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Investigation of Structural Peculiarities of Smooth Muscle Titin Aggregates, Formed under Different In Vitro Conditions, by Small-Angle X-Ray Scattering and Fourier Transform Infrared Spectroscopy 用小角 X 射线散射和傅立叶变换红外光谱法研究在不同体外条件下形成的平滑肌 Titin 聚集体的结构特异性
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06207-8
M. A. Timchenko, A. A. Timchenko, A. S. Kazakov, I. M. Vikhlyantsev, L. G. Bobyleva, A. G. Bobylev
{"title":"Investigation of Structural Peculiarities of Smooth Muscle Titin Aggregates, Formed under Different In Vitro Conditions, by Small-Angle X-Ray Scattering and Fourier Transform Infrared Spectroscopy","authors":"M. A. Timchenko, A. A. Timchenko, A. S. Kazakov, I. M. Vikhlyantsev, L. G. Bobyleva, A. G. Bobylev","doi":"10.1007/s10517-024-06207-8","DOIUrl":"https://doi.org/10.1007/s10517-024-06207-8","url":null,"abstract":"<p>Small-angle X-ray scattering (SAXS) and Fourier transform infrared (FTIR) spectroscopy were used to investigate structural peculiarities of two types of amyloid aggregates of smooth muscle titin, which differed in their morphology and ability to disaggregate, and differently bound thioflavin T dye. SAXS showed that the structure/shape of the two titin aggregate types was close to a flat shape. FTIR spectroscopy revealed no differences in the secondary structure of the two types. These data suggest that both types of “flat-shape” titin aggregates are identical in their secondary structure and, as shown previously, have a quaternary cross-β structure. An assumption was made that the most stable supramolecular complexes of a cross-β structure, which do not differ in their secondary structure, formed first during the aggregation of smooth muscle titin. Then, depending on ambient conditions, these supramolecular structures could form titin aggregates of different morphology and properties.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocytosis of Synaptic Vesicle in Motor Nerve Endings of FUS Transgenic Mice with a Model of Amyotrophic Lateral Sclerosis 肌萎缩侧索硬化症模型 FUS 转基因小鼠运动神经末梢突触小泡的内吞作用
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06206-9
P. N. Grigoryev, G. A. Gaptrakhmanova, A. A. Plotnikova, A. L. Zefirov, M. A. Mukhamedyarov
{"title":"Endocytosis of Synaptic Vesicle in Motor Nerve Endings of FUS Transgenic Mice with a Model of Amyotrophic Lateral Sclerosis","authors":"P. N. Grigoryev, G. A. Gaptrakhmanova, A. A. Plotnikova, A. L. Zefirov, M. A. Mukhamedyarov","doi":"10.1007/s10517-024-06206-9","DOIUrl":"https://doi.org/10.1007/s10517-024-06206-9","url":null,"abstract":"<p>In experiments on the motor nerve endings of the diaphragm of transgenic FUS mice with a model of amyotrophic lateral sclerosis at the pre-symptomatic stage of the disease, the processes of transmitter release and endocytosis of synaptic vesicles were studied. In FUS mice, the intensity of transmitter release during high-frequency stimulation of the motor nerve (50 imp/sec) was lowered. At the same duration of stimulation, the loading of fluorescent dye FM1-43 was lower in FUS mice. However, at the time of stimulation, during which an equal number of quanta are released in wild-type and FUS mice, no differences in the intensity of dye loading were found. Thus, endocytosis is not the key factor in the mechanism of synaptic dysfunction in FUS mice at the pre-symptomatic stage.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anxiolytic Action of Dipeptide Mimetic of the BDNF Loop 2 in Adult Animals 二肽模拟 BDNF 环路 2 对成年动物的抗焦虑作用
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06208-7
L. G. Kolik, A. V. Nadorova, E. M. Grigorevskikh, N. M. Sazonova, T. A. Gudasheva
{"title":"Anxiolytic Action of Dipeptide Mimetic of the BDNF Loop 2 in Adult Animals","authors":"L. G. Kolik, A. V. Nadorova, E. M. Grigorevskikh, N. M. Sazonova, T. A. Gudasheva","doi":"10.1007/s10517-024-06208-7","DOIUrl":"https://doi.org/10.1007/s10517-024-06208-7","url":null,"abstract":"<p>We studied the anti-anxiety effect of a low-molecular-weight mimetic of the BDNF loop 2, hexamethylenediamide bis-(-N-hexanoyl-L-seryl-L-lysine) (GTS-201) in adult animals. GTS-201 at a dose of 5 mg/kg after acute intraperitoneal administration to outbred male and female rats increased the time spent in the open arms and the number of entries into the open arms in the elevated plus maze (EPM). In “highly emotional” male BALB/c mice, GTS-201 exhibited a dose-dependent anxiolytic effect in the EPM in a dose range of 0.5-2.0 mg/kg with a maximum effective dose of 1 mg/kg. These data confirm the previously revealed anti-anxiety properties of GTS-201 in inbred male and female BALB/c mice and rats and indicate the dependence of the pharmacological activity of the BDNF mimetic on animal age.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Method for Predicting Ultradian Body Temperature Rhythms in Small Animals 预测小动物昼夜体温节律的方法
