Biomechanics and Modeling in Mechanobiology最新文献_第6页

Evaluation of the transjugular intrahepatic portosystemic shunt (TIPS) surgical strategies: a computational fluid dynamics perspective 经颈静脉肝内门静脉系统分流术（TIPS）手术策略的评估：计算流体动力学视角。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-05 DOI: 10.1007/s10237-025-01970-7

Baopeng Wu, Hao Han, Jing Yao, Lingyu Jiang, Jian Yang, Ying Xin, Runxin Fang, Lingling Wei, Shicheng He, Zhiyong Li, Qiang Chen

{"title":"Evaluation of the transjugular intrahepatic portosystemic shunt (TIPS) surgical strategies: a computational fluid dynamics perspective","authors":"Baopeng Wu, Hao Han, Jing Yao, Lingyu Jiang, Jian Yang, Ying Xin, Runxin Fang, Lingling Wei, Shicheng He, Zhiyong Li, Qiang Chen","doi":"10.1007/s10237-025-01970-7","DOIUrl":"10.1007/s10237-025-01970-7","url":null,"abstract":"<div><p>Transjugular intrahepatic portosystemic shunt (TIPS) surgery is commonly employed to treat the portal hypertension (PH), and an appropriate surgical strategy is crucial to balance the surgical outcome and post-TIPS complications. This study numerically explored the effects of six TIPS surgical strategies on the shunt outcome and PV stenosis risk by considering three stent insertion positions with two in-vessel covered lengths from the perspective of the hemodynamics. Sequential CT images of 21 PH subjects were used to reconstruct the six kinds of virtual TIPS surgical models with 6 mm stent and further to compare their five post-TIPS hemodynamic indexes. According to four of the five indexes, it was found that although there was no significant difference between the six surgical strategies, the stent insertion into the main portal vein (MPV) with in-vessel covered length 0 cm was slightly better to reduce the PV pressure, improve the shunt outcome, and potentially decrease the post-TIPS PV stenosis risk. The current findings could be helpful for clinical applications in the aspect of selecting TIPS surgical strategy to treat the PH.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1327 - 1341"},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomorphoelasticity alone: limitations in modeling post-burn contraction and hypertrophy without finite strains 单独的生物形态弹性：在没有有限应变的情况下模拟烧伤后收缩和肥厚的局限性。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-05 DOI: 10.1007/s10237-025-01969-0

Ginger Egberts, Fred Vermolen, Paul van Zuijlen

{"title":"Biomorphoelasticity alone: limitations in modeling post-burn contraction and hypertrophy without finite strains","authors":"Ginger Egberts, Fred Vermolen, Paul van Zuijlen","doi":"10.1007/s10237-025-01969-0","DOIUrl":"10.1007/s10237-025-01969-0","url":null,"abstract":"<div><p>We present a continuum hypothesis-based two-dimensional biomorphoelastic model describing post-burn scar hypertrophy and contraction. The model is based on morphoelasticity for permanent deformations and combined with a chemical-biological model that incorporates cellular densities, collagen density, and the concentration of chemoattractants. We perform a sensitivity analysis for the independent parameters of the model and focus on the effects on the features of the post-burn dermal thickness given a low myofibroblast apoptosis rate. We conclude that the most sensitive parameters are the equilibrium collagen concentration, the signaling molecule secretion rate and the cell force constant, and link these results to stability constraints. Next, we observe a relationship between the simulated contraction and hypertrophy and show the effects for significant variations in the myofibroblast apoptosis rate (high/low). Our ultimate goal is to optimize post-burn treatments, by developing models that predict with a high degree of certainty. We consider the presented model and sensitivity analysis to be a step toward their construction.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1313 - 1326"},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of anisotropic mechanical response of human skin: insights from a clinical trial 评估人体皮肤的各向异性机械反应：来自临床试验的见解。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-02 DOI: 10.1007/s10237-025-01955-6

Aflah Elouneg, Arnaud Lejeune, Gwenaël Rolin, Thomas Lihoreau, Brice Chatelain, Stéphane Bordas, Emmanuelle Jacquet, Jérôme Chambert

