Dental Materials最新文献

{"title":"Guidance for evaluating biomaterials' properties and biological potential for dental pulp tissue engineering and regeneration research.","authors":"Vinicius Rosa, Bruno Neves Cavalcanti, Jacques E Nör, Arzu Tezvergil-Mutluay, Nikolaos Silikas, Marco C Bottino, Anil Kishen, Diana Gabriela Soares, Cristiane M Franca, Paul Roy Cooper, Henry F Duncan, Jack L Ferracane, David C Watts","doi":"10.1016/j.dental.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.dental.2024.12.003","url":null,"abstract":"<p><strong>Background: </strong>Dental pulp regeneration is a complex and advancing field that requires biomaterials capable of supporting the pulp's diverse functions, including immune defense, sensory perception, vascularization, and reparative dentinogenesis. Regeneration involves orchestrating the formation of soft connective tissues, neurons, blood vessels, and mineralized structures, necessitating materials with tailored biological and mechanical properties. Numerous biomaterials have entered clinical practice, while others are being developed for tissue engineering applications. The composition and a broad range of material properties, such as surface characteristics, degradation rate, and mechanical strength, significantly influence cellular behavior and tissue outcomes. This underscores the importance of employing robust evaluation methods and ensuring precise and comprehensive reporting of findings to advance research and clinical translation.</p><p><strong>Aims: </strong>This article aims to present the biological foundations of dental pulp tissue engineering alongside potential testing methodologies and their advantages and limitations. It provides guidance for developing research protocols to evaluate the properties of biomaterials and their influences on cell and tissue behavior, supporting progress toward effective dental pulp regeneration strategies.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial coatings for dental implants: A systematic review.","authors":"Marta Teulé-Trull, Pablo Altuna, María Arregui, Xavier Rodriguez-Ciurana, Conrado Aparicio","doi":"10.1016/j.dental.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.dental.2024.12.001","url":null,"abstract":"<p><strong>Objectives: </strong>Despite the high survival rates of dental implants, peri-implantitis is a prevalent complication. Peri-implantitis is related to biofilm that adheres to the surface of implants and causes peri-implant chronic inflammation and bone destruction. Different surface treatments have been proposed to prevent biofilm formation. The objective of this systematic review was analyzing different types of antimicrobial coatings and identifying the most effective one(s) to control bacterial colonization over extended periods of analysis.</p><p><strong>Data, sources and study selection: </strong>We performed a bibliographic search in Pubmed and Cochrane base of articles published after 2010 to answer, according to the PICO system, the following question: What is the most effective antibacterial surface coating for dental implants? Only papers including a minimum follow-up bacteria growth analysis for at least 48 h were selected. After selection, the studies were classified using the PRISMA system. A total of 40 studies were included.</p><p><strong>Conclusions: </strong>Three main categories of coatings were identified: Antibacterial peptides, synthetic antimicrobial molecules (polymers, antibiotics, …), and metallic nanoparticles (silver). Antibacterial peptide coatings to modify dental implant surfaces have been the most studied and effective surface modification to control bacterial colonization over extended periods of incubation as they are highly potent, durable and biocompatible. However, more in vitro and pre-clinical studies are needed to assess their true potential as a technology for preventing peri-implant infections.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of photoinitiator systems on resin-based composite containing ZnO-nanoparticles.","authors":"Abdulaziz Alayed, Nikolaos Silikas, David C Watts","doi":"10.1016/j.dental.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.dental.2024.12.002","url":null,"abstract":"<p><strong>Objective: </strong>Zinc oxide (ZnO) powder possesses antibacterial activity and although white in color, it can severely reduce the depth of cure (DoC) of resin-based composite (RBC). This study investigated the effect of unary and binary photoinitiator systems on the DoC and degree of conversion (DC) of formulated RBC containing ZnO-nanoparticles.