发布求助
文献互助 智能选刊 最新文献

Bulletin of Experimental Biology and Medicine最新文献

筛选
英文 中文
Reaction of the Blood System of ICR Mice with Traumatic Brain Injury. 创伤性脑损伤后ICR小鼠血液系统反应。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06678-x
N N Ermakova, V E Skurikhina, E S Pan, M A Zhukova, I L Zharkikh, V Yu Pan, A M Dygai
{"title":"Reaction of the Blood System of ICR Mice with Traumatic Brain Injury.","authors":"N N Ermakova, V E Skurikhina, E S Pan, M A Zhukova, I L Zharkikh, V Yu Pan, A M Dygai","doi":"10.1007/s10517-026-06678-x","DOIUrl":"10.1007/s10517-026-06678-x","url":null,"abstract":"<p><p>We studied changes in the blood system of ICR mice following traumatic brain injury (TBI). It was found that, along with neuroinflammation, TBI also causes bone marrow hyperplasia and leukocytosis by inducing the formation of additional centers of granulocytic hematopoiesis (hematopoietic islands) and the activation of granulocyte progenitor cells. These results support the hypothesis that neuroinflammation in TBI is dependent on bone marrow hematopoiesis and the mobilization of immune cells and blood cells from the bone marrow to the blood. They also suggest that the bone marrow may be a potential therapeutic target in the treatment of neuroinflammation.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"571-576"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Modified Nucleotides on the Immunogenicity of the H1N1 Influenza mRNA Vaccine. 修饰核苷酸对H1N1流感mRNA疫苗免疫原性的影响
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06688-9
S I Krasnikova, S V Sharabrin, D N Kisakov, M B Borgoyakova, E V Starostina, E V Tigeeva, K P Makarova, V A Yakovlev, K I Ivanova, A P Rudometov, A A Ilyichev, L I Karpenko
{"title":"Effect of Modified Nucleotides on the Immunogenicity of the H1N1 Influenza mRNA Vaccine.","authors":"S I Krasnikova, S V Sharabrin, D N Kisakov, M B Borgoyakova, E V Starostina, E V Tigeeva, K P Makarova, V A Yakovlev, K I Ivanova, A P Rudometov, A A Ilyichev, L I Karpenko","doi":"10.1007/s10517-026-06688-9","DOIUrl":"10.1007/s10517-026-06688-9","url":null,"abstract":"<p><p>We analyzed the effect of modified nucleotides on the immunogenicity of mRNA vaccine encoding hemagglutinin of the influenza A/California/04/09(H1N1) pdm09 virus. Seven mRNA-H1 variants including the following modified bases in different ratios were obtained: N1-methylpseudouridine (m1Ψ), pseudouridine (Ψ), N6-methyladenine (m6A), and 5-methylcytidine (m5C). The efficacy of the resulting mRNA vaccines was assessed by their ability to induce specific antibodies and T-cell response in immunized mice. Virus-neutralizing activity was recorded in groups of animals immunized with mRNAs containing 100% m1Ψ, 100% Ψ, and 100% U. It was shown that mRNAs including 100% m1Ψ or 100% Ψ were more effective than other mRNA variants and induced potent B- and T-cell immune response.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"622-626"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of Changes in Plasma Concentrations of Sex Hormones in Female Rats at Different Stages of Experimental Pain Syndrome in the Maxillofacial Region. 实验性疼痛综合征不同阶段雌性大鼠颌面部性激素血浆浓度变化特征
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06680-3
O S Pak, V D Vinnikova, A V Klimenko, A Yu Abramova, S S Pertsov
{"title":"Features of Changes in Plasma Concentrations of Sex Hormones in Female Rats at Different Stages of Experimental Pain Syndrome in the Maxillofacial Region.","authors":"O S Pak, V D Vinnikova, A V Klimenko, A Yu Abramova, S S Pertsov","doi":"10.1007/s10517-026-06680-3","DOIUrl":"10.1007/s10517-026-06680-3","url":null,"abstract":"<p><p>We studied changes in estradiol and testosterone concentrations in the peripheral blood plasma of female rats at different time points (14 and 28 days) following the induction of maxillofacial pain syndrome via intra-articular injection of sodium monoiodoacetate into the temporomandibular joint. It was found that rats with pain syndrome exhibited higher plasma estradiol levels in comparison with those in both passive control groups (on days 14 and 28) and active control group (on day 28). On day 28, testosterone levels in the experimental animals were lower than in rats that received saline solution. These findings suggest that the most pronounced alterations in the levels of sex hormones occur at later stages of experimental pain syndrome development. The results highlight the temporal characteristics of hormonal mechanisms underlying the implementation of adaptive and compensatory processes under conditions of prolonged pain.