{"title":"Assessment of anisotropic mechanical response of human skin: insights from a clinical trial","authors":"Aflah Elouneg, Arnaud Lejeune, Gwenaël Rolin, Thomas Lihoreau, Brice Chatelain, Stéphane Bordas, Emmanuelle Jacquet, Jérôme Chambert","doi":"10.1007/s10237-025-01955-6","DOIUrl":"10.1007/s10237-025-01955-6","url":null,"abstract":"<div><p>This paper presents findings from the SKin Uncertainties Modeling (SKUM) clinical trial aimed at assessing the anisotropic mechanical response of human skin using the annular suction test, employing a numerical method and a commercial device, CutiScan<sup>®</sup> CS 100. A cohort of 30 healthy volunteers participated in the trial, undergoing in vivo testing on the left forearm through a multi-axial stretch induced by ring suction. Determination of the anisotropy axis was performed using a numerical method based on model fitting of experimental data obtained from oriented elliptic curves, which resulted from the radial deformation of circles. The study evaluates the reproducibility and variability of measurements through an intra-subject study involving five participants, providing insights into the consistency of results within individuals. Additionally, an inter-subject analysis across all subjects offers a comprehensive understanding of anisotropy variability, elucidating broader population tendencies. Furthermore, the study explores correlations between anisotropy and demographic factors such as sex, age, and skin thickness, shedding light on potential influences on skin biomechanics. The analysis showed significant correlations between skin anisotropy and sex, with males displaying a distinct anisotropy axis orientation compared to females. In contrast, no significant associations were found between anisotropy and age among individuals aged 20–50, or between anisotropy and epidermal thickness.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 3","pages":"1085 - 1102"},"PeriodicalIF":2.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A reduced 3D-0D fluid–structure interaction model of the aortic valve that includes leaflet curvature 包含小叶曲率的主动脉瓣三维流固耦合模型。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 DOI: 10.1007/s10237-025-01960-9

Ivan Fumagalli, Luca Dede’, Alfio Quarteroni

{"title":"A reduced 3D-0D fluid–structure interaction model of the aortic valve that includes leaflet curvature","authors":"Ivan Fumagalli, Luca Dede’, Alfio Quarteroni","doi":"10.1007/s10237-025-01960-9","DOIUrl":"10.1007/s10237-025-01960-9","url":null,"abstract":"<div><p>We introduce an innovative lumped-parameter model of the aortic valve, designed to efficiently simulate the impact of valve dynamics on blood flow. Our reduced model includes the elastic effects associated with the leaflets’ curvature and the stress exchanged with the blood flow. The introduction of a lumped-parameter model based on momentum balance entails an easier calibration of the model parameters: Phenomenological-based models, on the other hand, typically have numerous parameters. This model is coupled to 3D Navier–Stokes equations describing the blood flow, where the moving valve leaflets are immersed in the fluid domain by a resistive method. A stabilized finite element method with a BDF time scheme is adopted for the discretization of the coupled problem, and the computational results show the suitability of the system in representing the leaflet motion, the blood flow in the ascending aorta, and the pressure jump across the leaflets. Both physiological and stenotic configurations are investigated, and we analyze the effects of different treatments for the leaflet velocity on the blood flow.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1169 - 1189"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transit time mean and variance are markers of vascular network structure, wall shear stress distribution and oxygen extraction fraction 传递时间均值和方差是血管网络结构、壁面剪应力分布和氧萃取率的标志。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-05-27 DOI: 10.1007/s10237-025-01959-2

