发布求助
文献互助 智能选刊 最新文献

Bulletin of Experimental Biology and Medicine最新文献

筛选
英文 中文
Comparative Analysis of the Pharmacokinetic Characteristics of 2,6-Diisobornyl-4-Methylphenol and Its Metabolites in Rat Bile under Normal Conditions and in Liver Pathology. 2,6-二异龙脑-4-甲基苯酚及其代谢物在正常和肝脏病理大鼠胆汁中药动学特征的比较分析。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06705-x
G A Frelikh, E A Yanovskaya, A P Lakeev, G A Chernysheva, V I Smolyakova, D V Tsuran, I Yu Chukicheva, A V Kutchin
{"title":"Comparative Analysis of the Pharmacokinetic Characteristics of 2,6-Diisobornyl-4-Methylphenol and Its Metabolites in Rat Bile under Normal Conditions and in Liver Pathology.","authors":"G A Frelikh, E A Yanovskaya, A P Lakeev, G A Chernysheva, V I Smolyakova, D V Tsuran, I Yu Chukicheva, A V Kutchin","doi":"10.1007/s10517-026-06705-x","DOIUrl":"10.1007/s10517-026-06705-x","url":null,"abstract":"<p><p>We studied the pharmacokinetic characteristics of phenolic antioxidant 2,6-diisobornyl-4-methylphenol (IBP) and its metabolites in rat bile following intragastric administration at a dose of 10 mg/kg to rats with toxic liver injury induced by carbon tetrachloride and healthy animals. Bile samples from each animal were collected repeatedly to study the pharmacokinetics of IBP and its metabolites. The content of the analytes was assessed by HPLC-MS/MS. In rats with liver pathology, significant changes in the pharmacokinetic parameters of IBP (a significant decrease in C<sub>max</sub> and AUC<sub>1-12</sub> and an increase in MRT and T<sub>1/2</sub>) were observed along with activation of its metabolism (increased content of metabolites) in comparison with healthy animals. The results confirm the significant influence of liver pathology on the kinetics and metabolism of IBP and underscore the relevance of assessing the biliary excretion of substances at the stage of preclinical research.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"719-722"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dose-Dependent Angiogenic Effects of Intravenous Nicotinamide Riboside in Mice with a Lewis Lung Carcinoma Model. 静脉注射烟酰胺核苷对Lewis肺癌模型小鼠血管生成的剂量依赖性影响。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06704-y
E Y Podyacheva, N Y Semenova, I A Makhnin, V A Simushova, Z E Artyukhina, J V Snezhkova, V D Belogortseva, V A Zinserling, Ya G Toropova
{"title":"Dose-Dependent Angiogenic Effects of Intravenous Nicotinamide Riboside in Mice with a Lewis Lung Carcinoma Model.","authors":"E Y Podyacheva, N Y Semenova, I A Makhnin, V A Simushova, Z E Artyukhina, J V Snezhkova, V D Belogortseva, V A Zinserling, Ya G Toropova","doi":"10.1007/s10517-026-06704-y","DOIUrl":"10.1007/s10517-026-06704-y","url":null,"abstract":"<p><p>We studied the dose-dependent effects of the NAD+ precursor nicotinamide riboside (NR) on tumor angiogenesis in C57BL/6N mice with Lewis lung carcinoma. The pharmacological agent was repeatedly administered intravenously at doses of 300 and 450 mg/kg. Iimmunohistochemical analysis (CD34 class II, clone QBEnd 10) showed that the administration of NR at a dose of 450 mg/kg led to a significant increase in the density of tumor vessels in comparison with animals not treated with NR, while the area of tumor necrosis did not change significantly. These findings align with the RT-qPCR data, specifically the upregulation of Sirt2, the downregulation of Sirt1, Sirt3, and Parp1, and the absence of significant changes in the expression of Nos3 and Vegfa. These findings indicate a pro-angiogenic effect of a high dose of NR, which can be considered in the context of a \"vascular normalization\" strategy to enhance the delivery of chemotherapeutic agents.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"713-718"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis of Novel Derivatives of Pyridoxine and Dicarboxylic Acids as Activators of Transcription Factor Nrf2. 新型吡哆醇和二羧酸衍生物作为转录因子Nrf2激活剂的比较分析。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06703-z