</p><p><strong>Methods: </strong>Fourteen RBCs (n = 3/group) were formulated consisting of 50 wt% mixture of monomers (Bis-GMA, TEGDMA, and UDMA) and 50 wt% fillers (inert barium glass powder and silica nanoparticles). ZnO-nanoparticles were added at 0 (control), 0.5, 1, 1.5 and 2 wt%. A unary initiator system consists of camphorquinone (CQ) 0.25, 0.5 and 1 wt% and ethyl 4-(dimethylamino)benzoate (EDMAB) 0.75 wt% or a binary initiator system consisting of diphenyliodonium hexafluorophosphate (DPI) 0.25, 0.5 and 1 wt%, CQ 0.25, 0.5 and 1 wt% and EDMAB 0.75 wt% were added to the monomer mixture. To measure the DoC, each specimen was prepared in a custom-made mold with a slot (16 x 8×2 mm) and a top cover plate, irradiated from one end (40 s), stored dry (37° C, 1 d) and measured at increasing depths using Vickers hardness (0.5 mm intervals). 1 mm thick specimens were prepared to measure DC continuously using FTIR, from zero up to 24 h post-irradiation.</p><p><strong>Results: </strong>Increasing the concentrations of ZnO led to a significant reduction of DoC (p < 0.05). But most of the binary initiator groups showed significantly higher DoC (p < 0.05). Depth, at 80 % of max VHN, of unary initiator groups reduced from 6.8 mm (ZnO at 0 wt%) to 2.1 mm (ZnO at 2 wt%) and in binary initiator groups from 8.4 mm to 2.3 mm. Groups with lower photoinitiator concentrations (0.25 wt%) showed a significant increase in DoC compared with groups with higher concentrations (1 wt%) (p < 0.05). DC after 24 h was independent of either ZnO concentration or the photoinitiator system (p > 0.05). However, faster conversions were observed in binary initiator groups. The RP_max of binary groups ranged from 8.1 % to 10.1 %/s, and unary groups ranged from 5.2 % to 7.2 %/s.</p><p><strong>Significance: </strong>The addition of DPI resulted in an overall increased curing depth, which was enhanced when lower concentrations of photoinitiators were used. Also, DPI resulted in faster conversions. This is desirable in designing antibacterial RBC containing ZnO.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cement layer thickness and load-bearing capacity of tooth restored with lithium-disilicate glass ceramic and hybrid ceramic occlusal veneers.","authors":"Topias Yli-Urpo, Lippo Lassila, Timo Närhi, Pekka Vallittu","doi":"10.1016/j.dental.2024.11.004","DOIUrl":"https://doi.org/10.1016/j.dental.2024.11.004","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the influence of cement layer and veneer thickness on load-bearing capacity of tooth restored with hybrid ceramic (HC) and lithium-disilicate glass ceramic (LDGC) occlusal veneer restorations.</p><p><strong>Methods: </strong>Cement layer thickness was set at either 50 µm or 200 µm and tooth restored either with 0.5 mm or 1.8 mm thick HC Cerasmart270 (GC) or LDGC IPS e.max CAD (Ivoclar Vivadent) occlusal veneers. For this study, 64 extracted human molar teeth were selected and divided into 8 groups. Prepared teeth were scanned, and occlusal veneers were manufactured using CAD/CAM technology (Cerec, Dentsply-Sirona). Finished veneers were luted to preparations using self-adhesive resin cement (G-CEM ONE) according to manufacturers' instructions. Teeth were loaded quasi-statically and ultimate fracture loads were recorded. Fracture types were analyzed and classified visually. Statistical analysis was performed using two-way ANOVA.</p><p><strong>Results: </strong>With HC occlusal veneers, thickness of both veneer and cement layer had no significant influence on fracture load. The lowest mean ultimate fracture load value was found in 0.5 mm thick LDGC veneers group with 200 µm cement layer, which was significantly lower loading value compared with that of 1.8 mm thick LDGC veneers or any of HC veneers (p ≤ 0.0280). LDGC veneers with 0.5 mm thickness showed fractures within the veneer, whereas in other groups fractures of the tooth substance was also detected.</p><p><strong>Conclusions: </strong>Within the limitations of this study, it can be concluded that thin HC occlusal veneers provided higher load-bearing capacity than LDGC counterparts of the same thickness. HC veneers were also less sensitive to the effect of cement layer thickness.