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c‑Fos Expression Reveals Activation of the Thalamofugal System in the Categorization Learning Model in Chicks. c - Fos的表达揭示了小鸡分类学习模型中丘脑系统的激活。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06729-3
E A Diffine, M A Puzik, A A Tiunova, K V Anokhin
{"title":"c‑Fos Expression Reveals Activation of the Thalamofugal System in the Categorization Learning Model in Chicks.","authors":"E A Diffine, M A Puzik, A A Tiunova, K V Anokhin","doi":"10.1007/s10517-026-06729-3","DOIUrl":"10.1007/s10517-026-06729-3","url":null,"abstract":"<p><p>The expression of the transcription factor c‑Fos was mapped in the brains of newborn chicks during visual categorization training. It was found that this learning was accompanied by a significant increase in c‑Fos levels in the hippocampus and striatum, as well as in the pallial structures of the thalamofugal visual pathway and in areas integrating visual information. At the same time, no induction of c‑Fos expression was observed in the pallial portion of the tectofugal visual pathway, which is often considered to be involved in categorization learning. The obtained data expand current understanding of the contribution of parallel visual systems in the avian brain to learning processes.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"73-77"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Tissue-Engineered In Vitro Intestinal Wall Model for Assessing the Immunomodulatory Activity of the Human Gut Microbiota. 用于评估人类肠道微生物群免疫调节活性的组织工程离体肠壁模型。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-26 DOI: 10.1007/s10517-026-06740-8
I V Arutyunyan, A G Soboleva, M S Das, A N Senyagin, I V Podoprigora, D V Balchir, S O Melkova, S Y Faddeeva, A V Elchaninov
{"title":"A Tissue-Engineered In Vitro Intestinal Wall Model for Assessing the Immunomodulatory Activity of the Human Gut Microbiota.","authors":"I V Arutyunyan, A G Soboleva, M S Das, A N Senyagin, I V Podoprigora, D V Balchir, S O Melkova, S Y Faddeeva, A V Elchaninov","doi":"10.1007/s10517-026-06740-8","DOIUrl":"10.1007/s10517-026-06740-8","url":null,"abstract":"<p><p>The development of in vitro models for screening the immunological activity of commensal bacteria in the human microbiota is a promising and highly relevant field of tissue engineering and experimental microbiology. This article describes a technology for fabricating a standardized, accessible, and easy-to-implement tissue-engineered in vitro model of the human intestinal wall. This model reproduces the physiologically relevant ratio of absorptive and mucin-producing enterocytes, while ensuring the spatial distribution and interaction of enterocytes and immune cells without the need for xenogeneic or synthetic scaffold materials. Exposure of the tissue-engineered intestinal model to E. coli O55:B5 LPS leads to the development of an inflammatory response, which was verified by changes in the expression level of the IL8 gene, encoding a key proinflammatory cytokine in dysbiosis. The developed tissue-engineered intestinal model can be used to screen for the immunomodulatory activity of commensal bacterial strains with potential organoprotective effects, as demonstrated by the example of the Opitutia bacterium KCR 482 strain.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"148-154"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal Dynamics of Bihormonal Cells in the Developing Human Pancreas. 人类胰腺发育过程中双激素细胞的时空动态。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-23 DOI: 10.1007/s10517-026-06733-7
Y S Krivova, A E Proshchina, A A Malkov, E G Otlyga, S V Saveliev
{"title":"Spatiotemporal Dynamics of Bihormonal Cells in the Developing Human Pancreas.","authors":"Y S Krivova, A E Proshchina, A A Malkov, E G Otlyga, S V Saveliev","doi":"10.1007/s10517-026-06733-7","DOIUrl":"10.1007/s10517-026-06733-7","url":null,"abstract":"<p><p>Studies of bihormonal cell distribution in the developing human pancreas are limited and focused on the first half of pregnancy. Here, we quantified the distribution of bihormonal insulin<sup>+</sup>/glucagon<sup>+</sup> cells in different forms of the structural organization of the endocrine pancreas across gestational weeks 10-40. It was demonstrated that insulin<sup>+</sup>/glucagon<sup>+</sup> cells are most abundant during early gestation (weeks 10-12) and prevail among single cells and small clusters throughout prenatal development, indicating that these cells belong to a population of immature endocrine cells. In the mantle and bipolar pancreatic islets, these immature bihormonal cells were located among α cells and were not detected among monohormonal β cells.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"95-101"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Cell Line-Derived and Patient-Derived Xenograft Technologies in Oncology (Review). 肿瘤细胞系衍生和患者衍生异种移植技术的比较（综述）。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-24 DOI: 10.1007/s10517-026-06735-5
E A Gantsova, I V Arutyunyan, G D Perevyazkina, K B Gordon, T Kh Fatkhudinov
