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Protective Activity and Safety of Experimental Acellular Pertussis Vaccines Based on Antigenic Complexes Isolated from Biofilm and Planktonic Cultures of Bordetella pertussis. 基于从百日咳杆菌生物膜和浮游培养物中分离的抗原复合物的试验性百日咳疫苗的保护活性和安全性。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06187-9
E M Zaytsev, M V Britsina, M N Ozeretskovskaya, A E Zaitsev
{"title":"Protective Activity and Safety of Experimental Acellular Pertussis Vaccines Based on Antigenic Complexes Isolated from Biofilm and Planktonic Cultures of Bordetella pertussis.","authors":"E M Zaytsev, M V Britsina, M N Ozeretskovskaya, A E Zaitsev","doi":"10.1007/s10517-024-06187-9","DOIUrl":"10.1007/s10517-024-06187-9","url":null,"abstract":"<p><p>Continued circulation of the whooping cough pathogen, even in countries with high vaccine coverage, can be related to persistence of Bordetella pertussis biofilms in the respiratory tract. The films differ from planktonic cells by increased resistance to the host immune system and antibacterial drugs. The available acellular pertussis vaccines (aPV) containing antigens isolated from planktonic cultures of B. pertussis protect from severe forms of whooping cough, but do not effectively influence circulation of virulent strains in the subclinical forms of the disease and asymptomatic carriage. It is promising to create new generation aPV based on antigens isolated from biofilm cultures of B. pertussis capable of more effectively controlling the entire infectious cycle of whooping cough, including colonization, persistence, and transmission of the pathogen. From antigenic complexes isolated from the culture medium of biofilm and planktonic cultures of the strain B. pertussis No. 317 (serotype 1.2.3), experimental aPV were made: aPV-B and aPV-P, respectively. In intracerebral infection of mice with a virulent strain of B. pertussis, aPV-B demonstrated 2.5-fold higher protective activity than aPV-P and also more effectively reduced colonization of the lungs by B. pertussis cells in mice after intranasal infection with a virulent strain. Both vaccine preparations were safe and did not cause death in mice after administration of histamine.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats. 比较评估胰黄素及其肟在大鼠大脑中动脉闭塞中的神经保护活性
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06186-w
G A Chernysheva, V I Smolyakova, M B Plotnikov, O A Ulyakhina, A N Osipenko, A R Kovrizhina, A I Khlebnikov
{"title":"Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats.","authors":"G A Chernysheva, V I Smolyakova, M B Plotnikov, O A Ulyakhina, A N Osipenko, A R Kovrizhina, A I Khlebnikov","doi":"10.1007/s10517-024-06186-w","DOIUrl":"10.1007/s10517-024-06186-w","url":null,"abstract":"<p><p>The neuroprotective activity of tryptanthrin and its oxime was compared in male Wistar rats with a model of intraluminal occlusion of the middle cerebral artery. Neurobehavioral tests were performed 4, 24, and 48 h after focal cerebral infarction (FCI) using a modified neurological severity score (mNSS); additionally, the horizontal stability test, the plantar sensitivity test of the fore and hind limbs, holding on the tilted cage top test, and negative geotaxis test were performed. The size of FCI and the severity of brain tissue swelling were examined on day 2 after occlusion. Tryptanthrin and its oxime were administered at a dose of 10 mg/kg intraperitoneally during FCI, then daily for 2 days. In the control group, the mean score of neurological deficit remained at a high level for 2 days. FCI size was 43.8±3.4% of hemisphere area, and the hemisphere volume increased by 18.5±2.0% due to brain tissue swelling and edema. Administration of tryptanthrin and its oxime significantly decreased neurological deficits at all control points and reduced FCI size (by 24.2 and 30.4%, respectively) and brain tissue swelling of the affected hemisphere (by 64.9 and 62.7%, respectively). Therefore, the neuroprotective effect of tryptanthrine and its oxime in the acute period of FCI is largely determined by their anti-inflammatory activity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antigenotoxic Activity of Polyphenolic Composition BP-C2 in Mouse Germ Cells In Vivo. 多酚成分 BP-C2 对小鼠生殖细胞的体内抗原毒性活性
