Bulletin of Experimental Biology and Medicine最新文献

Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats. 胸腺原类似物对联氨性肝病大鼠的保肝作用。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-29 DOI: 10.1007/s10517-025-06405-y

A A Chulanova, A M Smakhtina, G S Mal, I I Bobyntsev, M Yu Smakhtin, E S Mishina, P M Kopeykin, E G Bogomolova

引用次数: 0

Analysis of Specific MicroRNAs Expressed after Intake of Cobalt and Xenon Preparations for Anti-Doping Control. 用于反兴奋剂控制的钴和氙制剂摄入后表达的特异性microrna分析。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-29 DOI: 10.1007/s10517-025-06406-x

P V Postnikov, I V Pronina, D S Polyansky, Yu A Efimova, Z G Ordzhonikidze, V A Badtieva, D B Nikityuk

引用次数: 0

Effect of X-Ray Energy on the Quantitative Yield of γH2AX and 53BP1 Foci in Human Mesenchymal Stem Cells. x射线能量对人间充质干细胞γ - h2ax和53BP1病灶定量产量的影响

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-29 DOI: 10.1007/s10517-025-06404-z

M A Ignatov, A K Chigasova, A A Osipov, Yu A Fedotov, N Yu Vorobyeva, A N Osipov

引用次数: 0

Metagenomic Analysis of Caseum of Tuberculosis Foci. 结核疫源地病例的宏基因组分析。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI: 10.1007/s10517-025-06384-0

E A Orlova, V V Sinkov, O B Ogarkov, A E Suzdalnitsky, I G Kondratov, S N Zhdanova, L V Rychkova, L I Kolesnikova

{"title":"Metagenomic Analysis of Caseum of Tuberculosis Foci.","authors":"E A Orlova, V V Sinkov, O B Ogarkov, A E Suzdalnitsky, I G Kondratov, S N Zhdanova, L V Rychkova, L I Kolesnikova","doi":"10.1007/s10517-025-06384-0","DOIUrl":"https://doi.org/10.1007/s10517-025-06384-0","url":null,"abstract":"The microbiota of the deep lung regions significantly differs from that of the upper respiratory tract by much lower biomass and dynamic diversity. In our previous studies we found that the biodiversity of the satellite microbiota of tuberculosis foci is sharply reduced in comparison with intact lung tissues. These findings allowed us to classify microbial communities in the caseous necrosis of tuberculomas into two types: (i) mycobacterial caseoma (tuberculoma), where 70% or more of the genomes correspond to Mycobacterium tuberculosis, and (ii) a polymicrobial community, where the concentration of M. tuberculosis varies from 0 to 10%. Using shotgun metagenomic sequencing, 14 tuberculomas from 13 patients were analyzed on a NextSeq 550 platform (Illumina). Taxonomic classification of short reads was performed using Kraken 2. The results show that, on average, 99.95% of the short reads belonged to human DNA or were unclassified. However, the classified reads related to bacterial genomes confirmed the concept that in many cases, tuberculomas contained polymicrobial communities that either replaced or supplemented the original mycobacterial microbiota of the caseous material.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"610-614"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Markers of Abnormal Placental Attachment in Pregnant Women. 孕妇胎盘附着异常的血清标志物。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI: 10.1007/s10517-025-06397-9

K A Artemyeva, I A Kulikov, N V Nizyaeva, I I Stepanova, N B Tikhonova, L M Mikhaleva

引用次数: 0

Pulmonary Arterial Hypertension Induces Compensatory Increase of Left Ventricular Contractility Indexes in Rats in Response to Its Filling Insufficiency. 肺动脉高压引起大鼠左心室收缩性指数代偿性增加，以响应其充盈不足。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.1007/s10517-025-06379-x

A A Abramov, V L Lakomkin, A V Prosvirnin, V S Kuzmin

引用次数: 0

Brain-Derived Neurotrophic Factor Cancels the Cardioprotective Effect of Interleukin-2 in a Model of Systemic Inflammatory Response in Rats. 脑源性神经营养因子在大鼠全身炎症反应模型中取消白细胞介素-2的心脏保护作用。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.1007/s10517-025-06377-z