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is galvanic corrosion between implant abutments and roots a possible scenario? An experimental study under simulated healthy and inflammatory peri-implant conditions and F anions.","authors":"Spiros Zinelis, Georgios Polychronis, Spiridon Silvestros, Andreas Barbetseas, Dimitris Karasoulos, George Eliades","doi":"10.1016/j.dental.2024.11.009","DOIUrl":"https://doi.org/10.1016/j.dental.2024.11.009","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effect of healthy and inflammatory conditions and the presence of F anions on the galvanic coupling between the root surface and titanium abutments of commercially available titanium implants MATERIALS AND METHODS: Eight pairs of three dental root-abutment couples (BEGO, MIS, NOBEL) were exposed to a neutral (pH=7.4) (HE) and an acidic (pH=4.0) (IN) phosphate buffer solution (PBS) simulating healthy and inflammatory conditions respectively. In order to simulate the presence of F anions, which is commonly used in toothpastes, 3.12 gr of NaF was added in both solutions simulating healthy conditions (HEF) and inflammatoy conditions (INF) with the presence of F anions respectively. The galvanic potential difference was recorded for 48 h and averaged. Physical appearance of abutment and roots were tested under a stereomicroscope. Scanning electron microscopy and X-ray energy dispersive spectroscopy (SEM/EDX) was used to characterize the materials under reseach and compare the surfaces before and after galvanic testing.</p><p><strong>Results: </strong>All abutments are composed of Ti-6Al-4V alloy along with root of MIS system, while BEG and NOB are made of Ti according to the SEM/EDX analysis. No differences were identified in surface morphology before and after galvanic testing, while EDX analysis revealed only the presence of Na and F on the surface of MIS abutments after testing in INF conditions. All groups tested showed negligible potential difference and below the nominal threshold for triggering galvanic corrosion under HE, IN and HEF conditions. The same applies for BEG and MIS under INF conditions, while NOB presented an average potential difference value of -273 mV, which is above nominal thresshold for galvanic action. Only MIS abutment showed a color change from yellow to blue under INF conditions.</p><p><strong>Conclusions and clinical implications: </strong>BEG and MIS implant systems are not prone to galvanic corrosion in all conditions tested. NOB was found vulnerable to galvanic corrosion under inflammatory peri-implant conditions in the presence of F anions. Galvanic reactions is a possible scenario even between Ti base implant components.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-step sintering suppresses grain growth and improves flexural strength of dental zirconia.","authors":"Chek Hai Lim, Larissa M M Alves, Sonaj Vardhaman, Estevam A Bonfante, Do Kyung Kim, Yu Zhang","doi":"10.1016/j.dental.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.dental.2024.11.008","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to elucidate the effect of various two-step sintering (TSS) protocols on the physical, mechanical, and optical properties of partially stabilized zirconia with different yttria dopant concentrations (Y-PSZ).</p><p><strong>Methods: </strong>Disc-shaped specimens were obtained from most widely used commercial dental zirconia powders of various Y contents (Tosoh Corp.) by uniaxial pressing followed by cold-isostatic pressing. Densification was carried out using TSS protocols with varying temperatures for both sintering steps. Relative density (ρ_Rel), microstructure, and phase content were analyzed. Biaxial flexural strength (σ) and translucency parameter (TP) were evaluated.</p><p><strong>Results: </strong>The TSS results were compared with optimized conventional sintering (CS) results from a previous study for the same Y-PSZ compositions. TSS 3Y-PSZ and 4Y-PSZ reached similar ρ_Rel to those of their CS counterparts, whereas 5Y-PSZ failed to achieve that regardless of TSS protocol. TSS yielded less cubic phase compared to CS, especially for 3Y-PSZ and for higher temperatures. TSS suppressed the grain growth throughout the temperature range investigated, promoting smaller grains than CS (p < 0.05). The TP values for TSS Y-PSZ were lower than those of CS (p ≤ 0.0001), except for 3Y-PSZ. The σ values for TSS Y-PSZ were significantly higher than those of CS (p ≤ 0.0002).