Dental Materials最新文献

{"title":"The preventive effect of silver diamine fluoride-modified salivary pellicle on dental erosion.","authors":"Darren Dhananthat Chawhuaveang, Walter Yu Hang Lam, Chun Hung Chu, Ollie Yiru Yu","doi":"10.1016/j.dental.2024.10.014","DOIUrl":"10.1016/j.dental.2024.10.014","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the preventive effect of silver diamine fluoride (SDF) modified salivary pellicle (SP) against dental erosion.</p><p><strong>Methods: </strong>Enamel and dentin blocks allocated into 4 groups (n = 30 each). Blocks in Group SDF+SP were treated with SDF and SP. Blocks in Group SDF were treated with SDF. Blocks in Group DW+SP were treated with deionized water (DW) and SP. Blocks in Group DW were treated with DW. The blocks were subjected to an erosive challenge at pH 3.2 for 2 mins, 5 times per day for 14 days. Salivary pellicle morphology was assessed by atomic force microscopy (AFM). Crystal characteristics, percentage microhardness loss (%SMHL), surface loss, and surface morphology were assessed by X-ray diffraction (XRD), microhardness test, profilometry, and scanning electron microscopy (SEM), respectively.</p><p><strong>Results: </strong>AFM revealed a modified pellicle morphology in Group SDF+SP. XRD of both blocks revealed hydroxyapatite, silver chloride, silver phosphate, and silver fluoride in Groups SDF+SP and SDF. Fluoroapatite was found in Group SDF+SP only. %SMHL ( ± Standard deviation in %) of Groups SDF+SP, SDF, DW+SP, and DW were 33.4 ± 2.2, 38.6 ± 2.2, 50.3 ± 2.2, and 58.3 ± 2.4 in enamel and 16.1 ± 2.2, 19.7 ± 2.1, 32.8 ± 2.1, and 39.0 ± 2.3 in dentin, respectively. The presence of SDF and SP reduced %SMHL in both blocks (p < 0.001). The surface loss ( ± Standard deviation in μm) of Groups SDF+SP, SDF, DW+SP, and DW were 3.6 ± 0.7, 4.1 ± 0.4, 5.3 ± 0.5, and 7.0 ± 0.6 in enamel and 5.4 ± 0.6, 6.1 ± 0.5, 9.1 ± 0.7, and 9.2 ± 0.5 in dentin, respectively. The presence of SDF and SP reduced surface loss in enamel and dentin blocks (p = 0.031 and p = 0.002, respectively). SEM showed enamel surface remained relatively smooth and partially dentinal tubule occlusion on dentin blocks in Groups SDF+SP and SDF.</p><p><strong>Conclusion: </strong>SDF had a positively synergistic effect with SP. SDF-modified salivary pellicle provided a superior protective effect against dental erosion.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"58-69"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microspheres of stem cells from human exfoliated deciduous teeth exhibit superior pulp regeneration capacity.","authors":"Jianzhao Ding, Zheyi Sun, Liya Ma, Limeiting Wang, Zhenhui Liao, Lu Liang, Hefeng Yang, Rui Mao","doi":"10.1016/j.dental.2024.10.015","DOIUrl":"10.1016/j.dental.2024.10.015","url":null,"abstract":"<p><strong>Objectives: </strong>Engineering spheroids to create three-dimensional (3D) cell cultures has gained increasing attention in recent years due to their potential advantages over traditional two-dimensional (2D) tissue culture methods. Stem cells derived from human exfoliated deciduous teeth (SHEDs) demonstrate significant potential for pulpal regeneration applications. Nevertheless, the feasibility of microsphere formation of SHEDs and its impact on pulpal regeneration remain unclear.</p><p><strong>Methods: </strong>In this study, SHEDs were isolated, identified, and cultured in ultra-low attachment six-well plates to produce SHED microspheres. The biological properties of SHED microspheres were compared to those of traditional 2D culture using live-dead staining, Alizarin red staining, Oil-red O staining, scratch experiments, Immunofluorescence, Transmission electron microscopy scan, Western blotting, RNA sequencing, and a nude mice subcutaneous transplantation model.</p><p><strong>Results: </strong>We found SHED cells can form microspheres with a dense internal structure. SHED microspheres exhibited notable advantages over SHED cells in terms of biological properties, maintaining cell activity and enhancing cell differentiation, migration, and stemness in vitro. RNA-seq revealed that the SHED microspheres potentially influenced cell development, regulation of neurogenesis, skeletal system development, tissue morphogenesis singling pathway. In vivo, SHED microspheres promoted the generation of pulp tissue in dental pulp compared to traditional 2D culture.