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Quantitative Changes in MicroRNAs in Blood Serum and Lymph after Photodynamic Therapy in Experimental Breast Cancer.
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06336-8
A V Kabakov, O V Kazakov, A F Poveshchenko, V N Cherkas, V V Kononchuk, T S Kalinina, N R Bodrova
{"title":"Quantitative Changes in MicroRNAs in Blood Serum and Lymph after Photodynamic Therapy in Experimental Breast Cancer.","authors":"A V Kabakov, O V Kazakov, A F Poveshchenko, V N Cherkas, V V Kononchuk, T S Kalinina, N R Bodrova","doi":"10.1007/s10517-025-06336-8","DOIUrl":"10.1007/s10517-025-06336-8","url":null,"abstract":"<p><p>The study examined the quantitative variations in the levels of pro-oncogenic miRNAs (miRNA-21, miRNA-27a, and miRNA-221) and tumor-suppressive miRNA-429 in blood serum and lymph of female Wistar rats with breast cancer after photodynamic therapy and controls (without treatment). The levels of pro-oncogenic miRNA-21 and miRNA-221 in the blood serum and lymph increased in the control group. Photodynamic therapy significantly reduced the levels of these miRNAs, suggesting the effectiveness of the treatment. The levels of pro-oncogenic miRNA-27a in the blood serum and lymph of both groups were multidirectional. The levels of tumor-suppressing miRNA-429 decreased significantly in the control group and remained low after photodynamic therapy. Therefore, miRNA-21 and miRNA-221 in the blood serum and lymph can be used as markers of the effectiveness of photodynamic therapy.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"360-362"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6 Mice.
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06323-z
N A Beregovoy, G K Volcho, M V Starostina
{"title":"Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6 Mice.","authors":"N A Beregovoy, G K Volcho, M V Starostina","doi":"10.1007/s10517-025-06323-z","DOIUrl":"10.1007/s10517-025-06323-z","url":null,"abstract":"<p><p>The rapid formation and high stability of addictive memory are the main causes of frequent relapse of alcohol and drug diseases, which limits the possibility of complete recovery and necessitates the search for ways to disrupt the formation or enhance the extinction of addictive memory. The present work shows that myelopeptide MP5 accelerates the extinction of morphine-induced conditioned place preference in C57BL/6 mice and supports synaptic plasticity in the hippocampus, while MP2 produced no such effects.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"291-294"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Model of Combination Therapy of Lewis Lung Carcinoma using Resection and Cytostatics.
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-14 DOI: 10.1007/s10517-025-06343-9
N N Ermakova, E G Skurikhin, I L Zharkikh, M A Zhukova, V Yu Pan, E S Pan, M Yu Minakova, S G Morozov, A A Kubatiev, A M Dygai
{"title":"A Model of Combination Therapy of Lewis Lung Carcinoma using Resection and Cytostatics.","authors":"N N Ermakova, E G Skurikhin, I L Zharkikh, M A Zhukova, V Yu Pan, E S Pan, M Yu Minakova, S G Morozov, A A Kubatiev, A M Dygai","doi":"10.1007/s10517-025-06343-9","DOIUrl":"10.1007/s10517-025-06343-9","url":null,"abstract":"<p><p>We propose a model of combination treatment of Lewis lung carcinoma (LLC) in C57BL/6 mice that includes tumor resection and chemotherapy. A single injection of 5×106 LLC cells into the right lateral subcostal region caused the growth of the primary tumor and its metastasis to the lung. For reducing metastasis and mortality after resection, the primary tumor should be removed with subcutaneous fat on day 8 after inoculation. Antitumor and antimetastatic effects and reduced mortality were achieved by intraperitoneal injection of carboplatin (63.3 mg/kg) and paclitaxel (13.3 mg/kg); chemotherapy was administered twice. The combination of the two approaches increased the survival: the antitumor and antimetastatic effects were observed in 60% of mice with LLC relative to resection alone or treatment with cytostatics alone. However, chemoresistance was formed in 40% of mice, the values of the tumor growth inhibition index and the metastasis inhibition index decreased. This was accompanied by the appearance of cancer stem cells in the circulation with the potential for the formation of spheroids in vitro. The presented model (combination of tumor resection and chemotherapy) can be used in the development of new approaches to improve treatment efficiency in patients with lung cancer.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"393-398"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of α1-Adrenergic Receptors in the Regulation of Electrical Activity of Right Atrial Myocardiocytes from 21-Day-Old Rats.
