基于血管紧张素转换酶2特异性基质的研制及功能分析。

IF 0.6 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-06-01 Epub Date: 2025-08-28 DOI:10.1007/s10517-025-06463-2

N N Kostin, T V Bobik, N Yu Rushkevich, G A Skryabin, E N Kaliberda, V D Knorre, I V Smirnov, A G Gabibov

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引用次数: 0

摘要

本研究开发了一种基于重组人血管紧张素转换酶2 （ACE2）的亲和基质，并对其进行了表征。该基质有效地将假型病毒颗粒与SARS-CoV-2刺突蛋白结合。这些发现突出了为体外血液灌流创造新型亲和力基质的前景，旨在降低高病毒血症和严重COVID-19患者的病毒载量。

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Specific Matrix on the Basis of Angiotensin-Converting Enzyme 2: Development and Functional Analysis.

In this study, an affinity matrix based on recombinant human angiotensin-converting enzyme 2 (ACE2) immobilized on a porous polymeric substrate was developed and characterized. The matrix efficiently binds viral particles pseudotyped with the SARS-CoV-2 spike protein. These findings highlight the prospects for creating novel affinity matrices for extracorporeal hemoperfusion aimed at reducing viral load in patients with high viremia and severe COVID-19.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.