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Immunohistochemical Expression of GFAP in the Brain Astrocytes of Deceased Newborns Depending on the Postmortem Interval. 死亡新生儿脑星形胶质细胞中 GFAP 的免疫组化表达取决于尸检时间间隔。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-23 DOI: 10.1007/s10517-024-06291-w
A I Shchegolev, U N Tumanova, O V Savva, G T Sukhikh
{"title":"Immunohistochemical Expression of GFAP in the Brain Astrocytes of Deceased Newborns Depending on the Postmortem Interval.","authors":"A I Shchegolev, U N Tumanova, O V Savva, G T Sukhikh","doi":"10.1007/s10517-024-06291-w","DOIUrl":"https://doi.org/10.1007/s10517-024-06291-w","url":null,"abstract":"<p><p>The changes in astrocytes and their role in the development of brain diseases can be identified by morphological analysis of tissue specimens, in particular, by immunohistochemical detection of glial fibrillary acidic protein (GFAP). The study presents analysis of GFAP expression in white matter astrocytes of deceased newborns depending on the duration of the postmortem period. Autopsy material of the brain tissue obtained from 48 deceased newborns was divided into 8 groups depending on the duration of the postmortem period. Immunohistochemical analysis was performed with antibodies to GFAP in tissue samples taken from the superior and inferior brain areas relative to the position of the body stored before autopsy. The area of GFAP+ staining per field of view was determined in the white matter using an image analysis system. Morphometric analysis revealed a decrease in the mean values of the area of GFAP+ staining, i.e. the number of fibrotic astrocytes and their processes decreased with increasing the duration of the postmortem period. The mean areas of GFAP+ staining in the superior and inferior areas of the white matter did not differ significantly between the groups. The identified changes reflect the development of nonspecific postmortem changes which should be considered when taking tissue samples for molecular biological studies and in differential forensic diagnosis with lifetime lesions and diseases.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of Myofibrils in Cardiomyocytes as a Morphological Indicator of Reduced Compensatory Capabilities of Hypertrophied Myocardium. 心肌细胞中肌原纤维的缺失是肥厚心肌补偿能力降低的形态学指标。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-23 DOI: 10.1007/s10517-024-06295-6
T V Sukhacheva, R A Serov, L A Bockeria
{"title":"Loss of Myofibrils in Cardiomyocytes as a Morphological Indicator of Reduced Compensatory Capabilities of Hypertrophied Myocardium.","authors":"T V Sukhacheva, R A Serov, L A Bockeria","doi":"10.1007/s10517-024-06295-6","DOIUrl":"https://doi.org/10.1007/s10517-024-06295-6","url":null,"abstract":"<p><p>The functioning of the ventricular myocardium in hypertrophic cardiomyopathy (HCM) under high hemodynamic load leads to depletion of its resources and is associated with the risk of developing a dilated stage. In patients with HCM, the cardiomyocytes of the interventricular septum are hypertrophied, the proportion of cardiomyocytes in which myofibrils constitute less than 50% of the sarcoplasm volume increases with increasing the cardiomyocyte length and correlates with echocardiographic signs of left ventricular obstruction. These cardiomyocytes are characterized by ultrastructural signs of synthetic activity. In the myocardium of patients with HCM, single cardiomyocytes with \"critical\" loss of myofibrils and nonspecific degenerative changes corresponding to the picture of irreversible changes in the cardiomyocyte ultrastructure were revealed. The presence of cardiomyocytes with this ultrastructural phenotype is an early marker of exhaustion of the compensatory capabilities of the myocardium in HCM.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PDX1 as a Marker of Early Differentiation of Human Pancreatic Duct Cells. 作为人类胰腺导管细胞早期分化标志物的 PDX1
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-23 DOI: 10.1007/s10517-024-06292-9
A E Proshchina, Yu S Krivova, O S Godovalova, S V Saveliev