</p><p><strong>Conclusions: </strong>Microsphereization of SHED through 3D cell culture enhances its pulp regeneration capacity, presenting a novel strategy for dental pulp regeneration and the clinical treatment of dental pulp diseases.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"70-80"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical performance of endocrown restorations in anterior teeth: A systematic review and network meta-analysis.","authors":"Julia Fehrenbach, Jéssica Lopes Soares de Soares, João Carlos Silva do Nascimento Foly, Leonardo Lamberti Miotti, Eliseu Aldrighi Münchow","doi":"10.1016/j.dental.2024.10.012","DOIUrl":"10.1016/j.dental.2024.10.012","url":null,"abstract":"<p><strong>Objectives: </strong>To conduct a systematic review and network meta-analysis (NMA) to answer whether endocrown restorations have similar mechanical behavior than other traditional core-crown systems with or without intracanal posts for the rehabilitation of anterior endodontically treated teeth.</p><p><strong>Methods: </strong>The review followed the PRISMA Extension Statement for NMA. Studies were identified by a systematic search to select reports on endocrown restorations in anterior teeth. A search was performed in PubMed (MEDLINE), Scopus, Web of Science, Embase, SciELO, and LILACS databases. Articles evaluating mechanical performance through in vitro and finite element analysis (FEA) studies were selected and the risk of bias was assessed using the RoBDEMAT and ROBFEAD tools, respectively. The data were analyzed qualitatively and quantitatively through NMA using the MetaInsight tool.</p><p><strong>Results: </strong>Eleven articles were included (eight in vitro and three with FEA design). Six in vitro studies were evaluated using NMA. Composite resin endocrowns showed greater load-to-fracture and lower occurrence of catastrophic failures than traditional restorations. Combining glass fiber post with composite restoration also showed good strength behavior. Regarding FEA studies, two out of three studies showed a more homogeneous distribution of stress for the endocrown group.</p><p><strong>Significance: </strong>Endocrowns performed similarly to or better than conventional restorative strategies, with composite resin being the most recommended material of choice. The rehabilitation of endodontically treated anterior teeth with extensive coronal destruction is typically challenging for the dentist, and there is still no consensus in the literature that provides conclusive answers for choosing the appropriate material and restorative strategy. Exploring new techniques and materials that make this procedure easier for the dentist and guarantee good results is paramount.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"28-41"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital light printing of zirconia/resin composite material with biomimetic graded design for dental application.","authors":"Qiuyi Li, Yongzhe Liu, Delu Zhao, Yupu Yang, Qibo Liu, Yujun Zhang, Junling Wu, Zheqin Dong","doi":"10.1016/j.dental.2024.10.010","DOIUrl":"10.1016/j.dental.2024.10.010","url":null,"abstract":"<p><strong>Objective: </strong>Stress concentration and excessive wear on the opposite jaw teeth are the main problems that lead to the failure of all-ceramic crown restoration. The objectives of this study were to: (1) Synthesize the biomimetic gradient zirconia/resin composites. (2) Control the porosity and structure so that the mechanical properties of the biomimetic gradient zirconia/resin composites are close to enamel and dentin.</p><p><strong>Methods: </strong>Biomimetic uniform zirconia scaffolds with different widths (1.6 mm, 1.8 mm, 1.9 mm, 2.0 mm, 2.2 mm) and Biomimetic gradient (1.6 mm-2.2 mm) zirconia scaffolds were designed using 3DMax and Magics, fabricated by digital light processing 3D printing, and then infiltrated into dental resin for mechanical testing, finite element simulation and cytotoxicity testing.</p><p><strong>Results: </strong>Results show that the ceramic-polymer composites exhibit a significant enhancement in strength (1.37-fold increase) and toughness (2.08-fold increase) compared to zirconia ceramic scaffold (P < 0.05), highlighting the effectiveness of our structural design. In addition, the gradient design further improves the mechanical strength of the composites. Notably, the gradient composite crown exhibits a bending strength of 138.3 (±16.7) MPa, a toughness of 9.0 (±0.5) MJ/m³, and a compressive strength of 113.7 (±2.6) MPa, values that are comparable to those of natural enamel and dentin, and shows good biosafety.