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Bulletin of Experimental Biology and Medicine最新文献

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Safety and Immunogenic Efficacy of Inactivated Monovalent Vaccines against Newcastle Disease in the Republic of Kazakhstan. 哈萨克斯坦共和国新城疫灭活单价疫苗的安全性和免疫原性效果。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06408-9
N Zh Akmyrzayev, N N Assanzhanova, Zh K Kydyrbayev, Sh Zh Ryskeldinova, A T Zhunushov, Ye M Kozhamkulov, A M Mailybayeva, A M Sagymbayeva, Ye T Myrzakhmetov
{"title":"Safety and Immunogenic Efficacy of Inactivated Monovalent Vaccines against Newcastle Disease in the Republic of Kazakhstan.","authors":"N Zh Akmyrzayev, N N Assanzhanova, Zh K Kydyrbayev, Sh Zh Ryskeldinova, A T Zhunushov, Ye M Kozhamkulov, A M Mailybayeva, A M Sagymbayeva, Ye T Myrzakhmetov","doi":"10.1007/s10517-025-06408-9","DOIUrl":"10.1007/s10517-025-06408-9","url":null,"abstract":"<p><p>The effectiveness of the inactivated vaccines developed by us against the Newcastle disease virus was studied in chickens after infection with a highly virulent Alatau-98 strain. The vaccines in the form of a stable water-oil emulsion were prepared using Montanide ISA 70 VG adjuvant. The immunogenicity of the vaccines was checked 7, 14, 21, and 28 days after administration. The effectiveness was determined by the ability of the vaccine preparations to protect against the disease and by mortality after infection with a highly virulent Alatau-98 strain. Inactivated vaccines developed by us have shown promising results in protecting birds from Newcastle disease and can significantly improve disease control in domestic poultry.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"739-743"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonogenic Capacity and Migration Potential of A549 and HeLa Cell Lines Survived after Acute X-Ray Irradiation at a Dose of 15 Gy. 15gy急性x射线照射后A549和HeLa细胞系的克隆生成能力和迁移潜力
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06413-y
A A Tsishnatti, S M Rodneva, Yu A Fedotov, V D Gurev, V N Belyaev, D V Guryev
{"title":"Clonogenic Capacity and Migration Potential of A549 and HeLa Cell Lines Survived after Acute X-Ray Irradiation at a Dose of 15 Gy.","authors":"A A Tsishnatti, S M Rodneva, Yu A Fedotov, V D Gurev, V N Belyaev, D V Guryev","doi":"10.1007/s10517-025-06413-y","DOIUrl":"10.1007/s10517-025-06413-y","url":null,"abstract":"<p><p>We obtained A549 and HeLa cell lines that survived and showed stable growth after acute X-ray irradiation at a dose of 15 Gy (hereinafter referred to as A549RR and HeLaRR). Comparative studies of the proliferative activity of original (A549, HeLa) and survived (A549RR, HeLaRR) cells and their sensitivity to additional X-ray irradiation at doses of 2, 4, and 6 Gy by the clonogenic capacity and migration potential (scratch-wound test) were carried out. It was found that the doubling time of the cell population for the A549RR and HeLaRR lines was significantly lower than for the original non-irradiated cells without additional exposure. A549RR and HeLaRR cell lines demonstrated higher resistance to additional X-ray irradiation in terms of clonogenic ability. Migration potential, as one of the critical processes during tumor metastasis, appeared to be significantly higher for A549RR cells up to 24 h after irradiation at a dose of 2 Gy and up to 48 h after irradiation at a dose of 4 Gy. Migration of HeLaRR cells was significantly higher without additional exposure and after irradiation at doses of 2 and 4 Gy, while after irradiation at a dose of 6 Gy, migration activity of HeLaRR cells was significantly suppressed compared to original cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"764-768"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental Model of Partially Recovered Blood Loss in Awake Rats. 清醒大鼠部分恢复失血的实验模型。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06416-9
A M Ismailova, M S Severyukhina, V A Palikov, N A Borozdina, S G Semushina, A V Cholina, O N Khokhlova, D I Rzhevsky, G A Slascheva, I A Dyachenko, A N Murashev
