Dental Materials最新文献

{"title":"Eco-friendly reinforcement of dental composites with poly(methyl methacrylate) and hydroxyapatite synthesized from eggshell waste.","authors":"Amine Yerou, Bel Abbes Bachir Bouiadjra, Omar Khatir, Mohamed Mokhtar Bouziane, Mohamed Elmeguenni, Mahmoud Khedr, Antti Järvenpää","doi":"10.1016/j.dental.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.dental.2025.10.002","url":null,"abstract":"<p><strong>Objectives: </strong>Hydroxyapatite (HAp), owing to its chemical similarity to enamel and bone, can enhance the bioactivity, biocompatibility, and antibacterial performance of poly(methyl methacrylate) (PMMA). This study aimed to develop and characterize a sustainable dental biocomposite by reinforcing PMMA with HAp synthesized from eggshell waste, with the objective of improving its mechanical and thermal performance while maintaining biocompatibility.</p><p><strong>Methods: </strong>HAp was synthesized from eggshells via wet chemical precipitation followed by calcination. The resulting powder was incorporated into PMMA at 10, 20, and 30 wt% fractions. Composites were evaluated using Fourier-Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), and Scanning Electron Microscopy (SEM). Mechanical properties were assessed under tensile and compressive loading.</p><p><strong>Results: </strong>The synthesized HAp exhibited high purity and crystallinity. The composite containing 10 wt% HAp demonstrated the most balanced performance, with higher glass transition temperature, enhanced thermal stability, and improved tensile and compressive strength compared to pure PMMA. SEM analysis confirmed more homogeneous dispersion at low filler concentrations, while higher loadings (20-30 wt%) led to agglomeration and reduced performance.</p><p><strong>Significance: </strong>Clinically, the optimized composite (10 wt% HAp) offers enhanced strength, durability, and thermal stability while maintaining biocompatibility, making it promising for dental prostheses, denture bases, and repair resins. This eco-friendly approach valorizes eggshell waste into a functional bioactive filler, supporting the advancement of sustainable dentistry.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrospun antibacterial β-Ag(VO₃)/PCL composite membranes for periodontal tissue regeneration.","authors":"André F P Lopes, Manuel F R P Alves, Inês Baptista, Tânia Caetano, Maria Helena F V Fernandes, Sandra I Vieira, Samuel Guieu","doi":"10.1016/j.dental.2025.09.018","DOIUrl":"https://doi.org/10.1016/j.dental.2025.09.018","url":null,"abstract":"<p><strong>Objective: </strong>Periodontitis is a widespread and challenging oral disease, which often involves recurring infections that complicate treatment. This study explores a novel tissue engineering approach to address such an issue, involving the design of a nanofibers-based composite material containing silver, a natural antibacterial agent.</p><p><strong>Methods: </strong>Pure β-Ag(VO₃) nanorods were synthesized via microwave irradiation and loaded into electrospun polycaprolactone (PCL) membranes. Integration was confirmed through FTIR, EDS, and XRD analyses and the release profile of Ag and V from the fibers was evaluated by ICP-OES. Biocompatibility towards mammalian cells recurred to resazurin metabolic, cell scoring and microscopy assays in cultured fibroblasts. Bioactivity against bacteria was evaluated in agar diffusion susceptibility tests using E. coli (Gram-negative) and S. aureus (Gram-positive).</p><p><strong>Results: </strong>A PCL-based electrospun membrane, loaded with β-Ag(VO₃) nanorods, was successfully developed and characterized. Incorporation of the nanorods improved the nanofibers' morphology, and the membranes showed a high cytocompatibility with fibroblasts. Importantly, a 0.5 % β-Ag(VO₃) concentration in the composite demonstrated antibacterial efficacy against Gram-negative and Gram-positive bacteria. This antibacterial effect is most likely due to a kill-on-contact mechanism rather than from the released of Ag ions, that was < 1 ppm over the 24 h of exposure.</p><p><strong>Significance: </strong>The ease of incorporating silver vanadates into polymeric membranes using the methodology here described, combined with the antibacterial effects and cytocompatibility presented by the composite membranes, suggests that these materials may represent a promising avenue for tackling recurring infections in the oral cavity and become valuable options in periodontitis treatment.