A A Balakina, A D Podgurskaya, V I Amozova, T S Stupina, V A Mumyatova, O S Suvorova, S Ya Gadomsky
{"title":"Comparative Analysis of Novel Derivatives of Pyridoxine and Dicarboxylic Acids as Activators of Transcription Factor Nrf2.","authors":"A A Balakina, A D Podgurskaya, V I Amozova, T S Stupina, V A Mumyatova, O S Suvorova, S Ya Gadomsky","doi":"10.1007/s10517-026-06703-z","DOIUrl":"10.1007/s10517-026-06703-z","url":null,"abstract":"<p><p>We performed a structure-activity relationship analysis of novel maleic acid and pyridoxine derivatives, as well as epigid and morpholine fumarates, as potential inducers of Nrf2 transcription factor. A reduction in the number of hydroxyl groups in the structure of the compounds was shown to decrease their cytoprotective activity. The effectiveness of the compounds as Nrf2 activators depends not only on the presence of maleate or fumarate moieties, but also on the structure of the hydroxyaromatic fragment of the molecule. A derivative of pyridoxine and maleic acid, 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridin-1-ium hydromaleate, is an effective activator of Nrf2 transcription factor and exhibits cytoprotective and antioxidant activity in vitro, which suggests its further evaluation in in vivo models and its potential for novel drug development.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"707-712"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Modification of the Method for Assessing the Intraspecific Antagonistic Activity of Escherichia coli. 一种新的评估大肠杆菌种内拮抗活性方法的改进。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06707-9
A D Sumarokova, V N Afonyushkin, T E Mironova
{"title":"A New Modification of the Method for Assessing the Intraspecific Antagonistic Activity of Escherichia coli.","authors":"A D Sumarokova, V N Afonyushkin, T E Mironova","doi":"10.1007/s10517-026-06707-9","DOIUrl":"10.1007/s10517-026-06707-9","url":null,"abstract":"<p><p>Bacteriocins, such as those produced by Escherichia coli, can be considered a promising alternative to antibiotics. The method of delayed antagonism based on the cross-streak test in our modification consisting in the use of nitrocellulose membranes, provides 80% reproducibility of detection of enrofloxacin-mediated induction of E. coli colicinogeny. Both bacteriostatic and bactericidal effects of colicins from various E. coli strains were demonstrated. No differences were found between autologous and heterologous action of enrofloxacin-induced colicinogeny. E. coli isolates from pig intestines differed in the spectrum of colicin activity and complemented each other, providing cooperative antagonism. Our results highlight the potential of bacteriocins as a promising approach for combating multidrug-resistant bacteria.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"728-732"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The "Double-Hit" Model in Experimental Parkinsonism: Effects of Combined Exposure to Lactacystin and LPS. 实验性帕金森氏症的“双重打击”模型：乳糖酵素和LPS联合暴露的影响。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-28 DOI: 10.1007/s10517-026-06697-8
A V Stavrovskaya, A A Gerasimov, D N Voronkov, A S Romanenko, A S Olshanskiy, A K Pavlova, S N Illarioshkin
{"title":"The \"Double-Hit\" Model in Experimental Parkinsonism: Effects of Combined Exposure to Lactacystin and LPS.","authors":"A V Stavrovskaya, A A Gerasimov, D N Voronkov, A S Romanenko, A S Olshanskiy, A K Pavlova, S N Illarioshkin","doi":"10.1007/s10517-026-06697-8","DOIUrl":"10.1007/s10517-026-06697-8","url":null,"abstract":"<p><p>The present study aimed to investigate a \"double-hit\" model of Parkinson's disease, implying intranigral administration of lactacystin and intraperitoneal injection of LPS. The model group rats exhibited significant deterioration in several parameters of the motor function (p ⩽ 0.04) and emotional impairment (p ⩽ 0.04) compared to the control. Morphological signs of neurodegeneration (p ⩽ 0.001) and microglial activation (p ⩽ 0.02) were observed in the substantia nigra. These findings support the utility of this \"double-hit\" model for elucidating the mechanisms underlying parkinsonism and for preclinical testing of candidate therapeutics.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"671-676"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA Vaccine Encoding the prM-E Polyprotein of the Tick-Borne Encephalitis Virus. 编码蜱传脑炎病毒prM-E多蛋白的DNA疫苗。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-29 DOI: 10.1007/s10517-026-06709-7
