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Histological and Immunohistochemical Analysis of the Mouse Brain Following Traumatic Brain Injury: Identification of Therapeutic Targets and Establishment of Treatment Windows. 创伤性脑损伤后小鼠脑的组织学和免疫组织化学分析：治疗靶点的确定和治疗窗口的建立。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-09 DOI: 10.1007/s10517-026-06575-3
N N Ermakova, E S Pan, M A Zhukova, V Yu Pan, I L Zharkikh, V E Skurikhina, A M Dygai
{"title":"Histological and Immunohistochemical Analysis of the Mouse Brain Following Traumatic Brain Injury: Identification of Therapeutic Targets and Establishment of Treatment Windows.","authors":"N N Ermakova, E S Pan, M A Zhukova, V Yu Pan, I L Zharkikh, V E Skurikhina, A M Dygai","doi":"10.1007/s10517-026-06575-3","DOIUrl":"10.1007/s10517-026-06575-3","url":null,"abstract":"<p><p>A histological and immunohistochemical analysis (IHC) of the motor cortex and subventricular zone (a neurogenic region) in the right cerebral hemisphere of ICR mice was performed following traumatic brain injury (TBI) induced at the bregma level. Hematoxylin-eosin and cresyl violet staining revealed that TBI causes significant damage to the motor cortex, including tissue edema, neuroinflammation, vascular congestion, cellular and tissue degeneration, disruption of the vascular network, astrolysis, and glial scar formation. Concurrently, the number of neurons in the motor cortex was reduced, while the number of glial cells increased. IHC analysis showed a decreased population of DCX<sup>+</sup> proliferating neuroblasts in the subventricular zone, migration of NeuN<sup>+</sup> neurons from this neurogenic niche toward the injured motor cortex, and impaired migration of GFAP<sup>+</sup> astrocytes. To mitigate neuroinflammation, it is proposed to suppress bone marrow hematopoietic activity and prevent the mobilization of inflammatory cells from the bone marrow into the systemic circulation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"29-34"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypergravity Upregulates and Simulated Microgravity Downregulates TRPM7 Mechanosensitive Ion Channel Expression in Isolated Rat Cardiomyocytes. 超重力上调和模拟微重力下调离体大鼠心肌细胞TRPM7机械敏感离子通道表达
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-09 DOI: 10.1007/s10517-026-06572-6
A D Zolotareva, V I Zolotarev, O V Kamkina, S A Shileiko, V M Mitrokhin, A S Bilichenko, V E Kazansky, A S Rodina, M I Mladenov, A G Kamkin
{"title":"Hypergravity Upregulates and Simulated Microgravity Downregulates TRPM7 Mechanosensitive Ion Channel Expression in Isolated Rat Cardiomyocytes.","authors":"A D Zolotareva, V I Zolotarev, O V Kamkina, S A Shileiko, V M Mitrokhin, A S Bilichenko, V E Kazansky, A S Rodina, M I Mladenov, A G Kamkin","doi":"10.1007/s10517-026-06572-6","DOIUrl":"10.1007/s10517-026-06572-6","url":null,"abstract":"<p><p>Hypergravity (HG) and microgravity (MG) modulate Ca<sup>2+</sup> entry into the cytosol of cardiomyocytes via both voltage-gated and mechanically gated Ca<sup>2+</sup> channels. The last include members of the TRP channel family with TRPM7 being the predominant subtype. We investigated the relationship between changes in TRPM7 channel protein synthesis and the abundance of its corresponding mRNA in cardiomyocytes from rats exposed to HG or MG for 14 days. Using transcriptome sequencing with normalization of \"raw reads\" by the TPM (Transcripts Per Kilobase Million) method, we found that TRPM7 TPM values significantly increased after HG exposure and significantly decreased after MG. Western blotting of TRPM7 protein levels confirmed a pronounced upregulation under HG and a substantial downregulation under MG. These changes may lead to altered ion conductance through mechanically gated channels in cardiomyocytes.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"16-18"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiviral Activity of Plant-Based Preparations against SARS-CoV-2 and Herpes Simplex Virus Type 2 In Vitro: A Review of Experimental Findings. 植物基制剂对SARS-CoV-2和单纯疱疹病毒2型的体外抗病毒活性：实验结果综述
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-09 DOI: 10.1007/s10517-026-06570-8
E I Kazachinskaia, L N Zibareva, Y V Kononova, A M Shestopalov, M I Voevoda, A A Chepurnov