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ceria-yttria pigmentation on the mechanical performance and esthetics of zirconia dental restorations.","authors":"Sivaranjani Gali, Akshay Arjun, Suhasini Gururaja","doi":"10.1016/j.dental.2025.09.014","DOIUrl":"https://doi.org/10.1016/j.dental.2025.09.014","url":null,"abstract":"<p><strong>Background: </strong>An optimum combination of esthetics and mechanical properties is expected of all-ceramic restorations. Consequently, various pigmentation techniques of zirconia have been recommended to enhance the aesthetic results without compromising their long-term survival.</p><p><strong>Methodology: </strong>Infiltrate solutions of ceria-yttria were prepared by mixing their precursors in various concentrations. Pre-sintered zirconia samples were soaked in the infiltrate solutions and sintered according to the manufacturer's instructions. Phase analysis, microstructure using scanning electron microscopy, flexural strength, fatigue, CIE Lab, translucency parameter, surface roughness, and aging resistance of infiltrated zirconia were evaluated.</p><p><strong>Results: </strong>Phase analysis confirmed the presence of the tetragonal phase of zirconia, and the microstructure revealed increased grain size. The flexural strength of infiltrated zirconia ranged from 248 MPa to 512 MPa, and the fatigue limit was lower than control zirconia with reduced surface roughness. The monoclinic content before and after aging was not detectable in the infiltrated samples. The CIE Lab values of the infiltrated samples showed a trend of decreasing lightness, accompanied by higher delta E values, with minimal change in translucency.</p><p><strong>Conclusions: </strong>Ceria-yttria infiltrated zirconia exhibited reasonable flexural strength and fatigue performance, with improved aging resistance, and color suitable for anterior and low-stress-bearing monolithic restorations.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoindentation-derived viscoelastic creep and ageing stability of heat-cured PMMA denture bases using a three-element Voigt model.","authors":"Sachin Varma, Smrithi Chandran, Mangalampalli Sr N Kiran, Payel Bandyopadhyay","doi":"10.1016/j.dental.2025.09.020","DOIUrl":"https://doi.org/10.1016/j.dental.2025.09.020","url":null,"abstract":"<p><p>The viscoelastic creep behaviour and long-term stability of heat-cured poly(methyl methacrylate) (PMMA) denture bases under clinically relevant processing conditions remain poorly characterised, necessitating the optimisation of fabrication protocols. In this study, twelve PMMA specimens (Sets A-C; 4 specimens per set, 25 indents/specimen) were prepared by varying curing pressure (500-2000 psi), time (30-180 min), or temperature (80-140°C). Nanoindentation creep tests (20 mN peak load; 10 s load, 20 s hold, 10 s unload; 10 Hz) recorded depth-time data, which were fitted to a three-element Voigt model (R² > 0.99) to extract instantaneous modulus (E₁^e), delayed modulus (E₂^e), and viscosity (μ). Statistical analyses (one-way ANOVA with Tukey HSD, α = 0.05) revealed that extending curing time from 30 to 180 nearly doubled E₁^e (2.15 ± 0.12-4.26 ± 0.15 GPa; p < 0.001) and increased μ by 332 % (30 ± 3-129 ± 8 GPa·s; p < 0.001), with optimal properties at 120°C (E₁^e = 4.72 ± 0.10 GPa; μ = 133.6 ± 7 GPa·s). Ageing for 12 months induced significant stiffening in under-cured samples (ΔE₁^e = +12 %; p < 0.05), but did not affect well-cured specimens. These results show that curing time and temperature critically govern PMMA's short‑term creep resistance and ageing behaviour, and that a 120°C × 60 min protocol maximises mechanical stability and durability, offering predictive insight for tailoring denture fabrication, although the increased risk of pore formation at this temperature must be considered.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue behavior and estimated lifetime of implant/abutments of different diameters.","authors":"Renan Brandenburg Dos Santos, Ulysses Lenz, Jason Alan Griggs, Alvaro Della Bona","doi":"10.1016/j.dental.2025.09.021","DOIUrl":"https://doi.org/10.1016/j.dental.2025.09.021","url":null,"abstract":"<p><strong>Objectives: </strong>Narrow-diameter (ND) implants may show distinct long-term mechanical behavior compared to standard-diameter (SD) implants when subjected to fatigue. This study evaluated the longevity of implant systems with different diameters by assessing structural damage and loosening after fatigue challenge.