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Evaluation of Transferrin Level in Iron Supplementation after Partial Hepatectomy. 肝部分切除术后补铁对转铁蛋白水平的影响。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-26 DOI: 10.1007/s10517-025-06487-8
Weiwei Fang, Chang Pang, Xiying Li
{"title":"Evaluation of Transferrin Level in Iron Supplementation after Partial Hepatectomy.","authors":"Weiwei Fang, Chang Pang, Xiying Li","doi":"10.1007/s10517-025-06487-8","DOIUrl":"10.1007/s10517-025-06487-8","url":null,"abstract":"<p><p>Here we studied the effect of partial hepatectomy in patients with liver cancer (n = 48) on the level of serum iron and whether it can be corrected with iron supplementation therapy (IST; daily for 9 days). To identify whether the rapid decline in serum iron occurs only after hepatectomy, we studied this parameter in patients after pneumonectomy (n = 41). The hematocrit (HCT) and hemoglobin (HGB) levels were assayed by complete and differential blood counts, serum transferrin (TRF) and serum iron levels were measured by immunoturbidimetry and TPTZ (2,4,6-tri-(2-pyridyl)-5-triazine) method, respectively. After partial hepatectomy, the levels of serum iron and TRF in peripheral blood significantly decreased in comparison with the levels before surgery (p < 0.001). No significant elevation of serum iron and TRF was observed immediately after termination of IST, although these levels increased significantly 30 days after the onset of the therapy. Similar changes were observed in the control group in the same time points after the surgery, so IST exerted no positive effect. In contrast, both the incidence of intensive care unit admission and iron overload were higher in the IST group in comparison with the control. Serum iron sharply decreased after partial hepatectomy, which could be mainly due to the decrease in TRF. IST after hepatectomy did not improve HGB level. Thus, IST after partial hepatectomy was ineffective.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"348-354"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1,2,3,4-Dithiadiazole Derivative 3-(4-Nitrophenyl)-5-Phenyl-3H-1,2,3,4-Dithiadiazole-2-Oxide Affects Both STIM1- and STIM2-Dependent Store-Operated Calcium Channels. 1,2,3,4-二噻二唑衍生物3-（4-硝基苯基）-5-苯基- 3h -1,2,3,4-二噻二唑-2-氧化物影响STIM1-和STIM1-依赖性储存操作钙通道。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-24 DOI: 10.1007/s10517-025-06475-y
D A Grekhnev, Iu V Novikova, V N Yuskovets, N M Chernov, I P Yakovlev, A Yu Skopin, E V Kaznacheyeva, V A Vigont
{"title":"1,2,3,4-Dithiadiazole Derivative 3-(4-Nitrophenyl)-5-Phenyl-3H-1,2,3,4-Dithiadiazole-2-Oxide Affects Both STIM1- and STIM2-Dependent Store-Operated Calcium Channels.","authors":"D A Grekhnev, Iu V Novikova, V N Yuskovets, N M Chernov, I P Yakovlev, A Yu Skopin, E V Kaznacheyeva, V A Vigont","doi":"10.1007/s10517-025-06475-y","DOIUrl":"10.1007/s10517-025-06475-y","url":null,"abstract":"<p><p>Disturbances in calcium signaling and, in particular, store-operated calcium entry are associated with a wide range of diseases, including neurodegenerative, oncological, and autoimmune pathologies. Inhibitors of store-operated calcium entry have a neuroprotective effect and suppress metastasis, which makes store-operated channels an attractive target for drug design. Previously, we showed that 1,2,3,4-dithiadiazole derivatives are negative modulators of store-operated calcium channels that are normally activated by STIM1 and STIM2 proteins. Here, we studied the specificity of action of one of the most effective compounds of this class, 3-(4-nitrophenyl)-5-phenyl-3H-1,2,3,4-dithiadiazole-2-oxide, on STIM1- and STIM2-mediated store-operated calcium entry and concluded that it blocks calcium entry through store-operated channels activated by both STIM1 and STIM2.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"287-291"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Pathogenicity Island Markers among Commensal, Avian Pathogenic, and Uropathogenic Escherichia coli Strains. 共生、禽致病性和尿致病性大肠杆菌菌株致病性岛标记的流行。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06485-w
V S Mihailovskaya, P A Selivanova, M V Kuznetsova
