表达神经生长因子的转导嗅鞘细胞移植对实验性阿尔茨海默病大鼠认知功能的影响

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-01 Epub Date: 2025-07-19 DOI:10.1007/s10517-025-06446-3

E K Karsuntseva, A D Voronova, V S Shishkina, V Yu Pokidko, A I Mukhina, A V Chadin, G A Fursa, A V Fedorov, O V Stepanova, V P Chekhonin

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引用次数: 0

摘要

我们评估了以表达神经营养NGF的嗅鞘细胞为基础的基因细胞构建体在雌性Wistar大鼠阿尔茨海默病实验模型中的移植效率。在细胞移植后第3周的被动回避测试中，NGF改善了长期记忆和学习能力。

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The Study of Cognitive Functions of Rats with Experimental Alzheimer's Disease after Transplantation of Transduced Olfactory Ensheathing Cells Expressing Nerve Growth Factor.

We evaluated the efficiency of transplantation of a gene-cell construct based on olfactory ensheathing cells expressing neurotrophic NGF in female Wistar rats with an experimental model of Alzheimer's disease. NGF improved long-term memory and learning ability in the passive avoidance test at week 3 after cell transplantation.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.