Bulletin of Experimental Biology and Medicine最新文献_第9页

Total and Reduced Aminothiols in Blood Plasma as Biochemical Markers of the Effectiveness of Hemodialysis Therapy in Patients with End-Stage Renal Disease. 血浆总氨基硫醇和还原性氨基硫醇作为终末期肾病患者血液透析治疗效果的生化指标

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-19 DOI: 10.1007/s10517-025-06328-8

S G Dzugkoev, F S Dzugkoeva, V A Gadieva

引用次数: 0

Role of β-Adrenergic Receptors in Stress-Induced Cardiac Injury. β-肾上腺素能受体在应激性心脏损伤中的作用。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06327-9

A A Boshchenko, B K Kurbatov, M Kilin, L N Maslov, N V Naryzhnaya, V V Saushkin, K V Zavadovsky, I V Stepanov, S V Gusakova, Yu G Birulina, T N Zaitseva, L V Smagliy

引用次数: 0

The Effect of α₂-Adrenergic Receptor Stimulation on the Isolated Hearts from Rats with Acute Myocardial Infarction against the Background of I_f Blockade. α2-肾上腺素能受体刺激对If阻断大鼠离体心肌梗死的影响。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06324-y

N I Ziyatdinova, A M Kuptsova, L I Faskhutdinov, R R Shakirov, T L Zefirov

{"title":"The Effect of α2-Adrenergic Receptor Stimulation on the Isolated Hearts from Rats with Acute Myocardial Infarction against the Background of If Blockade.","authors":"N I Ziyatdinova, A M Kuptsova, L I Faskhutdinov, R R Shakirov, T L Zefirov","doi":"10.1007/s10517-025-06324-y","DOIUrl":"10.1007/s10517-025-06324-y","url":null,"abstract":"We studied the effect of α2-adrenoreceptor stimulation after preliminary If blockade on the function of the Langendorff-isolated rat heart in the acute stage of experimental myocardial infarction. Stimulation of α2-adrenoreceptors with clonidine (10-6 M) against the background of If blockade with ZD7288 (10-9 M) reduced the contractility of the left ventricular myocardium, HR, coronary blood flow, and the duration of the left ventricular myocardium contraction in sham-operated rats and animals with acute myocardial infarction. The duration of relaxation and contraction cycle during α2-adrenoreceptor stimulation after preliminary If blockade (10-9 M) was increased in sham-operated rats and in animals with acute myocardial infarction. Stimulation of adrenoreceptors against the background of application of ZD7288 in a concentration of 10-5 M decreased the left ventricular pressure, HR, coronary blood flow, and the duration of left ventricular myocardial contraction in both groups. The duration of the relaxation and contraction cycle during α2-adrenoreceptor stimulation against the background of If blockade (10-5 M) increased in sham-operated rats and animals with acute myocardial infarction.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"295-300"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Soybean Trypsin Inhibitor on Biochemical Parameters of the Blood under Conditions of Water and Food Deprivation in Rats. 大豆胰蛋白酶抑制剂对水、食物剥夺大鼠血液生化指标的影响。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06329-7

I V Kuzmina, S M Tolpygo, B B Shoibonov, N V Ovchinnikova

引用次数: 0

MRI Study of the Brain Structural Characteristic in Persecutory Delusions. 迫害性妄想症脑结构特征的MRI研究。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06340-y

A S Tomyshev, A N Dudina, E V Ilina, P G Iuzbashian, E I Voronova, M M Magomedagaev, G P Kostyuk, A V Andriushchenko, D V Romanov, A B Smulevich, I S Lebedeva

引用次数: 0

Effect of Breathing a Krypton-Oxygen Mixture on Signaling Cascades in Rat Brain during Simulation of Photoinduced Ischemic Stroke. 呼吸氪氧混合物对模拟光致缺血性脑卒中大鼠脑内信号级联的影响。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-15 DOI: 10.1007/s10517-025-06332-y

V V Antonova, I V Shumov, V T Dolgikh, A A Grebenchikova, M V Gabitov, E I Yakupova, O A Grebenchikov

引用次数: 0

Comparative Assessment of Pharmacokinetic Parameters of Mexidol after Intravenous Administration of Liposomal Emulsion and Aqueous Solution to Rats. 大鼠静脉注射墨西多脂质体乳剂和水溶液后药动学参数的比较研究。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06331-z

V S Shindyaikina, A V Siprov, V I Inchina, I A Gololobova, V I Shlyapkina, O A Kulikov

