Bulletin of Experimental Biology and Medicine最新文献

Aminobisphosphonates Potentiate Non-Specific Immunological Memory.

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-25 DOI: 10.1007/s10517-025-06350-w

Y Sh Schwartz, O V Semenova, A V Salmin

引用次数: 0

Reactivity of the Arteries of the Cranial Pia Mater in Old Rats after Experimental Myocardial Infarction.

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-25 DOI: 10.1007/s10517-025-06347-5

V M Chertok, A E Kotsyuba, O P Kutafina

{"title":"Reactivity of the Arteries of the Cranial Pia Mater in Old Rats after Experimental Myocardial Infarction.","authors":"V M Chertok, A E Kotsyuba, O P Kutafina","doi":"10.1007/s10517-025-06347-5","DOIUrl":"10.1007/s10517-025-06347-5","url":null,"abstract":"In 24-month-old male Wistar rats, the endothelium-dependent (ED) and endothelium-independent (EI) responses of the arteries of the cranial pia mater (CPM) of branching orders I-V were studied by vital microscopy 30 days after the modeling of myocardial infarction. Sham-operated animals were used as a control. In both groups, a distinct response of the CPM vessels of different branching orders to vasodilators was observed: in pharmacological tests (acetylcholine, nitroglycerin), a dependence of the ED or EI vascular reactivity on the diameter of the arteries was found. In orders I-II branches, the myogenic ED response predominates, and the EI response of the vessels prevails in orders IV-V branches. In order III branches, both mechanisms were approximately equally developed. In most cases, the vascular reactivity and numerical density of arteries that changed their diameter were significantly lower in rats with myocardial infarction compared to control animals. Thus, in myocardial infarction, systemic disorders of the ED and EI reactivity of the CPM vessels of different diameters caused by endothelial dysfunction have been identified; the combination of these disorders with age-related changes determined rapid depletion of adaptive reserves and increased circulatory hypoxia in the brain. These processes lead to neurodegenerative changes, primarily in the oxygen-sensitive neurons of the frontal cortex, and to cognitive impairments.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"415-418"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Assessment of Manual Segmentation of Cerebral Infarction Lesions in Experimental Animals Based on Magnetic Resonance Imaging Using Artificial Intelligence. 利用人工智能对基于磁共振成像的实验动物脑梗塞病灶手动分割进行比较评估

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-28 DOI: 10.1007/s10517-025-06366-2

I L Gubskiy, D D Namestnikova, E A Cherkashova, I S Gumin, V V Kurilo, V P Chekhonin, K N Yarygin

引用次数: 0

Total Area of Interfibrillar Mitochondria in the Right Atrial Appendage Cardiomyocytes as an Index of the Functional State of the Cardiovascular System in Chronic Heart Failure.

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-26 DOI: 10.1007/s10517-025-06361-7

E A Kuzheleva, A A Garganeeva, O V Tukish, K N Vitt, S L Andreev, E E Syromyatnikova, E A Vladimirova

引用次数: 0

Activation of the Complement System and Changes in the Content of Modified Lipoproteins in Antiorthostatic Hypokinesia in Humans and Mice.

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-25 DOI: 10.1007/s10517-025-06346-6

I B Alchinova, B B Shoibonov, A A Puchkova, M Yu Karganov

引用次数: 0

Involvement of Receptor Apparatus in the Realization of Antinociceptive Activity of Songorine.

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-25 DOI: 10.1007/s10517-025-06349-3

Yu V Nesterova, A V Mukhomedzyanov, T N Povetyeva, N I Suslov, P V Kul'pin, O G Afanas'eva, A V Vychuzhanina, O Yu Rybalkina, G N Zyuz'kov, V V Zhdanov, M Yu Minakova

引用次数: 0

Application of Olfactory Ensheathing Cells in Collagen Hydrogels for Therapy of Experimental Spinal Cord Cysts.