{"title":"Prevalence of Pathogenicity Island Markers among Commensal, Avian Pathogenic, and Uropathogenic Escherichia coli Strains.","authors":"V S Mihailovskaya, P A Selivanova, M V Kuznetsova","doi":"10.1007/s10517-025-06485-w","DOIUrl":"10.1007/s10517-025-06485-w","url":null,"abstract":"<p><p>Virulence genes are often present on pathogenicity islands (PAIs) and serve as markers for specific pathogenic types of Escherichia coli. We studied the prevalence of PAIs associated with diarrheagenic (DEC PAI markers) and uropathogenic (UPEC PAI markers) E. coli among strains isolates from various sources, considering their phylogenetic group affiliation and pathogenic potential. DEC PAI markers were detected in 41.7% of fecal E. coli (FEC), 46.4% of avian pathogenic E. coli (APEC), and 84.6% of UPEC. UPEC more frequently contained PAIs carrying the siderophore biosynthesis gene clusters in comparison with FEC or APEC. UPEC PAI markers were equally prevalent in ExPEC groups (APEC and UPEC); however, PAIs exhibited greater diversity in uropathogenic strains. A positive correlation was found between the prevalence of the PAI genes and phylogenetic group B2, as well as the number of virulence genes present.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"336-341"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the Functional State of Liver Mitochondria in SHR Rats at Early Stages of Hypertension Development. 高血压早期SHR大鼠肝脏线粒体功能状态的研究。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-24 DOI: 10.1007/s10517-025-06476-x
E Yu Talanov, N V Khmil, N I Venediktova
{"title":"Assessment of the Functional State of Liver Mitochondria in SHR Rats at Early Stages of Hypertension Development.","authors":"E Yu Talanov, N V Khmil, N I Venediktova","doi":"10.1007/s10517-025-06476-x","DOIUrl":"10.1007/s10517-025-06476-x","url":null,"abstract":"<p><p>We studied functional state of liver mitochondria in 5-6-week-old SHR rats. Parameters of respiration and oxidative phosphorylation were assessed. The obtained data were compared with the results of the Western blotting of protein subunits forming the mitochondrial respiratory chain complexes in the liver. The activity of antioxidant enzymes (SOD, catalase, and glutathione peroxidase) and the rate of H<sub>2</sub>O<sub>2</sub> production were also examined in comparison with the control (WKY rats). An increase in the level of respiratory-chain complex V protein subunit, as well as a decrease in the activity of major mitochondrial antioxidant enzymes in SHR rat liver, was shown. The obtained results indicate the appearance of pathophysiological changes in the mitochondrial function in the liver (the organ that is not a primary target of the disease) of 5-6-week-old SHR rats (the age of first manifestations of arterial hypertension). These changes should be considered in future research into the pathogenesis of essential hypertension at its early stages.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"292-295"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Homeostatic" Cytokines Enhance the Expression of PD-1, Tim-3, and Their Ligands on Myeloid Cells. “稳态”细胞因子增强PD-1、Tim-3及其配体在髓细胞上的表达。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06484-x
O Yu Leplina, M A Tikhonova, E V Batorov, T V Tyrinova, E R Chernykh
{"title":"\"Homeostatic\" Cytokines Enhance the Expression of PD-1, Tim-3, and Their Ligands on Myeloid Cells.","authors":"O Yu Leplina, M A Tikhonova, E V Batorov, T V Tyrinova, E R Chernykh","doi":"10.1007/s10517-025-06484-x","DOIUrl":"10.1007/s10517-025-06484-x","url":null,"abstract":"<p><p>We studied the expression of checkpoint molecules in monocyte subsets and monocytic myeloid-derived suppressor cells (M-MS) and the effect of homeostatic cytokines (IL-2, IL-7, IL-15) on the expression of PD-1/PD-L1 and Tim-3/Galectin-9 by myeloid cells. Monocytes and M-MS were shown to express PD-1 and Tim-3, and the proportions of PD-1<sup>+</sup> monocytes and M-MS increased in multiple myeloma patients. Homeostatic cytokines enhanced the expression of inhibitory receptors (especially PD-1) by donor myeloid cells, the greatest effect was observed in M-MS. In addition, homeostatic cytokines increased PD-L1 expression in CD14<sup>+</sup>CD16<sup>-</sup> monocytes and M-MS, and Galectin-9 in M-MS. Increased expression of checkpoint molecules by myeloid cells under the stimulation of IL-2, IL-7, and IL-15 is discussed as a feedback mechanism of T-cell homeostatic proliferation induced by lymphopenia.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"331-335"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Lipid Metabolism under Alloxan Diabetes in Laboratory Animals and the Influence of Antidiabetic and Hypoglycemic Therapy on These Changes. 四氧嘧啶型糖尿病实验动物脂质代谢的变化及降糖降糖治疗对这些变化的影响
