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Evaluation of the Role of Glucagon-Like Peptide-1 Receptors in the Infarction-Limiting and Inotropic Effects of Adaptation to Chronic Hypoxia in Rats with and without Metabolic Syndrome. 胰高血糖素样肽-1受体在有和无代谢综合征大鼠慢性缺氧适应的梗死限制和肌力作用中的作用评价。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-09-30 DOI: 10.1007/s10517-026-06744-4
N S Voronkov, N V Naryzhnaya, B K Kurbatov, V R Latonov, L N Maslov
{"title":"Evaluation of the Role of Glucagon-Like Peptide-1 Receptors in the Infarction-Limiting and Inotropic Effects of Adaptation to Chronic Hypoxia in Rats with and without Metabolic Syndrome.","authors":"N S Voronkov, N V Naryzhnaya, B K Kurbatov, V R Latonov, L N Maslov","doi":"10.1007/s10517-026-06744-4","DOIUrl":"https://doi.org/10.1007/s10517-026-06744-4","url":null,"abstract":"<p><p>We studied the involvement of glucagon-like peptide-1 receptors (GLP-1R) in mediating the infarct-limiting and inotropic effects of adaptation to chronic continuous hypoxia (CCH) in rats with normal metabolism and animals with diet-induced metabolic syndrome (MetS). CCH was modeled by housing rats in a hypoxic chamber (12% O<sub>2</sub>) continuously for 21 days. Acute myocardial ischemia/reperfusion was modeled by ligation of the left coronary artery for 45 min followed by reperfusion for 120 min. CCH resulted in a 44% reduction in infarct size during ischemia/reperfusion and improved myocardial contractility during reperfusion relative to the control group. MetS impaired the infarct-limiting and positive inotropic effects of CCH. Administration of the GLP-1R antagonist, exendin(9-39), at a dose of 50 μg/kg before modeling coronary occlusion had no effect on infarct size and cardiac contractility in rats adapted to CCH, in rats with MetS, or in rats adapted to CCH against the background of MetS. These results suggest that the GLP-1R is not involved in the infarct-limiting and positive inotropic effects of adaptation to CCH.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biocompatibility, Tissue Integration, and Angiogenic Potential of Polylactic Acid-Based Scaffolds in the Chicken Embryo Chorioallantoic Membrane Model. 聚乳酸基支架在鸡胚绒毛尿囊膜模型中的生物相容性、组织整合和血管生成潜力。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-26 DOI: 10.1007/s10517-026-06737-3
A A Golubeva, A D Tsareva, I V Kholodenko, D V Klinov, D A Ivanov, P V Belousov, K N Yarygin
{"title":"Biocompatibility, Tissue Integration, and Angiogenic Potential of Polylactic Acid-Based Scaffolds in the Chicken Embryo Chorioallantoic Membrane Model.","authors":"A A Golubeva, A D Tsareva, I V Kholodenko, D V Klinov, D A Ivanov, P V Belousov, K N Yarygin","doi":"10.1007/s10517-026-06737-3","DOIUrl":"10.1007/s10517-026-06737-3","url":null,"abstract":"<p><p>The use of stem cells for the treatment of chronic wounds and burns is a promising trend in regenerative medicine. The efficacy of this approach largely depends on the cell delivery strategy. It is established that the use of polymeric scaffolds as cell carriers can, under certain conditions, facilitate integration of the graft into the host tissues and induce angiogenesis. We demonstrated that porous polylactide scaffolds induce pronounced perifocal vascularization with a minimal inflammatory response and the absence of fibrosis in the chorioallantoic membrane (CAM) model. Composite PLA/PCL structures additionally provide partial vascular ingrowth into the scaffold. At the same time, smooth PLA fibers demonstrated limited pro-angiogenic activity and induced perifocal fibrosis. Thus, matrix architecture is a crucial determinant of pro-angiogenic and general tissue responses, while porous scaffolds seem to be the most suitable for cell therapy of chronic wounds and burns.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"126-131"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver Structure after Administration of Autophagy-Modifying Drugs in Mice with Experimental Skin Melanoma. 自噬修饰药物对实验性皮肤黑色素瘤小鼠肝脏结构的影响。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06728-4
E A Telpukhovskaia, M A Karpov, N P Bgatova, V V Klimontov, Iu S Taskaeva
{"title":"Liver Structure after Administration of Autophagy-Modifying Drugs in Mice with Experimental Skin Melanoma.","authors":"E A Telpukhovskaia, M A Karpov, N P Bgatova, V V Klimontov, Iu S Taskaeva","doi":"10.1007/s10517-026-06728-4","DOIUrl":"10.1007/s10517-026-06728-4","url":null,"abstract":"<p><p>Morphological changes in the liver were evaluated in mice with implanted B16 skin melanoma after chloroquine and lithium carbonate administration. In mice treated with lithium carbonate, lower volume and numerical densities of degenerative and necrotic lesions were revealed. In mice treated with chloroquine, the number of degenerative and necrotic changes did not differ from that in the pathological control group (mice with tumors). The numerical density of binucleated hepatocytes was higher in the chloroquine-treated group. In tumor-bearing mice treated with either chloroquine or lithium, collagen deposits were detected in the portal triads. The administration of autophagy inducer lithium carbonate promoted intracellular regeneration of hepatocytes. Chloroquine, a well-known autophagy blocker, did not affect the development of hepatocyte degeneration and necrosis, but stimulated the cell regeneration. Collagen deposits were found in all studied groups.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"69-72"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Effects of Nicorandil and Sodium Nitroprusside on the Progression of Microvascular Obstruction in the Myocardial Infarction Zone in Rats. 尼可地尔与硝普钠对大鼠心肌梗死区微血管阻塞进展影响的比较。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-23 DOI: 10.1007/s10517-026-06722-w
