Dental Materials最新文献

{"title":"A chlorinated mussel-inspired monomer stabilizes dentin via anti-proteolysis and collagen cross-linking.","authors":"Na Ouyang, Canwen Zhang, Leqi Yang, Haoyu Jiang, Yu Zhang, Kang Li","doi":"10.1016/j.dental.2026.08.015","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.015","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether the novel monomer N-(2-chloro-4,5-dihydroxyphenethyl) methacrylamide (Cl-DMA) provides dual anti-proteolytic and collagen cross-linking effects on demineralized dentin matrices.</p><p><strong>Methods: </strong>A 10% ethanol/water solution served as the vehicle control, and Cl-DMA solutions were prepared at concentrations of 1, 10, and 100 mM. A 10 mM chlorhexidine acetate (CHX) solution and a 10 mM glutaraldehyde (GA) solution served as positive controls for anti-proteolytic and cross-linking effects, respectively. Inhibitory effects on matrix metalloproteinases (MMP-2, -8, -9) and Clostridium histolyticum collagenase were assessed using enzyme activity kits. In situ zymography with confocal laser scanning microscopy (CLSM) quantified MMP activity at the bonding interface. Demineralized human dentin beams treated with these solutions for 1 h were evaluated for dry mass loss, hydroxyproline release, and swelling ratio. Collagen fibril ultrastructure was observed via FESEM, while Cl-DMA/collagen binding characteristics were analyzed using ATR-FTIR spectroscopy. Molecular docking simulated the binding modes of Cl-DMA and CHX with MMPs.</p><p><strong>Results: </strong>Cl-DMA inhibited protease activity in a generally concentration-dependent manner. While 10 mM Cl-DMA exhibited weaker inhibition of soluble MMPs than CHX, in situ zymography revealed that 10 and 100 mM Cl-DMA significantly inhibited interfacial MMP activity, comparable to CHX. Furthermore, 100 mM Cl-DMA significantly reduced dry mass loss, hydroxyproline release, and swelling ratio. FESEM indicated decreased porosity and increased compactness of the collagen network with higher Cl-DMA concentrations. FTIR confirmed non-covalent hydrogen bond cross-linking without triple-helix disruption. Molecular docking results demonstrated that Cl-DMA could bind to MMP-2, -8, and -9, though with weaker binding affinities than CHX.</p><p><strong>Significance: </strong>Cl-DMA effectively inhibited protease activity and promoted collagen cross-linking and stabilization. The 100 mM concentration exhibited the greatest overall efficacy under the present experimental conditions, supporting the potential of Cl-DMA as a multifunctional dentin pretreatment agent for reducing enzymatic degradation of demineralized dentin collagen.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing dentin bonding with catechol-based monomers by tailoring photoinitiator systems to overcome radical inhibition.","authors":"Denghao Fu, Surbhi Punhani-Schillinger, Romina Esmaeilzade, Caroline Szczepanski","doi":"10.1016/j.dental.2026.08.011","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.011","url":null,"abstract":"<p><strong>Objective: </strong>Although catechol-functionalized polymers show promise for improving adhesion in wet environments, these catechol groups also inhibit free-radical polymerization, slowing kinetics, reducing conversion, increasing cytotoxicity, and compromising bonding performance. This study evaluates alternative photoinitiator systems to overcome catechol-induced inhibition in both etch-and-rinse and self-etch adhesives.</p><p><strong>Methods: </strong>Catechol methacrylamide (CMA) was incorporated into a methacrylate-based adhesive resin (0 to 5 wt%) as a partial replacement for the traditionally employed monomer 2-hydroxyethyl methacrylate (HEMA). The photopolymerization behavior of CMA-modified adhesives were investigated with varying photo-initiating systems, including type II photoinitiator systems camphorquinone (CQ)/ ethyl 4-(dimethylamino)benzoate (EDAB) and CQ/EDAB/diphenyliodonium hexafluorophosphate (DPIHP); type I systems diphenyl(2,4,6-trimethylbenzoyl) phosphine oxide (TPO) and di-p-tolyl(2,4,6-trimethylbenzoyl) phosphine oxide (TMO). Polymerization kinetics were monitored by real-time spectroscopy, while post-cured resins and bonded interfaces were evaluated by cell viability, micro-tensile bonding strength (μTBS) and interfacial structural analyses.