Dental Materials最新文献

{"title":"Spheroidized powder enables the fabrication of highly translucent dental lithium disilicate glass-ceramics via 3D printing and controlled thermal processing.","authors":"Yunlong Zhang, Nan Li, Guangliang Niu, Hezhen Li, Jianmin Han","doi":"10.1016/j.dental.2026.08.014","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.014","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the effects of heat treatment on the morphology of lithium disilicate glass-ceramic (LDGC) powder, as well as the influence of sintering conditions on the microstructure, mechanical properties, and translucency of LDGCs produced via 3D printing. Furthermore, the in vitro cytocompatibility of the specimens was assessed.</p><p><strong>Methods: </strong>The optimal powder was selected from different spheroidized groups and used to prepare vat photopolymerizable slurry. The printed green bodies underwent a single-step debinding-sintering process, and specimens sintered at different temperatures were evaluated for mechanical and optical properties. The group exhibiting the best overall properties was further assessed for in vitro cytocompatibility.</p><p><strong>Results: </strong>The spheroidized powder, characterized by a bimodal particle size distribution, exhibited excellent flowability at a solid loading of 50 vol%. Under optimal sintering conditions, the specimens attained a relative density of 99.6% and high translucency, with a light transmittance of 46.90 ± 0.51% at 550 nm, alongside a CIEDE2000 translucency parameter of 12.63 ± 0.26, comparable to IPS e.max CAD HT A2. The measured biaxial flexural strength, Vickers hardness, and fracture toughness were 274.98 ± 35.35 MPa, 642.31 ± 8.74 HV, and 2.72 ± 0.08 MPa·m¹ ᐟ², respectively. Moreover, the specimens exhibited favorable in vitro cytocompatibility. These findings support the clinical application potential of printed LDGCs.</p><p><strong>Significance: </strong>A novel approach for fabricating highly translucent LDGC restorations via vat photopolymerization was developed, showing promise as a fabrication strategy for anterior aesthetic restorations.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gingival temperature rise and tissue injury associated with diode laser-based versus LED curing protocols in a swine model.","authors":"Vinicius Borges Oliveira, Juliana Guarneri, Lucas Arrais Campos, Thiago Martins, Camila Falconi-Páez, Cristiane Maucoski, Leandro Cavalcante Lipinski, Cesar Augusto Galvão Arrais","doi":"10.1016/j.dental.2026.09.005","DOIUrl":"https://doi.org/10.1016/j.dental.2026.09.005","url":null,"abstract":"<p><strong>Objectives: </strong>To measure in vivo gingival temperature rise (ΔT), peak temperature, and the incidence and probability of lesions in swine gingiva exposed to diode laser- and LED-based light-curing protocols. The protective effect of rubber dam isolation (RDI) was also assessed.</p><p><strong>Methods: </strong>After Ethics Committee approval (23.000010496-0), 100 pigs were subjected to general anesthesia. In 50 pigs, a thermocouple probe (Thermes WFI, Physitemp) was inserted into the gingival sulcus to measure temperature (°C) before and after exposure to light from a conventional LED (EDC - Elipar DeepCure, Solventum) and a high-power ultrafast diode laser (ML - Monet, AMD Laser). Exposure protocols with different radiant exposure values were applied (EDC-5s, EDC-10s, EDC-20s; ML-1s, ML-3s), with or without RDI (n = 10). Gingival lesion incidence was assessed in the remaining animals. ΔT data were analyzed using nonparametric two-way ANOVA with Bonferroni post-hoc test. Logistic regression estimated odds ratios (95% confidence intervals) (α = 0.05).</p><p><strong>Results: </strong>EDC-20s showed the highest ΔT values. ML-1s produced ΔT comparable to EDC-5s, whereas ML-3s did not differ from EDC-20s. RDI reduced ΔT in most groups. Lesion incidence was below 45% in most groups. Despite similar ΔT, ML-3s showed the highest lesion incidence and was the only protocol associated with severe lesions due to high radiant exposure over a confined area. Logistic regression showed no significant effect for EDC, whereas ML-3s significantly increased lesion probability.</p><p><strong>Significance: </strong>Ultrafast laser protocols produced ΔT comparable to LED but increased the risk of severe gingival lesions. Damage was more closely associated with radiant exposure than with exposure time or average temperature increase.