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Bulletin of Experimental Biology and Medicine最新文献

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Level of Cytokines and C3 Complement in the Blood of Rats under Conditions of Chronic Unpredictable Stress of Different Durations. 不同持续时间的慢性不可预测应激条件下大鼠血液中的细胞因子和 C3 补体水平
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06177-x
D V Skripkina, A Yu Abramova, B B Shoibonov, I V Alekseeva, E V Nikenina, S S Pertsov
{"title":"Level of Cytokines and C3 Complement in the Blood of Rats under Conditions of Chronic Unpredictable Stress of Different Durations.","authors":"D V Skripkina, A Yu Abramova, B B Shoibonov, I V Alekseeva, E V Nikenina, S S Pertsov","doi":"10.1007/s10517-024-06177-x","DOIUrl":"10.1007/s10517-024-06177-x","url":null,"abstract":"<p><p>The parameters of the cytokine profile and functional activity of the complement system in the blood of rats were studied during different time periods of chronic unpredictable mild stress using a model of sequentially alternating low-intensity stress effects for 1, 2, 3, and 4 weeks. In the dynamics of observation, a general tendency towards multidirectional fluctuations in the concentration of cytokines was revealed: an increase in IL-10, but a decrease in IL-4 in comparison with the control. Statistically significant changes in the level of IL-10 were noted after 2, 3, and 4 weeks, IL-4 - after 2 and 4 weeks of stress loads. The percentage of lysis of the C3 component in rats gradually increased by the 2nd week of chronic stress, but then decreased and practically did not differ from the control values (intact animals) by the end of the study. These results illustrate the specificity of changes in the indicators of the C component of the complement system and the cytokine profile of the blood reflecting activity of the cellular and humoral components of the immune response in rats exposed to repeated stress factors of different origins and duration.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body Surface Potential Mapping during Atrial Depolarization in Rats with Post-Infarction Chronic Heart Failure against the Background of Fabomotizole Therapy. 心梗后慢性心力衰竭大鼠在法博咪唑治疗背景下心房去极化时的体表电位图。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06185-x
S L Smirnova, I M Roshchevskaya, A G Ivonin, V V Barchukov, I B Tsorin, S A Kryzhanovskii
{"title":"Body Surface Potential Mapping during Atrial Depolarization in Rats with Post-Infarction Chronic Heart Failure against the Background of Fabomotizole Therapy.","authors":"S L Smirnova, I M Roshchevskaya, A G Ivonin, V V Barchukov, I B Tsorin, S A Kryzhanovskii","doi":"10.1007/s10517-024-06185-x","DOIUrl":"10.1007/s10517-024-06185-x","url":null,"abstract":"<p><p>Cardiac remodeling in rats with post-infarction chronic heart failure caused by anterior transmural myocardial infarction leads to an atypical location of areas of positive and negative cardioelectric potentials on the body surface before the onset of the P<sub>II</sub>-wave on the ECG in the limb leads, which is a sign of increased heterogeneity of atrial depolarization associated with the appearance of additional excitation focus in the left atrium. A course of therapy with fabomotizole leads to a decrease in the heterogeneity of atrial depolarization at the initial stages of the formation of the cardioelectric field of the atria on the body surface before the onset of the P<sub>II</sub>-wave, thereby producing an antiarrhythmic effect.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Features of Tongue Cancer Recurrence in Young Adults. 年轻人舌癌复发的遗传特征
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-11 DOI: 10.1007/s10517-024-06189-7
E S Kolegova, A A Schegoleva, R S Vorobev, I K Fedorova, D E Kulbakin, A P Polyakov, A V Mordovsky, L P Yakovleva, A S Vyalov, V T Tsiklauri, M A Kropotov, N G Suchkova, N S Sukortseva, I V Reshetov, E L Choinzonov, E V Denisov
