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Transformed and Tumor Cells Spontaneously Produce DNA-Containing Extracellular Structures In Vitro. 转化和肿瘤细胞在体外自发产生含dna的细胞外结构。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06489-6
A N Kazimirskii, J M Salmasi, G V Poryadin, M I Panina, A E Kim, A G Chakhalian
{"title":"Transformed and Tumor Cells Spontaneously Produce DNA-Containing Extracellular Structures In Vitro.","authors":"A N Kazimirskii, J M Salmasi, G V Poryadin, M I Panina, A E Kim, A G Chakhalian","doi":"10.1007/s10517-025-06489-6","DOIUrl":"10.1007/s10517-025-06489-6","url":null,"abstract":"<p><p>The parameters of DNA-containing extracellular structures formed by immortalized fibroblasts and HCT116 adenocarcinoma cells during cultivation were studied. Fluorescence microscopy with SYBR Green dye was used to visualize DNA-containing extracellular structures. In contrast to intact neutrophils, immortalized fibroblasts and adenocarcinoma cells spontaneously formed DNA-containing extracellular structures during incubation. The process begins with the release of a single DNA-containing strand from the cell immediately after the cells are fixed to the substrate (1 h) and ends after 3 h with the formation of DNA-containing extracellular structures in the form of bundles of parallel fibers. These findings indicate active nature of the secretion of DNA-containing structures by immortalized fibroblasts and HCT116 adenocarcinoma cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"359-362"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effect of Conditioned Medium from Bone Marrow Mesenchymal Stem Cells on the Cornea of Rabbits with Impaired Blink Reflex. 骨髓间充质干细胞条件培养基对眨眼反射受损兔角膜的保护作用。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06491-y
V V Tiulina, S V Lavrushkina, A I Dovgii, I I Senin
{"title":"Protective Effect of Conditioned Medium from Bone Marrow Mesenchymal Stem Cells on the Cornea of Rabbits with Impaired Blink Reflex.","authors":"V V Tiulina, S V Lavrushkina, A I Dovgii, I I Senin","doi":"10.1007/s10517-025-06491-y","DOIUrl":"10.1007/s10517-025-06491-y","url":null,"abstract":"<p><p>We studied the efficiency of a conditioned medium containing the secretome of bone marrow mesenchymal stem cells in preventing corneal damage in rabbits using an experimental model of dry eye syndrome caused by impaired blinking reflex. The conditioned medium produced a pronounced protective effect on the epithelial layer of the cornea of rabbits and suppressed the activation of MMP-9 in the tear film. As is known, an increase in MMP-9 activity leads to degradation of extracellular matrix components and disruption of the corneal epithelial barrier function. Our results indicate the possibility of using the bone marrow mesenchymal stem cell secretome in the treatment of dry eye syndrome.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"368-372"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution of Prohormone Convertase 1/3 in β and α Cells of the Human Fetal Pancreas at Gestational Weeks 8-20. 孕8 ~ 20周人胎儿胰腺β、α细胞中激素原转化酶1/3的分布
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-30 DOI: 10.1007/s10517-025-06470-3
Yu S Krivova, A E Proshchina, O S Godovalova, E G Otlyga, S V Saveliev
{"title":"Distribution of Prohormone Convertase 1/3 in β and α Cells of the Human Fetal Pancreas at Gestational Weeks 8-20.","authors":"Yu S Krivova, A E Proshchina, O S Godovalova, E G Otlyga, S V Saveliev","doi":"10.1007/s10517-025-06470-3","DOIUrl":"10.1007/s10517-025-06470-3","url":null,"abstract":"<p><p>Data on the distribution of insulin biosynthesis enzymes in the developing human pancreas are limited and do not provide comprehensive understanding of mechanisms of β-cell maturation. In this study, the distribution of prohormone convertase 1/3 (PC1/3) in β and α cells of the pancreas of 15 fetuses (gestational age 8-20 weeks) was analyzed using double immunofluorescence staining. It has been demonstrated that numerous cells positively stained for PC1/3 but not containing insulin are present in the pancreatic islets during prenatal development. These cells probably represent maturing β cells that accumulate the enzyme prior to the insulin biosynthesis. In some of these cells, co-localization of PC1/3 and glucagon was revealed, which indicates a possible temporary expression of glucagon in differentiating and maturing β cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"260-265"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Fluoxetine during the Infantile Period on Cognitive and Physiological Functions in Juvenile Male and Female Rats Exposed to Pain in Newborn Age. 婴儿期氟西汀对新生儿期疼痛暴露雄性和雌性幼年大鼠认知和生理功能的影响。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-28 DOI: 10.1007/s10517-025-06455-2
I P Butkevich, V A Mikhailenko, E A Vershinina