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-11 DOI: 10.1007/s10517-024-06182-0
A K Zhanataev, E A Anisina, A D Malikova, K L Pligina, S E Pigarev, E I Fedoros, A D Durnev, V N Anisimov
{"title":"Antigenotoxic Activity of Polyphenolic Composition BP-C2 in Mouse Germ Cells In Vivo.","authors":"A K Zhanataev, E A Anisina, A D Malikova, K L Pligina, S E Pigarev, E I Fedoros, A D Durnev, V N Anisimov","doi":"10.1007/s10517-024-06182-0","DOIUrl":"10.1007/s10517-024-06182-0","url":null,"abstract":"<p><p>In vivo antigenotoxic activity of BP-C2 composition (at doses of 60, 80, and 120 mg/kg) based on polyphenolic compounds derived from hydrolyzed lignin was evaluated in mouse germ cells. The BP-C2 composition dose-dependently reduced the aneugenic activity of topoisomerase II inhibitor etoposide in mouse oocytes without affecting the clastogenic activity of the genotoxicant. In mouse testicular cells, the BP-C2 composition reduced the DNA-damaging activity of the pro-oxidant genotoxicant dioxidine, but not etoposide. The cytoprotective activity of BP-C2 composition was revealed in relation to etoposide-induced cytotoxicity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Model of Accelerated Aging in CB6F2 Mice Induced by Ionizing Radiation. 电离辐射诱导的 CB6F2 小鼠加速衰老模型
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06190-0
E A Yakunchikova, M N Yurova, I S Drachyov, E A Radetskaya, K V Altukhov, A L Semenov, A V Panchenko, M L Tyndyk, V N Bykov, E I Fedoros
{"title":"Model of Accelerated Aging in CB6F2 Mice Induced by Ionizing Radiation.","authors":"E A Yakunchikova, M N Yurova, I S Drachyov, E A Radetskaya, K V Altukhov, A L Semenov, A V Panchenko, M L Tyndyk, V N Bykov, E I Fedoros","doi":"10.1007/s10517-024-06190-0","DOIUrl":"10.1007/s10517-024-06190-0","url":null,"abstract":"<p><p>A model for accelerated aging in mice was developed: CB6F2 mice aged 39-45 days were exposed to fractionated 4-fold relatively uniform γ-radiation (<sup>137</sup>Cs, 0.98 Gy/min) at a total dose of 6.8 Gy. Radiation exposure led to delayed active growth, leukopenia, and lymphopenia for over 1 year during the post-radiation period. The death of irradiated males and females occurred significantly earlier than in control group animals. Median lifespans in the experimental group were 35-38% lower than in the control group (p<0.001). Ionizing radiation exposure led to the early development of hair depigmentation, cachexia, and the development of aging-associated diseases. In irradiated mice, oncological pathology constituted 30-35% in the mortality structure, which is twice as often as in the control group. The developed model can be used to study the pathogenesis of accelerated aging under radiation exposure and the search for means of its prevention and treatment.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Evaluation of the Radioprotective Properties of Copper Chlorophyllin, Trolox, and Indralin in an Experiment on Mice. 在小鼠实验中比较评估叶绿素铜、三氯氧磷和吲哚啉的辐射防护特性
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06183-z
L A Romodin, O V Nikitenko, T M Bychkova, Yu A Zrilova, E D Rodionova, D A Bocharov
{"title":"Comparative Evaluation of the Radioprotective Properties of Copper Chlorophyllin, Trolox, and Indralin in an Experiment on Mice.","authors":"L A Romodin, O V Nikitenko, T M Bychkova, Yu A Zrilova, E D Rodionova, D A Bocharov","doi":"10.1007/s10517-024-06183-z","DOIUrl":"10.1007/s10517-024-06183-z","url":null,"abstract":"<p><p>The radioprotective properties of copper chlorophyllin (100 and 150 μg/g), the standard antioxidant trolox (100 and 200 μg/g), and the standard radioprotector indralin (100 and 150 μg/g) were compared in male ICR mice (CD-1) subjected to whole-body irradiation (X-ray radiation) in doses of 6, 6.5, and 6.75 Gy. Animal survival was analyzed using the Kaplan-Meier method, and the significance of differences was evaluated using the log-rank test method. Dose change factors determined using the Phinney probit analysis were 1.1, 1.0, and 1.8 for chlorophyllin, trolox, and indralin at a dose of 100 μg/g body weight, respectively. The insignificant radioprotective properties of chlorophyllin and their absence in trolox when administered prophylactically do not rule out their possible radioprotective properties like a radiomodulator that protects the body after irradiation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastroprotective Effect of GABA in Metabolic Stress. GABA 在代谢应激中的胃保护作用