{"title":"Antiviral Activity of Plant-Based Preparations against SARS-CoV-2 and Herpes Simplex Virus Type 2 In Vitro: A Review of Experimental Findings.","authors":"E I Kazachinskaia, L N Zibareva, Y V Kononova, A M Shestopalov, M I Voevoda, A A Chepurnov","doi":"10.1007/s10517-026-06570-8","DOIUrl":"10.1007/s10517-026-06570-8","url":null,"abstract":"<p><p>We reviewed published data on the efficacy of plant-derived preparations, including the authors' original in vitro findings on the antiviral activity of aqueous and dry ethanol extracts against the RNA virus SARS-CoV-2 and the DNA virus herpes simplex virus type 2 (HSV-2). The study evaluates the activity of an aqueous extract prepared from fermented leaves of Epilobium angustifolium L., as well as dry ethanol extracts obtained from clove spice (Syzygium aromaticum L.), black and green tea (Camellia sinensis L.), leaves of Rhaponticum carthamoides, the basidiomycete fungus chaga (Inonotus obliquus (Ach. ex Pers.) Pil.), and four lichen species: Cetraria islandica L., Usnea L., Pseudevernia furfuracea L., and Cladonia stellaris Opiz. HPLC analysis of several dry ethanol extracts suggests that their antiviral activity may be attributed to polyphenolic compounds and ecdysteroids. These findings may serve as a basis both for the identification of individual bioactive plant-derived compounds and for the development of cost-effective therapeutic or prophylactic agents against COVID-19 and for reducing the recurrence rate of chronic genital herpes.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anastasis: Reality or Fiction? Anastasis：现实还是虚构？
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-09 DOI: 10.1007/s10517-026-06591-3
Y S Kim, K V Kovalskaya, S L Malov, G V Manukyan, R V Kholodenko, K N Yarygin, I V Kholodenko
{"title":"Anastasis: Reality or Fiction?","authors":"Y S Kim, K V Kovalskaya, S L Malov, G V Manukyan, R V Kholodenko, K N Yarygin, I V Kholodenko","doi":"10.1007/s10517-026-06591-3","DOIUrl":"10.1007/s10517-026-06591-3","url":null,"abstract":"<p><p>Increased resistance to the apoptosis-inducing stimuli, as well as the reversibility of the process of cell death, are currently recognized as the mechanisms that tumor cells use for survival, maintenance of malignancy, and metastasis. The term \"anastasis\" was introduced to describe the reversibility of cell death. We have previously shown that mesenchymal stem cells (MSCs) are resistant to receptor-mediated apoptosis. In this work, the possibility of anastasis in three types of mesenchymal cells (human liver and placental MSCs and skin fibroblasts) was studied after exposure to common cell death inducers ethanol, staurosporine, or doxorubicin. We have shown that restoration of cell morphology and proliferation occurs after treatment with non-lethal doses of ethanol and low concentration of doxorubicin, while staurosporine at non-lethal concentrations produces an irreversible cytostatic effect.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"119-125"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of the Serotonin Reuptake Inhibitor Fluoxetine on Pain Response in the Formalin Test, Stress System Reactivity, and Spatial Memory in Adult Rats. 血清素再摄取抑制剂氟西汀对成年大鼠福尔马林疼痛反应、应激系统反应和空间记忆的影响
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-09 DOI: 10.1007/s10517-026-06579-z
A D Kalinina, V A Mikhailenko, E A Vershinina, T N Shimaraeva, I P Butkevich
{"title":"Effect of the Serotonin Reuptake Inhibitor Fluoxetine on Pain Response in the Formalin Test, Stress System Reactivity, and Spatial Memory in Adult Rats.","authors":"A D Kalinina, V A Mikhailenko, E A Vershinina, T N Shimaraeva, I P Butkevich","doi":"10.1007/s10517-026-06579-z","DOIUrl":"10.1007/s10517-026-06579-z","url":null,"abstract":"<p><p>The effect of chronic fluoxetine administration (versus saline control) on the behavioral biphasic pain response in the formalin test, hypothalamic-pituitary-adrenal (HPA) axis reactivity, spatial learning, and spatial memory was investigated in adult male rats. Following assessment of the pain response during both the first (acute) and second (tonic) phases of the formalin test, blood samples were collected from half of the experimental and control animals for measurement of plasma corticosterone levels. In the remaining rats, spatial learning and memory were evaluated in the Morris water maze. Chronic fluoxetine treatment produced a significant antinociceptive effect during the second inflammatory phase of the formalin test, which was accompanied by reduced HPA axis reactivity as evidenced by attenuated corticosterone responses. However, fluoxetine administration did not significantly affect performance in the cognitive domain.