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Functional Assessment of Rat Sciatic Nerve Regeneration Using a Nerve Conduit Based on Ion Exchange Membrane. 利用基于离子交换膜的神经导管对大鼠坐骨神经再生进行功能评估
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06290-x
T V Rusinova, K I Melkonyan, R A Vinogradov, A S Asyakina, S A Knyshova
{"title":"Functional Assessment of Rat Sciatic Nerve Regeneration Using a Nerve Conduit Based on Ion Exchange Membrane.","authors":"T V Rusinova, K I Melkonyan, R A Vinogradov, A S Asyakina, S A Knyshova","doi":"10.1007/s10517-024-06290-x","DOIUrl":"10.1007/s10517-024-06290-x","url":null,"abstract":"<p><p>The problem with modern nerve conduits is inability to transmit nerve impulses to the distal part of the damaged nerve. Cationic conductivity is a necessary characteristic of the nerve conduit ensuring effective regeneration of the peripheral nerves. We performed a functional assessment of the regeneration of rat sciatic nerve using a nerve conduit based on an ion-exchange membrane. A sciatic nerve defect was experimentally simulated in Wistar rats with further implantation of the LF-4SK membrane. On days 60 and 90 after surgery, the sciatic functional index and the ratio of the shin girth of the operated limb to the intact limb were calculated; on day 90, an electrophysiological assessment of nerve recovery was carried out. The results of the study showed that the conduit based on the LF-4SK membrane optimizes the functional recovery of the sciatic nerve defect.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"101-104"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ischemia-Modified Albumin and Antioxidant Capacity of Blood Serum in Normal Pregnancy and Preeclampsia. 正常妊娠和子痫前期血清中的缺血修饰白蛋白和抗氧化能力
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06280-z
Yu O Teselkin, I V Babenkova, S Yu Lebedeva, Yu V Vykhristyuk, R I Shalina, V Yu Titov, M A Kurtser, Yu A Vladimirov, A N Osipov
{"title":"Ischemia-Modified Albumin and Antioxidant Capacity of Blood Serum in Normal Pregnancy and Preeclampsia.","authors":"Yu O Teselkin, I V Babenkova, S Yu Lebedeva, Yu V Vykhristyuk, R I Shalina, V Yu Titov, M A Kurtser, Yu A Vladimirov, A N Osipov","doi":"10.1007/s10517-024-06280-z","DOIUrl":"10.1007/s10517-024-06280-z","url":null,"abstract":"<p><p>A comparative study of oxidative stress markers (ischemia-modified albumin (IMA) and the blood serum antioxidant capacity) in normal pregnancy and preeclampsia was carried out. The IMA level and blood serum antioxidant capacity increased in the following order: healthy non-pregnant women→healthy pregnant women→patients with moderate preeclampsia→patients with severe preeclampsia (p<0.001). A significant positive correlation was revealed between blood serum antioxidant capacity and uric acid levels in all the examined groups. The results showed that oxidative stress in preeclampsia is more pronounced compared to normal pregnancy. The levels of IMA and the blood serum antioxidant capacity can be additional criteria for assessment of the severity of preeclampsia and predicting of its course.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"49-53"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kainate-Induced Reorganization the Dentate Gyrus of the Hippocampus Is Accompanied by Activation of Mitochondrial Fission in the Granular Layer Neurons. 凯因特诱导的海马齿状回重组伴随着颗粒层神经元线粒体裂变的激活
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06289-4
D N Voronkov, A V Egorova, E N Fedorova, M S Ryabova, A K Pavlova, A V Stavrovskaya, V S Sukhorukov
{"title":"Kainate-Induced Reorganization the Dentate Gyrus of the Hippocampus Is Accompanied by Activation of Mitochondrial Fission in the Granular Layer Neurons.","authors":"D N Voronkov, A V Egorova, E N Fedorova, M S Ryabova, A K Pavlova, A V Stavrovskaya, V S Sukhorukov","doi":"10.1007/s10517-024-06289-4","DOIUrl":"10.1007/s10517-024-06289-4","url":null,"abstract":"<p><p>The reorganization of the dentate gyrus of the hippocampus and changes in mitochondrial fission were evaluated using the kainate model of temporal lobe epilepsy. In 28 days after administration of 0.5 μg kainic acid, disturbances in the distribution of neuronal precursors in the subgranular zone of the hippocampus, thickening of the granular layer, and an increase in the content of synaptophysin in the molecular layer were detected. The observed changes were accompanied by an increase in the content of mitochondrial fission regulator protein Drp1 (dynamin related protein) and modification of the mitochondrial network in granular neurons of the dentate gyrus. These observations indicate a significant role of Drp1 in pathological rearrangements of the hippocampus during epileptogenesis and allow considering it as a potential target for pharmacological agents.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"96-100"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling of Isoproterenol-Induced Chronic Heart Failure in 24-Month-Old Rats. 异丙肾上腺素诱发 24 个月大鼠慢性心力衰竭的模型试验
