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Analysis of Antibiotic Susceptibility of Lactobacillus Strains Isolated from Adolescent Gut Microbiota. 青少年肠道菌群乳酸菌的药敏分析。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06687-w
N E Smurova, A S Gorkavenko, R E Zugeeva, N L Belkova, N N Chemezova, I G Kondratov, E S Klimenko, N V Semenova, L V Rychkova
{"title":"Analysis of Antibiotic Susceptibility of Lactobacillus Strains Isolated from Adolescent Gut Microbiota.","authors":"N E Smurova, A S Gorkavenko, R E Zugeeva, N L Belkova, N N Chemezova, I G Kondratov, E S Klimenko, N V Semenova, L V Rychkova","doi":"10.1007/s10517-026-06687-w","DOIUrl":"10.1007/s10517-026-06687-w","url":null,"abstract":"<p><p>The phenotypic antibiotic susceptibility was determined for 46 Lactobacillus strains isolated from the gut microbiota of healthy adolescents and considered as candidate probiotics. All tested strains were susceptible to amoxicillin. Most Lactobacillus strains demonstrated susceptibility (some of them only upon extended exposure) to tetracycline, clindamycin, erythromycin, chloramphenicol, and ampicillin. Resistance to penicillins is a characteristic feature of many Lactobacillus spp., but only 27 tested strains showed phenotypic resistance to oxacillin. Plasmid DNA was detected in eight of the 46 strains. None of the tested strains harbored the transmissible antibiotic resistance genes tetW, cat-TC, and ermC in either genomic or plasmid DNA. The results allowed identifying strains susceptible to the tested antibiotics, but further genetic analysis is required to confirm their safety profile.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"618-621"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidepressant Activity of 11-Dialkylaminoethyl-2,3,4,5-tetrahydrodiazepino[1,2-a]benzimidazole Derivative DAB-21 in a Model of Chronic Unpredictable Mild Stress. 11-二烷基氨基乙基-2,3,4,5-四氢二氮平[1,2-a]苯并咪唑衍生物DAB-21在慢性不可预测轻度应激模型中的抗抑郁活性。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06684-z
M O Maltseva, D V Maltsev, M V Miroshnikov, L A Smirnova, L N Divaeva, A S Morkovnik, A A Spasov
{"title":"Antidepressant Activity of 11-Dialkylaminoethyl-2,3,4,5-tetrahydrodiazepino[1,2-a]benzimidazole Derivative DAB-21 in a Model of Chronic Unpredictable Mild Stress.","authors":"M O Maltseva, D V Maltsev, M V Miroshnikov, L A Smirnova, L N Divaeva, A S Morkovnik, A A Spasov","doi":"10.1007/s10517-026-06684-z","DOIUrl":"10.1007/s10517-026-06684-z","url":null,"abstract":"<p><p>The antidepressant properties of DAB-21 a compound with anxiolytic activity, were studied in C57BL/6 mice after modeling chronic unpredictable mild stress. In the Porsolt swim and tail suspension tests, the effect of DAB-21 was similar to that of amitriptyline, imipramine, and fluoxetine. In the open field test, the substance did not stimulate the motor activity of animals, which excludes the pseudo-antidepressant effect. HPLC analysis of monoamines and their metabolites in the frontal cortex showed that the 5-HIAA/serotonin ratio in animals treated with DAB-21 was 0.1, which is closest to that in the fluoxetine group. These findings suggest that the anxiolytic and antidepressant effects of DAB-21 are mediated via the serotonergic pathway.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"603-608"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Mitochondrial Transition Pore in the Realization of the Cardioprotective Effect of Probiotic Strains in Systemic Inflammatory Response in Rats. 线粒体过渡孔在益生菌菌株在大鼠全身炎症反应中实现心脏保护作用中的作用。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06677-y
Y Y Borshchev, S M Minasyan, I Y Burovenko, V Y Borshchev, A D Gordeev, O V Borshcheva, M M Galagudza
{"title":"The Role of Mitochondrial Transition Pore in the Realization of the Cardioprotective Effect of Probiotic Strains in Systemic Inflammatory Response in Rats.","authors":"Y Y Borshchev, S M Minasyan, I Y Burovenko, V Y Borshchev, A D Gordeev, O V Borshcheva, M M Galagudza","doi":"10.1007/s10517-026-06677-y","DOIUrl":"10.1007/s10517-026-06677-y","url":null,"abstract":"<p><p>The study tested the hypothesis of the involvement of the mitochondrial transition pore (MTP) in the cardioprotective effect of probiotics under conditions of a systemic inflammatory response (SIR) in rats. After the induction of SIR, Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis were administered orally to rats for 7 days. The MTP blocker cyclosporine A was injected intravenously at a dose of 10 mg/kg 20 min before the start of the isolated heart perfusion using the Langendorff technique. Global 30-min ischemia followed by 90-min reperfusion was modeled, after which the size of the necrosis zone was measured. In the SIR groups, the size of the necrosis zone was significantly greater than in the control (61 (57; 64)% vs (35 (35; 37)%; p < 0.05); an increase in the levels of proinflammatory cytokines and leukocytosis was also noted. In rats treated with probiotics, the size of the necrosis zone were smaller than in the SIR group (47 (34; 52)%; p < 0.05). Injection of MTP blocker cyclosporine A partially abolished the cardioprotective effect of probiotics (the size of the necrosis zone was 54 (50; 55)%; p < 0.05), which indicates the involvement of MTP opening in the mechanisms of probiotic cardioprotection.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"567-570"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histomorphometric Evaluation of the Tissue Response to Xenogeneic Extracellular Peritoneal Matrix and Synthetic UltraPro Mesh under Conditions of Pseudomonas aeruginosa Infection. 铜绿假单胞菌感染条件下组织对异种细胞外腹膜基质和合成超超网状物反应的组织形态学评价。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06693-y
