Multistep model reduction of coagulation schemes.

Abstract

This study introduces a comprehensive multistep reduction technique for coagulation models, specifically targeting the dynamics of thrombin generation. By employing a synergistic approach that combines direct relation graph with error propagation, chemical lumping, quasi-steady-state assumption, and conservation analysis, the method efficiently reduces the complexity of original coagulation models without compromising accuracy. Applied to both extrinsic and intrinsic coagulation pathway schemes, this approach significantly diminishes the number of species and reactions, and the resulting reduced schemes appear to be robust to changes in initial conditions relevant to hemophilia A. The findings underscore the potential of this reduction method to facilitate more efficient computational simulations that retain the essential characteristics of different coagulation models.