Biomechanics and Modeling in Mechanobiology最新文献_第6页

Multistep model reduction of coagulation schemes. 混凝方案的多步模型还原。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-06-01 Epub Date: 2025-04-07 DOI: 10.1007/s10237-025-01944-9

Junyi Chen, Quentin Cazères, Eleonore Riber, Franck Nicoud

引用次数: 0

Computational model of coarctation of the aorta in rabbits suggests persistent ascending aortic remodeling post-correction 兔主动脉缩窄的计算模型显示，矫正后升主动脉持续重构。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-03-20 DOI: 10.1007/s10237-025-01933-y

Ashley A. Hiebing, Matthew A. Culver, John F. LaDisa Jr., Colleen M. Witzenburg

{"title":"Computational model of coarctation of the aorta in rabbits suggests persistent ascending aortic remodeling post-correction","authors":"Ashley A. Hiebing, Matthew A. Culver, John F. LaDisa Jr., Colleen M. Witzenburg","doi":"10.1007/s10237-025-01933-y","DOIUrl":"10.1007/s10237-025-01933-y","url":null,"abstract":"<div><p>Coarctation of the aorta (CoA) is a common congenital cardiovascular lesion that presents as a localized narrowing of the proximal descending aorta. While improvements in surgical and catheter-based techniques have increased short-term survival, there is a high long-term risk of hypertension and a reduced average lifespan despite correction. Computational models can be used to estimate aortic remodeling and peripheral vascular compensation, potentially serving as key tools in developing a mechanistic understanding of the interplay between pre-treatment dynamics, post-treatment recovery, and long-term hypertension risk. In this study, we developed a lumped-parameter model of the heart and circulation to simulate CoA. After fitting model parameters using imaging and catheterization data from healthy rabbits, we then used the model to estimate differences in ascending aortic compliance and peripheral resistance between the healthy group and rabbits with both untreated and corrected CoA using their imaging and catheterization data. CoA was defined by the current putative clinical treatment threshold (a pressure gradient > 20 mm Hg). Model inputs were fitted such that outputs matched reported stroke volume, ejection fraction, systolic and diastolic aortic pressure, peak aortic flow, mean and peak blood pressure gradients, and upper-to-lower body flow split, with all results falling within one standard deviation of the data for all groups. In the untreated CoA and corrected simulations, a decrease in ascending aortic compliance was necessary to match reported hemodynamics. This suggests exposure to a pressure gradient > 20 mm Hg results in vascular remodeling that persists after repair, a process strongly correlated with hypertension.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 2","pages":"683 - 700"},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Numerical simulation of voluntary respiration in a model of the whole human lower airway 在整个人体下气道模型中对自主呼吸进行数值模拟。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-03-17 DOI: 10.1007/s10237-025-01932-z

Xinying Ou, Jiahuan Meng, Chen Ma, Huajing Wan, Yu Chen, Fengming Luo

{"title":"Numerical simulation of voluntary respiration in a model of the whole human lower airway","authors":"Xinying Ou, Jiahuan Meng, Chen Ma, Huajing Wan, Yu Chen, Fengming Luo","doi":"10.1007/s10237-025-01932-z","DOIUrl":"10.1007/s10237-025-01932-z","url":null,"abstract":"<div><p>The lung model construction is limited to the local scale, and the numerical simulation of autonomous breathing is mostly computed from top to bottom in recent research. In this study, models of the entire lower airway from G0–G23 were constructed, and computational simulations were performed for the alveolar model using coupled fluid–solid analysis with pressure changes on the wall and for the rigid bronchial model using computational fluid dynamics by transmitting the boundary conditions step from bottom to top. This paper provides the results under spontaneous respiration, including the ventilation volume of the tracheobronchial tree, the situation of the internal flow field, and the mechanical characteristics of the lung tissues. The mechanical characteristics and the lung functions computed by the models were consistent with clinical or experimental data. This model could provide quantitative analysis results of respiratory mechanics in the lower respiratory tract of the human, which offers a reference for mechanical studies, such as the morphological changes and differentiation of cell types induced by force stimulation and tumor induction. Furthermore, various pathological models can be developed based on this model.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 2","pages":"663 - 681"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The order of precedence in treatment of multiple intracranial aneurysms: insights from a fluid–structure interaction study 治疗多发性颅内动脉瘤的先后顺序：流体与结构相互作用研究的启示。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-03-14 DOI: 10.1007/s10237-025-01928-9

Kornelia M. Kliś, Jerzy Gąsowski, Antoni Cierniak, Borys M. Kwinta, Krzysztof Stachura, Tadeusz J. Popiela, Igor Szydłowski, Bartłomiej Łasocha, Karolina Piotrowicz, Tomasz Grodzicki, Roger M. Krzyżewski

