Bulletin of Experimental Biology and Medicine最新文献

Development of Cytocompatible Hydrogels as Potential Scaffolds for Surgical Applications. 细胞相容性水凝胶作为外科应用的潜在支架的发展。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-09 DOI: 10.1007/s10517-026-06757-z

A S Zakharov, I N Vasilovsky, N V Korotkova, N D Mzhavanadze, I A Suchkov, R E Kalinin, K A Borodina

{"title":"Development of Cytocompatible Hydrogels as Potential Scaffolds for Surgical Applications.","authors":"A S Zakharov, I N Vasilovsky, N V Korotkova, N D Mzhavanadze, I A Suchkov, R E Kalinin, K A Borodina","doi":"10.1007/s10517-026-06757-z","DOIUrl":"https://doi.org/10.1007/s10517-026-06757-z","url":null,"abstract":"Four hydrogel formulations were synthesized: a control (alginate/gelatin) and three modified variants containing polyethylene glycol (PEG as a plasticizer), boric acid (filler), and a combination of both. The swelling capacity, degradation rate, tensile strength, cytotoxicity toward a human dermal fibroblast culture, and resistance to surgical sutures were evaluated. To enhance mechanical strength, a combined physicochemical approach including chemical crosslinking and treatment with a concentrated ammonium sulfate solution was used to induce the Hofmeister effect. To assess the tensile strength and suturability, tubular structures were fabricated from the hydrogels using 3D-printed molds patented by the authors. The PEG hydrogels and combined composition (PEG + boric acid) showed the best cytocompatibility and fibroblast growth support. Treatment with ammonium sulfate increased the strength of the materials by 40-70 times, enabling surgical suturing and the formation of leak-proof anastomoses. It has been shown that the Hofmeister effect is reversible, indicating that biocompatibility is restored following implantation. Thus, a combined approach to fabrication of hydrogels is proposed that overcomes the critical dilemma of biomedical materials regarding \"strength vs biocompatibility\". In the future, the developed materials and technologies (including molds) will offer a promising pathway for creating personalized implants of complex shapes suitable for fixation using standard surgical techniques.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Donor Seminal Plasma on Sperm Functional Parameters in Male Infertility. 供体精浆对男性不育患者精子功能参数的影响。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-03 DOI: 10.1007/s10517-026-06764-0

A S Yakimova, E N Rimskaya, A V Gorevoy, N P Makarova, E A Kalinina

引用次数: 0

Contractile Apparatus of Cardiomyocytes in Premature Rats. 早产儿大鼠心肌细胞的收缩装置。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-01 DOI: 10.1007/s10517-026-06762-2

V V Ivanova, O N Serebryakova, A D Dolbnya, R I Pleshko, F V Alyabyev, I V Milto

引用次数: 0

Morphological and Molecular-Biological Characteristics of Wound Healing in Animals with High and Low Hypoxia Tolerance. 高、低缺氧耐受性动物伤口愈合的形态学和分子生物学特征。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-01 DOI: 10.1007/s10517-026-06763-1

D Sh Dzhalilova, I S Tsvetkov, M V Kirillova, E A Melnikova, V A Mkhitarov, M A Diatroptova, O V Makarova

{"title":"Morphological and Molecular-Biological Characteristics of Wound Healing in Animals with High and Low Hypoxia Tolerance.","authors":"D Sh Dzhalilova, I S Tsvetkov, M V Kirillova, E A Melnikova, V A Mkhitarov, M A Diatroptova, O V Makarova","doi":"10.1007/s10517-026-06763-1","DOIUrl":"https://doi.org/10.1007/s10517-026-06763-1","url":null,"abstract":"The morphological and molecular genetic characteristics of wound healing were investigated in male Wistar rats with high and low hypoxia tolerance (HT and HS rats, respectively). A full-thickness skin wound (diameter 16 mm) was inflicted in the interscapular region. On day 11 after wound infliction (proliferation phase), histological examination and morphometric analysis of the wound tissue were performed. The expression of the Hif1a, Epas1, Vegf, Nfkb, Il1b, Il6, Il10, Tnfa, and Tgfb genes in intact skin and in the wound granulation tissue was assessed by PCR, and the serum levels of HIF-1α, IL-1β, IL-6, and IL-10 were detected by ELISA. On day 11 of wound healing, reparative processes were more pronounced in HT animals, manifesting as a significantly smaller wound area compared to HS rats. The ratio of collagen fiber types on day 11 of wound healing in HT and HS rats did not differ significantly. Compared to HT rats, HS animals demonstrated higher expression of the Il6 and Tgfb genes in the granulation tissue, and higher serum levels of IL-6 protein. These data should be considered when conducting studies using animals with different hypoxia tolerance.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Properties and Biocompatibility of Titanium Alloy Implants with Calcium Phosphate Coating Containing 4-Chloro-2-((Pyridine-3-Ylimino)Methyl)Phenol. 含4-氯-2-（（吡啶-3-酰基）甲基）苯酚磷酸钙涂层钛合金植入物的抗菌性能及生物相容性

