Journal of Tissue Engineering and Regenerative Medicine最新文献

{"title":"RETRACTION: Effect of Surface Modification of Nanofibres with Glutamic Acid Peptide on Calcium Phosphate Nucleation and Osteogenic Differentiation of Marrow Stromal Cells","authors":"Journal of Tissue Engineering and Regenerative Medicine","doi":"10.1155/term/9820625","DOIUrl":"https://doi.org/10.1155/term/9820625","url":null,"abstract":"<p>RETRACTION: O. Karaman, A. Kumar, S. Moeinzadeh, X. He, T. Cui, and E. Jabbari, “Effect of Surface Modification of Nanofibres with Glutamic Acid Peptide on Calcium Phosphate Nucleation and Osteogenic Differentiation of Marrow Stromal Cells,” <i>Journal of Tissue Engineering and Regenerative Medicine</i> 10, no. 2 (2016): E132–E146, https://doi.org/10.1002/term.1775.</p><p>The above article, published online on 30 July 2013 in Wiley Online Library (https://wileyonlinelibrary.com), has been retracted by John Wiley &amp; Sons, Ltd, following concerns raised by a third party. An investigation identified several instances of duplication of elements within Figures 5 and 8. The authors cooperated with the investigation; however, due to the time elapsed since publication, they were unable to provide the original raw data. While some supporting data were provided, this was not sufficient to restore confidence in the article’s results and conclusions. Therefore, the publisher considers this article unreliable. The authors disagree with the retraction.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/term/9820625","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Effect of Surface Modification of Nanofibres with Glutamic Acid Peptide on Calcium Phosphate Nucleation and Osteogenic Differentiation of Marrow Stromal Cells","authors":"Journal of Tissue Engineering and Regenerative Medicine","doi":"10.1155/term/9820625","DOIUrl":"https://doi.org/10.1155/term/9820625","url":null,"abstract":"<p>RETRACTION: O. Karaman, A. Kumar, S. Moeinzadeh, X. He, T. Cui, and E. Jabbari, “Effect of Surface Modification of Nanofibres with Glutamic Acid Peptide on Calcium Phosphate Nucleation and Osteogenic Differentiation of Marrow Stromal Cells,” <i>Journal of Tissue Engineering and Regenerative Medicine</i> 10, no. 2 (2016): E132–E146, https://doi.org/10.1002/term.1775.</p><p>The above article, published online on 30 July 2013 in Wiley Online Library (https://wileyonlinelibrary.com), has been retracted by John Wiley &amp; Sons, Ltd, following concerns raised by a third party. An investigation identified several instances of duplication of elements within Figures 5 and 8. The authors cooperated with the investigation; however, due to the time elapsed since publication, they were unable to provide the original raw data. While some supporting data were provided, this was not sufficient to restore confidence in the article’s results and conclusions. Therefore, the publisher considers this article unreliable. The authors disagree with the retraction.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/term/9820625","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical Tuning of the Cell Microenvironment Using a Biomimetic Hydrogel System for Articular Cartilage Tissue Engineering","authors":"Marloes van Mourik,&nbsp;Janne Spierings,&nbsp;Pinar Koca,&nbsp;Florencia Abinzano,&nbsp;Gabriele Addario,&nbsp;Corrinus C. van Donkelaar,&nbsp;Keita Ito,&nbsp;Jasper Foolen","doi":"10.1155/term/9947868","DOIUrl":"https://doi.org/10.1155/term/9947868","url":null,"abstract":"<p>Providing a functional pericellular matrix (PCM) by fine-tuning the microenvironment of the articular chondrocytes (ACs) can greatly improve the outcomes of articular cartilage tissue engineering. While harvesting ACs with their PCM (chondrons) results in a low cell yield and a heterogeneous mixture of ACs and chondrons, microscale hydrogels could be used for mechanical tuning of the cell microenvironment. This may enable the use of stiffer bulk materials, improving the load-bearing capacity of the construct. This study investigates the effect of microenvironmental stiffness, independent of total construct stiffness, on the regenerative performance of ACs (ECM and PCM synthesis). Additionally, we explored articular cartilage–derived progenitor cells (ACPCs) as a possible alternative to ACs in the presented system. ACs were cultured in a soft or stiff bulk hydrogel (GelMA) or were encapsulated in soft microgels and seeded into the stiff GelMA. Constructs were seeded in an ex vivo porcine chondral defect