Stephen J. Payne, Yidan Xue, Jen-Feng Kuo, Wahbi K. El-Bouri

{"title":"Transit time mean and variance are markers of vascular network structure, wall shear stress distribution and oxygen extraction fraction","authors":"Stephen J. Payne, Yidan Xue, Jen-Feng Kuo, Wahbi K. El-Bouri","doi":"10.1007/s10237-025-01959-2","DOIUrl":"10.1007/s10237-025-01959-2","url":null,"abstract":"<div><p>Perfusion measurements provide information about flow magnitude, but more detailed information is found from transit time distributions (TTD). Whether TTDs provide intrinsic (flow-independent) information about vascular geometry or just flow field remains unknown. We propose a new approach to calculate TTD, based on wall shear stress (WSS). We show that constant WSS yields zero-variance TTD. Simulations in statistical networks show that mean transit time (MTT) and capillary transit time heterogeneity (CTH) are primarily determined by pathway number distribution rather than pressure drop distribution. Using 1000 statistically generated cortical columns, we show that (1) the central volume theorem provides a very good approximation for MTT, hence is a measure of tissue permeability; (2) CTH/MTT ratio, RTH (relative transit time heterogeneity), is a marker of WSS variability; and (3) RTH is inversely related to network oxygen extraction fraction (OEF) but only weakly related to MTT. RTH is below one in animal models, but above one in humans, indicating that WSS distribution is tighter in small animals (lower RTH and higher OEF), due to higher metabolic rate. Human WSS distribution appears to be an inherent property, since simulations show much larger RTH. Finally, WSS distribution is unaffected in ageing, but altered in pathology.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1155 - 1167"},"PeriodicalIF":2.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational construction and design optimization of a novel tri-tube heart valve 新型三管心脏瓣膜的计算构造与设计优化。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-05-26 DOI: 10.1007/s10237-025-01956-5

Jirong Li, Yijiang Yu, Robert T. Tranquillo

{"title":"Computational construction and design optimization of a novel tri-tube heart valve","authors":"Jirong Li, Yijiang Yu, Robert T. Tranquillo","doi":"10.1007/s10237-025-01956-5","DOIUrl":"10.1007/s10237-025-01956-5","url":null,"abstract":"<div><p>A finite-element-based algorithm for the in silico construction of a novel tri-tube heart valve was developed to facilitate optimization of the leaflet geometry. An anisotropic hyperelastic model fitted to high-strain rate planar equibiaxial tension and compression data was used to approximate the nonlinear and anisotropic material behavior of biologically-engineered tubes and simulate valve closure under steady back pressure and steady forward flow. Four metrics were considered to evaluate valve performance in simulated closure: coaptation area, regurgitation area, pinwheel index, and prolapse area. Response surfaces revealed competing objectives between metrics for a valve of target 24 mm diameter in terms of two design parameters, tube diameter and leaflet height. A multi-objective genetic algorithm determined an intermediate tube diameter and leaflet height (16 mm and 11 mm, respectively) of the design space as optimal. Additionally, steady flow simulations were performed using two-way fluid–structure interaction with selected designs to examine washout behind leaflets with particle tracking. One design close to the optimal point for valve closure indicated washout for particles initially distributed behind leaflets. Though comprehensive valve design optimization requires flow analysis over multiple valve cycles to capture all effects associated with flow, this methodology based on diastolic state geometry optimization followed by steady washout analysis reduces the space of design variables for further optimization.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 3","pages":"1103 - 1121"},"PeriodicalIF":2.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional variability in craniofacial stiffness: a study in normal and Crouzon mice during postnatal development 颅面硬度的区域变异性：出生后发育期间正常小鼠和Crouzon小鼠的研究。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-05-25 DOI: 10.1007/s10237-025-01962-7

Marius Didziokas, Miranda Steacy, Tengyang Qiu, Arsalan Marghoub, Ali Alazmani, Erwin Pauws, Mehran Moazen