{"title":"The order of precedence in treatment of multiple intracranial aneurysms: insights from a fluid–structure interaction study","authors":"Kornelia M. Kliś, Jerzy Gąsowski, Antoni Cierniak, Borys M. Kwinta, Krzysztof Stachura, Tadeusz J. Popiela, Igor Szydłowski, Bartłomiej Łasocha, Karolina Piotrowicz, Tomasz Grodzicki, Roger M. Krzyżewski","doi":"10.1007/s10237-025-01928-9","DOIUrl":"10.1007/s10237-025-01928-9","url":null,"abstract":"<div><p>Treatment strategy for multiple intracranial aneurysms is challenging, as in many cases the choice of the order in which to treat aneurysms is not based on high-quality evidence. We aimed to digitally simulate clinical scenarios of two different orders in which multiple intracranial aneurysms were treated and analyze changes in hemodynamics after first stage of treatment. We prospectively included patients with two intracranial aneurysms, with order of treatment difficult to determine based on clinical data alone. For each patient we prepared three models of arteries harboring aneurysms: with both aneurysms present and with one of them removed. Computational modeling of blood flow using fluid–structure interaction methodology was performed for each model. Hemodynamic parameters of aneurysm domes were compared between models with both aneurysm present, and models in with aneurysms were removed in changing order. In 25 included patients, the calculated hemodynamic parameters such as Time-Averaged Wall Shear Stress (0.46 ± 0.40 vs. 0.54 ± 0.44 Pa; <i>p</i> < 0.01) and surface vortex fraction (12.73% ± 7.92% vs. 14.26% ± 7.46%; <i>p</i> = 0.02) decreased after first stage of treatment, while Time-Averaged Wall Shear Stress Gradient (1.44 ± 0.41 vs. 1.34 ± 0.46 Pa; <i>p</i> = 0.04) and percentage of wall shear stress < 0.5 Pa (50.13% ± 33.01% vs. 44.08% ± 34.16%; <i>p</i> < 0.01) increased. Changes of wall shear stress in remaining aneurysm dome were independently correlated with dome-to-neck ratio of both removed and remaining aneurysms. Hemodynamics of untreated aneurysm worsens after first stage of treatment. Dome-to-neck ratio of both treated and untreated aneurysm was the strongest and independent predictor of that change.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 2","pages":"589 - 598"},"PeriodicalIF":3.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Static and dynamic optimisation of fluid-filled responsive orthotic insoles 液体填充响应式矫形鞋垫的静态和动态优化。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-03-03 DOI: 10.1007/s10237-025-01935-w

Dayna Cracknell, Mark Battley, Justin Fernandez, Maedeh Amirpour

{"title":"Static and dynamic optimisation of fluid-filled responsive orthotic insoles","authors":"Dayna Cracknell, Mark Battley, Justin Fernandez, Maedeh Amirpour","doi":"10.1007/s10237-025-01935-w","DOIUrl":"10.1007/s10237-025-01935-w","url":null,"abstract":"<div><p>This study was focused on developing an optimisation-based methodology to create customised solid–liquid composite (SLC) orthotic insoles. The goal was to reduce peak plantar pressures through gait through a dynamic numerical optimisation. A gait simulation was developed through a series of numerical models with increasing complexity. These models were validated against experimental analyses. The insole was designed based on numerical optimisation techniques that regionally tailored the insole with the aim to reduce temporal peak pressures. A prototype of the optimised insole was created using additive manufacturing and tested experimentally. The numerical gait simulation showed good correlation with experimental results. The largest differences are attributed to the bone geometry adopted from a previous study from a subject of different age, gender and size demographics. The optimisation process showed significant reductions in peak plantar pressures in the static peak pressures by approximately 8% and in the summation of dynamic peak pressures by 50%. Experimental validation confirmed the numerical predictions, highlighting the effectiveness of the optimised insole. The findings suggest that the optimised insoles can improve plantar pressure distributions and reduce peak pressures, making them a viable alternative to traditional orthotic insoles. Future research should focus on more accurate geometry for the numerical models and clinical trials.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 2","pages":"713 - 741"},"PeriodicalIF":3.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01935-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase-field simulation of crack growth in cortical bone microstructure: parameter identification and comparison against experiments 骨皮质微结构裂纹扩展的相场模拟：参数识别与实验对比。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-03-01 DOI: 10.1007/s10237-025-01929-8