model and cultured for 28 days with dynamic mechanical stimulation using a compression-sliding bioreactor. PCM and ECM quality were assessed through cell content analysis, immunofluorescent staining, histology, and measurements of GAG and collagen content. Cell encapsulation influenced ECM synthesis and PCM amount and completeness throughout the construct. Although the nonencapsulated groups showed stronger overall alcian blue staining, the encapsulated groups demonstrated more uniform matrix deposition throughout the depth of the tissue. Furthermore, ACPCs performed similarly to ACs. These findings suggest that the approach to differentially tune encapsulating and bulk hydrogel properties holds potential for future articular cartilage tissue engineering, and that ACPCs could be used as an alternative cell source.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2026 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/term/9947868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148167040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical Tuning of the Cell Microenvironment Using a Biomimetic Hydrogel System for Articular Cartilage Tissue Engineering","authors":"Marloes van Mourik,&nbsp;Janne Spierings,&nbsp;Pinar Koca,&nbsp;Florencia Abinzano,&nbsp;Gabriele Addario,&nbsp;Corrinus C. van Donkelaar,&nbsp;Keita Ito,&nbsp;Jasper Foolen","doi":"10.1155/term/9947868","DOIUrl":"https://doi.org/10.1155/term/9947868","url":null,"abstract":"<p>Providing a functional pericellular matrix (PCM) by fine-tuning the microenvironment of the articular chondrocytes (ACs) can greatly improve the outcomes of articular cartilage tissue engineering. While harvesting ACs with their PCM (chondrons) results in a low cell yield and a heterogeneous mixture of ACs and chondrons, microscale hydrogels could be used for mechanical tuning of the cell microenvironment. This may enable the use of stiffer bulk materials, improving the load-bearing capacity of the construct. This study investigates the effect of microenvironmental stiffness, independent of total construct stiffness, on the regenerative performance of ACs (ECM and PCM synthesis). Additionally, we explored articular cartilage–derived progenitor cells (ACPCs) as a possible alternative to ACs in the presented system. ACs were cultured in a soft or stiff bulk hydrogel (GelMA) or were encapsulated in soft microgels and seeded into the stiff GelMA. Constructs were seeded in an ex vivo porcine chondral defect model and cultured for 28 days with dynamic mechanical stimulation using a compression-sliding bioreactor. PCM and ECM quality were assessed through cell content analysis, immunofluorescent staining, histology, and measurements of GAG and collagen content. Cell encapsulation influenced ECM synthesis and PCM amount and completeness throughout the construct. Although the nonencapsulated groups showed stronger overall alcian blue staining, the encapsulated groups demonstrated more uniform matrix deposition throughout the depth of the tissue. Furthermore, ACPCs performed similarly to ACs. These findings suggest that the approach to differentially tune encapsulating and bulk hydrogel properties holds potential for future articular cartilage tissue engineering, and that ACPCs could be used as an alternative cell source.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2026 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/term/9947868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148167125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pirfenidone Attenuates Fibrosis and Neovascularization in 3D Spheroid-Laden Hydrogel Culture.","authors":"Rayan Abdulhadi, Jorge Rodrigo Pintado, Mohammed AbuAlia, Shadi Motamed, Meghan Moran, Marcella K Vaicik, Markus A Wimmer, Anna Plaas, Georgia Papavasiliou","doi":"10.1155/term/5557686","DOIUrl":"10.1155/term/5557686","url":null,"abstract":"<p><p>Fibrosis and angiogenesis are key contributors to synovial inflammation in both the early and progressive stages of rheumatoid arthritis (RA) and osteoarthritis (OA), making them important therapeutic targets to mitigate joint tissue damage. In vitro drug screening, particularly for antifibrotic and antiangiogenic efficacy, is a standard method for evaluating therapeutic candidates prior to in vivo testing. Traditionally, most studies have relied on two-dimensional (2D) monolayer cell cultures, which lack physiologically relevant cell-matrix and cell-cell interactions. Substantial evidence now indicates that