</p><p><strong>Conclusion: </strong>Biomimetic gradient zirconia/dental resin materials were precisely fabricated through a series of studies, which is expected to further improve the clinical treatment effect. At the same time, the strategic design also provides new ideas for the performance improvement of other dental materials.</p><p><strong>Significance: </strong>Gradient zirconia/resin composite materials with mechanical properties matching natural teeth were precisely fabricated, and are expected to significantly improve clinical treatment outcomes. Additionally, the strategic design provides new insights for enhancing the performance of other dental materials.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"16-27"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene nanocoating on titanium maintains structural and antibiofilm properties post-sterilization.","authors":"Julien Luc Paul Morin, Nileshkumar Dubey, Emma Kim Luong-Van, Baiqing Yu, Clarice Ferreira Sabino, Nick Silikas, Shruti Vidhawan Agarwalla, Ah Castro Neto, Vinicius Rosa","doi":"10.1016/j.dental.2024.10.009","DOIUrl":"10.1016/j.dental.2024.10.009","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of sterilization methods on the structural integrity and antimicrobial properties of graphene nanocoating on titanium (GN).</p><p><strong>Methods: </strong>GN was transferred to titanium using wet (WT) or dry transfer (DT) techniques and sterilized using an autoclave (AC), glutaraldehyde (GA), or ethylene oxide (EtO). The GN structure was characterized using Raman spectroscopy before and after sterilization. Additional specimens were characterized by Raman after AC and water jetting. Biofilm formation was assessed before and after AC using colony-forming units (CFU), biofilm biomass, and SEM (uncoated titanium was the control). Three independent samples were used for structural characterization and biofilm quantification. Statistical analyses were conducted using one-way analysis of variance (ANOVA) and Tukey's test (α = 0.05).</p><p><strong>Results: </strong>WT and DT demonstrated high structural stability after sterilization and water jetting, with negligible coating quality or coverage loss. GN exhibited lower biofilm formation even after AC sterilization, as shown by the reduction in CFU counts, biofilm biomass, and SEM images compared to the control.</p><p><strong>Significance: </strong>GN demonstrated high resistance to the stresses imposed by all sterilization methods tested, maintaining its structural integrity, resistance to water-jet cleaning, and antibiofilm potential. The findings suggest that standard industrial practices can effectively sterilize highly resilient GN on titanium implants and possibly other biomaterials.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"7-15"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How many tooth colors are there?","authors":"Sascha Hein, Ján Morovič, Peter Morovič, Omnia Saleh, Jörg Lüchtenborg, Stephen Westland","doi":"10.1016/j.dental.2024.10.016","DOIUrl":"10.1016/j.dental.2024.10.016","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to estimate the number of distinct tooth colors using a large dataset of in-vivo CIELAB measurements. It further assessed the coverage error (CE) and coverage error percentage (CEP) of commonly used shade guides and determined the number of shades needed for an ideal guide, using the Euclidean distance (ΔEab) and thresholds for clinical perceptibility (PT) and acceptability (AT) as evaluation criteria.</p><p><strong>Methods: </strong>A total of 8153 untreated maxillary and mandibular anterior teeth were measured in vivo using calibrated dental photography. Cardinality was applied to determine the number of unique natural tooth colors. The CE and CEP were calculated for the Vita Classical and Vita 3D-Master shade guides, while the cardinality method was also used to estimate the number of shades required to adequately cover the estimated gamut of natural tooth colors.</p><p><strong>Results: </strong>The cardinality analysis revealed 1173 unique natural tooth colors. The CE for the Vita Classical shade guide was 4.1 ΔEab, with a CEP of 75 % beyond AT, while the 3D-Master shade guide had a CE of 3.3 ΔEab and a CEP of 70 % beyond AT. Based on cardinality computation, 92 discrete shades are required to adequately cover the estimated gamut of natural tooth colors with a CE of 1.2 ΔEab and CEP of 0.3 % beyond AT.