含羊前胃基质牙膜的体内外比较研究。

IF 6.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Materials Pub Date : 2025-07-14 DOI:10.1016/j.dental.2025.06.023

Tatiana Tkatchenko, Robert W F Veale, Dawn E Coates, Anumala Ram, Saeidah Nobakht, Dane A Gerneke, Lea Kreutmayer, Shruti Sharma, Barnaby C H May, Sandi G Dempsey, Warwick J Duncan

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引用次数: 0

摘要

目的：本研究的目的是表征和评价由羊前胃基质（OFM）和重建胶原膜（BG）组成的可吸收牙膜。方法：比较OFM牙膜（OFMdm）和BG的相对器械强度、缝线保留度、弹性、蛋白水解稳定性和生物活性。并在绵羊拔牙模型中进行了牙膜的比较。结果：与BG膜相比，OFMdm具有更强的拉伸断裂力、蛋白水解稳定性和生物活性。在拔牙模型中，两种膜在移植物保留和新骨再生方面的结果相似，并且在4周时与未移植组相比，两种治疗组的有害结缔组织较少。8周和16周时，两组间无显著差异。意义：本研究表明OFMdm相对于BG膜具有良好的体外特性，在大型拔牙动物模型中安全有效。

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Comparative in vitro and vivo evaluation of a dental membrane comprising ovine forestomach matrix.

Objectives: The objective of this study was to characterize, and evaluate a resorbable dental membrane composed of ovine forestomach matrix (OFM) relative to a reconstituted collagen membrane (BG).

Methods: OFM Dental Membrane (OFMdm) and BG were compared in a range of in vitro tests to determine relative device strength, suture retention, elasticity, proteolytic stability and bioactivity. The dental membranes were also compared in an ovine tooth extraction model.

Results: OFMdm demonstrated superior tensile break force, proteolytic stability, and bioactivity relative to BG membrane. In the tooth extraction model, both membranes yielded similar outcomes with respect to graft retention and new bone regeneration, and both treatment groups had less deleterious connective tissue compared to the un-grafted group at 4 weeks. There were no significant differences between the treatment groups at 8 or 16 weeks.

Significance: This study demonstrated that OFMdm had favorable in vitro characteristics relative to the BG membrane and was safe and effective in a large animal model of tooth extraction.

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来源期刊

Dental Materials 工程技术-材料科学：生物材料

CiteScore

9.80

自引率

10.00%

发文量

290

审稿时长

67 days

期刊介绍： Dental Materials publishes original research, review articles, and short communications. Academy of Dental Materials members click here to register for free access to Dental Materials online. The principal aim of Dental Materials is to promote rapid communication of scientific information between academia, industry, and the dental practitioner. Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Other acceptable topics include application technology in clinical dentistry and dental laboratory technology. Comprehensive reviews and editorial commentaries on pertinent subjects will be considered.