three-dimensional (3D) culture systems more accurately recapitulate the structural and functional complexity of native tissue environments. We employed 3D spheroid culture models of fibrosis and neovascularization to evaluate the antiangiogenic and antifibrotic effects of pirfenidone (PFD), an FDA-approved drug for idiopathic pulmonary fibrosis. Spheroid monocultures of 3T3 fibroblasts and co-cultures of human umbilical vein endothelial cells (HUVECs) and human aortic smooth muscle cells (SMCs) were encapsulated in cell-adhesive, proteolytically degradable polyethylene glycol (PEG) hydrogel scaffolds. The temporal effects of PFD dose and timing of addition in culture on fibroblast outgrowth, vascular sprouting, and viability were quantified up to 14 days. PFD treatment led to dose-dependent inhibition of both fibroblast outgrowth and vascular sprouting, depending on the initial timing of PFD addition, with cell viability maintained under all conditions. In addition, PFD reversed the onset of fibrosis and neovascularization. PFD exhibited antifibrotic activity and antiangiogenic potential in 3D cultures.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2026 ","pages":"5557686"},"PeriodicalIF":2.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2026 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148077565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2026 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148077564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranial Defect Reconstruction With Custom 3D-Printed Hydroxyapatite Scaffolds Augmented With rhBMP-2 or Dipyridamole in a Nonhuman Primate Model","authors":"Griffin P. Bins,&nbsp;Heather A. Burkart,&nbsp;William Molair,&nbsp;Samuel Kogan,&nbsp;Dominic A. Massary,&nbsp;Angel Cabrera Pereira,&nbsp;Adem Aksu,&nbsp;Frank Reinauer,&nbsp;Daniel A. Couture,&nbsp;Lukasz Witek,&nbsp;Christopher M. Runyan","doi":"10.1155/term/2466910","DOIUrl":"10.1155/term/2466910","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Reconstruction of critical-sized bone defects, particularly in the cranio-maxillofacial region, presents unique challenges due to the need for integration with adjacent well-vascularized tissue and the absence of significant load-bearing requirements. This study evaluated the clinical readiness of bone tissue engineering (BTE) for critically sized cranial defects using custom 3D-printed hydroxyapatite scaffolds augmented with either recombinant human bone morphogenetic protein-2 (rhBMP-2) or dipyridamole (DIPY) in a highly translational nonhuman primate model.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Identical 5 × 5-cm vertex guided craniotomies were created in 12 macaques: Three cynomolgus macaques served as negative controls to validate the critical size nature of the defect, while nine rhesus macaques underwent scaffold reconstruction. Subjects were divided into three groups: uncoated scaffolds (&lt;i&gt;n&lt;/i&gt; = 3), scaffolds augmented with rhBMP-2 (Infuse® Medtronic, &lt;i&gt;n&lt;/i&gt; = 3), and scaffolds coated with DIPY, an adenosine A&lt;sub&gt;2A&lt;/sub&gt; receptor (A&lt;sub&gt;2A&lt;/sub&gt;R) indirect agonist (&lt;i&gt;n&lt;/i&gt; = 3). Bone growth and integration were assessed over 12 months through serial CT scans, followed by ex vivo micro-CT scanning, histology, and nanoindentation testing.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Negative control subjects did not demonstrate new bone formation, confirming the critical defect model. Subjects treated with scaffolds through all treatment groups remained intact throughout the 12-month follow-up. The rhBMP-2-treated group exhibited bridging, ∼90% circumferentially, significantly greater than DIPY (∼9%) or the uncoated scaffold (10%) (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Bone volume within rhBMP-2-treated scaffolds (7621 ± 145 mm&lt;sup&gt;3&lt;/sup&gt;) significantly exceeded that of DIPY (6466 ± 693 mm&lt;sup&gt;3&lt;/sup&gt;, &lt;i&gt;p&lt;/i&gt; = 0.03) and uncoated scaffold (6348 ± 663 mm&lt;sup&gt;3&lt;/sup&gt;, &lt;i&gt;p&lt;/i&gt; = 0.02) groups at 12 months. Quantitative histological micrograph analysis demonstrated that rhBMP-2 scaffolds were associated with the highest bone ingrowth (∼64%) relative to DIPY (∼39%) and uncoated scaffolds (∼27%). Nanoindentation yielded superior mechanical properties (Young’s modulus and hardness) of newly generated bone with defects treated with rhBMP-2 scaffolds (&lt;i&gt;p&lt;/i&gt; &lt; 0.05).