Bulletin of Experimental Biology and Medicine最新文献_第7页

The Influence of Tumor Necrosis Factor Alpha on the Permeability of Nasal Epithelial Cell Monolayer. 肿瘤坏死因子α对鼻上皮细胞单层通透性的影响。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06712-y

Yu V Abalenikhina, D I Breslavets, P Yu Mylnikov, S G Builina, A V Shchulkin, E N Yakusheva

引用次数: 0

Sleeve Gastrectomy Effect on Structural and Functional Myocardium Characteristics and Trpc3, Trpc6, Tgfb1, and Atp2a2 Gene Expression in Rats with Post-Infarction Heart Failure. 袖式胃切除术对梗死后心力衰竭大鼠心肌结构和功能特征及Trpc3、Trpc6、Tgfb1和Atp2a2基因表达的影响

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-29 DOI: 10.1007/s10517-026-06698-7

V I Pan, O V Kornyushin, T A Lelyavina, D O Sonin, A S Polozov, Yu V Cheburkin, P A Kapustina, E A Zaytseva, Ya G Toropova, K V Derkach, A O Shpakov, M M Galagudza

引用次数: 0

Effects of Melatonin in Original Rectal Suppositories on the Neurological Status and Mucosa-Associated and Luminal Microbiota of the Distal Colon in Wistar Rats with Experimental Acute Cerebral Ischemia. 原直肠栓剂中褪黑素对实验性急性脑缺血Wistar大鼠神经系统状态及结肠远端粘膜相关和腔内微生物群的影响

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06702-0

Yu S Shishkova, M V Osikov, M S Boyko, A V Shelomentsev, M A Zotova, A A Fedosov

{"title":"Effects of Melatonin in Original Rectal Suppositories on the Neurological Status and Mucosa-Associated and Luminal Microbiota of the Distal Colon in Wistar Rats with Experimental Acute Cerebral Ischemia.","authors":"Yu S Shishkova, M V Osikov, M S Boyko, A V Shelomentsev, M A Zotova, A A Fedosov","doi":"10.1007/s10517-026-06702-0","DOIUrl":"10.1007/s10517-026-06702-0","url":null,"abstract":"We analyzed the effects of melatonin (MT) administered via rectal suppositories on the composition of the mucosa-associated and luminal microbiota of the distal colon and neurological status of Wistar rats under conditions of experimental acute ischemic stroke (EAIS). The animals received original 100-mg rectal suppositories containing 2.5 mg of MT every 24 h for 3 days. Neurological status was assessed using the Garcia scale and the limb placing test, while microbiota composition in the distal colon was determined using real-time PCR. In rats with EAIS, neurological deficit was observed, characterized by a significant decrease in the Garcia and limb placing scores. In parallel, changes in the colon microbiota were observed: appearance of Clostridioides difficile, Fusobacterium nucleatum, Enterobacter spp., and the disappearance of Enterococcus spp. The administration of original MT-containing rectal suppositories led to partial recovery of neurological deficit, as manifested by in an increase in the Garcia score and limb placing test performance, which was accompanied by the appearance of Bacteroides thetaiotaomicron and the disappearance of Cl. difficile in the colon microbiota. Correlation analysis demonstrated that the amelioration of the neurological deficit was accompanied by changes in the gut microbiota. The effect of MT in rectal suppositories on neurological status and the gut microbiota is attributed to its neuroprotective and bacteriostatic properties.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"703-706"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Microfluidic Sperm Sorting Affect Embryo Ploidy in Human In Vitro Fertilization? 微流控精子分选对体外受精胚胎倍性有影响吗？

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-28 DOI: 10.1007/s10517-026-06714-w

N P Makarova, A A Seliverstova, I S Kichko, E N Ekimov, A P Sysoeva, M Yu Gavrilov, B V Zingerenko, E A Kalinina

引用次数: 0

Lipopeptides from Bacillus subtilis GM5 Inhibit Biofilm Formation by Staphylococcus epidermidis through Regulation of Gene Expression. 枯草芽孢杆菌GM5脂肽通过调控基因表达抑制表皮葡萄球菌形成生物膜。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06708-8

G F Lutfullina, M T Lutfullin, A M Mardanova

引用次数: 0

CLOCK rs1801260 and MTNR1B rs10830963 Polymorphisms Modulate the Association between Cholesterol Levels and Circadian Rhythms in Arctic Residents. CLOCK rs1801260和MTNR1B rs10830963多态性调节北极居民胆固醇水平与昼夜节律的关系

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06710-0

D G Gubin, S N Kolomeychuk, I M Petrov, A A Markov, Yu A Petrova, K A Voronin, M S Mezhakova, Y V Boldyreva, A U Shigabaeva

引用次数: 0

Protein Kinase C Blockers Do Not Reverse the Cardioprotective Effect of Probiotic Strains in Rats with a Systemic Inflammatory Response. 蛋白激酶C阻滞剂不能逆转益生菌菌株对全身炎症反应大鼠的心脏保护作用。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-30 DOI: 10.1007/s10517-026-06696-9

Yu Yu Borshchev, S M Minasyan, I Yu Burovenko, A D Gordeev, V Yu Borshchev, O V Borshcheva, M M Galagudza