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06178-w
N S Tropskaya, Yu V Gurman, T S Popova, A A Kanibolotsky
{"title":"Gastroprotective Effect of GABA in Metabolic Stress.","authors":"N S Tropskaya, Yu V Gurman, T S Popova, A A Kanibolotsky","doi":"10.1007/s10517-024-06178-w","DOIUrl":"10.1007/s10517-024-06178-w","url":null,"abstract":"<p><p>We studied the effect of enteral administration of GABA on the gastric mucosa in male Wistar rats (n=47) with modeled metabolic stress (food deprivation for 9 days with free access to water). The relative weights of the adrenal glands and thymus were determined, and histological examination of the stomach was performed. In control rats, modeling the metabolic stress was accompanied by the development of erosive damage to the gastric mucosa related to blood supply disturbances. Administration of GABA prevented erosions and exhibited a pronounced gastroprotective effect. Thus, administration of GABA can be a promising method for the prevention and treatment of erosive gastric lesions associated with metabolic stress.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucocorticoid Deflazacort Normalizes the Ultrastructure of Skeletal Muscles and the State of the Colon Microbiota in Dystrophin-Deficient Mice. 糖皮质激素地氟沙考可使Dystrophin缺陷小鼠骨骼肌的超微结构和结肠微生物群状态正常化
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06184-y
M V Dubinin, I B Mikheeva, A E Stepanova, E K Pavlova, T P Gazheeva, K N Belosludtsev
{"title":"Glucocorticoid Deflazacort Normalizes the Ultrastructure of Skeletal Muscles and the State of the Colon Microbiota in Dystrophin-Deficient Mice.","authors":"M V Dubinin, I B Mikheeva, A E Stepanova, E K Pavlova, T P Gazheeva, K N Belosludtsev","doi":"10.1007/s10517-024-06184-y","DOIUrl":"10.1007/s10517-024-06184-y","url":null,"abstract":"<p><p>We studied the effect of enteral administration of the glucocorticoid deflazacort (DFC, 1.2 mg/kg per day, 28 days) on the state of skeletal muscles and tissue ultrastructure, as well as the composition of the colon microbiota in dystrophin-deficient mdx mice. DFC has been shown to reduce the intensity of degeneration/regeneration cycles in muscle fibers of mdx mice. This effect of DFC was accompanied by normalization of the size of sarcomeres of skeletal muscles of mdx mice, improvement of the ultrastructure of the subsarcolemmal population of mitochondria, and an increase in the number of organelles, as well as normalization of the number of contact interactions between the sarcoplasmic reticulum and mitochondria. In addition, DFC had a corrective effect on the colon microbiota of mdx mice, which manifested in an increase in the number of the Bifidobacterium genus microorganisms and a decrease in the level of E. coli with reduced enzymatic activity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Morphological Study of Larynx APUD-Cells in Asphyxial Type of Drowning in Fresh Water (Experimental Study). 淡水窒息型溺水者喉部 APUD 细胞的定量形态学研究（实验研究）。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-06-01 Epub Date: 2024-08-01 DOI: 10.1007/s10517-024-06173-1
R U Giniatullin
