Biomechanics and Modeling in Mechanobiology最新文献_第6页

Cellular solids and prestressed affine networks as models of the elastic behavior of soft biological structures 作为软生物结构弹性行为模型的细胞固体和预应力仿射网络。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-10-15 DOI: 10.1007/s10237-024-01894-8

Dimitrije Stamenović

{"title":"Cellular solids and prestressed affine networks as models of the elastic behavior of soft biological structures","authors":"Dimitrije Stamenović","doi":"10.1007/s10237-024-01894-8","DOIUrl":"10.1007/s10237-024-01894-8","url":null,"abstract":"<div><p>We reviewed two microstructural models, cellular solid models and prestressed affine network models, that have been used previously in studies of elastic behavior of soft biological materials. These models provide simple and mathematically transparent equations that can be used to interpret experimental data and to obtain quantitative predictions of the elastic properties of biological structures. In both models, volumetric density and elastic properties of the microstructure are key determinants of the macroscopic elastic properties. In the prestressed network model, geometrical rearrangement of the microstructure (kinematic stiffness) is also important. As examples of application of these models, we considered the shear behavior of the cytoskeleton of adherent cells, of the collagen network of articular cartilage, and of the lung parenchymal network since their ability to resist shear is important for their normal biological and physiological functions. All three networks carry a pre-existing stress (prestress). We predicted their shear moduli using the microstructural models and compared those predictions with existing experimental data. Prestressed network models of the cytoskeleton and of the lung parenchyma provided a better correspondence to experimental data than cellular solid models. Both cellular solid and prestressed network models of the cartilage collagen network provided reasonable agreements with experimental values. These findings suggested that the kinematic stiffness and material stiffness of microstructural elements were both important determinants of the shear modulus of the cytoskeleton and of the lung parenchyma, whereas elasticity of collagen fibrils had a predominant role in the cartilage shear behavior.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 1","pages":"1 - 15"},"PeriodicalIF":3.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a framework for predicting immunotherapy outcome: a hybrid multiscale mathematical model of immune response to vascular tumor growth 建立免疫疗法结果预测框架：血管肿瘤生长免疫反应的混合多尺度数学模型。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-10-07 DOI: 10.1007/s10237-024-01891-x

Sayyed Mohammad Ali Mortazavi, Bahar Firoozabadi

{"title":"Towards a framework for predicting immunotherapy outcome: a hybrid multiscale mathematical model of immune response to vascular tumor growth","authors":"Sayyed Mohammad Ali Mortazavi, Bahar Firoozabadi","doi":"10.1007/s10237-024-01891-x","DOIUrl":"10.1007/s10237-024-01891-x","url":null,"abstract":"<div><p>Studying tumor immune microenvironment (TIME) is pivotal to understand the mechanism and predict the outcome of cancer immunotherapy. Systems biology mathematical models can consider and control various factors of TIME and therefore explore the anti-tumor immune response meticulously. However, the role of tumor vasculature in the recruitment of T cells and the mechanism of T cell migration through TIME have not been studied comprehensively. In this work, we developed a hybrid discrete-continuum multi-scale model to study TIME. The mathematical model includes angiogenesis and T cell recruitment via tumor vasculature. Moreover, solid tumor growth, vascular growth and remodeling, interstitial fluid flow, hemodynamics, and blood rheology are all considered in the model. In addition, different aspects of T cells, including their migration, proliferation, subtype conversion, and interaction with tumor cells are thoroughly included. The model reproduces spatiotemporal distribution of tumor infiltrating T cells that mimics histopathological patterns. Furthermore, TIME model robustly recapitulates different phases of tumor immunoediting. We also examined a number of biomarkers to predict the outcome of immune checkpoint blockade (ICB) treatment. The results demonstrated that although tumor mutational burden (TMB) may predict non-responders to ICB, a combination of different biomarkers is essential to predict the majority of the responders. Based on our results, the ICB response rate varies significantly from 28 to 89% depending on the values of different parameters, even in the cases with high TMB.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"23 6","pages":"2243 - 2264"},"PeriodicalIF":3.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of a self-expandable stent with the arterial wall in the presence of hypocellular and calcified plaques 存在低细胞和钙化斑块时自膨胀支架与动脉壁的相互作用。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-10-06 DOI: 10.1007/s10237-024-01896-6

