X A Butova, A D Khokhlova, G V Kopylova, D V Shchepkin, Yu L Protsenko
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Interatrial Features of Length-Dependent Regulation of Myocardial Force in Paroxysmal Atrial Fibrillation in Rats.
Myocardial stretch is a factor that forms an arrhythmogenic substrate for the progression of atrial fibrillation (AF). The features of force generation remodeling during stretching in the atrial myocardium in AF remain poorly understood. In this study, we analyzed changes in active and passive tension of left and right rat atrial myocardial strips at their diastolic stretching and the slopes of the "length-tension" relationship in acetylcholine-CaCl2-induced paroxysmal AF. In AF, neither magnitudes of the active and passive tension, nor the slope coefficients of the "length-tension" relationship changed significantly relative to the intact control values. However, the differences between the left and right atria in the parameters of length-dependent regulation of passive tension typical of normal atrial myocardium disappeared in paroxysmal AF.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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