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-24 DOI: 10.1007/s10517-025-06495-8
I V Ralchenko, S Chilali, A D Shalabodov
{"title":"Changes in Lipid Metabolism under Alloxan Diabetes in Laboratory Animals and the Influence of Antidiabetic and Hypoglycemic Therapy on These Changes.","authors":"I V Ralchenko, S Chilali, A D Shalabodov","doi":"10.1007/s10517-025-06495-8","DOIUrl":"10.1007/s10517-025-06495-8","url":null,"abstract":"<p><p>Alloxan has been proposed as a diabetogenic agent due to its ability to destroy pancreatic β cells through the formation of free radicals, leading to oxidative stress, which has a significant role in the etiology and pathogenesis of diabetes and its complications. In Wistar rats with alloxan-induced diabetes, the levels of liver glycogen in the liver and the levels of total lipids and triglycerides in the liver, adipose tissue, and muscles were assessed over two months. Experimental diabetes was accompanied by a decrease in the levels of liver glycogen and an increase in the levels of triglycerides and total lipids in the liver, muscles, and adipose tissue. Treatment with insulin and metformin led to improvements in these parameters, with insulin having a more pronounced effect. The glycogen levels in the liver in rats receiving insulin was significantly higher than in animals treated with metformin (2767.86 and 1075.40 mg/100 g of tissue, respectively). The total lipid content in the liver significantly decreased against the background of insulin treatment compared to metformin (5730.90 and 8486.87 mg/100 g of tissue, respectively). Metformin administration led to an 11.9% reduction in liver triglycerides, while insulin reduced them by 25%. Oral administration of metformin for two months did not affect liver glycogen levels in alloxan-induced diabetic rats. Insulin injections increased liver glycogen levels and reduced total lipid and triglyceride levels in the liver. The hypolipidemic effect of these drugs appears to be due to the regulation of metabolism at the liver and adipose tissue levels.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"388-391"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiparkinsonian Activity of Benzenesulfonamide Derivatives, Selective MAO-B Inhibitors. 苯磺酰胺衍生物的抗帕金森活性，选择性MAO-B抑制剂。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06480-1
A L Khokhlov, V N Fedorov, A A Shetnev, M K Korsakov, S S Petukhov, V P Vdovichenko, A A Khokhlova, S Sh Suleimanov
{"title":"Antiparkinsonian Activity of Benzenesulfonamide Derivatives, Selective MAO-B Inhibitors.","authors":"A L Khokhlov, V N Fedorov, A A Shetnev, M K Korsakov, S S Petukhov, V P Vdovichenko, A A Khokhlova, S Sh Suleimanov","doi":"10.1007/s10517-025-06480-1","DOIUrl":"10.1007/s10517-025-06480-1","url":null,"abstract":"<p><p>The anti-parkinsonian activity of benzolsulfonamide selective MAO-B inhibitors was evaluated in a model of experimental parkinsonism in white mice (systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP). Six candidate compounds (laboratory codes S6-S8 and S11-S13) were analyzed. Rasagiline was used as the reference drug. Only compound S13 was comparable to rasagiline in preventing the development of rigidity and hypokinesia in animals and surpassed the reference drug in correcting emotional and behavioral activity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"312-316"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Class III Antiarrhythmic Drug Cavutilide Does Not Increase the Susceptibility of the Ventricles to Phenylephrine-Induced Tachyarrhythmias Due to the Direct Dependence of the Effect on the Frequency of Myocardial Activation. III类抗心律失常药物cavutilitde不增加心室对苯肾上腺素引起的心动过速的敏感性，因为其作用直接依赖于心肌激活频率。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06479-8
V S Kuzmin, A A Abramov, Yu V Egorov, D V Abramochkin