</p><p><strong>Clinical relevance: </strong>Ultrafast laser-based protocols produced gingival temperature increases comparable to those observed with conventional LED curing. Localized energy delivery appears to play a critical role in thermal injury, highlighting the importance of considering radiant exposure and beam characteristics when using high-power light-curing devices near soft tissues.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particle characterization of different air-abrasion techniques and their impact on dentin topography and bonding performance of a universal adhesive.","authors":"Romina Ñaupari-Villasante, Diego Melendez, Michel Wendlinger, Leandro Augusto Hilgert, Rui Falacho, Filipe J Oliveira, João Carlos Ramos, Alessandro D Loguercio","doi":"10.1016/j.dental.2026.08.016","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.016","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of different air-abrasion protocols on dentin surface properties and bonding performance of a universal adhesive applied with etch-and-rinse (ER) or self-etch (SE) strategies.</p><p><strong>Methods: </strong>One hundred and twenty-six human molars were allocated according to airborne-particle abrasion protocols: control (no air-abrasion), dry abrasion (25 µm and 50 µm Al₂O₃), moist abrasion (29 µm and 53 µm Al₂O₃), and moist bioglass. Particles were characterized by SEM, FTIR and size distribution. Before bonding, dentin surfaces were characterized by FTIR-ATR, 3D profilometry, and SEM (tubule density and smear layer thickness). Bonding performance was assessed by micro-Raman spectroscopy of hybrid layers (immediate), nanoleakage, and microtensile bond strength (µTBS), immediate and after thermocycling (n = 8). Data were analyzed using ANOVA and post hoc tests (α = 0.05).</p><p><strong>Results: </strong>Dry air-abrasion produced fewer chemical alterations and lower smear layer deposition (p < 0.05), whereas moist abrasion increased mineral loss and smear layer persistence (p < 0.05). Surface roughness increased after Al₂O₃ abrasion, while bioglass resulted in smoother surfaces (p < 0.05). The ER strategy promoted higher dentinal tubule exposure than SE (p < 0.05). Dry Al₂O₃ abrasion, particularly 50 μm with ER, showed the highest immediate μTBS, lower nanoleakage, and more stable bonding after thermocycling (p < 0.05). In contrast, moist-abrasion protocols, especially bioglass, reduced μTBS and increased nanoleakage (p < 0.05).</p><p><strong>Significance: </strong>Dry air-abrasion with 50 µm aluminum oxide improves immediate dentin bonding over moist protocols, particularly with ER strategy. No pretreatment enhances bonding after thermocycling compared to air-abraded dentin.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and evaluation of a ternary thiol-yne-dimethacrylate dental resin composite exhibiting low stress and high mechanical performance.","authors":"Huilin Deng, Shanmei Zeng, Jingwei He","doi":"10.1016/j.dental.2026.09.003","DOIUrl":"https://doi.org/10.1016/j.dental.2026.09.003","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to comparatively evaluate whether the incorporation of multifunctional thiol‑ene or thiol‑yne resin systems into conventional dimethacrylate‑based DRCs offers greater advantages in achieving both low polymerization shrinkage stress and high mechanical strength. The first hypothesis was that increasing the thiol‑ene and thiol‑yne content would promote the interaction between dimethacrylates and the thiol‑ene or thiol‑yne reaction pathways, thereby reducing polymerization shrinkage stress while maintaining adequate mechanical properties. The second hypothesis was that dimethacrylate‑based DRCs incorporating thiol‑yne components would exhibit superior overall mechanical properties compared to those containing thiol‑ene components.</p><p><strong>Methods: </strong>Polymerization kinetics and methacrylate double bond conversion were quantified using Fourier-transform infrared spectroscopy (FTIR). Dynamic mechanical analysis (DMA) was used to determine dynamic mechanical properties. The mechanical properties of the cured DRCs were comprehensively assessed through three-point bending tests, compression tests, diametral tensile tests, Vickers microhardness, and fracture toughness tests. Shrinkage stress during DRC curing was monitored in real-time using a universal testing machine's stress sensor. Finally, the biocompatibility of the DRCs was verified using the CCK8 assay.