E V Belyaeva, A N Karacheva, T A Bairova, N V Semenova, A V Belskikh, A Yu Marianian, E A Novikova, O A Nikitina, A Yu Sambyalova, O A Ershova, D P Tiumentceva, L I Kolesnikova
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Phosphatidylethanol 16:0/18:1PEth as a Biomarker of Alcohol Consumption during Pregnancy.
Plasma levels of 16:0/18:1PEth is as a laboratory blood marker of alcohol consumption. In a longitudinal cohort study, the plasma levels of 16:0/18:1PEth were measured in women at different gestational periods and the results were compared with the data from three alternative questionnaires of alcohol consumption during pregnancy. Pregnant women (n = 309) were surveyed using T-ACE, TWEAK, and AUDIT questionnaires followed by measurement of 16:0/18:1PEth by HPLC-MS. According to the survey, 61% of pregnant women had an experience of drinking alcohol before the onset of current pregnancy. Objectively, 60, 51, and 49% of involved women had blood plasma levels of 16:0/18:1PEth exceeding 8 ng/ml in the first, second, and third trimesters. The laboratory-confirmed frequency of alcohol consumption in pregnant women is significantly higher (p < 0.001) than in the survey.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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