IF 3.1 3区工程技术

Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-01-09 DOI: 10.1007/s11571-024-10194-x

Yifeng Liu, Hongjie Gong, Meimei Mouse, Fan Xu, Xianwei Zou, Jingsheng Yang, Qingping Xue, Min Huang

{"title":"The phonation test can distinguish the patient with Parkinson's disease via Bayes inference.","authors":"Yifeng Liu, Hongjie Gong, Meimei Mouse, Fan Xu, Xianwei Zou, Jingsheng Yang, Qingping Xue, Min Huang","doi":"10.1007/s11571-024-10194-x","DOIUrl":"10.1007/s11571-024-10194-x","url":null,"abstract":"Parkinson's disease (PD) is a neurodegenerative disease with various clinical manifestations caused by multiple risk factors. However, the effect of different factors and relationships between different features related to PD and the extent of those factors leading to the incidence of PD remains unclear. we employed Bayesian network to construct a prediction model. The prediction system was trained on the data of 35 patients and 26 controls. The structure learning and parameter learning of Bayesian Network was completed through the tree-augmented network (TAN) and Netica software, respectively. We employed four Bayesian Networks in terms of the syllable, including monosyllables, disyllables, multisyllables and unsegmented syllables. The area under the curve (AUC) of monosyllabic, disyllabic, multisyllabic, and unsegmented-syllable models were 0.95, 0.83, 0.80 and 0.84, respectively. In the monosyllabic tests, the best predictor of PD was duration, the posterior probability of which was 92.70%. Meanwhile, minimum f0 (61.60%) predicted best in the disyllabic tests and the variables that predicted best in multisyllables and unsegmented syllables were end f0 (59.40%) and maximum f0 (58.40%). In the cross-sectional comparison, the prediction effect of each variable in the monosyllabic tests was generally higher than that of other test groups. The monosyllabic models had the highest predicted performance of PD. Among acoustic parameters, duration was the strongest feature in predicting the prevalence of PD in monosyllabic tests. We believe that this network methodology will be a useful tool for the clinical prediction of Parkinson's disease.Supplementary information: The online version contains supplementary material available at 10.1007/s11571-024-10194-x.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"18"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic analysis of multi-spiral chaotic inertia model with a cyclic configuration involving four homogeneous HNN cells: stability analysis, analog and digital verifications. 包含四个均匀HNN单元的循环构型多螺旋混沌惯性模型的动力学分析：稳定性分析、模拟和数字验证。

IF 3.1 3区工程技术

Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-04-18 DOI: 10.1007/s11571-025-10240-2

Jean Baptiste Koinfo, Donghua Jiang, Jean Chamberlain Chedjou, Jacques Kengne, Khabibullo Nosirov

{"title":"Dynamic analysis of multi-spiral chaotic inertia model with a cyclic configuration involving four homogeneous HNN cells: stability analysis, analog and digital verifications.","authors":"Jean Baptiste Koinfo, Donghua Jiang, Jean Chamberlain Chedjou, Jacques Kengne, Khabibullo Nosirov","doi":"10.1007/s11571-025-10240-2","DOIUrl":"https://doi.org/10.1007/s11571-025-10240-2","url":null,"abstract":"This paper investigates the behavior of a Hopfield neural network consisting of four interconnected inertial neurons arranged in a loop configuration. The mathematical equation that governs the overall dynamic of the model is consists of a set of eight first-order ordinary differential equations (ODEs) with odd symmetry. The system has 81 equilibrium points, some of which undergo multiple Hopf bifurcations as a control parameter is varied. The maximum number of coexisting states is related to the maximum number of active equilibrium points. Through numerical investigations, intriguing nonlinear properties are discovered, including both homogeneous and heterogeneous multistability and the coexistence of up to sixteen bifurcation branches, the presence of multi-spiral chaos, crisis phenomenon, period splitting and the oscillation death phenomenon. In order to obtain a comprehensive understanding of the dynamics, various tools are used, such as phase portraits, bifurcation diagrams, Poincare maps, frequency spectra, Lyapunov exponent spectra, and attraction basins. A Significant achievement of this study is the demonstration that coupling inertial neurons can be an effective method to generate multi-spiral chaotic signals. The overall dynamics is non-hidden and meticulous adjustment of the gradient connected to the fourth neuron allows to complete annihilate oscillations (no motion) in the neural network in a particular interval. Finally, an electronic circuit inspired by the coupled inertial neuron system is designed using Orcad-PSpice software and implemented using an Arduino-based microcontroller. The simulation results from PSpice and microcontroller confirm the findings from the theoretical analysis.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"63"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of brain network effective connectivity in juvenile myoclonic epilepsy. 青少年肌阵挛性癫痫脑网络有效连通性分析。

