分级伽玛辐射后大理岩掩埋试验中小鼠行为变化的动力学研究。

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-29 DOI:10.1007/s10517-025-06467-y

N I Atamanyuk

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引用次数: 0

摘要

我们研究了出生后第一个月的累积剂量为0.1、1和5 Gy的分段γ射线照射对C57BL/6小鼠早期和后期焦虑行为指标的影响。用大理石掩埋试验评价焦虑程度。持续的剂量依赖性行为改变被发现：0.1 Gy剂量的辐射导致1和6个月大的焦虑水平增加，而5 Gy剂量的辐射抑制了动物在大理石掩埋试验中的活动，直到12个月大。1 Gy剂量的辐照仅在辐照后延迟期降低焦虑参数。

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The Dynamics of Radiation-Induced Changes in Mice Behavior in the Marble Burying Test after Fractionated Gamma Irradiation.

We studied the effect of fractionated gamma irradiation at cumulative doses of 0.1, 1, and 5 Gy during the first month of life on the indices of anxious behavior in C57BL/6 mice in the early and delayed terms after the exposure. Anxiety was evaluated using the marble burying test. Persistent dose-dependent behavioral changes were revealed: irradiation at a dose of 0.1 Gy led to an increase in the anxiety level at the age of 1 and 6 months, whereas exposure at a dose of 5 Gy suppressed animal activity in the marble burying test until the age of 12 months. Irradiation at a dose of 1 Gy decreased anxiety parameters only in the delayed period after the irradiation.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.