{"title":"Protein Kinase C Blockers Do Not Reverse the Cardioprotective Effect of Probiotic Strains in Rats with a Systemic Inflammatory Response.","authors":"Yu Yu Borshchev, S M Minasyan, I Yu Burovenko, A D Gordeev, V Yu Borshchev, O V Borshcheva, M M Galagudza","doi":"10.1007/s10517-026-06696-9","DOIUrl":"10.1007/s10517-026-06696-9","url":null,"abstract":"The hypothesis that protein kinase C (PKC) participates in the signaling stage of the cardioprotective response to the administration of probiotics was tested in experiments on male Wistar rats using a model of systemic inflammatory response syndrome (SIRS), which includes obesity and chemically induced colitis. To provide probiotic cardioprotective effects, Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12) were administered orally. PKC inhibitor chelerythrine at a dose of 0.5 mg/kg was administered intraperitoneally 20 min before the start of isolated Langendorff heart perfusion. Global ischemia (30 min) and reperfusion (90 min) were simulated, after which the size of the necrosis zone was histochemically determined. In the SIRS group, we observed a significant increase in leukocyte count and the size of the necrosis zone (by 39%; p < 0.05) in comparison with the control. In groups with probiotic correction and PKC + probiotic, the size of the necrosis zone was significantly lower than in the SIRS group. Administration of chelerythrine did not abolish the cardioprotective effect of probiotics. In the SIRS model, probiotic-induced cardioprotection is mediated by mechanisms that prevent ischemic/reperfusion damage that differ from the PKC pathway.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"666-670"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of Cortical Associative Areas in Acquisition and Retrieval of Delayed and Traced Conditioned Fear in Mice. 小鼠延迟性和追溯性条理性恐惧习得和检索的皮层关联区参与。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-28 DOI: 10.1007/s10517-026-06695-w

K A Toropova, O I Ivashkina, O S Rogozhnikova, K V Anokhin

{"title":"Involvement of Cortical Associative Areas in Acquisition and Retrieval of Delayed and Traced Conditioned Fear in Mice.","authors":"K A Toropova, O I Ivashkina, O S Rogozhnikova, K V Anokhin","doi":"10.1007/s10517-026-06695-w","DOIUrl":"10.1007/s10517-026-06695-w","url":null,"abstract":"Associative learning is a universal mechanism for acquiring new experience; it can be modeled in animals using fear conditioning (FC). Based on the temporal relationship between the conditioned and unconditioned stimuli, two paradigms of FC are distinguished: delay FC (dFC; where the unconditioned stimulus is presented concurrently with the conditioned one) and the more complex trace FC (tFC; characterized by a gap between the conditioned and unconditioned stimuli). In this study, we compared the activity of associative neocortical areas during the formation and retrieval of memory in these paradigms. Animals successfully acquired both forms of FC; during tFC training, c-Fos expression was observed in the parietal associative cortex. However, neither the parietal associative cortex nor the retrosplenial cortex was activated during memory retrieval in tFC. In contrast, both areas were activated during memory retrieval in dFC. These results provide the first evidence of the differential involvement of parietal associative cortex in the formation and retrieval of different forms of associative memory.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"661-665"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin Amplitude, but Not Phase, Is Associated with Sleep Efficiency in the Arctic. 褪黑素的振幅与北极地区的睡眠效率有关，而不是阶段。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06711-z

D G Gubin, S N Kolomeychuk, I M Petrov, A A Markov, Yu A Petrova, K A Voronin, M S Mezhakova, Y V Boldyreva, A U Shigabaeva

引用次数: 0

Spastic Hypertonia Following Middle Cerebral Artery Occlusion in Rats: Assessment of Behavioral, Electrophysiological, and Morphological Parameters in Dynamics. 大鼠大脑中动脉闭塞后痉挛性高张力：动态行为、电生理和形态学参数的评估。

IF 0.7 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-29 DOI: 10.1007/s10517-026-06700-2

Tian-Yi Sun, Ling-Hui Ma, Liang-Xiao Ma, Qin-Yong Zhang, Xu Qian, Jing-Yun Xiu, Xiu-Yan Wang

{"title":"Spastic Hypertonia Following Middle Cerebral Artery Occlusion in Rats: Assessment of Behavioral, Electrophysiological, and Morphological Parameters in Dynamics.","authors":"Tian-Yi Sun, Ling-Hui Ma, Liang-Xiao Ma, Qin-Yong Zhang, Xu Qian, Jing-Yun Xiu, Xiu-Yan Wang","doi":"10.1007/s10517-026-06700-2","DOIUrl":"10.1007/s10517-026-06700-2","url":null,"abstract":"Gradual changes in muscle resistance after ischemic stroke offer precious insights into the time-course development of spastic hypertonia, but quantitative data about temporal changes in muscle tension are insufficient, particularly about changes in muscle properties in post-stroke animal models. In male Sprague-Dawley rats, changes in the motor function, muscle tension, and spastic muscle structure over a 20-day period after permanent middle cerebral artery occlusion (MCAO) were examined using behavioral tests, electrophysiological recordings, and muscle fiber staining. Motor function evaluated by gait analysis and rotarod test performance were impaired from day 0 to day 10. Muscle tension assessed by Modified Modified Ashworth Scale (MMAS) dropped immediately after MCAO, began to rise on day 3, peaked on day 10, and then decreased somewhat, yet remained relatively high throughout the 20-day observation period. These alterations in muscle tension were also verified by H-reflex recording. On days 10 and 20 postoperatively, the percentage of type I muscle fibers in MCAO group was higher than in sham-operated animals. Our results verified a progressive increase in muscle tension and motor dysfunction on days 3-10 after cerebral ischemia, while changes in structural properties of spastic muscles also contributed to hypertonia. The findings may contribute to better understanding of the recovery process in spastic hypertonia quantitatively in animal model after stroke, and are useful for developing new therapeutic approaches.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"688-695"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0