</p><p><strong>Results: </strong>The results indicated that incorporating thiol-ene or thiol-yne mixtures as resin components into conventional dimethacrylate resins synergistically combined the excellent mechanical properties of dimethacrylates with the reduced shrinkage stress advantage of thiol-ene/yne systems via improved polymerization kinetics through step-growth polymerization. Among these systems, ternary thiol-yne-dimethacrylate DRCs outperformed ternary thiol-ene-dimethacrylate DRCs in terms of mechanical properties due to a more highly crosslinked network formed by the thiol-yne components. At high thiol-yne content, ternary thiol-yne-dimethacrylate DRCs exhibited a 50.3-75.3% reduction in shrinkage stress compared to conventional dimethacrylate DRCs, while maintaining adequate mechanical properties. Additionally, the flexural strength of the DRCs improved by 22.5-37.1%.</p><p><strong>Significance: </strong>The ternary thiol-yne-dimethacrylate DRCs developed in this study hold the potential to significantly reduce polymerization shrinkage stress, enhance mechanical strength and other fundamental properties of DRCs, leading to superior dental restorative materials.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the effect of a photocurable bioadhesive composite hydrogel for dentin caries management.","authors":"Xizhe Chen, Rui Yuan, Jiayu Zhang, Weichang Li, Qinghui Zhi","doi":"10.1016/j.dental.2026.09.002","DOIUrl":"https://doi.org/10.1016/j.dental.2026.09.002","url":null,"abstract":"<p><strong>Objective: </strong>Conventional invasive restorations for dental caries often leads to healthy tissue loss. This study developed a photocurable composite bioadhesive hydrogel (GelMA-QAS/DMA@HAP) as a minimal invasive surface coating for the management of caries through synergistic antibacterial and remineralization pathways.</p><p><strong>Methods: </strong>Gelatin methacryloyl (GelMA) was functionalized with a C8 alkyl quaternary ammonium salt (QAS) for antibacterial activity and methacryloyl dopamine (DMA, 5 mg/mL) for wet adhesion, followed by the incorporation of 5% (w/v) nano-hydroxyapatite (nHAP). Adhesive performance was evaluated via shear bond strength testing in accordance with ISO/TS 11405. Antibacterial activity against Streptococcus mutans UA159 was assessed using plate counting for planktonic bacteria and live/dead staining coupled with confocal laser scanning microscopy for mature biofilms (n = 3). In vitro tubule occlusion was observed on acid-etched bovine dentin (n = 3). In vivo remineralization was evaluated using a 7-day rat demineralized dentin defect model (n = 5/group), with Vickers microhardness as the primary outcome. Statistical analyses utilized ANOVA or non-parametric equivalents with a significance threshold of p < 0.05.</p><p><strong>Results: </strong>FTIR and ¹H NMR confirmed successful synthesis. The hydrogel formulation containing 5 mg/mL DMA exhibited the highest shear bond strength among tested groups (p < 0.05). Sustained release of calcium and phosphate ions was maintained over 120 h. The hydrogel significantly inhibited planktonic S. mutans growth (p < 0.01) and reduced the proportion of viable bacteria in mature biofilms to approximately 10% after 24 h of incubation (p < 0.05). In vitro, the hydrogel effectively penetrated and formed mineral plugs within exposed dentinal tubules. In vivo, the Vickers microhardness of treated demineralized defects increased to approximately 30 HV0.01, significantly higher than that of untreated controls (<20 HV0.01) (p < 0.05).</p><p><strong>Significance: </strong>The GelMA-QAS/DMA@HAP hydrogel integrates wet-surface adhesion, contact-active antibacterial properties, and mineral deposition into a single photocurable system. While current evidence is limited to preclinical in vitro assessments and short-term in vivo defect models, this material demonstrates potential as an adjunctive coating strategy for the minimal invasive preservation and management of caries.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A chlorinated mussel-inspired monomer stabilizes dentin via anti-proteolysis and collagen cross-linking.","authors":"Na Ouyang, Canwen Zhang, Leqi Yang, Haoyu Jiang, Yu Zhang, Kang Li","doi":"10.1016/j.dental.2026.08.015","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.015","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether the novel monomer N-(2-chloro-4,5-dihydroxyphenethyl) methacrylamide (Cl-DMA) provides dual anti-proteolytic and collagen cross-linking effects on demineralized dentin matrices.