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"585-588"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GRO‑α Promotes the Proliferation and Migration of Triple-Negative Breast Cancer Cells through AKT-mTOR Signaling Pathway. GRO‑α通过AKT-mTOR信号通路促进三阴性乳腺癌细胞的增殖和迁移
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06690-1
Shengyang Sun, Lichun Liang, Bing Han, Ziteng Cai, Weiqun Wang, Yikun Qu
{"title":"GRO‑α Promotes the Proliferation and Migration of Triple-Negative Breast Cancer Cells through AKT-mTOR Signaling Pathway.","authors":"Shengyang Sun, Lichun Liang, Bing Han, Ziteng Cai, Weiqun Wang, Yikun Qu","doi":"10.1007/s10517-026-06690-1","DOIUrl":"10.1007/s10517-026-06690-1","url":null,"abstract":"<p><p>Growth-regulated oncogene‑α (GRO‑α) has been widely reported in tumorigenesis. However, the specific contribution of GRO‑α to the malignant behaviors of triple-negative breast cancer (TNBC) remains unclear. Bioinformatics analyses were conducted using the UALCAN and TIMER databases. The underlying mechanism of action of GRO‑α on the progression of TNBC MDA-MB-231 cells was investigated using CCK‑8, EdU, transwell and Western blotting assays. TNBC tissues exhibited elevated expression of GRO‑α, and its high expression was positively correlated with tumor immune cytokines and immune cell recruitment. The growth and migration of TNBC MDA-MB-231 cells were significantly enhanced following treatment with recombinant GRO‑α. Consistently, the protein levels of AKT, p‑mTOR, and mTOR in MDA-MB-231 cells were extremely elevated by recombinant GRO‑α. In addition, the malignant behaviors induced by GRO‑α were surprisingly attenuated following treatment with mTOR inhibitor Torin1. GRO‑α may play a role in the malignant progression of TNBC in an AKT-mTOR-dependent manner.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"631-637"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethylmethylhydroxypyridine Succinate Limits Inflammatory-Degenerative Changes in the Hypothalamus and Corrects Disturbances in the Circadian Rhythm of Corticosterone Secretion in Aged Rats. 琥珀酸乙基甲基羟吡啶限制了下丘脑的炎症退行性变化，并纠正了老年大鼠皮质酮分泌昼夜节律的紊乱。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06679-w
Y I Kirova, O L Terekhina
{"title":"Ethylmethylhydroxypyridine Succinate Limits Inflammatory-Degenerative Changes in the Hypothalamus and Corrects Disturbances in the Circadian Rhythm of Corticosterone Secretion in Aged Rats.","authors":"Y I Kirova, O L Terekhina","doi":"10.1007/s10517-026-06679-w","DOIUrl":"10.1007/s10517-026-06679-w","url":null,"abstract":"<p><p>Aging is associated with chronic low-grade inflammation in the hypothalamus, hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, and disruption of circadian rhythms of glucocorticoid secretion. Using the immunoblotting method, we found that a course of ethylmethylhydroxypyridine succinate (100 mg/kg, daily intraperitoneal injections for 14 days) reduced the level of inflammatory cytokines (IL-1β, TNFα) in the hypothalamus of aged (18-month-old) rats and upregulated the expression of anti-inflammatory cytokines (TGF-β1 and IL-10), growth factors (VEGF and BDNF), markers of mitochondriogenesis (PGC-1α, NDUFV2, SDHA, cyt c1, and COX2) and synaptogenesis (SYP), succinate receptor SUCNR1, and insulin receptor INSRβ. These molecular changes were associated with reduced circulating corticosterone levels, as determined by ELISA. Our findings demonstrate the normalizing effect of succinate/SUCNR1 signaling on the circadian activity of the HPA axis during aging.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"577-584"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in the Expression Levels of Hypoxia-Inducible Factor Isoforms and Their Regulating microRNAs in Peripheral Blood Leukocytes after Hypoxic Exposure in Wistar Rats with Different Tolerance to Oxygen Deficiency. 不同缺氧耐受性Wistar大鼠缺氧暴露后外周血白细胞缺氧诱导因子亚型及其调控microrna表达水平的变化
