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Studying the Influence of Ischemic Liver Damage on the Pharmacokinetics of a Phenolic Antioxidant. 缺血性肝损伤对酚类抗氧化剂药代动力学影响的研究。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-15 DOI: 10.1007/s10517-025-06330-0
E A Yanovskaya, G A Frelikh, A P Lakeev, G A Chernysheva, V I Smolyakova
{"title":"Studying the Influence of Ischemic Liver Damage on the Pharmacokinetics of a Phenolic Antioxidant.","authors":"E A Yanovskaya, G A Frelikh, A P Lakeev, G A Chernysheva, V I Smolyakova","doi":"10.1007/s10517-025-06330-0","DOIUrl":"10.1007/s10517-025-06330-0","url":null,"abstract":"<p><p>A new approach has been developed to study the pharmacokinetics of 2,6-diisobornyl-4-methylphenol, a phenolic antioxidant, after intragastric administration at a dose of 10 mg/kg to male Wistar rats with ischemia/reperfusion liver injury. The control group consisted of rats without pathology. A catheter previously implanted into the jugular vein of the animals, allowed repeated blood sampling and monitoring of the pharmacokinetic profile of the substance in each animal. Pharmacokinetic studies usually involve healthy animals, but the ischemia/reperfusion injury of the liver disrupted its functions, potentially altering drug metabolism and pharmacokinetics. Analysis of actual blood plasma samples confirmed the effectiveness of the proposed approach: changes in the pharmacokinetics of the phenolic antioxidant were revealed during liver ischemia/reperfusion injury in rats.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"323-326"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subpopulation Alterations of Vascular Endothelial Cells in the Cerebral Cortex in Experimental Models of Alzheimer's Disease. 阿尔茨海默病实验模型中大脑皮层血管内皮细胞亚群的改变
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-14 DOI: 10.1007/s10517-025-06339-5
T I Baranich, A S Averchuk, M V Kukla, N A Rozanova, A V Stavrovskaya, V V Glinkina, V S Sukhorukov, A B Salmina
{"title":"Subpopulation Alterations of Vascular Endothelial Cells in the Cerebral Cortex in Experimental Models of Alzheimer's Disease.","authors":"T I Baranich, A S Averchuk, M V Kukla, N A Rozanova, A V Stavrovskaya, V V Glinkina, V S Sukhorukov, A B Salmina","doi":"10.1007/s10517-025-06339-5","DOIUrl":"10.1007/s10517-025-06339-5","url":null,"abstract":"<p><p>Angiogenesis is regulated by various types of endothelial cells: tip cells, stalk cells, and phalanx cells. In this study, the changes in cerebral angiogenesis and the characteristics of angiogenesis in the prefrontal cortex of Alzheimer's disease (AD) mice were investigated. AD was induced by injection of β-amyloid into the hippocampus. The animals underwent cognitive testing, and their brains were analyzed using immunohistochemical techniques to evaluate angiogenesis. The results showed an increase in the proliferation of endothelial cells and altered ratio of tip, stalk, and phalanx cells. Vascular branching and density in the prefrontal cortex were decreased, indicating an unproductive form of angiogenesis in AD. Obtained results highlight the link between changes in angiogenesis and cognitive decline, confirming the importance of vascular dysfunction in AD progression.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"371-375"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Changes in MicroRNAs in Blood Serum and Lymph after Photodynamic Therapy in Experimental Breast Cancer. 实验性乳腺癌光动力治疗后血清和淋巴中microrna的定量变化。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06336-8
A V Kabakov, O V Kazakov, A F Poveshchenko, V N Cherkas, V V Kononchuk, T S Kalinina, N R Bodrova
{"title":"Quantitative Changes in MicroRNAs in Blood Serum and Lymph after Photodynamic Therapy in Experimental Breast Cancer.","authors":"A V Kabakov, O V Kazakov, A F Poveshchenko, V N Cherkas, V V Kononchuk, T S Kalinina, N R Bodrova","doi":"10.1007/s10517-025-06336-8","DOIUrl":"10.1007/s10517-025-06336-8","url":null,"abstract":"<p><p>The study examined the quantitative variations in the levels of pro-oncogenic miRNAs (miRNA-21, miRNA-27a, and miRNA-221) and tumor-suppressive miRNA-429 in blood serum and lymph of female Wistar rats with breast cancer after photodynamic therapy and controls (without treatment). The levels of pro-oncogenic miRNA-21 and miRNA-221 in the blood serum and lymph increased in the control group. Photodynamic therapy significantly reduced the levels of these miRNAs, suggesting the effectiveness of the treatment. The levels of pro-oncogenic miRNA-27a in the blood serum and lymph of both groups were multidirectional. The levels of tumor-suppressing miRNA-429 decreased significantly in the control group and remained low after photodynamic therapy. Therefore, miRNA-21 and miRNA-221 in the blood serum and lymph can be used as markers of the effectiveness of photodynamic therapy.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"360-362"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6 Mice. 髓肽MP5对C57BL/6小鼠成瘾性记忆消退海马突触可塑性的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06323-z
N A Beregovoy, G K Volcho, M V Starostina
