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Bulletin of Experimental Biology and Medicine最新文献

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Cardio- and Vasoprotective Effects of Quinacrine in an In Vivo Rat Model of Myocardial Ischemia/Reperfusion Injury 喹哪啶在大鼠心肌缺血/再灌注损伤体内模型中的心肌和血管保护作用
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-08-03 DOI: 10.1007/s10517-024-06154-4
D. L. Sonin, E. I. Pochkaeva, G. V. Papayan, S. M. Minasian, D. V. Mukhametdinova, E. A. Zaytseva, D. A. Mochalov, N. N. Petrishchev, M. M. Galagudza
{"title":"Cardio- and Vasoprotective Effects of Quinacrine in an In Vivo Rat Model of Myocardial Ischemia/Reperfusion Injury","authors":"D. L. Sonin, E. I. Pochkaeva, G. V. Papayan, S. M. Minasian, D. V. Mukhametdinova, E. A. Zaytseva, D. A. Mochalov, N. N. Petrishchev, M. M. Galagudza","doi":"10.1007/s10517-024-06154-4","DOIUrl":"https://doi.org/10.1007/s10517-024-06154-4","url":null,"abstract":"<p>This study aimed to investigate the cardioprotective effect of quinacrine in an <i>in vivo</i> model of myocardial ischemia/reperfusion injury. A 30-min regional myocardial ischemia followed by a 2-h reperfusion was modeled in anesthetized Wistar rats. Starting at the last minute of ischemia and during the first 9 min of reperfusion the rats in the control (<i>n</i>=8) and experimental (<i>n</i>=9) groups were injected with 0.9% NaCl and quinacrine solution (5 mg/kg), respectively. The area at risk and infarct size were evaluated by “double staining” with Evans blue and triphenyltetrazolium chloride. To assess vascular permeability in the area at risk zone, indocyanine green (ICG) and thioflavin S (ThS) were injected intravenously at the 90th and 120th minutes of reperfusion, respectively, to assess the no-reflow zone. The images of ICG and ThS fluorescence in transverse sections of rat hearts were obtained using a FLUM multispectral fluorescence organoscope. HR tended to decrease by 13% after intravenous administration of quinacrine and then recovered within 50 min. Quinacrine reduced the size of the necrotic zone (<i>p</i>=0.01), vascular permeability in the necrosis region, and the no-reflow area (<i>p</i>=0.027); at the same time, the area at risk did not significantly differ between the groups. Intravenous administration of quinacrine at the beginning of reperfusion of the rat myocardium reduces no-reflow phenomenon and infarct size.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141883214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphological Characteristics of Colon Tumors in Mice with Different Tolerance to Hypoxia. 对缺氧耐受性不同的小鼠结肠肿瘤的形态特征
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-04 DOI: 10.47056/1814-3490-2024-1-53-60
D. Dzhalilova, M. V. Silina, N. Zolotova, T. S. Portnova, M. D. Vagabov, I. Tsvetkov, O. Makarova
{"title":"Morphological Characteristics of Colon Tumors in Mice with Different Tolerance to Hypoxia.","authors":"D. Dzhalilova, M. V. Silina, N. Zolotova, T. S. Portnova, M. D. Vagabov, I. Tsvetkov, O. Makarova","doi":"10.47056/1814-3490-2024-1-53-60","DOIUrl":"https://doi.org/10.47056/1814-3490-2024-1-53-60","url":null,"abstract":"In adult male C57BL/6 mice with high (HR) and low (LR) resistance to hypoxia, morphological features of colon tumors and blood parameters were evaluated 70 days after intraperitoneal injection of azoxymethane and subsequent consumption of 3 cycles of dextran sulfate sodium. On macroscopic analysis, tumors were found in the distal colon in 35% (7 of 20 animals) of HR and 31% (4 of 13 animals) of LR animals. Microscopic analysis of the distal colon revealed tumors in 75% (15 of 20 animals) of HR and 69% (9 of 13 animals) of LR mice. The tumors were presented by areas of glandular intraepithelial neoplasia and adenocarcinomas; the incidence and the area of the tumors did not differ in groups of HR and LR mice. The number of neuroendocrine and goblet cells in the distal colon mucosa in the areas of tumors was similar in the compared groups. However, in both HR and LR mice of the experimental groups, the content of goblet cells in tumors was lower and the content of endocrine cells was higher than in the corresponding control groups. In the peripheral blood, the erythrocyte count and hemoglobin content decreased in HR and LR mice of the experimental groups; the relative number of monocytes increased only in HR mice and the absolute number of lymphocytes and monocytes decreased in LR mice. Thus, 70 days after azoxymethane administration and dextran sulfate sodium consumption, the tumors in mice were presented by glandular intraepithelial neoplasia and adenocarcinomas, and their incidence and area did not differ between animals with different tolerance to hypoxia.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between the Colony Phenotype and Amino Acid Sequence of the Variable Vaa Antigen in Clinical Isolates of Mycoplasma hominis. 人型支原体临床分离株的菌落表型与可变 Vaa 抗原氨基酸序列之间的相关性