{"title":"Comparative Assessment of Pharmacokinetic Parameters of Mexidol after Intravenous Administration of Liposomal Emulsion and Aqueous Solution to Rats.","authors":"V S Shindyaikina, A V Siprov, V I Inchina, I A Gololobova, V I Shlyapkina, O A Kulikov","doi":"10.1007/s10517-025-06331-z","DOIUrl":"10.1007/s10517-025-06331-z","url":null,"abstract":"We compared the pharmacokinetic parameters of liposomal emulsion and aqueous solution of Mexidol after intravenous injection to rats at a dose of 50 mg/kg. The concentrations of Mexidol in blood plasma and homogenates of the lungs, liver, kidneys, testes, and ovaries were measured 30, 60, 120, 240 min, 24 and 48 h after administration by HPLC. The liposomal Mexidol in contrast to its aqueous solution quickly disappeared from systemic circulation (a 5-fold decrease in plasma concentration was noted as soon as 4 h after administration) and was predominantly absorbed and retained for a longer period by the liver and lungs: after 24 h, the concentration of liposomal Mexidol exceeded that of its water-soluble form by 14.2 times in the liver and by 63% in the lungs. In the testes, the concentration of liposomal Mexidol exceeded that of its water-soluble form during the first 4 h postinjection: by 4 times after 1 h and by 2 times after 4 h, whereas in the ovarian tissues, the same concentrations were observed after administration of liposomal and water-soluble forms. In the gonadal tissues, the water-soluble form of Mexidol was retained longer than its liposomal form.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"327-332"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between Genes and microRNAs Involved in the Migration of Cells from the Bone Marrow during Experimental Liver Fibrosis. 实验性肝纤维化过程中参与骨髓细胞迁移的基因与microrna的关系。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06335-9

E I Lebedeva, A T Shchastniy, A S Babenka, D A Zinovkin, E A Nadyrov

{"title":"Relationship between Genes and microRNAs Involved in the Migration of Cells from the Bone Marrow during Experimental Liver Fibrosis.","authors":"E I Lebedeva, A T Shchastniy, A S Babenka, D A Zinovkin, E A Nadyrov","doi":"10.1007/s10517-025-06335-9","DOIUrl":"10.1007/s10517-025-06335-9","url":null,"abstract":"Progressive toxic liver fibrosis in Wistar male rats was characterized by the migration of CX3CR1+ and CD34+ cells from the bone marrow, accompanied by a mild increase in their numbers. From weeks 3 to 5 and 9 to 13, the number of CX3CR1+ cells remained approximately the same. The area occupied by CD34+ cells increased by 2 times (p<0.001) only by the end of the experiment. At week 3, the correlation between Cxcl12 and Notch2 mRNA was lost, while at week 9, a correlation of Cxcl12 with Notch1 and Notch2 was observed. From week 11 onwards, a correlation of Cxcl12 with Notch2 was revealed and a correlation with Notch1 disappeared. miR-3558-3p was correlated with Cxcl12 mRNA level at the stages of progressive fibrosis and nodular remodeling of the liver parenchyma. The greatest number of miRNAs showed direct and inverse correlations of moderate to medium strength, with Cxcl12 gene at the stage of complete cirrhosis. The mRNA levels of Cxcl12 and Yap1 showed a significant correlation with each other throughout the experiment. This suggests that they may be involved in the process of cell migration from the bone marrow to the liver and play a role in fibrosis and cirrhosis. They could be considered as potential targets for the development of new treatments.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"351-359"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and Molecular Biological Changes in the Hippocampus and Prefrontal Cortex of the Brain of Newborn Male and Female Wistar Rats after LPS-Induced Activation of the Maternal Immune Response. lps诱导的母体免疫应答激活后新生雄性和雌性Wistar大鼠海马和前额叶皮层的形态学和分子生物学变化

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06341-x

A S Lyamtsev, A V Sentyabreva, I S Tsvetkov, E A Miroshnichenko, A M Kosyreva

{"title":"Morphological and Molecular Biological Changes in the Hippocampus and Prefrontal Cortex of the Brain of Newborn Male and Female Wistar Rats after LPS-Induced Activation of the Maternal Immune Response.","authors":"A S Lyamtsev, A V Sentyabreva, I S Tsvetkov, E A Miroshnichenko, A M Kosyreva","doi":"10.1007/s10517-025-06341-x","DOIUrl":"10.1007/s10517-025-06341-x","url":null,"abstract":"Infectious and inflammatory processes during pregnancy in women provoke maternal immunity activation (MIA) and increase the risk of neuropsychiatric disorders in children. These disorders can lead to neurodegenerative diseases later in life. To study these effects, we evaluated the morphological and molecular biological changes in the hippocampus and prefrontal cortex of male and female Wistar rats on the 1st day of postnatal ontogenesis after LPS-induced MIA. The level of calprotectin in the blood serum of postpartum rats, the number and morphological properties of microglial cells in the hippocampus, and the expression of proinflammatory, stem, and adaptation markers in fragments of the prefrontal cortex in offspring of both sexes were determined. It was found that LPS-induced MIA had a negative effect on the developing offspring, with an increase in the level of expression of Nfκb and App in the prefrontal cortex of newborns being observed. Sex differences in morphological and molecular biological changes in the brains of newborn Wistar rats were also revealed: the number of microglial cells increased in male rats, while the number of ramified microglial cells decreased in female rats. In addition, only in females, the expression levels of the mRNA markers for stem cells, Sox2 and Sox9, decreased, while the expression level of Hif1α, which has a neuroprotective effect, increased only in males. These data may explain the differences in the incidence of neurodegenerative diseases among elderly patients of different sexes.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"381-386"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Sensitivity of Opportunistic Bacteria to Blood Serum Low-Molecular Fraction Containing Antimicrobial Peptides and Proteins. 条件细菌对含抗菌肽和蛋白的血清低分子组分的敏感性。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06333-x

A M Iksanova, I M Ojovan, V G Arzumanian, N O Vartanova, A V Poddubikov, T I Kolyganova, S Yu Konanykhina

引用次数: 0