</p><p><strong>Methods: </strong>A 10% ethanol/water solution served as the vehicle control, and Cl-DMA solutions were prepared at concentrations of 1, 10, and 100 mM. A 10 mM chlorhexidine acetate (CHX) solution and a 10 mM glutaraldehyde (GA) solution served as positive controls for anti-proteolytic and cross-linking effects, respectively. Inhibitory effects on matrix metalloproteinases (MMP-2, -8, -9) and Clostridium histolyticum collagenase were assessed using enzyme activity kits. In situ zymography with confocal laser scanning microscopy (CLSM) quantified MMP activity at the bonding interface. Demineralized human dentin beams treated with these solutions for 1 h were evaluated for dry mass loss, hydroxyproline release, and swelling ratio. Collagen fibril ultrastructure was observed via FESEM, while Cl-DMA/collagen binding characteristics were analyzed using ATR-FTIR spectroscopy. Molecular docking simulated the binding modes of Cl-DMA and CHX with MMPs.</p><p><strong>Results: </strong>Cl-DMA inhibited protease activity in a generally concentration-dependent manner. While 10 mM Cl-DMA exhibited weaker inhibition of soluble MMPs than CHX, in situ zymography revealed that 10 and 100 mM Cl-DMA significantly inhibited interfacial MMP activity, comparable to CHX. Furthermore, 100 mM Cl-DMA significantly reduced dry mass loss, hydroxyproline release, and swelling ratio. FESEM indicated decreased porosity and increased compactness of the collagen network with higher Cl-DMA concentrations. FTIR confirmed non-covalent hydrogen bond cross-linking without triple-helix disruption. Molecular docking results demonstrated that Cl-DMA could bind to MMP-2, -8, and -9, though with weaker binding affinities than CHX.</p><p><strong>Significance: </strong>Cl-DMA effectively inhibited protease activity and promoted collagen cross-linking and stabilization. The 100 mM concentration exhibited the greatest overall efficacy under the present experimental conditions, supporting the potential of Cl-DMA as a multifunctional dentin pretreatment agent for reducing enzymatic degradation of demineralized dentin collagen.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing dentin bonding with catechol-based monomers by tailoring photoinitiator systems to overcome radical inhibition.","authors":"Denghao Fu, Surbhi Punhani-Schillinger, Romina Esmaeilzade, Caroline Szczepanski","doi":"10.1016/j.dental.2026.08.011","DOIUrl":"10.1016/j.dental.2026.08.011","url":null,"abstract":"<p><strong>Objective: </strong>Although catechol-functionalized polymers show promise for improving adhesion in wet environments, these catechol groups also inhibit free-radical polymerization, slowing kinetics, reducing conversion, increasing cytotoxicity, and compromising bonding performance. This study evaluates alternative photoinitiator systems to overcome catechol-induced inhibition in both etch-and-rinse and self-etch adhesives.</p><p><strong>Methods: </strong>Catechol methacrylamide (CMA) was incorporated into a methacrylate-based adhesive resin (0 to 5 wt%) as a partial replacement for the traditionally employed monomer 2-hydroxyethyl methacrylate (HEMA). The photopolymerization behavior of CMA-modified adhesives were investigated with varying photo-initiating systems, including type II photoinitiator systems camphorquinone (CQ)/ ethyl 4-(dimethylamino)benzoate (EDAB) and CQ/EDAB/diphenyliodonium hexafluorophosphate (DPIHP); type I systems diphenyl(2,4,6-trimethylbenzoyl) phosphine oxide (TPO) and di-p-tolyl(2,4,6-trimethylbenzoyl) phosphine oxide (TMO). Polymerization kinetics were monitored by real-time spectroscopy, while post-cured resins and bonded interfaces were evaluated by cell viability, micro-tensile bonding strength (μTBS) and interfacial structural analyses.</p><p><strong>Results: </strong>Statistically significant polymerization retardation (one-way ANOVA) was observed when CMA was incorporated at low loadings (1 wt%) in resins with the type II systems CQ/EDAB and CQ/EDAB/DPIHP, whereas type I photoinitiators (TPO, TMO) maintained fast kinetics even at 5 wt% CMA loading. The enhanced kinetics associated with TPO and TMO correlated with improved cell viability. Generally, higher CMA loadings improved bonding strength and durability in both etch-and-rinse and self-etch systems, suggesting enhanced wet adhesion (two-way ANOVA). However, these improvements were not observed in self-etch type II systems, due to the significant polymerization retardation noted above.