{"title":"Experimental Model of Partially Recovered Blood Loss in Awake Rats.","authors":"A M Ismailova, M S Severyukhina, V A Palikov, N A Borozdina, S G Semushina, A V Cholina, O N Khokhlova, D I Rzhevsky, G A Slascheva, I A Dyachenko, A N Murashev","doi":"10.1007/s10517-025-06416-9","DOIUrl":"10.1007/s10517-025-06416-9","url":null,"abstract":"<p><p>We propose a new model of blood loss in awake rats with volume loss up to 40% of total blood volume in the phase of hemorrhagic shock and partial blood replacement up to final blood loss up to 30% of total blood volume. During blood withdrawal, the rats showed manifestation of baroreflex, increased blood levels of glucose and lactate, and decreased concentration of oxyhemoglobin. Partial blood volume compensation was followed by recovery of hemodynamics the levels of glucose and oxyhemoglobin. Thus, taking into account the awake status of rats and compensatory mechanisms, our model of blood loss with a fixed volume of blood drawing and its partial compensation is a relevant model for studying the efficacy of blood substitutes.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"778-781"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor Proteolytic Activity in Esophageal Cancer. 食管癌的肿瘤蛋白水解活性。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06415-w
E I Goufman, N B Tikhonova, K B Gershkovich, A P Aleksankin, A A Stepanov, N V Nizyaeva, V V Bochkov, L M Mikhaleva, O V Kovaleva, I S Stilidi, N E Kushlinskii
{"title":"Tumor Proteolytic Activity in Esophageal Cancer.","authors":"E I Goufman, N B Tikhonova, K B Gershkovich, A P Aleksankin, A A Stepanov, N V Nizyaeva, V V Bochkov, L M Mikhaleva, O V Kovaleva, I S Stilidi, N E Kushlinskii","doi":"10.1007/s10517-025-06415-w","DOIUrl":"10.1007/s10517-025-06415-w","url":null,"abstract":"<p><p>The growth of malignant tumors is accompanied by an increase in plasmin activity, one of the key enzymes in oncogenesis. IgG proteolysis by plasmin yields fragments with exposed C-terminal lysine residues that can bind to plasmin heavy chain. Highly purified plasminogen (plasmin precursor) and heavy chains containing lysine-binding sites were isolated. The formation of IgG fragments as a result of their proteolysis by plasmin in solution was shown. Using ELISA with immobilized heavy chains, we found increased concentration of IgG fragments in the sera of patients with esophageal cancer in comparison with healthy donors. The test had high sensitivity (91%) and specificity (85%).</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"774-777"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling of Frequency Dependence of Selectivity and Sensitivity of Mammalian Otolith Membranes during Electrical Stimulation of the Vestibular Nerves. 前庭神经电刺激时哺乳动物耳石膜选择性和敏感性频率依赖性的建模。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06400-3
V V Udut, V P Demkin, S V Melnichuk, T V Rudenko, M V Svetlik, M D Akinina, O V Demkin, L V Smaglii, V M Alifirova, O V Grebenuk
{"title":"Modeling of Frequency Dependence of Selectivity and Sensitivity of Mammalian Otolith Membranes during Electrical Stimulation of the Vestibular Nerves.","authors":"V V Udut, V P Demkin, S V Melnichuk, T V Rudenko, M V Svetlik, M D Akinina, O V Demkin, L V Smaglii, V M Alifirova, O V Grebenuk","doi":"10.1007/s10517-025-06400-3","DOIUrl":"10.1007/s10517-025-06400-3","url":null,"abstract":"<p><p>A numerical experiment was conducted to determine the spectral sensitivity and selectivity of the cellular components of the utricle and saccule of a laboratory animal (rat) to a periodic electrical stimulation. Equivalent electrical circuit of otolith replacement was used. Its parameters were determined from the anatomical structure and from the measured specific characteristics of cellular elements taking into account the changing ionic conductivity. It was found that the frequency dependence of the impedance and the spectral sensitivity of the cell elements for the utricle and saccule have a resonant nature. The obtained data about the mechanisms of electrical stimulation of hair cells, their spectral sensitivity, and frequency selectivity can serve as the basis for choosing the optimal mode of electrical stimulation in a vestibular implant.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"697-701"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats. 胸腺原类似物对联氨性肝病大鼠的保肝作用。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-29 DOI: 10.1007/s10517-025-06405-y