{"title":"Class III Antiarrhythmic Drug Cavutilide Does Not Increase the Susceptibility of the Ventricles to Phenylephrine-Induced Tachyarrhythmias Due to the Direct Dependence of the Effect on the Frequency of Myocardial Activation.","authors":"V S Kuzmin, A A Abramov, Yu V Egorov, D V Abramochkin","doi":"10.1007/s10517-025-06479-8","DOIUrl":"10.1007/s10517-025-06479-8","url":null,"abstract":"<p><p>Class III antiarrhythmic drugs used for the treatment of supraventricular tachyarrhythmias can induce polymorphic ventricular tachycardia known as \"torsade de pointes\" (TdP). This adverse side effect of antiarrhythmic drugs is more pronounced in impaired ventricular perfusion and limits the use of the drugs. In this work, the effects of the antiarrhythmic drug cavutilide were studied in a model of phenylephrine-induced potentiation of TdP. Cavutilide was administered acutely in combination with phenylephrine in non-anesthetized rabbits under continuous ECG monitoring. Cavutilide in the presence of phenylephrine induced pronounced ventricular extrasystoles almost without episodes of ventricular tachycardia or TdP paroxysms. The reference antiarrhythmic drug dofetilide under the same model conditions caused prolonged, multiple episodes of monomorphic ventricular tachycardia and frequent, repetitive paroxysms of high-frequency TdP. Thus, cavutilide demonstrates very low tendency to induce TdP under conditions of impaired myocardial perfusion, which can be explained by direct type of the dependence of its effect on the frequency of myocardium activation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"305-311"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of a HEK293 Cell Line with Stable Expression of Molecular Tools for Thermogenetic Activation. 产热激活分子工具稳定表达HEK293细胞系的建立
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-25 DOI: 10.1007/s10517-025-06492-x
V S Ovechkina, P S Suvorova, S K Andrianova, V V Belousov, A A Mozhaev
{"title":"Generation of a HEK293 Cell Line with Stable Expression of Molecular Tools for Thermogenetic Activation.","authors":"V S Ovechkina, P S Suvorova, S K Andrianova, V V Belousov, A A Mozhaev","doi":"10.1007/s10517-025-06492-x","DOIUrl":"10.1007/s10517-025-06492-x","url":null,"abstract":"<p><p>In modern biotechnological and biomedical research, it is often necessary to activate mammalian cells to obtain a specific response, such as changes in membrane potential or generation of action potential in excitable cells and tissues. Thermogenetics provides a rapid and controlled cellular response and is a promising tool for such tasks. In order to explore the potential of thermogenetic approaches, we generated the HEK293 cell line stably expressing the thermosensitive human TRPV1 ion channel. This cell line exhibited an increase in intracellular Ca<sup>2+</sup> ion concentration upon exposure to temperatures above 39°C and/or addition of capsaicin. The developed model can be used to further study the functional characteristics of exogenously expressed TRPV1 channels in mammalian cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"373-377"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in the Structure of Cytochrome C Active Center under the Action of Phosphatidic Acid and Temperature. 磷脂酸和温度作用下细胞色素C活性中心结构的变化。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-07-01 Epub Date: 2025-09-24 DOI: 10.1007/s10517-025-06478-9
I V Kirilina, G O Stepanov, Yu A Vladimirov, A N Osipov
{"title":"Changes in the Structure of Cytochrome C Active Center under the Action of Phosphatidic Acid and Temperature.","authors":"I V Kirilina, G O Stepanov, Yu A Vladimirov, A N Osipov","doi":"10.1007/s10517-025-06478-9","DOIUrl":"10.1007/s10517-025-06478-9","url":null,"abstract":"<p><p>The release of cytochrome C into the cytoplasm after formation of a complex with mitochondrial phospholipids underlays the mitochondrial pathway of apoptosis. Changes in the structure of cytochrome C complex active center depending on phosphatidic acid concentration and at different temperatures (25, 37, and 45°C) were studied. Changes in the active center structure were assessed by optical absorption at 695 nm and compared with the intensity of luminol-dependent chemiluminescence which is proportional to the peroxidase activity of cytochrome C-phosphatidic acid complex. It was found that increasing the temperature from 25 to 45°C leads to comparable changes in the conformation of cytochrome C active center and an increase in its peroxidase activity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"300-304"},"PeriodicalIF":0.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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