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Correction to the article "RSF-1/hSNF2H Promotes the Proliferation and Migration of Adenoid Cystic Cancer Cells". 对文章“RSF-1/hSNF2H促进腺样囊性癌细胞的增殖和迁移”的更正。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 DOI: 10.1007/s10517-026-06673-2
Xiaorong Wang, Aichao Gao, Xingdong Liu, Zhe Yang
{"title":"Correction to the article \"RSF-1/hSNF2H Promotes the Proliferation and Migration of Adenoid Cystic Cancer Cells\".","authors":"Xiaorong Wang, Aichao Gao, Xingdong Liu, Zhe Yang","doi":"10.1007/s10517-026-06673-2","DOIUrl":"10.1007/s10517-026-06673-2","url":null,"abstract":"","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"660"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colon Adenocarcinoma Cell-Derived Galectins-1,3 Modulate Differentiation of CD4+ T Lymphocytes In Vitro. 结肠癌细胞源性半凝集素-1,3在体外调节CD4+ T淋巴细胞的分化。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06692-z
V S Poletika, G V Reingardt, A V Kurnosenko, Yu V Kolobovnikova, O I Urazova
{"title":"Colon Adenocarcinoma Cell-Derived Galectins-1,3 Modulate Differentiation of CD4<sup>+</sup> T Lymphocytes In Vitro.","authors":"V S Poletika, G V Reingardt, A V Kurnosenko, Yu V Kolobovnikova, O I Urazova","doi":"10.1007/s10517-026-06692-z","DOIUrl":"10.1007/s10517-026-06692-z","url":null,"abstract":"<p><p>We investigated how selective inhibition of galectin-1 and galectin-3 expressed by COLO 201 colorectal adenocarcinoma cells modulates CD4+ T lymphocyte differentiation in vitro. The mRNA expression levels of the transcription factors T-bet (TBX21), RORC2, and Foxp3 were analyzed in peripheral blood mononuclear cells (PBMCs) from colorectal cancer patients and healthy donors following co-culture with COLO 201 cells in the presence of galectin-1 inhibitor OTX 008, galectin-3 inhibitor GB1107, or both. Inhibition of galectin-1 in co-cultures increased TBX21 and RORC2 mRNA expression while suppressing FOXP3 in PBMCs from both groups. In patient-derived PBMCs, galectin-3 inhibition produced a similar effect. Conversely, in healthy donor cells, galectin-3 blockade suppressed RORC2 and induced FOXP3 expression. Notably, the most pronounced downregulation of FOXP3 was achieved by simultaneously inhibiting both galectins.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"638-641"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Multipotent Mesenchymal Stromal Cells Exhibit Resistance to Long-Term Simulated Microgravity. 人类多能间充质间质细胞表现出对长期模拟微重力的抵抗。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-02-01 Epub Date: 2026-04-24 DOI: 10.1007/s10517-026-06666-1
E A Tyrina, I V Andrianova, E R Andreeva, Yu A Romanov, L B Buravkova
{"title":"Human Multipotent Mesenchymal Stromal Cells Exhibit Resistance to Long-Term Simulated Microgravity.","authors":"E A Tyrina, I V Andrianova, E R Andreeva, Yu A Romanov, L B Buravkova","doi":"10.1007/s10517-026-06666-1","DOIUrl":"10.1007/s10517-026-06666-1","url":null,"abstract":"<p><p>We performed a comprehensive analysis of changes in the functional state of human multipotent mesenchymal stromal cells derived from the umbilical cord tissue (UC-MSCs) after a 30-day simulated microgravity exposure. It was found that simulated microgravity induced changes in the expression of stromal markers and cell cycle regulators in UC-MSCs but did not alter their viability and expression of the cytoskeletal genes. We also observed shifts in the expression of adhesion molecules and enhanced secretion of proinflammatory cytokines. These findings indicate that microgravity modulates functional properties of MSCs and confirm the possibility of using these cells as a model system for studies of the molecular and cellular mechanisms underlying adaptation to microgravity during long-term spaceflights.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"509-514"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Polymorphism of HLA Class II Genes in Postvaccination Plague Immunity. HLAⅱ类基因多态性在鼠疫疫苗接种后免疫中的作用
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-02-01 Epub Date: 2026-04-27 DOI: 10.1007/s10517-026-06656-3
K M Korytov, V I Dubrovina, A B Pyatyidesyatnikova, D D Bryukhova, N O Kiseleva, E A Kuzina, S V Balakhonov
{"title":"The Role of Polymorphism of HLA Class II Genes in Postvaccination Plague Immunity.","authors":"K M Korytov, V I Dubrovina, A B Pyatyidesyatnikova, D D Bryukhova, N O Kiseleva, E A Kuzina, S V Balakhonov","doi":"10.1007/s10517-026-06656-3","DOIUrl":"10.1007/s10517-026-06656-3","url":null,"abstract":"<p><p>We evaluated the association of alleles of human leukocyte antigen (HLA) class II genes and the levels of secretion of IL-4 and IFNγ in the blood of individuals vaccinated/revaccinated with a live plague vaccine and living in the Gorno-Altai high-mountain and Tuvinian mountain natural plague foci. Significant differences were identified in the blood content of IL-4 and IFNγ in volunteers with different variants of alleles in the HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci, which indicates a substantial influence of their polymorphism on the immunological reactivity during specific plague prevention. Further research within the framework of immunological monitoring of the population living in plague-endemic territories will allow identifying the features of the influence of polymorphism of HLA class II genes on the formation of post-vaccination anti-plague immunity in humans.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"450-455"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor Cell Lines as a Biosensor Substrate for Pathological Aging and CNS Tumors. 肿瘤细胞系作为病理衰老和中枢神经系统肿瘤的生物传感器底物。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-02-01 Epub Date: 2026-04-28 DOI: 10.1007/s10517-026-06657-2