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Reconstructing critically sized cranial defects with custom 3D-printed hydroxyapatite scaffolds was successful and yielded favorable results in this model. Scaffolds augmented with rhBMP-2 demonstrated su","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2026 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12856061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen-Based Scaffolds for Meniscal Repair and Regeneration","authors":"Yizhuo Wang,&nbsp;Jenny Shepherd","doi":"10.1155/term/3446671","DOIUrl":"https://doi.org/10.1155/term/3446671","url":null,"abstract":"<p>Meniscal injuries present a significant clinical challenge due to the limited self-healing capacity of avascular regions and the unsatisfactory long-term outcomes of current repair strategies. Collagen, the primary structural component of the meniscal extracellular matrix (ECM), plays a crucial role in maintaining its biomechanical integrity and guiding tissue regeneration. This review summarizes recent advances in collagen scaffolds technology, focusing on materials, collagen extraction, and scaffold fabrication methods, as well as their in vivo interactions with cells that regulate tissue regeneration. The mechanical enhancement of collagen scaffolds through crosslinking and reinforcement with synthetic polymers is discussed, alongside strategies for controlled degradation and biological integration. Despite remaining challenges in mechanical durability and long-term stability, these developments position collagen-based scaffolds as a promising avenue toward clinically viable meniscal repair solutions.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2025 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/term/3446671","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femtosecond Laser Engraving Promotes the Repopulation of Decellularized Human Articular Cartilage","authors":"Conny Schneider,&nbsp;Johann Zehetner,&nbsp;Barbara Schädl,&nbsp;Matthias Domke,&nbsp;Claudia Keibl,&nbsp;Bernhard Rieder,&nbsp;Patrick Heimel,&nbsp;Anne Kleiner,&nbsp;Andreas Teuschl-Woller,&nbsp;Susanne Wolbank,&nbsp;Heinz Redl,&nbsp;Sylvia Nürnberger","doi":"10.1155/term/2334978","DOIUrl":"10.1155/term/2334978","url":null,"abstract":"<p>Decellularized articular cartilage of human origin presents itself as the most homologous filling material for focal cartilage defects. Yet, the full repopulation of the exceptionally dense collagen construct has never been achieved without providing host cells with artificially created migration paths into the matrix. Within this study, we examine the use of a femtosecond laser to engrave fine patterns into human articular cartilage before decellularization and GAG depletion (decell-deGAG). Scaffolds were tested for decellularization success and mechanical behavior. Seeding tests were performed to assess biocompatibility and examine the performance in a simulated defect environment using an osteochondral plug model in vitro and in vivo in an ectopic nude mouse model. The composition and structure of the newly formed repair tissue and macrophage recruitment were observed via histology. The femtosecond laser was successful in engraving deep, fine structures into the matrix without the thermal damage found with other laser techniques. Engraving was also beneficial for decellularization success. The resulting decell-deGAG scaffold featured a compressive modulus many times stronger than other biomaterials commonly used for cartilage regeneration and presents a defect filling material that is similar to the tissue it is meant to replace. Moreover, the incisions promoted the repopulation with therapeutically relevant cells. A favorable spatial environment inside the incisions facilitated the formation of repair tissue that mimics hyaline cartilage in composition and collagen orientation. Scaffolds were well-integrated within simulated defects. Femtosecond laser–engraved cartilage poses an authentic defect filling material with cartilage-like properties. When used in combination with cell seeding, it promotes the formation of differentiated repair tissue. Thus, the hereby presented biomaterial shows great potential in improving the repair of focal cartilage defects and reducing long-term graft failures.</p>","PeriodicalId":202,"journal":{"name":"Journal of Tissue Engineering and Regenerative Medicine","volume":"2025 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12753096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}