</p><p><strong>Results: </strong>Statistically significant polymerization retardation (one-way ANOVA) was observed when CMA was incorporated at low loadings (1 wt%) in resins with the type II systems CQ/EDAB and CQ/EDAB/DPIHP, whereas type I photoinitiators (TPO, TMO) maintained fast kinetics even at 5 wt% CMA loading. The enhanced kinetics associated with TPO and TMO correlated with improved cell viability. Generally, higher CMA loadings improved bonding strength and durability in both etch-and-rinse and self-etch systems, suggesting enhanced wet adhesion (two-way ANOVA). However, these improvements were not observed in self-etch type II systems, due to the significant polymerization retardation noted above.</p><p><strong>Significance: </strong>Catechol-induced inhibition is mitigated by optimizing the photoinitiator system, enabling the improvement of dentin bonding without sacrificing polymerization efficiency.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive performance of resin-modified glass ionomer cement functionalized with polyvalent metals and cyclic phosphates: Effects on demineralization resistance and mineralization-related cellular responses.","authors":"Marcelle Danelon, Rafael Antonio de Oliveira Ribeiro, Carlos Alberto de Souza Costa, Jörn Jaschinski, Torsten Sterzenbach, Christian Hannig","doi":"10.1016/j.dental.2026.08.013","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.013","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether functionalization of a resin-modified glass ionomer cement (RMGIC) with sodium trimetaphosphate (TMP) and stannous chloride (SnCl₂), individually or in combination, affects its resistance to demineralization, cytocompatibility, and mineralization-related cellular responses.</p><p><strong>Methods: </strong>Six experimental RMGIC formulations were prepared: (1) RMGIC; (2) RMGIC + 14% TMP; (3) RMGIC + 400 ppm SnCl₂; (4) RMGIC + 14%TMP + 400 ppm SnCl₂; (5) RMGIC + 800 ppm SnCl₂; and (6) RMGIC + 14%TMP + 800 ppm SnCl₂. The anti-demineralization effect was evaluated using a pH-cycling model by determining final surface hardness (fSH), percentage of surface hardness loss (%SHL), and integrated subsurface hardness loss (ΔKHN). Biological performance was assessed by cell viability, alkaline phosphatase (ALP) activity, and mineralized nodule formation.</p><p><strong>Results: </strong>The modified RMGIC formulation showed significantly improved anti-demineralization performance compared with the unmodified RMGIC. Formulations containing both additives exhibited higher final surface hardness and lower surface (%SHL) and subsurface (ΔKHN) mineral loss than the unmodified RMGIC (p < 0.05), whereas formulations containing TMP or SnCl₂ alone showed intermediate effects. None of the modifications adversely affected cell viability, with all formulations maintaining viability above 95%. In addition, the combined incorporation of TMP and SnCl₂ significantly increased ALP activity and mineralized nodule formation compared with the unmodified RMGIC (p ≤ 0.0001), indicating enhanced mineralization-related cellular responses.</p><p><strong>Clinical significance: </strong>Incorporation of TMP and SnCl₂ enhanced RMGIC resistance to demineralization while maintaining cytocompatibility and promoting mineralization-associated responses. This functionalization strategy supports the development of multifunctional restorative materials with improved mineral protection and biological activity beyond the properties of conventional glass ionomer cements.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic-reprogrammed MnO₂-Mg/Pt@BBF nanozyme disrupts biofilm cohesion for enhanced chemodynamic therapy of periodontitis.","authors":"Meng Bo, Jiao Fang, Yuning Wu, Zixuan Chen, Yingchi Liu, Shuang Liu, Chunyan Li, Lin Wang, Xiaolin Sun","doi":"10.1016/j.dental.2026.08.012","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.012","url":null,"abstract":"<p><strong>Objectives: </strong>To overcome the intrinsic incompatibility between dense periodontal biofilms and chemodynamic therapy (CDT), we developed a vacancy-engineered MnO₂ nanozyme that integrates redox-state programming, Mg²⁺-enabled endogenous H₂O₂ amplification, and covalently immobilized quorum-sensing inhibition for the local treatment of periodontitis.</p><p><strong>Methods: </strong>Mg²⁺-coordinated MnO₂ nanoflowers were decorated with Pt nanoparticles and covalently functionalized with BBF. Physicochemical properties, Mn valence states, H₂O₂ and ·OH generation, LuxS/AI-2 signaling, Porphyromonas gingivalis metabolomic changes, antibiofilm activity, and therapeutic efficacy in rat periodontitis were evaluated.