IF 3.1 3区工程技术

Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-05-05 DOI: 10.1007/s11571-025-10256-8

Ming Ke, Xin Kang, Di Xu, Guangyao Liu

{"title":"Analysis of brain network effective connectivity in juvenile myoclonic epilepsy.","authors":"Ming Ke, Xin Kang, Di Xu, Guangyao Liu","doi":"10.1007/s11571-025-10256-8","DOIUrl":"https://doi.org/10.1007/s11571-025-10256-8","url":null,"abstract":"Juvenile Myoclonic Epilepsy (JME) is a prevalent idiopathic generalized epilepsy whose neurophysiological mechanisms remain elusive. This study aims to elucidate the aberrant brain network patterns in JME through a multi-modal fMRI approach combining local consistency, functional connectivity, and causal interaction analysis. Resting-state fMRI data were acquired from 37 JME patients and 35 healthy controls. Regional homogeneity (ReHo) and amplitude of low-frequency fluctuations (ALFF) analyses identified eight brain regions with significant between-group differences (FDR-corrected p < 0.05), including the right middle frontal gyrus, right insula, right medial/paracingulate gyrus, bilateral superior frontal gyri, left postcentral gyrus, and left superior occipital gyrus. These regions served as regions of interest (ROIs) for subsequent functional and effective connectivity analyses. Functional connectivity analysis revealed increased connectivity strength between the right middle frontal gyrus and right medial or paracingulate gyrus, as well as between the right insula and right medial/paracingulate gyrus (two-sample t test, p < 0.01), despite decreased local synchrony in these regions. Dynamic causal modeling (DCM) demonstrated bidirectional enhancement of effective connectivity between the right insula and right medial or paracingulate gyrus in patients (Bayesian posterior probability > 0.95). These findings suggest that the observed decoupling of local neuronal synchronization and long-range connectivity may reflect compensatory neuroadaptive processes, particularly involving the salience network (insula) and cognitive control circuitry (cingulate regions).The integration of ReHo/ALFF mapping with DCM provides a novel framework for understanding the neurodevelopmental trajectory of JME, highlighting the critical role of cortico-subcortical dysregulation in its pathogenesis.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"69"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teaching CORnet human fMRI representations for enhanced model-brain alignment. 教学CORnet人类fMRI表征增强模型-脑对齐。

IF 3.1 3区工程技术

Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-04-15 DOI: 10.1007/s11571-025-10252-y

Zitong Lu, Yile Wang

{"title":"Teaching CORnet human fMRI representations for enhanced model-brain alignment.","authors":"Zitong Lu, Yile Wang","doi":"10.1007/s11571-025-10252-y","DOIUrl":"https://doi.org/10.1007/s11571-025-10252-y","url":null,"abstract":"Deep convolutional neural networks (DCNNs) have demonstrated excellent performance in object recognition and have been found to share some similarities with brain visual processing. However, the substantial gap between DCNNs and human visual perception still exists. Functional magnetic resonance imaging (fMRI) as a widely used technique in cognitive neuroscience can record neural activation in the human visual cortex during the process of visual perception. Can we teach DCNNs human fMRI signals to achieve a more brain-like model? To answer this question, this study proposed ReAlnet-fMRI, a model based on the SOTA vision model CORnet but optimized using human fMRI data through a multi-layer encoding-based alignment framework. This framework has been shown to effectively enable the model to learn human brain representations. The fMRI-optimized ReAlnet-fMRI exhibited higher similarity to the human brain than both CORnet and the control model in within- and across-subject as well as within- and across-modality model-brain (fMRI and EEG) alignment evaluations. Additionally, we conducted an in-depth analysis to investigate how the internal representations of ReAlnet-fMRI differ from CORnet in encoding various object dimensions. These findings provide the possibility of enhancing the brain-likeness of visual models by integrating human neural data, helping to bridge the gap between computer vision and visual neuroscience.Supplementary information: The online version contains supplementary material available at 10.1007/s11571-025-10252-y.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"61"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of MicroRNA-31 with Endometrial Receptivity in Patients with Repeated Implantation Failure of In Vitro Fertilization and Embryo Transfer. 体外受精和胚胎移植反复着床失败患者的MicroRNA-31与子宫内膜容受性的关系