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s10517-025-06322-0
N Mansour, A L Zefirov, N I Ziyatdinova, A M Kuptsova, T L Zefirov
{"title":"The Role of α<sub>1</sub>-Adrenergic Receptors in the Regulation of Electrical Activity of Right Atrial Myocardiocytes from 21-Day-Old Rats.","authors":"N Mansour, A L Zefirov, N I Ziyatdinova, A M Kuptsova, T L Zefirov","doi":"10.1007/s10517-025-06322-0","DOIUrl":"10.1007/s10517-025-06322-0","url":null,"abstract":"<p><p>We studied the influence of the α<sub>1</sub>-adrenergic receptor agonist methoxamine on the frequency of spontaneous activity and the parameters of electrical activity of the atrial myocardium from 21-day-old rats with normal sinus (preserved sinus node) or paced rhythm. Stimulation with methoxamine increased the frequency of spontaneous activity. Under the conditions of preserved sinus rhythm, the α<sub>1</sub>-adrenergic agonist decreased the duration of the repolarization phase of the action potential, whereas at paced rhythm, this parameter increased.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"287-290"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in Levels of MiR-21, MiR-27a, MiR-221, and MiR-429 in the Thymus after Photodynamic Therapy and Surgical Treatment of Breast Cancer in Female Wistar Rats. 雌性Wistar大鼠乳腺癌光动力治疗和手术治疗后胸腺中MiR-21、MiR-27a、MiR-221和MiR-429水平的变化
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-07 DOI: 10.1007/s10517-025-06313-1
O V Kazakov, A V Kabakov, A F Poveshchenko, V N Cherkas
{"title":"Changes in Levels of MiR-21, MiR-27a, MiR-221, and MiR-429 in the Thymus after Photodynamic Therapy and Surgical Treatment of Breast Cancer in Female Wistar Rats.","authors":"O V Kazakov, A V Kabakov, A F Poveshchenko, V N Cherkas","doi":"10.1007/s10517-025-06313-1","DOIUrl":"10.1007/s10517-025-06313-1","url":null,"abstract":"<p><p>We studied the expression levels of microRNAs (miR-21, miR-27a, miR-221, and miR-429) in the thymus of female Wistar rats after surgical treatment of breast cancer (BC) and after photodynamic therapy for BC followed by tumor resection. In the group without treatment, the levels of pro-oncogenic miR-21, miR-27a, and miR-221 in the thymus were reduced in comparison with those in the group of intact control. After surgical treatment of BC, the levels of miR-21 and miR-27a in the thymus increased in comparison with those in BC without treatment. Surgical removal of the tumor followed by photodynamic therapy led to an even greater increase in the levels of miR-21 and miR-27a in the thymus in comparison with those in the group of surgical treatment alone. Expression of the tumor-suppressive miR-429 in the thymus significantly exceeds the levels in the BC without treatment and BC+surgery groups.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"233-236"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of Microglia and Astroglia in Unilateral Focal Traumatic Brain Injury in Rats. 单侧局灶性脑损伤大鼠小胶质细胞和星形胶质细胞的激活。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-07 DOI: 10.1007/s10517-025-06306-0
E E Genrikhs, M O Shedenkova, D N Voronkov, N K Isaev, E V Stelmashook
{"title":"Activation of Microglia and Astroglia in Unilateral Focal Traumatic Brain Injury in Rats.","authors":"E E Genrikhs, M O Shedenkova, D N Voronkov, N K Isaev, E V Stelmashook","doi":"10.1007/s10517-025-06306-0","DOIUrl":"https://doi.org/10.1007/s10517-025-06306-0","url":null,"abstract":"<p><p>The number of microglia cells and astrocytes in layer V of the cerebral cortex was estimated on day 7 after damage caused by a unilateral focal traumatic brain injury of the left hemisphere sensorimotor cortex. Quantitative assessment was performed by counting immunocytochemically stained microglia cells (Iba1 marker) and activated astrocytes (GFAP) at different distances from the lesion site. Activation of microglial and astroglial cells was observed not only in the marginal zone of the lesion of the left hemisphere, but also in the intact hemisphere. The data obtained indicate the dissemination of inflammation in focal traumatic brain injury.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 2","pages":"196-201"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in the Levels of Short-Chain Acids and Tryptophan Metabolites in Mouse Intestine during Experimental Colitis. 实验性结肠炎小鼠肠道短链酸和色氨酸代谢物水平的变化。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-07 DOI: 10.1007/s10517-025-06305-1
V A Sorokin, T V Grigoryeva, O V Kupriyanova, S A Rumyantsev, A V Shestopalov
{"title":"Changes in the Levels of Short-Chain Acids and Tryptophan Metabolites in Mouse Intestine during Experimental Colitis.","authors":"V A Sorokin, T V Grigoryeva, O V Kupriyanova, S A Rumyantsev, A V Shestopalov","doi":"10.1007/s10517-025-06305-1","DOIUrl":"https://doi.org/10.1007/s10517-025-06305-1","url":null,"abstract":"<p><p>The optimal balance of the intestinal microbiota is considered to be an essential part of the human body that affects many metabolic processes. However, the exact role of the gut microbiota in metabolism is still not fully understood. To investigate the metabolic role of gut microbiota, the content of short-chain fatty acids and tryptophan metabolites was studied in mice with sodium dextran sulfate-induced colitis. It was found that the production of short-chain fatty acids increased on experimental day 14, but by experimental day 60, they completely disappeared. At the same time, indoles of bacterial origin increased on experimental day 60.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 2","pages":"189-195"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and Behavioral Comparison of Two Mouse Models of Cerebral Palsy. 两种脑瘫小鼠模型的构建及行为学比较。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-06 DOI: 10.1007/s10517-025-06320-2