</p><p><strong>Results: </strong>Pt decoration increased the Mn²⁺ fraction from 33% to 51%, while Mg²⁺ enhanced SpxB-mediated H₂O₂ production by Streptococcus gordonii. Immobilized BBF reduced AI-2 activity from 67.8% to 22.8% and downregulated luxS, fimA, mfa1, kgp, and rgpA. In dual-species biofilms, MnO₂-Mg/Pt@BBF yielded 68.7% dead cells, an approximately 4-log₁₀ reduction in viable bacteria, and the lowest residual thickness. Metabolomics revealed depletion of G6P, R5P, NADPH, ATP, and α-ketoglutarate in P. gingivalis. In vivo, treatment reduced periodontal bacterial burden by approximately 3 orders of magnitude and decreased the CEJ-ABC distance from 1.44 ± 0.28 mm to 0.56 ± 0.15 mm, accompanied by reduced inflammation and IL-6 expression, improved collagen organization, and elevated Arg-1 levels.</p><p><strong>Significance: </strong>This locally deliverable platform couples vacancy/valence-tuned catalysis, Mg²⁺-primed endogenous oxidant supply, and surface-immobilized quorum-sensing blockade, offering a composition-guided strategy for controlling polymicrobial periodontal biofilms and limiting infection-associated tissue destruction.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear bond strengths of primer-free and primer-based composite-cements to glass-ceramics and zirconia.","authors":"Felizitas von Knobloch, Christina Sykora, Thomas Obweger, Stefan Lettner, David C Watts, Andreas Schedle, Alexander Franz","doi":"10.1016/j.dental.2026.08.001","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.001","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to investigate the extent to which the bond strengths of composite-cements depend on (i) the adherend (zirconia versus glass-ceramics) and (ii) the usage of primers on the adherend prior to cementation.</p><p><strong>Methods: </strong>280 zirconia-specimens were sandblasted with aluminum oxide (110 μm/1 bar [AL 110/1] or 50 μm/0.5 bar [AL50/0.5]). 280 surface treated steel cylinders (Rocatec-Plus, Solventum at 3.5 bar; = 20 steel cylinders per cement) were bonded to the zirconia specimens with 3 primer-free (PanaviaSA, Kuraray [PSA]; Nexus-Universal, Kerr [NexU]; Maxcem-Elite, Kerr [MAX]) and 3 primer-based (require a primer) cements (RelyX-Universal, Solventum [RelyX]; PanaviaV5, Kuraray [PV5]; Calibra-Universal, Dentsply-Sirona [CalU]) each applied according to the manufacturers´ instructions. 140 lithium-disilicate glass-ceramic specimens (IPS e.max CAD Ivoclar [EMAX]) and 140 zirconia-reinforced lithium-silicate-glass-ceramic specimens (Vita Suprinity, Vita [VITA]) were bonded to surface-treated steel cylinders (see above, 20 steel cylinders per cement) using 2 primer-free (PanaviaSA, Kuraray [PSA]; Nexus-Universal, Kerr [NexU]) and 5 primer-based cements (RelyX-Universal, Solventum [RelyX]; Variolink-Esthetic-DC, Ivoclar [VarE]; Nexus3, Kerr [Nex3]; Panavia-V5, Kuraray [PV5]; Calibra-Universal, Dentsply-Sirona [CalU]) each according to the manufacturers´ instructions.</p><p><strong>Results: </strong>All failures were between ceramic and cement. The bond strengths of composite-cements were highest on VITA followed by ZIR50, EMAX and ZIR110 [p < 0.001]. Composite cements that required a primer and primer-free composite cements showed no significant difference in bond strength with ZIR50, EMAX and ZIR100; only for VITA the difference was significant [p < 0.001]. PanaviaSA had the highest bond strength on VITA, followed by RelyX-Universal and Nexus-Universal. On ZIR50 RelyX-Universal had the highest bond strength followed by Calibra-Universal and PanaviaSA. On EMAX the rank order was Calibra-Universal>PanaviaSA>RelyX-Universal, whereas on ZIR110 the rank order was RelyX-Universal>Calibra-Universal >PanaviaSA.</p><p><strong>Significance: </strong>The bond strengths of the investigated composite cements were significantly higher on the zirconia-reinforced-lithium-silicate glass-ceramic (VITA) than on the lithium-disilicate glass-ceramic (EMAX) and on zirconia. Primer-free composite cements showed similar or higher shear strengths than composite cements that required a primer (primer-based). The authors propose the implementation of more standardized experimental protocols when determining bond strengths, to enable the inter-study comparison of results in line with the suggestions offered by the Academy of Dental Materials.