</p><p><strong>Significance: </strong>Catechol-induced inhibition is mitigated by optimizing the photoinitiator system, enabling the improvement of dentin bonding without sacrificing polymerization efficiency.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13558896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive performance of resin-modified glass ionomer cement functionalized with polyvalent metals and cyclic phosphates: Effects on demineralization resistance and mineralization-related cellular responses.","authors":"Marcelle Danelon, Rafael Antonio de Oliveira Ribeiro, Carlos Alberto de Souza Costa, Jörn Jaschinski, Torsten Sterzenbach, Christian Hannig","doi":"10.1016/j.dental.2026.08.013","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.013","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether functionalization of a resin-modified glass ionomer cement (RMGIC) with sodium trimetaphosphate (TMP) and stannous chloride (SnCl₂), individually or in combination, affects its resistance to demineralization, cytocompatibility, and mineralization-related cellular responses.</p><p><strong>Methods: </strong>Six experimental RMGIC formulations were prepared: (1) RMGIC; (2) RMGIC + 14% TMP; (3) RMGIC + 400 ppm SnCl₂; (4) RMGIC + 14%TMP + 400 ppm SnCl₂; (5) RMGIC + 800 ppm SnCl₂; and (6) RMGIC + 14%TMP + 800 ppm SnCl₂. The anti-demineralization effect was evaluated using a pH-cycling model by determining final surface hardness (fSH), percentage of surface hardness loss (%SHL), and integrated subsurface hardness loss (ΔKHN). Biological performance was assessed by cell viability, alkaline phosphatase (ALP) activity, and mineralized nodule formation.</p><p><strong>Results: </strong>The modified RMGIC formulation showed significantly improved anti-demineralization performance compared with the unmodified RMGIC. Formulations containing both additives exhibited higher final surface hardness and lower surface (%SHL) and subsurface (ΔKHN) mineral loss than the unmodified RMGIC (p < 0.05), whereas formulations containing TMP or SnCl₂ alone showed intermediate effects. None of the modifications adversely affected cell viability, with all formulations maintaining viability above 95%. In addition, the combined incorporation of TMP and SnCl₂ significantly increased ALP activity and mineralized nodule formation compared with the unmodified RMGIC (p ≤ 0.0001), indicating enhanced mineralization-related cellular responses.</p><p><strong>Clinical significance: </strong>Incorporation of TMP and SnCl₂ enhanced RMGIC resistance to demineralization while maintaining cytocompatibility and promoting mineralization-associated responses. This functionalization strategy supports the development of multifunctional restorative materials with improved mineral protection and biological activity beyond the properties of conventional glass ionomer cements.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic-reprogrammed MnO₂-Mg/Pt@BBF nanozyme disrupts biofilm cohesion for enhanced chemodynamic therapy of periodontitis.","authors":"Meng Bo, Jiao Fang, Yuning Wu, Zixuan Chen, Yingchi Liu, Shuang Liu, Chunyan Li, Lin Wang, Xiaolin Sun","doi":"10.1016/j.dental.2026.08.012","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.012","url":null,"abstract":"<p><strong>Objectives: </strong>To overcome the intrinsic incompatibility between dense periodontal biofilms and chemodynamic therapy (CDT), we developed a vacancy-engineered MnO₂ nanozyme that integrates redox-state programming, Mg²⁺-enabled endogenous H₂O₂ amplification, and covalently immobilized quorum-sensing inhibition for the local treatment of periodontitis.</p><p><strong>Methods: </strong>Mg²⁺-coordinated MnO₂ nanoflowers were decorated with Pt nanoparticles and covalently functionalized with BBF. Physicochemical properties, Mn valence states, H₂O₂ and ·OH generation, LuxS/AI-2 signaling, Porphyromonas gingivalis metabolomic changes, antibiofilm activity, and therapeutic efficacy in rat periodontitis were evaluated.