Bulletin of Experimental Biology and Medicine最新文献_第6页

Activation of the Complement System and Changes in the Content of Modified Lipoproteins in Antiorthostatic Hypokinesia in Humans and Mice. 补体系统的激活和修饰脂蛋白在人和小鼠抗直立性运动不足中的含量变化。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-25 DOI: 10.1007/s10517-025-06346-6

I B Alchinova, B B Shoibonov, A A Puchkova, M Yu Karganov

引用次数: 0

Involvement of Receptor Apparatus in the Realization of Antinociceptive Activity of Songorine. 感受器参与松果碱抗感觉活性的实现。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-25 DOI: 10.1007/s10517-025-06349-3

Yu V Nesterova, A V Mukhomedzyanov, T N Povetyeva, N I Suslov, P V Kul'pin, O G Afanas'eva, A V Vychuzhanina, O Yu Rybalkina, G N Zyuz'kov, V V Zhdanov, M Yu Minakova

引用次数: 0

The Correlations of Attention with Microstructural Parameters of the Cerebral White Matter in Children and Adolescents. 儿童青少年注意力与脑白质微结构参数的相关性研究。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-27 DOI: 10.1007/s10517-025-06359-1

I N Chadova, O A Butova, G V Bicheva

{"title":"The Correlations of Attention with Microstructural Parameters of the Cerebral White Matter in Children and Adolescents.","authors":"I N Chadova, O A Butova, G V Bicheva","doi":"10.1007/s10517-025-06359-1","DOIUrl":"10.1007/s10517-025-06359-1","url":null,"abstract":"In the context of relevance and social significance of the problem of attention deficit disorder among schoolchildren, we performed 3D-visualization of the brain in children (n=17; age 9-12 years) and adolescents (n=16; age 13-15 years). We found correlations between fractional anisotropy of the white matter fiber tracts (reflecting the quantity of axons and myelinization) assessed by diffusion-weighted magnetic resonance imaging (dMRI) and attention indicators (accuracy and task completion time) in children and adolescents. The improvement of attention between the ages of 9 and 12 years (the second childhood period) was accompanied by an increase in fractional anisotropy in the corpus callosum, while the decrease of attention was associated with the increase in the level of anisotropy in the third segment of superior longitudinal fasciculus (SLFIII). The opposite results were obtained for adolescents. In both groups, the improvement in attention was associated with an increase in fractional anisotropy in the SLFI. A relationship of the obtained results with the data on different terms of maturation of the median (earlier development) and lateral (later development) cerebral structures in ontogeny is discussed.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"478-481"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephroblastoma Overexpressed Protein (NOV/CCN3) Elevated Expression of Inflammation Regulators in a Model of Sepsis-Induced Lung Injury. 肾母细胞瘤过表达蛋白（NOV/CCN3）在脓毒症诱导的肺损伤模型中炎症调节因子的表达升高

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-29 DOI: 10.1007/s10517-025-06355-5

H Zhu, L Liu, M Yang, X Zhu, J Cai, H Huang

{"title":"Nephroblastoma Overexpressed Protein (NOV/CCN3) Elevated Expression of Inflammation Regulators in a Model of Sepsis-Induced Lung Injury.","authors":"H Zhu, L Liu, M Yang, X Zhu, J Cai, H Huang","doi":"10.1007/s10517-025-06355-5","DOIUrl":"10.1007/s10517-025-06355-5","url":null,"abstract":"Nephroblastoma overexpressed protein (NOV, also named CCN3), a member of the CCN (Cy61, CTGF, and NOV) family, is a critical biological marker of the severity of acute respiratory distress syndrome (ARDS). However, no evidence has been presented that CCN3 directly affects acute lung injury (ALI) or ARDS. Intratracheal infusion of LPS is an established method to simulate sepsis and induce ALI. To examine the effect of CCN3 on ALI, we developed in vivo and in vitro models of this disease on mice and type II alveolar epithelial A549 cells, respectively. To further clarify the role of CCN3 in ALI, we constructed a CCN3 overexpression model based on plasmid transfection. The results showed that CCN3 expression was up-regulated in LPS-induced ALI both in vivo and in vitro; this effect was time- and dose-dependent. ELISA revealed that overexpression of CCN3 increased the levels of proinflammatory cytokines IL-1β and TNFα. Flow cytometry and Western blotting showed that overexpression of CCN3 increased the expression of proapoptotic protein Bax and decreased the expression of anti-apoptotic protein Bcl-2, thereby promoting apoptosis of A549 cells. The results suggest that CCN3 antagonists can inhibit progression of inflammation and the development of apoptosis in lung epithelial cells, thereby exerting a possible therapeutic effect in ALI.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"453-459"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychopharmacological and Neuroregenerative Effects of a NF-κB Inhibitor under Conditions of Modeled Ethanol-Induced Encephalopathy. NF-κB抑制剂对乙醇性脑病模型的精神药理学和神经再生作用。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-29 DOI: 10.1007/s10517-025-06368-0

G N Zyuz'kov, V V Zhdanov, L A Miroshnichenko, T Yu Polyakova, E V Simanina, A V Chaykovskyi, V I Agafonov

引用次数: 0

Bioinformatic Analysis of the Transcriptomes of the Spinal Cord Lumbar Enlargement Cells of Mice under Condition of Hind Limb Unloading and Subsequent Rehabilitation. 后肢卸荷及后续康复条件下小鼠脊髓腰椎增大细胞转录组的生物信息学分析

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-25 DOI: 10.1007/s10517-025-06348-4

A N Lisyukov, M I Markelova, I I Gainullin, E E Bekmukhamedova, V V Valiullin, R R Islamov