{"title":"Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6 Mice.","authors":"N A Beregovoy, G K Volcho, M V Starostina","doi":"10.1007/s10517-025-06323-z","DOIUrl":"10.1007/s10517-025-06323-z","url":null,"abstract":"<p><p>The rapid formation and high stability of addictive memory are the main causes of frequent relapse of alcohol and drug diseases, which limits the possibility of complete recovery and necessitates the search for ways to disrupt the formation or enhance the extinction of addictive memory. The present work shows that myelopeptide MP5 accelerates the extinction of morphine-induced conditioned place preference in C57BL/6 mice and supports synaptic plasticity in the hippocampus, while MP2 produced no such effects.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"291-294"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Effect of Recombinant Human Angiogenin on the Functional Properties of EA.Hy926 Endothelial Cells and Human Skin Fibroblasts In Vitro. 体外评价重组人血管生成素对EA.Hy926内皮细胞和人皮肤成纤维细胞功能特性的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06338-6
A P Lykov, A M Goryachkin, M A Surovtseva, M N Drovosekov, O V Poveshchenko
{"title":"Evaluation of the Effect of Recombinant Human Angiogenin on the Functional Properties of EA.Hy926 Endothelial Cells and Human Skin Fibroblasts In Vitro.","authors":"A P Lykov, A M Goryachkin, M A Surovtseva, M N Drovosekov, O V Poveshchenko","doi":"10.1007/s10517-025-06338-6","DOIUrl":"10.1007/s10517-025-06338-6","url":null,"abstract":"<p><p>We studied the effects of recombinant human angiogenin on in vitro proliferation, migration, apoptosis, and secretion of human skin fibroblasts (FB) and endothelial cells (EC; EA.Hy926). The most potent stimulation of migration and proliferation of EC and FB was observed at angiogenin concentration of 125 ng/ml in a serum-free medium. Angiogenin had little effect on apoptosis/necrosis of EC and FB. It promoted IL-1β production by EC in a serum-free medium and did not affect FB. Angiogenin had the opposite effects on the production of TNFα and IL-10 by cells: it suppressed the production of these factors by EC in a serum-free medium and enhanced their production by FB in media with and without serum. In a serum-free medium, VEGF production by EC increased and by FB drops. NO production by EC in response to angiogenin stimulation did not depend on the culturing conditions, while NO production by FB increased in complete culture media. Thus, the presence of FCS in the culture medium considerably modulated the effect of angiogenin.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"367-370"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specific Features of the Chromosomal Composition of the Micronuclei in Women Living under Chronic Radiation Exposure. 慢性辐射照射下妇女微核染色体组成的特殊特征。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06337-7
Yu R Akhmadullina
{"title":"Specific Features of the Chromosomal Composition of the Micronuclei in Women Living under Chronic Radiation Exposure.","authors":"Yu R Akhmadullina","doi":"10.1007/s10517-025-06337-7","DOIUrl":"10.1007/s10517-025-06337-7","url":null,"abstract":"<p><p>Chromosomal composition of micronuclei of phytohemagglutinin-stimulated peripheral blood T lymphocytes in women chronically exposed to radiation due to their residence in the Techa riverside settlements in the Sothern Urals (mean age 76.4±1.2 years, mean cumulative dose for the red bone marrow 1.4±0.3 Gy) was analyzed using the cytochalasin-block micronucleus assay and multicolor fluorescent in situ hybridization (mFISH). Exposed women demonstrated an increase in the number of chromosomes eliminated from cell nucleus, but the frequency of micronuclei did not differ from that in the comparison group. High variability of the frequency of micronuclei was also noted in the group of exposed women. In all the women, X-chromosome and autosomes 2, 16 were significantly more often eliminated than other chromosomes.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"363-366"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Model of Combination Therapy of Lewis Lung Carcinoma using Resection and Cytostatics. Lewis肺癌切除加细胞抑制剂联合治疗的模型。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-14 DOI: 10.1007/s10517-025-06343-9
N N Ermakova, E G Skurikhin, I L Zharkikh, M A Zhukova, V Yu Pan, E S Pan, M Yu Minakova, S G Morozov, A A Kubatiev, A M Dygai
{"title":"A Model of Combination Therapy of Lewis Lung Carcinoma using Resection and Cytostatics.","authors":"N N Ermakova, E G Skurikhin, I L Zharkikh, M A Zhukova, V Yu Pan, E S Pan, M Yu Minakova, S G Morozov, A A Kubatiev, A M Dygai","doi":"10.1007/s10517-025-06343-9","DOIUrl":"10.1007/s10517-025-06343-9","url":null,"abstract":"<p><p>We propose a model of combination treatment of Lewis lung carcinoma (LLC) in C57BL/6 mice that includes tumor resection and chemotherapy. A single injection of 5×106 LLC cells into the right lateral subcostal region caused the growth of the primary tumor and its metastasis to the lung. For reducing metastasis and mortality after resection, the primary tumor should be removed with subcutaneous fat on day 8 after inoculation. Antitumor and antimetastatic effects and reduced mortality were achieved by intraperitoneal injection of carboplatin (63.3 mg/kg) and paclitaxel (13.3 mg/kg); chemotherapy was administered twice. The combination of the two approaches increased the survival: the antitumor and antimetastatic effects were observed in 60% of mice with LLC relative to resection alone or treatment with cytostatics alone. However, chemoresistance was formed in 40% of mice, the values of the tumor growth inhibition index and the metastasis inhibition index decreased. This was accompanied by the appearance of cancer stem cells in the circulation with the potential for the formation of spheroids in vitro. The presented model (combination of tumor resection and chemotherapy) can be used in the development of new approaches to improve treatment efficiency in patients with lung cancer.