{"title":"Genetic Features of Tongue Cancer Recurrence in Young Adults.","authors":"E S Kolegova, A A Schegoleva, R S Vorobev, I K Fedorova, D E Kulbakin, A P Polyakov, A V Mordovsky, L P Yakovleva, A S Vyalov, V T Tsiklauri, M A Kropotov, N G Suchkova, N S Sukortseva, I V Reshetov, E L Choinzonov, E V Denisov","doi":"10.1007/s10517-024-06189-7","DOIUrl":"10.1007/s10517-024-06189-7","url":null,"abstract":"<p><p>To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor. In addition, the primary tumor and recurrence tongue cancer tissue harbored amplification of the 20p13 region containing C20orf96, DEFB125, DEFB126, DEFB127, DEFB128, DEFB129, DEFB132, and ZCCHC3 genes. Thus, genetic alterations have been identified that are associated with tongue cancer recurrence in young adults.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Diet-Induced Obesity and Programs for Body Weight Reduction on the Histostructure of the Triceps Surae Muscle in Male Rats. 饮食诱发肥胖和减轻体重计划对雄性大鼠肱三头肌组织结构的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-12 DOI: 10.1007/s10517-024-06194-w
T E Kuznetsova, T A Mityukova, A A Basalai, M A Darenskaya, L V Rychkova, S I Kolesnikov, N V Semenova, L I Kolesnikova
{"title":"Effects of Diet-Induced Obesity and Programs for Body Weight Reduction on the Histostructure of the Triceps Surae Muscle in Male Rats.","authors":"T E Kuznetsova, T A Mityukova, A A Basalai, M A Darenskaya, L V Rychkova, S I Kolesnikov, N V Semenova, L I Kolesnikova","doi":"10.1007/s10517-024-06194-w","DOIUrl":"10.1007/s10517-024-06194-w","url":null,"abstract":"<p><p>We studied the effects of visceral obesity induced by a high-calorie diet and health-improving variants of its correction on morphological characteristics of the muscle tissue in male Wistar rats. At stage I, the rats received standard (StD) or high-calorie diet (HCD) for 8 weeks. At stage II, the animals were divided into the following subgroups: no correction (StD and HCD), switching from HCD to StD (HCD/StD) and/or connection of physical activity in the form of treadmill running (StD+running, HCD+running, and HCD/StD+running) for the next 8 weeks. Diet-induced visceral obesity was shown to result in a decrease in the weight of the triceps surae muscle, fatty infiltration, intracellular edema, partial lysis of contractile elements, weak inflammatory response, and decreased muscle fiber area on cross section. Treadmill running (HCD+running) exacerbates the morphological changes, but returns muscle fiber area to normal. Correction of visceral obesity and relative normalization of muscle tissue structure was noted when switching to a standard diet (HCD/StD and HCD/StD+running).</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhesus Macaques: VNTR Polymorphism of the FCGRT Gene. 猕猴：FCGRT 基因的 VNTR 多态性。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-12 DOI: 10.1007/s10517-024-06193-x
L E Pavlova, M F Timina, A A Agumava, A V Panchenko
{"title":"Rhesus Macaques: VNTR Polymorphism of the FCGRT Gene.","authors":"L E Pavlova, M F Timina, A A Agumava, A V Panchenko","doi":"10.1007/s10517-024-06193-x","DOIUrl":"10.1007/s10517-024-06193-x","url":null,"abstract":"<p><p>Variable number tandem repeat (VNTR) polymorphisms of the human neonatal IgG Fc receptor α-chain gene (FCGRT) are known to influence the expression levels of FCGRT and IgG in serum. Monkeys are considered to be a relevant biological model for studying the effects of immunobiological drugs. The study determined the functional VNTR polymorphisms of the FCGRT gene in 109 male rhesus macaques from the nursery of the Kurchatov Complex of Medical Primatology. PCR amplification of samples was carried out followed by electrophoretic separation of DNA fragments in a 2% agarose gel. Individual DNA amplification products were sequenced (according to Sanger system) in forward and reverse directions to confirm the specificity. The genotyping showed that the VNTR polymorphism of the FCGRT gene in the studied population of rhesus macaques is presented by 9 variants. The frequency of the VNTR5 allele associated with lower IgG levels was 14.2%, and the most common one was the VNTR7 allele (25.2%). We also identified alleles that have not been previously reported: VNTR3, VNTR4, VNTR6, VNTR8, and VNTR9. The study allows to consider rhesus macaques as a potential model for studying the immunological response depending on the genetic VNTR variant of FCGRT.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the Intensity of Nitric Oxide Production in Different Parts of the Spinal Cord after Modeling Combined Cerebral and Spinal Injury. 脑脊髓联合损伤模型后脊髓不同部位一氧化氮生成强度分析