Zubeir Allum Saib, Farid Abed, Mergen H. Ghayesh, Marco Amabili

{"title":"Interaction of a self-expandable stent with the arterial wall in the presence of hypocellular and calcified plaques","authors":"Zubeir Allum Saib, Farid Abed, Mergen H. Ghayesh, Marco Amabili","doi":"10.1007/s10237-024-01896-6","DOIUrl":"10.1007/s10237-024-01896-6","url":null,"abstract":"<div><p>Self-expandable stents manufactured from nitinol alloys are commonly utilized alongside traditional balloon-expandable stents to provide scaffolding to stenosed arteries. However, a significant limitation hampering stent efficacy is restenosis, triggered by neointimal hyperplasia and resulting in the loss of gain in lumen size, post-intervention. In this study, a nonlinear finite element model was developed to simulate stent crimping and expansion and its interaction with the surrounding vessel in the presence of a plaque. The main aim was to determine contact pressures and forces induced at the interface between an artery wall with hypocellular and calcified plaques and an expanded stent. The results demonstrated the drawbacks of plaque calcification, which triggered a sharp contact pressure and radial force surge at the interface as well as a significant rise in von Mises stress within the vessel, potentially leading to rupture and restenosis. A regression line was then established to relate hypocellular and calcified plaques. The adjusted coefficient of determination indicated a good correlation between contact pressures for calcified and hypocellular plaque models. Regarding the directionality of wall properties, contact pressure and force observations were not significantly different between isotropic and anisotropic arteries. Moreover, variations in friction coefficients did not substantially affect the interfacial contact pressures.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 1","pages":"77 - 91"},"PeriodicalIF":3.0,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A model of mechanical loading of the lungs including gravity and a balancing heterogeneous pleural pressure 包括重力和平衡异质胸膜压力在内的肺部机械负荷模型。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-10-05 DOI: 10.1007/s10237-024-01876-w

Alice Peyraut, Martin Genet

{"title":"A model of mechanical loading of the lungs including gravity and a balancing heterogeneous pleural pressure","authors":"Alice Peyraut, Martin Genet","doi":"10.1007/s10237-024-01876-w","DOIUrl":"10.1007/s10237-024-01876-w","url":null,"abstract":"<div><p>Recent years have seen the development of multiple <i>in silico</i> lung models, notably with the aim of improving patient care for pulmonary diseases. These models vary in complexity and typically only consider the implementation of pleural pressure, a depression that keeps the lungs inflated. Gravity, often considered negligible compared to pleural pressure, has been largely overlooked, also due to the complexity of formulating physiological boundary conditions to counterbalance it. However, gravity is known to affect pulmonary functions, such as ventilation. In this study, we incorporated gravity into a recent lung poromechanical model. To do so, in addition to the gravitational body force, we proposed novel boundary conditions consisting in a heterogeneous pleural pressure field constrained to counterbalance gravity to reach global equilibrium of applied forces. We assessed the impact of gravity on the global and local behavior of the model, including the pressure–volume response and porosity field. Our findings reveal that gravity, despite being small, influences lung response. Specifically, the inclusion of gravity in our model led to the emergence of heterogeneities in deformation and stress distribution, compatible with <i>in vivo</i> imaging data. This could provide valuable insights for predicting the progression of certain pulmonary diseases by correlating areas subjected to higher deformation and stresses with disease evolution patterns.\u0000</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"23 6","pages":"1933 - 1962"},"PeriodicalIF":3.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling aortic hemodynamics using fluid structure interaction: biomechanical insights into bicuspid aortic valve dynamics with multiple aortic lesions 利用流体结构相互作用揭示主动脉血液动力学：从生物力学角度洞察多主动脉病变的双尖瓣主动脉瓣动力学。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-10-04 DOI: 10.1007/s10237-024-01892-w