{"title":"Regional variability in craniofacial stiffness: a study in normal and Crouzon mice during postnatal development","authors":"Marius Didziokas, Miranda Steacy, Tengyang Qiu, Arsalan Marghoub, Ali Alazmani, Erwin Pauws, Mehran Moazen","doi":"10.1007/s10237-025-01962-7","DOIUrl":"10.1007/s10237-025-01962-7","url":null,"abstract":"<div><p>Craniosynostosis (CS) is the premature closure of craniofacial joints known as sutures. Typically, this condition is treated by numerous invasive surgical interventions. Previously we investigated the level of mechanical strain induced due to frontal bone loading on a mouse model of this condition in light of a minimally invasive cyclic bone loading, showing success in retaining coronal suture patency in the Crouzon mouse model. Here we expanded on the previous investigations and characterised the response to external loading on the anterior part of the parietal bone, posterior part of the parietal bone and interparietal bone in addition to the previously investigated frontal bone loading. The results highlighted the significantly higher deformation of the skull and cranial joints during loading of the posterior skull compared to anterior skull loading. These results suggest that loading-based treatment requires different loading regimes depending on location. Additionally, the response of the coronal suture was investigated directly at postnatal day 7 (P7) in both mutant and wild-type animals. The wild-type mice exhibited significant deformation of the coronal suture across all loading locations, whereas no significant deformation was observed in the mutants. Finally, the experimental results were utilised to develop and analyse computational models of WT mice at three ages: P7, P14, and P21. This underscored the challenges in accurately capturing the highly variable response of the mouse craniofacial system to external loading. In summary, this work provided more details on the mechanics of the mouse craniofacial system and its variable overall stiffness across the different anatomical regions of the skull.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1207 - 1222"},"PeriodicalIF":2.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the biomechanical effects of severe anterior disc displacement on the temporomandibular joint and occlusion 重度前椎间盘移位对颞下颌关节和咬合的生物力学影响的研究。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-05-22 DOI: 10.1007/s10237-025-01965-4

Chunxin Yang, Tinghui Sun, Bingmei Shao, Zhan Liu

{"title":"Investigation of the biomechanical effects of severe anterior disc displacement on the temporomandibular joint and occlusion","authors":"Chunxin Yang, Tinghui Sun, Bingmei Shao, Zhan Liu","doi":"10.1007/s10237-025-01965-4","DOIUrl":"10.1007/s10237-025-01965-4","url":null,"abstract":"<div><p>The temporomandibular joint (TMJ) and occlusion, as critical load-bearing components of the stomatognathic system, exhibit complex interdependence. While occlusal abnormalities contribute to internal joint disorders, their reciprocal effects remain poorly understood. This study investigates how severe anterior disc displacement (ADD) alters the stress distribution within the TMJ and the occlusion, aiming to elucidate the TMJ–occlusion relationship and inform clinical diagnosis and treatment strategies. Refined finite element models of the masticatory system of the normal, bilaterally severe ADD, and unilaterally severe ADD groups were developed. Stress distributions were analyzed under maximum voluntary intercuspal clenching (MIC) and maximum voluntary unilateral molar clenching (MUC) with corresponding muscle force intensities. Results showed that under high-intensity clenching, the contact stress on the second molars in the severe ADD groups (48.4–50.3 MPa) exceeded that in the normal group (37.7–38.4 MPa). The condylar contact stress of the severe ADD group was more than 40 times greater than that of the normal group. The ranking of peak stresses on the condyles with unilateral severe ADD under different high-intensity tasks was as follows: MUCI (336.97 MPa) > MUCC (206.54 MPa) > MIC (169.19 MPa). In conclusion, severe ADD under high-intensity clenching induces anterior slippage of discs, resulting in abnormal stress concentrations on the condyles and second molars, particularly during ipsilateral clenching. To mitigate potential biomechanical risks, patients are encouraged to adopt balanced mastication habits.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1267 - 1277"},"PeriodicalIF":2.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Bifurcation Morphology on Exercise-Induced PAH Deposition in the Lungs: A Computational Modeling Approach for Air Quality Research 分岔形态对运动诱导的肺内多环芳烃沉积的影响：空气质量研究的计算建模方法。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-05-21 DOI: 10.1007/s10237-025-01968-1

Justus Kavita Mutuku, Hsin-Chieh Kung, Wei-Hsin Chen, Chien-Er Huang, Kuan Shiong Khoo, Pau Loke Show