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06176-y
Kh L Gainutdinov, V A Kulchitsky, G G Yafarova, V V Andrianov, L V Bazan, T K Bogodvid, D I Silantyeva, A V Nagibov
{"title":"Analysis of the Intensity of Nitric Oxide Production in Different Parts of the Spinal Cord after Modeling Combined Cerebral and Spinal Injury.","authors":"Kh L Gainutdinov, V A Kulchitsky, G G Yafarova, V V Andrianov, L V Bazan, T K Bogodvid, D I Silantyeva, A V Nagibov","doi":"10.1007/s10517-024-06176-y","DOIUrl":"10.1007/s10517-024-06176-y","url":null,"abstract":"<p><p>Using the method of electron paramagnetic resonance spectroscopy, we showed that NO production decreases by 60% (p<0.05) in the region located rostral to the spinal cord injury 7 days after combined injury to the brain and spinal cord. At the same time, NO production did not change in the site of spinal cord injury and caudal to the injury. The intensity of NO production in similar parts of the spinal cord in intact animals remained unchanged.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical, Pathological, and Immunohistochemical Predictors of Cause-Specific Mortality in Papillary Thyroid Cancer: Multivariate Analysis. 甲状腺乳头状癌病因特异性死亡率的临床、病理和免疫组化预测因素：多变量分析
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-12 DOI: 10.1007/s10517-024-06188-8
M A Bakarev, A A Ivanov, E L Lushnikova
{"title":"Clinical, Pathological, and Immunohistochemical Predictors of Cause-Specific Mortality in Papillary Thyroid Cancer: Multivariate Analysis.","authors":"M A Bakarev, A A Ivanov, E L Lushnikova","doi":"10.1007/s10517-024-06188-8","DOIUrl":"10.1007/s10517-024-06188-8","url":null,"abstract":"<p><p>The association of clinical, pathological, and immunohistochemical characteristics of papillary thyroid cancer with cause-specific mortality was analyzed in a case-control study within a cohort of patients from the Altai Regional Oncology Center. According to multivariate analysis, the independent predictors of fatal outcome within 10 years after surgery in patients living in Altai region are nuclear pattern of Hsp70 expression, thyroid capsular invasion, Ki-67 expression index >7%, and patient's age >45 years for men and >50 years for women. The prognostic model based on these features contributes to a significant improvement in the individual prognostic performance for papillary thyroid cancer in the modeling sample. The model has high statistical significance (χ<sup>2</sup>=64.73; p<0.001) and discriminative power (AUC=0.950, prediction accuracy 88.5%).</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nrf2-Regulated Antioxidant System in Cells of In Vivo Drug-Resistant P388 Murine Leukemia Strains. 体内耐药 P388 株鼠白血病细胞中的 Nrf2 调节的抗氧化系统
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-14 DOI: 10.1007/s10517-024-06181-1
A A Balakina, T A Raevskaya, V I Amozova
