发布求助
文献互助 智能选刊 最新文献

Bulletin of Experimental Biology and Medicine最新文献

筛选
英文 中文
Loss of Myofibrils in Cardiomyocytes as a Morphological Indicator of Reduced Compensatory Capabilities of Hypertrophied Myocardium. 心肌细胞中肌原纤维的缺失是肥厚心肌补偿能力降低的形态学指标。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-23 DOI: 10.1007/s10517-024-06295-6
T V Sukhacheva, R A Serov, L A Bockeria
{"title":"Loss of Myofibrils in Cardiomyocytes as a Morphological Indicator of Reduced Compensatory Capabilities of Hypertrophied Myocardium.","authors":"T V Sukhacheva, R A Serov, L A Bockeria","doi":"10.1007/s10517-024-06295-6","DOIUrl":"10.1007/s10517-024-06295-6","url":null,"abstract":"<p><p>The functioning of the ventricular myocardium in hypertrophic cardiomyopathy (HCM) under high hemodynamic load leads to depletion of its resources and is associated with the risk of developing a dilated stage. In patients with HCM, the cardiomyocytes of the interventricular septum are hypertrophied, the proportion of cardiomyocytes in which myofibrils constitute less than 50% of the sarcoplasm volume increases with increasing the cardiomyocyte length and correlates with echocardiographic signs of left ventricular obstruction. These cardiomyocytes are characterized by ultrastructural signs of synthetic activity. In the myocardium of patients with HCM, single cardiomyocytes with \"critical\" loss of myofibrils and nonspecific degenerative changes corresponding to the picture of irreversible changes in the cardiomyocyte ultrastructure were revealed. The presence of cardiomyocytes with this ultrastructural phenotype is an early marker of exhaustion of the compensatory capabilities of the myocardium in HCM.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"130-138"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polymorphisms of ANPEP Gene Are Associated with Microvascular Complications of Type 2 Diabetes. ANPEP 基因的多态性与 2 型糖尿病的微血管并发症有关。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06286-7
Ya E Korvyakova, I E Azarova, D D Markina, M I Churilin, O Yu Bushueva, E Yu Klyosova, M A Solodilova, A V Polonikov
{"title":"Polymorphisms of ANPEP Gene Are Associated with Microvascular Complications of Type 2 Diabetes.","authors":"Ya E Korvyakova, I E Azarova, D D Markina, M I Churilin, O Yu Bushueva, E Yu Klyosova, M A Solodilova, A V Polonikov","doi":"10.1007/s10517-024-06286-7","DOIUrl":"10.1007/s10517-024-06286-7","url":null,"abstract":"<p><p>We studied the association of polymorphisms in the aminopeptidase N gene (ANPEP) with the development of diabetic retinopathy and nephropathy in patients with type 2 diabetes mellitus (T2DM). DNA samples from T2DM patients (n=1425) were genotyped for 23 single nucleotide polymorphisms (SNPs) using the MassARRAY system. Associations of SNP rs13380049 of the ANPEP gene with a lower risk of diabetic retinopathy (OR=0.54, 95%CI 0.36-0.82, p=0.0032) and nephropathy (OR=0.66, 95%CI 0.44-0.99, p=0.048) were found in T2DM patients. In addition, SNP rs25653 was associated with retinopathy, and polymorphisms rs6496608, rs72756574, rs9920421, and rs4932143 were associated with diabetic nephropathy. The study demonstrated the contribution of ANPEP gene polymorphisms in the determination of microvascular complications in T2DM patients.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"79-85"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Hindlimb Unloading of Rats on Rheographic Parameters of Femoral and Brachial Arteries In Situ. 大鼠后肢卸载对股动脉和肱动脉原位流变学参数的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06276-9
L N Tikhomirova, Yu S Medvedeva, M A Lebedeva, I Yu Gavrilov, S V Revenko, M Yu Karganov, E G Popov, I A Tarakanov
{"title":"The Effects of Hindlimb Unloading of Rats on Rheographic Parameters of Femoral and Brachial Arteries In Situ.","authors":"L N Tikhomirova, Yu S Medvedeva, M A Lebedeva, I Yu Gavrilov, S V Revenko, M Yu Karganov, E G Popov, I A Tarakanov","doi":"10.1007/s10517-024-06276-9","DOIUrl":"10.1007/s10517-024-06276-9","url":null,"abstract":"<p><p>The rheographic parameters of the segments of brachial and femoral arteries were measured in situ after a 14-day-long hindlimb unloading (HU) of rats. HU significantly increased electrical impedance Z of a segment of femoral artery indicating its constriction; in parallel, HU resulted in a decreasing trend of Z of a segment of brachial artery attesting to its dilation. In both arteries, HU significantly or as a trend decreased the swing ranges of active and passive pulsations, respectively. BP reduction during bloodletting induced transition from passive to active pulsatile mode in the femoral artery only in 33% experimental rats in contrast to 87% control ones. We suppose that degradation of active pulsatile mode is responsible for the negative influences of microgravity and weightlessness on blood circulation. The study determined the rheographic parameters that reliably reflect changes in the functional activity of arteries after chronic redistribution of hydrostatic load.