</p><p><strong>Methods: </strong>This in vitro study used sixty internal conical connection implants/abutments that were divided into two groups (n = 30) based on their diameters (3.0mm-ND and 4.0mm-SD). The manufacturer recommended torque was achieved for each abutment using a digital torque wrench. In order to determine damage and permanent displacement of abutments, cone beam computed tomography (CBCT) scans were post-processed (software e-Vol DX). The boundary fatigue method was adapted to use 2 × 10⁶ cycles, with frequency of 2 Hz, and constant peak load of 80 N for the first experiment. Load was adjusted (17.8 %) according to the failure rate for the second and third experiments. In addition to the aforementioned CBCT scans, removal torque values were used to assess torque loss. The probability of failure over time and the Weibull modulus were calculated for each group.</p><p><strong>Results: </strong>Loosening was observed in all ND specimens, regardless of the level of loading, and structural bending was observed in 6 abutments. In addition, 4 fractures occurred. No structural damage was observed for the SD specimens, and 6 of them did not suffer from loosening. The Weibull analysis showed a lower modulus (m) for SD (m=3.90; 95 %CI=2.75-5.54) than for ND (m=1.99; 95 %CI=1.50-2.64) resulting in lower probability of failure over time and slower decrease in removal torque for SD compared with ND specimens.</p><p><strong>Significance: </strong>The shorter predicted lifetime and faster torque loss of narrow-diameter implant/abutment suggest for a more frequent clinical follow-up of this treatment option.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of food-simulating liquids on the mechanical properties of lithium aluminosilicate glass-ceramics.","authors":"Hanan Al-Johani, Ashraf Al-Amoudi, Adolfo Di Fiore, Yu Zhang","doi":"10.1016/j.dental.2025.09.015","DOIUrl":"https://doi.org/10.1016/j.dental.2025.09.015","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the impact of simulated aging with food-simulating liquids (FSLs) on the Martens hardness, indentation depth, flexural strength, and reliability of lithium aluminosilicate glass-ceramics.</p><p><strong>Methods: </strong>Sixty square plates (12 ×12 ×1.5 mm) were prepared from a machinable fully crystallized lithium aluminosilicate glass-ceramic (Cerec Tessera, CT), then randomly allotted to four FSL groups: artificial saliva (CT-AS), citric acid (CT-CA), ethanol (CT-ET), or heptane (CT-HP). Martens hardness (HM) and indentation depth (ID) data were obtained using a hardness tester. Biaxial flexural strength (σ) was determined using the ball-on-three-balls apparatus in a universal testing machine. Weibull analysis was used to determine the characteristic strength (σ₀) and reliability (m̂_U). Data for HM and σ were analysed by one-way ANOVA, Tukey's HSD, and Pearson correlations (α = 0.05).</p><p><strong>Results: </strong>FSL type had a significant effect on HM (p < 0.001, η_p² = 0.889), ID (p < 0.001, η_p² = 0.879), and σ (p < 0.001, η_p² = 0.623). Minimal differences were observed between the effects of artificial saliva and heptane on HM (p = 0.914), whereas citric acid (p < 0.001) and ethanol (p = 0.001) showed significantly different effects. The highest σ₀ and m̂_U values were found in CT-AS (σ₀ = 319.26 MPa, m̂_U = 10.79), while the lowest were observed in CT-CA. A positive correlation was confirmed between HM and σ (p < 0.001, r = 0.731).</p><p><strong>Significance: </strong>Fully crystallized machinable lithium aluminosilicates exhibited adequate hardness and flexural strength after accelerated aging in artificial saliva; conversely, prolonged exposure to acidic FSLs jeopardized their mechanical properties.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical properties of vat photopolymerization additively manufactured zirconia monoliths and substrates for porcelain veneering: A pilot study.","authors":"Yue Zhu, Chenyuan Zhu, Jian Sun","doi":"10.1016/j.dental.2025.09.019","DOIUrl":"https://doi.org/10.1016/j.dental.2025.09.019","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the optical properties of additively manufactured zirconia monoliths and substrates for porcelain veneering and make a comparison with computer numerical control (CNC) milled zirconia.