{"title":"PDX1 as a Marker of Early Differentiation of Human Pancreatic Duct Cells.","authors":"A E Proshchina, Yu S Krivova, O S Godovalova, S V Saveliev","doi":"10.1007/s10517-024-06292-9","DOIUrl":"https://doi.org/10.1007/s10517-024-06292-9","url":null,"abstract":"<p><p>Epithelial progenitor cells of the primitive pancreatic ducts differentiate in 3 directions, which is accompanied by changes in cell phenotype. We analyze the distribution of the pancreatic and duodenal homeobox 1 (PDX1) in the epithelial cells of pancreatic ducts during the prenatal development in order to determine the potential use of this marker as an indicator of pancreatic cell maturation. Pancreatic autopsies from human fetuses (gestation weeks 17-23) were examined by immunohistochemical methods. In general, PDX1 was detected in the epithelial cells that are involved in various morphogenetic processes related to the growth and branching of the fetal pancreatic ducts. The intensive positive reaction to PDX1/cytokeratin 19 indicates immature (progenitor) polypotent ductal cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of In Vitro Low-Impulse Laser Irradiation on Morphofunctional Properties of Human Platelets. 体外低脉冲激光照射对人血小板形态功能特性的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-23 DOI: 10.1007/s10517-024-06297-4
M S Makarov, N V Borovkova, M V Storozheva, I N Ponomarev
{"title":"Effect of In Vitro Low-Impulse Laser Irradiation on Morphofunctional Properties of Human Platelets.","authors":"M S Makarov, N V Borovkova, M V Storozheva, I N Ponomarev","doi":"10.1007/s10517-024-06297-4","DOIUrl":"https://doi.org/10.1007/s10517-024-06297-4","url":null,"abstract":"<p><p>We studied morphofunctional features of human platelets exposed in vitro to low-pulse laser radiation (LPLR) with different wavelengths. Platelet-rich plasma (PRP) was irradiated at wavelengths of 635, 488, and 355 nm. LPLR with λ=635 nm and 1 W power after 10 min caused degranulation of many platelets, formation of small platelet conglomerates, and accelerated platelet adhesion on glass. LPLR with λ=635 nm and 2 mW and LPLR with λ=488 nm did not cause significant changes in the morphofunctional platelet status. LPLR with λ=355 nm induced massive platelets' deformation, sharp decrease in their morphofunctional status without activation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impaired Communication through Gap Junctions Reduces the Angiogenic Potential of the Secretome in Mesenchymal Stromal Cell-Endothelial Cell Interactions In Vitro. 间隙连接通信受损会降低间充质基质细胞-内皮细胞体外相互作用中分泌组的血管生成潜能
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-23 DOI: 10.1007/s10517-024-06296-5
M I Ezdakova, E R Andreeva
{"title":"Impaired Communication through Gap Junctions Reduces the Angiogenic Potential of the Secretome in Mesenchymal Stromal Cell-Endothelial Cell Interactions In Vitro.","authors":"M I Ezdakova, E R Andreeva","doi":"10.1007/s10517-024-06296-5","DOIUrl":"https://doi.org/10.1007/s10517-024-06296-5","url":null,"abstract":"<p><p>Highly specialized gap junctions play an important role in the interaction between endothelial (EC) and multipotent mesenchymal stromal cells (MSC). Inhibition of gap junctions with a specific inhibitor carbenoxolone attenuates the effects of the medium conditioned by MSC-EC co-culture on proliferation and migration of cultured EC. In conditioned medium from co-culture, the levels of angiogenic mediators (VEGF-A, FGF-2, MCP-1, etc.) were decreased, which apparently determines lower angiogenic effect of the conditioned medium on the growth of the vascular network in the chorioallantois membrane of quail embryo in ovo. Suppression of communication through gap junctions in associations of MSC and EC, the structural and functional units of physiological and reparative angiogenesis, can directly reduce the level of proangiogenic mediators in the microenvironment, which, in turn, can help to control the regulation of vascular function in pathologies.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Transplantation of Ensheathing Cells of the Olfactory Mucosa into the Hippocampal Area on the Restoration of Cognitive Abilities in Rats with Experimental Alzheimer's Disease. 将嗅粘膜内鞘细胞移植到海马区对恢复实验性阿尔茨海默病大鼠认知能力的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-23 DOI: 10.1007/s10517-024-06293-8