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-04 DOI: 10.47056/0365-9615-2024-177-1-92-96
M. A. Galyamina, K. V. Sikamov, D. R. Urazaeva, A. S. Avshalumov, M. V. Mikhaylycheva, O. Pobeguts, A. Y. Gorbachev
{"title":"Correlation between the Colony Phenotype and Amino Acid Sequence of the Variable Vaa Antigen in Clinical Isolates of Mycoplasma hominis.","authors":"M. A. Galyamina, K. V. Sikamov, D. R. Urazaeva, A. S. Avshalumov, M. V. Mikhaylycheva, O. Pobeguts, A. Y. Gorbachev","doi":"10.47056/0365-9615-2024-177-1-92-96","DOIUrl":"https://doi.org/10.47056/0365-9615-2024-177-1-92-96","url":null,"abstract":"A new Mycoplasma hominis phenotype forming mini-colonies (MC) on agar and distinct from the phenotype forming typical colonies (TC) not only in size, but also in morphology, growth rate, and resistance to adverse factors, has been previously identified. In this study, the phenotype of colonies was determined and a comparative analysis of the amino acid sequence of the main variable antigen Vaa of the laboratory strain N-34 and seven clinical isolates of M. hominis was performed. It is demonstrated that the amino acid sequence of Vaa in clinical isolates forming TC (similar to the laboratory strain N-34) is entirely analogous to that of laboratory strain. Clinical isolates forming MC carry amino acid substitutions in the variable C-terminal region of Vaa, which can contribute to adhesion to eukaryotic cells and immune evasion. The connection between colony phenotype and amino acid sequence of Vaa is established.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association between Ultradian Rhythms of Body Temperature in Small Mammals and Earth's Crust Stress. 小型哺乳动物体温的超昼夜节律与地壳应力之间的联系
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-04 DOI: 10.47056/0365-9615-2024-177-1-120-125
M. A. Diatroptova, A. V. Myasnikov, M. E. Diatroptov
{"title":"Association between Ultradian Rhythms of Body Temperature in Small Mammals and Earth's Crust Stress.","authors":"M. A. Diatroptova, A. V. Myasnikov, M. E. Diatroptov","doi":"10.47056/0365-9615-2024-177-1-120-125","DOIUrl":"https://doi.org/10.47056/0365-9615-2024-177-1-120-125","url":null,"abstract":"Association was assessed between the data harvested by a long-baseline laser interference deformograph and the dynamics of body temperature (BT) in hamsters deprived of natural daily light-darkness changes. The power spectral data revealed the positive correlation between simultaneous time series of hamster BT and the Earth's crust deformation (ECD). The superposed epoch analysis established an association between abrupt upstrokes of hamster BT and ECD increments. Thus, the direct relationships between BT dynamics (reflecting predominance of sympathetic part of autonomic nervous system) and ECD (according to long-baseline laser interference deformography) were established. The study observed synchronization of the free-running circadian rhythm of hamster BT with the tidal stress in Earth's lithosphere. Further studies are needed to find the physical factor underlying the revealed relationships.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pilot Experiment on Non-Invasive Non-Thermal Disintegration of Human Mucinous Breast Carcinoma Ex Vivo Using Boiling Histotripsy. 利用沸腾组织切削技术对人乳腺黏液癌进行活体非侵入性非热分解的试点实验
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-04 DOI: 10.47056/1814-3490-2024-1-21-25
E. Ponomarchuk, S. Tsysar, D. Chupova, P. A. Pestova, A. Kvashennikova, N. V. Danilova, P. Malkov, A. L. Chernyaev, S. Buravkov, V. A. Khokhlova
