The Effects of Threefold 30-Minute Inhalation Sessions of an Argon-Oxygen Mixture on a Photochemically Induced Ischemic Stroke Model in Rats.

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-01 Epub Date: 2025-07-19 DOI:10.1007/s10517-025-06427-6

M V Sutormin, E A Boeva, D N Silachev, E I Yakupova, V V Antonova, M A Lubomydrov, S N Kalabushev, A V Erchov, O A Grebenchikov, A N Kuzovlev

引用次数: 0

Abstract

Studies on rats have demonstrated that successive threefold 30-min sessions of inhalation of an argon-oxygen mixture (Ar 70%/O₂ 30%) immediately after and on days 2 and 3 after ischemic stroke reduce neurological deficit, the area of vWF⁺ staining in brain sections, and the number of Iba-1⁺ and Cas-3⁺ cells in the lesion focus and NeuN⁺ cells in the penumbra. However, no differences in the lesion volume were detected by MRI. Argon-oxygen inhalations reduced neurological deficits through their influence on reparative processes within the lesion site.

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三次30分钟吸入氩氧混合物对光化学诱导的大鼠缺血性卒中模型的影响。

对大鼠的研究表明，在缺血性卒中后第2天和第3天连续三次吸入氩氧混合物（Ar 70%/O2 30%），每次30分钟，可减少神经功能缺损、脑切片vWF+染色面积、病变灶内Iba-1+和cas3 +细胞数量以及半暗带内NeuN+细胞数量。然而，MRI未检测到病变体积的差异。氩氧吸入通过影响病变部位的修复过程来减少神经功能缺损。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.