</p><p><strong>Results: </strong>Pt decoration increased the Mn²⁺ fraction from 33% to 51%, while Mg²⁺ enhanced SpxB-mediated H₂O₂ production by Streptococcus gordonii. Immobilized BBF reduced AI-2 activity from 67.8% to 22.8% and downregulated luxS, fimA, mfa1, kgp, and rgpA. In dual-species biofilms, MnO₂-Mg/Pt@BBF yielded 68.7% dead cells, an approximately 4-log₁₀ reduction in viable bacteria, and the lowest residual thickness. Metabolomics revealed depletion of G6P, R5P, NADPH, ATP, and α-ketoglutarate in P. gingivalis. In vivo, treatment reduced periodontal bacterial burden by approximately 3 orders of magnitude and decreased the CEJ-ABC distance from 1.44 ± 0.28 mm to 0.56 ± 0.15 mm, accompanied by reduced inflammation and IL-6 expression, improved collagen organization, and elevated Arg-1 levels.</p><p><strong>Significance: </strong>This locally deliverable platform couples vacancy/valence-tuned catalysis, Mg²⁺-primed endogenous oxidant supply, and surface-immobilized quorum-sensing blockade, offering a composition-guided strategy for controlling polymicrobial periodontal biofilms and limiting infection-associated tissue destruction.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear bond strengths of primer-free and primer-based composite-cements to glass-ceramics and zirconia.","authors":"Felizitas von Knobloch, Christina Sykora, Thomas Obweger, Stefan Lettner, David C Watts, Andreas Schedle, Alexander Franz","doi":"10.1016/j.dental.2026.08.001","DOIUrl":"https://doi.org/10.1016/j.dental.2026.08.001","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to investigate the extent to which the bond strengths of composite-cements depend on (i) the adherend (zirconia versus glass-ceramics) and (ii) the usage of primers on the adherend prior to cementation.</p><p><strong>Methods: </strong>280 zirconia-specimens were sandblasted with aluminum oxide (110 μm/1 bar [AL 110/1] or 50 μm/0.5 bar [AL50/0.5]). 280 surface treated steel cylinders (Rocatec-Plus, Solventum at 3.5 bar; = 20 steel cylinders per cement) were bonded to the zirconia specimens with 3 primer-free (PanaviaSA, Kuraray [PSA]; Nexus-Universal, Kerr [NexU]; Maxcem-Elite, Kerr [MAX]) and 3 primer-based (require a primer) cements (RelyX-Universal, Solventum [RelyX]; PanaviaV5, Kuraray [PV5]; Calibra-Universal, Dentsply-Sirona [CalU]) each applied according to the manufacturers´ instructions. 140 lithium-disilicate glass-ceramic specimens (IPS e.max CAD Ivoclar [EMAX]) and 140 zirconia-reinforced lithium-silicate-glass-ceramic specimens (Vita Suprinity, Vita [VITA]) were bonded to surface-treated steel cylinders (see above, 20 steel cylinders per cement) using 2 primer-free (PanaviaSA, Kuraray [PSA]; Nexus-Universal, Kerr [NexU]) and 5 primer-based cements (RelyX-Universal, Solventum [RelyX]; Variolink-Esthetic-DC, Ivoclar [VarE]; Nexus3, Kerr [Nex3]; Panavia-V5, Kuraray [PV5]; Calibra-Universal, Dentsply-Sirona [CalU]) each according to the manufacturers´ instructions.</p><p><strong>Results: </strong>All failures were between ceramic and cement. The bond strengths of composite-cements were highest on VITA followed by ZIR50, EMAX and ZIR110 [p < 0.001]. Composite cements that required a primer and primer-free composite cements showed no significant difference in bond strength with ZIR50, EMAX and ZIR100; only for VITA the difference was significant [p < 0.001]. PanaviaSA had the highest bond strength on VITA, followed by RelyX-Universal and Nexus-Universal. On ZIR50 RelyX-Universal had the highest bond strength followed by Calibra-Universal and PanaviaSA. On EMAX the rank order was Calibra-Universal>PanaviaSA>RelyX-Universal, whereas on ZIR110 the rank order was RelyX-Universal>Calibra-Universal >PanaviaSA.</p><p><strong>Significance: </strong>The bond strengths of the investigated composite cements were significantly higher on the zirconia-reinforced-lithium-silicate glass-ceramic (VITA) than on the lithium-disilicate glass-ceramic (EMAX) and on zirconia. Primer-free composite cements showed similar or higher shear strengths than composite cements that required a primer (primer-based). The authors propose the implementation of more standardized experimental protocols when determining bond strengths, to enable the inter-study comparison of results in line with the suggestions offered by the Academy of Dental Materials.</p>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148838546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}