E K Karsuntseva, A D Voronova, S S Andretsova, V S Shishkina, A V Chadin, G A Fursa, A V Fedorov, I V Reshetov, O V Stepanova, V P Chekhonin
{"title":"The Effect of Transplantation of Ensheathing Cells of the Olfactory Mucosa into the Hippocampal Area on the Restoration of Cognitive Abilities in Rats with Experimental Alzheimer's Disease.","authors":"E K Karsuntseva, A D Voronova, S S Andretsova, V S Shishkina, A V Chadin, G A Fursa, A V Fedorov, I V Reshetov, O V Stepanova, V P Chekhonin","doi":"10.1007/s10517-024-06293-8","DOIUrl":"https://doi.org/10.1007/s10517-024-06293-8","url":null,"abstract":"<p><p>Alzheimer's disease was induced in female Wistar rats by bilateral injection of β-amyloid fragment 1-42 into the hippocampal region. After 8 weeks, ensheathing cells of the olfactory mucosa were transplanted into the hippocampus at the same stereotactic coordinates. These cells survived for 8 weeks; large clusters of cells were observed on week 4. On weeks 3-5 after transplantation of ensheathing cells, experimental animals demonstrated a significant cognitive improvement (memory and spatial orientation). The obtained results create prerequisites for further studies of ensheathing cells as a potential cell product for personalized therapy of Alzheimer's disease.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vitro and In Vivo Antitumor Activities of Isothiourea and Cinnamic Acid Derivative with NOS/MCT Inhibitory Effect. 具有 NOS/MCT 抑制作用的异硫脲和肉桂酸衍生物的体外和体内抗肿瘤活性
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06284-9
A A Shitova, M V Filimonova, O V Soldatova, I K Volkova, V A Rybachuk, L I Shevchenko, V I Surinova, A D Kaprin, P V Shegay, S A Ivanov, E V Shlyakhto, A S Filimonov
{"title":"In Vitro and In Vivo Antitumor Activities of Isothiourea and Cinnamic Acid Derivative with NOS/MCT Inhibitory Effect.","authors":"A A Shitova, M V Filimonova, O V Soldatova, I K Volkova, V A Rybachuk, L I Shevchenko, V I Surinova, A D Kaprin, P V Shegay, S A Ivanov, E V Shlyakhto, A S Filimonov","doi":"10.1007/s10517-024-06284-9","DOIUrl":"https://doi.org/10.1007/s10517-024-06284-9","url":null,"abstract":"<p><p>This work presents the method of synthesis and physicochemical characterization of isothiourea and cinnamic acid original derivative α-cyano-4-hydroxycinnamate 1-cyclohexanoy-l-2-ethylisothiourea (T1114). In studies of the cytotoxic and antitumor activity of T1114, it has been found that the combination in one molecular structure of NOS-inhibitory fragment (1-cyclohexanoyl-2-ethylisothiourea) and a fragment inhibiting monocarboxylate lactate transporters (MCT) (α-cyano-4-hydroxycinnamic acid) does not modify the cytotoxic activity of bifunctional NOS/MCT-inhibitor T1114 in vitro. But in vivo inhibition of NOS and MCT is able to realize effects on the tumor microenvironment and hypoxic tumor cells. Such structural and functional modification has significantly extended the antitumor activity of the new NOS/MCT inhibitor. The bifunctional compound not only realized a more pronounced antitumor effect, but also prevented the development of hypoxic adaptation in solid Ehrlich carcinoma and acquired the ability to overcome the resistance of mouse cervical cancer (RShM-5). Therefore, the combination of NOS-inhibitory, anti-vasculogenic and hypoxia-oriented toxic effects can create new opportunities in antiangiogenic therapy of malignant neoplasms.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transplantation of Cultured Mononuclear Fraction of Bone Marrow Cells in the Treatment of Heymann Nephritis in Rats. 移植培养的骨髓单核细胞治疗大鼠海曼肾炎
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06282-x
L P Sigareva, A A Kokorina, E V Mikhailova, S V Kromsky, P A Slizhov, V N Aleksandrov, R A Nasyrov