</p><p><strong>Methods: </strong>Stereolithography (SLA), digital light processing (DLP) and CNC milling technology were used to fabricate monolithic zirconia specimens with different thickness (Φ14.0 ×0.5/1.0 mm, n = 5). A2 feldspathic veneering ceramic (1.0 mm) was sintered to zirconia substrates (Φ14.0 ×0.5 mm) to prepare bilayered specimens (Φ14.0 ×1.5 mm, n = 5). Monolithic specimens underwent thermocycling between 5 ℃ and 55 ℃ up to 50000 cycles. A spectrophotometer was used to conduct color measurements before thermocycling and at every 10000 cycles. Translucency parameter (TP) of all specimens and color difference (ΔE) between bilayered specimens and A2 veneering ceramic were calculated. Data were analyzed by ANOVA and Tukey's post hoc tests (α=0.05).</p><p><strong>Results: </strong>The ANOVA revealed that material, thickness and thermocycles had significant influence on translucency(P＜0.001). Before and at each cycling interval, the TP of monolithic zirconia with different thickness ranking from highest to least were: CNC＞DLP＞SLA (P＜0.05). TP changed significantly at 30000 cycles for 0.5 mm-thickness SLA zirconia (P = 0.035), at 50000 cycles for 0.5 mm-thickness DLP zirconia (P = 0.036), 1.0mm-thickness SLA zirconia (P = 0.036) and 1.0 mm-thickness DLP zirconia (P = 0.017). ΔE between A2 veneer and SLA or DLP bilayered zirconia exceeded acceptability threshold (AT＞1.8).</p><p><strong>Significance: </strong>SLA and DLP monolithic zirconia had inferior translucency and color stability compared to CNC zirconia. A2 veneered bilayered SLA and DLP zirconia had a clinically unacceptable color difference with A2 shade.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas diffusion-mediated single-sided in situ gradient mineralized silk fibroin membrane for enhanced guided bone regeneration.","authors":"Zhao Li, Ying Kong, Qun Zhang, Jing Han, Kezheng Chen, Baojin Ma","doi":"10.1016/j.dental.2025.09.017","DOIUrl":"https://doi.org/10.1016/j.dental.2025.09.017","url":null,"abstract":"<p><p>Traditional guided bone regeneration (GBR) membranes face challenges in balancing mechanical strength, bioactivity, and osteoconductivity for effective periodontal bone regeneration. While collagen-based GBR membranes dominate clinical use, the weak mechanical properties and lack of osteoinductive capacity limit regeneration efficacy. Here, we presented a gas diffusion-mediated single-sided mineralization strategy to fabricate silk fibroin (SF)-based GBR membranes with dual barrier/osteoinductive functions. SF was dissolved in formic acid with Ca^2 + and, optionally, other bioactive metal ions (BMIs, such as Sr²⁺, Cu²⁺, or Mg²⁺), and a colloid was formed after the evaporation of formic acid. Followed by gradient mineralization under CO₂/NH₃ atmosphere and β-sheet induction via ethanol treatment, SF-Ca/X (X refers to other BMIs) membranes were prepared. Mineralized SF membranes featured a dense, mineral-free side for mechanical support and barrier, and an osteoinductive side by releasing BMIs. Interestingly, the calcium phosphate layer formed on the mineralized side, and the phase of CaCO₃ changed from calcite to vaterite, which helps phosphate mineralization. In vitro results demonstrated that the SF-Ca/Sr membrane enhanced osteogenic differentiation by upregulating BMP2/SMAD1 expression. In a rat mandibular defect model, the SF-Ca/Sr membrane significantly promotes new bone regeneration and collagen formation. Overall, this gas diffusion-mediated single-sided gradient mineralization approach integrates barrier properties with localized bioactivity, allowing for the required barrier/osteoinduction functions in the GBR process in one membrane.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting restoration failures in primary and permanent teeth - A machine learning approach.","authors":"Vitor Henrique Digmayer Romero, Eduardo Trota Chaves, Shankeeth Vinayahalingam, Helena Silveira Schuch, Xiongjie Chen, Yunpeng Li, Falk Schwendicke, Mariana Minatel Braga, Daniela Prócida Raggio, Cácia Signori, Raiza Dias Freitas, Fausto Medeiros Mendes, Marie-Charlotte Huysmans, Maximiliano Sérgio Cenci","doi":"10.1016/j.dental.