O Yu Leplina, M A Tikhonova, E V Batorov, T V Tyrinova, E R Chernykh
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"Homeostatic" Cytokines Enhance the Expression of PD-1, Tim-3, and Their Ligands on Myeloid Cells.
We studied the expression of checkpoint molecules in monocyte subsets and monocytic myeloid-derived suppressor cells (M-MS) and the effect of homeostatic cytokines (IL-2, IL-7, IL-15) on the expression of PD-1/PD-L1 and Tim-3/Galectin-9 by myeloid cells. Monocytes and M-MS were shown to express PD-1 and Tim-3, and the proportions of PD-1+ monocytes and M-MS increased in multiple myeloma patients. Homeostatic cytokines enhanced the expression of inhibitory receptors (especially PD-1) by donor myeloid cells, the greatest effect was observed in M-MS. In addition, homeostatic cytokines increased PD-L1 expression in CD14+CD16- monocytes and M-MS, and Galectin-9 in M-MS. Increased expression of checkpoint molecules by myeloid cells under the stimulation of IL-2, IL-7, and IL-15 is discussed as a feedback mechanism of T-cell homeostatic proliferation induced by lymphopenia.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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