{"title":"Transplantation of Cultured Mononuclear Fraction of Bone Marrow Cells in the Treatment of Heymann Nephritis in Rats.","authors":"L P Sigareva, A A Kokorina, E V Mikhailova, S V Kromsky, P A Slizhov, V N Aleksandrov, R A Nasyrov","doi":"10.1007/s10517-024-06282-x","DOIUrl":"https://doi.org/10.1007/s10517-024-06282-x","url":null,"abstract":"<p><p>In an experiment on Wistar rats, a Heymann's active nephritis model was reproduced. After the chronic course of the disease was confirmed, we compared the effectiveness of single systemic and local transplantation of allogeneic cultured stromal cells of the mononuclear fraction of the bone marrow. Both methods of cell therapy reduced clinical manifestations of active Heymann's nephritis: proteinuria decreased and glomerular filtration rate increased 30 days after cell administration. At the histological level, signs of the inflammatory process manifested in an increase in the number of CD68<sup>+</sup> cells. Thus, in the case of autoimmune glomerulonephritis, two transplantation methods provide a comparable level of correction of functional disorders in Heymann's active nephritis model.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polymorphisms of ANPEP Gene Are Associated with Microvascular Complications of Type 2 Diabetes. ANPEP 基因的多态性与 2 型糖尿病的微血管并发症有关。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06286-7
Ya E Korvyakova, I E Azarova, D D Markina, M I Churilin, O Yu Bushueva, E Yu Klyosova, M A Solodilova, A V Polonikov
{"title":"Polymorphisms of ANPEP Gene Are Associated with Microvascular Complications of Type 2 Diabetes.","authors":"Ya E Korvyakova, I E Azarova, D D Markina, M I Churilin, O Yu Bushueva, E Yu Klyosova, M A Solodilova, A V Polonikov","doi":"10.1007/s10517-024-06286-7","DOIUrl":"https://doi.org/10.1007/s10517-024-06286-7","url":null,"abstract":"<p><p>We studied the association of polymorphisms in the aminopeptidase N gene (ANPEP) with the development of diabetic retinopathy and nephropathy in patients with type 2 diabetes mellitus (T2DM). DNA samples from T2DM patients (n=1425) were genotyped for 23 single nucleotide polymorphisms (SNPs) using the MassARRAY system. Associations of SNP rs13380049 of the ANPEP gene with a lower risk of diabetic retinopathy (OR=0.54, 95%CI 0.36-0.82, p=0.0032) and nephropathy (OR=0.66, 95%CI 0.44-0.99, p=0.048) were found in T2DM patients. In addition, SNP rs25653 was associated with retinopathy, and polymorphisms rs6496608, rs72756574, rs9920421, and rs4932143 were associated with diabetic nephropathy. The study demonstrated the contribution of ANPEP gene polymorphisms in the determination of microvascular complications in T2DM patients.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Hindlimb Unloading of Rats on Rheographic Parameters of Femoral and Brachial Arteries In Situ. 大鼠后肢卸载对股动脉和肱动脉原位流变学参数的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-22 DOI: 10.1007/s10517-024-06276-9
L N Tikhomirova, Yu S Medvedeva, M A Lebedeva, I Yu Gavrilov, S V Revenko, M Yu Karganov, E G Popov, I A Tarakanov
{"title":"The Effects of Hindlimb Unloading of Rats on Rheographic Parameters of Femoral and Brachial Arteries In Situ.","authors":"L N Tikhomirova, Yu S Medvedeva, M A Lebedeva, I Yu Gavrilov, S V Revenko, M Yu Karganov, E G Popov, I A Tarakanov","doi":"10.1007/s10517-024-06276-9","DOIUrl":"https://doi.org/10.1007/s10517-024-06276-9","url":null,"abstract":"<p><p>The rheographic parameters of the segments of brachial and femoral arteries were measured in situ after a 14-day-long hindlimb unloading (HU) of rats. HU significantly increased electrical impedance Z of a segment of femoral artery indicating its constriction; in parallel, HU resulted in a decreasing trend of Z of a segment of brachial artery attesting to its dilation. In both arteries, HU significantly or as a trend decreased the swing ranges of active and passive pulsations, respectively. BP reduction during bloodletting induced transition from passive to active pulsatile mode in the femoral artery only in 33% experimental rats in contrast to 87% control ones. We suppose that degradation of active pulsatile mode is responsible for the negative influences of microgravity and weightlessness on blood circulation. The study determined the rheographic parameters that reliably reflect changes in the functional activity of arteries after chronic redistribution of hydrostatic load.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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