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of physicochemical, mechanical, and biological properties of biodegradable poly(lactic acid) (PLA) and commercial aligner materials.","authors":"Mayuri Parappullil Vellayappan, Sean Johnson, Taylor Stewart, Kristina Astleford-Hopper, Amy Tasca, Jae Sung Lee","doi":"10.1016/j.dental.2026.08.009","DOIUrl":"10.1016/j.dental.2026.08.009","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate bio-based, biodegradable polylactic acid (PLA) as a sustainable material for clear aligners by comparing its physicochemical, mechanical, and biological properties with commercial aligner materials (Essix Ace, Essix C+, Zendura FLX, and Zendura).</p><p><strong>Methods: </strong>PLA and commercial materials, both neat and aged in artificial saliva for up to 14 days, were examined as sheets. Thermal properties were measured using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Mechanical and optical properties were evaluated using a universal testing machine (UTM) and UV-visible spectrophotometry. Degradation behavior was assessed via weight and average molar mass changes, and surface morphology via scanning electron microscopy (SEM). Cytotoxicity was tested using human gingival fibroblasts with an MTT assay.</p><p><strong>Results: </strong>PLA showed a glass transition temperature of 55.4 °C, melting temperature of 152.1°C, and degradation onset temperature of 362.9 °C, comparable to commercial aligner materials. Its tensile strength and yield stress were similar to those of commercial materials, indicating adequate strength. However, PLA exhibited lower elongation at break and higher Young's modulus, reflecting higher brittleness and stiffness. Aging caused negligible water absorption, minimal weight loss, and minor thermal property change. Mechanical properties remained stable upon aging. Aged PLA was transparent when wet but became hazy when dry, which occurs reversibly. Extracts from PLA were non-cytotoxic, maintaining 90% cell viability in average.</p><p><strong>Significance: </strong>PLA demonstrated properties comparable to commercial aligner materials, with the exception of increased stiffness and brittleness. Its stability during aging and favorable biocompatibility supports its potential as a sustainable alternative for clear aligner applications.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical properties and clinical survival of bulk-fill composites: A systematic review with mAFR analysis.","authors":"Felizitas von Knobloch, Julius Selbertinger, Frank Pfefferkorn, David C Watts, Andreas Schedle","doi":"10.1016/j.dental.2026.07.004","DOIUrl":"https://doi.org/10.1016/j.dental.2026.07.004","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;The objectives of this study were to investigate the longevity and quality of restorations placed with bulk-fill composites compared to conventional composites. Both material categories were characterized by in-vitro properties (Part I) and by their longevity in short and long-term clinical studies (Part II).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;Part I: A systematic literature search was carried out for the period of 2010-2025 in PubMed, Embase, Web of Science und Scopus and structured according to the PRISMA flow diagram. Studies that examined the following mechanical properties of bulk-fill composites compared to conventional composites were included: Flexural strength according to the 3-point bending test, polymerization shrinkage according to ISO 17304 and shrinkage stress, using \"Bioman\" developed by D.C. Watts. In addition, the following inclusion criteria were applied: studies published in English or German, exclusively in-vitro studies, and use of standardized sample preparation for specific tests. Only studies with direct restorative materials and with at least one commercially available composite were included. Following the screening process, n = 88 studies were included. Data analysis was performed using weighted regression. The risk of bias in in-vitro dental material studies was assessed with the RoBDEMAT tool. Part II: Four different databases PubMed, MEDLINE via Ovid, Embase and Cochrane Library were used for a systematic literature retrieval of clinical trials between 2010 and 2025 regarding their longevity of bulk-fill composites in comparison