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-01 DOI: 10.1007/s10517-026-06759-x

N A Kononovich, I V Shipitsyna, A L Shastov, Yu A Enova, D S Popova, A V Dostovalova, A Yu Kurochkina, V V Savinova, D A Rychkova, N V Tushina, A N Nakoskin, A V Sharov

引用次数: 0

Efficacy of Topical Application of FENIX Gel in a Skin Excision Model in Sprague-Dawley Rats. FENIX凝胶局部应用于Sprague-Dawley大鼠皮肤切除模型的疗效。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-01 DOI: 10.1007/s10517-026-06760-4

A V Kholina, A Y Fedotova, V M Pavlov, M V Shinelev, N A Borozdina, S G Semushina, O I Patsap, E V Arshintseva, S Y Pushkin, P S Shmelin, A A Feoktistova, T V Masson, V V Salykin, I A Dyachenko

引用次数: 0

Effect of Exogenous Danio rerio kiss1 Peptide on Cortisol Levels in Early Embryos and Juvenile Forms of Teleost Fish. 外源肽对硬骨鱼早期胚胎和幼鱼皮质醇水平的影响。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-01 DOI: 10.1007/s10517-026-06752-4

M I Kostina, A A Nuzhnova, A A Blazhenko, S A Glebskaia, O N Bespalova

引用次数: 0

The Correlation Between Rhythmic Changes in Body Temperature and Large-Scale Fluctuations in Atmospheric Pressure in the 10-30-Minute Period Range. 10-30分钟范围内体温节律性变化与大范围大气压波动的相关性

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-01 DOI: 10.1007/s10517-026-06761-3

M E Diatroptov, S M Slesarev, M A Diatroptova

{"title":"The Correlation Between Rhythmic Changes in Body Temperature and Large-Scale Fluctuations in Atmospheric Pressure in the 10-30-Minute Period Range.","authors":"M E Diatroptov, S M Slesarev, M A Diatroptova","doi":"10.1007/s10517-026-06761-3","DOIUrl":"https://doi.org/10.1007/s10517-026-06761-3","url":null,"abstract":"The present study elucidated the relationship between daytime body temperature dynamics in male painted quail (Synoicus chinensis) with atmospheric pressure fluctuations. Atmospheric pressure was measured by three sensors positioned at the corners of an equilateral triangle with a side length of 18-20 km. The birds and the fourth pressure sensor were positioned in the center of this triangle. We demonstrated that body temperature dynamics correlated only with atmospheric pressure fluctuations recorded simultaneously by all sensors. This indicates that the ultradian body temperature rhythms in quails within the 10-30-min period range are linked not to the direct influence of atmospheric pressure, but rather to a factor generated during large-scale pressure fluctuations, or this biotropic factor itself is the cause of the observed atmospheric pressure fluctuations. It was also shown that the phase of these ultradian rhythms depends on local solar time, indicating that they are externally determined, possibly by the movement of the solar terminator.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemolytic Activity and Quantitative Characteristic of Pneumolysin Depending on the Culture Medium of Streptococcus pneumoniae Strains. 肺炎链球菌菌株培养基中溶血素的溶血活性及定量特征。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-01 DOI: 10.1007/s10517-026-06755-1

E A Kurbatova, N F Gavrilova, I V Yakovleva, A E Zaytsev, An A Poddubikov, E S Petukhova, I B Semenova, Yu V Volokh, N O Vartanova

引用次数: 0

Hemostatic Potential of the Blood in Mice with Transplanted Lewis Lung Carcinoma under the Action of Cisplatin. 顺铂作用下移植Lewis肺癌小鼠血液止血电位的研究。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-10-01 DOI: 10.1007/s10517-026-06751-5

E P Fedorova, M V Filonova, O Y Rybalkina, E P Zueva, L Y Kotlovskaya, A A Churin, V V Udut

引用次数: 0