{"title":"Comparison of Cell Line-Derived and Patient-Derived Xenograft Technologies in Oncology (Review).","authors":"E A Gantsova, I V Arutyunyan, G D Perevyazkina, K B Gordon, T Kh Fatkhudinov","doi":"10.1007/s10517-026-06735-5","DOIUrl":"10.1007/s10517-026-06735-5","url":null,"abstract":"<p><p>The review evaluates the potential of preclinical in vivo modeling of human tumors. Two fundamental xenograft technologies, cell line-derived xenograft (CDX) and patient-derived xenograft (PDX), are described and their roles within the established methodological framework of translational biomedicine are characterized. The discussion covers practical aspects of model creation and the role of immunodeficient animals in the evolution of cancer modeling. Original data and the results of other research groups obtained in the study of tumor xenografts are analyzed. A comprehensive assessment of the advantages and limitations of CDX and PDX tumor models suggests that they play complementary, rather than competing, roles in modern preclinical oncology.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"108-115"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Myc in the Realization of the Growth Potential of Different Types of Neural Progenitor Cells and the Secretory Function of Neuroglial Cells. Myc在实现不同类型神经祖细胞生长潜能和神经胶质细胞分泌功能中的作用。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06730-w
G N Zyuz'kov, L A Miroshnichenko, T Yu Poljakova, A V Chaikovsky, V I Agafonov, A A Churin, M Yu Minakova
{"title":"Role of Myc in the Realization of the Growth Potential of Different Types of Neural Progenitor Cells and the Secretory Function of Neuroglial Cells.","authors":"G N Zyuz'kov, L A Miroshnichenko, T Yu Poljakova, A V Chaikovsky, V I Agafonov, A A Churin, M Yu Minakova","doi":"10.1007/s10517-026-06730-w","DOIUrl":"10.1007/s10517-026-06730-w","url":null,"abstract":"<p><p>The role of the transcription factor Myc in the functioning of multipotent neural stem cells (NSCs), committed neuronal progenitors (CNPs), and neuroglial elements was studied. It was found that this factor inhibits the proliferative and differentiating activities of NSCs, but does not participate in the realization of the growth potential of neuronal-lineage-committed precursors. In vitro experiments demonstrated the fundamental possibility of stimulating the functions of multipotent NSCs and the production of neurotrophic growth factors by neuroglial cells using the Myc-mediated signaling inhibitor KJ-Pyr‑9. The results indicate the promise of using Myc as a new target for neuroregenerative agents.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"78-82"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid Effects of Finerenone on Pulmonary and Venous Hemodynamics in Rabbits after Its Intravenous Administration in Experiment. 芬烯酮静脉给药后对家兔肺和静脉血流动力学的快速影响。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-21 DOI: 10.1007/s10517-026-06721-x
V I Evlakhov, T P Berezina, A Yu Korochinckiy
{"title":"Rapid Effects of Finerenone on Pulmonary and Venous Hemodynamics in Rabbits after Its Intravenous Administration in Experiment.","authors":"V I Evlakhov, T P Berezina, A Yu Korochinckiy","doi":"10.1007/s10517-026-06721-x","DOIUrl":"10.1007/s10517-026-06721-x","url":null,"abstract":"<p><p>Administration of finerenone during perfusion of isolated rabbit lungs caused a decrease in pulmonary artery pressure, capillary hydrostatic pressure, and pulmonary vascular, precapillary, and postcapillary resistances. These parameters decreased approximately to the same extent as in case of administration of L‑type Ca<sup>2+</sup> channels blocker nifedipine. Under conditions of intact systemic circulation, intravenous injection of finerenone elicited a more pronounced decrease in pulmonary arterial pressure and pulmonary vascular resistance relative to nifedipine treatment. Concurrently, blood flow in the caudal vena cava increased to a greater extent than after nifedipine administration. The increased cranial and caudal vena cava flows after intravenous injection of finerenone were a result of vasodilatation of arterial vessels in the respective regions.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"27-31"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of the Thyroglobulin ChEL Domain in Whole Blood of Patients with Thyroid Pathology. 甲状腺病变患者全血中甲状腺球蛋白ChEL结构域的表达
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06727-5
A V Zubkov, I V Zubkova, O A Svitich, V V Fadeev, L G Butova
{"title":"Expression of the Thyroglobulin ChEL Domain in Whole Blood of Patients with Thyroid Pathology.","authors":"A V Zubkov, I V Zubkova, O A Svitich, V V Fadeev, L G Butova","doi":"10.1007/s10517-026-06727-5","DOIUrl":"10.1007/s10517-026-06727-5","url":null,"abstract":"<p><p>The expression of the thyroglobulin (Tg) cholinesterase-like domain (ChEL domain) was detected in whole blood samples from a patient with Graves' disease and a healthy donor. cDNA templates of the TG ChEL domain were synthesized from mRNA isolated from these samples. Using three of the six primer pairs synthesized to amplify human TG cDNA fragments targeting the ChEL domain, four PCR products were obtained and cloned into the pAL2‑T vector. Using PCR and Sanger sequencing, a 900‑bp TG ChEL domain cDNA fragment with three nucleotide substitutions (c.7408C>T, c.7501T>C, and c.7589G>A) was detected in the healthy donor genome. The 900‑bp cDNA fragment from the patient with Graves' disease harbored a single nucleotide substitution c.8071C>T. The expression of these fragments in eukaryotic cell lines may serve as the basis for the production of recombinant Tg peptides in test systems that allow for the comprehensive diagnosis of various thyroid diseases.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"62-68"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of the Fast Sodium Current in the Myocardium of Fish (Nothobranchius furzeri) during Aging. 衰老过程中鱼心肌快钠电流的降低。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-22 DOI: 10.1007/s10517-026-06732-8