IF 1.6 4区生物学

Organogenesis Pub Date : 2025-12-01 Epub Date: 2025-02-23 DOI: 10.1080/15476278.2025.2460263

Yan Tan, Bijun Du, Xixi Chen, Minhong Chen

{"title":"Correlation of MicroRNA-31 with Endometrial Receptivity in Patients with Repeated Implantation Failure of In Vitro Fertilization and Embryo Transfer.","authors":"Yan Tan, Bijun Du, Xixi Chen, Minhong Chen","doi":"10.1080/15476278.2025.2460263","DOIUrl":"10.1080/15476278.2025.2460263","url":null,"abstract":"Objective: This trial probed the correlation between miR-31 expression and endometrial receptivity (ER) in patients with repeated implantation failure (RIF) of in vitro fertilization and embryo transfer (IVF-ET).Methods: A retrospective study of 80 infertility patients who underwent IVF-ET assisted conception treatment were divided into RIF group and normal pregnancy group (control group) according to the pregnancy outcome after embryo transfer. General information of both groups was collected. Endometrial tissues were collected in the middle luteal phase of the menstrual cycle before IVF-ET. miR-31 levels in endometrial tissues were measured, and endometrial tolerance indicator pulsatility index (PI), resistance index (RI), and endometrial thickness (Em) were detected. The correlation between endometrial miR-31 levels and ER indices was evaluated by Pearson method. ROC curves were utilized to analyze the efficacy of miR-31 in predicting RIF occurrence. The influencing factors of RIF were analyzed by binary Logistic regression.Results: RIF patients had increased miR-31 expression level and endometrial tolerance indicator PI, and RI while decreased Em (p < 0.05). miR-31 in RIF patients was positively correlated with PI and RI, and negatively correlated with Em (p < 0.05). The area under the curve for miR-31 to predict the occurrence of RIF was 0.899, with a sensitivity of 0.750 and a specificity of 0.950. PI, RI, and miR-31 were risk factors for developing RIF in IVF-ET women, and Em was a protective factor (p < 0.05).Conclusion: miR-31 in RIF patients is positively correlated with PI and RI, and negatively correlated with Em.","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"21 1","pages":"2460263"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial capping agents on silver nanoparticles made via green method using natural products from banana plant waste. 利用香蕉植物废料中的天然产物，通过绿色方法制备纳米银抗菌封盖剂。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-02-07 DOI: 10.1080/21691401.2025.2462335

Jimmy K Kabeya, Nadège K Ngombe, Paulin K Mutwale, Justin B Safari, Gauta Gold Matlou, Rui W M Krause, Christian I Nkanga

{"title":"Antimicrobial capping agents on silver nanoparticles made via green method using natural products from banana plant waste.","authors":"Jimmy K Kabeya, Nadège K Ngombe, Paulin K Mutwale, Justin B Safari, Gauta Gold Matlou, Rui W M Krause, Christian I Nkanga","doi":"10.1080/21691401.2025.2462335","DOIUrl":"10.1080/21691401.2025.2462335","url":null,"abstract":"Herein, we investigated the phytochemical composition and antibacterial activities of the organic layers from biosynthesized silver nanoparticles (AgNPs). AgNPs were synthesized using Musa paradisiaca and Musa sapientum extracts. UV-vis absorption in the 400-450 nm range indicated surface plasmonic resonance peak of AgNPs. Samples analyses using dynamic light scattering and transmission electron microscopy revealed the presence of particles within nanometric ranges, with sizes of 30-140 nm and 8-40 nm, respectively. Fourier transform infrared (FTIR) unveiled the presence of several organic functional groups on the surface of AgNPs, indicating the presence of phytochemicals from plant extracts. Thin layer chromatography (TLC) of the phytochemicals (capping agents) from AgNPs identified multiple groups of secondary metabolites. These phytochemical capping agents exhibited antibacterial activities against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, with minimum inhibitory concentrations ranging from 62.5 to 1000 µg/mL. Regardless of the bacterial species or plant parts (leaves or pseudo-stems), capping agents from M. sapientum nanoparticles displayed significantly enhanced antibacterial effectiveness compared to all other samples, including the raw plant extracts and biosynthesized capped and uncapped AgNPs. These results suggest the presence of antimicrobial phytochemicals on biosynthesized AgNPs, highlighting the promise of green nanoparticle synthesis as a valuable approach in bioprospecting antimicrobial agents.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"29-42"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microvesicles and exosomes isolated from murine bone marrow-derived mesenchymal stromal cells primed with p38MAPK inhibitor differentially regulate hematopoietic stem cell function. 从小鼠骨髓间充质基质细胞中分离的微囊泡和外泌体对造血干细胞功能的调控存在差异。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-03-10 DOI: 10.1080/21691401.2025.2475095