{"title":"Pilot Experiment on Non-Invasive Non-Thermal Disintegration of Human Mucinous Breast Carcinoma Ex Vivo Using Boiling Histotripsy.","authors":"E. Ponomarchuk, S. Tsysar, D. Chupova, P. A. Pestova, A. Kvashennikova, N. V. Danilova, P. Malkov, A. L. Chernyaev, S. Buravkov, V. A. Khokhlova","doi":"10.47056/1814-3490-2024-1-21-25","DOIUrl":"https://doi.org/10.47056/1814-3490-2024-1-21-25","url":null,"abstract":"We present the results of a pilot study demonstrating the feasibility of non-invasive non-thermal disintegration of human mucinous carcinoma of the breast ex vivo using sequences of high-intensity focused ultrasound pulses in boiling histotripsy regimen. The target volume was sonicated by focusing ultrasound pulses (n=20) of 1.5 MHz frequency, 10-msec duration and 1-sec pulse repetition period, 517 W acoustic power within the pulse, and 103 MPa shock front amplitude at the focus into each node of a volumetric grid 4×4×1 mm. Sonication was visualized and controlled using B-mode ultrasound imaging, total time of the treatment was 21 min. Histological hematoxylin and eosin and Masson's trichrome staining revealed the absence of tumor elements in the treated region confirming destruction of cancer cells and their nuclei after boiling histotripsy procedure.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental Modeling of Cranial Injury and Defect Reconstruction Using Superconstructive Polymers (PEEK). 使用超结构聚合物（PEEK）进行颅骨损伤和缺损重建的实验建模。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-04 DOI: 10.47056/1814-3490-2024-1-45-52
F. Shakova, G. A. Romanova, S. Khashirova, A. S. Vindizheva, Kh. V. Mashukov, M. V. Gulyaev, Z. B. Semenova
{"title":"Experimental Modeling of Cranial Injury and Defect Reconstruction Using Superconstructive Polymers (PEEK).","authors":"F. Shakova, G. A. Romanova, S. Khashirova, A. S. Vindizheva, Kh. V. Mashukov, M. V. Gulyaev, Z. B. Semenova","doi":"10.47056/1814-3490-2024-1-45-52","DOIUrl":"https://doi.org/10.47056/1814-3490-2024-1-45-52","url":null,"abstract":"Experimental model of resection craniotomy with subsequent reconstruction of the defect with a polymer implant enables comprehensive assessment of functional and ultrastructural changes during replacement of the damaged tissue. Reconstruction of a skull defect was accompanied by transient motor disturbance in the acute period and did not cause functional disorders and neurological deficits in a delayed period. Histological examination of osteal and brain tissue revealed no pathological reactions that could be associated with the response to the chemical components of the implant.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiplatelet and Antithrombotic Properties of Compound L-36, a 6H-1,3,4-Thiadiazine Derivative. 6H-1,3,4-噻二嗪衍生物 L-36 化合物的抗血小板和抗血栓特性
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-02 DOI: 10.47056/0365-9615-2024-177-1-74-79
V. Sirotenko, A. A. Spasov, A. Kucheryavenko, K. A. Gaidukova, A. V. Smirnov, Y. Velikorodnaya
{"title":"Antiplatelet and Antithrombotic Properties of Compound L-36, a 6H-1,3,4-Thiadiazine Derivative.","authors":"V. Sirotenko, A. A. Spasov, A. Kucheryavenko, K. A. Gaidukova, A. V. Smirnov, Y. Velikorodnaya","doi":"10.47056/0365-9615-2024-177-1-74-79","DOIUrl":"https://doi.org/10.47056/0365-9615-2024-177-1-74-79","url":null,"abstract":"Compound L-36, a new derivative of 6H-1,3,4-thiadiazine, was studied in in vitro and in vivo experiments. This compound exhibits high antiplatelet and antithrombogenic activity. In in vitro experiments, compound L-36 by its antiplatelet activity (by IC50) was superior to acetylsalicylic acid by 9.4 times. In in vivo experiments, compound L-36 by its ED50 value was close to the comparison drug. On the model of pulmonary artery thrombosis, compound L-36 ensured better survival of experimental animals than acetylsalicylic acid. Morphological studies showed that compound L-36 effectively attenuated the thrombosis processes in the pulmonary tissue induced by intravenous injection of a thrombogenic mixture (epinephrine and collagen).","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141688618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the Acute Toxicity of Chlorophyllin and Trolox for the Possibility of Studying Their Radioprotective Properties. 评估叶绿素和 Trolox 的急性毒性以研究其辐射防护特性的可能性。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-02 DOI: 10.47056/0365-9615-2024-177-1-53-56
L. Romodin, O. Nikitenko, T. M. Bychkova, Yu. A. Zrilova, E. D. Rodionova, D. A. Bocharov
