wan,&nbsp;Xinhui Si,&nbsp;Wei Wang,&nbsp;Chang Shu,&nbsp;Mingyao Luo,&nbsp;Xuelan Zhang","doi":"10.1007/s10237-025-01964-5","DOIUrl":"10.1007/s10237-025-01964-5","url":null,"abstract":"<div><p>Chimney technique is an effective method for guaranteeing left subclavian artery (LSA) revascularization for patients receiving thoracic endovascular aortic repair. However, the complications like endoleak often occur after the chimney technique, and clinical studies have shown that they are closely related to the configuration of the chimney stent graft (SG). In this paper, we simulated the deployment of chimney SG with different angles and thoracic aortic SG, and analyzed the risk of complications according to numerical simulation results. Thoracic aortic SG and chimney SGs with different angles were designed based on patient-specific aortic geometry. The dynamic deployment process of SGs was simulated, followed by computational fluid dynamics (CFD) analysis to evaluate hemodynamic differences. Results indicate that the angle of chimney SG has little influence on the von Mises stress on the vascular wall. The endoleak flow rate at peak systole reached 11.15 ml/s in the 70° configuration, which is 1.80 times that of the 45° configuration. Meanwhile, the flow rate of LSA reached 5.94 ml/s in the 45° configuration, which is 1.21 times that of the 70° configuration. This indicates that the 45° configuration may reduce the risk of endoleak and flow obstruction to LSA. In addition, the relative residence time of 0° or 15° configuration is larger, suggesting a higher risk of thrombosis. This study employs virtual stent deployment and CFD analysis to predict the risk of complications associated with the deployment of chimney stents with different angles, potentially aiding surgeons in selecting the most appropriate surgical plan.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1251 - 1266"},"PeriodicalIF":2.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}