A A Chulanova, A M Smakhtina, G S Mal, I I Bobyntsev, M Yu Smakhtin, E S Mishina, P M Kopeykin, E G Bogomolova
{"title":"Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.","authors":"A A Chulanova, A M Smakhtina, G S Mal, I I Bobyntsev, M Yu Smakhtin, E S Mishina, P M Kopeykin, E G Bogomolova","doi":"10.1007/s10517-025-06405-y","DOIUrl":"10.1007/s10517-025-06405-y","url":null,"abstract":"<p><p>We studied the reparative and antioxidant effects of thymogen (10 and 100 μg/kg) and its modifications in equimolar doses (12 and 120 μg/kg) obtained by attaching the amino acid D-alanine (D-Ala) to the N- or C-terminus of the peptide molecule. A single intraperitoneal injection of hydrazine hydrochloride caused a decrease in catalase activity and an increase in molondialdehyde (MDA) concentration. Administration of peptides in lower doses inhibited LPO and stimulated reparative regeneration of hepatocytes. Thymogen analogue with D-Ala at the C-terminus was most effective. Increasing the doses of thymogen (100 μg/kg) and its analogues (120 μg/kg) did not lead to further increase in their hepatoprotective activity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"722-725"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differences in the Blood Levels of HIF-1α and VNN1 and Expression of HIF1A and NFKB1 in Leukocytes in Cardiological Patients with Risk of Postoperative Complications. 有术后并发症风险的心脏病患者血液中HIF-1α和VNN1水平及白细胞中HIF1A和NFKB1表达的差异
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06399-7
M V Silina, D Sh Dzhalilova, M A Diatroptova, O O Grin, M A Babaev, O V Makarova
{"title":"Differences in the Blood Levels of HIF-1α and VNN1 and Expression of HIF1A and NFKB1 in Leukocytes in Cardiological Patients with Risk of Postoperative Complications.","authors":"M V Silina, D Sh Dzhalilova, M A Diatroptova, O O Grin, M A Babaev, O V Makarova","doi":"10.1007/s10517-025-06399-7","DOIUrl":"10.1007/s10517-025-06399-7","url":null,"abstract":"<p><p>The systemic inflammatory response that develops after cardiac surgery with the use of cardiopulmonary bypass, has individual features of its course, and perioperative assessment of its activity can serve as a basis for the development of a personalized approach to predicting the development and severity of the course of postoperative complications. We found that patients with high risk of postoperative infectious and inflammatory complications are characterized by high blood levels of HIF-1α and VNN1 proteins before surgery, as well as 24 and 72 h after it, and high level of HIF1A expression in leukocytes 72 h after surgery. The obtained data are necessary for understanding the individual features of the course of the systemic inflammatory response that develops after surgical interventions, as well as for timely treatment of organ dysfunctions during intensive care.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"691-696"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Metabolites of Vaginal Lactobacilli on Neutrophils Function. 阴道乳酸杆菌代谢物对中性粒细胞功能的影响。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-31 DOI: 10.1007/s10517-025-06410-1
Yu L Myachina, A V Sgibnev, Yu I Cherkasova
{"title":"Effect of Metabolites of Vaginal Lactobacilli on Neutrophils Function.","authors":"Yu L Myachina, A V Sgibnev, Yu I Cherkasova","doi":"10.1007/s10517-025-06410-1","DOIUrl":"10.1007/s10517-025-06410-1","url":null,"abstract":"<p><p>We studied the effect of metabolites produced by lactobacilli on the metabolic and killing activities of neutrophil. Treatment with lactic acid at a concentration of 5.6 mM increased dehydrogenase activity and killing activity of neutrophils and slightly decreased the mitochondrial potential in cells; at concentrations of 11.1 and 22.2 mM, lactate decreased dehydrogenase activity, which was accompanied by a decrease in the mitochondrial potential in cells; at a concentration of 11.1 mM, lactate decreased killing activity of neutrophils. Hydrogen peroxide increased the dehydrogenase and killing activities at concentrations of 0.59 and 2.36 mM and decreased these parameters at a concentration of 1.18 mM; these changes were accompanied by a decrease in the number of cells with high mitochondrial potential. It is assumed that the ability of vaginal lactobacilli to modulate neutrophil activity has important evolutionary significance and allows regulating the number of opportunistic microorganisms.