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06277-8
T Yu Rebrova, V A Korepanov, I V Stepanov, S A Afanasiev
{"title":"Modeling of Isoproterenol-Induced Chronic Heart Failure in 24-Month-Old Rats.","authors":"T Yu Rebrova, V A Korepanov, I V Stepanov, S A Afanasiev","doi":"10.1007/s10517-024-06277-8","DOIUrl":"10.1007/s10517-024-06277-8","url":null,"abstract":"<p><p>The development of chronic heart failure (CHF) was induced in 24-month-old male Wistar rats weighing 550-600 g by 4 subcutaneous injections of isoproterenol hydrochloride (ISO) at a dose of 10 mg/kg with 3-day intervals. The control group received injections of saline. The rats were euthanized 60 days after the last ISO/saline injection. The mortality rate in the group of rats with CHF was 30%. Histological studies showed morphological changes in the myocardium, kidneys, and lungs typical of CHF. The presented scheme of ISO administration can be used for modeling CHF in 24-month-old rats.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"30-33"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Study of Effectiveness of Combined Proton-Neutron Irradiation of Tumor Cells In Vitro. 质子-中子联合辐照体外肿瘤细胞的有效性研究
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06285-8
S N Koryakin, M V Troshina, E V Koryakina, V I Potetnya, A A Pichkunova, V O Saburov, E I Kazakov, A A Lychagin, S A Ivanov, A D Kaprin, V I Zverev, A Yu Presnyakov
{"title":"The Study of Effectiveness of Combined Proton-Neutron Irradiation of Tumor Cells In Vitro.","authors":"S N Koryakin, M V Troshina, E V Koryakina, V I Potetnya, A A Pichkunova, V O Saburov, E I Kazakov, A A Lychagin, S A Ivanov, A D Kaprin, V I Zverev, A Yu Presnyakov","doi":"10.1007/s10517-024-06285-8","DOIUrl":"10.1007/s10517-024-06285-8","url":null,"abstract":"<p><p>Combined proton-neutron therapy can be the best opportunity for neutron radiation therapy due to highly conformal proton irradiation and high relative biological effectiveness of neutrons. The study compares 4 schemes of sequential in vitro exposure of Chinese hamster fibrosarcoma cells B14-150 to 14.5 MeV neutrons and a scanning beam of protons. Treatment efficiency increased with increasing the contribution of the neutron component to the total dose from 30 to 40% and the delivery of the neutron dose as the first fraction in the two-fraction proton-neutron exposure.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"75-78"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PDX1 as a Marker of Early Differentiation of Human Pancreatic Duct Cells. 作为人类胰腺导管细胞早期分化标志物的 PDX1
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-23 DOI: 10.1007/s10517-024-06292-9
A E Proshchina, Yu S Krivova, O S Godovalova, S V Saveliev
{"title":"PDX1 as a Marker of Early Differentiation of Human Pancreatic Duct Cells.","authors":"A E Proshchina, Yu S Krivova, O S Godovalova, S V Saveliev","doi":"10.1007/s10517-024-06292-9","DOIUrl":"10.1007/s10517-024-06292-9","url":null,"abstract":"<p><p>Epithelial progenitor cells of the primitive pancreatic ducts differentiate in 3 directions, which is accompanied by changes in cell phenotype. We analyze the distribution of the pancreatic and duodenal homeobox 1 (PDX1) in the epithelial cells of pancreatic ducts during the prenatal development in order to determine the potential use of this marker as an indicator of pancreatic cell maturation. Pancreatic autopsies from human fetuses (gestation weeks 17-23) were examined by immunohistochemical methods. In general, PDX1 was detected in the epithelial cells that are involved in various morphogenetic processes related to the growth and branching of the fetal pancreatic ducts. The intensive positive reaction to PDX1/cytokeratin 19 indicates immature (progenitor) polypotent ductal cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"110-114"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of In Vitro Low-Impulse Laser Irradiation on Morphofunctional Properties of Human Platelets. 体外低脉冲激光照射对人血小板形态功能特性的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-23 DOI: 10.1007/s10517-024-06297-4
M S Makarov, N V Borovkova, M V Storozheva, I N Ponomarev
