{"title":"Prevalence of Pathogenicity Island Markers among Commensal, Avian Pathogenic, and Uropathogenic Escherichia coli Strains.","authors":"V S Mihailovskaya, P A Selivanova, M V Kuznetsova","doi":"10.1007/s10517-025-06485-w","DOIUrl":null,"url":null,"abstract":"<p><p>Virulence genes are often present on pathogenicity islands (PAIs) and serve as markers for specific pathogenic types of Escherichia coli. We studied the prevalence of PAIs associated with diarrheagenic (DEC PAI markers) and uropathogenic (UPEC PAI markers) E. coli among strains isolates from various sources, considering their phylogenetic group affiliation and pathogenic potential. DEC PAI markers were detected in 41.7% of fecal E. coli (FEC), 46.4% of avian pathogenic E. coli (APEC), and 84.6% of UPEC. UPEC more frequently contained PAIs carrying the siderophore biosynthesis gene clusters in comparison with FEC or APEC. UPEC PAI markers were equally prevalent in ExPEC groups (APEC and UPEC); however, PAIs exhibited greater diversity in uropathogenic strains. A positive correlation was found between the prevalence of the PAI genes and phylogenetic group B2, as well as the number of virulence genes present.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"336-341"},"PeriodicalIF":0.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06485-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Virulence genes are often present on pathogenicity islands (PAIs) and serve as markers for specific pathogenic types of Escherichia coli. We studied the prevalence of PAIs associated with diarrheagenic (DEC PAI markers) and uropathogenic (UPEC PAI markers) E. coli among strains isolates from various sources, considering their phylogenetic group affiliation and pathogenic potential. DEC PAI markers were detected in 41.7% of fecal E. coli (FEC), 46.4% of avian pathogenic E. coli (APEC), and 84.6% of UPEC. UPEC more frequently contained PAIs carrying the siderophore biosynthesis gene clusters in comparison with FEC or APEC. UPEC PAI markers were equally prevalent in ExPEC groups (APEC and UPEC); however, PAIs exhibited greater diversity in uropathogenic strains. A positive correlation was found between the prevalence of the PAI genes and phylogenetic group B2, as well as the number of virulence genes present.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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