Vijay Govindarajan, Charles Wanna, Nils P. Johnson, Arun V. Kolanjiyil, Hyunggun Kim, Danai Kitkungvan, David M. McPherson, Jane Grande-Allen, Krishnan B. Chandran, Antony Estrera, Danny Ramzy, Siddharth Prakash

{"title":"Unraveling aortic hemodynamics using fluid structure interaction: biomechanical insights into bicuspid aortic valve dynamics with multiple aortic lesions","authors":"Vijay Govindarajan, Charles Wanna, Nils P. Johnson, Arun V. Kolanjiyil, Hyunggun Kim, Danai Kitkungvan, David M. McPherson, Jane Grande-Allen, Krishnan B. Chandran, Antony Estrera, Danny Ramzy, Siddharth Prakash","doi":"10.1007/s10237-024-01892-w","DOIUrl":"10.1007/s10237-024-01892-w","url":null,"abstract":"<div><p>Aortic lesions, exemplified by bicuspid aortic valves (BAVs), can complicate congenital heart defects, particularly in Turner syndrome patients. The combination of BAV, dilated ascending aorta, and an elongated aortic arch presents complex hemodynamics, requiring detailed analysis for tailored treatment strategies. While current clinical decision-making relies on imaging modalities offering limited biomechanical insights, integrating high-performance computing and fluid–structure interaction algorithms with patient data enables comprehensive evaluation of diseased anatomy and planned intervention. In this study, a patient-specific workflow was utilized to biomechanically assess a Turner syndrome patient’s BAV, dilated ascending aorta, and elongated arch. Results showed significant improvements in valve function (effective orifice area, EOA increased approximately twofold) and reduction in valve stress (~ 1.8-fold) following virtual commissurotomy, leading to enhanced flow dynamics and decreased viscous dissipation (~ twofold) particularly in the ascending aorta. However, increased viscous dissipation in the distal transverse aortic arch offset its local reduction in the AAo post-intervention, emphasizing the elongated arch’s role in aortic hemodynamics. Our findings highlight the importance of comprehensive biomechanical evaluation and integrating patient-specific modeling with conventional imaging techniques for improved disease assessment, risk stratification, and treatment planning, ultimately enhancing patient outcomes.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 1","pages":"17 - 27"},"PeriodicalIF":3.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing post-TAVR cardiac conduction abnormalities risk using an electromechanically coupled beating heart 使用机电耦合跳动心脏评估 TAVR 术后心脏传导异常风险。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-10-03 DOI: 10.1007/s10237-024-01893-9