{"title":"The Effect of Fluoxetine during the Infantile Period on Cognitive and Physiological Functions in Juvenile Male and Female Rats Exposed to Pain in Newborn Age.","authors":"I P Butkevich, V A Mikhailenko, E A Vershinina","doi":"10.1007/s10517-025-06455-2","DOIUrl":"10.1007/s10517-025-06455-2","url":null,"abstract":"<p><p>Deviations in neuropsychological development in the adolescence are considered in a pediatric clinic as the first peak of deviations with possible suicidal acts, and in the early adulthood - as a second peak their manifestations. The influence of the serotonin reuptake inhibitor fluoxetine in the infantile period (P25-P39) was studied in rats subjected to inflammatory pain in the neonatal period, on cognitive function and the reactivity of the hypothalamic-pituitary-adrenal (HPA) axis in juvenile period (P54-P63), which correspond to the listed age periods in humans. Fluoxetine did not affect the spatial memory of control rats of both sexes and normalized the memory of the first day impaired by inflammatory pain in females; combination of pain and fluoxetine worsened long-term memory in females in comparison with males and in comparison with memory of the first day; shorter retention of spatial memory in females compared to males was associated with lower HPA axis reactivity. Our findings suggest that the effect of fluoxetine on the integrative function of the brain and reactivity of the HPA axis in the juvenile period depends on rat sex and neonatal pain.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"186-191"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arginase-1 and Mer Tyrosine Kinase Expression in Monocyte Populations in Patients with Axial Spondyloarthritis. 轴型脊椎关节炎患者单核细胞群中精氨酸酶-1和Mer酪氨酸激酶的表达。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-29 DOI: 10.1007/s10517-025-06460-5
L V Sakhno, E Ya Shevela, T V Tyrinova, O Yu Leplina, M A Tikhonova, A Yu Morenkova, O A Chumasova, N A Ilyina, N S Shkaruba, A E Sizikov, Yu D Kurochkina, A V Fedorova, V O Omelchenko, E A Letyagina, M A Korolev, E R Chernykh
{"title":"Arginase-1 and Mer Tyrosine Kinase Expression in Monocyte Populations in Patients with Axial Spondyloarthritis.","authors":"L V Sakhno, E Ya Shevela, T V Tyrinova, O Yu Leplina, M A Tikhonova, A Yu Morenkova, O A Chumasova, N A Ilyina, N S Shkaruba, A E Sizikov, Yu D Kurochkina, A V Fedorova, V O Omelchenko, E A Letyagina, M A Korolev, E R Chernykh","doi":"10.1007/s10517-025-06460-5","DOIUrl":"10.1007/s10517-025-06460-5","url":null,"abstract":"<p><p>Axial spondyloarthritis is characterized by activation of innate immune cells, which manifested in elevation of classical monocytes and predominance of the proinflammatory phenotype. However, the immunosuppressive potential of monocyte/macrophages remains practically unexplored. We evaluated the expression of Mer tyrosine kinase (MerTK) and arginase-1 (Arg1) in monocyte subsets in patients with axial spondyloarthritis, considering different clinical features. The expression of MerTK and Arg1 in intermediate and non-classical monocytes from patients with axial spondyloarthritis was reduced in comparison with the normal. The most pronounced decrease in monocyte expression of MerTK and Arg1 was associated with a more aggressive course of the disease (presence of coxitis, high disease activity, HLA-B27 positivity) and lack of response to conventional therapy. These data demonstrate an important role of MerTK and Arg1 in limiting myeloid-driven inflammation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"211-216"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacobiochemical Analysis of the Cytoprotective Action of New 5-Androstendiol Derivatives. 新型5-雄烯二醇衍生物细胞保护作用的药效学分析。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-29 DOI: 10.1007/s10517-025-06457-0
M N Sergeicheva, M R Nazdracheva, M E Uspenskaya, A V Berezhnova, M V Burak, A Yu Ivanii, T A Fedotcheva
{"title":"Pharmacobiochemical Analysis of the Cytoprotective Action of New 5-Androstendiol Derivatives.","authors":"M N Sergeicheva, M R Nazdracheva, M E Uspenskaya, A V Berezhnova, M V Burak, A Yu Ivanii, T A Fedotcheva","doi":"10.1007/s10517-025-06457-0","DOIUrl":"10.1007/s10517-025-06457-0","url":null,"abstract":"<p><p>5-Androstenediol esters, dibutanoate and dipropionate, were synthesized as prototypes of effective cytoprotectors with prolonged action. The cytoprotective effect of the new 5-androstenediol derivatives was assessed in human lung and skin fibroblasts and human blood mononuclear cells exposed to UV radiation. 5-Androstenediol esters showed a regenerating, cytoprotective effect on different types of fibroblasts, but not on human peripheral blood mononuclear cells. The DNA comet assay revealed no genotoxic effect of the new steroids on the mononuclear fraction of human blood, which indicates their safety. The cytoprotective activity of 5-androstenediol dibutanoate and dipropionate in human fibroblasts attests to their possible use for creating ointments and liniments for the treatment of skin injuries requiring regeneration (including irradiation damage).</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"196-200"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Dynamics of Radiation-Induced Changes in Mice Behavior in the Marble Burying Test after Fractionated Gamma Irradiation. 分级伽玛辐射后大理岩掩埋试验中小鼠行为变化的动力学研究。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-29 DOI: 10.1007/s10517-025-06467-y
N I Atamanyuk