to conventional composites, structured according to the PRISMA flow diagram. The inclusion criteria required that studies were reported in English, involved clinical trials with patients aged 18 and older and assessed only direct restorations examined according to World Dental Federation (FDI) and/or US Public Health Service (USPHS) methodology. Subsequently, n = 38 trials. were evaluated in terms of Esthetic, Functional and Biological properties and a calculation of the mean Annual Failure Rate (mAFR) was performed. Data analysis was performed using weighted regression. The Risk of bias tool for randomized trials (RoB 2) and the GRADE tool (Grading of Recommendations Assessment, Development, and Evaluatiodn) were also applied to enhance transparency in evaluating the evidence.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Part I: All bulk-fill composites had a flexural strength well above 80 MPa and can therefore be used in the posterior region including occlusal surface in accordance with ISO 4049. The polymerization shrinkage of 'Flowable base' bulk-fill materials (3.2%) was significantly lower than of conventional flowables (3.5%) and that of 'Full-body' bulk-fill composites (1.9%) was significantly lower than that of viscous universal composites (2.3%). The Flowable base bulk-fills achieved the significantly lowest shrinkage stress (2.4 MPa), followed by the Full-body bulk","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myricetin-loaded ZIF-8 improves dentin bonding durability via antibacterial activity, collagen stabilization and MMP inhibition.","authors":"Tianjia Huang, Huan Chen, Shuwei Qiao, Boyu Sun, Shuyao Zheng, Haiya Liao, Zuosen Shi, Song Zhu","doi":"10.1016/j.dental.2026.08.010","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.010","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to develop a myricetin-loaded ZIF-8 (Myr@ZIF-8)-modified universal adhesive with antibacterial, collagen-stabilizing, and matrix metalloproteinase (MMP)-inhibitory properties to improve bonding durability.</p><p><strong>Methods: </strong>Myr@ZIF-8 nanoparticles were synthesized and characterized. Myr loading efficiency, drug loading, and pH-responsive release were evaluated. Myr@ZIF-8 was incorporated into a universal adhesive at 2.5-10 wt%, and the optimal concentration was selected according to degree of conversion, dentin wettability, and antibiofilm activity. Dentin collagen stability, MMP-mediated gelatinolytic activity, microtensile bond strength (μTBS), interfacial nanoleakage, interfacial mechanical properties, and in vitro cytocompatibility were evaluated. Short-term systemic toxicity was preliminarily assessed by oral gavage of cured adhesive extracts. Molecular docking was performed to investigate potential interactions between myricetin and collagen, MMP-2, and MMP-9.</p><p><strong>Results: </strong>Myr@ZIF-8 exhibited a Myr loading efficiency of 50.72%, drug loading of 50.36%, and pH-responsive release. The adhesive containing 5 wt% Myr@ZIF-8 showed the best overall performance, including enhanced antibiofilm activity, improved collagen stability, and reduced MMP-mediated gelatinolytic activity. Incorporation of 5 wt% Myr@ZIF-8 increased immediate μTBS from 22.79 MPa to 32.07 MPa and aged μTBS after 10,000 thermocycles from 13.91 MPa to 27.99 MPa. Molecular docking predicted potential interactions between myricetin and collagen, MMP-2, and MMP-9. The modified adhesive showed acceptable in vitro cytocompatibility, with no obvious short-term systemic toxicity after oral gavage of cured adhesive extracts.</p><p><strong>Significance: </strong>These findings demonstrate that Myr@ZIF-8 functions as a multifunctional bioactive nanoplatform and represents a promising strategy for improving bonding durability.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Color-gradient lithium disilicate restorations fabricated via vat photopolymerization based on computer-assisted color matching.","authors":"Zengqi Ye, Xuanbing Chen, Xin Zhou, Qianshu Xia, Guangze Feng, Yangshuai Jin, Tianran Wang, Xian Tong, Zhaoping Chen, Yuncang Li, Li Zhu, Cuie Wen, Jixing Lin, Jianfeng Ma","doi":"10.1016/j.dental.2026.08.004","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.004","url":null,"abstract":"<p><strong>Objective: </strong>To fabricate personalized color-gradient dental lithium disilicate (LD) glass-ceramics by integrating computer-assisted color matching (CCM) with vat photopolymerization (VP).