G N Zyuz'kov, V V Zhdanov, L A Miroshnichenko, T Yu Polyakova, E V Simanina, A V Chaykovskyi, V I Agafonov
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引用次数: 0
Abstract
We studied the psychopharmacological effects of a NF-κB inhibitor, a stimulator of the functions of progenitor cells of the nervous tissue, under conditions of modeled ethanol-induced encephalopathy. The pharmacological agent improved indicators of the orientation and exploratory behavior and reproducibility of the conditioned passive avoidance reflex in experimental animals. These effects developed against the background of a significant increase in the content and proliferative activity of neural stem cells in the subventricular zone of the brain and intensification of their specialization. The results indicate the prospects of developing fundamentally new agents with regenerative activity based on NF-κB blockers for the treatment of alcoholic encephalopathy.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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