A P Lykov, A M Goryachkin, A A Prutov, M N Drovosekov, O V Poveshchenko
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The Effectiveness of Recombinant Human Angiogenin during Skin Burn in CD-1 Mice.
A comparative study was conducted to investigate the effects of recombinant human angiogenin and the conditioned media of human somatic cells (bone marrow mesenchymal stromal cells, EA.Hy926 endothelial cells, and human skin fibroblasts) on burn wound healing and the levels of IL-1β, TNFα, IL-10, VEGF, and NO in blood serum and skin samples from CD-1 mice. The study found that angiogenin, similar to the conditioned media of human somatic cells, accelerated wound healing in burns. The number of cytokines in the blood serum and skin changes when angiogenin and conditioned medium of human somatic cells are applied to the burn wound site. Recombinant human angiogenin demonstrated therapeutic potential comparable to that of conditioned media from human somatic cells in terms of wound healing.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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