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-12 DOI: 10.1007/s10517-024-06216-7
M. E. Diatroptov, M. A. Diatroptova
{"title":"A Method for Predicting Ultradian Body Temperature Rhythms in Small Animals","authors":"M. E. Diatroptov, M. A. Diatroptova","doi":"10.1007/s10517-024-06216-7","DOIUrl":"https://doi.org/10.1007/s10517-024-06216-7","url":null,"abstract":"<p>It has been found that the intraday dynamics of body temperature in small mammal and bird species on the adjacent day are similar. Therefore, by focusing on the body temperature dynamics of the previous day, it is possible to predict with a high degree of accuracy the periods of increase and decrease in body temperature for the current day. This phenomenon was observed when animals were kept under natural illumination and under artificial illumination when the phase of the intrinsic circadian rhythm shifted by 1-2 h every day. When analyzing this phenomenon in birds, it has been shown that the best match for body temperature dynamics occurs when comparing adjacent days based on sidereal days (a period of 23 h and 56 min). Over time, after several days, the daily patterns of body temperature fluctuation take on a completely different form and frequency. These facts suggest a connection between ultradian rhythms and the rotation of the Earth around its axis, and consequently, the position of animals on the surface of the planet relative to space objects.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous and Stimulated Production of Cytokines by Blood Cells Ex Vivo as a Biomarker of Initially High or Low Hypoxia Resistance in Rats 大鼠体内血细胞自发和受刺激产生的细胞因子是初期耐缺氧能力高低的生物标志物
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-11 DOI: 10.1007/s10517-024-06200-1
D. Sh. Dzhalilova, A. M. Kosyreva, O. V. Makarova
{"title":"Spontaneous and Stimulated Production of Cytokines by Blood Cells Ex Vivo as a Biomarker of Initially High or Low Hypoxia Resistance in Rats","authors":"D. Sh. Dzhalilova, A. M. Kosyreva, O. V. Makarova","doi":"10.1007/s10517-024-06200-1","DOIUrl":"https://doi.org/10.1007/s10517-024-06200-1","url":null,"abstract":"<p>Spontaneous and stimulated production of cytokines by peripheral blood cells obtained from the caudal vein of male Wistar rats was assessed before testing their resistance to oxygen deficiency in a decompression chamber. To study the spontaneous production of cytokines, heparinized blood cells were incubated in a culture medium (24 h, 5% CO<sub>2</sub>, 37°C) and the content of proinflammatory cytokines IL-6 and TNFα and anti-inflammatory IL-10 in the culture medium was assessed by ELISA. To stimulate cytokine production, blood cells were incubated for 24 h with LPS, phytohemagglutinin, and concanavalin A at final concentrations of 2, 4, and 4 μg, respectively. Two weeks after blood sampling, individual resistance of the animals to hypoxia in a decompression chamber was determined. In animals with low resistance to hypoxia, the levels of spontaneous production of all three cytokines were significantly higher, while after stimulation, the level of IL-1β increased by more than 2 times. The animals with spontaneous production of IL-10&gt;50 pg/ml, IL-6&gt;10 pg/ml, and TNFα&gt;10 pg/ml, as well as with the increase in IL-1β production by more than 2 times upon stimulation were classified as low-resistant. At IL-10&lt;15 pg/ml, IL-6&lt;9 pg/ml, and TNFα&lt;7 pg/ml, as well as the absence of the increase in IL-1β production upon stimulation, they were classified as high-resistant. The identified features of spontaneous and stimulated production of cytokines can be used as non-invasive biomarkers to determine the resistance to hypoxia without exposure to sublethal hypoxia in a decompression chamber.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Peripheral Neuropathy in Rat Models of Metabolic Syndrome and Diabetes Mellitus 评估代谢综合征和糖尿病大鼠模型中的周围神经病变