</p><p><strong>Conclusions: </strong>Cardinality computations estimated 1173 unique tooth colors while 92 discrete shades are estimated for full coverage. Such a number is impractical for physical shade guides, but new digital tools and 3D printing may offer future solutions. Both, the Vita Classical and 3D-Master shade guides do not fully represent the range of natural tooth colors.</p><p><strong>Clinical significance: </strong>This study highlights the limitations of existing shade guides and underscores the potential for new developments.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"51-57"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ability of a novel primer to enhance the polymerization of a self-cured resin composite.","authors":"Juliana Anany Gonzales Guarneri, Cristiane Maucoski, Soheil Ghaffari, Brett Daniel MacNeil, Richard Bengt Price, Cesar Augusto Galvão Arrais","doi":"10.1016/j.dental.2024.10.013","DOIUrl":"10.1016/j.dental.2024.10.013","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the degree of conversion (DC), polymerization kinetics, and temperature of a new self-cure bulk-fill resin-based composite (Stela Automix, SDI).</p><p><strong>Methods: </strong>The study was divided into seven groups: (1) Stela Primer, (2) Stela Automix, (3) Stela Automix exposed to light for 20 s after 100 s, (4) Stela Primer with Stela Automix, (5) Stela Primer with Stela Automix and exposed to light for 20 s after 100 s, (6) Scotchbond Universal with Stela Automix, and (7) Scotchbond Universal with Stela Automix and exposed to light for 20 s after 100 s. The real-time reaction rates and DC at the bottom of 2 mm thick specimens at ∼32 °C were measured at 720 s after insertion using a spectrometer with an Attenuated Total Reflectance detector. The temperature of Stela, Stela exposed to light, Stela Primer with Stela, and Stela Primer with Stela exposed to light were measured by an infrared thermal camera in human molar teeth with Class I cavities. The temperature was recorded in real-time every 0.03 s for 720 s. The results were compared with ANOVA and Tukey's multiple comparison test (α = 0.05).</p><p><strong>Results: </strong>The highest degree of conversion (DC) at the 2 mm depth was achieved when Stela Primer was combined with Stela (72.4 ± 3.5 % at 720 s). Stela could self-cure independently, but not as rapidly or effectively as when used with its Primer. The greatest temperature increase was for the light-cured Stela, followed by Stela Primer with Stela RBC exposed to light for 20 s. The Scotchbond Universal bonding system did not significantly increase the DC compared to Stela alone, except when exposed to light for 20 s, which slightly increased the final DC. Exposing Stela to light for 20 s did not improve the final DC of Stela as much as using the Stela Primer, but it did increase the temperature and prolonged the time taken to return to 37 °C.</p><p><strong>Significance: </strong>The Stela primer accelerates the degree of conversion of Stela. The reaction occurred rapidly and achieved a higher DC at the bottom of the specimens where the Stela was in contact with the Stela primer. Exposing Stela to light for 20 s is not recommended. Instead, Stela should be used with Stela Primer.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"42-50"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of 10-MDP and GPDM monomers on viability and inflammatory response in human dental pulp stem cells.","authors":"Fabiana Dubau Cavallaro-Mota, Gabriela Nunes Esposo, Matheus Kury, Bruna M Fronza, Cintia Helena C Saraceni, Denise Carleto Andia, Adriano F Lima","doi":"10.1016/j.dental.2024.10.008","DOIUrl":"10.1016/j.dental.2024.10.008","url":null,"abstract":"<p><strong>Objectives: </strong>to assess the cytotoxicity of the following functional monomers used in dental adhesives: 10-Methacryloyloxydecyl dihydrogen phosphate (10-MDP) and glycerol phosphate dimethacrylate (GPDM), and their effect on cytokine release from human dental pulp stem cells (hDPSCs).</p><p><strong>Methods: </strong>The hDPSCs cells were isolated from the dental pulp of extracted human third molars. The functional monomers, 10-MDP and GPDM, were diluted in dimethyl sulfoxide (DMSO) at concentrations ranging from 1 to 4 mM. Cells not exposed to the compounds served as controls. The hDPSCs were seeded into 96-well plates and incubated for 48 h. Subsequently, the cells were exposed to 10-MDP and GPDM for 24 h. Then, the culture medium was removed, the mitochondrial metabolism was evaluated using the MTT assay, while cell death analyzed by flow cytometry. Cytokine release (IL-1β, IL-6, IL-8, IL-10, TNF-α) was analyzed by the MAGPIX. The data were analyzed using one-way ANOVA and Tukey's test.