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Therapeutic Effects of Bacteroides fragilis Vesicles in a Model of Chemically Induced Colitis in Rats. 脆弱拟杆菌囊泡对化学药物诱导的大鼠结肠炎模型的治疗作用
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-30 DOI: 10.1007/s10517-024-06237-2
O Yu Shagaleeva, D A Kashatnikova, E A Vorobyeva, D A Kardonsky, A S Silantiev, B A Efimov, V A Ivanov, Yu A Bespyatikh, N B Zakharzhevskaya
{"title":"Therapeutic Effects of Bacteroides fragilis Vesicles in a Model of Chemically Induced Colitis in Rats.","authors":"O Yu Shagaleeva, D A Kashatnikova, E A Vorobyeva, D A Kardonsky, A S Silantiev, B A Efimov, V A Ivanov, Yu A Bespyatikh, N B Zakharzhevskaya","doi":"10.1007/s10517-024-06237-2","DOIUrl":"10.1007/s10517-024-06237-2","url":null,"abstract":"<p><p>The anti-inflammatory properties of Bacteroides fragilis vesicles were studied in a rat model of dextran sodium sulfate-induced colitis. According to the histology results, addition of B. fragilis vesicles to the therapy promoted colon repair. Evaluation of the disease activity index confirms the high rate of colon recovery: against the background of vesicle administration, the absence of blood in stool, normal stool consistency, and body weight normalization were observed.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"626-629"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Effect of Dibornol on the Level of DNA Damage in the DNA Comet Test In Vivo. 评估二苯甲酮醇对体内 DNA 彗星试验中 DNA 损伤程度的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-28 DOI: 10.1007/s10517-024-06239-0
T G Borovskaya, A V Vychuzhanina, Yu A Schemerova, L A Stremlina, I Yu Chukicheva, A V Kuchin, V E Goldberg, A M Dygai
{"title":"Evaluation of the Effect of Dibornol on the Level of DNA Damage in the DNA Comet Test In Vivo.","authors":"T G Borovskaya, A V Vychuzhanina, Yu A Schemerova, L A Stremlina, I Yu Chukicheva, A V Kuchin, V E Goldberg, A M Dygai","doi":"10.1007/s10517-024-06239-0","DOIUrl":"10.1007/s10517-024-06239-0","url":null,"abstract":"<p><p>In male C57BL/6 mice (8-12 weeks) and male Wistar rats (12 weeks), the effect of dibornol (2,6-diisobornyl-4-methylphenol) on the level of spontaneous DNA damage in cells of the bone marrow, liver, kidneys, and rectum of mice (series I) and genotoxic effects in rat testicular cells after administration of cytostatic drugs with different mechanisms of action (series II) were studied using the DNA comet assay. In series I, dibornol was intragastrically administered to mice once at doses of 200, 400, and 2000 mg/kg; in series II, dibornol was intragastrically administered to rats at a dose of 10 mg/kg for 5 days before and 5 days after the cytostatic treatment (methotrexate, doxorubicin). It was found that dibornol in all studied doses did not produce the genotoxic (carcinogenic) effect and reduced the level of spontaneous DNA damage in the bone marrow. After combined administration of cytostatic drugs (doxorubicin, methotrexate) and dibornol, the level of DNA breaks was reduced to 38.5 and 49% of the control, respectively.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"635-638"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-Related Features of the Function of the Hypothalamic-Pituitary-Thyroid (HPT) Axis in Nonhuman Primates under Constant Lighting. 恒定光照下非人灵长类下丘脑-垂体-甲状腺轴（HPT）功能的年龄特征
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-28 DOI: 10.1007/s10517-024-06230-9
N D Goncharova, A M Ermolaeva, O A Chigarova, T E Oganyan, N V Timoshenko
{"title":"Age-Related Features of the Function of the Hypothalamic-Pituitary-Thyroid (HPT) Axis in Nonhuman Primates under Constant Lighting.","authors":"N D Goncharova, A M Ermolaeva, O A Chigarova, T E Oganyan, N V Timoshenko","doi":"10.1007/s10517-024-06230-9","DOIUrl":"10.1007/s10517-024-06230-9","url":null,"abstract":"<p><p>We studied the features of the functioning of the hypothalamic-pituitary-thyroid (HPT) axis under conditions of constant (4 weeks) lighting (LED lamps intended for office and residential premise) on a translational model of young adult and old female rhesus monkeys, in particular taking into account their behavior. Constant lightning had no significant effect on the levels of thyroid-stimulating hormone, thyroxine, and triiodothyronine under basal conditions in all animals, regardless of age and behavioral characteristics, but induced a decrease in thyroid function under conditions of its activation with thyrotropin-releasing hormone, mainly in old animals.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"592-597"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Innate Immunity and Microbiome in Different Aging Phenotypes. 不同衰老表型中先天性免疫和微生物组的变化
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-28 DOI: 10.1007/s10517-024-06244-3
L V Gankovskaya, O A Svitich, A V Poddubikov, V V Burmakina, E M Khasanova, S V Gorodishchenskaya