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"24-29"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental Study of Products Based on Biocompatible Polymer Material from Methacrylic Oligomers as a Potential Barrier for Preventing Adhesions in Cardiac Surgery. 基于甲基丙烯酸低聚物生物相容性聚合物材料的产品作为防止心脏手术粘连的潜在屏障的实验研究。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-25 DOI: 10.1007/s10517-024-06300-y
O A Egunov, S A Afanasiev, D S Kondratieva, E F Muslimova, I V Stepanov, A S Grishin, E R Mikheeva, A A Boshchenko
{"title":"Experimental Study of Products Based on Biocompatible Polymer Material from Methacrylic Oligomers as a Potential Barrier for Preventing Adhesions in Cardiac Surgery.","authors":"O A Egunov, S A Afanasiev, D S Kondratieva, E F Muslimova, I V Stepanov, A S Grishin, E R Mikheeva, A A Boshchenko","doi":"10.1007/s10517-024-06300-y","DOIUrl":"10.1007/s10517-024-06300-y","url":null,"abstract":"<p><p>The effectiveness and safety of two types of samples based on a biocompatible polymer material made of methacrylic oligomers (Reperen) as a potential antiadhesion pericardial barrier were evaluated in in vitro and in vivo experiments. Two kinds of samples, reinforced with a polyamide mesh and without reinforcement, were used. In in vitro experiments, no adhesion and aggregation of human fibroblasts to the test samples were detected. In in vivo experiments, the samples implanted to rats into the thigh muscles were easily separated from the surrounding tissues 1, 2, and 3 weeks after implantation, being weakly fixed only in the area of the edges. Histological examination at week 2 after implantation revealed no differences between the experimental and control groups. At week 1 and 3, fibrosis and inflammation were more pronounced in animals of the control group (with simulated implantation). The properties demonstrated by both samples of Reperen barriers (with and without polyamide mesh reinforcement) in vivo and in vitro allow considering them as a potential antiadhesion pericardial barrier for clinical use.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"163-168"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of a Short-Term High-Fat Diet on Microbiota Biodiversity of the Small and Large Intestines of C57BL/6SPF Mice. 短期高脂饮食对 C57BL/6SPF 小鼠大小肠微生物群生物多样性的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06275-w
A A Zabolotneva, T A Laskina, D N Kharchev, A V Shestopalov
{"title":"Effects of a Short-Term High-Fat Diet on Microbiota Biodiversity of the Small and Large Intestines of C57BL/6SPF Mice.","authors":"A A Zabolotneva, T A Laskina, D N Kharchev, A V Shestopalov","doi":"10.1007/s10517-024-06275-w","DOIUrl":"10.1007/s10517-024-06275-w","url":null,"abstract":"<p><p>Long-term high-fat diet (HFD) promotes the formation of excess body weight and disorders of lipid metabolism and causes persistent dysbiotic changes in the intestinal microbial community. Changes in eating behavior, endocrine and immune functions of the host are associated with changes in the structure and functional activity of microbial communities. Short-term HFD may also influence the composition and function of the intestinal microbiota, but data on this issue are limited, and most papers are focused on the study of the large intestinal microbiota. The present study examined the effect of short-term HFD (4 weeks) on the structure of microbial communities in the small and large intestines of 24 mice. High-throughput metagenomic sequencing was performed on 48 samples of small and large intestine contents. It was revealed that short-term HFD in mice contributed to impaired glucose tolerance and increased the diversity of microbiota in the colon, but not of the small intestine, and also led to changes in the representation of certain microbial taxa (in particular Tenericutes and Verrucomicrobia). Furthermore, short-term HFD increased blood glucose levels compared to control mice (fed a normal diet), but did not affect lipid metabolism. The results will help to assess the contribution of environmental factors to the structure of microbial communities of the small and large intestines and may also be useful for correcting dysbiotic conditions, including when prescribing therapeutic diets (for example, a ketogenic diet).</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"17-23"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal Properties of Glioma Cell Lines. 胶质瘤细胞系的间充质特性。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-25 DOI: 10.1007/s10517-024-06294-7