V V Kudelkina, A M Kosyreva, E A Miroshnichenko
{"title":"Tumor Cell Lines as a Biosensor Substrate for Pathological Aging and CNS Tumors.","authors":"V V Kudelkina, A M Kosyreva, E A Miroshnichenko","doi":"10.1007/s10517-026-06657-2","DOIUrl":"10.1007/s10517-026-06657-2","url":null,"abstract":"<p><p>Primary screening of the sera from aging Wistar rats and animals with high-grade gliomas was performed using the following cell lines: Gasser's node neuroma (NGUK, trigeminal schwannoma) and high-grade glioma 11-9-2. Targeted analysis of the transcripts of the marker genes S100b (involved in nervous system homeostasis and damage), Sox2 (stemness marker), and Mki67 (proliferation marker), along with mitotic cell counting revealed statistically significant differences in transcriptional activity between the groups. This initial assessment of the sensitivity of cell lines to sera from animals with CNS pathology indicates its potential for further detailed development as a biosensor test system.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"456-462"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variability of the Immunosuppressive Properties of Glioma Cell Lines. 胶质瘤细胞系免疫抑制特性的变异性。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-02-01 Epub Date: 2026-04-24 DOI: 10.1007/s10517-026-06665-2
I V Kholodenko, R Yu Saryglar, A Y Lupatov, K V Kovalskaya, O A Bystrykh, A V Kuprin, K N Yarygin
{"title":"Variability of the Immunosuppressive Properties of Glioma Cell Lines.","authors":"I V Kholodenko, R Yu Saryglar, A Y Lupatov, K V Kovalskaya, O A Bystrykh, A V Kuprin, K N Yarygin","doi":"10.1007/s10517-026-06665-2","DOIUrl":"10.1007/s10517-026-06665-2","url":null,"abstract":"<p><p>Immunotherapeutic methods, such as the use of checkpoint inhibitors, CAR T cells, dendritic cell vaccines, etc., offer promising approach to the treatment of glioblastomas. Dendritic cell (DC)-based vaccines used in glioma therapy have been well studied and are effective in some cases. However, the use of DC vaccines for the treatment of patients with gliomas, though shows promising results, is still limited by the suboptimal choice of tumor antigen and the method of its loading, as well as the immunosuppressive nature of the tumor cell microenvironment. In this work, we showed that glioma cell lines express a broad spectrum of immune checkpoints, suppress the maturation of allogeneic DCs during direct co-culturing, and do not stimulate the proliferation of allogeneic lymphocytes. Lymphocytes primed with dendritic cells loaded with the corresponding tumor lysates effectively lysed only two of three glioma cell lines, T98G and U373 MG, whereas 1321N1 cells completely suppressed the cytotoxic activity of lymphocytes primed by co-culturing with DCs loaded with the lysate of these cells. Thus, the efficacy of DC vaccines may be related to the individual characteristics of glioma cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"499-508"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CK19 and PDX1 as Markers of Differentiation and Maturation of Pancreatic Islet Endocrine Cells. CK19和PDX1作为胰岛内分泌细胞分化和成熟的标志物。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-02-01 Epub Date: 2026-04-24 DOI: 10.1007/s10517-026-06663-4
A E Proshchina, Yu S Krivova, A S Kharlamova, G A Sonin, S V Saveliev
{"title":"CK19 and PDX1 as Markers of Differentiation and Maturation of Pancreatic Islet Endocrine Cells.","authors":"A E Proshchina, Yu S Krivova, A S Kharlamova, G A Sonin, S V Saveliev","doi":"10.1007/s10517-026-06663-4","DOIUrl":"10.1007/s10517-026-06663-4","url":null,"abstract":"<p><p>We studied patterns of staining for early cell markers in the forming pancreatic islets during months 5 and 6 of human prenatal development. The study was performed on 10 autopsy specimens of the fetal pancreas (gestational age 16-23 weeks) using multiple immunohistochemical staining with antibodies to PDX1 and CK19. Two main types of cells have been identified: cells with the intense staining for PDX1 and weak or no staining for CK19 that were located in the central area of the mantle islets or at one the poles of bipolar islets and may be referred to a population of β cells and cells with staining for CK19 and weak or no staining for PDX1 that were located at the periphery of the mantle islets or at the other pole of bipolar islets and may be referred to a population of α cells. The islet cells had additional phenotypes based on the staining for CK19 and PDX1, which requires further studies to determine the fate of these cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"487-491"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphometry of Mast Cells in the Tongue Tissues of the White Rats under Stress Conditions. 应激条件下大鼠舌部肥大细胞形态测定。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-02-01 Epub Date: 2026-04-29 DOI: 10.1007/s10517-026-06669-y
