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Leptin Associates with Circadian Light Hygiene and REV-ERBα in Arctic Residents. 北极居民瘦素与昼夜光卫生和rev - erba相关
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06726-6
D G Gubin, S N Kolomeychuk, M F Borisenkov, I M Petrov, A A Markov, Yu A Petrova, K A Voronin, M S Mezhakova, Y V Boldyreva, A U Shigabaeva
{"title":"Leptin Associates with Circadian Light Hygiene and REV-ERBα in Arctic Residents.","authors":"D G Gubin, S N Kolomeychuk, M F Borisenkov, I M Petrov, A A Markov, Yu A Petrova, K A Voronin, M S Mezhakova, Y V Boldyreva, A U Shigabaeva","doi":"10.1007/s10517-026-06726-6","DOIUrl":"10.1007/s10517-026-06726-6","url":null,"abstract":"<p><p>Leptin regulates metabolism and is modulated by circadian rhythms and light exposure, which is of fundamental importance for Arctic residents living under conditions of extreme photoperiods. This longitudinal study aimed to investigate the association between morning leptin, seasonal circadian light hygiene, and NR1D1 expression in 64 Arctic residents (aged 18‑54 years; 88.7% women) using 7‑day actigraphy, morning leptin and NR1D1 expression. Better circadian light hygiene, measured as normalized blue light exposure amplitude (NA BLE) was associated with lower morning leptin (β = -0.263; p < 0.001), also after adjusting for photoperiod. This association remained significant after controlling for sex, age, and ethnicity (β = -0.171). Later BLE light onset also predicted elevated leptin (β = 0.162; p = 0.031). In non-natives exclusively, reduced NR1D1 expression correlated with higher leptin (β = -0.276; p = 0.026).</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"57-61"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Mesenchymal Stromal Cells Induced In Vitro toward a Neurogenic Direction Temporarily Increase the Expression of NES, NSE, CHAT, and MAP2 Genes without Changing the Basic Immunophenotype. 体外诱导人间充质间质细胞向神经源性方向暂时增加NES、NSE、CHAT和MAP2基因的表达，但基本免疫表型未发生改变。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-28 DOI: 10.1007/s10517-026-06741-7
A G Ionova, N V Goncharova, M P Potapnev, S M Kosmacheva
{"title":"Human Mesenchymal Stromal Cells Induced In Vitro toward a Neurogenic Direction Temporarily Increase the Expression of NES, NSE, CHAT, and MAP2 Genes without Changing the Basic Immunophenotype.","authors":"A G Ionova, N V Goncharova, M P Potapnev, S M Kosmacheva","doi":"10.1007/s10517-026-06741-7","DOIUrl":"10.1007/s10517-026-06741-7","url":null,"abstract":"<p><p>The pattern of genotypic and immunophenotypic changes in mesenchymal stromal cells (MSCs) induced towards neurogenic differentiation in vitro remains poorly studied. Umbilical cord MSCs from healthy women were cultured in α‑MEM supplemented with 10% human AB(IV) serum and antibiotics. Neuroinduction was performed in KnockOut DMEM/F‑12 medium with StemPro Neural Supplement 2%, FGFb (20 ng/mL), and EGF (20 ng/mL). After 48 h, MSCs exhibited significant upregulation of the neuronal marker mRNAs NES, NSE, CHAT, and MAP2 by 4.3, 4.2, 5.3, and 5.3 times, respectively. During further culturing in complete nutrient medium without inducers, the expression of NES, NSE, CHAT, and MAP2 mRNAs in neuroinduced MSCs decreased by 2.5, 1.6, 2.2, and 3.7 times, respectively, after 6 h, and returned to baseline after 24 h. Throughout the neuroinduction phase and subsequent culturing in the absence of inducers, MSCs retained the basic immunophenotype (CD90<sup>+</sup>CD105<sup>+</sup>CD34<sup>-</sup>CD45<sup>-</sup>CD73<sup>+</sup>CD13<sup>+</sup>). Thus, the observed divergence between the basic phenotype and genotype reflects plasticity of MSCs during neurogenic differentiation in vitro.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"155-163"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Assessment of the Efficacy of Liposomal Xymedon and Its Aqueous Solution in Correction of LPO and Antioxidant Protection in the Liver of Rats with Transplanted Neoplasia Treated with Liposomal Antitumor Drugs. 木美敦脂质体及其水溶液对移植瘤大鼠肝脏LPO修复及抗氧化保护作用的比较研究
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-21 DOI: 10.1007/s10517-026-06723-9
V S Shindyaikina, A V Siprov, E V Romanova, I A Gololobova, N V Shmyreva, P I Skopin
