Bulletin of Experimental Biology and Medicine最新文献_第3页

The Study of Effectiveness of Combined Proton-Neutron Irradiation of Tumor Cells In Vitro. 质子-中子联合辐照体外肿瘤细胞的有效性研究

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06285-8

S N Koryakin, M V Troshina, E V Koryakina, V I Potetnya, A A Pichkunova, V O Saburov, E I Kazakov, A A Lychagin, S A Ivanov, A D Kaprin, V I Zverev, A Yu Presnyakov

引用次数: 0

Features of Stress-Induced Changes in Heart Rate Variability During Blockade of Central and Stimulation of Peripheral Serotonin and Dopamine Receptors in Rats. 阻断大鼠中枢羟色胺和多巴胺受体及刺激外周羟色胺和多巴胺受体时压力诱发的心率变异性变化的特征

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06279-6

E V Kuryanova, V O Stupin, A V Tryasuchev

{"title":"Features of Stress-Induced Changes in Heart Rate Variability During Blockade of Central and Stimulation of Peripheral Serotonin and Dopamine Receptors in Rats.","authors":"E V Kuryanova, V O Stupin, A V Tryasuchev","doi":"10.1007/s10517-024-06279-6","DOIUrl":"https://doi.org/10.1007/s10517-024-06279-6","url":null,"abstract":"The dynamics of heart rate variability (HRV) during acute stress was studied in male nonlinear rats that received single injection of serotonin (200 μg/kg) or dopamine (60 μg/kg), regular (4-fold) injections of central serotonin receptor blockers (ketanserin and granisetron, 0.1 mg/kg each) or central dopamine receptor blockers (0.1 mg/kg SCH-23390 and 10 mg/kg sulpiride), as well as a combination of central receptor blockers with the administration of serotonin or dopamine, respectively. During stress against the background of serotonin receptors blockade, a weak tachycardia, low stress index, high rhythm variability, especially in the low-frequency range were recorded; against the background of dopamine receptors blockade, increased reactivity to stress at high HR, an initial increase in the stress index, and a decrease in rhythm variability, followed by an increase in the proportion of very low frequency waves in the spectrum were revealed. Serotonin and dopamine, by stimulating peripheral receptors, predominantly weakened stress-induced changes in HRV (especially serotonin), but in combination with blockade of the corresponding central receptors contributed to maintaining tachycardia, reduced rhythm variability, and potentiated the effects of blockers in relation to stress induced changes in the wave structure of the HRV spectrum. We believe that central and peripheral serotoninergic and dopaminergic structures are involved in the formation of HRV by modulating the activity of components of the autonomous and central circuits of HR regulation, respectively.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling of Isoproterenol-Induced Chronic Heart Failure in 24-Month-Old Rats. 异丙肾上腺素诱发 24 个月大鼠慢性心力衰竭的模型试验

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06277-8

T Yu Rebrova, V A Korepanov, I V Stepanov, S A Afanasiev

引用次数: 0

Functional Assessment of Rat Sciatic Nerve Regeneration Using a Nerve Conduit Based on Ion Exchange Membrane. 利用基于离子交换膜的神经导管对大鼠坐骨神经再生进行功能评估

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06290-x

T V Rusinova, K I Melkonyan, R A Vinogradov, A S Asyakina, S A Knyshova

引用次数: 0

Cardioprotective Effect of Selective μ₂-Opioid Receptor Agonist Endomorphin-1 in Cardiac Reperfusion In Vivo and In Vitro. 选择性μ2-阿片受体激动剂内啡肽-1对体内和体外心脏再灌注的心脏保护作用

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06287-6

A S Gorbunov, A V Mukhomedzyanov, S V Popov, V N Azev, L N Maslov

引用次数: 0

Evaluation of the Biological Properties of the Bacteriodaceae Family Using the Caco-2 Cell Line. 利用 Caco-2 细胞系评估细菌科植物的生物特性

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06281-y

I V Podoprigora, M S Das, N B Zakharzhevskaya, L I Kafarskaya, B A Efimov

引用次数: 0

Activity of NAD(P)-Dependent Dehydrogenases of Ovarian Vein Lymphocytes in Women with Pelvic Varicose Veins. 盆腔静脉曲张妇女卵巢静脉淋巴细胞中 NAD(P)-D 依赖性脱氢酶的活性。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06278-7