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-11 DOI: 10.1007/s10517-024-06198-6
E. V. Ivanov, M. R. Akhmetshina, A. R. Gizatulina, S. A. Gavrilova
{"title":"Evaluation of Peripheral Neuropathy in Rat Models of Metabolic Syndrome and Diabetes Mellitus","authors":"E. V. Ivanov, M. R. Akhmetshina, A. R. Gizatulina, S. A. Gavrilova","doi":"10.1007/s10517-024-06198-6","DOIUrl":"https://doi.org/10.1007/s10517-024-06198-6","url":null,"abstract":"<p>The dynamics of nephropathy development in rats with type 2 diabetes mellitus, caused by a high-fat diet and the streptozotocin administration (25 mg/kg), and metabolic syndrome, caused by addition of 20% fructose solution to the diet, was evaluated during the experiment. Models with moderate severity of metabolic changes without significant changes in body weight were obtained after 24 weeks. To study neuropathy severity, the method of electroneuromyography was used; the velocities of motor and sensory excitation propagation along the caudal nerve fibers were measured. In modeled diabetes mellitus against the background of hyperglycemia, a marked decrease in motor and sensory propagation rates was observed, and an increase in the response durations was noted from week 12 to week 24, indicating pronounced neuropathy. In the fructose model, the motor response duration increased from week 12, which possibly indicates the development of peripheral neuropathy.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histone H3K9 Methylation Features under Hypoxic Conditions after the HIF1A Knockdown in Mesenchymal Stromal Cells In Vitro 间充质基质细胞体外敲除 HIF1A 后缺氧条件下组蛋白 H3K9 甲基化的特征
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-11 DOI: 10.1007/s10517-024-06203-y
P. I. Bobyleva, E. A. Tyrina, M. V. Lobanova, L. B. Buravkova
{"title":"Histone H3K9 Methylation Features under Hypoxic Conditions after the HIF1A Knockdown in Mesenchymal Stromal Cells In Vitro","authors":"P. I. Bobyleva, E. A. Tyrina, M. V. Lobanova, L. B. Buravkova","doi":"10.1007/s10517-024-06203-y","DOIUrl":"https://doi.org/10.1007/s10517-024-06203-y","url":null,"abstract":"<p>The effects of <i>HIF1A</i> knockdown by RNA interference on the histone H3K9 methylation in human umbilical cord mesenchymal stromal cells <i>in vitro</i> under conditions of 24-h exposure to hypoxia (1% O<sub>2</sub>) were studied. Evaluation of transcriptional activity of genes involved in the regulation of H3K9 methylation (<i>KDM3A, KDM4A,</i> and <i>EHMT2</i>) and the cytofluorimetric analysis of the expression of the corresponding antigens and H3K9 methylation level demonstrated a pronounced stimulating effect of hypoxic exposure. Moreover, the expression of <i>KDM4A</i> and <i>EHMT2</i> was regulated by <i>HIF1A</i>-mediated mechanism, unlike <i>KDM3A;</i> the level of the corresponding proteins depended on HIF1A. In addition, the HIF-1-dependent regulation of KDM3A, KDM4A, and EHMT2/G9a, and directly the H3K9 methylation level in mesenchymal stromal cells also took place under normoxia conditions.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Anticholinesterase Drugs on Activity and Properties of Na+,K+-ATPase in Rat Erythrocytes under Stress Caused by Intense Physical Exercise 抗胆碱酯酶药物对剧烈运动应激下大鼠红细胞 Na+、K+-ATP 酶活性和特性的影响
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-11 DOI: 10.1007/s10517-024-06202-z
V. N. Dubrovskii, K. Yu. Maslakova, E. A. Savchenko
{"title":"Influence of Anticholinesterase Drugs on Activity and Properties of Na+,K+-ATPase in Rat Erythrocytes under Stress Caused by Intense Physical Exercise","authors":"V. N. Dubrovskii, K. Yu. Maslakova, E. A. Savchenko","doi":"10.1007/s10517-024-06202-z","DOIUrl":"https://doi.org/10.1007/s10517-024-06202-z","url":null,"abstract":"<p>We studied the effect of intramuscular injection of physostigmine and neostigmine on Na<sup>+</sup>,K<sup>+</sup>-ATPase activity in erythrocytes of rats subjected to intense physical exercise. Both anticholinesterase drugs had a significant effect on the development of the stress response, which was expressed in a decrease in the manifestation of its individual components such as the concentration of ascorbic acid in the adrenal glands, stress-related erythrocyte polycythemia, and LPO indicators. Anticholinesterase drugs reverse the stress-induced decrease in Na<sup>+</sup>,K<sup>+</sup>-ATPase activity, as well as changes in its magnesium-dependent properties. There were no changes in the activity of the studied enzyme in the erythrocyte ghosts. We associate the observed differences with the correction of the functions of the cholinergic components of the hypothalamic—pituitary—adrenal axis leading to the development of a hypoergic type stress reaction.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the Dynamics of Cognitive Impairments and Expression of Caspase Cascade Genes in Preclinical Stages of Parkinsonism Modeled Using α-Synuclein Oligomers 使用α-突触核蛋白寡聚体模拟帕金森病临床前阶段认知障碍和Caspase级联基因表达的动态分析