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.dental.2025.09.009","url":null,"abstract":"<p><strong>Objective: </strong>Machine learning (ML) predictive models promise to handle complex data and deliver accurate predictions in the medical field. The aim of this study was to develop ML predictive models for posterior dental restorations failures in both primary and permanent teeth.</p><p><strong>Methods: </strong>Data from two clinical datasets were used in this study, encompassing a Randomized Controlled Trial (RCT) for permanent teeth (CaCIA Trial) and a corresponding RCT for primary teeth (CARDEC 3). Models were developed using five different algorithms-Decision Tree, Random Forest, XGBoost, CatBoost and Neural Network-ensuring thorough cross-validation and calibration for predictive reliability. Clinical variables related to patients and teeth were considered as predictors. Model performances were assessed using accuracy, precision, recall, F1-score and ROC AUC, alongside SHAP plots for interpretability.</p><p><strong>Results: </strong>In the primary teeth dataset, all models demonstrated acceptable performance with AUC values around 0.67-0.75 and a balanced trade-off between precision and recall. In contrast, the models applied to permanent teeth yielded less predictive ability, with AUC values ranging from 0.53 to 0.62.</p><p><strong>Conclusion: </strong>Our results highlight how ML approaches effectively process intricate, multi-dimensional data related to restoration longevity, successfully integrating variables across patient characteristics, tooth properties, and diagnostic assessments within a unified analytical framework. Though promising as analytical tools, clinical implementation requires further validation with expanded, heterogeneous datasets to improve robustness and accuracy.</p><p><strong>Clinical significance: </strong>Machine-learning models that predict the risk of posterior restoration failure-using routinely collected patient, tooth, and diagnostic data-may help dentists tailor recall intervals, prioritize preventive or reparative care, and allocate chair time more efficiently.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyacrylic acid/citrate/amorphous calcium phosphate complex for dentin remineralization and bond durability.","authors":"Yinying Chen, Xinyu Yang, Suqin Zhang, Hanjiao Wang, Haifeng Xie, Chen Chen","doi":"10.1016/j.dental.2025.09.016","DOIUrl":"https://doi.org/10.1016/j.dental.2025.09.016","url":null,"abstract":"<p><strong>Objective: </strong>Dentin bionic remineralization is an effective strategy for enhancing the stability of the resin-dentin bonding interface. Conventional biomimetic mineralization methods still face limitations such as restricted applicability and low mineralization efficiency. Citrate, present at high levels in biological mineralized tissues, plays a significant role in biomineralization. This study prepared polyacrylic acid/citrate/amorphous calcium phosphate complexes (PAA-Cit-ACP) and investigated its ability to promote biomimetic mineralization and improve the stability of the resin-dentin bonding interface.</p><p><strong>Methods: </strong>Four types of PAA-Cit-ACP complexes, each doped with different contents of citrate (PAA-Cit-ACP-0.5, PAA-Cit-ACP-1, PAA-Cit-ACP-2, and PAA-Cit-ACP-5), were synthesized and characterized. Molecular dynamics simulation was used to clarify the mechanism behind the formation of the PAA-Cit-ACP complexes. Single-layer recombinant collagen fibers and demineralized dentin slices were constructed as mineralization models to validate the mineralization potential of PAA-Cit-ACP. Nanoleakage and in situ zymography were used to evaluate the effect of PAA-Cit-ACP on the durability of resin dentin bonding.</p><p><strong>Results: </strong>Each group of PAA-Cit-ACP manifested as negatively charged, amorphous spherical nanoparticles with good biocompatibility. After treatment with PAA-Cit-ACP, both single-layer recombinant collagen fibers and demineralized dentin slices demonstrated rapid mineralization, and the resin-dentin bonding interface showed reduced nanoleakage and MMP activity, with PAA-Cit-ACP-1 and PAA-Cit-ACP-2 showing better effectiveness.</p><p><strong>Significance: </strong>These findings suggest that PAA-Cit-ACP promotes rapid biomimetic remineralization, protecting exposed demineralized collagen fibrils from water- and MMPs-induced degradation, and improving the stability of the hybrid layer.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}