{"title":"Assessment of the Acute Toxicity of Chlorophyllin and Trolox for the Possibility of Studying Their Radioprotective Properties.","authors":"L. Romodin, O. Nikitenko, T. M. Bychkova, Yu. A. Zrilova, E. D. Rodionova, D. A. Bocharov","doi":"10.47056/0365-9615-2024-177-1-53-56","DOIUrl":"https://doi.org/10.47056/0365-9615-2024-177-1-53-56","url":null,"abstract":"The acute toxicity of chlorophyllin and trolox upon intraperitoneal injection of their solutions was studied in male ICR (CD-1) mice. The LD50 of chlorophyllin was found to be 633±37.2 μg/g body weight, which is lower than the LD50 of established radioprotectors. Trolox is technically non-toxic under the conditions of our study. The results obtained highlight the need for a detailed study of the radioprotective properties of trolox and chlorophyllin.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141687874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Study of the Effectiveness of Ethylmethylhydroxypyridine Succinate in Acute Alcohol Intoxication. 甲基羟基吡啶琥珀酸乙酯对急性酒精中毒的疗效研究。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-02 DOI: 10.47056/0365-9615-2024-177-1-61-67
A. Shchulkin, Y. Abalenikhina, P. Mylnikov
{"title":"The Study of the Effectiveness of Ethylmethylhydroxypyridine Succinate in Acute Alcohol Intoxication.","authors":"A. Shchulkin, Y. Abalenikhina, P. Mylnikov","doi":"10.47056/0365-9615-2024-177-1-61-67","DOIUrl":"https://doi.org/10.47056/0365-9615-2024-177-1-61-67","url":null,"abstract":"The effectiveness of ethylmethylhydroxypyridine succinate (EMHPS) in acute alcohol intoxication was tested in a study on SPF male outbred ICR mice. Ethanol (concentration 40%) was administered to animals once intraperitoneally at a dose of 4 g/kg. Control animals were injected with saline in an equivalent volume. In 15 min after the administration of alcohol, the animals were injected intravenously or intramuscularly with EMHPS at a dose of 50 or 100 mg/kg or with saline via the same route in an equivalent volume. Animal behavior was tested 3 and 24 h later after administration of the substances. After 3 and 24 h, mice in the pathological control groups developed semiptosis, the gait and the turning over reflex were impaired, the strength of the hind limbs decreased and the distance between the hind limbs increased when landing; in the open-field test, the latency of the first movement increased, and the number of rearing postures decreased. Intravenous and intramuscular administration of EMHPS in doses of 50 and 100 mg/kg had a pronounced antitoxic and neuroprotective effect in acute alcohol intoxication: all studied parameters did not differ significantly from the control.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141688675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Maternal Hypoxia and Buspirone during Pregnancy on Cognitive Abilities and a Stress Response in Adult Male Offspring. 孕期母体缺氧和丁螺环酮对成年男性后代认知能力和应激反应的影响
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-02 DOI: 10.47056/0365-9615-2024-177-1-14-18
V. Mikhailenko, I. Butkevich, E. A. Vershinina
{"title":"The Influence of Maternal Hypoxia and Buspirone during Pregnancy on Cognitive Abilities and a Stress Response in Adult Male Offspring.","authors":"V. Mikhailenko, I. Butkevich, E. A. Vershinina","doi":"10.47056/0365-9615-2024-177-1-14-18","DOIUrl":"https://doi.org/10.47056/0365-9615-2024-177-1-14-18","url":null,"abstract":"Spatial learning, memory, and reactivity of the hypothalamic-pituitary-adrenocortical system (HPA axis) were studied in adult male rats, whose mothers during pregnancy were subjected to acute moderate normobaric hypoxia, or repeated injections of buspirone, an agonist of type 1A serotonergic receptors (5HT1A), or their combination. Prenatal treatment with buspirone in rats with prenatal hypoxia impaired learning ability during the first day of 5-day training. A decrease in the effectiveness of long-term memory in comparison with short-term memory was revealed in two groups of rats: prenatal treatment with buspirone in combination with hypoxia and injection of physiological saline without hypoxia. The effectiveness of long-term memory and the level of corticosterone in response to stress did not differ between the groups, which can indicate adaptation of the 5HT1A receptor and the HPA axis to the prenatal buspirone and normobaric hypoxia during ontogeny.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141687839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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