</p><p><strong>Methods: </strong>The particle size and elemental composition of zirconium silicate (ZrSiO₄)-based pigments were evaluated using laser diffraction and energy-dispersive X-ray spectroscopy analysis, respectively. 45 vol% resin-based slurries doped with Fe-Pr-V/ZrSiO₄ pigments were prepared. The rheological behavior and exposure parameters of monochromatic gradient-concentration slurries were analyzed using shear-rate sweep and working-curve methods. Diffuse-reflectance spectroscopy was used to establish a CCM database and evaluate the color-matching accuracy of LD based on the VITA 3D-Master shade guide. The sintering behavior of five LD ceramic shades (1M2-5M2) was evaluated using thermogravimetric analysis, differential scanning calorimetry and X-ray diffraction, and their densities were determined using porosity analysis. The mechanical properties of the five classical shades of LD ceramics were evaluated via flexural strength testing, Weibull modulus analysis, fracture-toughness testing, Vickers indentation, and nanoindentation. A color-gradient maxillary central incisor crown was fabricated and its 3D accuracy was evaluated.</p><p><strong>Results: </strong>Pigment particle sizes ranged from 5.9 to 8.9 μm with no interfacial defects in the LD matrix. Slurry viscosities at 50 °C were 2.3-2.5 Pa·s, while the red slurry required the highest exposure energy (12.2-16.7 mJ/cm²). Among the 26 predicted shades, 24 showed ΔE*ab < 3.7. After sintering, the relative density of the LD exceeded 99.5%. The LD specimens exhibited flexural strength of 380-428 MPa, fracture toughness of 2.94-3.50 MPa m¹ ᐟ², Weibull modulus > 10, Vickers hardness of 630-660 HV, and elastic modulus of 104-107 GPa. The color-gradient crown showed a root mean square deviation of 86.2 ± 5.7 μm.</p><p><strong>Significance: </strong>This study demonstrates the integration of CCM and VP to fabricate color-gradient LD restorations, providing a precise and personalized strategy for esthetic dental application.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical performance of CAD/CAM-fabricated lithium-disilicate-based glass ceramic vs. multilayer zirconia crowns after a minimum observation period of two years.","authors":"Tim Hausdörfer, Philipp Kanzow, Tina Rödig, Annette Wiegand, Clemens Lechte","doi":"10.1016/j.dental.2026.08.008","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.008","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate survival and success of ceramic crowns fabricated either of a lithium-disilicate-based glass ceramic or of a high translucent multilayer zirconia.</p><p><strong>Methods: </strong>Patients who received a computer-aided design/computer-aided manufacturing (CAD/CAM)-fabricated lithium-disilicate-based glass ceramic (CEREC Tessera, Dentsply Sirona) or high translucent multilayer zirconia (Katana Zirconia STML, Kuraray Noritace Inc.) crown were examined after a minimum observation time of 24 months. Two calibrated examiners assessed clinical performance of crowns using World Dental Federation (FDI) criteria. Survival and success rates were calculated using Kaplan-Meier method and statistically compared by log-rank test and Cox regression analysis. FDI criteria were compared by Mann-Whitney U tests (α=.05).</p><p><strong>Results: </strong>One-hundred restorations (n = 50 lithium-disilicate-based glass ceramic, n = 50 multilayer zirconia) placed in 63 participants were included. Multilayer zirconia crowns presented significantly (p < 0.01) higher survival (2-year-survival: 100%, mAFR: 0.0%) and success rates (2-year-success: 100%, mAFR: 0.0%) compared to restorations made from lithium-disilicate-based glass ceramic (2-year-survival: 82.0%, mAFR: 9.4%; 2-year-success: 82.0%, mAFR: 9.4%). Thirteen crowns made from lithium-disilicate-based glass ceramic (bulk fractures: n = 10, endodontic complication: n = 3) and 2 multilayer zirconia crowns failed (endodontic complication: n = 1, loose after loss of retention: n = 1). FDI criteria were not significantly different between both groups.</p><p><strong>Significance: </strong>Material selection is a critical determinant of the clinical performance of ceramic crowns. Short-time survival of lithium-disilicate-based glass ceramic was significantly lower compared with a high translucent multilayer zirconia.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}