{"title":"Influence of Bifurcation Morphology on Exercise-Induced PAH Deposition in the Lungs: A Computational Modeling Approach for Air Quality Research","authors":"Justus Kavita Mutuku, Hsin-Chieh Kung, Wei-Hsin Chen, Chien-Er Huang, Kuan Shiong Khoo, Pau Loke Show","doi":"10.1007/s10237-025-01968-1","DOIUrl":"10.1007/s10237-025-01968-1","url":null,"abstract":"<div><p>This study examines the influence of lung geometry, physical activity intensity, and aerosol concentration on the deposition efficiencies (DEs) of particulate matter with surface-bound polycyclic aromatic hydrocarbons (PM-<sub>PAHs</sub>) in human lung generations 3–6. Two-phase flows were effected in ANSYS 2020R2 platform using planar and orthogonal lung geometries, with two levels of physical activities, 4 metabolic equivalents (4 METs), and 8 METs. Aerosol concentrations of 0.95 μg‧m<sup>−3</sup>, 1.57 μg‧m<sup>−3</sup>, and 2.04 μg‧m<sup>−3</sup> represent rural, urban, and industrial areas, respectively. Relative differences in DEs for 1 μm, 3.2 μm, and 5.6 μm exhibit variations between the two geometries with ranges of 0%–84.4% for 4 METs and 1.2%–50.7% for 8 METs. The first carina region was the most significant hotspot for the 5.6 μm particles. On the other hand, the 1 μm and 3.2 μm aerosols infiltrated and deposited evenly at the lower sections of the lungs. Regarding PM-<sub>PAHs</sub> doses, spatial variations indicate an industrial > urban > rural hierarchy. This investigation suggests that individuals in industrial and urban locations should manage the intensity of their outdoor activities to minimize exposure to PM-<sub>PAHs</sub>. These findings are instrumental for public health interventions aimed at reducing exposure to PM-<sub>PAHs</sub> and preventing associated health problems.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 4","pages":"1295 - 1312"},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A quantitative review of finite element-based biomechanics of lumbar decompression surgery 腰椎减压手术中基于有限元的生物力学定量综述。

IF 2.7 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-05-20 DOI: 10.1007/s10237-025-01936-9

Mary H. Foltz, Alexandra H. Seidenstein, Craig Almeida, Andrew Kim, Amit Jain, Jill M. Middendorf

{"title":"A quantitative review of finite element-based biomechanics of lumbar decompression surgery","authors":"Mary H. Foltz, Alexandra H. Seidenstein, Craig Almeida, Andrew Kim, Amit Jain, Jill M. Middendorf","doi":"10.1007/s10237-025-01936-9","DOIUrl":"10.1007/s10237-025-01936-9","url":null,"abstract":"<div><p>Lumbar decompression surgeries are commonly performed in the USA to treat pain from spinal stenosis, often with little to no biomechanical evidence to evaluate the risks and benefits of a given surgery. Finite element models of lumbar spinal decompression surgeries attempt to elucidate the biomechanical benefits and risks of these procedures. Each published finite element model uses a unique subset of lumbar decompression surgeries, a unique human lumbar spine, and unique model inputs. Thus, drawing conclusions about biomechanical changes and biomechanical complications due to surgical variations is difficult. This quantitative review performed an analysis on the stresses, forces, and range of motion reported in lumbar spine finite element models that focus on spinal decompression surgeries. To accomplish this analysis, data from finite elements models of lumbar decompression surgeries published between 2000 and December 2023 were normalized to the intact spine and compared. This analysis indicated that increased bony resection and increased ligament resection are associated with increased pathologic range of motion compared to limited resection techniques. Further, a few individual studies show an increase in important outcomes such IVD stresses, pars interarticularis stresses, and facet joint forces due to decompression surgery, but the small number of published models with these results limits the generalizability of these findings to the general population. Future FE models should report these spinal stresses and incorporate patient-specific anatomical features such as IVD health, facet geometry, stenosis patient vertebrae, and vertebral porosity into the model.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 3","pages":"743 - 759"},"PeriodicalIF":2.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0