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06682-1
M V Kirillova, D Sh Dzhalilova, O V Makarova
{"title":"Changes in the Expression Levels of Hypoxia-Inducible Factor Isoforms and Their Regulating microRNAs in Peripheral Blood Leukocytes after Hypoxic Exposure in Wistar Rats with Different Tolerance to Oxygen Deficiency.","authors":"M V Kirillova, D Sh Dzhalilova, O V Makarova","doi":"10.1007/s10517-026-06682-1","DOIUrl":"10.1007/s10517-026-06682-1","url":null,"abstract":"<p><p>Following a single, severe hypoxic exposure (7000 m, 1 h), changes in the expression levels of Hif1a, Epas1 (Hif2a), and Hif3a mRNA, as well as miR-210, miR-107, miR-145, and miR-155 microRNAs in peripheral blood leukocytes were assessed in hypoxia-tolerant (HT) and hypoxia-susceptible (HS) male Wistar rats. HT animals exhibited a significant 148% increase in Epas1 expression, and HS animals demonstrated a 142% increase in Hif3a expression. Reduced expression levels of rno-miR-210-3p, rno-miR-145-3p, and rno-miR-155-3p in HT rats and increased expression of rno-miR-107-5p in HS rats were also detected. These differences confirm previous data obtained in in vitro and in vivo experiments and indicate a more pronounced adaptive response to oxygen deficiency in HS animals.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"592-597"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Uterine Fibroids GWAS-Significant Loci rs11031731 THEM7P/WT1 and rs58415480 SYNE1 with the Risk of Obesity. 子宫肌瘤gwas显著位点rs11031731、THEM7P/WT1和rs8415480 SYNE1与肥胖风险的关系
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06689-8
L A Gliantseva, K I Ragulina, T V Markina, V R Rukavitsyn, G A Lazareva, T A Denisyuk, I N Medvedeva, O Yu Bushueva
{"title":"Association of Uterine Fibroids GWAS-Significant Loci rs11031731 THEM7P/WT1 and rs58415480 SYNE1 with the Risk of Obesity.","authors":"L A Gliantseva, K I Ragulina, T V Markina, V R Rukavitsyn, G A Lazareva, T A Denisyuk, I N Medvedeva, O Yu Bushueva","doi":"10.1007/s10517-026-06689-8","DOIUrl":"10.1007/s10517-026-06689-8","url":null,"abstract":"<p><p>Uterine fibroids and obesity are comorbid conditions with similar pathogenetic mechanisms. The aim of this study was to analyze the association of GWAS-significant uterine fibroid loci with the risk of obesity. DNA genotyping of 115 obese and 218 non-obese patients for 17 SNPs was performed by real-time PCR. An association was established between rs58415480 SYNE1 (effect G allele; OR = 0.61; p = 0.019) and rs11031731 THEM7P/WT1 (effect A allele; OR = 0.63; p = 0.04) with a reduced risk of obesity. Bioinformatic analysis showed that the alleles modulate the binding sites of transcription factors that cause inhibition of adipogenesis, regulation of glucose and lipid metabolism, as well as the retinoic acid and Notch signaling pathways, which indicates the pleiotropic role of these loci and their involvement in both the proliferative and metabolic pathways.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"627-630"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infarct-Limiting Efficacy of the μ2‑Opioid Receptor Peptide Agonist Endomorphin‑1 in Metabolic Syndrome and Aging. μ2 -阿片受体肽激动剂内啡肽- 1对代谢综合征和衰老的梗死限制作用。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06681-2
N V Naryzhnaya, A V Mukhomedzyanov, I A Derkachev, B K Kurbatov, M Kilin, A Kan, L N Maslov