{"title":"Effect of In Vitro Low-Impulse Laser Irradiation on Morphofunctional Properties of Human Platelets.","authors":"M S Makarov, N V Borovkova, M V Storozheva, I N Ponomarev","doi":"10.1007/s10517-024-06297-4","DOIUrl":"10.1007/s10517-024-06297-4","url":null,"abstract":"<p><p>We studied morphofunctional features of human platelets exposed in vitro to low-pulse laser radiation (LPLR) with different wavelengths. Platelet-rich plasma (PRP) was irradiated at wavelengths of 635, 488, and 355 nm. LPLR with λ=635 nm and 1 W power after 10 min caused degranulation of many platelets, formation of small platelet conglomerates, and accelerated platelet adhesion on glass. LPLR with λ=635 nm and 2 mW and LPLR with λ=488 nm did not cause significant changes in the morphofunctional platelet status. LPLR with λ=355 nm induced massive platelets' deformation, sharp decrease in their morphofunctional status without activation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"145-150"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptides in the Treatment of Gastric Ulcer. 多肽治疗胃溃疡。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI: 10.1007/s10517-024-06272-z
A S Kalnitsky, A Yu Zharikov
{"title":"Peptides in the Treatment of Gastric Ulcer.","authors":"A S Kalnitsky, A Yu Zharikov","doi":"10.1007/s10517-024-06272-z","DOIUrl":"10.1007/s10517-024-06272-z","url":null,"abstract":"<p><p>A promising area in the search for effective and safe methods of pharmacotherapy for gastric ulcers is the study of bioactive substances of natural origin and derivatives synthesized on the basis of these substances. The review presents modern information on various peptide-based substances that are pharmacologically active against gastric ulcer, including analogues of natural neuropeptides, synthetic substances with a specific amino acid sequence, as well as drugs derived from biological peptide complexes. Based on the results of the analysis, we have assessed the prospects of this pharmacological approach and outlined the areas for further research.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Biological Properties of the Bacteriodaceae Family Using the Caco-2 Cell Line. 利用 Caco-2 细胞系评估细菌科植物的生物特性
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06281-y
I V Podoprigora, M S Das, N B Zakharzhevskaya, L I Kafarskaya, B A Efimov
{"title":"Evaluation of the Biological Properties of the Bacteriodaceae Family Using the Caco-2 Cell Line.","authors":"I V Podoprigora, M S Das, N B Zakharzhevskaya, L I Kafarskaya, B A Efimov","doi":"10.1007/s10517-024-06281-y","DOIUrl":"10.1007/s10517-024-06281-y","url":null,"abstract":"<p><p>Disorders in the composition of the microbiota are often associated with pathological processes in the body. The use of new biotherapeutic drugs containing bacteria from normal microflora to correct these disorders may contribute to more effective treatment. The Bacteroidaceae family dominating in microflora is a candidate for inclusion in bacterial preparations. The adhesion properties of five bacterial strains from the Bacteroidaceae family were analyzed using the Caco-2 cell line and their effect on the transepithelial electrical resistance parameters (TEER) was assessed to determine the extent of their impact on the cell monolayer integrity. This approach allowed the selection of strain B. intestinalis 181, which was characterized by a moderate adhesion activity combined with a relatively low effect on the TEER parameter.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"54-57"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of Immunohistochemical Markers in the Walls of Pelvic Varicose Veins in Women. 女性盆腔静脉曲张静脉壁免疫组化标记物的表达。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-25 DOI: 10.1007/s10517-024-06298-3
M A Darenskaya, A A Semendyaev, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, A V Shcherbatykh, L I Kolesnikova
{"title":"Expression of Immunohistochemical Markers in the Walls of Pelvic Varicose Veins in Women.","authors":"M A Darenskaya, A A Semendyaev, D A Stupin, S I Kolesnikov, N V Semenova, D V Tukhieva, A V Shcherbatykh, L I Kolesnikova","doi":"10.1007/s10517-024-06298-3","DOIUrl":"10.1007/s10517-024-06298-3","url":null,"abstract":"<p><p>The tissue preparations of the pelvic veins obtained during laparoscopy were examined. The expression of markers of proliferation (Ki-67), apoptosis (p53), and angiogenesis (CD31, CD34), as well as estrogen and progesterone receptors in women with pelvic varicose veins was assessed by the immunohistochemical method. A decrease in the median expression of the proliferation marker (Ki-67) and estrogen and progesterone receptors and simultaneous increase in the expression of apoptosis marker (p53) and activation of angiogenesis processes (markers CD31 and CD34) were observed with increasing the severity of the disease. These data extend our understanding of the pathogenetic mechanisms of pelvic varicose veins and contribute to the development of methods of pathogenetically based targeted therapy.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"151-156"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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