I Yu Burovenko, Yu Yu Borshchev, S M Minasyan, E S Protsak, O V Borshcheva, M M Galagudza

引用次数: 0

Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation. 有氧运动通过调节ROS释放和NLRP3炎性体激活影响淋巴细胞凋亡。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.1007/s10517-025-06398-8

X Lian, Z Guo, J Liu, W Zeng

{"title":"Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.","authors":"X Lian, Z Guo, J Liu, W Zeng","doi":"10.1007/s10517-025-06398-8","DOIUrl":"https://doi.org/10.1007/s10517-025-06398-8","url":null,"abstract":"Moderate sports training help to enhance spleen-mediated immune function, while prolonged and high-intensity physical exercises could produce an opposite effect. The specific mechanisms underlying the effects of physical load on apoptosis of splenic lymphocytes remain unclear. To address this gap, we developed a model of physical exercises in rats in order to explore the effect of intensity of these exercises on splenic lymphocyte apoptosis and its potential mechanism. We found that high-intensity exercises reduced the CD4+/CD8+ ratio, increased oxidative stress and mitochondrial membrane potential levels, activated NLRP3 inflammasomes, and promoted the expression of proapoptotic proteins, but decreased expression of anti-apoptotic proteins. In contrast, the moderate exercises produced no significant changes in ROS and mitochondrial membrane potential levels, while exerting the opposite effects on other parameters specifies in the above in comparison with the effects observed in rats subjected to intensive physical load. These results suggest that the high-intensity physical exercises promote lymphocyte apoptosis by excessive ROS release and activation of NLRP3 inflammasomes.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"685-690"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Downregulation of A20 Expression Related to T Cells by Staphylococcal Enterotoxin A Treatment. 葡萄球菌肠毒素A处理对T细胞相关A20表达下调的影响

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.1007/s10517-025-06386-y

X Chen, Y Yan, C Lin, J Yang, H Qiu

{"title":"Downregulation of A20 Expression Related to T Cells by Staphylococcal Enterotoxin A Treatment.","authors":"X Chen, Y Yan, C Lin, J Yang, H Qiu","doi":"10.1007/s10517-025-06386-y","DOIUrl":"https://doi.org/10.1007/s10517-025-06386-y","url":null,"abstract":"A20, a negative regulator of NF-κB signaling, is a potent anti-inflammatory molecule. Its deficiency is associated with a wide variety of inflammatory diseases and tumors and the ability of A20 to restrict TCR-NF-κB signaling pathway and the role of this molecule in the pathogenesis of T-cell leukemia are not completely understood. Here we studied the role of A20 in T cells exposed to staphylococcal enterotoxin A (SEA) and evaluated the results of our in vitro findings of lethal inflammation by long-term administration of SEA at low doses to Jurkat cells, human peripheral blood mononuclear cells, and CD3+ T cells. SEA treatment resulted in chronic inflammation, upregulated the expression of MALT1, IKKβ, and p65, and downregulated the expression of A20, both in dose- and time-dependent manners, in Jurkat cells, regardless of the mRNA or protein level. Thus, SEA-mediated chronic inflammation can activate TCR-NF-κB signals via the downregulation of A20 expression, which increases T-cell immortality and may promote the pathogenesis of T-cell leukemia. Modulation of A20 could be a novel strategy for the treatment of T-cell leukemia.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"619-625"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Evaluation of the Functional Potential of Mesenchymal Stem Cells from the Bichat's Fat Pad, Bone Marrow, and Adipose Tissue for Bone Tissue Regeneration. 来自Bichat脂肪垫、骨髓和脂肪组织的间充质干细胞用于骨组织再生功能潜力的比较评估。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI: 10.1007/s10517-025-06378-y

N A Bondarenko, M A Surovtseva, I I Kim, S V Ostapets, O S Kosareva, M N Drovosekov, O V Poveshchenko

引用次数: 0