{"title":"Comparative Assessment of the Efficacy of Liposomal Xymedon and Its Aqueous Solution in Correction of LPO and Antioxidant Protection in the Liver of Rats with Transplanted Neoplasia Treated with Liposomal Antitumor Drugs.","authors":"V S Shindyaikina, A V Siprov, E V Romanova, I A Gololobova, N V Shmyreva, P I Skopin","doi":"10.1007/s10517-026-06723-9","DOIUrl":"10.1007/s10517-026-06723-9","url":null,"abstract":"<p><p>We studied the effect of liposomal xymedon (50 and 100 mg/kg) on LPO and antioxidant protection parameters in the liver of rats with Walker-256 carcinoma treated with a liposomal combination of doxorubicin (4 mg/kg) and cyclophosphamide (45 mg/kg) (once intravenously on day 11 after tumor cell transplantation). Xymedon (in liposomes and as an aqueous solution) was administered intravenously for 5 days starting from day 11 of the experiment. The parameters of LPO and antioxidant protection were assessed on days 3 and 7 after chemotherapy. Intensification of LPO in the liver was observed on day 3 after the administration of liposomal cytostatics in comparison with the use of their aqueous solutions. The advantage of liposomal xymedon over its aqueous solution lies in the development of a hepatoprotective effect at the minimum tested dose (50 mg/kg), which is manifested by a decrease in the levels of diene conjugates and MDA with a balanced increase in SOD and catalase activities in the liver, as well as the prevention of diarrhea associated with the use of the aqueous xymedon solution at a dose of 100 mg/kg.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"40-46"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidant and Anxiolytic Effects of Comenic Acid In Vivo and Cytoprotective Action In Vitro Against Manganese-Induced Neurotoxicity. 对锰致神经毒性的体内抗氧化、抗焦虑作用及体外细胞保护作用。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-21 DOI: 10.1007/s10517-026-06720-y
S V Kozin, O M Lyasota, E A Kozlova, A D Rubailo, S V Bobrovnik, A A Dorohova, A V Moiseev, A A Kravtsov
{"title":"Antioxidant and Anxiolytic Effects of Comenic Acid In Vivo and Cytoprotective Action In Vitro Against Manganese-Induced Neurotoxicity.","authors":"S V Kozin, O M Lyasota, E A Kozlova, A D Rubailo, S V Bobrovnik, A A Dorohova, A V Moiseev, A A Kravtsov","doi":"10.1007/s10517-026-06720-y","DOIUrl":"10.1007/s10517-026-06720-y","url":null,"abstract":"<p><p>The study evaluated the effects of comenic acid (100 μM) on the intensity of oxidative processes in the midbrain, as well as on behavioral activity and learning in rats exposed to manganese chloride (MnCl<sub>2</sub>) at a dose corresponding to 100 mg Mn. Manganese intoxication over 42 days led to a significant increase in the level of chemiluminescence of midbrain tissue samples, along with decreased motor activity, increased anxiety, and impaired learning. Administration of comenic acid at a dose of 5 mg/kg starting from day 14 of intoxication largely prevented the induction of oxidative processes and maintained the behavioral and learning parameters at the control levels. It was also found that comenic acid (100 μM) prevented death of rat cerebellar neurons in vitro caused by 100 μM MnCl<sub>2</sub>.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"22-26"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Mdivi‑1 on Mitochondrial Fission and Fusion Proteins in Hippocampal Granule Neurons in Kainate-Induced Injury. Mdivi‑1对海钠盐损伤海马颗粒神经元线粒体裂变和融合蛋白的影响
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06734-6
A V Egorova, M S Ryabova, D N Voronkov, A V Stavrovskaya, A K Pavlova, E N Fedorova, V S Sukhorukov
{"title":"Effects of Mdivi‑1 on Mitochondrial Fission and Fusion Proteins in Hippocampal Granule Neurons in Kainate-Induced Injury.","authors":"A V Egorova, M S Ryabova, D N Voronkov, A V Stavrovskaya, A K Pavlova, E N Fedorova, V S Sukhorukov","doi":"10.1007/s10517-026-06734-6","DOIUrl":"10.1007/s10517-026-06734-6","url":null,"abstract":"<p><p>The effects of Mdivi‑1, a potential neuroprotector and inhibitor of the mitochondrial fission protein (Drp1), on mitochondrial dynamics in neurons of the hippocampal granule cell layer were assessed in Wistar rats treated with kainic acid. Mdivi‑1 administration reduced the elevated levels of active Drp1 and increased the mitochondrial fraction size and the levels of the mitochondrial fusion proteins OPA1 and Mfn2 compared to the group receiving kainic acid alone. The increase in Mfn2 was more pronounced, indicating differential regulation of the outer and inner mitochondrial membrane fusion processes and insufficient compensation of the mitochondrial dynamics balance under the influence of Mdivi‑1. These changes in Mfn2 may be associated with the activation of other protective and compensatory mechanisms. At the same time, Mdivi‑1 did not increase the number of preserved neurons in the granular layer of the dentate gyrus.