{"title":"Changes in Innate Immunity and Microbiome in Different Aging Phenotypes.","authors":"L V Gankovskaya, O A Svitich, A V Poddubikov, V V Burmakina, E M Khasanova, S V Gorodishchenskaya","doi":"10.1007/s10517-024-06244-3","DOIUrl":"10.1007/s10517-024-06244-3","url":null,"abstract":"<p><p>The indicators of innate immunity and the composition of the microbiome in the nasopharyngeal mucosa in centenarians with different aging phenotypes were analyzed. A significant increase in the expression of pattern-recognizing receptor genes (TLR2, TLR4, and NLRP3) and proinflammatory cytokines (IL1B, IL18) was shown in the group of centenarians with pathological aging phenotype. In centenarians with successful aging phenotype, increased diversity of the microbiome composition was observed. At the same time, a moderate inverse correlation was found between an increase in the growth of the commensal bacterium Streptococcus salivarius and a decrease in the expression of proinflammatory cytokine genes IL1B and IL18. These findings can serve as biomarkers for the timely identification of the phenotype of aging in senile and elderly people.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"658-661"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dominant Frequency of Ventricular Fibrillation During Ischemia and Reperfusion. 缺血和再灌注期间心室颤动的主要频率
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-28 DOI: 10.1007/s10517-024-06228-3
M I Gurianov, E A Kharitonova, P K Yablonsky
{"title":"Dominant Frequency of Ventricular Fibrillation During Ischemia and Reperfusion.","authors":"M I Gurianov, E A Kharitonova, P K Yablonsky","doi":"10.1007/s10517-024-06228-3","DOIUrl":"10.1007/s10517-024-06228-3","url":null,"abstract":"<p><p>Ventricular fibrillation (VF) in dogs is characterized by a rapid increase in its dominant frequency during the 1st minute of reperfusion followed by its decrease during the 2nd minute of reperfusion. The longer is ischemia in VF, the greater is the increase in dominant VF frequency during reperfusion. The 1st minute of reperfusion is characterized by a 1.2-fold increase in dominant VF frequency after 1-min ischemia in VF, by 1.4-fold increase after 2-min ischemia, by 2-fold increase after 3 min, and by 2.6-fold increase after 4-min ischemia. During the 2nd minute of reperfusion, the dominant VF frequency decreased by 1.1-1.3 times, and during 3rd-10th minutes of reperfusion, the dominant VF frequency is stabilized.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"584-587"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental Model of Cerebral Arterial Air Embolism in Conscious Rats. 清醒大鼠脑动脉空气栓塞实验模型
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-10-01 DOI: 10.1007/s10517-024-06246-1
V A Palikov, A N Murashev, R R Amirov, A M Ismailova, V A Kazakov, E S Sadovnikova, Yu A Palikova, I D Rubinshteyn, S O Afanasyeva, E S Mikhaylov, S G Semushina, I A Dyachenko, A T Logunov, N B Pavlov
{"title":"Experimental Model of Cerebral Arterial Air Embolism in Conscious Rats.","authors":"V A Palikov, A N Murashev, R R Amirov, A M Ismailova, V A Kazakov, E S Sadovnikova, Yu A Palikova, I D Rubinshteyn, S O Afanasyeva, E S Mikhaylov, S G Semushina, I A Dyachenko, A T Logunov, N B Pavlov","doi":"10.1007/s10517-024-06246-1","DOIUrl":"10.1007/s10517-024-06246-1","url":null,"abstract":"<p><p>In this work, an optimal air supply mode was selected to create a model of cerebral arterial air embolism (CAAE) on conscious male Sprague-Dawley rats (n=49). The efficacy of the selected model (administration of 100 μl/kg of air at a rate of 10 μl/min with an infusion pump) was determined by changes in serum biochemical parameters (cholesterol, alkaline phosphatase, inorganic phosphates, AST, and triglycerides), impaired motor functions in the Rotarod test, and visual assessment of the ischemic foci (staining of frontal sections with 1% triphenyltetrazolium chloride solution) at different terms after AAE. The model of AAE created by us confirmed impairment of coordination and motor function in conscious animals and reproduced the lethal consequences of this condition. The obtained results can serve as the basis for drug testing and the development of new approaches to the treatment of ischemic stroke.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"668-672"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of Macrophage Colony-Stimulating Factor CSF-1 in Spinal Cord Neurons in Mice with Experimental Autoimmune Encephalomyelitis. 实验性自身免疫性脑脊髓炎小鼠脊髓神经元中巨噬细胞集落刺激因子 CSF-1 的表达
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-10-01 DOI: 10.1007/s10517-024-06249-y
A V Balashov, V P Balashov, N P Shikhanov, S V Gushchina