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"393-398"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of α1-Adrenergic Receptors in the Regulation of Electrical Activity of Right Atrial Myocardiocytes from 21-Day-Old Rats. α1-肾上腺素能受体在21日龄大鼠右心房心肌细胞电活动调控中的作用。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06322-0
N Mansour, A L Zefirov, N I Ziyatdinova, A M Kuptsova, T L Zefirov
{"title":"The Role of α<sub>1</sub>-Adrenergic Receptors in the Regulation of Electrical Activity of Right Atrial Myocardiocytes from 21-Day-Old Rats.","authors":"N Mansour, A L Zefirov, N I Ziyatdinova, A M Kuptsova, T L Zefirov","doi":"10.1007/s10517-025-06322-0","DOIUrl":"10.1007/s10517-025-06322-0","url":null,"abstract":"<p><p>We studied the influence of the α<sub>1</sub>-adrenergic receptor agonist methoxamine on the frequency of spontaneous activity and the parameters of electrical activity of the atrial myocardium from 21-day-old rats with normal sinus (preserved sinus node) or paced rhythm. Stimulation with methoxamine increased the frequency of spontaneous activity. Under the conditions of preserved sinus rhythm, the α<sub>1</sub>-adrenergic agonist decreased the duration of the repolarization phase of the action potential, whereas at paced rhythm, this parameter increased.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"287-290"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and Behavioral Comparison of Two Mouse Models of Cerebral Palsy. 两种脑瘫小鼠模型的构建及行为学比较。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-06 DOI: 10.1007/s10517-025-06320-2
Y Tang, Y Li, S Lin, W Wei, H Chen
{"title":"Construction and Behavioral Comparison of Two Mouse Models of Cerebral Palsy.","authors":"Y Tang, Y Li, S Lin, W Wei, H Chen","doi":"10.1007/s10517-025-06320-2","DOIUrl":"10.1007/s10517-025-06320-2","url":null,"abstract":"<p><p>Cerebral palsy (CP) is the most common neuromuscular disorder in children with no effective therapeutic methods. To examine CP, a large variety of methods and animal models was developed, the most popular are the hypoxic-ischemic (HI) injury and/or LPS injection in mice. In the presented work, HI and LPS were applied on the postnatal day 9 to humanized immunodeficiency mouse pups, thereupon 3 behavioral tests were performed in 8 weeks later. Both HI and LPS caused significant behavioral deficits assessed in the Rotarod test. In gait dynamics and open-field tests, HI and LPS caused significant behavioral deficits reported by some parameters, and the effect of HI was more severe. Additionally, HI and LPS produced the different effects on gait dynamics of the fore and hind paws. Thus, both HI and LPS induced the behavioral disorders in mice, but HI was more suitable for the development of humanized immunodeficiency mouse model of CP.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 2","pages":"273-279"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Levels of MiR-21, MiR-27a, MiR-221, and MiR-429 in the Thymus after Photodynamic Therapy and Surgical Treatment of Breast Cancer in Female Wistar Rats. 雌性Wistar大鼠乳腺癌光动力治疗和手术治疗后胸腺中MiR-21、MiR-27a、MiR-221和MiR-429水平的变化
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-07 DOI: 10.1007/s10517-025-06313-1
O V Kazakov, A V Kabakov, A F Poveshchenko, V N Cherkas
{"title":"Changes in Levels of MiR-21, MiR-27a, MiR-221, and MiR-429 in the Thymus after Photodynamic Therapy and Surgical Treatment of Breast Cancer in Female Wistar Rats.","authors":"O V Kazakov, A V Kabakov, A F Poveshchenko, V N Cherkas","doi":"10.1007/s10517-025-06313-1","DOIUrl":"10.1007/s10517-025-06313-1","url":null,"abstract":"<p><p>We studied the expression levels of microRNAs (miR-21, miR-27a, miR-221, and miR-429) in the thymus of female Wistar rats after surgical treatment of breast cancer (BC) and after photodynamic therapy for BC followed by tumor resection. In the group without treatment, the levels of pro-oncogenic miR-21, miR-27a, and miR-221 in the thymus were reduced in comparison with those in the group of intact control. After surgical treatment of BC, the levels of miR-21 and miR-27a in the thymus increased in comparison with those in BC without treatment. Surgical removal of the tumor followed by photodynamic therapy led to an even greater increase in the levels of miR-21 and miR-27a in the thymus in comparison with those in the group of surgical treatment alone. Expression of the tumor-suppressive miR-429 in the thymus significantly exceeds the levels in the BC without treatment and BC+surgery groups.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"233-236"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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