{"title":"The Dynamics of Radiation-Induced Changes in Mice Behavior in the Marble Burying Test after Fractionated Gamma Irradiation.","authors":"N I Atamanyuk","doi":"10.1007/s10517-025-06467-y","DOIUrl":"10.1007/s10517-025-06467-y","url":null,"abstract":"<p><p>We studied the effect of fractionated gamma irradiation at cumulative doses of 0.1, 1, and 5 Gy during the first month of life on the indices of anxious behavior in C57BL/6 mice in the early and delayed terms after the exposure. Anxiety was evaluated using the marble burying test. Persistent dose-dependent behavioral changes were revealed: irradiation at a dose of 0.1 Gy led to an increase in the anxiety level at the age of 1 and 6 months, whereas exposure at a dose of 5 Gy suppressed animal activity in the marble burying test until the age of 12 months. Irradiation at a dose of 1 Gy decreased anxiety parameters only in the delayed period after the irradiation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"246-249"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathomorphological Evaluation of the Efficiency of Modeling Osteoarthritis of Vascular-Metabolic Genesis in Female Wistar Rats. 雌性Wistar大鼠血管代谢生成骨关节炎模型的病理形态学评价。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-29 DOI: 10.1007/s10517-025-06472-1
K V Korochina
{"title":"Pathomorphological Evaluation of the Efficiency of Modeling Osteoarthritis of Vascular-Metabolic Genesis in Female Wistar Rats.","authors":"K V Korochina","doi":"10.1007/s10517-025-06472-1","DOIUrl":"10.1007/s10517-025-06472-1","url":null,"abstract":"<p><p>The article examines the issue of sexual dimorphism in experimental non-traumatic osteoarthritis (OA). The study analyzed the articular structures and internal organs of 8-month-old female Wistar rats after inducing chronic heart failure and obesity, which served as the author's OA model. The results were compared with those from a control group of females and existing literature on OA modeling in males, using histochemical and morphometric techniques, as well as semi-quantitative assessments using the Mankin and OARSI scales and the Krenn synovitis scale. The findings indicate the onset of early OA in the experimental female group, supporting the effectiveness of this modeling approach based on vascular-metabolic factors. Additionally, the comparative analysis showed that joint tissue changes were more significant in males than in females, suggesting that male rats are more suitable for OA modeling.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"270-276"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in the Expression of the tgfb1 Gene and the Level of TGF-β1 in the Liver during Exercise of Varying Intensity. 不同强度运动时肝脏TGF-β1基因表达及TGF-β1水平的变化
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-09-02 DOI: 10.1007/s10517-025-06464-1
O V Alpidovskaya, I I Malyshev, L P Romanova
{"title":"Changes in the Expression of the tgfb1 Gene and the Level of TGF-β1 in the Liver during Exercise of Varying Intensity.","authors":"O V Alpidovskaya, I I Malyshev, L P Romanova","doi":"10.1007/s10517-025-06464-1","DOIUrl":"10.1007/s10517-025-06464-1","url":null,"abstract":"<p><p>Male Wistar rats were subjected to physical exercise of mild (group 1), moderate (group 2), and high (group 3) intensity. Ten swimming sessions were conducted, after which the animals were sacrificed (immediately and 30 days after the last session). Liver samples were studied by histological methods; the expression of the tgfb1 gene and the level of TGF-β1 in the liver were evaluated. Moderate degenerative processes were observed in the liver of rats with mild to moderate physical activity, and no significant changes were detected in the expression of tgfb1 gene and TGF-β1 content in the liver. In case of hard physical exercise, degenerative changes, necrosis, and cell infiltration were observed in the liver, and the level of TGF-β1 decreased. In 30 days after the last swimming session, an increase in both the level of TGF-β1 in the cytoplasmic fraction of the liver and the expression of the tgfb1 gene was observed.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"232-236"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Potentilla anserina L. Extract on the Activity of Oxidative and Hydrolytic Enzymes in Blood Cells of Rats under Induced Stress. 蕨麻提取物对应激大鼠血细胞氧化酶和水解酶活性的影响。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-28 DOI: 10.1007/s10517-025-06456-1
E E Saveleva, N A Bulgakova, O F Veselova, M V Dolgushin
{"title":"Effect of Potentilla anserina L. Extract on the Activity of Oxidative and Hydrolytic Enzymes in Blood Cells of Rats under Induced Stress.","authors":"E E Saveleva, N A Bulgakova, O F Veselova, M V Dolgushin","doi":"10.1007/s10517-025-06456-1","DOIUrl":"10.1007/s10517-025-06456-1","url":null,"abstract":"<p><p>We studied the effect of thick extract of Potentilla anserina L. on activities of antioxidant defense system enzymes in rat blood under conditions of induced stress. Antioxidant properties of the extract were preliminarily assessed by the reaction with 2,2-diphenyl-1-picrylhydrazyl. Stress in animals was induced by forced swimming; the extract was administered preventively orally over 10 days. Preventive use of the extract in aqueous suspension produced an appreciable effect on stress-induced oxidative processes in neutrophils and lymphocytes. The extract acts as an acceptor of free radicals and has a positive effect on the adaptive mechanisms of the body under conditions of physiological response to an unfavorable situation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"192-195"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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