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-28 DOI: 10.1007/s10517-025-06373-3

G A Fursa, A I Mukhina, A V Chadin, E K Karsuntseva, A D Voronova, V S Shishkina, P A Lazareva, A A Stepanenko, I V Reshetov, O V Stepanova, V P Chekhonin

引用次数: 0

Comparative Study of Mitochondrial DNA Abnormalities in Mesenchymal Stem Cells after Exposure to X-Ray Radiation in Low and Medium Doses.

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-29 DOI: 10.1007/s10517-025-06370-6

M V Dushenko, S A Abdullaev, M A Ignatov, A N Osipov

引用次数: 0

The Correlations of Attention with Microstructural Parameters of the Cerebral White Matter in Children and Adolescents.

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-27 DOI: 10.1007/s10517-025-06359-1

I N Chadova, O A Butova, G V Bicheva

{"title":"The Correlations of Attention with Microstructural Parameters of the Cerebral White Matter in Children and Adolescents.","authors":"I N Chadova, O A Butova, G V Bicheva","doi":"10.1007/s10517-025-06359-1","DOIUrl":"10.1007/s10517-025-06359-1","url":null,"abstract":"In the context of relevance and social significance of the problem of attention deficit disorder among schoolchildren, we performed 3D-visualization of the brain in children (n=17; age 9-12 years) and adolescents (n=16; age 13-15 years). We found correlations between fractional anisotropy of the white matter fiber tracts (reflecting the quantity of axons and myelinization) assessed by diffusion-weighted magnetic resonance imaging (dMRI) and attention indicators (accuracy and task completion time) in children and adolescents. The improvement of attention between the ages of 9 and 12 years (the second childhood period) was accompanied by an increase in fractional anisotropy in the corpus callosum, while the decrease of attention was associated with the increase in the level of anisotropy in the third segment of superior longitudinal fasciculus (SLFIII). The opposite results were obtained for adolescents. In both groups, the improvement in attention was associated with an increase in fractional anisotropy in the SLFI. A relationship of the obtained results with the data on different terms of maturation of the median (earlier development) and lateral (later development) cerebral structures in ontogeny is discussed.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"478-481"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephroblastoma Overexpressed Protein (NOV/CCN3) Elevated Expression of Inflammation Regulators in a Model of Sepsis-Induced Lung Injury.

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-29 DOI: 10.1007/s10517-025-06355-5

H Zhu, L Liu, M Yang, X Zhu, J Cai, H Huang

{"title":"Nephroblastoma Overexpressed Protein (NOV/CCN3) Elevated Expression of Inflammation Regulators in a Model of Sepsis-Induced Lung Injury.","authors":"H Zhu, L Liu, M Yang, X Zhu, J Cai, H Huang","doi":"10.1007/s10517-025-06355-5","DOIUrl":"10.1007/s10517-025-06355-5","url":null,"abstract":"Nephroblastoma overexpressed protein (NOV, also named CCN3), a member of the CCN (Cy61, CTGF, and NOV) family, is a critical biological marker of the severity of acute respiratory distress syndrome (ARDS). However, no evidence has been presented that CCN3 directly affects acute lung injury (ALI) or ARDS. Intratracheal infusion of LPS is an established method to simulate sepsis and induce ALI. To examine the effect of CCN3 on ALI, we developed in vivo and in vitro models of this disease on mice and type II alveolar epithelial A549 cells, respectively. To further clarify the role of CCN3 in ALI, we constructed a CCN3 overexpression model based on plasmid transfection. The results showed that CCN3 expression was up-regulated in LPS-induced ALI both in vivo and in vitro; this effect was time- and dose-dependent. ELISA revealed that overexpression of CCN3 increased the levels of proinflammatory cytokines IL-1β and TNFα. Flow cytometry and Western blotting showed that overexpression of CCN3 increased the expression of proapoptotic protein Bax and decreased the expression of anti-apoptotic protein Bcl-2, thereby promoting apoptosis of A549 cells. The results suggest that CCN3 antagonists can inhibit progression of inflammation and the development of apoptosis in lung epithelial cells, thereby exerting a possible therapeutic effect in ALI.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"453-459"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0