Pallavi Budgude, Vaijayanti Kale, Anuradha Vaidya

{"title":"Microvesicles and exosomes isolated from murine bone marrow-derived mesenchymal stromal cells primed with p38MAPK inhibitor differentially regulate hematopoietic stem cell function.","authors":"Pallavi Budgude, Vaijayanti Kale, Anuradha Vaidya","doi":"10.1080/21691401.2025.2475095","DOIUrl":"10.1080/21691401.2025.2475095","url":null,"abstract":"The signaling mechanisms active within mesenchymal stromal cells (MSCs) influence the composition of microvesicles (MVs) and exosomes (Exos) secreted by them. Previously, we showed that priming MSCs with a p38 pharmacological inhibitor (pMSCs) rejuvenates them and improves their ability to promote ex vivo hematopoietic stem cell (HSC) expansion. This study examined whether pMSCs exerted HSC-supportive ability via MVs (pMVs) and Exos (pExos). Our findings demonstrate distinct regulation of HSC fate by pMVs and pExos. pMVs promoted the expansion of long-term HSCs (LT-HSCs), distinguished by their robust self-renewal capacity and superior engraftment ability. In contrast, pExos facilitated expansion of short-term HSCs (ST-HSCs) with high proliferative and differentiation potential. Infusing a combination of pMVs- and pExos-expanded HSCs as a composite graft resulted in significantly higher HSC engraftment, emphasizing the synergistic interaction between LT- and ST-HSC populations. Gene expression studies, functional and phenotypic experiments showed that pMVs regulate HSC quiescence via the Egr1/Cdkn1a axis, while pExos control HSC proliferation via the Nfya/Cdkn1a axis. These findings provide insights into the molecular mechanisms underlying the differential regulation of HSC function by pMVs and pExos. It also proposes a composite graft strategy of using pMVs and pExos as \"MSC-derived biologics\" for improving the HSC transplantation success.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"122-137"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green synthesis of silver nanoparticles for functional cotton fabrics: antimicrobial efficacy against multidrug-resistant bacteria and cytotoxicity evaluation. 功能棉织物用纳米银的绿色合成：对多重耐药细菌的抗菌效果及细胞毒性评价。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-04-01 DOI: 10.1080/21691401.2025.2485115

Sérgio Antunes Filho, Clara M Almeida, Maria Teresa Villela Romanos, Bianca Pizzorno Backx, Raquel Regina Bonelli

{"title":"Green synthesis of silver nanoparticles for functional cotton fabrics: antimicrobial efficacy against multidrug-resistant bacteria and cytotoxicity evaluation.","authors":"Sérgio Antunes Filho, Clara M Almeida, Maria Teresa Villela Romanos, Bianca Pizzorno Backx, Raquel Regina Bonelli","doi":"10.1080/21691401.2025.2485115","DOIUrl":"10.1080/21691401.2025.2485115","url":null,"abstract":"Bacterial infections associated with healthcare are a challenge on a global scale due to the high morbidity and mortality rates, especially those caused by multidrug-resistant isolates. Hospital textiles are abiotic surfaces that may serve as a means of disseminating and persisting microorganisms in hospitals, as microorganisms can remain viable on these surfaces for up to months. In this study, we employed a green synthesis approach utilizing guava leaf extract (Psidium guajava) to produce silver nanoparticles, which were then incorporated into a cotton fabric. Antimicrobial properties and the cytotoxicity of the functional textile were assessed. The finding indicated that the green synthesis method was efficient and resulted in a predominant population of nanoparticles with diameters ranging from 25 to 84 nm that were uniformly dispersed in the textile. The functional textile exhibited low toxicity and high antimicrobial efficiency, even against multidrug-resistant microorganisms of particular concern in hospital settings. Atomic force microscopy carried out evidenced invaginations in the cell wall of bacteria submitted to this textile, suggesting surface damage as an important mechanism of action silver nanoparticles incorporated.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"153-165"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the anticancer and synergistic effects of the combination of green synthesized silver nanoparticles and papaverine on breast cancer cell lines: focusing on the apoptosis pathway and microRNA regulation. 研究绿色合成纳米银与罂粟碱联合对乳腺癌细胞株的抗癌和协同作用：重点研究凋亡途径和microRNA调控。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2025-12-01 Epub Date: 2025-06-01 DOI: 10.1080/21691401.2025.2507372