{"title":"Expression of Macrophage Colony-Stimulating Factor CSF-1 in Spinal Cord Neurons in Mice with Experimental Autoimmune Encephalomyelitis.","authors":"A V Balashov, V P Balashov, N P Shikhanov, S V Gushchina","doi":"10.1007/s10517-024-06249-y","DOIUrl":"10.1007/s10517-024-06249-y","url":null,"abstract":"<p><p>In mice with acute and chronic models of experimental autoimmune encephalomyelitis (EAE), a quantitative study of the dynamics of CSF-1 and IL-34 protein levels in the spinal cord and blood plasma was conducted by ELISA and the specificity of CSF-1 expression in spinal cord cells was examined by immunohistological methods. A significant increase in the level of CSF-1 in the spinal cord was detected and populations of motoneurons with intense CSF-1 immunoreactivity were identified in mice with acute and chronic EAE. The obtained results suggest a possible role of CSF-1 in the pathogenesis and progression of EAE/multiple sclerosis.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"682-685"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vitro Hemocompatibility of Arabinogalactan, Betulin, and Betulin Derivatives. 阿拉伯半乳聚糖、白桦脂素和白桦脂素衍生物的体外血液相容性。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-30 DOI: 10.1007/s10517-024-06236-3
N N Drozd, S A Kuznetsova, E S Skurydina, N Yu Vasilieva, V A Levdansky
{"title":"In Vitro Hemocompatibility of Arabinogalactan, Betulin, and Betulin Derivatives.","authors":"N N Drozd, S A Kuznetsova, E S Skurydina, N Yu Vasilieva, V A Levdansky","doi":"10.1007/s10517-024-06236-3","DOIUrl":"10.1007/s10517-024-06236-3","url":null,"abstract":"<p><p>The hemocompatibility of arabinogalactan, betulin and its derivatives was evaluated in vitro and samples suitable for creation of nanostructures or materials in contact with blood were selected. The prospects of arabinogalactan as a component of the construct (nanostructure) for drug delivery are due to the fact that it did not affect blood/plasma coagulation (at concentrations of 0.0033-3.333 mg/ml and 0.00465-4.65 mg/ml, respectively), platelet aggregation (0.00182-0.182 mg/ml), and demonstrated the degree of erythrocyte hemolysis less than 3%. Sodium salt of betulin monosulfate, diarginine salt of betulin disulfate (up to 0.465 mg/ml), and especially betulin and allobetulin formate with procoagulant properties (degree of hemolysis less than 2%) can be used to create a material, for example, sponge, gel, active against blood coagulation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"621-625"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ototoxic Effect of Nicotinamide Riboside. 烟酰胺核苷的耳毒性效应
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-28 DOI: 10.1007/s10517-024-06240-7
S A Ivanov, E Yu Podyacheva, S G Zhuravskii, Ya G Toropova
{"title":"Ototoxic Effect of Nicotinamide Riboside.","authors":"S A Ivanov, E Yu Podyacheva, S G Zhuravskii, Ya G Toropova","doi":"10.1007/s10517-024-06240-7","DOIUrl":"10.1007/s10517-024-06240-7","url":null,"abstract":"<p><p>We studied the function of the auditory system in Wistar rats after repeated intravenous administration of nicotinamide riboside (NR). The functional activity of the receptor and retrocochlear parts of the auditory system were assessed by recording short-latency auditory evoked potentials (SLAEPs) and distortion-product otoacoustic emissions (DPOAEs) at baseline, immediately after NR administration, and 1 and 2 months later. Repeated intravenous NR administration (cumulative dose of 2700 mg/kg) to Wistar rats has a detrimental impact on the structures within the cochlear section of the auditory system.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"639-642"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural Features of Left Ventricle Cardiomyocytes in Preterm Newborn Rats. 早产新生大鼠左心室心肌细胞的超微结构特征
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-10-01 DOI: 10.1007/s10517-024-06247-0
V V Ivanova, O N Serebryakova, I V Sukhodolo, I V Milto
{"title":"Ultrastructural Features of Left Ventricle Cardiomyocytes in Preterm Newborn Rats.","authors":"V V Ivanova, O N Serebryakova, I V Sukhodolo, I V Milto","doi":"10.1007/s10517-024-06247-0","DOIUrl":"10.1007/s10517-024-06247-0","url":null,"abstract":"<p><p>The structure of left ventricular cardiomyocytes of 1 day preterm newborn rats was studied using transmission electron microscopy. It was shown that the relative area of the nucleus in cardiomyocytes of preterm rats is lower, and the relative area of the cytoplasm is higher than in full-term rats, while the relative areas of myofibrils and mitochondria do not differ. In cardiomyocytes of preterm rats damaged mitochondria, subsegmental myofibrillar contracture, and cytoplasmic swelling were found on the first postnatal day. Preterm birth in rats, in contrast to birth at term, is accompanied by the development of a number of ultrastructural damages in cardiomyocytes.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"673-677"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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