</p><p><strong>Significance: </strong>TSS increased strength without significantly jeopardizing the optical properties of various Y-PSZ compositions relative to their CS counterparts. This alternative sintering method appears to be a promising technique for controlling grain growth while eliminating porosities in dental Y-PSZ ceramics, thus potentially enhancing the clinical longevity of zirconia restorations.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of TiF4-Dendrimer complex gel as an anti-demineralization agent for dentin: An in vitro study.","authors":"Taraneh Estedlal, Ladan Ranjbar Omrani, Khosrou Abdi, Niyousha Rafeie, Zohreh Moradi","doi":"10.1016/j.dental.2024.11.007","DOIUrl":"https://doi.org/10.1016/j.dental.2024.11.007","url":null,"abstract":"<p><strong>Objective: </strong>The anti-caries effects of titanium tetrafluoride (TiF4) are well-documented, but its low pH challenges clinical application. This study evaluated PEG-citrate dendrimer as a carrier to enhance TiF4 stability and efficacy.</p><p><strong>Methods: </strong>PEG-citrate dendrimer and TiF4-dendrimer gel were synthesized, and their structures confirmed using Fourier Transform Infrared Spectroscopy (FTIR), Hydrogen Nuclear Magnetic Resonance (1H NMR), and Liquid Chromatography-Mass Spectrometry (LC-MS). Thirty-six intact human teeth were prepared, randomly divided into three groups (n = 12) and subjected to pH cycling with the following treatments: titanium tetrafluoride (T), dendrimer (D), and dendrimer with TiF4 (TD). Vickers microhardness and Raman spectroscopy evaluated dentin demineralization. EDS analysis measured titanium and fluoride penetration into dentin in T and TD groups and mineral content (calcium and phosphorus) in all groups.</p><p><strong>Results: </strong>The T group showed the highest microhardness loss (p < 0.001), followed by D and TD groups. EDS analysis revealed no significant difference in titanium and fluoride content between the surface and subsurface in TD (p = 0.344), while T had more titanium on the surface (p < 0.001). TD had higher subsurface calcium content compared to T (p = 0.008). Raman spectroscopy revealed significant changes in phosphate-to-amide and carbonate-to-amide ratios before and after pH cycling in all groups (p < 0.001), with no statistical differences among the groups.</p><p><strong>Conclusion: </strong>Using dendrimer as a carrier for TiF4 increased pH and enhanced TiF44 ability to limit dentin demineralization and microhardness loss.</p><p><strong>Clinical relevance: </strong>The application of the newly-developed TiF4-dendrimer gel might be an effective approach to prevent/ limit dentin demineralization and dentin caries.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution of adhesive dentistry: From etch-and-rinse to universal bonding systems.","authors":"Lorenzo Breschi, Tatjana Maravic, Claudia Mazzitelli, Uros Josic, Edoardo Mancuso, Milena Cadenaro, Carmem S Pfeifer, Annalisa Mazzoni","doi":"10.1016/j.dental.2024.11.011","DOIUrl":"https://doi.org/10.1016/j.dental.2024.11.011","url":null,"abstract":"<p><strong>Objectives: </strong>This review aimed at presenting the mechanisms and pitfalls of adhesion to enamel and dentin, advances in the materials science and in the development of strategies to improve hybrid layer (HL) longevity.</p><p><strong>Methods: </strong>Search of the literature was performed on PubMed, Scopus and Web of Science with keywords related to the structure of the dental substrate, HL degradation mechanisms and strategies to contrast them.</p><p><strong>Results: </strong>Albeit the advances in the dental materials' properties, HL degradation is still a relevant and current issue in adhesive dentistry. However, adhesive materials have become more resistant and less operator sensitive, and good adhesion is currently in the hands of every practitioner. Numerous novel strategies are being developed, able to improve the resistance of adhesive resins to degradation, their ability to infiltrate and chemically bond to dentin, to remove the unbound/residual water within the HL, reinforce the dentin collagen matrix, and inhibit endogenous metalloproteinases. Many of the strategies have turned to nature in search for powerful biomodifying compounds, and for the inspiration as to mimic naturally occurring regenerative processes.