{"title":"Nrf2-Regulated Antioxidant System in Cells of In Vivo Drug-Resistant P388 Murine Leukemia Strains.","authors":"A A Balakina, T A Raevskaya, V I Amozova","doi":"10.1007/s10517-024-06181-1","DOIUrl":"10.1007/s10517-024-06181-1","url":null,"abstract":"<p><p>We studied the expression of Nrf2 transcription factor and antioxidant system proteins in drug-resistant murine leukemia strains P388 in vivo, as well as the redox status of cells under conditions of induced oxidative stress. Immunoblotting and real-time PCR showed that the cyclophosphamide-resistant strain P388 (P388/CP) exhibits Nrf2-mediated drug resistance. Cells of the P388/CP strain are characterized by high expression of Nrf2, which leads to a significant increase in the expression of ARE genes and antioxidant system proteins, as well as to the effective maintenance of redox homeostasis under conditions of induced oxidative stress. Taking into account the important role of Nrf2 overexpression in reducing the effectiveness of chemotherapy in patients with different leukemias, the P388/CP strain can be of great interest as a model in the development of new drugs for the treatment of malignant neoplasms.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer Effects of Spiperone in C57BL/6 Mice with Emphysema and Lung Carcinoma. 斯哌酮对肺气肿和肺癌 C57BL/6 小鼠的抗癌作用
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-12 DOI: 10.1007/s10517-024-06191-z
N N Ermakova, M A Zhukova, E S Pan, V Yu Pan, S G Morozov, A A Kubatiev, A M Dygai, E G Skurikhin
{"title":"Anticancer Effects of Spiperone in C57BL/6 Mice with Emphysema and Lung Carcinoma.","authors":"N N Ermakova, M A Zhukova, E S Pan, V Yu Pan, S G Morozov, A A Kubatiev, A M Dygai, E G Skurikhin","doi":"10.1007/s10517-024-06191-z","DOIUrl":"10.1007/s10517-024-06191-z","url":null,"abstract":"<p><p>The antitumor and antimetastatic activity of dopamine D2 receptor antagonists spiperone was studied in C57BL/6 mice in a model of combined pathology (emphysema and lung cancer). Emphysema was induced by administration of LPS and cigarette smoke extract. Lung cancer was induced by injection of Lewis lung carcinoma cells into the lung. It has been shown that under conditions of combined lung pathology, spiperone prevents inflammatory infiltration and emphysematous expansion of the lungs and reduces the size of the primary tumor node, the number of metastases, and the area of the lungs affected by metastases. Spiperone reduces the number of cancer stem cells (CSCs) in the lungs and blood of mice with combined pathology. CSCs isolated from the lungs and blood of mice with combined pathology treated with spiperone had a significantly lower potential to form a tumorosphere in vitro than CSCs from untreated mice with emphysema and lung carcinoma. Thus, blockade of dopamine D2 receptors is a promising approach for correcting combined lung pathology and can be used in the development of a method for treating lung cancer in patients with emphysema.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Hafnia alvei on Morphophysiologic Parameters and Gut Microbiota of Mice with Inherited Type 2 Diabetes Mellitus. Hafnia alvei 对遗传性 2 型糖尿病小鼠的形态生理参数和肠道微生物群的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-10 DOI: 10.1007/s10517-024-06180-2
V A Zolotarev, V O Murovets, N S Novikova, E I Ermolenko, A L Sepp, R P Khropycheva
{"title":"Effect of Hafnia alvei on Morphophysiologic Parameters and Gut Microbiota of Mice with Inherited Type 2 Diabetes Mellitus.","authors":"V A Zolotarev, V O Murovets, N S Novikova, E I Ermolenko, A L Sepp, R P Khropycheva","doi":"10.1007/s10517-024-06180-2","DOIUrl":"10.1007/s10517-024-06180-2","url":null,"abstract":"<p><p>Inbred mouse strains KK.Cg-a/a and KK.Cg-Ay/a known as genetic models of type 2 diabetes mellitus significantly surpassed the control strain C57BL/6J in the body weight, relative weight of extractable fat, and basal blood glucose levels. Real-timePCR of fecal samples from KK.Cg-a/a and KK.Cg-A<sup>y</sup>/a mice revealed dysbiosis typical of type 2 diabetes mellitus in humans and animals. Long-term intragastric administration of a suspension of Hafnia alvei bacteria had no effect on the above morphometric and biochemical parameters. At the same time, recovery of the Bacteroides spp. population in KK.Cg-A<sup>y</sup>/a mice and a decrease in the number of Bifidobacterium spp. in KK.Cg-a/a mice were observed. The possibility of therapeutic use of the probiotic based on H. alvei is discussed.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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