Symon Reza, Brandon Kovarovic, Danny Bluestein

{"title":"Assessing post-TAVR cardiac conduction abnormalities risk using an electromechanically coupled beating heart","authors":"Symon Reza, Brandon Kovarovic, Danny Bluestein","doi":"10.1007/s10237-024-01893-9","DOIUrl":"10.1007/s10237-024-01893-9","url":null,"abstract":"<div><p>Transcatheter aortic valve replacement (TAVR) has rapidly displaced surgical aortic valve replacement (SAVR). However, certain post-TAVR complications persist, with cardiac conduction abnormalities (CCA) being one of the major ones. The elevated pressure exerted by the TAVR stent onto the conduction fibers situated between the aortic annulus and the His bundle, in proximity to the atrioventricular (AV) node, may disrupt the cardiac conduction leading to the emergence of CCA. In this study, an <i>in silico</i> framework was developed to assess the CCA risk, incorporating the effect of a dynamic beating heart and preprocedural parameters such as implantation depth and preexisting cardiac asynchrony in the new onset of post-TAVR CCA. A self-expandable TAVR device deployment was simulated inside an electromechanically coupled beating heart model in five patient scenarios, including three implantation depths and two preexisting cardiac asynchronies: (i) a right bundle branch block (RBBB) and (ii) a left bundle branch block (LBBB). Subsequently, several biomechanical parameters were analyzed to assess the post-TAVR CCA risk. The results manifested a lower cumulative contact pressure on the conduction fibers following TAVR for aortic deployment (0.018 MPa) compared to nominal condition (0.29 MPa) and ventricular deployment (0.52 MPa). Notably, the preexisting RBBB demonstrated a higher cumulative contact pressure (0.34 MPa) compared to the nominal condition and preexisting LBBB (0.25 MPa). Deeper implantation and preexisting RBBB cause higher stresses and contact pressure on the conduction fibers leading to an increased risk of post-TAVR CCA. Conversely, implantation above the MS landmark and preexisting LBBB reduces the risk.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 1","pages":"29 - 45"},"PeriodicalIF":3.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hamilton principle-based model for diffusion-driven biofilm growth 基于汉密尔顿原理的扩散驱动生物膜生长模型。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-09-30 DOI: 10.1007/s10237-024-01883-x

Felix Klempt, Meisam Soleimani, Peter Wriggers, Philipp Junker

{"title":"A Hamilton principle-based model for diffusion-driven biofilm growth","authors":"Felix Klempt, Meisam Soleimani, Peter Wriggers, Philipp Junker","doi":"10.1007/s10237-024-01883-x","DOIUrl":"10.1007/s10237-024-01883-x","url":null,"abstract":"<div><p>Dense communities of bacteria, also known as biofilms, are ubiquitous in all of our everyday life. They are not only always surrounding us, but are also active inside our bodies, for example in the oral cavity. While some biofilms are beneficial or even necessary for human life, others can be harmful. Therefore, it is highly important to gain an in-depth understanding of biofilms which can be achieved by <i>in vitro</i> or <i>in vivo</i> experiments. Since these experiments are often time-consuming or expensive, <i>in silico</i> models have proven themselves to be a viable tool in assisting the description and analysis of these complicated processes. Current biofilm growth simulations are using mainly two approaches for describing the underlying models. The volumetric approach splits the deformation tensor into a growth and an elastic part. In this approach, the mass never changes, unless some additional constraints are enforced. The density-based approach, on the other hand, uses an evolution equation to update the growing tissue by adding mass. Here, the density stays constant, and no pressure is exerted. The <i>in silico</i> model presented in this work combines the two approaches. Thus, it is possible to capture stresses inside of the biofilm while adding mass. Since this approach is directly derived from Hamilton’s principle, it fulfills the first and second law of thermodynamics automatically, which other models need to be checked for separately. In this work, we show the derivation of the model as well as some selected numerical experiments. The numerical experiments show a good phenomenological agreement with what is to be expected from a growing biofilm. The numerical behavior is stable, and we are thus capable of solving complicated boundary value problems. In addition, the model is very reactive to different input parameters, thereby different behavior of various biofilms can be captured without modifying the model.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"23 6","pages":"2091 - 2113"},"PeriodicalIF":3.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-024-01883-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiscale computational analysis of the steady fluid flow through a lymph node 对流经淋巴结的稳定流体进行多尺度计算分析。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-09-25 DOI: 10.1007/s10237-024-01879-7