Jenny Carlsson, Olivia Karlsson, Hanna Isaksson, Anna Gustafsson

{"title":"Phase-field simulation of crack growth in cortical bone microstructure: parameter identification and comparison against experiments","authors":"Jenny Carlsson, Olivia Karlsson, Hanna Isaksson, Anna Gustafsson","doi":"10.1007/s10237-025-01929-8","DOIUrl":"10.1007/s10237-025-01929-8","url":null,"abstract":"<div><p>Computational models are commonly used to investigate how the cortical bone microstructure affects fracture resistance; recently, phase-field models have been introduced for this purpose. However, experimentally measured material parameters for the microstructural tissues are lacking. Moreover, as no validation studies have been published, it remains unclear to what extent classical phase-field methods, assuming linear-elastic, brittle fracture, accurately represent bone. In this study, we address both these shortcomings by first applying a design-of-experiments methodology to calibrate a set of material parameters for a two-dimensional phase-field finite element model of bovine osteonal microstructure. This was achieved by comparing the outcomes from simulation to data from single-edge notched bending experiments on bovine osteonal bone and subsequent imaging of the crack path. Second, we used these parameters in new bone geometries to evaluate the parameters and the predictive performance of the model. Reasonable agreement was achieved between prediction and experiments in terms of peak load, crack initiation toughness and crack path. However, the model is unable to capture the experimentally observed gradual evolution of damage, leading to a nonlinear force response before the onset of visible crack extension. Nor does it capture the similarly observed increase in toughness with increasing crack length. These limitations are inherent to all classical phase-field methods since they originate from theories of brittle fracture, and alternative formulations are discussed. This is the first study attempting to validate classical phase-field methods in simulation of cortical bone fracture, and it highlights both potential and limitations to be addressed in future work.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 2","pages":"599 - 613"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01929-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homogenized multiscale modelling of an electrically active double poroelastic material representing the myocardium 代表心肌的电活性双孔弹性材料的均质化多尺度建模。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-02-26 DOI: 10.1007/s10237-025-01931-0

Laura Miller, Raimondo Penta

{"title":"Homogenized multiscale modelling of an electrically active double poroelastic material representing the myocardium","authors":"Laura Miller, Raimondo Penta","doi":"10.1007/s10237-025-01931-0","DOIUrl":"10.1007/s10237-025-01931-0","url":null,"abstract":"<div><p>In this work, we present the derivation of a novel model for the myocardium that incorporates the underlying poroelastic nature of the material constituents as well as the electrical conductivity. The myocardium has a microstructure consisting of a poroelastic extracellular matrix with embedded poroelastic myocytes, i.e. a double poroelastic material. Due to the sharp length scale separation that exists between the microscale, where the individual myocytes are clearly resolved from the surrounding matrix, and the length of the entire heart muscle, we can apply the asymptotic homogenization technique. The novel PDE model accounts for the difference in the electric potentials, elastic properties as well as the differences in the hydraulic conductivities at different points in the microstructure. The differences in these properties are encoded in the coefficients and are to be computed by solving differential cell problems arising when applying the asymptotic homogenization technique. We present a numerical analysis of the obtained Biot’s modulus, Young’s moduli as well as shears and the effective electrical activity. By investigating the poroelastic and electrical nature of the myocardium in one model, we can understand how the differences in elastic displacements between the extracellular matrix and the myocytes affect mechanotransduction and the influence of disease.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 2","pages":"635 - 662"},"PeriodicalIF":3.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01931-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constitutive neural networks for main pulmonary arteries: discovering the undiscovered 肺动脉主干的本构神经网络：发现未被发现的。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-02-24 DOI: 10.1007/s10237-025-01930-1

Thibault Vervenne, Mathias Peirlinck, Nele Famaey, Ellen Kuhl

{"title":"Constitutive neural networks for main pulmonary arteries: discovering the undiscovered","authors":"Thibault Vervenne, Mathias Peirlinck, Nele Famaey, Ellen Kuhl","doi":"10.1007/s10237-025-01930-1","DOIUrl":"10.1007/s10237-025-01930-1","url":null,"abstract":"<div><p>Accurate modeling of cardiovascular tissues is crucial for understanding and predicting their behavior in various physiological and pathological conditions. In this study, we specifically focus on the pulmonary artery in the context of the Ross procedure, using neural networks to discover the most suitable material model. The Ross procedure is a complex cardiac surgery where the patient’s own pulmonary valve is used to replace the diseased aortic valve. Ensuring the successful long-term outcomes of this intervention requires a detailed understanding of the mechanical properties of pulmonary tissue. Constitutive artificial neural networks offer a novel approach to capture such complex stress–strain relationships. Here, we design and train different constitutive neural networks to characterize the hyperelastic, anisotropic behavior of the main pulmonary artery. Informed by experimental biaxial testing data under various axial-circumferential loading ratios, these networks autonomously discover the inherent material behavior, without the limitations of predefined mathematical models. We regularize the model discovery using cross-sample feature selection and explore its sensitivity to the collagen fiber distribution. Strikingly, we uniformly discover an isotropic exponential first-invariant term and an anisotropic quadratic fifth-invariant term. We show that constitutive models with both these terms can reliably predict arterial responses under diverse loading conditions. Our results provide crucial improvements in experimental data agreement, and enhance our understanding into the biomechanical properties of pulmonary tissue. The model outcomes can be used in a variety of computational frameworks of autograft adaptation, ultimately improving the surgical outcomes after the Ross procedure.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 2","pages":"615 - 634"},"PeriodicalIF":3.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01930-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher-order thermal modeling and computational analysis of laser ablation in anisotropic cardiac tissue 各向异性心脏组织激光消融的高阶热建模与计算分析。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-02-24 DOI: 10.1007/s10237-025-01926-x