D L Sonin, M S Medved, G V Papayan, D A Mochalov, S M Minasian, M M Galagudza
{"title":"Comparison of the Effects of Nicorandil and Sodium Nitroprusside on the Progression of Microvascular Obstruction in the Myocardial Infarction Zone in Rats.","authors":"D L Sonin, M S Medved, G V Papayan, D A Mochalov, S M Minasian, M M Galagudza","doi":"10.1007/s10517-026-06722-w","DOIUrl":"10.1007/s10517-026-06722-w","url":null,"abstract":"<p><p>Recent studies have shown that exogenous nitric oxide alleviates tissue injury caused by ischemia and reperfusion. The multitarget drug nicorandil possessing a dual mechanism of action combining the release of nitric oxide with opening of ATP-dependent K channels seems promising. We studied the infarction-limiting effect of nicorandil and its impact on the progression of the no-reflow/slow flow phenomenon in the myocardial infarction zone in rats compared to sodium nitroprusside. In a rat in vivo model of regional myocardial ischemia and reperfusion, neither nicorandil nor sodium nitroprusside reduced myocardial infarction size in rats with early no-reflow. Despite the dual mechanism of action of nicorandil (0.2 mg/kg), sodium nitroprusside (60 μg/kg) was more effective in reducing the size of the early no-reflow zone, and a trend toward a decrease in the no-reflow zone was observed at the end of 2‑h reperfusion.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"32-39"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory Mediators during the Stages of Remission Development in Alcohol Dependence. 酒精依赖缓解发展阶段的炎症介质
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06725-7
E V Epimakhova, T P Vetlugina, I V Voevodin, V D Prokopieva, N A Bokhan
{"title":"Inflammatory Mediators during the Stages of Remission Development in Alcohol Dependence.","authors":"E V Epimakhova, T P Vetlugina, I V Voevodin, V D Prokopieva, N A Bokhan","doi":"10.1007/s10517-026-06725-7","DOIUrl":"10.1007/s10517-026-06725-7","url":null,"abstract":"<p><p>We studied the dynamics of peripheral inflammatory mediators (LPS, LPS-binding protein, and proinflammatory cytokines TNFα and IL‑8) in the blood serum of men with alcohol dependence at the stages of withdrawal syndrome: on days 2‑3 of alcohol withdrawal, after standard 14‑17-day therapy, and during remission several months after hospital discharge, with assessment of patient's clinical status. A significant increase in the levels of inflammatory markers compared to the control group (apparently healthy men) was observed during the withdrawal syndrome followed by a decrease in these parameters (except for chemokine IL‑8) after therapy and during remission. Correlations between the levels of inflammatory mediators and alcohol craving scores (measured using the Pennsylvania Alcohol Craving Scale) were found during therapy and in remission.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"53-56"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: RSF-1/hSNF2H Promotes the Proliferation and Migration of Adenoid Cystic Cancer Cells. 校正：RSF-1/hSNF2H促进腺样囊性癌细胞的增殖和迁移。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 DOI: 10.1007/s10517-026-06743-5
Xiaorong Wang, Aichao Gao, Xingdong Liu, Zhe Yang
{"title":"Correction to: RSF-1/hSNF2H Promotes the Proliferation and Migration of Adenoid Cystic Cancer Cells.","authors":"Xiaorong Wang, Aichao Gao, Xingdong Liu, Zhe Yang","doi":"10.1007/s10517-026-06743-5","DOIUrl":"10.1007/s10517-026-06743-5","url":null,"abstract":"","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"172"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of Human Cells with Monoallelic Expression of HLA‑A in HLA Class I Knockout Cells for Evaluation of Antigen Presentation. 在HLA I类敲除细胞中产生单等位基因表达HLA - A的人细胞用于抗原呈递的评估。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-28 DOI: 10.1007/s10517-026-06739-1
U Boyarskikh, A Serych, E Khrapov, D Shamovskaya, M Filipenko
