Methylene Blue Protects Spatial Working Memory after Traumatic Brain Injury in Mice by Affecting Mitochondrial Quality Control System.

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-29 DOI:10.1007/s10517-025-06458-z

A P Gureev, P I Babenkova, V V Nesterova, D E Volodina, I S Sadovnikova, K A Starodubtsev, M E Ivanov, D N Silachev, E Yu Plotnikov

引用次数: 0

Abstract

The levels of inflammatory markers increased in both mouse blood plasma and affected brain area 24 days after traumatic brain injury, which was accompanied by impairment of spatial working memory. Methylene blue administered during the first 3 days after injury reduced the levels of some inflammation markers and increased the expression of genes involved in the regulation of mitochondrial biogenesis and mitophagy, i.e. genes responsible for mitochondrial quality control. Additionally, methylene blue partially mitigated the cognitive deficits induced by the injury, suggesting it as a promising compound for maintaining brain function after traumas.

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亚甲基蓝通过影响线粒体质量控制系统保护小鼠创伤性脑损伤后的空间工作记忆。

创伤性脑损伤24 d后，小鼠血浆和脑区炎症标志物水平均升高，并伴有空间工作记忆的损伤。在损伤后的头3天给予亚甲基蓝，降低了一些炎症标志物的水平，增加了参与线粒体生物发生和线粒体自噬调控的基因的表达，即负责线粒体质量控制的基因。此外，亚甲基蓝部分减轻了损伤引起的认知缺陷，这表明它是一种有希望维持创伤后大脑功能的化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.