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"102-107"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DNA Damage in Placental and Fetal Cells in Rats with Perinatal Immune Activation. 围产期免疫激活大鼠胎盘和胎儿细胞DNA损伤
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06731-9
A K Zhanataev, E A Anisina, K L Pligina, A S Solomina, A D Durnev
{"title":"DNA Damage in Placental and Fetal Cells in Rats with Perinatal Immune Activation.","authors":"A K Zhanataev, E A Anisina, K L Pligina, A S Solomina, A D Durnev","doi":"10.1007/s10517-026-06731-9","DOIUrl":"10.1007/s10517-026-06731-9","url":null,"abstract":"<p><p>Nuclear and mitochondrial DNA damage in placental and fetal cells of rats was evaluated in a LPS-induced model of perinatal immune activation. Six hours after a single administration of LPS (0.2 mg/kg), an increase in nuclear DNA damage was observed in both placental and fetal cells. The most pronounced changes were detected in the fetal head region. After 24 h, damage to nuclear DNA was detected in placental cells and the trunk of the fetuses. High variability of this parameter was observed between the placental and fetal samples from the same animal and between different animals. No increase in nuclear DNA damage was revealed 3 h after LPS treatment. Mitochondrial DNA damage in the studied cells was detected after a 6-h exposure to LPS.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"83-87"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling Changes in Erythrocyte Volume Depending on the Conductivity of Ion Channels. 红细胞体积随离子通道电导率的变化。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-21 DOI: 10.1007/s10517-026-06719-5
T V Rudenko, A A Pecheritsyn, V P Demkin, L V Smaglii, V V Rudenko, V V Udut
{"title":"Modeling Changes in Erythrocyte Volume Depending on the Conductivity of Ion Channels.","authors":"T V Rudenko, A A Pecheritsyn, V P Demkin, L V Smaglii, V V Rudenko, V V Udut","doi":"10.1007/s10517-026-06719-5","DOIUrl":"10.1007/s10517-026-06719-5","url":null,"abstract":"<p><p>We developed a physicomathematical model for estimating transmembrane potential and cell volume responses to changes in membrane permeability to cations. Numerical simulations demonstrated that the developed model allows high-sensitivity prediction of cell volume changes depending on physiologically acceptable deviations in the permeability of passive channels for Na<sup>+</sup>, Ca<sup>2+</sup>, and K<sup>+</sup> ions.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"17-21"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of SUCNR1 in Cartilage Tissue and Its Association with Succinate Metabolism in the Metabolic Phenotype of Osteoarthritis. 骨关节炎代谢表型中软骨组织中SUCNR1及其与琥珀酸盐代谢的关系分析。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-21 DOI: 10.1007/s10517-026-06717-7
D R Shodiev, V I Zvyagina, A V Shchul'kin, Yu A Marsyanova, M N Ryabova, E S Belskikh
{"title":"Analysis of SUCNR1 in Cartilage Tissue and Its Association with Succinate Metabolism in the Metabolic Phenotype of Osteoarthritis.","authors":"D R Shodiev, V I Zvyagina, A V Shchul'kin, Yu A Marsyanova, M N Ryabova, E S Belskikh","doi":"10.1007/s10517-026-06717-7","DOIUrl":"10.1007/s10517-026-06717-7","url":null,"abstract":"<p><p>Inflammation disrupts the normal metabolism of chondrocytes, shifting it toward catabolism and thereby accelerating cartilage extracellular matrix degradation. Recent data suggest a possible contribution of succinate-dependent signaling, mediated by the succinate receptor 1 (SUCNR1/GPR91), to these processes. While the involvement of the succinate receptor SUCNR1 in cartilage degeneration is documented, its role in the metabolic phenotype of osteoarthritis remains poorly understood. We