M Yu Fleishman, A A Salnikov, Yu B Malofey, O Yu Volodina, N Yu Ilyina
{"title":"Morphometry of Mast Cells in the Tongue Tissues of the White Rats under Stress Conditions.","authors":"M Yu Fleishman, A A Salnikov, Yu B Malofey, O Yu Volodina, N Yu Ilyina","doi":"10.1007/s10517-026-06669-y","DOIUrl":"10.1007/s10517-026-06669-y","url":null,"abstract":"<p><p>We studied the effect of repeated immobilization stress against the background of preliminary intranasal administration of valine-containing glyproline Pro-Gly-Pro-Val (100 μg/kg) on the morphometric parameters of mast cells (mastocytes) in the connective tissue of the mucosal and muscular layers of the tongue in male Wistar rats. Repeated stress increased in the density of distribution, mean size, and degranulation index of mast cells in both layers. Preliminary administration of the peptide decreased the mean area and degranulation index of mast cells, which suggests that the peptide has a stabilizing effect on the morphological structure and activity of mast cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"530-534"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential of Antioxidant and Cardioprotective Activity of a New Pyridoxine and Fumaric Acid Derivative as an Inductor of Transcription Factor Nrf2. 一种新的吡哆醇和富马酸衍生物作为转录因子Nrf2诱导剂的抗氧化和心脏保护活性潜力。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-02-01 Epub Date: 2026-04-27 DOI: 10.1007/s10517-026-06667-0
A A Balakina, A D Podgurskaya, V A Mumyatova, T S Stupina, T R Prikhodchenko, O S Suvorova, S V Blokhina, S Ya Gadomsky, D V Mishchenko
{"title":"Potential of Antioxidant and Cardioprotective Activity of a New Pyridoxine and Fumaric Acid Derivative as an Inductor of Transcription Factor Nrf2.","authors":"A A Balakina, A D Podgurskaya, V A Mumyatova, T S Stupina, T R Prikhodchenko, O S Suvorova, S V Blokhina, S Ya Gadomsky, D V Mishchenko","doi":"10.1007/s10517-026-06667-0","DOIUrl":"10.1007/s10517-026-06667-0","url":null,"abstract":"<p><p>The aim of the study was to evaluate the biological activity of a new type of cardioprotectors, activators of Nrf2, based on pyridoxine and fumaric acid derivatives in vitro and in vivo. It was found that di(3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridinium) fumarate is an effective activator of Nrf2 transcription factor and exhibits cytoprotective and antioxidant activity in vitro on a cardiomyocyte model. In addition, this compound reduces the cardiotoxic effect of doxorubicin in vivo by suppressing the development of oxidative processes and activating the Nrf2-dependent antioxidant response in the heart. The studied pyridoxine and fumaric acid derivative has high potential as a candidate medication for reducing the side effects of anthracycline antibiotics, as well as for protecting heart cells in various cardiovascular diseases and age-related changes. The revealed effects are of great importance for the development of approaches to designing a new type of cardioprotective compounds, activators of the transcription factor Nrf2.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"515-523"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible Ways of Reducing Adverse Events Associated with mRNA Vaccines Encapsulated in Lipid Nanoparticles. 减少脂质纳米颗粒包裹mRNA疫苗相关不良事件的可能方法
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-02-01 Epub Date: 2026-04-24 DOI: 10.1007/s10517-026-06645-6
L A Kisakova, S A Ilyicheva, A P Rudometov
{"title":"Possible Ways of Reducing Adverse Events Associated with mRNA Vaccines Encapsulated in Lipid Nanoparticles.","authors":"L A Kisakova, S A Ilyicheva, A P Rudometov","doi":"10.1007/s10517-026-06645-6","DOIUrl":"10.1007/s10517-026-06645-6","url":null,"abstract":"<p><p>mRNA vaccines have a number of advantages over traditional vaccines: high safety (no risk of infection, minimal possibility of integration into the genome), the ability to induce both cellular and humoral immune responses, as well as the possibility of repeated administration due to the absence of antiviral immunity. The effectiveness of Moderna and Pfizer/BioNTech products that use lipid nanoparticles for mRNA delivery have been proven, but they have disadvantages, including the need for ultra-low-temperature storage and side effects associated with lipid components of vaccines. Polymers, polypeptides, dendrimers, and other delivery systems are being investigated as alternative methods of mRNA delivery. This review analyzes the side effects of mRNA vaccines encapsulated in lipid nanoparticles and promising approaches to reducing their reactogenicity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"395-401"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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