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"750-754"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Homoarginine and β-Aminoisobutyric Acid on Migration and Proliferation of Smooth Muscle Cells of Rat Aorta. 精氨酸和β-氨基异丁酸对大鼠主动脉平滑肌细胞迁移和增殖的影响。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-30 DOI: 10.1007/s10517-025-06401-2
D A Tanyanskiy, A Yu Kotov, A V Demyanov, A B Malashicheva, P M Docshin, I V Kudriavtsev
{"title":"The Influence of Homoarginine and β-Aminoisobutyric Acid on Migration and Proliferation of Smooth Muscle Cells of Rat Aorta.","authors":"D A Tanyanskiy, A Yu Kotov, A V Demyanov, A B Malashicheva, P M Docshin, I V Kudriavtsev","doi":"10.1007/s10517-025-06401-2","DOIUrl":"10.1007/s10517-025-06401-2","url":null,"abstract":"<p><p>Non-protein amino acids homoarginine (hArg) and β-aminoisobutyric acid (BAIBA) inhibit atherogenesis by weakening the inflammatory response in the vascular wall. The influence of these amino acids on growth factor-induced migration and proliferation of smooth muscle cells (SMC) of rat aorta was studied in vitro. It was found that hArg and BAIBA did not affect these processes, though the latter were suppressed by NO. Thus, hArg and BAIBA do not directly affect the migration and proliferation of aortic SMC, but can affect these processes indirectly through hArg modulation of NO production by endothelial cells, and, probably, due to the anti-inflammatory properties of these amino acids.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"702-706"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Gene Transcription in Cumulus Cells from Women of Advanced Maternal Age under the Influence of Extracellular Vesicles from Follicular Fluid of Young Donors. 在年轻献血者卵泡液细胞外泡的影响下，高龄产妇积云细胞基因转录的变化
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-04-01 Epub Date: 2025-05-31 DOI: 10.1007/s10517-025-06417-8
B V Zingerenko, O V Burmenskaya, A P Sysoeva, J A Shevtsova, D N Silachev, N P Makarova, E A Kalinina
{"title":"Changes in Gene Transcription in Cumulus Cells from Women of Advanced Maternal Age under the Influence of Extracellular Vesicles from Follicular Fluid of Young Donors.","authors":"B V Zingerenko, O V Burmenskaya, A P Sysoeva, J A Shevtsova, D N Silachev, N P Makarova, E A Kalinina","doi":"10.1007/s10517-025-06417-8","DOIUrl":"10.1007/s10517-025-06417-8","url":null,"abstract":"<p><p>An attempt was made to rejuvenate cumulus cells (CCs) of women of advanced maternal age (AMA) using extracellular vesicles (EV) isolated from the follicular fluid (FF) of young donors. FF samples were taken from healthy women aged 23-26 during the ART program. CCs from patients of advanced maternal age (36-47 years) were co-cultured with EV of young donors. The target genes were selected based on their functions in CC and early embryogenesis (PFKP, EREG, UBE2T, HAS2, VCAN, CYP19A, GREM1, STS, BAX, PTGS2, BCL2, SPSB2, AREG, CCNB1, EGFR). Comparative analysis of all women without stratification by the type of final follicle maturation drug (hCG or gonadotropin-releasing hormone agonist, GnRHa) revealed no statistically significant difference in the expression of the selected genes. In the group treated with GnRHa, a statistically significant increase in the expression of HAS2 (by 1.8 times, p = 0.04), GREM1 (by 1.4 times, p = 0.08), and BAX (by 1.4 times, p = 0.04) in CCs was observed after their co-culturing with FF EVs from young donors. The findings suggest the potential for the \"rejuvenation\" of CC in women of advanced maternal age when aGnRH is used in combination with FF EVs from young women, because the expression of apoptosis genes decreases and the expression cell proliferation gene increases during co-culturing of CC with FF EVs.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"782-787"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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