{"title":"Infarct-Limiting Efficacy of the μ<sub>2</sub>‑Opioid Receptor Peptide Agonist Endomorphin‑1 in Metabolic Syndrome and Aging.","authors":"N V Naryzhnaya, A V Mukhomedzyanov, I A Derkachev, B K Kurbatov, M Kilin, A Kan, L N Maslov","doi":"10.1007/s10517-026-06681-2","DOIUrl":"10.1007/s10517-026-06681-2","url":null,"abstract":"<p><p>Infarct-limiting efficacy of endomorphin‑1, a peptide agonist of μ<sub>2</sub>‑opioid receptors (μ<sub>2</sub>‑OR), was studied in rats with metabolic syndrome and during aging. Metabolic syndrome was induced by HFHC diet for 84 days. Coronary artery occlusion (45 min) and reperfusion (2 h) were modeled. Endomorphin‑1 produced a pronounced infarct-limiting effect in control 5‑month-old animals; however, this effect was significantly attenuated in aged (18‑month-old) rats and did not appear in 5‑month-old rats with metabolic syndrome. The μ<sub>2</sub>‑OR agonist endomorphin‑1 is a promising compound for cardioprotection, but its efficacy in the treatment of myocardial infarction in elderly patients and in metabolic syndrome requires additional studies.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"589-591"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Streptococcal Pyrogenic Exotoxin Type A (SpeA) on the Formation of Streptococcus pyogenes Biofilm. 链球菌热原外毒素A型（SpeA）对化脓性链球菌生物膜形成的影响。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06686-x
A G Minko, T A Danilova, V G Lunin, M S Gromova, G A Danilina, A A Adzhieva, V G Zhukhovitsky
{"title":"The Effect of Streptococcal Pyrogenic Exotoxin Type A (SpeA) on the Formation of Streptococcus pyogenes Biofilm.","authors":"A G Minko, T A Danilova, V G Lunin, M S Gromova, G A Danilina, A A Adzhieva, V G Zhukhovitsky","doi":"10.1007/s10517-026-06686-x","DOIUrl":"10.1007/s10517-026-06686-x","url":null,"abstract":"<p><p>The effect of recombinant streptococcal (Streptococcus pyogenes) exotoxin type A (rSpeA) on biofilm formation by S. pyogenes was studied using a laboratory strain of serotype M30 and five non-typeable clinical strains of S. pyogenes. The inhibition of bacterial growth was observed during both the initial formation stage and within established biofilms. It was shown that under the action of rSpeA on biofilm formation, the growth of strain M30 was inhibited by 1.6 times and the growth of strains 1, 2, and 3 was inhibited by 2.3, 1.3, and 1.4 times, respectively. For strains 4 and 5, the inhibition was practically absent. Application of SpeA to the formed biofilm of streptococcal strains produced a more pronounced inhibitory effect: 2.5-fold for strain M30, and 5.5-, 3.4-, and 4.2-fold for strains No. 2, 3, and 5, respectively. These findings suggest that SpeA being a superantigen can also destroy streptococcal biofilms promoting the spread of bacteria in the body and leading to generalization of the infectious process.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"614-617"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3-Acetylpyridine Induced Changes in the Cerebellar Purkinje Cells. 3-乙酰吡啶诱导小脑浦肯野细胞的变化。
IF 0.6 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI: 10.1007/s10517-026-06694-x
D N Voronkov, A V Stavrovskaya, K A Kutukova, I A Potapov, A S Romanenko, A K Pavlova, M V Ivanov, S N Illarioshkin
{"title":"3-Acetylpyridine Induced Changes in the Cerebellar Purkinje Cells.","authors":"D N Voronkov, A V Stavrovskaya, K A Kutukova, I A Potapov, A S Romanenko, A K Pavlova, M V Ivanov, S N Illarioshkin","doi":"10.1007/s10517-026-06694-x","DOIUrl":"10.1007/s10517-026-06694-x","url":null,"abstract":"<p><p>Intraperitoneal administration of 3-acetylpyridine (3-AP) to rodents has previously been proposed for modeling cerebellar degeneration. However, morphological descriptions of changes in the cerebellar Purkinje cells (PCs) are fragmentary. In this work, changes in PCs in rats after 3-AP intoxication were characterized using immunomorphological methods and electron microscopy. Administration of 3-AP caused severe motor disturbances associated with damage, loss, and abnormal distribution of PCs containing aldolase C and a marked decrease in the level of cytochrome oxidase in PCs and synaptophysin in the cerebellar glomeruli. At the ultrastructural level, changes in the PCs of the \"dark type\" were observed. These results allow us to consider administration of 3-AP as a model of spinocerebellar ataxia reproducing motor disturbances and morphological changes in the cerebellar cortex.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"655-659"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书