T S Filatova, I H Dzhumaniiazova, A V Shamshura, O B Pustovit, D V Abramochkin
{"title":"Reduction of the Fast Sodium Current in the Myocardium of Fish (Nothobranchius furzeri) during Aging.","authors":"T S Filatova, I H Dzhumaniiazova, A V Shamshura, O B Pustovit, D V Abramochkin","doi":"10.1007/s10517-026-06732-8","DOIUrl":"10.1007/s10517-026-06732-8","url":null,"abstract":"<p><p>Aging is associated with physiological remodeling of the organism, including cardiac tissue, and an increased risk of arrhythmias. We analyzed age-related changes in cardiomyocyte morphology and the fast sodium current (I<sub>Na</sub>), which determines cardiac excitability and conduction velocity, in the ventricular myocardium of the short-lived fish Nothobranchius furzeri. Isolated cardiomyocytes from young (2‑month-old) and aged (4‑month-old) fish were examined using light and fluorescence microscopy and the whole-cell patch-clamp technique. Microscopic analysis revealed no evidence of cell hypertrophy or structural changes in the contractile apparatus in cardiomyocytes from aged fish. However, aging was accompanied by a significant decrease in the amplitude of the fast sodium current I<sub>Na</sub>. The absence of changes in the kinetic parameters of the current may be due to a lower density of sodium channels in the cell membrane during aging.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"88-94"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiota of the Sigmoid Colon Mucus in Complicated Forms of Diverticular Disease. 复杂形式憩室疾病中乙状结肠黏液的微生物群。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-21 DOI: 10.1007/s10517-026-06718-6
D R Yarullina, R R Shakirov, Yu S Pankratova, A M Senina, M I Markelova, D R Khusnutdinova, T V Grigoryeva, O Yu Karpukhin
{"title":"Microbiota of the Sigmoid Colon Mucus in Complicated Forms of Diverticular Disease.","authors":"D R Yarullina, R R Shakirov, Yu S Pankratova, A M Senina, M I Markelova, D R Khusnutdinova, T V Grigoryeva, O Yu Karpukhin","doi":"10.1007/s10517-026-06718-6","DOIUrl":"10.1007/s10517-026-06718-6","url":null,"abstract":"<p><p>To study the specificity of the microbiota and its role in the pathogenesis of diverticular disease of the colon, we examined the mucosal microbiota of 26 diverticula from resected sigmoid colon specimens from 13 patients undergoing surgery for various inflammatory complications of the disease. Using 16S rRNA gene sequencing on the Illumina MiSeq platform, we identified some differences indicating a specific pathological process within the diverticulum. However, it remains unclear whether the microbial community triggers inflammation and the development of complications.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"9-16"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C. 丝裂霉素C致人脐带间充质间质细胞应激性衰老。
IF 0.7 4区 医学
Bulletin of Experimental Biology and Medicine Pub Date : 2026-05-01 Epub Date: 2026-09-28 DOI: 10.1007/s10517-026-06738-2
E I Safonova, Yu A Romanov, E A Tyrina
{"title":"Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C.","authors":"E I Safonova, Yu A Romanov, E A Tyrina","doi":"10.1007/s10517-026-06738-2","DOIUrl":"10.1007/s10517-026-06738-2","url":null,"abstract":"<p><p>Studying stress-induced senescence of umbilical cord-derived mesenchymal stromal cells (UCMSCs) is important for ensuring the safety of their application in regenerative medicine. This study provides a comprehensive analysis of senescence features in UC-MSCs 7 days after treatment with mitomycin C (1.5 μg/mL). Despite the accumulation of DNA double-strand breaks (γH2AX/53BP1 foci) and complete proliferation arrest (the absence of Ki‑67<sup>+</sup> cells and the loss of colony-forming ability) while maintaining viability, the cells did not acquire a classical senescent phenotype. Cell cycle arrest was mediated by activation of the p53/p21/p27 pathway without p16 involvement, and was accompanied by increased expression of SASP factors (IL‑8 and PAI‑1) and decreased levels of COL1A1 and SPARC, while SA-β-gal, oxidative stress, mitochondrial dysfunction, and lysosomal accumulation were absent. These findings indicate a unique response of UC-MSCs, namely, a p53-dependent proliferation arrest without full senescence, which reflects the high resistance of perinatal cells to aging.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":" ","pages":"132-139"},"PeriodicalIF":0.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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