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-11 DOI: 10.1007/s10517-024-06199-5
M. A. Gruden, V. I. Inokenteva, O. A. Solovieva, N. P. Mikhailova, A. M. Ratmirov, V. V. Sherstnev, Z. I. Storozheva
{"title":"Analysis of the Dynamics of Cognitive Impairments and Expression of Caspase Cascade Genes in Preclinical Stages of Parkinsonism Modeled Using α-Synuclein Oligomers","authors":"M. A. Gruden, V. I. Inokenteva, O. A. Solovieva, N. P. Mikhailova, A. M. Ratmirov, V. V. Sherstnev, Z. I. Storozheva","doi":"10.1007/s10517-024-06199-5","DOIUrl":"https://doi.org/10.1007/s10517-024-06199-5","url":null,"abstract":"<p>The behavioral effects of α-synuclein oligomers were studied at various times after its chronic intranasal administration to 75-day-old C57BL/6J mice in comparison with the dynamics of changes in the transcriptional activity of caspases genes (<i>Casp9</i>, <i>Casp8</i>, and <i>Casp3</i>) in the hippocampus, frontal cortex, and cerebellum. The negative effects of α-synuclein oligomers on exploratory activity and short-term memory in the novel object recognition test were most pronounced after 90 days from the end of administration, while after 1 and 270 days, partial compensation of the studied cognitive functions was observed. Analysis of the expression of caspase genes suggests that early compensatory mechanisms are associated with suppression of the effector caspase-3 gene expression along with increased activity of the genes encoding initiator caspases-9 and -8. Late compensation processes are associated with a decrease in the activity of initiator caspases in the frontal cortex and cerebellum.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Level of Markers Stimulating Growth Factor 2 (ST2), N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP), and D-Dimer in Healthy Volunteer Testers in 21-Day Head-Down -6° Tilt Bed Rest as a Model of Hypodynamia 作为低动力状态模型的 21 天低头-6°倾斜卧床休息中健康志愿者测试者体内刺激生长因子 2 (ST2)、脑钠肽 N 端前体 (NT-proBNP) 和 D-Dimer 的标志物水平
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-11 DOI: 10.1007/s10517-024-06197-7
O. V. Popova, D. N. Kashirina, L. Kh. Pastushkova, A. G. Goncharova, I. M. Larina
{"title":"The Level of Markers Stimulating Growth Factor 2 (ST2), N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP), and D-Dimer in Healthy Volunteer Testers in 21-Day Head-Down -6° Tilt Bed Rest as a Model of Hypodynamia","authors":"O. V. Popova, D. N. Kashirina, L. Kh. Pastushkova, A. G. Goncharova, I. M. Larina","doi":"10.1007/s10517-024-06197-7","DOIUrl":"https://doi.org/10.1007/s10517-024-06197-7","url":null,"abstract":"<p>The paper presents an analysis of the proteomic composition in relation to both the risk of thrombosis and changes in the state of cardiomyocytes associated with the risk of cardiac fibrosis and heart failure. We examined 12 practically healthy male volunteers exposed to head-down -6° tilt bed rest (HDBR) for 21 days. The revealed decrease in the level of stimulating growth factor 2 (ST2) on days 10 and 21 relative to the initial values (background; 5 days before HDBR) indicated a decrease in the myocardial load and cardiomyocyte extensibility. The level of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) increased on day 2, decreased on days 10 and 21 of HDBR relative to the background levels, and returned to baseline values after the recovery period (5 days after HDBR). The revealed changes in the level of NT-proBNP reflected the increase in circulating blood volume corresponding to HDBR duration and the role of the gravity component in increasing the functional load on the myocardium. Unchanged blood level of D-dimer at all points of the study indicates that there is no risk of thrombosis under the conditions of this study.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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