3D生物支架诱导牙周内源性再生。

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-05-01 Epub Date: 2025-07-19 DOI:10.1007/s10517-025-06442-7

A A Ivanov, O P Popova, A V Kuznetsova, N N Butorina, T I Danilova, A V Latyshev, O O Yanushevich

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引用次数: 0

摘要

在大鼠外科牙周缺损模型中，研究了I型胶原水凝胶中脱细胞牙基质和脱细胞牙周韧带组合用于牙周再生的潜力。在第60天使用显微计算机断层扫描和组织学和免疫组织化学方法对结果进行评估。生物工程结构诱导牙周韧带区域形成牙水泥和新的纤维组织和骨组织。这种生物工程结构可以被认为是修复牙周组织的一种可能的生物支架。

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Induction of Periodontal Endogenous Regeneration by 3D Bioscaffolds.

The potential of a combination of decellularized tooth matrices and decellularized periodontal ligament in a collagen I hydrogel for periodontal regeneration was studied in a rat model of surgical periodontal defect. The results were evaluated using microcomputed tomography and histological and immunohistochemical methods on day 60. The bioengineered construct induced the formation of dental cement and new fibrous and bone tissues in the area of the periodontal ligament. This bioengineered construct can be considered as a possible bioscaffold for the restoration of the periodontal tissue.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.