Alberto Girelli, Giulia Giantesio, Alessandro Musesti, Raimondo Penta

{"title":"Multiscale computational analysis of the steady fluid flow through a lymph node","authors":"Alberto Girelli, Giulia Giantesio, Alessandro Musesti, Raimondo Penta","doi":"10.1007/s10237-024-01879-7","DOIUrl":"10.1007/s10237-024-01879-7","url":null,"abstract":"<div><p>Lymph Nodes (LNs) are crucial to the immune and lymphatic systems, filtering harmful substances and regulating lymph transport. LNs consist of a lymphoid compartment (LC) that forms a porous bulk region, and a subcapsular sinus (SCS), which is a free-fluid region. Mathematical and mechanical challenges arise in understanding lymph flow dynamics. The highly vascularized lymph node connects the lymphatic and blood systems, emphasizing its essential role in maintaining the fluid balance in the body. In this work, we describe a mathematical model in a steady setting to describe the lymph transport in a lymph node. We couple the fluid flow in the SCS governed by an incompressible Stokes equation with the fluid flow in LC, described by a model obtained by means of asymptotic homogenisation technique, taking into account the multiscale nature of the node and the fluid exchange with the blood vessels inside it. We solve this model using numerical simulations and we analyze the lymph transport inside the node to elucidate its regulatory mechanisms and significance. Our results highlight the crucial role of the microstructure of the lymph node in regularising its fluid balance. These results can pave the way to a better understanding of the mechanisms underlying the lymph node’s multiscale functionalities which can be significantly affected by specific physiological and pathological conditions, such as those characterising malignant tissues.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"23 6","pages":"2005 - 2023"},"PeriodicalIF":3.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-024-01879-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D growth and remodeling theory supports the hypothesis of staphyloma formation from local scleral weakening under normal intraocular pressure 三维生长和重塑理论支持在正常眼压下巩膜局部变弱形成葡萄状瘤的假设。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-09-25 DOI: 10.1007/s10237-024-01885-9

Fabian A. Braeu, Stéphane Avril, Michaël J. A. Girard

{"title":"3D growth and remodeling theory supports the hypothesis of staphyloma formation from local scleral weakening under normal intraocular pressure","authors":"Fabian A. Braeu, Stéphane Avril, Michaël J. A. Girard","doi":"10.1007/s10237-024-01885-9","DOIUrl":"10.1007/s10237-024-01885-9","url":null,"abstract":"<div><p>The purpose of this study was to assess whether growth and remodeling (G&R) theory could explain staphyloma formation from a local scleral weakening—as could occur from age-related elastin degradation, myopia progression, or other factors. A finite element model of a healthy eye was reconstructed, including the lamina cribrosa, the peripapillary sclera, and the peripheral sclera. The homogenized constrained mixture model was employed to simulate the adaptation of the sclera to alterations in its biomechanical environment over a duration of 13.7 years. G&R processes were triggered by reducing the shear stiffness of the ground matrix in the peripapillary sclera and lamina cribrosa by 85%. Three distinct G&R scenarios were investigated: (1) low mass turnover rate in combination with transmural volumetric growth; (2) high mass turnover rate in combination with transmural volumetric growth; and (3) high mass turnover rate in combination with mass density growth. In <b>scenario 1</b>, we observed a significant outpouching of the posterior pole, closely resembling the shape of a Type-III staphyloma. Additionally, we found a notable change in scleral curvature and a thinning of the peripapillary sclera by 84%. In contrast, <b>scenario 2</b> and <b>3</b> exhibited less drastic deformations, with stable posterior staphylomas after approximately 7 years. Our proposed framework suggests that local scleral weakening is sufficient to trigger staphyloma formation under a normal level of intraocular pressure. Our model also reproduced characteristics of Type-III staphylomas. With patient-specific scleral geometries (as could be obtained with wide-field optical coherence tomography), our framework could be clinically translated to help us identify those at risks of developing posterior staphylomas.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"23 6","pages":"2137 - 2154"},"PeriodicalIF":3.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of shear stress imposed on alveolar epithelium of healthy and diseased lungs 对健康肺和患病肺的肺泡上皮施加的剪切应力进行预测。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-09-21 DOI: 10.1007/s10237-024-01889-5

Alexandros Livanos, Konstantinos Bouchoris, Kyriaki-Evangelia Aslani, Konstantinos Gourgoulianis, Vasilis Bontozoglou

引用次数: 0