Federica Bianconi, Massimiliano Leoni, Argyrios Petras, Emiliano Schena, Luca Gerardo-Giorda, Alessio Gizzi

{"title":"Higher-order thermal modeling and computational analysis of laser ablation in anisotropic cardiac tissue","authors":"Federica Bianconi, Massimiliano Leoni, Argyrios Petras, Emiliano Schena, Luca Gerardo-Giorda, Alessio Gizzi","doi":"10.1007/s10237-025-01926-x","DOIUrl":"10.1007/s10237-025-01926-x","url":null,"abstract":"<div><p>Laser ablation techniques employ fast hyperthermia mechanisms for diseased-tissue removal, characterized by high selectivity, thus preserving the surrounding healthy tissue. The associated modeling approaches are based on classical Fourier-type laws, though a limited predictivity is observed, particularly at fast time scales. Moreover, limited knowledge is available for cardiac tissue compared to radiofrequency approaches. The present work proposes a comprehensive modeling approach for the computational investigation of the key factors involved in laser-based techniques and assessing the outcomes of induced cellular thermal damage in the cardiac context. The study encompasses a comparative finite element study involving various thermal and cellular damage models incorporating optical–thermal couplings, three-state cellular death dynamics, and a second-order heat transfer formulation generalizing the classical Fourier-based heat equation. A parametric investigation of the thermal profiles shows that higher-order models accurately capture temperature dynamics and lesion formation compared with the classical Fourier-based model. The results highlight the critical role of cardiac anisotropy, influencing the shape and extent of thermal damage, while the three-state cell death model effectively describes the transition from reversible to irreversible damage. These findings demonstrate the reliability of higher-order thermal formulations, laying the basis for future investigations of arrhythmia management via in silico approaches.</p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 2","pages":"559 - 577"},"PeriodicalIF":3.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10237-025-01926-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructural remodeling under single fiber tensional homeostasis recreates distinctive ex vivo mechanical behavior of arteries 单纤维张力稳态下的微结构重塑重建了动脉独特的体外力学行为。

IF 3 3区医学

Biomechanics and Modeling in Mechanobiology Pub Date : 2025-02-23 DOI: 10.1007/s10237-025-01934-x

Ruturaj M. Badal, Ryan R. Mahutga, Patrick W. Alford, Victor H. Barocas

{"title":"Microstructural remodeling under single fiber tensional homeostasis recreates distinctive ex vivo mechanical behavior of arteries","authors":"Ruturaj M. Badal, Ryan R. Mahutga, Patrick W. Alford, Victor H. Barocas","doi":"10.1007/s10237-025-01934-x","DOIUrl":"10.1007/s10237-025-01934-x","url":null,"abstract":"<div><p>The arterial wall is a structurally complex material, exhibiting both nonlinearity and anisotropy in its mechanics, with the compelling consequence that the end plate force in a pressure-stretch experiment can increase or decrease with pressure depending on the axial stretch of the vessel. Furthermore, it has long been observed that the axial stretch at which the ex vivo pressure-force curve is flat is close to the in vivo axial stretch, but the mechanism driving this phenomenon has remained unclear. By employing and modifying a custom plugin that represents tissue components as networks, we computationally tested the hypothesis that tensional homeostasis at the microscopic scale could lead to the macroscopic pressure-invariant axial force effect observed at in vivo axial stretch. Our findings suggest that remodeling events for individual fibers to achieve a target stress can, acting in aggregate, cause the vessel to exhibit a pressure-invariant axial force in the pressure-force experiment without any explicit sensing of the pressure-force behavior during remodeling. Computational isolation of tissue components suggested that remodeling of collagen fibers is a primary driver of this result. Further as long seen experimentally, the pressure-force curve plateau occurred at stretches close to the in vivo remodeling stretch. </p></div>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":"24 2","pages":"701 - 712"},"PeriodicalIF":3.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0