Y Tang, Y Li, S Lin, W Wei, H Chen
{"title":"Construction and Behavioral Comparison of Two Mouse Models of Cerebral Palsy.","authors":"Y Tang, Y Li, S Lin, W Wei, H Chen","doi":"10.1007/s10517-025-06320-2","DOIUrl":"https://doi.org/10.1007/s10517-025-06320-2","url":null,"abstract":"<p><p>Cerebral palsy (CP) is the most common neuromuscular disorder in children with no effective therapeutic methods. To examine CP, a large variety of methods and animal models was developed, the most popular are the hypoxic-ischemic (HI) injury and/or LPS injection in mice. In the presented work, HI and LPS were applied on the postnatal day 9 to humanized immunodeficiency mouse pups, thereupon 3 behavioral tests were performed in 8 weeks later. Both HI and LPS caused significant behavioral deficits assessed in the Rotarod test. In gait dynamics and open-field tests, HI and LPS caused significant behavioral deficits reported by some parameters, and the effect of HI was more severe. Additionally, HI and LPS produced the different effects on gait dynamics of the fore and hind paws. Thus, both HI and LPS induced the behavioral disorders in mice, but HI was more suitable for the development of humanized immunodeficiency mouse model of CP.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 2","pages":"273-279"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complex of Angiotensin II with Modified Low-Density Lipoproteins: Behavioral and Hemodynamic Effects in Rats. 血管紧张素II与改性低密度脂蛋白复合物：对大鼠行为和血流动力学的影响。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-07 DOI: 10.1007/s10517-025-06307-z
S M Tolpygo, B B Shoibonov, T S Zamolodchikova, A V Kotov
{"title":"Complex of Angiotensin II with Modified Low-Density Lipoproteins: Behavioral and Hemodynamic Effects in Rats.","authors":"S M Tolpygo, B B Shoibonov, T S Zamolodchikova, A V Kotov","doi":"10.1007/s10517-025-06307-z","DOIUrl":"https://doi.org/10.1007/s10517-025-06307-z","url":null,"abstract":"<p><p>Endogenous multiple modified LDL (mLDL) and the renin-angiotensin system play a significant role in the development of atherosclerosis. It has been found that by behavioral and hemodynamic parameters the physiological activity of angiotensin II (Ang II) in combination with mLDL is considerably modified due to weakening of its diuretic effect and the inversion of hypertensive and tachyarrhythmic effects. Atherosclerosis is a long-term pathological process, so a single administration of artificially synthesized Ang I-mLDL complexes can be considered a model of the first contact of the body with pathogenic factors. We believe that angiotensin complexes with mLDL participate in adaptive and compensatory mechanisms at the initial stages of atherosclerosis and later contribute to its progression.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 2","pages":"202-208"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Urinary Urea Concentration on Hemolytic Activity and Cytotoxicity of Uropathogenic Morganella morganii Strain. 尿尿素浓度对尿源摩氏摩根菌溶血活性和细胞毒性的影响。
IF 0.9 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2024-12-01 Epub Date: 2025-01-07 DOI: 10.1007/s10517-025-06312-2
L F Minnullina, P S Misheeva, G I Mukhtarova, A M Mardanova
{"title":"Influence of Urinary Urea Concentration on Hemolytic Activity and Cytotoxicity of Uropathogenic Morganella morganii Strain.","authors":"L F Minnullina, P S Misheeva, G I Mukhtarova, A M Mardanova","doi":"10.1007/s10517-025-06312-2","DOIUrl":"https://doi.org/10.1007/s10517-025-06312-2","url":null,"abstract":"<p><p>We studied the effect of urinary urea concentration on the hemolysin production and cytotoxicity of the uropathogenic Morganella morganii strain MM 190. The highest hemolytic activity of M. morganii cultivated in urine with low urea concentration (23 and 82 mmol/liter) was observed between 3rd and 4th hours of post-inoculation, while in urine with standard urea level (117 mmol/liter), the activity was observed at 5th hour of post-inoculation. Our findings indicate a correlation between this activity and the expression of the hlyA gene. Bacterial culture fluid containing hemolysin caused the death of up to 40% of urothelial cells; cytotoxicity was more pronounced against OKP-GS kidney carcinoma cells compared to T-24 bladder carcinoma cells. Hence, in urine with higher urea concentrations, hemolytic activity of bacteria was observed at later stages of growth, and this culture fluid exhibited higher cytotoxicity.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 2","pages":"227-232"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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