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"53-58"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphological Alterations of Dopaminergic Neurons in the Substantia Nigra of Spontaneously Hypertensive Rats. 自发性高血压大鼠黑质多巴胺能神经元的形态学改变。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-10 DOI: 10.1007/s10517-026-06589-x
P V Kulikova, V V Guselnikova, D E Korzhevskii
{"title":"Morphological Alterations of Dopaminergic Neurons in the Substantia Nigra of Spontaneously Hypertensive Rats.","authors":"P V Kulikova, V V Guselnikova, D E Korzhevskii","doi":"10.1007/s10517-026-06589-x","DOIUrl":"10.1007/s10517-026-06589-x","url":null,"abstract":"<p><p>Morphological alterations of dopaminergic neurons in the substantia nigra were examined in spontaneously hypertensive rats (SHR) and normotensive Wistar rats. Dopaminergic neurons were identified by immunohistochemical staining for tyrosine hydroxylase. The study revealed a detrimental effect of arterial hypertension on the integrity of dopaminergic neurons in the substantia nigra. The number of neurons exhibiting signs of degeneration in the substantia nigra of SHR was significantly higher than that in control Wistar rats. These findings suggest a potential role of arterial hypertension in the pathogenesis of neurodegeneration in the substantia nigra.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"108-111"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Classical Matrigel Angiogenesis Model Revisited: Key Regulators and Comparative Analysis with 2D/3D Co-Culture Systems. 经典基质血管生成模型重访：关键调节因子和与2D/3D共培养系统的比较分析。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-09 DOI: 10.1007/s10517-026-06596-y
I B Beloglazova, E S Zubkova, K V Dergilev, V V Stepanova, Yu D Goltseva, D N Penkov, Ye V Parfyonova
{"title":"The Classical Matrigel Angiogenesis Model Revisited: Key Regulators and Comparative Analysis with 2D/3D Co-Culture Systems.","authors":"I B Beloglazova, E S Zubkova, K V Dergilev, V V Stepanova, Yu D Goltseva, D N Penkov, Ye V Parfyonova","doi":"10.1007/s10517-026-06596-y","DOIUrl":"10.1007/s10517-026-06596-y","url":null,"abstract":"<p><p>Capillary-like network (CLN) formation on Matrigel is a classical model for assessing the angiogenic properties of cells, though the underlying mechanisms vary across cell types. We identified two distinct CLN formation patterns and evaluated how each type characterizes the angiogenic potential of cells. Only endothelial cells (ECs) capable of elongating during CLN assembly on Matrigel exhibited angiogenic activity in other in vitro models (2D and 3D). Transcriptional profiling of ECs in a 2D co-culture with MSCs showed that CLN formation coincided with the upregulation of genes encoding tight junction proteins, Notch pathway components, and syndecan-2. Stromal cells are also capable of forming CLNs on Matrigel and in 3D model, underscoring their physiological role in tissue remodeling and homeostasis through network assembly.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"155-163"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Immunotoxicity of Fullerenol C60(OH)22-24 on Human Peripheral Blood T and B Lymphocytes. 富勒烯醇C60(OH)22-24对人外周血T、B淋巴细胞免疫毒性的评价。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-09 DOI: 10.1007/s10517-026-06597-x
M S Bochkova, V P Timganova, D I Usanina, S A Zamorina, M B Rayev