E V Tigeeva, V A Yakovlev, M B Borgoyakova, E V Starostina, K P Makarova, D I Vakhitov, E V Protopopova, V A Svyatchenko, V B Loktev, L A Kisakova, D N Kisakov, N B Rudometova, A P Rudometov, L I Karpenko
{"title":"DNA Vaccine Encoding the prM-E Polyprotein of the Tick-Borne Encephalitis Virus.","authors":"E V Tigeeva, V A Yakovlev, M B Borgoyakova, E V Starostina, K P Makarova, D I Vakhitov, E V Protopopova, V A Svyatchenko, V B Loktev, L A Kisakova, D N Kisakov, N B Rudometova, A P Rudometov, L I Karpenko","doi":"10.1007/s10517-026-06709-7","DOIUrl":"10.1007/s10517-026-06709-7","url":null,"abstract":"<p><p>We evaluated immunogenicity of the experimental DNA-vaccine construct pVAX-prM-E encoding the polyprotein prM-E of the tick-borne encephalitis virus (strain Sofjin). It was shown that pVAX-prM-E administered to mice using a needle-free jet injector induced the production of high levels of virus-neutralizing antibodies. The level of humoral response to pVAX-prM-E was comparable to that induced by administration of the commercial Tick-E-Vac vaccine. ELISpot analysis of the T-cell response showed that the obtained construct induces high levels of IFNγ in response to stimulation with a pool of specific E protein peptides. These findings indicate the high protective potential of this experimental DNA vaccine.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"738-742"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of Genes Responsible for Wound Healing in Dermal Fibroblasts under Hypoxia. 缺氧条件下真皮成纤维细胞伤口愈合相关基因的表达。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-29 DOI: 10.1007/s10517-026-06701-1
E V Solovieva, K A Darienko, A A Wainson, A A Panteleyev
{"title":"Expression of Genes Responsible for Wound Healing in Dermal Fibroblasts under Hypoxia.","authors":"E V Solovieva, K A Darienko, A A Wainson, A A Panteleyev","doi":"10.1007/s10517-026-06701-1","DOIUrl":"10.1007/s10517-026-06701-1","url":null,"abstract":"<p><p>During wound healing, which is accompanied by hypoxia at the initial stages, the gene expression profile in fibroblasts shifts to facilitate the synthesis of proteins necessary for tissue restoration. In this study, we describe the influence of various parameters, in particular oxygenation and CO<sub>2</sub> levels in the culture medium, on the implementation of fibroblast wound healing potential, assessed by the expression of HIF-1α-dependent and HIF-1α-independent genes. The presented cell hypoxic conditioning system demonstrates a possible approach to the treatment of chronic non-healing skin wounds based on the use of biocompatible and biodegradable scaffolds seeded with hypoxia-activated fibroblasts.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"696-702"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Evaluation of the Effects of Agar and Biofilm Cultures of Francisella tularensis on the Immunological Reactivity of Experimental Animals. 土拉弗朗西斯菌琼脂和生物膜培养对实验动物免疫反应性影响的比较评价。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06706-w
V I Dubrovina, T P Starovoitova, A B Pyatidesyatnikova, T A Ivanova, A V Mazepa, K V Naumova, A K Syngeeva, S V Balakhonov