I V Kholodenko, A Y Lupatov, Y S Kim, R Y Saryglar, R V Kholodenko, K N Yarygin
{"title":"Mesenchymal Properties of Glioma Cell Lines.","authors":"I V Kholodenko, A Y Lupatov, Y S Kim, R Y Saryglar, R V Kholodenko, K N Yarygin","doi":"10.1007/s10517-024-06294-7","DOIUrl":"10.1007/s10517-024-06294-7","url":null,"abstract":"<p><p>Screening of cell surface markers of three glioma cell lines (astrocytoma 1321N1, glioblastoma T98g, and glioblastoma astrocytoma U373 MG) was performed. Glioma cells expressed common mesenchymal cell markers, although the expression levels varied between the cell lines. The expression of proneural markers and glioma cancer stem cell markers was very low and also varied. Induction of differentiation towards the mesodermal cell lineages showed effective adipogenic and osteogenic differentiation for only the U373 MG cell line, while the 1321N1 and T98g lines demonstrated weak adipogenic potential and failed to undergo osteogenic differentiation. The obtained results point to the intratumor phenotypical heterogeneity of cells in gliomas and to the differences between the three studied types of gliomas with regard to the content of cells with mesenchymal phenotype.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"122-129"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Concentrations of Pro- and Anti-Inflammatory Cytokines in Wistar Rats Subjected to Immobilization Stress and Treated with Tuftsin-Pro-Gly-Pro Peptide. 接受固定应激和 Tuftsin-Pro-Gly-Pro 肽治疗的 Wistar 大鼠血清中促炎症细胞因子和抗炎症细胞因子的浓度。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI: 10.1007/s10517-024-06273-y
M S Krivoshlykova, I I Bobyntsev, A O Vorvul, O A Medvedeva, Iu E Azarova
{"title":"Serum Concentrations of Pro- and Anti-Inflammatory Cytokines in Wistar Rats Subjected to Immobilization Stress and Treated with Tuftsin-Pro-Gly-Pro Peptide.","authors":"M S Krivoshlykova, I I Bobyntsev, A O Vorvul, O A Medvedeva, Iu E Azarova","doi":"10.1007/s10517-024-06273-y","DOIUrl":"10.1007/s10517-024-06273-y","url":null,"abstract":"<p><p>It was found that 28-day immobilization stress in male Wistar rats leads to significant increase in the serum concentrations of proinflammatory cytokines IL-1β, IL-6, IFNγ, and monocyte chemoattractant protein-1 (MCP-1) and a decrease in the content of anti-inflammatory IL-10, as well as the ratio IL-1β/IL-10, IL-6/IL-10, and IFNγ/IL-10 compared to non-stressed animals. Administration of the heptapeptide tuftsin-Pro-Gly-Pro produced a corrective effect on cytokine concentrations under stress conditions: at a dose of 750 μg/kg, the peptide decreased the concentrations of IL-1β, IFNγ, and MCP-1 and cytokine ratios (IL-1β/IL-10 and IFNγ/IL-10), while at a dose of 250 μg/kg, it increased IL-10 levels and decreased IL-6/IL-10 and IFNγ/IL-10 ratios.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"7-10"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of the Genotype of TNFα with the Efficiency of the Intensive Phase of Chemotherapy and Formation of the Sizes of Destruction Cavities in Patients with Pulmonary Tuberculosis. TNFα基因型与肺结核患者强化化疗阶段的效率和破坏腔大小的形成的关系
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06283-w
N P Balobanova, M A Alymenko, R Sh Valiev, N R Valiev, Ya A Safonov, V A Lipatov, A V Polonikov, V A Ragulina, G S Mal, V M Kolomiets