{"title":"Generation of Human Cells with Monoallelic Expression of HLA‑A in HLA Class I Knockout Cells for Evaluation of Antigen Presentation.","authors":"U Boyarskikh, A Serych, E Khrapov, D Shamovskaya, M Filipenko","doi":"10.1007/s10517-026-06739-1","DOIUrl":"10.1007/s10517-026-06739-1","url":null,"abstract":"<p><p>Cells expressing monoallelic HLA class I molecules represent a convenient in vitro model for studying the immunogenicity of tumor protein neoepitopes. Such models can be generated using endogenous HLA class I-deficient cells. Here, we describe an effective method for eliminating HLA class I expression in HEK293T cells via simultaneous CRISPR/Cas9 editing of the HLA‑A, HLA‑B, and HLA‑C genes using a single guide RNA. An important advantage of this method is the possibility to maintain the unedited HLA‑E gene. The antigen-presenting function of the resulting cells was successfully restored by transduction of a single HLA class I allele. Cells expressing monoallelic HLA‑A, after processing SARS-CoV‑2 epitopes, induced the allele-specific immune response in leukocytes isolated from patients who had recovered from COVID-19. Thus, the obtained HLA class I-knockout cells can be used to evaluate allele-specific neoantigen presentation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"140-147"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Shift of NLRP3 Inflammasome Activity in Aged Macrophages. 老龄巨噬细胞NLRP3炎性体活性的功能改变。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-28 DOI: 10.1007/s10517-026-06742-6
A V Blagova, A Satish, A K Berdnikov, S V Novikova, N A Rozanova, V S Voronina, N A Kolotieva, Y K Komleva, A B Salmina
{"title":"Functional Shift of NLRP3 Inflammasome Activity in Aged Macrophages.","authors":"A V Blagova, A Satish, A K Berdnikov, S V Novikova, N A Rozanova, V S Voronina, N A Kolotieva, Y K Komleva, A B Salmina","doi":"10.1007/s10517-026-06742-6","DOIUrl":"10.1007/s10517-026-06742-6","url":null,"abstract":"<p><p>The present study investigates the functional remodeling of the NLRP3 inflammasome in bone marrow-derived macrophages during aging. Upon LPS stimulation, no increase in proinflammatory cytokine secretion was detected; however, NLRP3 activation was accompanied by an increase in DNA fragmentation. Pharmacological inhibition of the inflammasome with MCC950 attenuated apoptosis while simultaneously increasing the proportion of senescent cells, indicating a shift from apoptosis toward senescence. These findings suggest a functional shift in NLRP3 activity during aging: rather than playing a predominantly proinflammatory role, it participates in the regulation of the balance between apoptosis, senescence, and cell survival. This highlights the need for a cautious approach to the therapeutic inhibition of NLRP3 in age-associated pathologies.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"164-171"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of Vascular Organoids from Human iPSCs to Study Neurodegenerative Processes. 利用人多能干细胞生成血管类器官研究神经退行性过程。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-26 DOI: 10.1007/s10517-026-06736-4
D A Lifanov, E S Perepelitsa, A A Kopylova, A V Blagova, K O Salina, A Satish, S O Yurchenko, A B Salmina, S N Illarioshkin
{"title":"Generation of Vascular Organoids from Human iPSCs to Study Neurodegenerative Processes.","authors":"D A Lifanov, E S Perepelitsa, A A Kopylova, A V Blagova, K O Salina, A Satish, S O Yurchenko, A B Salmina, S N Illarioshkin","doi":"10.1007/s10517-026-06736-4","DOIUrl":"10.1007/s10517-026-06736-4","url":null,"abstract":"<p><p>Organoids are a type of three-dimensional cellular constructs comprising cells of various specializations (phenotypes). In contrast to simple cellular spheroids (aggregates), cells within organoids exhibit more complex differentiation and functional characteristics. This study describes a protocol for generating vascular organoids incorporating vascular endothelial cells. A step-by-step workflow is presented, detailing the necessary reagents and consumables. Additionally, a method for validating differentiation outcomes using immunofluorescence staining is described. Morphological differences are reported between organoids derived from stem cells of a healthy donor and those from patients with Alzheimer's or Parkinson's disease.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"116-125"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal Activity Rapidly Decreases the Level of p53 Protein in Rat Hippocampus In Vivo. 神经元活动迅速降低大鼠海马p53蛋白水平。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-21 DOI: 10.1007/s10517-026-06716-8
P D Lisachev, M B Shtark
{"title":"Neuronal Activity Rapidly Decreases the Level of p53 Protein in Rat Hippocampus In Vivo.","authors":"P D Lisachev, M B Shtark","doi":"10.1007/s10517-026-06716-8","DOIUrl":"10.1007/s10517-026-06716-8","url":null,"abstract":"<p><p>It was previously shown that the induction of long-term post-tetanic potentiation of synaptic transmission in rat hippocampal slices is accompanied by a rapid decrease in the levels of the transcription factor p53 (tumor suppressor p53). However, it remained unclear whether a similar phenomenon could be observed in vivo. To answer this question, we employed a pentylenetetrazole (PTZ)-induced seizure model in rats. At 20 and 40 min after an intraperitoneal injection of PTZ, hippocampal p53 levels were significantly reduced compared to the intact controls. These findings validate the data previously obtained in vitro.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"1-3"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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