conducted a comprehensive assessment of the succinate signaling system in the metabolic phenotype of osteoarthritis by analyzing SUCNR1 expression, intracellular succinate levels, and succinate dehydrogenase activity in human chondrocytes and cartilage tissue. Cartilage homogenates obtained from 25 patients (20 women, 5 men) and a chondrocyte culture were used. Immunocytochemical analysis revealed SUCNR1 in chondrocyte membranes, while ELISA demonstrated increased levels of both SUCNR1 and succinate in osteoarthritis cartilage, with no notable variations observed between load-bearing and non-load-bearing zones. Succinate dehydrogenase activity remained unchanged. These findings indicate the presence of SUCNR1 in cartilage tissue cells and establish the signaling role of succinate in the pathogenesis of metabolic-phenotype osteoarthritis.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"4-8"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monochromatic Short-Wave UV Sensitivity of Pathogenic Bacteria. 病原菌对单色短波紫外线的敏感性。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06724-8
O Yu Manzenyuk, T N Mukhina, M A Kotov, V V Firstova, M R Barkova, V V Kuzin, A N Shemyakin, M Yu Yakimov, V N Androsenko, N G Solovyov
{"title":"Monochromatic Short-Wave UV Sensitivity of Pathogenic Bacteria.","authors":"O Yu Manzenyuk, T N Mukhina, M A Kotov, V V Firstova, M R Barkova, V V Kuzin, A N Shemyakin, M Yu Yakimov, V N Androsenko, N G Solovyov","doi":"10.1007/s10517-026-06724-8","DOIUrl":"10.1007/s10517-026-06724-8","url":null,"abstract":"<p><p>The study provides systematic data on the effect of monochromatic UV irradiation across the short-wave range (200‑400 nm) at 17 distinct wavelengths on the viability of pathogenic bacteria. It was found that each irradiated bacterial species exhibits an individual spectral profile of UV sensitivity. Bacterial viability characteristics were obtained, and UV sensitivity curves were constructed for nine pathogenic bacterial species. Of practical significance is the determination of bactericidal radiation doses required for pathogen inactivation. Furthermore, the constructed spectral UV sensitivity curves allow determining a narrow wavelength range and calculating the mutant-preventing irradiation dose for each pathogen. An individual UV sensitivity profile can be obtained for any unknown cultivable pathogen. The approach is recommended for testing of UV sensitivity of bacterial pathogens, because it enables the use of mild irradiation doses to eliminate both vegetative and persisting cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"47-52"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and Characterization of a New Bacteriophage: Host Range Assessment and Prospects of Use in the Identification of Moraxella spp. 一种新型噬菌体的分离与鉴定：宿主范围评估及其在莫拉菌鉴定中的应用前景。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-04-01 Epub Date: 2026-07-28 DOI: 10.1007/s10517-026-06715-9
N V Pimenov, Z S Mohammed, N A Buzmakova, E A Smirnova, E R Zulkarneev
{"title":"Isolation and Characterization of a New Bacteriophage: Host Range Assessment and Prospects of Use in the Identification of Moraxella spp.","authors":"N V Pimenov, Z S Mohammed, N A Buzmakova, E A Smirnova, E R Zulkarneev","doi":"10.1007/s10517-026-06715-9","DOIUrl":"10.1007/s10517-026-06715-9","url":null,"abstract":"<p><p>Bacteria of the genus Moraxella are significant pathogens in both human clinical practice and veterinary medicine. A novel bacteriophage, designated vB_MboM_ZALNahr, was isolated from environmental sources (wastewater from the Moscow Region) and morphologically classified as a myovirus lytically active against Moraxella spp. The phage exhibits a broad spectrum of lytic activity, affecting 76% of the tested Moraxella isolates of various origins. Genome sequencing revealed integrase genes, indicating the temperate nature of the phage and limiting its therapeutic potential. Phylogenetic analysis demonstrated that the isolate is phylogenetically related to Bacillus phages. The obtained data indicate the potential of vB_MboM_ZALNahr as a specific diagnostic agent.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"764-767"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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