{"title":"Association of the Genotype of TNFα with the Efficiency of the Intensive Phase of Chemotherapy and Formation of the Sizes of Destruction Cavities in Patients with Pulmonary Tuberculosis.","authors":"N P Balobanova, M A Alymenko, R Sh Valiev, N R Valiev, Ya A Safonov, V A Lipatov, A V Polonikov, V A Ragulina, G S Mal, V M Kolomiets","doi":"10.1007/s10517-024-06283-w","DOIUrl":"10.1007/s10517-024-06283-w","url":null,"abstract":"<p><p>The interrelation between the TNFα gene polymorphism and the effectiveness of the intensive phase of chemotherapy in patients with pulmonary tuberculosis, as well as the formation of diameter of the sizes of destruction cavities was studied. It was revealed that the most adverse course of the disease and a high frequency of formation of destruction cavities are associated with the GG genotype of the TNFα gene.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"65-67"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardioprotective Effect of Selective μ2-Opioid Receptor Agonist Endomorphin-1 in Cardiac Reperfusion In Vivo and In Vitro. 选择性μ2-阿片受体激动剂内啡肽-1对体内和体外心脏再灌注的心脏保护作用
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06287-6
A S Gorbunov, A V Mukhomedzyanov, S V Popov, V N Azev, L N Maslov
{"title":"Cardioprotective Effect of Selective μ<sub>2</sub>-Opioid Receptor Agonist Endomorphin-1 in Cardiac Reperfusion In Vivo and In Vitro.","authors":"A S Gorbunov, A V Mukhomedzyanov, S V Popov, V N Azev, L N Maslov","doi":"10.1007/s10517-024-06287-6","DOIUrl":"10.1007/s10517-024-06287-6","url":null,"abstract":"<p><p>The effect of the selective μ<sub>2</sub>-opioid receptor agonist endomorphin-1 in reperfusion injury in male Wistar rats was studied in vivo and in vitro. The in vivo experiment included coronary artery occlusion (45 min) and reperfusion (120 min); in in vitro experiments, 45-min global ischemia of the isolated rat heart was followed by 30-min reperfusion. Endomorphin-1 was administered intravenously 5 min before in vivo reperfusion (at a dose 50 μg/kg) or added to the perfusion solution at the onset of reperfusion of the isolated heart (in a concentration of 152 nmol/liter). In vivo endomorphin-1 reduced the infarct size by 33% compared to the control group. In experiments on isolated heart, endomorphin-1 improved the contractile function during reperfusion and reduced the creatine kinase level in the coronary effluent. Hence, stimulation of cardiac μ<sub>2</sub>-opioid receptors increases heart tolerance to the pathogenic effects of reperfusion.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"86-90"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of Stress-Induced Changes in Heart Rate Variability During Blockade of Central and Stimulation of Peripheral Serotonin and Dopamine Receptors in Rats. 阻断大鼠中枢羟色胺和多巴胺受体及刺激外周羟色胺和多巴胺受体时压力诱发的心率变异性变化的特征
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-11-01 Epub Date: 2024-11-22 DOI: 10.1007/s10517-024-06279-6
E V Kuryanova, V O Stupin, A V Tryasuchev
{"title":"Features of Stress-Induced Changes in Heart Rate Variability During Blockade of Central and Stimulation of Peripheral Serotonin and Dopamine Receptors in Rats.","authors":"E V Kuryanova, V O Stupin, A V Tryasuchev","doi":"10.1007/s10517-024-06279-6","DOIUrl":"10.1007/s10517-024-06279-6","url":null,"abstract":"<p><p>The dynamics of heart rate variability (HRV) during acute stress was studied in male nonlinear rats that received single injection of serotonin (200 μg/kg) or dopamine (60 μg/kg), regular (4-fold) injections of central serotonin receptor blockers (ketanserin and granisetron, 0.1 mg/kg each) or central dopamine receptor blockers (0.1 mg/kg SCH-23390 and 10 mg/kg sulpiride), as well as a combination of central receptor blockers with the administration of serotonin or dopamine, respectively. During stress against the background of serotonin receptors blockade, a weak tachycardia, low stress index, high rhythm variability, especially in the low-frequency range were recorded; against the background of dopamine receptors blockade, increased reactivity to stress at high HR, an initial increase in the stress index, and a decrease in rhythm variability, followed by an increase in the proportion of very low frequency waves in the spectrum were revealed. Serotonin and dopamine, by stimulating peripheral receptors, predominantly weakened stress-induced changes in HRV (especially serotonin), but in combination with blockade of the corresponding central receptors contributed to maintaining tachycardia, reduced rhythm variability, and potentiated the effects of blockers in relation to stress induced changes in the wave structure of the HRV spectrum. We believe that central and peripheral serotoninergic and dopaminergic structures are involved in the formation of HRV by modulating the activity of components of the autonomous and central circuits of HR regulation, respectively.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"40-48"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信