引用次数: 0

The Effect of Poloxamer Coating on the Toxicity of Carbon Dots in Glioblastoma and Embryonic Kidney Models In Vitro. 波洛沙姆涂层对碳点对胶质母细胞瘤和胚胎肾模型体外毒性的影响。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-26 DOI: 10.1007/s10517-025-06362-6

V V Kudelkina, D U Musaeva, A V Syu, A N Kopylov, A M Kosyreva, A I Alekseeva, O V Makarova, V Yu Timoshenko

{"title":"The Effect of Poloxamer Coating on the Toxicity of Carbon Dots in Glioblastoma and Embryonic Kidney Models In Vitro.","authors":"V V Kudelkina, D U Musaeva, A V Syu, A N Kopylov, A M Kosyreva, A I Alekseeva, O V Makarova, V Yu Timoshenko","doi":"10.1007/s10517-025-06362-6","DOIUrl":"10.1007/s10517-025-06362-6","url":null,"abstract":"Carbon dots (CDs), produced by microwave or hydrothermal synthesis, are low-toxic, carbon-based semiconductor nanoparticles that can be used for imaging of biological objects and antitumor therapy. To impart new functional properties to the CDs for biomedical purposes, they are coated with surfactants, such as poloxamers or pluronics. These are block copolymers of polyoxyethylene and polyoxypropylene. We assessed the cytotoxicity of CDs with and without surfactant coatings in in vitro experiments conducted on mouse glioblastoma M6 and human kidney embryonic HEK293 cell lines. The cell viability evaluated in MTT test and morphological study showed that CDs at concentrations of 0.45 and 0.88 mg/ml without a surfactant coating did not significantly inhibit the growth of HEK293 or M6 cells. However, CDs coated with surfactant (1% poloxamer solution) at a concentration of 0.65 mg/ml significantly reduced the metabolic activity of both cell lines. Thus, the use of a surfactant-coated CDs reduced the metabolic activity of cells. This, combined with their luminescent properties, can be used for both the simultaneous therapy and diagnosis of tumors.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"491-495"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Therapeutic Efficacy of Stromal Cells Isolated from Human Corneal Lenticules for Corneal Repair after Injury in an In Vivo Model. 人角膜透镜体基质细胞对角膜损伤后修复的体内模型疗效评价。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-28 DOI: 10.1007/s10517-025-06375-1

M A Surovtseva, N A Bondarenko, K Yu Krasner, I I Kim, E V Chepeleva, D L Cherepanova, D D Dmitriev, A N Trunov, V V Chernykh, O V Poveshchenko

引用次数: 0

Effect of Immunization with Type 5 Group A Streptococcal Antigens and Liposaccharide (LPS) In Vivo and In Vitro on Splenic and Bone Marrow Multipotent Stromal Cells in Mice. 5型A组链球菌抗原和脂多糖（LPS）体内外免疫对小鼠脾和骨髓多能基质细胞的影响

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-26 DOI: 10.1007/s10517-025-06352-8

Yu F Gorskaya, T A Danilova, A I Tukhvatulin, A Sh Dzharullaeva, E N Semenova, L M Vavilova, E V Nagurskaya, V A Bekhalo, A G Minko, V G Nesterenko

{"title":"Effect of Immunization with Type 5 Group A Streptococcal Antigens and Liposaccharide (LPS) In Vivo and In Vitro on Splenic and Bone Marrow Multipotent Stromal Cells in Mice.","authors":"Yu F Gorskaya, T A Danilova, A I Tukhvatulin, A Sh Dzharullaeva, E N Semenova, L M Vavilova, E V Nagurskaya, V A Bekhalo, A G Minko, V G Nesterenko","doi":"10.1007/s10517-025-06352-8","DOIUrl":"10.1007/s10517-025-06352-8","url":null,"abstract":"The number of multipotent stromal cells (MSC) in the splenic transplants of normal CBA mice in recipients immunized with inactivated type 5 group A streptococcal vaccine decreased by 3.5-1.8 times depending on the age of the recipients in comparison with that in the transplants grafted to the control recipients. Such immunization suppressed MSC transplantability, i.e., their potency to construct and maintain specific microenvironment of initial organs. In 24 h after administration of LPS to normal mice in vivo, the MSC content in the spleen and bone marrow increased by 1.8 and 1.6 times, respectively; in immunized mice, these parameters did not increase after LPS injection. The concentration of TNFα in the culture medium of bone marrow from normal mice increased pronouncedly after treatment with LPS both in vivo and in vitro (from 0 to 16.1±2.0 and to 14.2±0.1 pg/ml, respectively), while in the culture medium of bone marrow cells from of immunized mice, this cytokine was not detected after LPS treatment. Probably, immunization of mice with antigens of type 5 group A streptococci and resulting autoimmunity diminish animal sensitivity to LPS, which is reflected by examined parameters of the stromal tissue.","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"437-441"},"PeriodicalIF":0.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and Molecular Peculiarities of Healing of Uterine Incision when Using Conditioned Media of Bone Marrow Stromal Cells Cultivated under Hypoxic Condition. 缺氧条件下培养骨髓基质细胞对子宫切口愈合的形态学和分子特性。

IF 0.9 4区医学

Bulletin of Experimental Biology and Medicine Pub Date : 2025-02-01 Epub Date: 2025-03-28 DOI: 10.1007/s10517-025-06363-5

N B Tikhonova, A A Temnov, V V Aleksankina, A P Aleksankin, T V Fokina, A N Sklifas, M G Aksenova, A V Elchaninov, A P Milovanov, L M Mikhaleva

引用次数: 0