N T Abatov, R M Badyrov, N K Urazbayev, E K Kamyshanskiy, A V Lavrinenko, L L Akhmaltdinova, D K Esniyazov
{"title":"Histomorphometric Evaluation of the Tissue Response to Xenogeneic Extracellular Peritoneal Matrix and Synthetic UltraPro Mesh under Conditions of Pseudomonas aeruginosa Infection.","authors":"N T Abatov, R M Badyrov, N K Urazbayev, E K Kamyshanskiy, A V Lavrinenko, L L Akhmaltdinova, D K Esniyazov","doi":"10.1007/s10517-026-06693-y","DOIUrl":"10.1007/s10517-026-06693-y","url":null,"abstract":"<p><p>We performed a comparative histomorphometric assessment of the tissue responses to two types of implants, xenogeneic extracellular peritoneal matrix (ECM) and synthetic UltraPro mesh, in laboratory rats with modeled Pseudomonas aeruginosa infection. Histological evaluation was carried out on days 10 and 20 after implantation of the tested materials under the anterior abdominal wall. ECM induced a pronounced inflammatory response accompanied by tissue necrosis at early post-implantation terms and followed by progressive tissue remodeling. In contrast, the UltraPro mesh induced a milder acute inflammatory reaction with a tendency toward chronic inflammation and fibrous capsule formation. This findings support the importance of evaluating the infectious burden during implant selection in clinical practice.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"649-654"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Antitubercular Drug Macozinone (PBTZ169) on the Intestinal Microbiota and Immunity in Inbred Mice. 抗结核药Macozinone （PBTZ169）对近交系小鼠肠道菌群和免疫力的影响。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06685-y
B V Nikonenko, I V Bocharova, A E Donnikov, S I Kajukova, D V Dianov, V A Makarov
{"title":"Effect of Antitubercular Drug Macozinone (PBTZ169) on the Intestinal Microbiota and Immunity in Inbred Mice.","authors":"B V Nikonenko, I V Bocharova, A E Donnikov, S I Kajukova, D V Dianov, V A Makarov","doi":"10.1007/s10517-026-06685-y","DOIUrl":"10.1007/s10517-026-06685-y","url":null,"abstract":"<p><p>Inbred BALB/c mice were intragastrically administered with a new antitubercular compound macozinone (PBTZ169) or a combination of isoniazid, rifampicin, and pyrazinamide (HRZ) for six months; control animals received no antitubercular drugs. After 6 months, the microbiota of the large intestine was analyzed. Unlike HRZ combination, macozinone practically does not affect the microbiota: its composition remained the same as in the control group. In lung tissue, differences in the expression of some genes regulating the immune response were found. Two months post-infection with Mycobacterium tuberculosis, mice treated with either the HRZ combination or macozinone exhibited distinct immune responses to tuberculin.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"609-613"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating DNA-Markers of High Risk for Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease. 慢性阻塞性肺疾病患者高危肺癌循环dna标记物
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06691-0
A A Ponomaryova, V V Boyarko, L Wang, Z Huang, A A Korobeynikova, P A Gervas, D V Kapitanova, E B Bukreeva, O V Pancova, A A Zarubin, V M Perelmuter, N V Cherdyntseva, E V Denisov
{"title":"Circulating DNA-Markers of High Risk for Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease.","authors":"A A Ponomaryova, V V Boyarko, L Wang, Z Huang, A A Korobeynikova, P A Gervas, D V Kapitanova, E B Bukreeva, O V Pancova, A A Zarubin, V M Perelmuter, N V Cherdyntseva, E V Denisov","doi":"10.1007/s10517-026-06691-0","DOIUrl":"10.1007/s10517-026-06691-0","url":null,"abstract":"<p><p>In 26 patients with chronic obstructive pulmonary disease (COPD), validation of the marker genes RARB, ZNF260, and DCDC1 was carried out using liquid biopsy technology. Hypermethylation of RARB, ZNF260, and DCDC1 genes in extracellular DNA of the blood plasma was revealed. Post-therapeutic monitoring showed that hypermethylation of the RARB and/or ZNF260 genes was associated with the development of lung cancer in 23% of cases. These findings show the potential of analyzing the epigenetic markers for assessing the risk of lung cancer development in COPD patients.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"642-648"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of Anxiolytic Properties of Diterpene Alkaloid 12-Epinapelline N-Oxide. 二萜生物碱12-环氧肾上腺碱抗焦虑性的研究。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06683-0