</p><p><strong>Significance: </strong>Extensive knowledge on the structure of the dental substrate and the complexity of adhesion to dentin has led to the development of improved formulations of dental adhesives and numerous valid strategies to improve the strength and longevity of the HL. Nevertheless, for many of them the road from bench to chairside still seems long. We encourage practitioners to know their materials well and use the strategies readily available to them.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofabrication - Revolutionizing the future of regenerative periodontics.","authors":"Isaac J de Souza Araújo, Marco C Bottino","doi":"10.1016/j.dental.2024.11.006","DOIUrl":"https://doi.org/10.1016/j.dental.2024.11.006","url":null,"abstract":"<p><p>Periodontium is a compartmentalized and highly specialized tissue responsible for tooth stability. Loss of tooth attachment due to periodontitis and trauma is a complex clinical burden affecting a large parcel of the adult and elderly population worldwide, and regenerative strategies to reestablish the native conditions of the periodontium are paramount. Biofabrication of scaffolds, through various techniques and materials, for regenerative periodontics has significantly evolved in the last decades. From the basics of occlusive membranes and graft materials to the complexity of converging 3D printing and Bioprinting using image-based models, biofabrication opens many possibilities for patient-specific scaffolds that recapitulate the anatomical and physiological conditions of periodontal tissues and interfaces. Thus, this review presents fundamental concepts related to the native characteristics of the periodontal tissues, the key to designing personalized strategies, and the latest trends of biofabrication in regenerative periodontics with a critical overview of how these emerging technologies have the potential to shift the one-size-fits-all paradigm.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of dental resin composites with anti-bacterial adhesion against Streptococcus mutans using fluorinated and silicon containing dimethacrylates.","authors":"Shengcan Zhang, Xinlin He, Fang Liu, Xiangya Huang, Sui Mai, Jingwei He","doi":"10.1016/j.dental.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.dental.2024.11.010","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to enhance the anti-bacterial adhesion effect against Streptococcus mutans (S. mutans) of fluorinated dimethacrylate (DF MA) based dental resin composites (DRCs) by using silicone dimethacrylate (SMA-MEO).</p><p><strong>Method: </strong>The SMA-MEO was added into mixture of DFMA and tricyclo (5.2.1.0) decanedimethanol diacrylate (SR833s) (DFMA/SR833s = 50 wt./50 wt.) with mass ratios of 10 wt% and 20 wt% to form resin matrix both with fluorinated and silicon containing dimethacrylates, and then DRCs named DS+ 10 %SMA-MEO and DS+ 20 %SMA-MEO were prepared by mixing the resin matrix with silaned BaAlSiO₂ filler particles at a mass ratio of 30 wt./70 wt. Double bond conversion, volumetric shrinkage and shrinkage stress, flexural strength and modulus, water sorption and solubility, contact angle and surface free energy, anti-bacterial adhesion effect against Streptococcus mutans (S. mutans), and cytotoxicity of prepared DRCs were investigated according to standard or referenced methods. Fluorinated dimethacrylate (DFMA) based DRC named DS and 2,2-bis[4-(2-hydroxy-3-methacryloy-loxypropyl)-phenyl]propane (Bis-GMA) based DRC named BT were used as controls.</p><p><strong>Results: </strong>Adding SMA-MEO into DFMA based DRC could lead to higher double bond conversion (p < 0.05), higher hydrophobicity (p < 0.05), and lower surface free energy (p < 0.05). Only DS+ 10 %SMA-MEO had better anti-bacterial adhesion effect against S. mutans than DS (p < 0.05). The SMA-MEO had no influence on volumetric shrinkage, shrinkage stress, flexural modulus, water sorption and solubility of DRC (p > 0.05), but could reduce flexural strength of dry DRC (p < 0.05). After water immersion, SMA-MEO containing DRCs had comparable flexural strength as DS (p > 0.05). Compared with BT, DS and SMA-MEO containing DRCs had better or comparable physicochemical properties, and lower amount of adherent S. mutans. All of DRCs had comparable cytotoxicity (p > 0.05).</p><p><strong>Significance: </strong>DRCs with both DFMA and SMA-MEO could have better anti-bacterial adhesion effect against S. mutans than DRC only with DFMA due to increased hydrophobicity and decreased Surface free energy, and the optimal mass fraction of SMA-MEO in DFMA based resin matrix was 10 wt%.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}