Maryam Fekri Soufiabadi, Reza Haji Hosseini, Zolfaghar Lotfi

{"title":"Investigating the anticancer and synergistic effects of the combination of green synthesized silver nanoparticles and papaverine on breast cancer cell lines: focusing on the apoptosis pathway and microRNA regulation.","authors":"Maryam Fekri Soufiabadi, Reza Haji Hosseini, Zolfaghar Lotfi","doi":"10.1080/21691401.2025.2507372","DOIUrl":"https://doi.org/10.1080/21691401.2025.2507372","url":null,"abstract":"The study investigates the anticancer effects of green silver nanoparticles (Ag-NPs) synthesized from Viola cornuta extract combined with papaverine on breast cancer cells. Ag-NPs were characterized using various analytical techniques, confirming their presence with UV-vis spectroscopy showing a peak at 413 nm and an average size of 42 nm via field emission scanning electron microscopy (FE-SEM) analysis. The particles demonstrated a face-centred cubic structure, with energy-dispersive X-ray spectroscopy (EDX) confirming elemental composition. Additionally, the zeta potential measurement of -6.75 mV indicated favourable electrostatic repulsion between nanoparticles, thereby confirming their stability. Antioxidant activity was significant, with an EC50 value of 38.78 μg/mL. The combination treatment of Ag-NPs and papaverine exhibited synergistic effects, lowering IC50 values to 2.8 + 112.7 μg/mL for MCF-7 cells and 6.2 + 112 μg/mL for MDA-MB-231 cells, without toxicity to normal cells. Flow cytometry revealed G0/G1 phase inhibition and increased sub-G1 populations, indicating cell cycle arrest, alongside increased reactive oxygen species generation and apoptosis. Notably, the experimental group showed altered expression of oncogenic and tumour suppressor microRNAs and apoptotic genes (p < .0001), underscoring the potential of this nanoparticle-papaverine combination as an effective anticancer strategy against breast cancer treatment resistance.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"1-19"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ECn-MultiBSTM: multiclass epileptic seizure classification using electro cetacean optimized bidirectional long short-term memory model. ECn-MultiBSTM：基于电鲸类优化的双向长短期记忆模型的多类别癫痫发作分类。

IF 3.1 3区工程技术

Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-05-27 DOI: 10.1007/s11571-025-10268-4

Pankaj Kunekar, Pankaj Dadheech, Mukesh Kumar Gupta

{"title":"ECn-MultiBSTM: multiclass epileptic seizure classification using electro cetacean optimized bidirectional long short-term memory model.","authors":"Pankaj Kunekar, Pankaj Dadheech, Mukesh Kumar Gupta","doi":"10.1007/s11571-025-10268-4","DOIUrl":"10.1007/s11571-025-10268-4","url":null,"abstract":"Multiclass epileptic seizureclassification aims to identify and categorize different epileptic seizure types like a non-epileptic seizure, epileptic interictal seizure, and epileptic ictal seizurein individuals based on Electroencephalography (EEG) signal characteristics. Multi-class seizure classification requires recognizing various seizure forms and patterns, which can be challenging due to noise and high variability patterns in EEG signals. Existing models face limitations such as difficulty in handling the complex and dynamic nature of seizure patterns, poor generalization to unseen data, and sensitivity to noise and artifacts, all of which impact classification accuracy and reliability. To address these issues, the Electro Cetacean Optimization based Multi Bidirectional Long Short-Term Memory (ECn-MultiBSTM) model is proposed. The BiLSTM modelis utilized for feature extraction, which captures sequential data by processing data in both forward and backward directions. This bidirectional approach enables the model to identify subtle patterns that distinguish various seizure types with higher accuracy. The ECn-MultiBSTM model also incorporates advanced Electro Cetacean optimizationtechniques that enhance its ability to search efficiently for optimal solutions.Through dynamic social coordination and rapid search strategies, the model fine-tunes its hyperparameters, ensuring improved performance and adaptability.The proposed ECn-MultiBSTM model significantly enhances multiclassseizure classification performance, achieving impressive metrics of 95.84% accuracy, 95.30% precision, 95.54% F1-score,0.94% MCC, 95.79% sensitivity, and 95.88% specificity when evaluated on the CHB-MIT SCALP EEG dataset.","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"83"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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