Yu V Nesterova, O V Vsyakikh, T N Povetyeva, N I Suslov, P V Kulpin, G N Zyuz'kov, V V Zhdanov
{"title":"Study of Anxiolytic Properties of Diterpene Alkaloid 12-Epinapelline N-Oxide.","authors":"Yu V Nesterova, O V Vsyakikh, T N Povetyeva, N I Suslov, P V Kulpin, G N Zyuz'kov, V V Zhdanov","doi":"10.1007/s10517-026-06683-0","DOIUrl":"10.1007/s10517-026-06683-0","url":null,"abstract":"<p><p>Diterpenoid alkaloid 12-epinapelline N-oxide exhibited pronounced anxiolytic activity comparable to that of phenazepam in the open field and elevated plus maze tests. Unlike the benzodiazepine anxiolytic, course administration of the alkaloid did not cause cognitive impairment in experimental animals.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"598-602"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Various Modes of Intermittent Normobaric Hypoxia on the Neurological and Hormonal Status of Rats. 不同模式间歇常压缺氧对大鼠神经和激素状态的影响。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06674-1
K A Baranova, M V Osipova, E A Rybnikova
{"title":"The Effect of Various Modes of Intermittent Normobaric Hypoxia on the Neurological and Hormonal Status of Rats.","authors":"K A Baranova, M V Osipova, E A Rybnikova","doi":"10.1007/s10517-026-06674-1","DOIUrl":"10.1007/s10517-026-06674-1","url":null,"abstract":"<p><p>Hypoxic conditioning (HC) is a novel approach that employs intermittent hypoxia for health and wellness purposes, fundamentally differing from the well-known method of hypoxic training (HT). We compared the effects of various modes of HC and HT on the neurological and antioxidant status and the function of the hypothalamic-pituitary-adrenocortical axis and thyroid systems in rats. It was found that HC had a more beneficial effect on the nervous system, which was accompanied by a transient decrease in antioxidant activity in the hippocampus and an increase in blood glucocorticoid levels on the first day. HT inhibited the thyroid function, while conditioning regimens produced a less pronounced effect.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"555-558"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood Plasma Cytokine Concentration in Female Rats with Temporomandibular Joint Osteoarthritis. 雌性颞下颌关节骨性关节炎大鼠血浆细胞因子浓度变化。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06676-z
V D Vinnikova, O S Pak, I V Vorozhko, T N Korotkova, A V Klimenko, A Yu Abramova, S S Pertsov
{"title":"Blood Plasma Cytokine Concentration in Female Rats with Temporomandibular Joint Osteoarthritis.","authors":"V D Vinnikova, O S Pak, I V Vorozhko, T N Korotkova, A V Klimenko, A Yu Abramova, S S Pertsov","doi":"10.1007/s10517-026-06676-z","DOIUrl":"10.1007/s10517-026-06676-z","url":null,"abstract":"<p><p>Plasma concentrations of some cytokines were analyzed in female rats at different time points (on days 14 and 28) after induction of temporomandibular joint osteoarthritis via injection of sodium monoiodoacetate. Under these conditions, the concentrations of IL-6 and IL-10 in animals with temporomandibular joint dysfunction were lower than in intact animals at both the relatively early (day 14) and late (day 28) stages of observation. The level of TNFα in rats with experimental arthritis at the later stage of the study was higher than at the early stage. The observed changes may reflect a compensatory adjustment of immune mechanisms aimed at limiting the inflammatory response at different stages of its development.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"563-566"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of α2-Adrenergic Receptor Stimulation on Isolated Rat Heart during Puberty after Hypokinesia. α - 2肾上腺素能受体刺激对青春期运动不足大鼠离体心脏的影响。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06675-0
M I Sungatullina, R I Zaripova, A M Sadykov, A L Zefirov, N I Ziyatdinova, T L Zefirov
{"title":"Effect of α<sub>2</sub>-Adrenergic Receptor Stimulation on Isolated Rat Heart during Puberty after Hypokinesia.","authors":"M I Sungatullina, R I Zaripova, A M Sadykov, A L Zefirov, N I Ziyatdinova, T L Zefirov","doi":"10.1007/s10517-026-06675-0","DOIUrl":"10.1007/s10517-026-06675-0","url":null,"abstract":"<p><p>We studied the effect of α<sub>2</sub>-adrenoreceptor stimulation on functional parameters of Langendorff-isolated heart from pubertal rats subjected to restriction of motor activity during the early postnatal ontogeny. Clonidine hydrochloride, an agonist of α<sub>2</sub>-adrenoreceptors, was used at concentrations of 10<sup>-9</sup>-10<sup>-6</sup> M. After restriction of motor activity, stimulation of α<sub>2</sub>-adrenoreceptors with clonidine at the studied concentrations had a positive inotropic effect. α<sub>2</sub>-Adrenoreceptor stimulation led to a dose-dependent decrease in coronary flow, and this effect was more pronounced after hypokinesia. The role of α<sub>2</sub>-adrenoreceptors in the cardiovascular system under conditions of motor restriction requires further study considering age-related features.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"559-562"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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