A A Semendyaev, M A Darenskaya, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, L I Kolesnikova

{"title":"Activity of NAD(P)-Dependent Dehydrogenases of Ovarian Vein Lymphocytes in Women with Pelvic Varicose Veins.","authors":"A A Semendyaev, M A Darenskaya, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, L I Kolesnikova","doi":"10.1007/s10517-024-06278-7","DOIUrl":"https://doi.org/10.1007/s10517-024-06278-7","url":null,"abstract":"The activities of NAD- and NADP-dependent isocitrate dehydrogenases (NAD-ICDH and NADP-ICDH), NAD- and NADP-dependent glutamate dehydrogenases (NAD-GDH and NADP-GDH), and NAD- and NADP-dependent malate dehydrogenases (NAD-MDH and NADP-MDH) in ovarian veins lymphocytes in 183 women of reproductive age with pelvic varicose veins (PVV) and 30 women in the control group were determined. The indicators of intracellular enzymatic activity showed multidirectional changes with increasing severity of the disease. Compared to the control group, women with stage II of PVV had higher median values for lactate dehydrogenase (16.69), NAD-GDH (39.48), NADP-GDH (7.48), NADP-MDH (9.06) and lower values of NAD-ICDH (65.41). Women with stage III of PVV had lower median values for succinate dehydrogenase (9.27), NAD-MDH (26.19), and higher values for glucose-6-phosphate dehydrogenase (8.62), lactate dehydrogenase (24.67), NAD-GDH (63.81), NADP-MDH (21.05) compared to the control group. Studying the activity of NAD(P)-dependent dehydrogenases in lymphocytes at the local level during PVV allows us to evaluate the intensity and dynamics of local varicose veins progression, as well as to optimize its correction.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specific Disruption of Memory Reconsolidation of Conditioned Food Aversion in Snails by DNA Synthesis Inhibitors. DNA 合成抑制剂对蜗牛条件反射食物厌恶记忆再巩固的特异性破坏

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-20 DOI: 10.1007/s10517-024-06274-x

S V Solntseva, O I Efimova, V P Nikitin

{"title":"Specific Disruption of Memory Reconsolidation of Conditioned Food Aversion in Snails by DNA Synthesis Inhibitors.","authors":"S V Solntseva, O I Efimova, V P Nikitin","doi":"10.1007/s10517-024-06274-x","DOIUrl":"https://doi.org/10.1007/s10517-024-06274-x","url":null,"abstract":"The involvement of DNA synthesis in the mechanisms of long-term memory reconsolidation in edible snails trained for conditioned food aversion was investigated. Administration of nucleoside analogs, such as 5-bromo-2'-deoxyuridine or 3'-azido-3'-deoxythymidine, which inhibit DNA synthesis, 1 h before or 1-3 h, but not 5 h after reminder with the conditioned stimulus led to memory impairment. One day after the inhibitor application and memory reactivation, a weakly expressed memory impairment (amnesia) was observed, which progressed over the next few days to the complete disappearance of behavioral memory expression. In snails with formed aversive memory for two food conditioned stimulus, a specific memory impairment was observed only for the stimulus that was paired with the presentation of an inhibitor during the reminder, while the memory for the other non-reactivated conditioned stimulus remained intact. It is suggested that DNA synthesis in the brain plays a specific role in the genetic mechanisms of reconsolidation and maintenance of long-term conditioned food aversion memory in snails.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptides in the Treatment of Gastric Ulcer. 多肽治疗胃溃疡。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-20 DOI: 10.1007/s10517-024-06272-z

A S Kalnitsky, A Yu Zharikov

引用次数: 0

Serum Concentrations of Pro- and Anti-Inflammatory Cytokines in Wistar Rats Subjected to Immobilization Stress and Treated with Tuftsin-Pro-Gly-Pro Peptide. 接受固定应激和 Tuftsin-Pro-Gly-Pro 肽治疗的 Wistar 大鼠血清中促炎症细胞因子和抗炎症细胞因子的浓度。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-20 DOI: 10.1007/s10517-024-06273-y

M S Krivoshlykova, I I Bobyntsev, A O Vorvul, O A Medvedeva, Iu E Azarova

引用次数: 0