{"title":"Evaluation of Immunotoxicity of Fullerenol C<sub>60</sub>(OH)<sub>22-24</sub> on Human Peripheral Blood T and B Lymphocytes.","authors":"M S Bochkova, V P Timganova, D I Usanina, S A Zamorina, M B Rayev","doi":"10.1007/s10517-026-06597-x","DOIUrl":"10.1007/s10517-026-06597-x","url":null,"abstract":"<p><p>Polyhydroxylated fullerenes (fullerenols) C<sub>60</sub>(OH)<sub>n</sub> are allotropes of carbon with promising biomedical applications due to their hydrophilicity, chemical stability, and low toxicity profile. We studied the biocompatibility of fullerenol C<sub>60</sub>(OH)<sub>22-24</sub> with human peripheral blood T and B lymphocytes and adhesion/internalization fullerenol by these cells. A mild cytotoxic effect on T cells was found only at high (100 and 200 μg/ml) concentrations of fullerenol (cell viability decreased by 1-2.5%), whereas B cells were resistant to its cytotoxic effects. Interestingly, the absolute number of viable T cells increased after 72-h incubation with high fullerenol concentrations (50, 100, and 200 μg/ml). We also observed active time- and concentration-dependent adhesion/internalization of fullerenol nanoparticles by lymphocytes, especially B cells. Thus, preliminary evaluation of the immunotoxic potential of fullerenol C<sub>60</sub>(OH)<sub>22-24</sub> toward T and B lymphocytes derived from human peripheral blood was performed.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"164-169"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Search for Molecular Markers of Myocardial Injury in a Mouse Model of Obstructive Nephropathy Using Nestin Promoter-Driven GFP Expression. 利用巢蛋白启动子驱动GFP表达在梗阻性肾病小鼠模型中寻找心肌损伤的分子标记。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-09 DOI: 10.1007/s10517-026-06578-0
I A Sokolov, L D Zorova, D B Zorov, E Y Plotnikov, P A Abramicheva
{"title":"Search for Molecular Markers of Myocardial Injury in a Mouse Model of Obstructive Nephropathy Using Nestin Promoter-Driven GFP Expression.","authors":"I A Sokolov, L D Zorova, D B Zorov, E Y Plotnikov, P A Abramicheva","doi":"10.1007/s10517-026-06578-0","DOIUrl":"10.1007/s10517-026-06578-0","url":null,"abstract":"<p><p>The expression of cardiac dysfunction markers and the number of nestin-positive cells in the myocardium were analyzed in a mouse model of obstructive nephropathy using animals expressing GFP under the nestin promoter. Unilateral ureteral obstruction (UUO) led to an increase in the number of nestin-positive cells in cardiac tissue, accompanied by elevated expression of B-type natriuretic peptide, which positively correlated with GFP levels. A trend toward reduced expression of β-myosin heavy chain and the gap junction protein connexin-43 was observed, whereas the expression of the progenitor cell marker WT1 remained unchanged under UUO conditions. These findings indicate the development of cardiac dysfunction in this model is secondary to primary renal injury and highlight a concomitant expansion of nestin-positive cells within the myocardium.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"48-52"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic Effect of Cu2+ on Cultured Endotheliocytes of the Rat Cerebral Cortex. Cu2+对培养大鼠大脑皮层内皮细胞的细胞毒性作用。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-11-01 Epub Date: 2026-02-09 DOI: 10.1007/s10517-026-06592-2
E V Stelmashook, O P Alexandrova, E E Genrikhs, A E Lapieva, M R Kapkaeva, E A Smirnova, N K Isaev
{"title":"Cytotoxic Effect of Cu<sup>2+</sup> on Cultured Endotheliocytes of the Rat Cerebral Cortex.","authors":"E V Stelmashook, O P Alexandrova, E E Genrikhs, A E Lapieva, M R Kapkaeva, E A Smirnova, N K Isaev","doi":"10.1007/s10517-026-06592-2","DOIUrl":"10.1007/s10517-026-06592-2","url":null,"abstract":"<p><p>We studied the effect of Cu<sup>2+</sup> on cultured endotheliocytes of the rat cerebral cortex. Phase-contrast microscopy of living cultures showed that cell damage in the monolayer and a decrease in the mitochondrial membrane potential (detected with JC-1 dye) occurred when the Cu<sup>2+</sup> concentration in the culture medium reached 0.2 mM and higher. In surviving cells exposed to 0.2 mM Cu<sup>2+</sup>, an increase in the level of p53 protein in the nuclei was revealed. However, statistically significant decrease in the conversion of tetrazolium bromide into formazan was observed starting from 0.1 mM Cu<sup>2+</sup> in the culture medium, and impairment of the barrier function of these cells began from 0.05 mM Cu<sup>2+</sup>.Thus, among the studied parameters, the barrier function of endotheliocytes was proved to be the most sensitive to the toxic effect of copper.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"126-131"},"PeriodicalIF":0.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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