{"title":"Quantitative Morphological Study of Larynx APUD-Cells in Asphyxial Type of Drowning in Fresh Water (Experimental Study).","authors":"R U Giniatullin","doi":"10.1007/s10517-024-06173-1","DOIUrl":"10.1007/s10517-024-06173-1","url":null,"abstract":"<p><p>An additional microscopic diagnostic sign has been identified for verification of asphyxial type of drowning. In white non-linear male rats (age 2 months) subjected to free drowning, significant hyperplasia of argyrophilic and morphofunctional activity of serotonin-containing APUD-cells of the laryngeal mucosa were revealed under conditions of acute anoxia in comparison with the intact control. These changes promote the development of laryngospasm, which prevents water penetration into the airways and lungs in asphyxial type of drowning. The presence of statistically significant hyperplasia of argyrophilic and morphofunctional activity of serotonin-containing APUD-cells of the laryngeal mucosa under conditions of acute anoxia can be used as an additional diagnostic criterion for asphyxial type of drowning in experimental studies.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of the Pharmabiotic U-21 under Conditions of a Combined Neuroinflammatory Model of Parkinson's Disease in Rats. 药用生物制剂 U-21 在帕金森病联合神经炎症模型条件下对大鼠的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-06-01 Epub Date: 2024-08-02 DOI: 10.1007/s10517-024-06161-5
A V Stavrovskaya, D N Voronkov, M V Marsova, A S Olshansky, A S Gushchina, V N Danilenko, S N Illarioshkin
{"title":"Effects of the Pharmabiotic U-21 under Conditions of a Combined Neuroinflammatory Model of Parkinson's Disease in Rats.","authors":"A V Stavrovskaya, D N Voronkov, M V Marsova, A S Olshansky, A S Gushchina, V N Danilenko, S N Illarioshkin","doi":"10.1007/s10517-024-06161-5","DOIUrl":"10.1007/s10517-024-06161-5","url":null,"abstract":"<p><p>Data on the participation of microbiota in the development of Parkinson's disease allow us to discuss the ability of bacterial preparations to influence the processes leading to neurodegeneration. We studied the effect of oral administration of Limosilactobacillus fermentum U-21 lyophilisate on a model of Parkinson's disease in rats induced by combined intranigral injection of LPS and systemic administration of paraquat. The toxins significantly increased the number of missteps in the \"narrowing beam walking\" test, but a tendency to a decrease in this parameter was shown after treatment with U-21. It should be noted that U-21 did not reduce the neuronal death in the substantia nigra, but mitigated the inflammatory glial response, decreased the accumulation of phosphorylated α-synuclein and complement protein C3. Our study demonstrated the efficiency of the combined model of parkinsonism and reduction of proinflammatory changes under the influence of pharmabiotic without changes in the nigral neuronal death and motor deficits.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Adjuvant Compositions Based on Squalene Ensures Induction of Neutralizing Antibodies against SARS-CoV-2. 使用基于角鲨烯的佐剂复合物可确保诱导针对 SARS-CoV-2 的中和抗体。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-06-01 Epub Date: 2024-08-02 DOI: 10.1007/s10517-024-06160-6
E A Volosnikova, N V Volkova, V V Ermolaev, M B Borgoyakova, V S Nesmeyanova, A V Zaykovskaya, O V Pyankov, B N Zaitsev, S V Belenkaya, A A Isaeva, D N Shcherbakov
{"title":"Use of Adjuvant Compositions Based on Squalene Ensures Induction of Neutralizing Antibodies against SARS-CoV-2.","authors":"E A Volosnikova, N V Volkova, V V Ermolaev, M B Borgoyakova, V S Nesmeyanova, A V Zaykovskaya, O V Pyankov, B N Zaitsev, S V Belenkaya, A A Isaeva, D N Shcherbakov","doi":"10.1007/s10517-024-06160-6","DOIUrl":"10.1007/s10517-024-06160-6","url":null,"abstract":"<p><p>Squalene-based adjuvant compositions that can provide effective induction of specific humoral immune response have been developed. Recombinant receptor-binding domain (RBD) of surface S-protein of SARS-CoV-2 was used to evaluate the properties of the composition. Immunization of mice with the developed squalene-based compositions in combination with RBD allows obtaining high titers of specific antibodies: from 10<sup>5</sup> to 2×10<sup>6</sup>. The blood sera from immunized mice exhibit neutralizing activity against SARS-CoV-2 Delta variant (B.1.617.2) with a titer up to 1:2000.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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