</p><p><strong>Results: </strong>10-MDP demonstrated significant toxicity to hDPSCs, reaching the IC50 at 3 mM. However, its impact on cytokine release was minimal, resulting only in IL-6 and IL-8 levels. GPDM exhibited lower toxicity, even at 4 mM, but induced an increase in IL-1β release and a reduction in IL-6, IL-8, and IL-10 levels, with no effect on TNF-α. Despite the MTT assay results indicating cytotoxicity, the cell death was low for both functional monomers.</p><p><strong>Significance: </strong>10-MDP exhibited significant toxicity to hDPSCs, unlike GPDM, however, both monomers resulted in minimal cell death. 10-MDP had a minor impact on cytokine release, whereas GPDM demonstrated a potential to trigger an inflammatory reaction, particularly in the short term.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"1-6"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"Novel co-initiators of polymerization: Cytotoxicity profile and modulation of inflammatory mediators in human dental pulp stem cells\" [Dent Mater 40/10 (2024) 1692-1696].","authors":"Adriano F Lima, Giulia G Pizzanelli, Camila S Stolf, Jean-Pierre Salomon, Jacques Lalevée, Denise Carleto Andia","doi":"10.1016/j.dental.2024.11.001","DOIUrl":"10.1016/j.dental.2024.11.001","url":null,"abstract":"","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"100"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification and bibliometric analysis of hydrogels in periodontitis treatment: Trends, mechanisms, advantages, and future research directions.","authors":"Reena Das, Nisha Suryawanshi, Nishant Burnase, Anand Barapatre, Rajathirajan Siva Dharshini, Bikash Kumar, Pachaiyappan Saravana Kumar","doi":"10.1016/j.dental.2024.10.017","DOIUrl":"10.1016/j.dental.2024.10.017","url":null,"abstract":"<p><strong>Objectives: </strong>The review assess the potential of hydrogel-based drug delivery systems in treating periodontitis. Hydrogels are classified based on source, composition, configuration, crosslinking methods, ionic charge, and response to stimuli.</p><p><strong>Methods: </strong>The methodology comprised of comprehensive data collection from WoS, Scopus and PubMed databases covering the period of 2004-2024 of 626 documents. A bibliometric analysis was conducted using VOS Viewer to identify research trends, key contributors, prominent topics, and leading journals. A comparative analysis was performed to examine the benefits of hydrogels over conventional periodontitis treatments. Current research and innovations in hydrogel formulations were reviewed, including ongoing clinical trials and commercial products.</p><p><strong>Results: </strong>China was found to be the leading contributor to hydrogel research in periodontitis, with key topics including \"hydrogels,\" \"nanoparticles,\" and \"drug delivery.\" A detailed classification system for hydrogels was established, aiding in their application for targeted drug delivery and tissue regeneration. Hydrogels were found to offer controlled drug release, support for tissue regeneration, and improved clinical outcomes compared to traditional treatments. Innovations highlighted including the use of various polymers like nano-hydroxyapatite/collagen composites, PLGA-based materials, and chitosan gels in clinical trials, demonstrating enhanced cell proliferation and tissue regeneration.</p><p><strong>Significance: </strong>This review underscores the significant potential of hydrogel-based therapies in advancing the treatment of periodontitis. By providing a comprehensive bibliometric analysis and highlighting key research and innovations, it emphasizes the advantages of hydrogels in terms of targeted drug delivery, minimal invasiveness, and support for tissue regeneration. The findings suggest that with further clinical trials and regulatory approvals, hydrogels could become a mainstream, effective treatment option for periodontitis, offering improved patient outcomes and potentially transforming periodontal therapy.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":"81-99"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}