{"title":"Comparative Evaluation of the Effects of Agar and Biofilm Cultures of Francisella tularensis on the Immunological Reactivity of Experimental Animals.","authors":"V I Dubrovina, T P Starovoitova, A B Pyatidesyatnikova, T A Ivanova, A V Mazepa, K V Naumova, A K Syngeeva, S V Balakhonov","doi":"10.1007/s10517-026-06706-w","DOIUrl":"10.1007/s10517-026-06706-w","url":null,"abstract":"<p><p>We studied immunogenic properties of biofilm and agar cultures of Francisella tularensis strains. Analysis of the interaction of F. tularensis biofilm cultures with macrophages from experimental animals showed that the bacteria adapt to adverse conditions by forming biofilms, thereby increasing their virulence and subsequently suppressing the functional activity of immune cells. Biofilm formation in 7-day-old cultures of F. tularensis strains was associated with an increase in the virulent potential, which led to a decrease in the mean survival time and the overall survival rate of the experimental animals.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"723-727"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Intravenous and Subcutaneous Administration of Boron Particles on the Physiological Status of Immunodeficient SCID Mice. 静脉和皮下注射硼颗粒对免疫缺陷SCID小鼠生理状态的影响。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06699-6
O I Kichakova, P A Kotelnikova, A I Kasatova, E V Barmina, K O Aiyyzhy, M S Grigoryeva, D S Petrunya, E S Prokhorova, L D Romanenko, A A Fronya, S M Deyev, E L Zavjalov, I N Zavestovskaya
{"title":"Effects of Intravenous and Subcutaneous Administration of Boron Particles on the Physiological Status of Immunodeficient SCID Mice.","authors":"O I Kichakova, P A Kotelnikova, A I Kasatova, E V Barmina, K O Aiyyzhy, M S Grigoryeva, D S Petrunya, E S Prokhorova, L D Romanenko, A A Fronya, S M Deyev, E L Zavjalov, I N Zavestovskaya","doi":"10.1007/s10517-026-06699-6","DOIUrl":"10.1007/s10517-026-06699-6","url":null,"abstract":"<p><p>We studied the effects of a single administration of two types of boron particles coated with silane-PEG and produced either by laser fragmentation of boron-10 micropowder or by laser ablation of a solid target of enriched boron on body weight, the weight and histological structure of organs (kidney, liver, spleen, heart, lungs, and brain) and on blood parameters in immunodeficient SCID mice. The particles were injected subcutaneously and intravenously at doses of 10, 30, and 100 mg/kg. We observed a dose-dependent effect of boron particles on the lung and spleen weights, with larger particles inducing more pronounced changes. Intravenous administration of large particles at doses of 30 and 100 mg/kg was also associated with an increase in erythrocyte count. Histological examination revealed the presence of both large and small particles in the liver 2 weeks after a single intravenous administration at a dose of 100 mg/kg.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"683-687"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of IL-1β Secretion by Macrophages in Monocyte Culture in Colorectal Cancer. 结直肠癌单核细胞培养中巨噬细胞分泌IL-1β的特征
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-27 DOI: 10.1007/s10517-026-06713-x
N K Sadykhov, N K Shakhpazyan, L M Mikhaleva, A L Bedzhanyan, A A Bumbazhay, A K Konyukova, A S Kontorshchikov, K S Maslenkina
{"title":"Features of IL-1β Secretion by Macrophages in Monocyte Culture in Colorectal Cancer.","authors":"N K Sadykhov, N K Shakhpazyan, L M Mikhaleva, A L Bedzhanyan, A A Bumbazhay, A K Konyukova, A S Kontorshchikov, K S Maslenkina","doi":"10.1007/s10517-026-06713-x","DOIUrl":"10.1007/s10517-026-06713-x","url":null,"abstract":"<p><p>The level of IL1β secretion in culture of LPS-stimulated CD14<sup>+</sup> monocytes from patients with colorectal cancer was determined. Significant differences in cytokine levels were found in patients with early (15.39 [8.358-25.52] pg/mL) and late (30.33 [16.74-44.20] pg/mL) stages of the disease (p = 0.0381). We also revealed a drastic stage-dependent increase in the response to the first stimulation: by 1.6 times in stage I and by 9 times in stage IV (p = 0.023).</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"757-760"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书